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Jaclyn A Stephens, Peiying Liu, Hanzhang Lu, Stacy J Suskauer
Arterial spin labeling (ASL) has emerged as a technique for assessing mild traumatic brain injury (mTBI), as it can noninvasively evaluate cerebrovascular physiology. To date, there is substantial variability in methodology and findings of ASL studies of mTBI. While both increased and decreased perfusion are reported after mTBI, more consistency is emerging when perfusion is examined with regard to symptomology. We evaluated 15 teenage athletes two and six weeks after sports-related concussion (SRC group) using pseudo-continuous ASL...
January 15, 2018: Journal of Neurotrauma
Kai Liu, Bo Li, Shaowen Qian, Qingjun Jiang, Li Li, Wei Wang, Gaiyun Zhang, Yajuan Sun, Gang Sun
Our purpose was to evaluate mental fatigue associated with mild traumatic brain injury (MTBI) and investigate the underlying neurological mechanisms. We used a 20-min psychomotor vigilance test (PVT) related ASL-fMRI to evaluate mental fatigue in 25 MTBI patients in acute phase, 21 MTBI patients in chronic phase, and 20 healthy subjects. Mental fatigue in patients in acute phase was more severe than in chronic phase patients and healthy controls. The first 5-min-PVT increased CBF of patients in acute phase in "bottom-up" and "top-down" attention areas, and decreased CBF in default mode network (DMN) areas...
September 2016: Brain Imaging and Behavior
Hardik Doshi, Natalie Wiseman, Jun Liu, Wentao Wang, Robert D Welch, Brian J O'Neil, Conor Zuk, Xiao Wang, Valerie Mika, Jerzy P Szaflarski, E Mark Haacke, Zhifeng Kou
Mild traumatic brain injury (mTBI) is a significant public health care burden in the United States. However, we lack a detailed understanding of the pathophysiology following mTBI and its relation to symptoms and recovery. With advanced magnetic resonance imaging (MRI), we can investigate brain perfusion and oxygenation in regions known to be implicated in symptoms, including cortical gray matter and subcortical structures. In this study, we assessed 14 mTBI patients and 18 controls with susceptibility weighted imaging and mapping (SWIM) for blood oxygenation quantification...
2015: PloS One
Yang Wang, John D West, Jessica N Bailey, Daniel R Westfall, Hui Xiao, Todd W Arnold, Patrick A Kersey, Andrew J Saykin, Brenna C McDonald
We evaluated cerebral blood flow (CBF) in chronic pediatric mild traumatic brain injury (mTBI) using arterial spin labeling (ASL) magnetic resonance imaging perfusion. mTBI patients showed lower CBF than controls in bilateral frontotemporal regions, with no between-group cognitive differences. Findings suggest ASL may be useful to assess functional abnormalities in pediatric mTBI.
January 2015: Developmental Neuropsychology
E J Grossman, J H Jensen, J S Babb, Q Chen, A Tabesh, E Fieremans, D Xia, M Inglese, R I Grossman
BACKGROUND AND PURPOSE: Cognitive impairment is frequent among patients with mild traumatic brain injury despite the absence of detectable damage on conventional MR imaging. In this study, the quantitative MR imaging techniques DTI, DKI, and ASL were used to measure changes in the structure and function in the thalamus and WM of patients with MTBI during a short follow-up period, to determine whether these techniques can be used to investigate relationships with cognitive performance and to predict outcome...
May 2013: AJNR. American Journal of Neuroradiology
Yulin Ge, Mayur B Patel, Qun Chen, Elan J Grossman, Ke Zhang, Laura Miles, James S Babb, Joseph Reaume, Robert I Grossman
OBJECTIVE: To assess cerebral blood flow (CBF) changes in patients with mild traumatic brain injury (MTBI) using an arterial spin labelling (ASL) perfusion MRI and to investigate the severity of neuropsychological functional impairment with respect to haemodynamic changes. MATERIALS AND METHODS: Twenty-one patients with MTBI and 20 healthy controls were studied at 3T MR. The median time since the onset of brain injury in patients was 24.6 months. Both patients and controls underwent a traditional consensus battery of neurocognitive tests...
July 2009: Brain Injury: [BI]
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