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https://www.readbyqxmd.com/read/28748333/evaluation-of-motor-skills-in-children-with-rubinstein-taybi-syndrome
#1
Jean René Cazalets, Emma Bestaven, Emilie Doat, Marie Pierre Baudier, Cécile Gallot, Anouck Amestoy, Manuel Bouvard, Etienne Guillaud, Isabelle Guillain, Emelyne Grech, Julien Van-Gils, Patricia Fergelot, Sonia Fraisse, Emmanuelle Taupiac, Benoit Arveiler, Didier Lacombe
Rubinstein-Taybi syndrome (RTS) is a rare genetic disease that associates intellectual disability with somatic characteristics. We have conducted a study of the overall motor abilities of RTS participants. Static postural performance as well as gait parameters were somewhat decreased, although not significantly compared to typically developing (TD) participants. In contrast, the motor skills requiring a high level of visuomotor coordination were considerably degraded in RTS participants compared to TD participants...
July 26, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28747885/effects-of-aging-stereotype-threat-on-working-self-concepts-an-event-related-potentials-approach
#2
Baoshan Zhang, Yao Lin, Qianyun Gao, Magdalena Zawisza, Qian Kang, Xuhai Chen
Although the influence of stereotype threat (ST) on working self-concepts has been highlighted in recent years, its neural underpinnings are unclear. Notably, the aging ST, which largely influences older adults' cognitive ability, mental and physical health, did not receive much attention. In order to investigate these issues, electroencephalogram (EEG) data were obtained from older adults during a modified Stroop task using neutral words, positive and negative self-concept words in aging ST vs. neutral control conditions...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28744687/lin28a-a-sensitive-immunohistochemical-marker-for-embryonal-tumor-with-multilayered-rosettes-etmr-is-also-positive-in-a-subset-of-atypical-teratoid-rhabdoid-tumor-at-rt
#3
Shilpa Rao, R T Rajeswarie, T Chickabasaviah Yasha, Bevinahalli N Nandeesh, Arimappamagan Arivazhagan, Vani Santosh
INTRODUCTION: CNS embryonal tumors comprise a group of highly malignant neoplasms with a wide spectrum of histomorphological entities that includes Medulloblastoma (MB), Atypical Teratoid/Rhabdoid Tumor (AT/RT), Neuroblastoma (NB), Ganglioneuroblastoma (GNB), Embryonal Tumor with Multilayered Rosettes (ETMR), and the embryonal tumor-Not Otherwise Specified (NOS). The entity ETMR includes previously described histopathologic patterns-Embryonal Tumor with Abundant Neuropil and True Rosettes (ETANTR), Ependymoblastoma (EBL), and Medulloepithelioma (MEPL)...
July 25, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28740923/a-comparison-of-interfraction-setup-error-patient-comfort-and-therapist-acceptance-for-2-different-prostate-radiation-therapy-immobilization-devices
#4
Eric Pei Ping Pang, Kellie Knight, Marilyn Baird, Joshua Ming Quan Loh, Adelene Hwee San Boo, Jeffrey Kit Loong Tuan
PURPOSE: Our purpose was to investigate interfraction setup error of the immobilization device required to implement transperineal ultrasound compared with the current, standard immobilization device. Patient comfort and radiation therapist (RT) satisfaction were also assessed. METHODS AND MATERIALS: Cone beam computed tomography images were acquired before 4069 fractions from 111 patients (control group, n = 56; intervention group, n = 55) were analyzed. The intervention group was immobilized using the Clarity Immobilization System (CIS), comprising a knee rest with autoscan probe kit and transperineal ultrasound probe (n = 55), and control group using a leg immobilizer (LI) (n = 56)...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28739442/no-effect-of-hippocampal-lesions-on-stimulus-response-bindings
#5
Richard N Henson, Aidan J Horner, Andrea Greve, Elisa Cooper, Mariella Gregori, Jon S Simons, Sharon Erzinçlioğlu, Georgina Browne, Narinder Kapur
The hippocampus is believed to be important for rapid learning of arbitrary stimulus-response contingencies, or S-R bindings. In support of this, Schnyer et al., 2006 (Experiment 2) measured priming of reaction times (RTs) to categorise visual objects, and found that patients with medial temporal lobe damage, unlike healthy controls, failed to show evidence of reduced priming when response contingencies were reversed between initial and repeated categorisation of objects (a signature of S-R bindings). We ran a similar though extended object classification task on 6 patients who appear to have selective hippocampal lesions, together with 24 age-matched controls...
July 21, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28739240/evaluation-of-situation-background-assessment-recommendation-tool-during-neonatal-and-pediatric-interfacility-transport
#6
Diane Wilson, Anuradha Kochar, Andrew Whyte-Lewis, Hilary Whyte, Kyong-Soon Lee
OBJECTIVE: We aimed to determine if the implementation of Situation, Background, Assessment, Recommendation (SBAR) training improved the quality of real-life telephone communication. We evaluated interfacility neonatal and pediatric transports performed by registered nurses, respiratory therapists, and physicians (MDs). METHODS: This was a quality improvement study performed to evaluate telephone communication before and after SBAR training. Training consisted of lectures, review of audio files, and simulated role-playing...
July 2017: Air Medical Journal
https://www.readbyqxmd.com/read/28732020/setting-strategy-of-delay-optimization-oriented-smac-contention-window-size
#7
Yuan Rao, Cheng Deng, Jun Su, Yan Qiao, Jun Zhu, Ru-Chuan Wang
Some frame components, such as SYNC (frame synchronization) and RTS/CTS (Ready to Send/Clear to Send), are not taken into consideration when the traditional setting strategies conduct the optimization of SMAC (Sensor MAC) contention window size. This paper proposes mathematical models that allow the analysis of data packets forwarding delay within one SMAC virtual cluster. Simulation results in OMNeT++ show good agreements with the proposed mathematical models, validating the models' correctness. The curve analyses of the models confirm the existence of delay-optimization-oriented contention window size that is closely related to the number of simultaneously contending nodes...
2017: PloS One
https://www.readbyqxmd.com/read/28731898/steady-progress-toward-a-malaria-vaccine
#8
Kirsten E Lyke
PURPOSE OF REVIEW: Great progress has been made in reducing malaria morbidity and mortality, yet the parasite continues to cause a startling 200 million infections and 500 000 deaths annually. Malaria vaccine development is pushing new boundaries by steady advancement toward a licensed product. RECENT FINDINGS: Despite 50 years of research, the complexity of Plasmoidum falciparum confounds all attempts to eradicate the organism. This very complexity has pushed the boundaries of vaccine development to new heights, yet it remains to be seen if an affordable vaccine can provide durable and high-level protection...
July 20, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28731288/radiation-therapists-perspectives-on-participating-in-research
#9
Georgia K B Halkett, Melissa Berg, Martin A Ebert, David Cutt, Michael Davis, Desley Hegney, Michael House, Michelle Judson, Rachel Kearvell, Michele Krawiec, Leanne Lester, Sharon Maresse, Peter McLoone, Jan McKay
INTRODUCTION: The objectives of this research were to: (1) determine the extent of Australian radiation therapists (RTs) research participation; (2) evaluate the impact of research involvement on career perceptions (3) explore which research topics require investigation and (4) identify benefits and barriers to research participation. METHODS: This study used mixed methods to collect qualitative and quantitative data using an online survey from a larger workforce study of RTs and radiation oncology medical physicists...
July 21, 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/28728622/psychomotor-vigilance-test-and-its-association-with-daytime-sleepiness-and-inflammation-in-sleep-apnea-clinical-implications
#10
Yun Li, Alexandros Vgontzas, Ilia Kritikou, Julio Fernandez-Mendoza, Maria Basta, Slobodanka Pejovic, Jordan Gaines, Edward O Bixler
STUDY OBJECTIVES: Excessive daytime sleepiness (EDS) is a key symptom of obstructive sleep apnea (OSA). The Psychomotor Vigilance Task (PVT) has been suggested as an objective easy-to-use, inexpensive alternative to the Multiple Sleep Latency Test (MSLT) to measure EDS. In patients with OSA, physiological sleepiness, but not subjective EDS (Epworth Sleepiness Scale [ESS]), has been associated with increased levels of the sleep- inducing proinflammatory cytokine interleukin-6 (IL-6). The goal of this study was to assess the association of PVT with objectively measured sleepiness (MSLT) and subjectively measured sleepiness (ESS) and IL-6 levels in patients with OSA...
July 14, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28718301/web-addiction-in-the-brain-cortical-oscillations-autonomic-activity-and-behavioral-measures
#11
Michela Balconi, Salvatore Campanella, Roberta Finocchiaro
Background and aims Internet addiction (IA) was recently defined as a disorder tagging both the impulse control and the reward systems. Specifically, inhibitory deficits and reward bias were considered highly relevant in IA. This research aims to examine the electrophysiological correlates and autonomic activity [skin conductance response (SCR) and heart rate] in two groups of young subjects (N = 25), with high or low IA profile [tested by the Internet Addiction Test (IAT)], with specific reference to gambling behavior...
July 18, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28716210/exploring-injury-severity-measures-and-in-hospital-mortality-a-multi-hospital-study-in-kenya
#12
Yuen W Hung, Huan He, Amber Mehmood, Isaac Botchey, Hassan Saidi, Adnan A Hyder, Abdulgafoor M Bachani
INTRODUCTION: Low- and middle-income countries (LMICs) have a disproportionately high burden of injuries. Most injury severity measures were developed in high-income settings and there have been limited studies on their application and validity in low-resource settings. In this study, we compared the performance of seven injury severity measures: estimated Injury Severity Score (eISS), Glasgow Coma Score (GCS), Mechanism, GCS, Age, Pressure score (MGAP), GCS, Age, Pressure score (GAP), Revised Trauma Score (RTS), Trauma and Injury Severity Score (TRISS) and Kampala Trauma Score (KTS), in predicting in-hospital mortality in a multi-hospital cohort of adult patients in Kenya...
July 8, 2017: Injury
https://www.readbyqxmd.com/read/28714710/a-relative-bilingual-advantage-in-switching-with-preparation-nuanced-explorations-of-the-proposed-association-between-bilingualism-and-task-switching
#13
Alena Stasenko, Georg E Matt, Tamar H Gollan
Bilingual language switching may increase general switching efficiency, but the evidence on this question is mixed. We hypothesized that group differences in switching might be stronger at a long cue-target interval (CTI), which may better tap general switching abilities (Yehene & Meiran, 2007). Eighty Spanish-English bilinguals and 80 monolinguals completed a color-shape switching task, and an analogous language-switching task, varying CTI (short vs. long) in both tasks. With longer preparation time (long CTI), bilinguals exhibited significantly smaller task-switching costs than monolinguals, but only in the first half of trials...
July 17, 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/28713234/leftward-deviation-and-asymmetric-speed-of-egocentric-judgment-between-left-and-right-visual-fields
#14
Ying Zhou, Bing Li, Gang Wang, Mingsha Zhang, Yujun Pan
The egocentric reference frame is essential for body orientation and spatial localization of external objects. Recent neuroimaging and lesion studies have revealed that the right hemisphere of humans may play a more dominant role in processing egocentric information than the left hemisphere. However, previous studies of egocentric discrimination mainly focused on assessing the accuracy of egocentric judgment, leaving its timing unexplored. In addition, most previous studies never monitored the subjects' eye position during the experiments, so the influence of eye position on egocentric judgment could not be excluded...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28708027/do-valenced-odors-and-trait-body-odor-disgust-affect-evaluation-of-emotion-in-dynamic-faces
#15
Elmeri Syrjänen, Marco Tullio Liuzza, Håkan Fischer, Jonas K Olofsson
Disgust is a core emotion evolved to detect and avoid the ingestion of poisonous food as well as the contact with pathogens and other harmful agents. Previous research has shown that multisensory presentation of olfactory and visual information may strengthen the processing of disgust-relevant information. However, it is not known whether these findings extend to dynamic facial stimuli that changes from neutral to emotionally expressive, or if individual differences in trait body odor disgust may influence the processing of disgust-related information...
January 1, 2017: Perception
https://www.readbyqxmd.com/read/28707215/disentangling-perceptual-and-psycholinguistic-factors-in-syntactic-processing-tone-monitoring-via-erps
#16
David J Lobina, Josep Demestre, José E García-Albea
Franco, Gaillard, Cleeremans, and Destrebecqz (Behavior Research Methods, 47, 1393-1403, 2015), in a study on statistical learning employing the click-detection paradigm, conclude that more needs to be known about how this paradigm interacts with statistical learning and speech perception. Past results with this monitoring technique have pointed to an end-of-clause effect in parsing-a structural effect-but we here show that the issues are a bit more nuanced. Firstly, we report two Experiments (1a and 1b), which show that reaction times (RTs) are affected by two factors: (a) processing load, resulting in a tendency for RTs to decrease across a sentence, and (b) a perceptual effect which adds to this tendency and moreover helps neutralize differences between sentences with slightly different structures...
July 13, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28704978/evidences-from-rewarding-system-frn-and-p300-effect-in-internet-addiction-in-young-people-short-title-rewarding-system-and-eeg-in-internet-addiction
#17
Michela Balconi, Irene Venturella, Roberta Finocchiaro
The present research explored rewarding bias and attentional deficits in Internet addiction (IA) based on the IAT (Internet Addiction Test) construct, during an attentional inhibitory task (Go/NoGo task). Event-related Potentials (ERPs) effects (Feedback Related Negativity (FRN) and P300) were monitored in concomitance with Behavioral Activation System (BAS) modulation. High-IAT young participants showed specific responses to IA-related cues (videos representing online gambling and videogames) in terms of cognitive performance (decreased Response Times, RTs; and Error Rates, ERs) and ERPs modulation (decreased FRN and increased P300)...
July 12, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28702280/dissecting-limiting-factors-of-the-protein-synthesis-using-recombinant-elements-pure-system
#18
Jun Li, Chi Zhang, Poyi Huang, Erkin Kuru, Eliot T C Forster-Benson, Taibo Li, George M Church
Reconstituted cell-free protein synthesis systems such as the Protein synthesis Using Recombinant Elements (PURE) system give high-throughput and controlled access to in vitro protein synthesis. Here we show that compared with the commercial S30 crude extract based RTS 100 E. coli HY system, the PURE system has less mRNA degradation and produces up to ∼6-fold full-length proteins. However the majority of polypeptides PURE produces are partially translated or inactive since the signal from firefly luciferase (Fluc) translated in PURE is only ∼2/3(rd) of that measured using the RTS 100 E...
2017: Translation
https://www.readbyqxmd.com/read/28700954/cognitive-and-motor-reaction-times-in-obstructive-sleep-apnea-syndrome-a-study-based-on-computerized-measures
#19
Maria Devita, Sonia Montemurro, Andrea Zangrossi, Sara Ramponi, Maurizio Marvisi, Daniele Villani, Maria Clara Raimondi, Paola Merlo, Maria Luisa Rusconi, Sara Mondini
Obstructive Sleep Apnea Syndrome (OSAS) is mainly associated with executive dysfunction. Although delayed reaction times (RTs) in patients with OSAS have been reported, sensitivity of processing speed has not been adequately assessed. This study suggests sensitive and reliable measures to clarify whether different components of information processing speed, i.e. cognitive and motor responses, are equally impaired in OSAS. Thirty-three patients with OSAS were compared with thirty healthy controls. The MoCA test was administered to assess participants' global neuropsychological profile...
July 9, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28698278/on-the-origin-of-reverse-transcriptase-using-crispr-cas-systems-and-their-hyperdiverse-enigmatic-spacer-repertoires
#20
Sukrit Silas, Kira S Makarova, Sergey Shmakov, David Páez-Espino, Georg Mohr, Yi Liu, Michelle Davison, Simon Roux, Siddharth R Krishnamurthy, Becky Xu Hua Fu, Loren L Hansen, David Wang, Matthew B Sullivan, Andrew Millard, Martha R Clokie, Devaki Bhaya, Alan M Lambowitz, Nikos C Kyrpides, Eugene V Koonin, Andrew Z Fire
Cas1 integrase is the key enzyme of the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas adaptation module that mediates acquisition of spacers derived from foreign DNA by CRISPR arrays. In diverse bacteria, the cas1 gene is fused (or adjacent) to a gene encoding a reverse transcriptase (RT) related to group II intron RTs. An RT-Cas1 fusion protein has been recently shown to enable acquisition of CRISPR spacers from RNA. Phylogenetic analysis of the CRISPR-associated RTs demonstrates monophyly of the RT-Cas1 fusion, and coevolution of the RT and Cas1 domains...
July 11, 2017: MBio
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