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https://www.readbyqxmd.com/read/29158840/inorganic-kernel-reconstituted-lipoprotein-biomimetic-nanovehicles-enable-efficient-targeting-trojan-horse-delivery-of-stat3-decoy-oligonucleotide-for-overcoming-trail-resistance
#1
Kai Shi, Jianxiu Xue, Yan Fang, Hongshu Bi, Shan Gao, Dongjuan Yang, Anqi Lu, Yuai Li, Yao Chen, Liyuan Ke
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in a variety of tumor cells, but not most normal cells. Nevertheless, its therapeutic potential is limited due to the frequent occurrence of resistance in tumor cells, especially hepatocellular carcinoma cell lines. Therefore, we investigated the reversal effect of STAT3-decoy oligonucleotides (ODNs) on TRAIL resistance. Methods. Considering that the drawback of poor cellular permeability and rapid degradation in vivo limited ODNs' further clinical applications, we developed a biomimetic calcium phosphate-reconstituted low density lipoprotein nanovehicle (CaP@LDL) that would serve as a "Trojan horse" to carry STAT3-decoy ODNs into tumor cells and then regulate TRAIL-induced apoptosis...
2017: Theranostics
https://www.readbyqxmd.com/read/29158403/beating-the-curse-of-dimension-with-accurate-statistics-for-the-fokker-planck-equation-in-complex-turbulent-systems
#2
Nan Chen, Andrew J Majda
Solving the Fokker-Planck equation for high-dimensional complex dynamical systems is an important issue. Recently, the authors developed efficient statistically accurate algorithms for solving the Fokker-Planck equations associated with high-dimensional nonlinear turbulent dynamical systems with conditional Gaussian structures, which contain many strong non-Gaussian features such as intermittency and fat-tailed probability density functions (PDFs). The algorithms involve a hybrid strategy with a small number of samples [Formula: see text], where a conditional Gaussian mixture in a high-dimensional subspace via an extremely efficient parametric method is combined with a judicious Gaussian kernel density estimation in the remaining low-dimensional subspace...
November 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29135029/quantum-crystallography-a-perspective
#3
Lou Massa, Chérif F Matta
Extraction of the complete quantum mechanics from X-ray scattering data is the ultimate goal of quantum crystallography. This article delivers a perspective for that possibility. It is desirable to have a method for the conversion of X-ray diffraction data into an electron density that reflects the antisymmetry of an N-electron wave function. A formalism for this was developed early on for the determination of a constrained idempotent one-body density matrix. The formalism ensures pure-state N-representability in the single determinant sense...
November 14, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29127790/oil-and-gas-development-footprint-in-the-piceance-basin-western-colorado
#4
Cericia Martinez, Todd M Preston
Understanding long-term implications of energy development on ecosystem function requires establishing regional datasets to quantify past development and determine relationships to predict future development. The Piceance Basin in western Colorado has a history of energy production and development is expected to continue into the foreseeable future due to abundant natural gas resources. To facilitate analyses of regional energy development we digitized all well pads in the Colorado portion of the basin, determined the previous land cover of areas converted to well pads over three time periods (2002-2006, 2007-2011, and 2012-2016), and explored the relationship between number of wells per pad and pad area to model future development...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29118981/zika-virus-disease-microcephaly-and-guillain-barr%C3%A3-syndrome-in-colombia-epidemiological-situation-during-21%C3%A2-months-of-the-zika-virus-outbreak-2015-2017
#5
Nelson Méndez, Misael Oviedo-Pastrana, Salim Mattar, Isaac Caicedo-Castro, German Arrieta
Background: The Zika virus disease (ZVD) has had a huge impact on public health in Colombia for the numbers of people affected and the presentation of Guillain-Barre syndrome (GBS) and microcephaly cases associated to ZVD. Methods: A retrospective descriptive study was carried out, we analyze the epidemiological situation of ZVD and its association with microcephaly and GBS during a 21-month period, from October 2015 to June 2017. The variables studied were: (i) ZVD cases, (ii) ZVD cases in pregnant women, (iii) laboratory-confirmed ZVD in pregnant women, (iv) ZVD cases associated with microcephaly, (v) laboratory-confirmed ZVD associated with microcephaly, and (vi) ZVD associated to GBS cases...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29111709/casimir-polder-size-consistency-a-constraint-violated-by-some-dispersion-theories
#6
Tim Gould, Julien Toulouse, János G Ángyán, John F Dobson
A key goal in quantum chemistry methods, whether ab initio or otherwise, is to achieve size consistency. In this work we formulate the related idea of "Casimir-Polder size consistency" that manifests in long-range dispersion energetics. We show that local approximations in time-dependent density functional theory dispersion energy calculations violate the consistency condition because of incorrect treatment of highly nonlocal "xc kernel" physics, by up to 10% in our tests on closed-shell atoms.
November 10, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29108343/effect-of-amygdalus-scoparia-kernel-oil-consumption-on-lipid-profile-of-the-patients-with-dyslipidemia-a-randomized-open-label-controlled-clinical-trial
#7
Mohammad Javad Zibaeenezhad, Maryam Shahamat, Seyed Hamdollah Mosavat, Armin Attar, Ehsan Bahramali
Background: Amygdalus scoparia kernel (ASK) oil is traditionally used for Hyperlipidemia. Compared to olive oil, it has higher proportion of unsaturated to saturated fatty acid besides exhibiting higher index of oxidative stability. The lipid-lowering effects of ASK oil however, has not been investigated yet. This study is the first one to evaluate such effects in patients with dyslipidemia. Results: Serum triglyceride levels significantly decreased in the intervention compared to control group (24...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098170/interobserver-variability-in-tumor-contouring-affects-the-use-of-radiomics-to-predict-mutational-status
#8
Qiao Huang, Lin Lu, Laurent Dercle, Philip Lichtenstein, Yajun Li, Qian Yin, Min Zong, Lawrence Schwartz, Binsheng Zhao
Radiomic features characterize tumor imaging phenotype. Nonsmall cell lung cancer (NSCLC) tumors are known for their complexity in shape and wide range in density. We explored the effects of variable tumor contouring on the prediction of epidermal growth factor receptor (EGFR) mutation status by radiomics in NSCLC patients treated with a targeted therapy (Gefitinib). Forty-six early stage NSCLC patients (EGFR mutant:wildtype = 20:26) were included. Three experienced radiologists independently delineated the tumors using a semiautomated segmentation software on a noncontrast-enhanced baseline and three-week post-therapy CT scan images that were reconstructed using 1...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29078266/chemical-transferability-of-functional-groups-follows-from-the-nearsightedness-of-electronic-matter
#9
Stijn Fias, Farnaz Heidar-Zadeh, Paul Geerlings, Paul W Ayers
We establish the physical origins of chemical transferability from the perspective of the nearsightedness of electronic matter. To do this, we explicitly evaluate the response of electron density to a change in the system, at constant chemical potential, by computing the softness kernel, [Formula: see text] The softness kernel is nearsighted, indicating that under constant-chemical-potential conditions like dilute solutions changing the composition of the molecule at [Formula: see text] has only local effects and does not have any significant impact on the reactivity at positions [Formula: see text] far away from point [Formula: see text] This locality principle elucidates the transferability of functional groups in chemistry...
October 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29075445/how-far-do-adult-turtles-move-home-range-and-dispersal-of-kinosternon-integrum
#10
Ailed Pérez-Pérez, Ana Esthela López-Moreno, Orlando Suárez-Rodríguez, Justin Lloyd Rheubert, Oswaldo Hernández-Gallegos
We describe the home range and movements of a population of Kinosternon integrum in Tonatico, Estado de México, México, over 3.5 years (during rainy and dry season months) using radiotelemetry in 37 adult turtles. The results showed that the home range of K. integrum was 0.151 ± 0.051 ha using 50% kernel density estimator (KDE), and 0.657 ± 0.214 ha using 95% KDE; the home range did not vary between sexes. Kinosternon integrum showed low distances traveled 51.44 ± 4.50 m, where 87.3% (n = 373) of movements were <100 m...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29065186/environmental-risk-of-leptospirosis-infections-in-the-netherlands-spatial-modelling-of-environmental-risk-factors-of-leptospirosis-in-the-netherlands
#11
Ente J J Rood, Marga G A Goris, Roan Pijnacker, Mirjam I Bakker, Rudy A Hartskeerl
Leptospirosis is a globally emerging zoonotic disease, associated with various climatic, biotic and abiotic factors. Mapping and quantifying geographical variations in the occurrence of leptospirosis and the surrounding environment offer innovative methods to study disease transmission and to identify associations between the disease and the environment. This study aims to investigate geographic variations in leptospirosis incidence in the Netherlands and to identify associations with environmental factors driving the emergence of the disease...
2017: PloS One
https://www.readbyqxmd.com/read/29064109/single-determinant-n-representability-and-the-kernel-energy-method-applied-to-water-clusters
#12
Walter Polkosnik, Lou Massa
The Kernel energy method (KEM) is a quantum chemical calculation method that has been shown to provide accurate energies for large molecules. KEM performs calculations on subsets of a molecule (called kernels) and so the computational difficulty of KEM calculations scales more softly than full molecule methods. Although KEM provides accurate energies those energies are not required to satisfy the variational theorem. In this article, KEM is extended to provide a full molecule single-determinant N-representable one-body density matrix...
October 24, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29060640/simulations-of-high-density-surface-electromyograms-in-dynamic-muscle-contractions
#13
V Glaser, D Farina, A Holobar
We describe the extension of pre-existing cylindrical volume conductor model to synthetic high-density surface electromyograms (hdEMG), simulated during dynamic contractions of fusiform skeletal muscles. Its modular structure comprises two main parts. First, dynamic changes of motor unit action potentials (MUAPs) during 36 discrete steps of muscle shortening are simulated. Second, the increase in depth of simulated motor units (MUs) due to shortening and thickening of muscle fibers is simulated. MU firing patterns are generated with the model proposed by Fuglevand et al...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29054559/the-influence-of-reconstruction-kernel-on-bone-mineral-and-strength-estimates-using-quantitative-computed-tomography-and-finite-element-analysis
#14
Andrew S Michalski, W Brent Edwards, Steven K Boyd
Quantitative computed tomography has been posed as an alternative imaging modality to investigate osteoporosis. We examined the influence of computed tomography convolution back-projection reconstruction kernels on the analysis of bone quantity and estimated mechanical properties in the proximal femur. Eighteen computed tomography scans of the proximal femur were reconstructed using both a standard smoothing reconstruction kernel and a bone-sharpening reconstruction kernel. Following phantom-based density calibration, we calculated typical bone quantity outcomes of integral volumetric bone mineral density, bone volume, and bone mineral content...
October 17, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29040200/geospatial-mapping-can-be-used-to-identify-geographic-areas-and-social-factors-associated-with-intentional-injury-as-targets-for-prevention-efforts-distinct-to-a-given-community
#15
C H Lasecki, F C Mujica, S Stutsman, A Y Williams, L Ding, J D Simmons, S B Brevard
BACKGROUND: Geographic information systems (GIS) have proven effective in studying intentional injury in various communities; however, GIS is not implemented widely for use by level I trauma centers in understanding patient populations. Our study of intentional injury combines the capabilities of GIS with a level I trauma center registry to determine the spatial distribution of victims and correlated socioeconomic factors. METHODS: 1,099 out of 3,109 total incidents of intentional trauma in the trauma registry from 2005-2015 had sufficient street address information to be mapped in GIS...
October 16, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28989320/nonparametric-methods-for-doubly-robust-estimation-of-continuous-treatment-effects
#16
Edward H Kennedy, Zongming Ma, Matthew D McHugh, Dylan S Small
Continuous treatments (e.g., doses) arise often in practice, but many available causal effect estimators are limited by either requiring parametric models for the effect curve, or by not allowing doubly robust covariate adjustment. We develop a novel kernel smoothing approach that requires only mild smoothness assumptions on the effect curve, and still allows for misspecification of either the treatment density or outcome regression. We derive asymptotic properties and give a procedure for data-driven bandwidth selection...
September 2017: Journal of the Royal Statistical Society. Series B, Statistical Methodology
https://www.readbyqxmd.com/read/28988199/spatial-distribution-of-pedestrian-motor-vehicle-collisions-before-and-after-pedestrian-countdown-signal-installation-in-toronto-canada
#17
Linda Rothman, Marie-Soleil Cloutier, Alison K Macpherson, Sarah A Richmond, Andrew William Howard
BACKGROUND: Pedestrian countdown signals (PCS) have been installed in many cities over the last 15 years. Few studies have evaluated the effectiveness of PCS on pedestrian motor vehicle collisions (PMVC). This exploratory study compared the spatial patterns of collisions pre and post PCS installation at PCS intersections and intersections or roadways without PCS in Toronto, and examined differences by age. METHODS: PCS were installed at the majority of Toronto intersections from 2007 to 2009...
October 7, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28987104/excitation-energies-from-particle-particle-random-phase-approximation-with-accurate-optimized-effective-potentials
#18
Ye Jin, Yang Yang, Du Zhang, Degao Peng, Weitao Yang
The optimized effective potential (OEP) that gives accurate Kohn-Sham (KS) orbitals and orbital energies can be obtained from a given reference electron density. These OEP-KS orbitals and orbital energies are used here for calculating electronic excited states with the particle-particle random phase approximation (pp-RPA). Our calculations allow the examination of pp-RPA excitation energies with the exact KS density functional theory (DFT). Various input densities are investigated. Specifically, the excitation energies using the OEP with the electron densities from the coupled-cluster singles and doubles method display the lowest mean absolute error from the reference data for the low-lying excited states...
October 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28958551/density-separation-as-a-strategy-to-reduce-the-enzyme-load-of-preharvest-sprouted-wheat-and-enhance-its-bread-making-quality
#19
Heleen Olaerts, Yamina De Bondt, Christophe M Courtin
As preharvest sprouting of wheat impairs its use in food applications, postharvest solutions for this problem are required. Due to the high kernel to kernel variability in enzyme activity in a batch of sprouted wheat, the potential of eliminating severely sprouted kernels based on density differences in NaCl solutions was evaluated. Compared to higher density kernels, lower density kernels displayed higher α-amylase, endoxylanase, and peptidase activities as well as signs of (incipient) protein, β-glucan and arabinoxylan breakdown...
February 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28947920/prediction-model-based-kernel-density-estimation-when-group-membership-is-subject-to-missing
#20
Hua He, Wenjuan Wang, Wan Tang
The density function is a fundamental concept in data analysis. When a population consists of heterogeneous subjects, it's often of great interest to estimate the density functions of the subpopulations. Nonparametric methods such as kernel smoothing estimates may be applied to each subpopulation to estimate the density functions if there are no missing values. In situations where the membership for a subpopulation is missing, kernel smoothing estimates using only subjects with membership available are valid only under missing complete at random (MCAR)...
July 2017: Advances in Statistical Analysis: AStA: a Journal of the German Statistical Society
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