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https://www.readbyqxmd.com/read/27908170/high-resolution-digital-autoradiographic-and-dosimetric-analysis-of-heterogeneous-radioactivity-distribution-in-xenografted-prostate-tumors
#1
Oskar V Timmermand, Jenny Nilsson, Sven-Erik Strand, Jörgen Elgqvist
PURPOSE: The first main aim of this study was to illustrate the absorbed dose rate distribution from (177)Lu in sections of xenografted prostate cancer (PCa) tumors using high resolution digital autoradiography (DAR) and compare it with hypothetical identical radioactivity distributions of (90)Y or 7 MeV alpha-particles. Three dosimetry models based on either dose point kernels or Monte Carlo simulations were used and evaluated. The second and overlapping aim, was to perform DAR imaging and dosimetric analysis of the distribution of radioactivity, and hence the absorbed dose rate, in tumor sections at an early time point after injection during radioimmunotherapy using (177)Lu-h11B6, directed against the human kallikrein 2 antigen...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27908157/volumetry-of-low-contrast-liver-lesions-with-ct-investigation-of-estimation-uncertainties-in-a-phantom-study
#2
Qin Li, Yongguang Liang, Qiao Huang, Min Zong, Benjamin Berman, Marios A Gavrielides, Lawrence H Schwartz, Binsheng Zhao, Nicholas Petrick
PURPOSE: To evaluate the performance of lesion volumetry in hepatic CT as a function of various imaging acquisition parameters. METHODS: An anthropomorphic abdominal phantom with removable liver inserts was designed for this study. Two liver inserts, each containing 19 synthetic lesions with varying diameter (6-40 mm), shape, contrast (10-65 HU), and both homogenous and mixed-density were designed to have background and lesion CT values corresponding to arterial and portal-venous phase imaging, respectively...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27899138/the-impact-of-oxytocin-administration-on-brain-activity-a-systematic-review-and-meta-analysis-protocol
#3
Daniel S Quintana, Tim Outhred, Lars T Westlye, Gin S Malhi, Ole A Andreassen
BACKGROUND: Converging evidence demonstrates the important role of the neuropeptide hormone oxytocin (OT) in human behaviour and cognition. Intranasal OT administration has been shown to improve several aspects of social communication, such as the theory of mind performance and gaze to the eye region, and reduce anxiety and related negative cognitive appraisals. While this early research has demonstrated the potential for intranasal OT to treat psychiatric illnesses characterized by social impairments, the neurobiological mechanisms are not well known...
November 29, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27898771/dissection-of-genetic-factors-underlying-wheat-kernel-shape-and-size-in-an-elite-%C3%A3-nonadapted-cross-using-a-high-density-snp-linkage-map
#4
Ajay Kumar, E E Mantovani, R Seetan, A Soltani, M Echeverry-Solarte, S Jain, S Simsek, D Doehlert, M S Alamri, E M Elias, S F Kianian, M Mergoum
Wheat kernel shape and size has been under selection since early domestication. Kernel morphology is a major consideration in wheat breeding, as it impacts grain yield and quality. A population of 160 recombinant inbred lines (RIL), developed using an elite (ND 705) and a nonadapted genotype (PI 414566), was extensively phenotyped in replicated field trials and genotyped using Infinium iSelect 90K assay to gain insight into the genetic architecture of kernel shape and size. A high density genetic map consisting of 10,172 single nucleotide polymorphism (SNP) markers, with an average marker density of 0...
March 2016: Plant Genome
https://www.readbyqxmd.com/read/27885583/using-gis-mapping-to-target-public-health-interventions-examining-birth-outcomes-across-gis-techniques
#5
E L MacQuillan, A B Curtis, K M Baker, R Paul, Y O Back
With advances in spatial analysis techniques, there has been a trend in recent public health research to assess the contribution of area-level factors to health disparity for a number of outcomes, including births. Although it is widely accepted that health disparity is best addressed by targeted, evidence-based and data-driven community efforts, and despite national and local focus in the U.S. to reduce infant mortality and improve maternal-child health, there is little work exploring how choice of scale and specific GIS visualization technique may alter the perception of analyses focused on health disparity in birth outcomes...
November 24, 2016: Journal of Community Health
https://www.readbyqxmd.com/read/27872803/local-food-environment-and-fruit-and-vegetable-consumption-an-ecological-study
#6
Mariana Carvalho Menezes, Bruna Vieirade Lima Costa, Cláudia Di Lorenzo Oliveira, Aline Cristine Souza Lopes
Ecological studies are essential for understanding the environment-diet relationship. The purpose of this study was to describe environmental conditions and their relationship with fruit and vegetable (FV) consumption among Brazilian public health service users in the city of Belo Horizonte. We evaluated food stores contained within 1600 m buffer zones at 18 Health Academy Programme sites, from 2013 to 2014. Variables at the community (density, proximity and type) and the consumer (sectional location of FV; availability, quality, variety, price and advertising of FV and ultra-processed foods) nutrition environment were measured by direct observation, while aggregate data from users (income and FV consumption) were obtained by interview...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27869918/spatial-and-temporal-analysis-of-aids-cases-in-brazil-1996-2011-increased-risk-areas-over-time
#7
Artur Iuri Alves de Sousa, Vitor Laerte Pinto
OBJECTIVE: to identify areas with greater risk of AIDS transmission in Brazil. METHODS: this is an ecological study involving georeference of AIDS cases incidence, prevalence and density in Brazilian municipalities using the Kernel method for the periods 1996-1999, 2000-2003, 2004-2007 and 2008-2011. RESULTS: 633,512 AIDS cases were reported between 1996-2011; between 2008-2011, there was increased risk of AIDS transmission in Recife-João Pessoa region, the emergence of areas with average density in the regions of Belém, São Luís, Maceió, Aracaju and Salvador, and a decline in the intensity of risk in São Paulo, Campinas and Ribeirão Preto; prevalence rates were most concentrated in the Southeast, South and Midwest regions of the country...
July 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27867725/phase-stretch-transform-for-super-resolution-localization-microscopy
#8
Tali Ilovitsh, Bahram Jalali, Mohammad H Asghari, Zeev Zalevsky
Super-resolution localization microscopy has revolutionized the observation of living structures at the cellular scale, by achieving a spatial resolution that is improved by more than an order of magnitude compared to the diffraction limit. These methods localize single events from isolated sources in repeated cycles in order to achieve super-resolution. The requirement for sparse distribution of simultaneously activated sources in the field of view dictates the acquisition of thousands of frames in order to construct the full super-resolution image...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27849272/community-viral-load-of-hiv-in-brazil-2007-2011-potential-impact-of-highly-active-antiretroviral-therapy-haart-in-reducing-new-infections
#9
Artur Iuri Alves de Sousa, Vitor Laerte Pinto
Objectives: To estimate the human immunodeficiency virus (HIV) viral load in the Brazilian population and to assess the potential impact of highly active antiretroviral therapy (HAART) in reducing new infections to build evidences and to gather information to support health policies. Methods: Spatial analysis and modeling tools were used to describe the existing patterns of the viral load density, using the Kernel method. Data on viral load and treatment were retrieved from the databases Laboratory Tests Control System (SISCEL), which contains information on the individual's history of viral load, and Medication Logistics Control System (SICLOM), which controls the dispensing of drugs used for antiretroviral therapy...
July 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/27848039/antiviral-susceptibility-profile-of-influenza-a-viruses-keep-an-eye-on-immunocompromised-patients-under-prolonged-treatment
#10
A Kossyvakis, A-F A Mentis, K Tryfinopoulou, V Pogka, A Kalliaropoulos, E Antalis, T Lytras, A Meijer, S Tsiodras, P Karakitsos, A F Mentis
There was an increase in severe and fatal influenza cases in Greece during the 2011-2015 post-pandemic period. To investigate causality, we determined neuraminidase (NA) inhibitor susceptibility and resistance-conferring NA and hemagglutinin (HA) mutations in circulating influenza type A viruses during the pandemic (2009-2010) and post-pandemic periods in Greece. One hundred thirty-four influenza A(H1N1)pdm09 and 95 influenza A(H3N2) viruses submitted to the National Influenza Reference Laboratory of Southern Greece were tested for susceptibility to oseltamivir and zanamivir...
November 15, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27842488/genetic-architecture-of-the-maize-kernel-row-number-revealed-by-combining-qtl-mapping-using-a-high-density-genetic-map-and-bulked-segregant-rna-sequencing
#11
Changlin Liu, Qiang Zhou, Le Dong, Hui Wang, Fang Liu, Jianfeng Weng, Xinhai Li, Chuanxiao Xie
BACKGROUND: The maize kernel row number (KRN) is a key component that contributes to grain yield and has high broad-sense heritability (H (2) ). Quantitative trait locus/loci (QTL) mapping using a high-density genetic map is a powerful approach to detecting loci that are responsible for traits of interest. Bulked segregant ribonucleic acid (RNA) sequencing (BSR-seq) is another rapid and cost-effective strategy to identify QTL. Combining QTL mapping using a high-density genetic map and BSR-seq may dissect comprehensively the genetic architecture underlying the maize KRN...
November 14, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27831865/the-spurs-algorithm-for-resampling-an-irregularly-sampled-signal-onto-a-cartesian-grid
#12
Amir Kiperwas, Daniel Rosenfeld, Yonina C Eldar
We present an algorithm for resampling a function from its values on a non-Cartesian grid onto a Cartesian grid. This problem arises in many applications such as MRI, CT, radio astronomy and geophysics. Our algorithm, termed SParse Uniform ReSampling (SPURS), employs methods from modern sampling theory to achieve a small approximation error while maintaining low computational cost. The given non-Cartesian samples are projected onto a selected intermediate subspace, spanned by integer translations of a compactly supported kernel function...
November 1, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27826224/graph-theory-based-brain-connectivity-for-automatic-classification-of-multiple-sclerosis-clinical-courses
#13
Gabriel Kocevar, Claudio Stamile, Salem Hannoun, François Cotton, Sandra Vukusic, Françoise Durand-Dubief, Dominique Sappey-Marinier
Purpose: In this work, we introduce a method to classify Multiple Sclerosis (MS) patients into four clinical profiles using structural connectivity information. For the first time, we try to solve this question in a fully automated way using a computer-based method. The main goal is to show how the combination of graph-derived metrics with machine learning techniques constitutes a powerful tool for a better characterization and classification of MS clinical profiles. Materials and Methods: Sixty-four MS patients [12 Clinical Isolated Syndrome (CIS), 24 Relapsing Remitting (RR), 24 Secondary Progressive (SP), and 17 Primary Progressive (PP)] along with 26 healthy controls (HC) underwent MR examination...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27813164/3d-accelerated-stack-of-spirals-acquisitions-and-reconstruction-of-arterial-spin-labeling-mri
#14
Yulin V Chang, Marta Vidorreta, Ze Wang, John A Detre
PURPOSE: The goal of this study was to develop a 3D acceleration and reconstruction method to improve image quality and resolution of background-suppressed arterial spin-labeled perfusion MRI. METHODS: Accelerated acquisition was implemented in all three k-space dimensions in a stack-of-spirals readout using variable density spirals and partition undersampling. A single 3D self-consistent parallel imaging (SPIRiT) kernel was calibrated and iteratively applied to reconstruct each imaging volume...
November 3, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27809861/do-the-risk-factors-for-type-2-diabetes-mellitus-vary-by-location-a-spatial-analysis-of-health-insurance-claims-in-northeastern-germany-using-kernel-density-estimation-and-geographically-weighted-regression
#15
Boris Kauhl, Jürgen Schweikart, Thomas Krafft, Andrea Keste, Marita Moskwyn
BACKGROUND: The provision of general practitioners (GPs) in Germany still relies mainly on the ratio of inhabitants to GPs at relatively large scales and barely accounts for an increased prevalence of chronic diseases among the elderly and socially underprivileged populations. Type 2 Diabetes Mellitus (T2DM) is one of the major cost-intensive diseases with high rates of potentially preventable complications. Provision of healthcare and access to preventive measures is necessary to reduce the burden of T2DM...
November 3, 2016: International Journal of Health Geographics
https://www.readbyqxmd.com/read/27783645/spatial-and-social-media-data-analytics-of-housing-prices-in-shenzhen-china
#16
Chao Wu, Xinyue Ye, Fu Ren, You Wan, Pengfei Ning, Qingyun Du
Housing is among the most pressing issues in urban China and has received considerable scholarly attention. Researchers have primarily concentrated on identifying the factors that influence residential property prices and how such mechanisms function. However, few studies have examined the potential factors that influence housing prices from a big data perspective. In this article, we use a big data perspective to determine the willingness of buyers to pay for various factors. The opinions and geographical preferences of individuals for places can be represented by visit frequencies given different motivations...
2016: PloS One
https://www.readbyqxmd.com/read/27782689/online-4d-ultrasound-guidance-for-real-time-motion-compensation-by-mlc-tracking
#17
Svenja Ipsen, Ralf Bruder, Rick O'Brien, Paul J Keall, Achim Schweikard, Per R Poulsen
PURPOSE: With the trend in radiotherapy moving toward dose escalation and hypofractionation, the need for highly accurate targeting increases. While MLC tracking is already being successfully used for motion compensation of moving targets in the prostate, current real-time target localization methods rely on repeated x-ray imaging and implanted fiducial markers or electromagnetic transponders rather than direct target visualization. In contrast, ultrasound imaging can yield volumetric data in real-time (3D + time = 4D) without ionizing radiation...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/27781214/giant-spin-orbit-effects-on-1-h-and-13-c-nmr-shifts-for-uranium-vi-complexes-revisited-role-of-the-exchange-correlation-response-kernel-bonding-analyses-and-new-predictions
#18
Anja H Greif, Peter Hrobárik, Jochen Autschbach, Martin Kaupp
Previous relativistic quantum-chemical predictions of unusually large (1)H and (13)C NMR chemical shifts for ligand atoms directly bonded to a diamagnetic uranium(vi) center (P. Hrobárik, V. Hrobáriková, A. H. Greif and M. Kaupp, Angew. Chem., Int. Ed., 2012, 51, 10884) have been revisited by two- and four-component relativistic density functional methods. In particular, the effect of the exchange-correlation response kernel, which had been missing in the previously used two-component version of the Amsterdam Density Functional program, has been examined...
October 26, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27772674/geolocalization-of-influenza-outbreak-within%C3%A2-an%C3%A2-acute-care-population-a-layered-surveillance-approach
#19
Vijay Christopher Kannan, Nicole Hodgson, Andrew Lau, Kate Goodin, Andrea Freyer Dugas, Frank LoVecchio
STUDY OBJECTIVE: We seek to use a novel layered-surveillance approach to localize influenza clusters within an acute care population. The first layer of this system is a syndromic surveillance screen to guide rapid polymerase chain reaction testing. The second layer is geolocalization and cluster analysis of these patients. We posit that any identified clusters could represent at-risk populations who could serve as high-yield targets for preventive medical interventions. METHODS: This was a prospective observational surveillance study...
November 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27762668/platynosomum-illiciens-trematoda-dicrocoeliidae-in-captive-black-tufted-marmoset-callithrix-penicillata-primates-cebidae-from-brazil-a-morphometric-analyses-with-taxonomic-comments-on-species-of-platynosomum-from-nonhuman-primates
#20
Hudson Alves Pinto, Vitor Luis Tenà Rio Mati, Diego Florencio Pujoni, Alan Lane de Melo
The trematodes belonging to the genus Platynosomum are biliary parasites of birds and mammals (domestic and wildlife) in tropical and subtropical areas of the globe. Despite several reports on platynosomosis in captive nonhuman primates, mainly in South America, the taxonomy of species of Platynosomum that infect these hosts remains confused, and it is not clear whether the species found in cats is the same that infects nonhuman primates. Because a detailed morphological study of Platynosomum from nonhuman primates is lacking, in this study we analyzed specimens of Platynosomum recovered from the biliary system of Callithrix penicillata kept in captivity in an animal facility...
October 20, 2016: Journal of Parasitology
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