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https://www.readbyqxmd.com/read/29790290/tacrolimus-prevents-von-willebrand-factor-secretion-by-allostimulated-human-glomerular-endothelium
#1
S Béland, O Désy, R V Ung, P Vallin, E Latulippe, J Riopel, S A De Serres
Little is known about the endothelial injury caused directly by circulating donor-specific antibodies during antibody-mediated rejection. Von Willebrand factor (vWF) is a highly thrombotic glycoprotein stored in Weibel-Palade bodies in endothelial cells. It has been shown that its secretion is triggered by allostimulation. Calcineurin-like phosphatases regulate pathways involved in vWF secretion. Therefore, we hypothesized that tacrolimus would prevent alloantibody-induced glomerular lesions in part via inhibition of vWF secretion from endothelial cells...
May 22, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29786104/correlation-between-the-expression-of-il%C3%A2-18-and-deep-venous-thrombosis
#2
Guangdi Li, Rudan Zhou, Xueling Zhao, Riguang Liu, Chuan Ye
The present study aimed to investigate the effect of the expression of interleukin (IL)‑18 and related markers on deep venous thrombosis (DVT) to examine their correlation. Sprague‑Dawley rats of different models were established and were randomly assigned into three groups. The expression of IL‑18, nuclear factor (NF)‑κB and von Willebrand factor (vWF) were detected in blood samples. The inferior vena cava (IVC) was ligated to establish the DVT model. Rat IL‑18 overexpression and inhibition vectors were constructed...
May 16, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29785664/effect-of-pneumatic-tubing-system-transport-on-platelet-apheresis-units
#3
Jevgenia Zilberman-Rudenko, Frank Z Zhao, Stephanie E Reitsma, Annachiara Mitrugno, Jiaqing Pang, Joseph J Shatzel, Beth Rick, Christina Tyrrell, Wohaib Hasan, Owen J T McCarty, Martin A Schreiber
Platelet apheresis units are transfused into patients to mitigate or prevent bleeding. In a hospital, platelet apheresis units are transported from the transfusion service to the healthcare teams via two methods: a pneumatic tubing system (PTS) or ambulatory transport. Whether PTS transport affects the activity and utility of platelet apheresis units is unclear. We quantified the gravitational forces and transport time associated with PTS and ambulatory transport within our hospital. Washed platelets and supernatants were prepared from platelet apheresis units prior to transport as well as following ambulatory or PTS transport...
May 21, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29785538/stress-phase-angle-regulates-differentiation-of-human-adipose-derived-stem-cells-toward-endothelial-phenotype
#4
Shahrokh Shojaei, Mohammad Tafazzoli-Shadpour, Mohammad Ali Shokrgozar, Nooshin Haghighipour, Fatemeh Hejazi Jahromi
Endothelial cells are subjected to cyclic shear by pulsatile blood flow and pressures due to circumferential stresses. Although most of the researches on this topic have considered the effects of these two biomechanical forces separately or concurrently, few studies have noticed the interaction of these cyclic loadings on endothelial behavior. Negative temporal stress phase angle, defined by the phase lag between cyclic shear and tensile stresses, is an established parameter which is known to have substantial effects on blood vessel remodeling and progression of some serious cardiovascular diseases...
May 21, 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29782915/new-insights-into-the-natural-course-of-knee-osteoarthritis-early-regulation-of-cytokines-and-growth-factors-with-emphasis-on-sex-dependent-angiogenesis-and-tissue-remodeling-a-pilot-study
#5
Kalle Kisand, Ann Tamm, Mare Lintrop, Agu Tamm
OBJECTIVE: This study was conducted to identify cytokine profiles associated with radiographic phenotypes of knee osteoarthritis (rKOA) with a focus on early stage of the disease. METHODS: The pilot population study involved 60 middle-aged patients (mean age 50±7.3y.). Standardized weight-bearing anteroposterior and axial radiographs were used to assess rKOA severity in tibiofemoral (TFJ) of patellofemoral joint (PFJ) by grading system (grades 0-3). Luminex (xMAP® ) technology was used to simultaneously assess 60 biomarkers...
May 18, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29770800/current-and-future-circulating-biomarkers-for-cardiac-amyloidosis
#6
REVIEW
Marco Luciani, Luca Troncone, Federica Del Monte
Cardiac amyloidosis (CA) comprises a heterogeneous group of medical conditions affecting the myocardium. It presents with proteinaceous infiltration with variable degrees of severity, prevalence and evolution. Despite this heterogeneity, erroneous protein folding is the common pathophysiologic process, yielding the formation of a single misfolded protein (monomer) that progressively evolves and ultimately forms amyloid fibers. Additionally, by seeding out from the organs of origin, intermediates called oligomers metastasize and restart the process...
May 17, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29769259/novel-therapeutics-for-hemophilia-and-other-bleeding-disorders
#7
Michael U Callaghan, Robert Sidonio, Steven W Pipe
Hemophilia and von Willebrand disease are the most common congenital bleeding disorders. Treatment for these disorders has focused on replacement of the missing coagulation factor to prevent or treat bleeding. New technologies and insights into hemostasis have driven the development of many promising new therapies for hemophilia and von Willebrand disease. Emerging bypass agents including zymogen-like factor IXa and Xa molecules are in development and a bispecific antibody, emicizumab, demonstrated efficacy in a phase III trial in people with hemophilia A and inhibitors...
May 16, 2018: Blood
https://www.readbyqxmd.com/read/29767844/comorbidities-associated-with-higher-von-willebrand-factor-vwf-levels-may-explain-the-age-related-increase-of-vwf-in-von-willebrand-disease
#8
Ferdows Atiq, Karina Meijer, Jeroen Eikenboom, Karin Fijnvandraat, Eveline P Mauser-Bunschoten, Karin P M van Galen, Marten R Nijziel, Paula F Ypma, Joke de Meris, Britta A P Laros-van Gorkom, Johanna G van der Bom, Moniek P de Maat, Marjon H Cnossen, Frank W G Leebeek
Some comorbidities, such as hypertension, are associated with higher von Willebrand factor (VWF) levels in the general population. No studies have been conducted to assess this association in patients with von Willebrand disease (VWD). Therefore, we studied this association in patients with type 1 (n = 333) and type 2 (n = 203) VWD from the 'WiN" study. VWF antigen (VWF:Ag) was higher in type 1 VWD patients with hypertension [difference: 0·23 iu/ml, 95% confidence interval (CI): 0·11-0·35], diabetes mellitus (0·11 iu/ml, 95% CI: -0·02 to 0·23), cancer (0·14 iu/ml, 95% CI: 0·03-0·25) and thyroid dysfunction (0·14 iu/ml, 95% CI: 0·03-0·26) than in patients without these comorbidities (all corrected for age, sex and blood group)...
May 16, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29760727/expanded-cd133-cells-from-human-umbilical-cord-blood-improved-heart-function-in-rats-after-severe-myocardial-infarction
#9
Alejandro Correa, Gabriel Salles Ottoboni, Alexandra Cristina Senegaglia, Luiz Guilherme Achcar Capriglione, Nelson Itiro Miyague, Lidiane Maria Boldrini Leite, Valderez Ravaglio Jamur, Carmen Lúcia Kuniyoshi Rebelatto, Márcia Olandoski, Paulo Roberto Slud Brofman
Pharmacological approaches are partially effective in limiting infarct size. Cell therapies using a cell population enriched with endothelial progenitor cells (EPCs) CD133+ have opened new perspectives for the treatment of ischemic areas after infarction. This preclinical study evaluated the effect of intramyocardial transplantation of purified or expanded human umbilical cord blood-derived CD133+ cells on the recovery of rats following acute myocardial infarction (AMI). Histology studies, electrocardiogram, and fluorescence in situ hybridization (FISH) were used to evaluate heart recovery...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29760609/identification-of-potential-crucial-genes-and-construction-of-microrna-mrna-negative-regulatory-networks-in-osteosarcoma
#10
Yue Pan, Lingyun Lu, Junquan Chen, Yong Zhong, Zhehao Dai
Background: This study aimed to identify potential crucial genes and construction of microRNA-mRNA negative regulatory networks in osteosarcoma by comprehensive bioinformatics analysis. Methods: Data of gene expression profiles (GSE28424) and miRNA expression profiles (GSE28423) were downloaded from GEO database. The differentially expressed genes (DEGs) and miRNAs (DEMIs) were obtained by R Bioconductor packages. Functional and enrichment analyses of selected genes were performed using DAVID database...
2018: Hereditas
https://www.readbyqxmd.com/read/29751951/biochemical-characterization-and-immunogenicity-of-neureight-a-recombinant-full-length-factor-viii-produced-by-fed-batch-process-in-disposable-bioreactors
#11
Sandrine Delignat, Ivan Peyron, Maria El Ghazaly, Srinivas V Kaveri, Jan Rohde, Frank Mueller, Sebastien Lacroix-Desmazes
Hemophilia A is a X-linked recessive bleeding disorder consecutive to the lack of circulating pro-coagulant factor VIII (FVIII). The most efficient strategy to treat or prevent bleeding in patients with hemophilia A relies on replacement therapy using exogenous FVIII. Commercially available recombinant FVIII are produced using an expensive perfusion technology in stainless steel fermenters. A fed-batch fermentation technology was recently developed to produce 'Neureight', a full-length recombinant human FVIII, in Chinese hamster ovary (CHO) cells...
May 5, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29747831/arterial-pulsatility-and-circulating-von-willebrand-factor-in-patients-on-mechanical-circulatory-support
#12
Flavien Vincent, Antoine Rauch, Valentin Loobuyck, Emmanuel Robin, Christoph Nix, André Vincentelli, David M Smadja, Pascal Leprince, Julien Amour, Gilles Lemesle, Hugues Spillemaeker, Nicolas Debry, Christian Latremouille, Piet Jansen, Antoine Capel, Mouhamed Moussa, Natacha Rousse, Guillaume Schurtz, Cédric Delhaye, Camille Paris, Emmanuelle Jeanpierre, Annabelle Dupont, Delphine Corseaux, Mickaël Rosa, Yoann Sottejeau, Svenja Barth, Claudia Mourran, Valérie Gomane, Augustin Coisne, Marjorie Richardson, Claudine Caron, Cristian Preda, Alexandre Ung, Alain Carpentier, Thomas Hubert, Cécile Denis, Bart Staels, Peter J Lenting, Eric Van Belle, Sophie Susen
BACKGROUND: The main risk factor for bleeding in patients with continuous-flow mechanical circulatory support (CF-MCS) is the acquired von Willebrand factor (VWF) defect related to the high shear-stress forces developed by these devices. Although a higher bleeding rate has been reported in CF-MCS recipients who had reduced pulsatility, the relation between pulsatility and the VWF defect has never been studied. OBJECTIVES: The purpose of this study was to investigate the relation between pulsatility and VWF under CF-MCS...
May 15, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29743402/-durable-remission-attained-with-rituximab-therapy-in-a-patient-with-acquired-von-willebrand-syndrome-associated-with-cd20-positive-lymphoproliferative-disorder
#13
Honami Kurahashi, Yoshinari Kawabata, Yoshihiro Michishita, Atsushi Kitabayashi, Takahiro Kobayashi, Akihiro Kitadate, Naoto Takahashi
A 61-year-old female with no history of bleeding was admitted to our hospital owing to persistent bleeding after the left knee joint injection and activated partial thromboplastin time prolongation. Subsequent coagulation tests revealed a critically declined level of the von Willebrand factor (VWF) antigen (<10%) and activity (<10%) measurement besides a significantly declined factor VIII activity (4%). Despite diagnosing her with acquired von Willebrand syndrome (AvWS) and managing her bleeding with desmopressin acetate hydrate (DDAVP), we could not precisely make a definitive diagnosis the underlying disorder...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29742318/a-comparative-analysis-of-different-automated-von-willebrand-factor-glycoprotein-ib-binding-activity-assays-in-well-typed-von-willebrand-disease-patients
#14
I Vangenechten, K Mayger, P Smejkal, O Zapletal, J J Michiels, G W Moore, A Gadisseur
BACKGROUND: von Willebrand Disease (VWD) is an inherited bleeding disorder caused by quantitative (type 1, 3) or qualitative (type 2) von Willebrand factor (VWF) defect. VWD diagnosis and classification require numerous laboratory tests. VWF: Glycoprotein Ib (GPIb)-binding activity assays are used to distinguish type 1 from type 2 VWD. OBJECTIVES: Three different automated VWF:GPIb-binding activity assays were compared. PATIENTS AND METHODS: BC-VWF:RCo (Siemens Healthcare Diagnostics), HemosIL® VWF:RCo (Instrumentation Laboratory) and INNOVANCE® VWF:Ac (Siemens Healthcare Diagnostics) were performed in a well typed VWD cohort (n=142)...
May 9, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29741685/association-between-the-severity-of-acquired-von-willebrand-syndrome-and-gastrointestinal-bleeding-after-continuous-flow-left-ventricular-assist-device-implantation
#15
Ko Sakatsume, Kenki Saito, Masatoshi Akiyama, Konosuke Sasaki, Satoshi Kawatsu, Goro Takahashi, Osamu Adachi, Shunsuke Kawamoto, Hisanori Horiuchi, Yoshikatsu Saiki
OBJECTIVES: Acquired von Willebrand syndrome, characterized by the reduction in von Willebrand factor (vWF) large multimers, has recently been considered as one of the causes of gastrointestinal bleeding (GIB). It remains unclear whether its haematological severity is linked with susceptibility to bleeding because the definition of the haematological severity of acquired von Willebrand syndrome has not been precisely determined. This study sought to establish a quantitative methodology to assess the haematological severity of acquired von Willebrand syndrome and to define the threshold for occurrence of GIB in patients implanted with left ventricular assist devices (LVADs)...
May 8, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29737212/baicalein-ameliorates-pulmonary-arterial-hypertension-caused-by-monocrotaline-through-downregulation-of-et-1-and-et-a-r-in-pneumonectomized-rats
#16
Wen-Lin Hsu, Yu-Chieh Lin, Jing-Ren Jeng, Heng-Yuan Chang, Tz-Chong Chou
Baicalein (BE) extracted from Scutellaria baicalensis Georgi is able to alleviate various cardiovascular and inflammatory diseases. However, the effects of BE on pulmonary arterial hypertension (PAH) remain unknown. Therefore, the present study aimed to examine whether BE ameliorates pneumonectomy and monocrotaline-induced PAH in rats and further investigate the underlying molecular mechanisms. Administration of BE greatly attenuated the development of PAH as evidenced by an improvement of its characteristic features, including elevation of right ventricular systolic pressure, right ventricular hypertrophy, and pulmonary vascular remodeling...
May 8, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29734512/correction-of-a-dominant-negative-von-willebrand-factor-multimerization-defect-by-small-interfering-rnas-mediated-allele-specific-inhibition-of-mutant-von-willebrand-factor
#17
A de Jong, R J Dirven, J A Oud, D Tio, B J M van Vlijmen, J Eikenboom
BACKGROUND: Treatment of the bleeding disorder von Willebrand disease (VWD) focusses on increasing von Willebrand factor (VWF) levels through administration of desmopressin or VWF-containing concentrates. Both therapies leave production of mutant VWF unhindered which may have additional consequences, like thrombocytopenia in VWD type 2B, competition between mutant and normal VWF for platelet receptors, and potential development of intestinal angiodysplasia. Most VWD is caused by dominant-negative mutations in VWF and we hypothesize that diminishing expression of mutant VWF positively affects VWD phenotypes...
May 7, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29729720/small-intestinal-lymphatic-hypoplasia-in-three-dogs-with-clinical-signs-of-protein-losing-enteropathy
#18
J M Malatos, N A Kurpios, G E Duhamel
Intestinal lymphatic hypoplasia (ILH) is a rare but well-documented cause of protein-losing enteropathy (PLE) in human infants. To our knowledge, this condition has not been reported previously in veterinary medicine. Here we report the clinical and histopathological findings in three dogs that presented with clinical signs of PLE. The onset of PLE was early in an 18-month-old Great Pyrenees, while the other two dogs, a pug and a Tibetan terrier, had a later onset at 4 and 12 years of age, respectively. The presence of intestinal lymphatic and blood vessels was assessed by immunohistochemistry for human prospero homeobox 1 (prox-1), a lymphatic endothelial nuclear transcription factor and human von Willebrand factor (vWf), a marker of vascular endothelial cells, respectively...
April 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29729651/role-of-von-willebrand-factor-and-adamts13-in-early-brain-injury-after-experimental-subarachnoid-hemorrhage
#19
H Wan, Y Wang, J Ai, S Brathwaite, H Ni, R L Macdonald, E M Hol, J C M Meijers, M D I Vergouwen
BACKGROUND: Early brain injury is an important determinant of poor functional outcome and case-fatality after aneurysmal subarachnoid hemorrhage (SAH) and associated with early platelet aggregation. No treatment exists for early brain injury after SAH. We investigated if von Willebrand Factor (VWF) is involved in the pathogenesis of early brain injury, and if ultra-early treatment with recombinant ADAMTS13 (rADAMTS13) reduces early brain injury after experimental SAH. METHODS: Experimental SAH in mice was induced by prechiasmatic injection of non-anticoagulated blood from a littermate...
May 5, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29729167/the-dependence-of-the-endothelial-function-on-comorbid-states-in-patients-with-asthma
#20
Galyna V Yeryomenko
OBJECTIVE: Introduction: the purpose of the research consisted in the study of the functional state of the endothelium in patients having persistent asthma (A) with an uncontrolled course in combination with diabetes mellitus type 2 (DM2T) and obesity (O) The aim: on the basis of a complex study of nitric oxide metabolites (nitrosothiols, S-NO), von Willebrand factor (VWF) and endothelin-1 (EТ-1). PATIENTS AND METHODS: Materials and methods: The study involved 90 A patients with comorbid states, who were divided into 3 groups...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
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