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https://www.readbyqxmd.com/read/28527113/mutant-p53-promotes-cell-spreading-and-migration-via-arhgap44
#1
Jinjin Xu, Jian Jiao, Wei Xu, Lei Ji, Dongjie Jiang, Shaofang Xie, Syeda Kubra, Xiaotao Li, Junjiang Fu, Jianru Xiao, Bianhong Zhang
The tumor suppressor p53 protein is either lost or mutated in about half of all human cancers. Loss of p53 function is well known to influence cell spreading, migration and invasion. While expression of mutant p53 is not equivalent to p53 loss, mutant p53 can acquire new functions to drive cell spreading and migration via different mechanisms. In our study, we found that mutant p53 significantly increased cell spreading and migration when comparing with p53-null cells. RNA-Seq analysis suggested that Rho GTPase activating protein 44 (ARHGAP44) is a new target of mutant p53, which suppressed ARHGAP44 transcription...
May 16, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28526753/altered-feto-placental-vascularization-feto-placental-malperfusion-and-fetal-growth-restriction-in-mice-with-egfl7-loss-of-function
#2
Lauretta A Lacko, Romulo Hurtado, Samantha Hinds, Michael G Poulos, Jason M Butler, Heidi Stuhlmann
EGFL7 is a secreted, angiogenic factor produced by embryonic endothelial cells. To understand its role in placental development, we established a novel Egfl7 knockout mouse. The mutant mice have gross defects in chorioallantoic branching morphogenesis and placental vascular patterning. Microangiography and 3D imaging revealed patchy perfusion of Egfl7(-/-) placentas marked by impeded blood conductance through sites of narrowed vessels. Consistent with poor feto-placental perfusion, Egfl7 knockout resulted in reduced placental weight and fetal growth restriction...
May 19, 2017: Development
https://www.readbyqxmd.com/read/28526725/phylogeography-and-genetic-structure-of-endemic-acmispon-argophyllus-and-a-dendroideus-fabaceae-across-the-california-channel-islands
#3
Lisa E Wallace, Gregory L Wheeler, Mitchell E McGlaughlin, Gerald Bresowar, Kaius Helenurm
PREMISE OF THE STUDY: Taxa inhabiting the California Channel Islands exhibit variation in their degree of isolation, but few studies have considered patterns across the entire archipelago. We studied phylogeography of insular Acmispon argophyllus and A. dendroideus to determine whether infraspecific taxa are genetically divergent and to elucidate patterns of diversification across these islands. METHODS: DNA sequences were collected from nuclear (ADH) and plastid genomes (rpL16, ndhA, psbD-trnT) from >450 samples on the Channel Islands and California...
May 19, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28526242/factors-predicting-complications-after-sacral-neuromodulation-in-children
#4
Molly E Fuchs, Peter L Lu, Stephanie J Vyrostek, Steven Teich, Seth A Alpert
OBJECTIVES: To identify if any pre-operative variable are associated with post-operative complications after pediatric sacral neuromodulation (SNM). METHODS: A review of all patients undergoing SNM with an implantable pulse generator at our institution was performed. Post-operative infection, lead migration, lead breakage and need for reoperation were recorded in a prospective database. We collected demographic information and indication for the procedure. We defined indication for procedure as either primarily bowel, or primarily bladder symptoms...
May 16, 2017: Urology
https://www.readbyqxmd.com/read/28525980/the-distribution-of-mitochondrial-dna-haplogroup-h-in-southern-iberia-indicates-ancient-human-genetic-exchanges-along-the-western-edge-of-the-mediterranean
#5
Candela L Hernández, Jean M Dugoujon, Andrea Novelletto, Juan N Rodríguez, Pedro Cuesta, Rosario Calderón
BACKGROUND: The structure of haplogroup H reveals significant differences between the western and eastern edges of the Mediterranean, as well as between the northern and southern regions. Human populations along the westernmost Mediterranean coasts, which were settled by individuals from two continents separated by a relatively narrow body of water, show the highest frequencies of mitochondrial haplogroup H. These characteristics permit the analysis of ancient migrations between both shores, which may have occurred via primitive sea crafts and early seafaring...
May 19, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28525898/ginsenoside-rg3-inhibits-the-senescence-of-prostate-stromal-cells-through-down-regulation-of-interleukin-8-expression
#6
Yanfei Peng, Ran Zhang, Lingfei Kong, Yongmei Shen, Da Xu, Fang Zheng, Jianwei Liu, Qian Wu, Bona Jia, Ju Zhang
Senescent stromal cells support the development of prostate cancer and are considered potential therapeutic targets. This research evaluated the regulatory effects of ginsenoside Rg3 on the senescence of prostatic stromal cells pre-incubated in medium supplemented with 0.5% fetal bovine serum. The results revealed that ginsenoside Rg3 decreased the number of stromal cells positively stained with a senescent cell marker (senescence-associated β-galactosidase). Ginsenoside Rg3 also increased the viability of stromal cells and promoted cell cycle transition from G0/G1 to S phase, as well as inhibited the carcinoma-associated fibroblast-like phenotype in prostate stromal cells, through the up-regulation of smooth muscle cell markers SM22 and smooth muscle myosin heavy chain...
May 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28525724/interaction-between-mir-572-and-ppp2r2c-and-their-effects-on-proliferation-migration-and-invasion-of-nasopharyngeal-carcinoma-npc-cells
#7
Lei Yan, Kerui Cai, Jun Liang, Haifeng Liu, Yang Liu, Jinqiu Gui
We investigated the regulation of miR-572 on PPP2R2C and studied their effects on proliferation, migration as well as invasion of nasopharyngeal carcinoma (NPC) cells. NPC tissues and normal tissues were collected, and the expressions of miR-572 and PPP2R2C were detected by RT-PCR. And Western blot was applied to detect the expression of PPP2R2C protein. The target relationship between miR-572 and PPP2R2C was confirmed by dual luciferase reporter gene assay. MTT assay and flow cytometry was applied to investigate the viability and apoptosis of NPC cells...
May 19, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28525663/management-of-male-and-female-neurogenic-stress-urinary-incontinence-in-spinal-cord-injured-sci-patients-using-adjustable-continence-therapy
#8
Enrico Ammirati, Alberto Manassero, Alessandro Giammò, Roberto Carone
INTRODUCTION: Artificial urinary sphincter (AUS) is an option for the treatment of neurogenic stress urinary incontinence (nSUI), but complications and re-operation rates are high, and there is no clear indication from guidelines (1). The aim of our study is to evaluate the effectiveness of a less invasive continence device in neurogenic population: Adjustable Continence Therapy ProACT/ACT®. METHODS: We retrospectively includedpatients with spinal cord injuries in this study, complaining of nSUI and treated at our Institution with Pro-ACT/ACT® implantation...
May 16, 2017: Urologia
https://www.readbyqxmd.com/read/28524717/first-molecular-evidence-of-mus-musculus-bactrianus-in-nepal-inferred-from-the-mitochondrial-dna-cytochrome-b-gene-sequences
#9
Pradeep Adhikari, Sang-Hyun Han, Yoo-Kyung Kim, Tae-Wook Kim, Tej Bahadur Thapa, Naresh Subedi, Prabhat Adhikari, Hong-Shik Oh
To identify the house mice collected in Pokhara and Lumbini of Nepal at the subspecies level, morphological and molecular analyses were carried out. Morphologically, two populations collected in Pokhara and Lumbini were distinguished by fur colour, but there was no significant difference in external measurements (p > .05). The phylogenetic analysis results revealed that the haplotypes sequences of mitochondrial DNA (mtDNA) Cytochrome B (CytB) gene distinguished into two distinct clades on a phylogenetic tree representing two subspecies, Mus musculus bactrianus and M...
May 19, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28523467/elevated-expression-of-cst1-promotes-breast-cancer-progression-and-predicts-a-poor-prognosis
#10
Da-Nian Dai, Yan Li, Bo Chen, Yong Du, Shi-Bing Li, Shi-Xun Lu, Zhi-Ping Zhao, Ai-Jun Zhou, Ning Xue, Tian-Liang Xia, Mu-Sheng Zeng, Qian Zhong, Wei-Dong Wei
Cystatin SN (CST1) belongs to the type 2 cystatin (CST) superfamily, which restricts the proteolytic activities of cysteine proteases. CST1 has been recently considered to be involved in the development of several human cancers. However, the prognostic significance and function of CST1 in breast cancer remains unknown. In the current study, we found that CST1 was generally upregulated in breast cancer at both mRNA and protein level. Furthermore, overall survival (OS) and disease-free survival (DFS) in the low CST1 expression subgroup were significantly superior to the high CST1 expression subgroup (OS, p < 0...
May 18, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28515724/an-analysis-of-trafficking-receptors-shows-that-cd44-and-p-selectin-glycoprotein-ligand-1-collectively-control-the-migration-of-activated-human-t-cells
#11
Amal J Ali, Ayman F Abuelela, Jasmeen S Merzaban
Selectins guide the traffic of activated T-cells through the blood stream by mediating their tethering and rolling onto inflamed endothelium, in this way acting as beacons to help navigate them to sites of inflammation. Here, we present a comprehensive analysis of E-selectin ligands expressed on activated human T-cells. We identified several novel glycoproteins that function as E-selectin ligands. Specifically, we compared the role of P-selectin glycoprotein ligand-1 (PSGL-1) and CD43, known E-selectin ligands, to CD44, a ligand that has not previously been characterized as an E-selectin ligand on activated human T-cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28515356/licensing-delineates-helper-and-effector-nk-cell-subsets-during-viral-infection
#12
Anthony E Zamora, Ethan G Aguilar, Can M Sungur, Lam T Khuat, Cordelia Dunai, G Raymond Lochhead, Juan Du, Claire Pomeroy, Bruce R Blazar, Dan L Longo, Jeffrey M Venstrom, Nicole Baumgarth, William J Murphy
Natural killer (NK) cells can be divided into phenotypic subsets based on expression of receptors that bind self-MHC-I molecules, a concept termed licensing or education. Here we show NK cell subsets with different migratory, effector, and immunoregulatory functions in dendritic cell and antigen (ag)-specific CD8+ T cell responses during influenza and murine cytomegalovirus infections. Shortly after infection, unlicensed NK cells localized in draining lymph nodes and produced GM-CSF, which correlated with the expansion and activation of dendritic cells, and resulted in greater and sustained ag-specific T cell responses...
May 18, 2017: JCI Insight
https://www.readbyqxmd.com/read/28515195/cohort-profile-internal-migration-in-sub-saharan-africa-the-migration-and-health-in-malawi-mhm-study
#13
Philip Anglewicz, Mark VanLandingham, Lucinda Manda-Taylor, Hans-Peter Kohler
PURPOSE: The Migration and Health in Malawi (MHM) study focuses on a key challenge in migration research: although it has long been established that migration and health are closely linked, identifying the effect of migration on various health outcomes is complicated by methodological challenges. The MHM study uses a longitudinal panel premigration and postmigration study design (with a non-migrant comparison group) to measure and/or control for important characteristics that affect both migration and health outcomes...
May 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28512436/transition-to-kindergarten-negative-associations-between-the-emotional-availability-in-mother-child-relationships-and-elevated-cortisol-levels-in-children-with-an-immigrant-background
#14
Constanze Rickmeyer, Judith Lebiger-Vogel, Marianne Leuzinger-Bohleber
Background: The transition to child care is a challenging time in a child's life and leads to elevated levels of cortisol. These elevations may be influenced by the quality of the mother-child relationship. However, remarkably little is known about cortisol production in response to the beginning of child care among children-at-risk such as children with an immigrant background. However, attending kindergarten or any other child day-care institution can for example have a compensating effect on potential language deficits thus improving the educational opportunities of these children...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28512143/diverse-roles-of-guanine-nucleotide-exchange-factors-in-regulating-collective-cell-migration
#15
Assaf Zaritsky, Yun-Yu Tseng, M Angeles Rabadán, Shefali Krishna, Michael Overholtzer, Gaudenz Danuser, Alan Hall
Efficient collective migration depends on a balance between contractility and cytoskeletal rearrangements, adhesion, and mechanical cell-cell communication, all controlled by GTPases of the RHO family. By comprehensive screening of guanine nucleotide exchange factors (GEFs) in human bronchial epithelial cell monolayers, we identified GEFs that are required for collective migration at large, such as SOS1 and β-PIX, and RHOA GEFs that are implicated in intercellular communication. Down-regulation of the latter GEFs differentially enhanced front-to-back propagation of guidance cues through the monolayer and was mirrored by down-regulation of RHOA expression and myosin II activity...
May 16, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28509381/topography-guided-control-of-local-migratory-behaviors-and-protein-expression-of-cancer-cells
#16
Jung-Youn Shin, Hong Nam Kim, Suk Ho Bhang, Jeong-Kee Yoon, Kahp-Yang Suh, Noo Li Jeon, Byung-Soo Kim
In vivo cancer cell migration and invasion are directed by biophysical guidance mechanisms such as pre-existing microtracks and basement membrane extracellular matrices. Here, this paper reports the correlation of the local migratory behavior of cancer cells and the biochemical signal expression using the topography that can guide or inhibit cell behaviors. To this end, the local apparent migration and the protein expression level are investigated with respect to the topographical feature size (flat, nanoline, and microline) and orientation (microline, microconcentric, and microradial) with the collectively migrating (A431) and individually migrating (MDA-MB-231 and U-87-MG) cancer cells...
May 16, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28507311/disruption-of-shh-signaling-cascade-by-sbe-attenuates-lung-cancer-progression-and-sensitizes-ddp-treatment
#17
Jing Du, Weiwei Chen, Lijuan Yang, Juanjuan Dai, Jiwei Guo, Yan Wu, Kaikai Gong, Jian Zhang, Ning Yu, Zhen Xie, Sichuan Xi
Deregulated Sonic Hedgehog (SHH) pathway facilitates the initiation, progression, and metastasis of Non-small cell lung cancer (NSCLC), confers drug resistance and renders a therapeutic interference option to lung cancer patients with poor prognosis. In this study, we screened and evaluated the specificity of a Chinese herb Scutellariabarbata D. Don extraction (SBE) in repressing SHH signaling pathway to block NSCLC progression. Our study confirmed that aberrant activation of the SHH signal pathway conferred more proliferative and invasive phenotypes to human lung cancer cells...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28506857/foxk2-regulted-by-mir-1271-5p-promotes-cell-growth-and-indicates-unfavorable-prognosis-in-hepatocellular-carcinoma
#18
Mei-Fang Lin, Yu-Feng Yang, Zhen-Peng Peng, Mei-Fang Zhang, Jin-Yu Liang, Wei Chen, Xu-Hui Liu, Yan-Ling Zheng
The forkhead transcription factor FOXK2 has been implicated in the progression of human cancers, but its role and clinical significance in hepatocellular carcinoma (HCC) have not been explored. Here we showed that FOXK2 expression was increased and associated with tumor size, TNM stage and vascular invasion. High FOXK2 expression was correlated with poor overall and disease-free survival in two independent cohorts consisting of 864 patients with HCC. The prognostic value of FOXK2 was validated by stratified survival analyses in subgroups difined by factors contributing to worse survival...
May 12, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28505274/migration-analysis-of-sogatella-furcifera-hemiptera-delphacidae-in-the-northeastern-hunan-province-in-june
#19
Mingyong Ma, Yan Wu, Zhaopu Peng, Xin Zhao, Yi Zhang, Guoan Liao, Baoping Zhai
The Sogatella furcifera (Horváth) is a notorious and destructive insect pest, targeting >4 million hectares of rice cultivated in the Hunan Province. To understand the immigration dynamics, we collected S. furcifera light trap catches from 2006 to 2012 at Niangxiang, Linxiang, and Hanshou. We conducted a migration analysis to estimate the immigration source for the northeastern Hunan Province in June. Moreover, we dissected the ovaries of S. furcifera to classify population characteristics. We found that the first appearance of S...
May 13, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28504918/sheep-placenta-cotyledons-a-noninvasive-source-of-ovine-mesenchymal-stem-cells
#20
Iris Ribitsch, Souyet Chang-Rodriguez, Monika Egerbacher, Simone Gabner, Sinan Gueltekin, Johann Huber, Therese Schuster, Florien Jenner
Sheep are one of the most frequently used large animal models in stem cell research. However, minimal invasive or noninvasive sources of mesenchymal stem cells (MSCs) in sheep are scarce. In the light of the principles of the 3Rs (reduce, refine, replace), it would therefore be desirable to identify a minimally invasive or noninvasive ovine MSC source. In humans, the chorionic villi of the placenta, which can be noninvasively harvested as part of the afterbirth, have been identified as a rich source of MSCs...
May 2017: Tissue Engineering. Part C, Methods
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