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https://www.readbyqxmd.com/read/27662529/treatment-of-traumatic-brain-injury-with-17%C3%AE-ethinylestradiol-3-sulfate-in-a-rat-model
#1
Harrison Kim, Tao Yu, Betul Cam-Etoz, Thomas van Groen, William J Hubbard, Irshad H Chaudry
OBJECTIVE 17α-ethynylestradiol-3-sulfate (EE-3-SO4) is a highly water-soluble synthetic estrogen that has an extended half-life (∼ 10 hours) over that of naturally occurring estrogen (∼ 10 minutes). In this study, EE-3-SO4 was evaluated in a lateral fluid percussion-induced traumatic brain injury (TBI) model in rats. METHODS A total of 9 groups of Sprague-Dawley rats underwent craniectomy. Twenty-four hours later, lateral fluid percussion was applied to 6 groups of animals to induce TBI; the remaining 3 groups served as sham control groups...
September 23, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27601907/brain-tissue-partial-pressure-of-oxygen-predicts-the-outcome-of-severe-traumatic-brain-injury-under-mild-hypothermia-treatment
#2
Hongtao Sun, Maohua Zheng, Yanmin Wang, Yunfeng Diao, Wanyong Zhao, Zhengjun Wei
OBJECTIVE: The aim of this study was to investigate the clinical significance and changes of brain tissue partial pressure of oxygen (PbtO2) in the course of mild hypothermia treatment (MHT) for treating severe traumatic brain injury (sTBI). METHODS: There were 68 cases with sTBI undergoing MHT. PbtO2, intracranial pressure (ICP), jugular venous oxygen saturation (SjvO2), and cerebral perfusion pressure (CPP) were continuously monitored, and clinical outcomes were evaluated using the Glasgow Outcome Scale score...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27435860/brain-tissue-oxygen-monitoring-and-the-intersection-of-brain-and-lung-a-comprehensive-review
#3
REVIEW
Laura B Ngwenya, John F Burke, Geoffrey T Manley
Traumatic brain injury is a problem that affects millions of Americans yearly and for which there is no definitive treatment that improves outcome. Continuous brain tissue oxygen (PbtO2 ) monitoring is a complement to traditional brain monitoring techniques, such as intracranial pressure and cerebral perfusion pressure. PbtO2 monitoring has not yet become a clinical standard of care, due to several unresolved questions. In this review, we discuss the rationale and technology of PbtO2 monitoring. We review the literature, both historic and current, and show that continuous PbtO2 monitoring is feasible and useful in patient management...
September 2016: Respiratory Care
https://www.readbyqxmd.com/read/27356551/altered-hypermetabolic-response-to-cortical-spreading-depolarizations-after-traumatic-brain-injury-in-rats
#4
Baptiste Balança, Anne Meiller, Laurent Bezin, Jens P Dreier, Stéphane Marinesco, Thomas Lieutaud
Spreading depolarizations are waves of near-complete breakdown of neuronal transmembrane ion gradients, free energy starving, and mass depolarization. Spreading depolarizations in electrically inactive tissue are associated with poor outcome in patients with traumatic brain injury. Here, we studied changes in regional cerebral blood flow and brain oxygen (PbtO2), glucose ([Glc]b), and lactate ([Lac]b) concentrations in rats, using minimally invasive real-time sensors. Rats underwent either spreading depolarizations chemically triggered by KCl in naïve cortex in absence of traumatic brain injury or spontaneous spreading depolarizations in the traumatic penumbra after traumatic brain injury, or a cluster of spreading depolarizations triggered chemically by KCl in a remote window from which spreading depolarizations invaded penumbral tissue...
June 29, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27290043/a-novel-prognostic-marker-in-severe-traumatic-brain-injury-patients-pbto2-pao2-ratio
#5
R Badenes, A Lozano, F Bilotta, A Cueva, B Ortolá, A Maruenda, J Belda
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27165902/plateau-waves-of-intracranial-pressure-and-partial-pressure-of-cerebral-oxygen
#6
Erhard W Lang, Magdalena Kasprowicz, Peter Smielewski, John Pickard, Marek Czosnyka
This study investigates 55 intracranial pressure (ICP) plateau waves recorded in 20 patients after severe traumatic brain injury (TBI) with a focus on a moving correlation coefficient between mean arterial pressure (ABP) and ICP, called PRx, which serves as a marker of cerebrovascular reactivity, and a moving correlation coefficient between ABP and cerebral partial pressure of oxygen (pbtO2), called ORx, which serves as a marker for cerebral oxygen reactivity. ICP and ICPamplitude increased significantly during the plateau waves, whereas CPP and pbtO2 decreased significantly...
2016: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/27165893/brain-oxygen-relationship-to-cerebral-perfusion-pressure-depends-on-tip-location-and-time-window-can-brain-o2-be-an-adjunctive-modality-for-determining-optimal-cpp
#7
Soojin Park, Marek Czosnyka, Peter Smielewski
Controversy exists regarding the brain tissue oxygen (PbtO2) monitor's optimal tip location and what it actually measures. Recent work [2] identified a "PbtO2 change point" (CPPbt), below which PbtO2 displays pressure-passive behavior, showing significant correlation with optimal cerebral perfusion pressure (CPPopt) as defined by the pressure reactivity index (PRx). This would further support the concept of CPPopt [1] as an individualized target. We endeavored to validate these findings and further explore the relationship between PbtO2 and suboptimal CPP...
2016: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/27165868/early-changes-in-brain-oxygen-tension-may-predict-outcome-following-severe-traumatic-brain-injury
#8
J K Rhodes, S Chandrasekaran, P J Andrews
We report on the change in brain oxygen tension (PbtO2) over the first 24 h of monitoring in a series of 25 patients with severe traumatic brain injury (TBI) and relate this to outcome. The trend in PbtO2 for the whole group was to increase with time (mean PbtO2 17.4 [1.75] vs 24.7 [1.60] mmHg, first- vs last-hour data, respectively; p = 0.002). However, a significant increase in PbtO2 occurred in only 17 patients (68 %), all surviving to intensive care unit discharge (p = 0.006). Similarly, a consistent increase in PbtO2 with time occurred in only 13 patients, the correlation coefficient for PbtO2 versus time being ≥0...
2016: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/27095434/brain-multimodality-monitoring-updated-perspectives
#9
REVIEW
David Roh, Soojin Park
The challenges posed by acute brain injury (ABI) involve the management of the initial insult in addition to downstream inflammation, edema, and ischemia that can result in secondary brain injury (SBI). SBI is often subclinical, but can be detected through physiologic changes. These changes serve as a surrogate for tissue injury/cell death and are captured by parameters measured by various monitors that measure intracranial pressure (ICP), cerebral blood flow (CBF), brain tissue oxygenation (PbtO2), cerebral metabolism, and electrocortical activity...
June 2016: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/27095125/monitoring-of-brain-oxygenation-during-hypothermic-cpr-a-prospective-porcine-study
#10
Gabriel Putzer, Patrick Braun, Giacomo Strapazzon, Martha Toferer, Miriam Mulino, Bernhard Glodny, Markus Falk, Hermann Brugger, Peter Paal, Raimund Helbok, Peter Mair
BACKGROUND AND AIM: Limited data are available concerning the impact of CPR interventions on cerebral oxygenation during hypothermic cardiac arrest. We therefore studied cerebral perfusion pressure (CPP), brain tissue oxygen tension (PbtO2), cerebral venous oxygen saturation (ScvO2) and regional cerebral oxygen saturation (rSO2) in an animal model of hypothermic CPR. We also assessed the correlation between rSO2 and CPP, PbtO2 and ScvO2 to clarify whether near-infrared spectroscopy (NIRS) may be used to non-invasively monitor changes in cerebral oxygenation during hypothermic CPR...
July 2016: Resuscitation
https://www.readbyqxmd.com/read/26998778/brain-hypoxia-is-exacerbated-in-hypobaria-during-aeromedical-evacuation-in-swine-with-traumatic-brain-injury
#11
Anke H Scultetus, Ashraful Haque, Steve J Chun, Brittany Hazzard, Richard T Mahon, Martin J Harssema, Charles R Auker, Paula Moon-Massat, Debra L Malone, Richard M McCarron
BACKGROUND: There is inadequate information on the physiologic effects of aeromedical evacuation on wounded war fighters with traumatic brain injury (TBI). At altitudes of 8,000 ft, the inspired oxygen is lower than standard sea level values. In troops experiencing TBI, this reduced oxygen may worsen or cause secondary brain injury. We tested the hypothesis that the effects of prolonged aeromedical evacuation on critical neurophysiologic parameters (i.e., brain oxygenation [PbtO2]) of swine with a fluid percussion injury/TBI would be detrimental compared with ground (normobaric) transport...
July 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/26971295/acute-effects-of-intraventricular-nicardipine-on-cerebral-hemodynamics-a-preliminary-finding
#12
Sang-Bae Ko, H Alex Choi, Raimund Helbok, Pedro Kurtz, J Michael Schmidt, Neeraj Badjatia, Jan Claassen, E Sander Connolly, Stephan A Mayer, Kiwon Lee
OBJECTIVE: Intraventricular nicardipine (IVTN) is a treatment option for severe vasospasm in patients with subarachnoid hemorrhage (SAH). However, its acute effects on cerebral hemodynamics have not been studied in detail. METHODS: Between June 2008 and December 2010, IVTN was administered (mainly 4mg every 8h) to 11 SAH patients (54 doses) with multimodality monitoring for refractory vasospasm. Retrospective analyses on physiological parameters were made from baseline and up to 6h after IVTN injection...
May 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/26848909/brain-tissue-oxygen-tension-and-its-response-to-physiological-manipulations-influence-of-distance-from-injury-site-in-a-swine-model-of-traumatic-brain-injury
#13
Gregory W J Hawryluk, Nicolas Phan, Adam R Ferguson, Diane Morabito, Nikita Derugin, Campbell L Stewart, M Margaret Knudson, Geoffrey Manley, Guy Rosenthal
OBJECTIVE The optimal site for placement of tissue oxygen probes following traumatic brain injury (TBI) remains unresolved. The authors used a previously described swine model of focal TBI and studied brain tissue oxygen tension (PbtO2) at the sites of contusion, proximal and distal to contusion, and in the contralateral hemisphere to determine the effect of probe location on PbtO2 and to assess the effects of physiological interventions on PbtO2 at these different sites. METHODS A controlled cortical impact device was used to generate a focal lesion in the right frontal lobe in 12 anesthetized swine...
February 5, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/26794250/perfluorocarbon-nvx-108-increased-cerebral-oxygen-tension-after-traumatic-brain-injury-in-rats
#14
Saad H Mullah, Biswajit K Saha, Rania Abutarboush, Peter B Walker, Ashraful Haque, Francoise G Arnaud, Brittany Hazzard, Charles R Auker, Richard M McCarron, Anke H Scultetus, Paula Moon-Massat
BACKGROUND: Hypoxia is a critical secondary injury mechanism in traumatic brain injury (TBI), and early intervention to alleviate post-TBI hypoxia may be beneficial. NVX-108, a dodecafluoropentane perfluorocarbon, was screened for its ability to increase brain tissue oxygen tension (PbtO2) when administered soon after TBI. METHODS: Ketamine-acepromazine anesthetized rats ventilated with 40% oxygen underwent moderate controlled cortical impact (CCI)-TBI at time 0 (T0)...
March 1, 2016: Brain Research
https://www.readbyqxmd.com/read/26521677/brain-tissue-oxygen-evaluation-by-wireless-near-infrared-spectroscopy
#15
Che-Chuan Wang, Jinn-Rung Kuo, Yu-Chih Chen, Chung-Ching Chio, Jhi-Joung Wang, Bor-Shyh Lin
BACKGROUND: Monitoring the partial pressure of oxygen in brain tissue (PbtO2) is an important tool for traumatic brain injury (TBI) but is invasive and inconvenient for real time monitoring. Near-infrared spectroscopy (NIRS), which can monitor hemoglobin parameters in the brain tissue, has been used widely as a noninvasive tool for assessing cerebral ischemia and hypoxia. Therefore, it may have the potential as a noninvasive tool for estimating the change of PbtO2. In this study, a novel wireless NIRS system was designed to monitor hemoglobin parameters of rat brains under different impact strengths and was used to estimate the change of PbtO2 noninvasively in TBI...
February 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/26406423/preclinical-evaluation-of-injectable-reduced-hydroxocobalamin-as-an-antidote-to-acute-carbon-monoxide-poisoning
#16
Joseph D Roderique, Christopher S Josef, Alden H Newcomb, Penny S Reynolds, Leonardo G Somera, Bruce D Spiess
BACKGROUND: Current management of acute inhalational carbon monoxide (CO) toxicity includes hyperbaric or normobaric O2 therapy. However, efficacy has not been established. The purpose of this study was to establish therapeutic proof of concept for a novel injectable antidote consisting of the combination of hydroxocobalamin and ascorbic acid into a reduced form (B12r) as demonstrated by clinically significant increase (>500 ppm) in CO2 production, reduced carboxyhemoglobin (COHgb) half-life (COHgb t1/2), and increased cerebral O2 delivery and attenuation of CO-induced microglial damage in a preclinical rodent model of CO toxicity...
October 2015: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/26337700/low-brain-oxygenation-and-differences-in-neuropsychological-outcomes-following-severe-pediatric-tbi
#17
L E Schrieff-Elson, K G F Thomas, U K Rohlwink, A A Figaji
PURPOSE: Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in children. Preventing secondary injury by controlling physiological parameters (e.g. intracranial pressure [ICP], cerebral perfusion pressure [CPP] and brain tissue oxygen [PbtO2]) has a potential to improve outcome. Low PbtO2 is independently associated with poor clinical outcomes in both adults and children. However, no studies have investigated associations between low PbtO2 and neuropsychological and behavioural outcomes following severe pediatric TBI (pTBI)...
December 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/26195087/the-effect-of-packed-red-blood-cell-transfusion-on-cerebral-oxygenation-and-metabolism-after-subarachnoid-hemorrhage
#18
Pedro Kurtz, Raimund Helbok, Jan Claassen, J Michael Schmidt, Luis Fernandez, R Morgan Stuart, E Sander Connolly, Kiwon Lee, Stephan A Mayer, Neeraj Badjatia
BACKGROUND: Anemia adversely affects cerebral oxygenation and metabolism after subarachnoid hemorrhage (SAH) and is also associated with poor outcome. There is limited evidence to support the use of packed red blood cell (PRBC) transfusion to optimize brain homeostasis after SAH. The aim of this study was to investigate the effect of transfusion on cerebral oxygenation and metabolism in patients with SAH. METHODS: This was a prospective observational study in a neurological intensive care unit of a university hospital...
February 2016: Neurocritical Care
https://www.readbyqxmd.com/read/26182025/179%C3%A2-brain-tissue-oxygen-tension-and-its-response-to-physiological-manipulations-is-dependent-on-distance-from-injury-site-in-a-swine-model-of-traumatic-brain-injury
#19
Gregory W J Hawryluk, Nicolas Phan, Adam Ferguson, Diane Morabito, Nikita Derugin, Campbell Stewart, Margaret Knudson, Geoffrey T Manley, Guy Rosenthal
INTRODUCTION: The optimal site for placement of tissue oxygen probes following traumatic brain injury (TBI) remains unresolved. We studied brain tissue oxygen tension (PbtO2) at the sites of contusion, proximal and distal to contusion, and in the contralateral hemisphere to determine the effect of probe location on PbtO2 and to assess the effects of physiological interventions on PbtO2 at these different sites. METHODS: A controlled cortical impact (CCI) device was used to generate a focal lesion in the right frontal lobe in 12 anesthetized swine...
August 2015: Neurosurgery
https://www.readbyqxmd.com/read/26161914/cerebral-vasoactivity-and-oxygenation-with-oxygen-carrier-m101-in-rats
#20
Paula Moon-Massat, Saad H Mullah, Rania Abutarboush, Biswajit K Saha, Georgina Pappas, Ashraful Haque, Charles Auker, Richard M McCarron, Francoise Arnaud, Anke Scultetus
The severity of traumatic brain injury (TBI) may be reduced if oxygen can be rapidly provided to the injured brain. This study evaluated if the oxygen-carrier M101 causes vasoconstricton of pial vasculature in healthy rats (Experiment 1) and if M101 improves brain tissue oxygen (PbtO2) in rats with controlled-cortical impact (CCI)-TBI (Experiment 2). M101 (12.5 ml/kg IV over 2 h) caused a mild (9 mm Hg) increase in the mean arterial blood pressure (MAP) of healthy rats without constriction of cerebral pial arterioles...
July 10, 2015: Journal of Neurotrauma
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