Jean-François Payen, Yoann Launey, Russell Chabanne, Samuel Gay, Gilles Francony, Laurent Gergele, Emmanuel Vega, Ambroise Montcriol, David Couret, Vincent Cottenceau, Sebastien Pili-Floury, Clement Gakuba, Emmanuelle Hammad, Gerard Audibert, Julien Pottecher, Claire Dahyot-Fizelier, Lamine Abdennour, Tobias Gauss, Marion Richard, Antoine Vilotitch, Jean-Luc Bosson, Pierre Bouzat
BACKGROUND: Optimisation of brain oxygenation might improve neurological outcome after traumatic brain injury. The OXY-TC trial explored the superiority of a strategy combining intracranial pressure and brain tissue oxygen pressure (PbtO2 ) monitoring over a strategy of intracranial pressure monitoring only to reduce the proportion of patients with poor neurological outcome at 6 months. METHODS: We did an open-label, randomised controlled superiority trial at 25 French tertiary referral centres...
November 2023: Lancet Neurology