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https://www.readbyqxmd.com/read/29882487/expression-signature-of-lysosomal-associated-transmembrane-protein-4b-in-hepatitis-c-virus-induced-hepatocellular-carcinoma
#1
Gaurav Roy, Papai Roy, Atanu Bhattacharjee, Mudassar Shahid, Mohammad Misbah, Subash Gupta, Mohammad Husain
INTRODUCTION: Hepatocellular carcinoma is a lethal disease worldwide and therefore the establishment of novel diagnostic biomarkers is imperative. In this study, it was hypothesized that an abnormal expression of the lysosomal-associated protein transmembrane 4 beta ( LAPTM4B) gene is crucial in the pathogenesis of hepatitis C virus-mediated hepatocellular carcinoma; hence we investigated the expression profile of LAPTM4B in hepatitis C virus-induced hepatocellular carcinoma. METHODS: A group of 189 consecutive patients (hepatitis C virus-related hepatocellular carcinoma as tumor cases; n=93, hepatitis C virus-related cirrhotics as disease controls; n=96) opting for living donor liver transplantation as a therapeutic surgical regimen were recruited with informed consent...
May 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29806001/a-ceramide-regulated-element-in-the-late-endosomal-protein-laptm4b-controls-amino-acid-transporter-interaction
#2
Kecheng Zhou, Andrea Dichlberger, Hector Martinez-Seara, Thomas K M Nyholm, Shiqian Li, Young Ah Kim, Ilpo Vattulainen, Elina Ikonen, Tomas Blom
Membrane proteins are functionally regulated by the composition of the surrounding lipid bilayer. The late endosomal compartment is a central site for the generation of ceramide, a bioactive sphingolipid, which regulates responses to cell stress. The molecular interactions between ceramide and late endosomal transmembrane proteins are unknown. Here, we uncover in atomistic detail the ceramide interaction of Lysosome Associated Protein Transmembrane 4B (LAPTM4B), implicated in ceramide-dependent cell death and autophagy, and its functional relevance in lysosomal nutrient signaling...
May 23, 2018: ACS Central Science
https://www.readbyqxmd.com/read/29784669/autophagy-cell-viability-and-chemo-resistance-are-regulated-by-mir-489-in-breast-cancer
#3
Hexin Chen, Mithil Soni, Yogin Patel, Eleni Markoutsa, Chunfa Jie, Shou Liu, Peisheng Xu
It is postulated that the complexity and heterogeneity in cancer may hinder most efforts that target a single pathway. Thus, discovery of novel therapeutic agents targeting multiple pathways, such as microRNAs (miRs), holds promise for future cancer therapy. One such miR, miR-489, is downregulated in majority of breast cancer cells and several drug-resistant breast cancer cell lines, but its role and underlying mechanism for tumor suppression and drug resistance needs further investigation. The current study identifies autophagy as a novel pathway targeted by miR-489 and reports Unc-51 like autophagy activating kinase 1 (ULK1) and lysosomal protein transmembrane 4 beta (LAPTM4B) to be direct targets of miR-489...
May 21, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29770955/laptm4b-gene-copy-number-gain-is-associated-with-inferior-response-to-anthracycline-based-chemotherapy-in-hormone-receptor-negative-breast-carcinomas
#4
Orsolya Rusz, Orsolya Papp, Laura Vízkeleti, Béla Ákos Molnár, Kristóf Csaba Bende, Gábor Lotz, Balázs Ács, Zsuzsanna Kahán, Tamás Székely, Ágnes Báthori, Csilla Szundi, Janina Kulka, Zoltán Szállási, Anna-Mária Tőkés
PURPOSE: To determine the associations between lysosomal-associated transmembrane protein 4b (LAPTM4B) gene copy number and response to different chemotherapy regimens in hormone receptor negative (HR-) primary breast carcinomas. PATIENTS AND METHODS: Two cohorts were analyzed: (1) 69 core biopsies from HR-breast carcinomas treated with neoadjuvant chemotherapy (anthracycline based in 72.5% of patients and non-anthracycline based in 27.5% of patients). (2) Tissue microarray (TMA) of 74 HR-breast carcinomas treated with adjuvant therapy (77...
May 16, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29725479/detection-of-urinary-survivin-using-a-magnetic-particles-based-chemiluminescence-immunoassay-for-the-preliminary-diagnosis-of-bladder-cancer-and-renal-cell-carcinoma-combined-with-laptm4b
#5
Yang Yang, Jianjun Xu, Qingyun Zhang
The aim of the present study was to establish a simple step magnetic particles (MPs) based chemiluminescence enzyme immunoassay (CLEIA) for the detection of urinary survivin, and to investigate the diagnostic value of urinary survivin and lysosome-associated protein transmembrane-4β (LAPTM4B) in bladder cancer (BC) and renal cell carcinoma (RCC). The MPs-based CLEIA was developed on the basis of a double antibodies sandwich immunoreaction and luminol-H2 O2 chemiluminescence system. The parameters of the method were optimized and evaluated...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29420626/integrated-micro-messenger-rna-regulatory-networks-in-essential-thrombocytosis
#6
Lu Zhao, Song Wu, Erya Huang, Dimitri Gnatenko, Wadie F Bahou, Wei Zhu
Essential thrombocytosis (ET) is a chronic myeloproliferative disorder with an unregulated surplus of platelets. Complications of ET include stroke, heart attack, and formation of blood clots. Although platelet-enhancing mutations have been identified in ET cohorts, genetic networks causally implicated in thrombotic risk remain unestablished. In this study, we aim to identify novel ET-related miRNA-mRNA regulatory networks through comparisons of transcriptomes between healthy controls and ET patients. Four network discovery algorithms have been employed, including (a) Pearson correlation network, (b) sparse supervised canonical correlation analysis (sSCCA), (c) sparse partial correlation network analysis (SPACE), and, (d) (sparse) Bayesian network analysis-all through a combined data-driven and knowledge-based analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29387221/association-between-laptm4b-gene-polymorphism-and-susceptibility-to-and-prognosis-of-diffuse-large-b-cell-lymphoma
#7
Huirong Ding, Xiaojing Cheng, Ning Ding, Zhihua Tian, Jun Zhu, Chunlian Zhou, Jing Shen, Yuqin Song
Lysosomal protein transmembrane 4β ( LAPTM4B ) is an oncogene that is overexpressed in a number of various types of human cancer. There are two known alleles of LAPTM4B : LAPTM4B*1 and LAPTM4B*2 . The present study assessed the association between LAPTM4B polymorphisms and the susceptibility to diffuse large B-cell lymphoma (DLBCL) and its prognosis. LAPTM4B genotypes were determined using polymerase chain reaction analysis in 164 DLBCL and 350 healthy control cases. The association between LAPTM4B polymorphisms and the risk of DLBCL was analyzed using unconditional logistic regression...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29378908/the-transcription-factor-ap4-promotes-oncogenic-phenotypes-and-cisplatin-resistance-by-regulating-laptm4b-expression
#8
Lu Wang, Yue Meng, Jian-Jun Xu, Qing-Yun Zhang
Lysosomal-associated protein transmembrane-4 beta (LAPTM4B) is a novel oncogene, whose overexpression is involved in cancer occurrence and progression. However, the mechanism of LAPTM4B transcriptional regulation remains unclear. In this study, the results of transcription factor (TF) profiling plate arrays indicated that AP4 was a potential transcription factor regulating LAPTM4B expression. LAPTM4B was positively correlated with AP4 and they were both associated with poor overall and disease-free survival...
May 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29337428/ap4-positively-regulates-laptm4b-to-promote-hepatocellular-carcinoma-growth-and-metastasis-while-reducing-chemotherapy-sensitivity
#9
Yue Meng, Lu Wang, Jianjun Xu, Qingyun Zhang
Polymorphisms of the lysosomal-associated protein transmembrane-4 beta (LAPTM4B) gene are related to various forms of tumour susceptibility, which led us to hypothesize that some unique transcription factors targeting this polymorphism region may affect the biological function of LAPTM4B in tumour progression. In this study, we found that the transcription factor AP4 directly binds to the polymorphism region of the LAPTM4B gene promoter and induces its transcription. In addition, we demonstrated that AP4 promotes hepatocellular carcinoma (HCC) cell proliferation and metastasis and depresses chemotherapy sensitivity via LAPTM4B by activating the PI3K/AKT signalling pathway and caspase-dependent pathway...
March 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29246322/long-noncoding-rna-hcal-facilitates-the-growth-and-metastasis-of-hepatocellular-carcinoma-by-acting-as-a-cerna-of-laptm4b
#10
Cheng-Rong Xie, Fei Wang, Sheng Zhang, Fu-Qiang Wang, Sen Zheng, Zhao Li, Jie Lv, He-Qiang Qi, Qin-Liang Fang, Xiao-Min Wang, Zhen-Yu Yin
Long noncoding RNAs (lncRNAs) are a new class of regulatory noncoding RNAs. Emerging evidences indicate that lncRNAs play a critical role in the development of hepatocellular carcinoma (HCC). Although several lncRNAs have been annotated, the association of most lncRNAs with HCC is unknown. In this study, we investigated lncRNA alterations in HCC by performing lncRNA microarray analysis. We identified a novel lncRNA called HCC-associated lncRNA (HCAL) that was highly expressed in HCC tissues. HCAL upregulation was clinically associated with poor differentiation, intravascular cancer embolus, and decreased survival of patients with HCC...
December 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29108920/correlation-of-lysosome-associated-protein-transmembrane-4%C3%AE-gene-overexpression-with-the-malignant-phenotypes-of-hepatocellular-carcinoma
#11
Hongying Su, Tao Xu, Xiongfei Huang, Shengbing Zang, Bin Wang, Yang Huang, Jingfeng Liu, Aimin Huang
Hepatocellular carcinoma (HCC) is one of the most common and rapidly fatal malignancies, for which hepatitis B virus (HBV) chronic infection constitutes a major risk factor. The lysosome-associated protein transmembrane-4 β gene (LAPTM4B) is a recently identified gene that was found to be overexpressed in several types of cancer. However, the role of LAPTM4B in HCC tumorigenesis and progression has not been clearly determined. The present study demonstrated that the mRNA as well as the protein levels of LAPTM4B were significantly upregulated in HCC specimens...
December 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28927096/laptm4b-2-allele-is-associated-with-the-development-of-papillary-thyroid-carcinoma-in-chinese-women
#12
Yue Meng, Rouli Zhou, Jianjun Xu, Qingyun Zhang
Lysosome-associated protein transmembrane 4-β (LAPTM4B) contains a polymorphic region that contributes to the increased risk of numerous types of tumor. However, no study has yet demonstrated an association between the expression of the LAPTM4B gene and tumor differentiation, and the reason that LAPTM4B polymorphisms affect the susceptibility of individuals to cancer remains to be elucidated. The present study assessed the possible association between LAPTM4B polymorphism and the risk of papillary thyroid carcinoma (PTC), and attempted to identify the underlying mechanism for variation in patient susceptibility with respect to transcription regulation in the polymorphism region...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28618967/association-of-lysosomal-protein-transmembrane-4-beta-gene-polymorphism-with-pancreatic-carcinoma-susceptibility-in-the-chinese-population
#13
Bing Wang, Shan Wang, Guowei Liang, Jianjun Xu, Rouli Zhou, Qingyun Zhang
Pancreatic carcinoma is an aggressive malignancy with particularly low 5-year survival rate. In order to improve the dismal survival rate, identification of new potential susceptibility risk factors for the prevention and early detection of pancreatic carcinoma is of utmost importance. Lysosomal protein transmembrane 4 beta has two alleles designated as LAPTM4B*1 and LAPTM4B*2. The aim of this study was to investigate the association between lysosomal protein transmembrane 4 beta gene polymorphism and the risk of pancreatic carcinoma in China...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28479384/beclin1-antagonizes-laptm4b-mediated-egfr-overactivation-in-gastric-cancer-cells
#14
Miao Tian, Yu Chen, Dan Tian, Xiaofang Qiao, Zhiming Ma, Jinlong Li
Beclin1 is an essential autophagy regulator and a haploinsufficient tumor-suppressor. Reduced Berclin1 expression has been associated with many types of human malignancies including gastric cancer. However, the mechanism of how Beclin1 represses tumorigenesis of gastric cancer remains elusive. In recent proteomics study, we found that Beclin1 is associated with Lysosome-associated transmembrane protein 4β (LAPTM4B). LAPTM4B plays an important role in promoting the growth and proliferation of tumor cells, it is overexpressed in a variety of solid tumors and serves as a biomarker for tumor therapy...
August 30, 2017: Gene
https://www.readbyqxmd.com/read/28476037/increased-levels-of-laptm4b-vegf-and-survivin-are-correlated-with-tumor-progression-and-poor-prognosis-in-breast-cancer-patients
#15
Sha Li, Lu Wang, Yue Meng, Yanli Chang, Jianjun Xu, Qingyun Zhang
OBJECTIVE: This study explored the relationships among the expression of LAPTM4B, VEGF, and survivin and clinicopathological characteristics and prognosis in breast cancer patients. METHODS: The expression of these three molecules in 110 stage I-III breast cancer patients with clinicopathological and follow-up data was detected via immunohistochemistry. Kaplan-Meier and Cox proportional hazard regression analyses were performed to assess the prognostic significance of these markers in breast cancer...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28474358/e2f1-interactive-with-brca1-pathway-induces-hcc-two-different-small-molecule-metabolism-or-cell-cycle-regulation-via-mitochondrion-or-cd4-t-to-cytosol
#16
Qingchun Chen, Lin Wang, Minghu Jiang, Juxiang Huang, Zhenfu Jiang, Haitao Feng, Zhili Ji
Breast cancer 1 (BRCA1) and E2F transcription factor 1 (E2F1) are related to metabolism and cell cycle regulation. However, the corresponding mechanism is not clear in HCC. High BRCA1 direct pathway was constructed with 11 molecules from E2F1 feedback-interactive network in HCC by GRNInfer based on 39 Pearson mutual positive corelation CC ≥0.25 molecules with E2F1. Integration of GRNInfer with GO, KEGG, BioCarta, GNF_U133A, UNIGENE_EST, Disease, GenMAPP databases by DAVID and MAS 3.0, E2F1 feedback-interactive BRCA1 indirect mitochondrion to cytosol pathway was identified as upstream LAPTM4B activation, feedback UNG, downstream BCAT1-HIST1H2AD-TK1 reflecting protein, and DNA binding with enrichment of small molecule metabolism; The corresponding BRCA1 indirect membrane to cytosol pathway as upstream CCNB2-NUSAP1 activation, feedback TTK-HIST1H2BJ-CENPF, downstream MCM4-TK1 reflecting ATP, and microtubule binding with enrichment of CD4+T-related cell cycle regulation in HCC...
February 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28281029/erratum-to-laptm4b-35-is-a-novel-prognostic-factor-for-glioblastoma
#17
Xiaoshu Dong, Kaoru Tamura, Daisuke Kobayashi, Noboru Ando, Kazutaka Sumita, Taketoshi Maehara
No abstract text is available yet for this article.
April 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28245476/laptm4b-predicts-axillary-lymph-node-metastasis-in-breast-cancer-and-promotes-breast-cancer-cell-aggressiveness-in-vitro
#18
Min Xiao, Shanshan Yang, FanLing Meng, Yu Qin, Yue Yang, Shusheng Jia, XiuMing Cai, Changli Li, Yuanxi Huang, Xiaoming Ning
PURPOSE: Lysosome-associated protein transmembrane-4 beta (LAPTM4B) is associated with the prognosis of several human malignancies. In this study, the role of LAPTM4B in the metastatic potential of breast cancer (BC) and its underlying molecular mechanisms were investigated. METHODS: The relationship between LAPTM4B expression and axillary lymph node metastasis was determined in 291 BC specimens by immunohistochemistry. The expression of LAPTM4B in paired BC cells was overexpressed and inhibited to analyse the role of LAPTM4B in the aggressiveness of BC...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28097442/laptm4b-35-is-a-novel-prognostic-factor-for-glioblastoma
#19
Xiaoshu Dong, Kaoru Tamura, Daisuke Kobayashi, Noboru Ando, Kazutaka Sumita, Taketoshi Maehara
Lysosome-associated protein transmembrane-4 beta (LAPTM4B)-35, a newly identified cancer-associated gene, is overexpressed in a wide variety of malignant tumors. However, studies of its expression and role in glioma have not yet been reported. This study aimed to investigate the expression and the role of LAPTM4B-35 in glioma and to assess its value as a prognostic factor. Seventy-seven glioma cases (Grade II in 18 patients, Grade III in 16 and Grade IV in 43) were immunohistochemically examined for LAPTM4B-35, pAkt, factor VIII and Ki-67 expressions...
April 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27862958/nicotine-induced-protein-expression-profiling-reveals-mutually-altered-proteins-across-four-human-cell-lines
#20
Joao A Paulo, Steven P Gygi
Mass spectrometry-based proteomic strategies can profile the expression level of proteins in response to external stimuli. Nicotine affects diverse cellular pathways, however, the nicotine-induced alterations on the global proteome across human cell lines have not been fully elucidated. We measured perturbations in protein levels resulting from nicotine treatment in four cell lines-HEK, HeLa, PaSC, and SH-SY5Y-in a single experiment using tandem mass tags (TMT10-plex) and high-resolution mass spectrometry. We quantified 8590 proteins across all cell lines...
January 2017: Proteomics
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