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https://www.readbyqxmd.com/read/28618967/association-of-lysosomal-protein-transmembrane-4-beta-gene-polymorphism-with-pancreatic-carcinoma-susceptibility-in-the-chinese-population
#1
Bing Wang, Shan Wang, Guowei Liang, Jianjun Xu, Rouli Zhou, Qingyun Zhang
Pancreatic carcinoma is an aggressive malignancy with particularly low 5-year survival rate. In order to improve the dismal survival rate, identification of new potential susceptibility risk factors for the prevention and early detection of pancreatic carcinoma is of utmost importance. Lysosomal protein transmembrane 4 beta has two alleles designated as LAPTM4B*1 and LAPTM4B*2. The aim of this study was to investigate the association between lysosomal protein transmembrane 4 beta gene polymorphism and the risk of pancreatic carcinoma in China...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28479384/beclin1-antagonizes-laptm4b-mediated-egfr-overactivation-in-gastric-cancer-cells
#2
Miao Tian, Yu Chen, Dan Tian, Xiaofang Qiao, Zhiming Ma, Jinlong Li
Beclin1 is an essential autophagy regulator and a haploinsufficient tumor-suppressor. Reduced Berclin1 expression has been associated with many types of human malignancies including gastric cancer. However, the mechanism of how Beclin1 represses tumorigenesis of gastric cancer remains elusive. In recent proteomics study, we found that Beclin1 is associated with Lysosome-associated transmembrane protein 4β (LAPTM4B). LAPTM4B plays an important role in promoting the growth and proliferation of tumor cells, it is overexpressed in a variety of solid tumors and serves as a biomarker for tumor therapy...
May 4, 2017: Gene
https://www.readbyqxmd.com/read/28476037/increased-levels-of-laptm4b-vegf-and-survivin-are-correlated-with-tumor-progression-and-poor-prognosis-in-breast-cancer-patients
#3
Sha Li, Lu Wang, Yue Meng, Yanli Chang, Jianjun Xu, Qingyun Zhang
OBJECTIVE: This study explored the relationships among the expression of LAPTM4B, VEGF, and survivin and clinicopathological characteristics and prognosis in breast cancer patients. METHODS: The expression of these three molecules in 110 stage I-III breast cancer patients with clinicopathological and follow-up data was detected via immunohistochemistry. Kaplan-Meier and Cox proportional hazard regression analyses were performed to assess the prognostic significance of these markers in breast cancer...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28474358/e2f1-interactive-with-brca1-pathway-induces-hcc-two-different-small-molecule-metabolism-or-cell-cycle-regulation-via-mitochondrion-or-cd4-t-to-cytosol
#4
Qingchun Chen, Lin Wang, Minghu Jiang, Juxiang Huang, Zhenfu Jiang, Haitao Feng, Zhili Ji
Breast cancer 1 (BRCA1) and E2F transcription factor 1 (E2F1) are related to metabolism and cell cycle regulation. However, the corresponding mechanism is not clear in HCC. High BRCA1 direct pathway was constructed with 11 molecules from E2F1 feedback-interactive network in HCC by GRNInfer based on 39 Pearson mutual positive corelation CC ≥0.25 molecules with E2F1. Integration of GRNInfer with GO, KEGG, BioCarta, GNF_U133A, UNIGENE_EST, Disease, GenMAPP databases by DAVID and MAS 3.0, E2F1 feedback-interactive BRCA1 indirect mitochondrion to cytosol pathway was identified as upstream LAPTM4B activation, feedback UNG, downstream BCAT1-HIST1H2AD-TK1 reflecting protein, and DNA binding with enrichment of small molecule metabolism; The corresponding BRCA1 indirect membrane to cytosol pathway as upstream CCNB2-NUSAP1 activation, feedback TTK-HIST1H2BJ-CENPF, downstream MCM4-TK1 reflecting ATP, and microtubule binding with enrichment of CD4+T-related cell cycle regulation in HCC...
May 5, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28281029/erratum-to-laptm4b-35-is-a-novel-prognostic-factor-for-glioblastoma
#5
Xiaoshu Dong, Kaoru Tamura, Daisuke Kobayashi, Noboru Ando, Kazutaka Sumita, Taketoshi Maehara
No abstract text is available yet for this article.
March 9, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28245476/laptm4b-predicts-axillary-lymph-node-metastasis-in-breast-cancer-and-promotes-breast-cancer-cell-aggressiveness-in-vitro
#6
Min Xiao, Shanshan Yang, FanLing Meng, Yu Qin, Yue Yang, Shusheng Jia, XiuMing Cai, Changli Li, Yuanxi Huang, Xiaoming Ning
PURPOSE: Lysosome-associated protein transmembrane-4 beta (LAPTM4B) is associated with the prognosis of several human malignancies. In this study, the role of LAPTM4B in the metastatic potential of breast cancer (BC) and its underlying molecular mechanisms were investigated. METHODS: The relationship between LAPTM4B expression and axillary lymph node metastasis was determined in 291 BC specimens by immunohistochemistry. The expression of LAPTM4B in paired BC cells was overexpressed and inhibited to analyse the role of LAPTM4B in the aggressiveness of BC...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28097442/laptm4b-35-is-a-novel-prognostic-factor-for-glioblastoma
#7
Xiaoshud Dong, Kaoru Tamura, Daisuke Kobayashi, Noboru Ando, Kazutaka Sumita, Taketoshi Maehara
Lysosome-associated protein transmembrane-4 beta (LAPTM4B)-35, a newly identified cancer-associated gene, is overexpressed in a wide variety of malignant tumors. However, studies of its expression and role in glioma have not yet been reported. This study aimed to investigate the expression and the role of LAPTM4B-35 in glioma and to assess its value as a prognostic factor. Seventy-seven glioma cases (Grade II in 18 patients, Grade III in 16 and Grade IV in 43) were immunohistochemically examined for LAPTM4B-35, pAkt, factor VIII and Ki-67 expressions...
April 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27862958/nicotine-induced-protein-expression-profiling-reveals-mutually-altered-proteins-across-four-human-cell-lines
#8
Joao A Paulo, Steven P Gygi
Mass spectrometry-based proteomic strategies can profile the expression level of proteins in response to external stimuli. Nicotine affects diverse cellular pathways, however, the nicotine-induced alterations on the global proteome across human cell lines have not been fully elucidated. We measured perturbations in protein levels resulting from nicotine treatment in four cell lines-HEK, HeLa, PaSC, and SH-SY5Y-in a single experiment using tandem mass tags (TMT10-plex) and high-resolution mass spectrometry. We quantified 8590 proteins across all cell lines...
January 2017: Proteomics
https://www.readbyqxmd.com/read/27711123/language-agnostic-reproducible-data-analysis-using-literate-programming
#9
Boris Vassilev, Riku Louhimo, Elina Ikonen, Sampsa Hautaniemi
A modern biomedical research project can easily contain hundreds of analysis steps and lack of reproducibility of the analyses has been recognized as a severe issue. While thorough documentation enables reproducibility, the number of analysis programs used can be so large that in reality reproducibility cannot be easily achieved. Literate programming is an approach to present computer programs to human readers. The code is rearranged to follow the logic of the program, and to explain that logic in a natural language...
2016: PloS One
https://www.readbyqxmd.com/read/27542271/targeting-a-novel-cancer-driving-protein-laptm4b-35-by-a-small-molecule-ets-to-inhibit-cancer-growth-and-metastasis
#10
Maojin Li, Rouli Zhou, Yi Shan, Li Li, Lin Wang, Gang Liu
Our previous studies demonstrated that LAPTM4B-35 is overexpressed in a variety of solid cancers including hepatocellular carcinoma (HCC), and is an independent factor for prognosis. LAPTM4B-35 overexpression causes carcinogenesis and enhances cancer growth, metastasis and multidrug resistance, and thus may be a candidate for therapeutic targeting. The present study shows ethylglyoxal bisthiosemicarbazon (ETS) has effective anticancer activity through LAPTM4B-35 targeting. Bel-7402 and HepG2 cell lines from human HCC were used as cell models in which LAPTM4B-35 is highly expressed, and a human fetal liver cell line was used as a control...
September 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27486880/overexpressed-laptm4b-35-is-a-risk-factor-for-cancer-recurrence-and-poor-prognosis-in-non-small-cell-lung-cancer
#11
Fanming Kong, Fangfang Gao, Jun Chen, Yiyu Sun, Ying Zhang, Honggen Liu, Xiaojiang Li, PeiYing Yang, Rongxiu Zheng, Geli Liu, Yingjie Jia
BACKGROUND: The expression levels and clinical significances of Lysosomal-associated protein transmembrane-4β-35 (LAPTM4B-35) protein are unknown in the non-small-cell lung cancer (NSCLC). This study aimed to explore the expression and prognostic value of LAPTM4B-35 in NSCLC patients. METHODS: The clinicopathological and survival data of 107 NSCLC patients who received radical surgery from 2007 and 2011 were reviewed. The LAPTM4B-35 expression of the paired tumors and adjacent normal specimens were detected, and the association between LAPTM4B-35 and clinical variables was explored...
August 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27391361/relationship-between-laptm4b-gene-polymorphism-and-prognosis-of-patients-following-tumor-resection-for-colorectal-and-esophageal-cancers
#12
Xiaojing Cheng, Xiuyun Tian, Xiaojiang Wu, Xiaofang Xing, Hong Du, Chunlian Zhou, Qingyun Zhang, Chunyi Hao, Xianzi Wen, Jiafu Ji
BACKGROUND: Lysosome-associated transmembrane-4 beta (LAPTM4B) is an oncogene that participates tumorgenesis in a variety of human solid tumors, and it has two alleles named as LAPTM4B*1 and *2. The present study aimed to identify the association of LAPTM4B genotype with clinicopathological features and prognosis in colorectal and esophageal cancer patients. METHOD: Genotypes of LAPTM4B were determined by PCR in 167 colon cancer cases (72 patients in a discovery cohort and 95 patients in a testing cohort), 160 rectal cancer cases and 164 esophageal cancer cases...
2016: PloS One
https://www.readbyqxmd.com/read/27212036/laptm4b-an-oncogene-in-various-solid-tumors-and-its-functions
#13
REVIEW
Y Meng, L Wang, D Chen, Y Chang, M Zhang, J-J Xu, R Zhou, Q-Y Zhang
The oncogene Lysosome-associated protein transmembrane-4β (LAPTM4B) gene was identified, and the polymorphism region in the 5'-UTR of this gene was certified to be associated with tumor susceptibility. LAPTM4B-35 protein was found to be highly expressed in various solid tumors and could be a poor prognosis marker. The functions of LAPTM4B in solid tumors were also explored. It is suggested that LAPTM4B could promote the proliferation of tumor cells, boost invasion and metastasis, resist apoptosis, initiate autophagy and assist drug resistance...
December 15, 2016: Oncogene
https://www.readbyqxmd.com/read/26984064/far-red-near-infrared-fluorescence-light-up-probes-for-specific-in-vitro-and-in-vivo-imaging-of-a-tumour-related-protein
#14
Chao Chen, Yongquan Hua, Yawen Hu, Yuan Fang, Shenglu Ji, Zhimou Yang, Caiwen Ou, Deling Kong, Dan Ding
As lysosomal protein transmembrane 4 beta (LAPTM4B) is an important biomarker for many solid tumours, development of small-molecule fluorescence light-up probes for detection and imaging of LAPTM4B proteins is particularly valuable. In this work, we reported the design and synthesis of a far-red/near-infrared (FR/NIR) fluorescence light-up probe DBT-2EEGIHGHHIISVG, which could specifically visualize LAPTM4B proteins in cancer cells and tumour-bearing live mice. DBT-2EEGIHGHHIISVG was synthesized by the conjugation of two LAPTM4B-binding peptide ligands (EEGIHGHHIISVG) with one environment-sensitive fluorogen, 4,7-di(thiophen-2-yl)-2,1,3-benzothiadiazole (DBT)...
March 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26526574/predictive-significance-of-combined-laptm4b-and-vegf-expression-in-patients-with-cervical-cancer
#15
Fanling Meng, Shu Tan, Tianbo Liu, Hongtao Song, Ge Lou
Lysosome-associated protein transmembrane 4ß-35 (LAPTM4B-35) is overexpressed in several solid malignancies. This study determines the expression level of LAPTM4B-35 in the cervical cancer during tumor development and progression. The present study investigated the clinicopathological significance of the coexpression of LAPTM4B-35 and VEGF in patients with cervical cancer. Immunohistochemistry was used to evaluate the expression of LAPTM4B-35 and VEGF in 62 cervical intraepithelial neoplasia (CIN) and 226 cervical carcinoma in comparison with 45 normal cervical specimens...
April 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26383850/laptm4b-down-regulation-inhibits-the-proliferation-invasion-and-angiogenesis-of-hela-cells-in-vitro
#16
Fanling Meng, Xiuwei Chen, Hongtao Song, Ge Lou
BACKGROUND/AIMS: LAPTM4B (lysosome-associated protein transmembrane 4 beta) is a novel oncogene with important functions in aggressive human carcinomas, including cervical cancer. However, the specific functions and internal molecular mechanisms associated with this gene in the context of cervical cancer remain unclear. METHODS: In this study, we explored the effects and mechanisms of LAPTM4B on tumor growth, metastasis and angiogenesis in vitro by depletion of LAPTM4B in Hela cell...
2015: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/26343532/laptm4b-is-associated-with-poor-prognosis-in-nsclc-and-promotes-the-nrf2-mediated-stress-response-pathway-in-lung-cancer-cells
#17
Yuho Maki, Junya Fujimoto, Wenhua Lang, Li Xu, Carmen Behrens, Ignacio I Wistuba, Humam Kadara
We recently demonstrated that lysosomal protein transmembrane 4 beta (LAPTM4B) is elevated in non-small cell lung cancers (NSCLCs) and in the surrounding premalignant airway field of cancerization. In the present study, we sought to begin to understand the relevance of LAPTM4B expression and signaling to NSCLC pathogenesis. In situ hybridization analysis of LAPTM4B transcript in tissue microarrays comprised of 368 NSCLCs demonstrated that LAPTM4B expression was significantly increased in smoker compared to non-smoker lung adenocarcinoma tumors (P < 0...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26280656/laptm4b-facilitates-late-endosomal-ceramide-export-to-control-cell-death-pathways
#18
Tomas Blom, Shiqian Li, Andrea Dichlberger, Nils Bäck, Young Ah Kim, Ursula Loizides-Mangold, Howard Riezman, Robert Bittman, Elina Ikonen
Lysosome-associated protein transmembrane-4b (LAPTM4B) associates with poor prognosis in several cancers, but its physiological function is not well understood. Here we use novel ceramide probes to provide evidence that LAPTM4B interacts with ceramide and facilitates its removal from late endosomal organelles (LEs). This lowers LE ceramide in parallel with and independent of acid ceramidase-dependent catabolism. In LAPTM4B-silenced cells, LE sphingolipid accumulation is accompanied by lysosomal membrane destabilization...
October 2015: Nature Chemical Biology
https://www.readbyqxmd.com/read/26247403/lentivirus-mediated-rna-interference-targeting-laptm4b-inhibits-human-ovarian-cancer-cell-invasion-in-vitro
#19
Fanling Meng, Xiuwei Chen, Hongtao Song, Ge Lou, Songbin Fu
LAPTM4B (lysosome-associated protein transmembrane 4 beta) play an important role in several human carcinomas. We examines the effects of RNA interference mediated downregulation of human lysosomal-associated protein transmembrane 4 beta expression on the biological behavior of the human serous adenocarcinoma cell line NIH:OVCAR3. This study investigated the expression level of lysosomal-associated protein transmembrane 4 beta in several ovarian cancer cell lines. RNA interference mediated by recombinant lentiviral vectors expressing an artificial lysosomal-associated protein transmembrane 4 beta miRNA was used to induce long-lasting downregulation of lysosomal-associated protein transmembrane 4 beta gene expression in NIH:OVCAR3 cells...
January 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/26126825/lysosomal-associated-transmembrane-protein-4b-laptm4b-decreases-transforming-growth-factor-%C3%AE-1-tgf-%C3%AE-1-production-in-human-regulatory-t-cells
#20
Caroline Huygens, Stéphanie Liénart, Olivier Dedobbeleer, Julie Stockis, Emilie Gauthy, Pierre G Coulie, Sophie Lucas
Production of active TGF-β1 is one mechanism by which human regulatory T cells (Tregs) suppress immune responses. This production is regulated by glycoprotein A repetitions predominant (GARP), a transmembrane protein present on stimulated Tregs but not on other T lymphocytes (Th and CTLs). GARP forms disulfide bonds with proTGF-β1, favors its cleavage into latent inactive TGF-β1, induces the secretion and surface presentation of GARP·latent TGF-β1 complexes, and is required for activation of the cytokine in Tregs...
August 14, 2015: Journal of Biological Chemistry
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