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https://www.readbyqxmd.com/read/28096477/the-future-of-respiratory-care-results-of-a-new-york-state-survey-of-respiratory-therapists
#1
Stephen G Smith, Lisa M Endee, Lisa A Benz Scott, Pamela L Linden
BACKGROUND: In the current health-care environment, respiratory care may need to make significant changes to academic preparation and clinical practice. The purpose of this research was to assess current needs of respiratory therapists (RTs) in New York State and to understand how RTs perceive their future clinical and academic roles. METHODS: This study employed a descriptive, cross-sectional non-experimental design. Between October and December 2014, a 32-item online survey was distributed via e-mail to the 2,170 members of the New York State Society of Respiratory Care...
January 17, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28095673/a-comparative-study-of-hepatotoxicity-of-pyrrolizidine-alkaloids-retrorsine-and-monocrotaline
#2
Xiaojing Yang, Weiwei Li, Ying Sun, Xiucai Guo, Wenlin Huang, Ying Peng, Jiang Zheng
Many pyrrolizidine alkaloids (PAs) can cause liver injury in animals and humans. Different hepatotoxic PAs can produce similar hepatotoxic effects, but the degree of their toxicities may vary widely. Retrorsine (RTS) and monocrotaline (MCT) share the same core structure (retronecine) and similar metabolic activation pathway. RTS and MCT both produced liver injury but the former was more hepatotoxic than the latter. Enzyme kinetic study demonstrated that the value of Vmax/Km for RTS was 5.5-fold larger than that of MCT...
January 17, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28088543/transformation-of-terrestrial-organic-matter-along-thermokarst-affected-permafrost-coasts-in-the-arctic
#3
George Tanski, Hugues Lantuit, Saskia Ruttor, Christian Knoblauch, Boris Radosavljevic, Jens Strauss, Juliane Wolter, Anna M Irrgang, Justine Ramage, Michael Fritz
The changing climate in the Arctic has a profound impact on permafrost coasts, which are subject to intensified thermokarst formation and erosion. Consequently, terrestrial organic matter (OM) is mobilized and transported into the nearshore zone. Yet, little is known about the fate of mobilized OM before and after entering the ocean. In this study we investigated a retrogressive thaw slump (RTS) on Qikiqtaruk - Herschel Island (Yukon coast, Canada). The RTS was classified into an undisturbed, a disturbed (thermokarst-affected) and a nearshore zone and sampled systematically along transects...
January 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28081253/probability-of-transmission-of-malaria-from-mosquito-to-human-is-regulated-by-mosquito-parasite-density-in-na%C3%A3-ve-and-vaccinated-hosts
#4
Thomas S Churcher, Robert E Sinden, Nick J Edwards, Ian D Poulton, Thomas W Rampling, Patrick M Brock, Jamie T Griffin, Leanna M Upton, Sara E Zakutansky, Katarzyna A Sala, Fiona Angrisano, Adrian V S Hill, Andrew M Blagborough
Over a century since Ronald Ross discovered that malaria is caused by the bite of an infectious mosquito it is still unclear how the number of parasites injected influences disease transmission. Currently it is assumed that all mosquitoes with salivary gland sporozoites are equally infectious irrespective of the number of parasites they harbour, though this has never been rigorously tested. Here we analyse >1000 experimental infections of humans and mice and demonstrate a dose-dependency for probability of infection and the length of the host pre-patent period...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28080109/the-dynamic-range-of-response-set-activation-during-action-sequencing
#5
Lawrence P Behmer, Matthew J C Crump
We show that theories of response scheduling for sequential action can be discriminated on the basis of their predictions for the dynamic range of response set activation during sequencing, which refers to the momentary span of activation states for completed and to-be-completed actions in a response set. In particular, theories allow that future actions in a plan are partially activated, but differ with respect to the width of the range, which refers to the number of future actions that are partially activated...
January 12, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28074459/comparison-of-revised-trauma-score-injury-severity-score-and-trauma-and-injury-severity-score-for-mortality-prediction-in-elderly-trauma-patients
#6
Shahrokh Yousefzadeh-Chabok, Marieh Hosseinpour, Leila Kouchakinejad-Eramsadati, Fatemeh Ranjbar, Reza Malekpouri, Alireza Razzaghi, Zahra Mohtasham-Amiri
BACKGROUND: Trauma is the fifth leading cause of death in patients 65 years and older. This study is a comparison of results of Revised Trauma Score (RTS), Injury Severity Score (ISS), and Trauma and Injury Severity Score (TRISS) in prediction of mortality in cases of geriatric trauma. METHODS: This is a cross-sectional study of records of 352 elderly trauma patients who were admitted to Pour-Sina Hospital in Rasht between 2010 and 2011. Injury scoring systems were compared in terms of specificity, sensitivity, and cut-off points using receiver operating characteristic curve of patient prognosis...
November 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28065475/could-the-rts-s-as01-meningitis-safety-signal-really-be-a-protective-effect-of-rabies-vaccine
#7
REVIEW
Bradford D Gessner, Darryn L Knobel, Anne Conan, Adam Finn
The RTS,S/AS01 malaria vaccine has been associated with meningitis and cerebral malaria safety signals. Key characteristics of the meningitis signal include presence, in the 5-17month but not the 6-12week age group, of delayed and variable meningitis onset after vaccination, and multiple etiologies. For both meningitis and cerebral malaria, the 5-17month old age group control arm had abnormally low incidences while other arms in both age groups had meningitis and cerebral malaria incidences similar to background rates...
January 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28063944/strategies-for-stimulus-selective-stopping-in-the-elderly
#8
Shulan Hsieh, Yu-Chi Lin
This study consisted of two primary aims: (1) to determine if different age groups exhibited different strategies (based on their behavioral reaction time [RT] patterns) while performing a stop-signal task and (2) whether there were age-related differences in reactive and/or proactive control processes. Twenty-four younger adults (20-30years) and 24 older adults (61-76years) participated in this study. Participants performed a stop-signal task, which included a choice RT block, global stop-signal block, and stimulus-selective stop-signal block...
January 5, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28059665/efficacy-of-phase-3-trial-of-rts-s-as01-malaria-vaccine-in-infants-a-systematic-review-and-meta-analysis
#9
Shima Mahmoudi, Hossein Keshavarz
Although vaccines would be the ideal tool for control, prevention, elimination, and eradication of many infectious diseases, developing of parasites vaccines such as malaria vaccine is very complex. The most advanced malaria vaccine candidate is RTS,S, a pre-erythrocytic vaccine for which pivotal phase III trial design is underway. Few recent malaria vaccine review articles have attempted to outline of all clinical trials that have occurred globally and no meta-analysis was performed on efficacy of Phase 3 Trial of RTS, S/AS01 Malaria vaccine up to now in infants...
January 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28048948/mechanism-of-injury-may-influence-infection-risk-from-early-blood-transfusion
#10
Charles A Karcutskie, Jonathan P Meizoso, Juliet J Ray, Davis B Horkan, Xiomara D Ruiz, Carl I Schulman, Nicholas Namias, Kenneth G Proctor
BACKGROUND: Blood transfusion is a known risk factor for infection in trauma patients. Differences based on mechanism of injury have not been well described. We hypothesize that infection risk in trauma patients with early blood transfusion is different based on blunt or penetrating mechanism of injury. PATIENTS AND METHODS: Adults admitted to the trauma intensive care unit from January 2010 through January 2015 were reviewed retrospectively. Those receiving transfusion after 24 h were excluded...
January 3, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28043823/viral-reverse-transcriptases
#11
REVIEW
Luis Menéndez-Arias, Alba Sebastián-Martín, Mar Álvarez
Reverse transcriptases (RTs) play a major role in the replication of Retroviridae, Metaviridae, Pseudoviridae, Hepadnaviridae and Caulimoviridae. RTs are enzymes that are able to synthesize DNA using RNA or DNA as templates (DNA polymerase activity), and degrade RNA when forming RNA/DNA hybrids (ribonuclease H activity). In retroviruses and LTR retrotransposons (Metaviridae and Pseudoviridae), the coordinated action of both enzymatic activities converts single-stranded RNA into a double-stranded DNA that is flanked by identical sequences known as long terminal repeats (LTRs)...
December 30, 2016: Virus Research
https://www.readbyqxmd.com/read/28039508/rothmund-thomson-syndrome-and-osteoma-cutis-in-a-patient-previously-diagnosed-as-cops-syndrome
#12
M C van Rij, M L Grijsen, N M Appelman-Dijkstra, K B M Hansson, C A L Ruivenkamp, K Mulder, R van Doorn, A P Oranje, S G Kant
: We present a patient with poikiloderma, severe osteoporosis and a mild intellectual disability. At the age of 9 years, this patient was proposed to suffer from a novel disease entity designated as calcinosis cutis, osteoma cutis, poikiloderma and skeletal abnormalities (COPS) syndrome. At the age of 35, he was diagnosed with Hodgkin's lymphoma. Recently, biallelic pathogenic variants in the RECQL4 gene were detected (c.1048_1049delAG and c.1391-1G>A), confirming a diagnosis of Rothmund-Thomson syndrome (RTS)...
February 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28035418/realgar-transforming-solution-displays-anticancer-potential-against-human-hepatocellular-carcinoma-hepg2-cells-by-inducing-ros
#13
Peng Song, Peng Chen, Dong Wang, Zhengrong Wu, Qiyu Gao, Aixia Wang, Ruilan Zhu, Yajun Wang, Xin Wang, Longhe Zhao, Ziyun Duan, Shuqian Zhu, Peng Cui, Yang Li, Hongyu Li
Realgar (As4S4), as a mineral drug containing arsenic compound, has been employed in clinical therapy of cancer for its good therapeutic reputation in Chinese traditional medicine. However, large dose of realgar and long period of treatment are necessary for achieving the effective blood medicine concentration due to its low bioavailability resulted from poor solubility. In this study, we obtained realgar transforming solution (RTS) using intrinsic biotransformation in microorganism, and investigated underlying mechanisms of RTS for HepG2 cells...
February 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28033039/the-effects-of-probe-similarity-on-retrieval-and-comparison-processes-in-associative-recognition
#14
Qiong Zhang, Matthew M Walsh, John R Anderson
In this study, we investigated the information processing stages underlying associative recognition. We recorded EEG data while participants performed a task that involved deciding whether a probe word triple matched any previously studied triple. We varied the similarity between probes and studied triples. According to a model of associative recognition developed in the Adaptive Control of Thought-Rational cognitive architecture, probe similarity affects the duration of the retrieval stage: Retrieval is fastest when the probe is similar to a studied triple...
February 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28028781/a-meta-analysis-of-response-time-tests-of-the-sequential-two-systems-model-of-moral-judgment
#15
Jonathan Baron, Burcu Gürçay
The (generalized) sequential two-system ("default interventionist") model of utilitarian moral judgment predicts that utilitarian responses often arise from a system-two correction of system-one deontological intuitions. Response-time (RT) results that seem to support this model are usually explained by the fact that low-probability responses have longer RTs. Following earlier results, we predicted response probability from each subject's tendency to make utilitarian responses (A, "Ability") and each dilemma's tendency to elicit deontological responses (D, "Difficulty"), estimated from a Rasch model...
December 27, 2016: Memory & Cognition
https://www.readbyqxmd.com/read/28028569/functional-testing-and-return-to-sport-following-stabilization-surgery-for-recurrent-lateral-patellar-instability-in-competitive-athletes
#16
Aaron J Krych, Michael P O'Malley, Nick R Johnson, Rohith Mohan, Timothy E Hewett, Michael J Stuart, Diane L Dahm
PURPOSE: Medial patellofemoral ligament (MPFL) reconstruction and tibial tubercle osteotomy are commonly used to treat recurrent lateral patellar instability, yet there are limited available data on return to sport (RTS) following these procedures. The purpose of this study is to evaluate patient factors associated with excellent functional outcomes, including successful RTS, following surgical stabilization including MPFL reconstruction in competitive athletes with recurrent lateral patellar instability...
December 27, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28028199/idiosyncratic-patterns-of-representational-similarity-in-prefrontal-cortex-predict-attentional-performance
#17
Jeongmi Lee, Joy J Geng
: The efficiency of finding an object in a crowded environment depends largely on the similarity of non-targets to the search target. Models of attention theorize that the similarity is determined by representations stored within an "attentional template" held in working memory. However, the degree to which the contents of the attentional template are individually-unique and where those idiosyncratic representations are encoded in the brain, are unknown. We investigated this problem using representational similarity analysis (RSA) of human fMRI data to measure the common and idiosyncratic representations of famous face morphs during an identity categorization task; data from the categorization task were then used to predict performance on a separate identity search task...
December 27, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28028189/implementation-of-a-%C3%AE-agonist-airway-clearance-protocol-in-a-pediatric-icu
#18
Gary R Lowe, J Randy Willis, Shasha Bai, Mark J Heulitt
BACKGROUND: Respiratory therapist (RT)-driven protocols have been in use for over 30 years. Protocols have been reported to decrease unnecessary or harmful therapy, health-care costs, and hospital stay. This study represents the evaluation of an original respiratory care protocol in the pediatric ICU at Arkansas Children's Hospital for β-agonist and airway clearance interventions where one did not exist. METHODS: This project was composed of 2 parts: a survey administered to RTs and licensed independent practitioners and a retrospective review of outcome data comparing a therapist-driven β-agonist/airway clearance protocol with physician-directed respiratory care ordering in a patient population admitted for acute respiratory failure...
December 27, 2016: Respiratory Care
https://www.readbyqxmd.com/read/28027995/a-systematic-review-and-network-meta-analysis-of-neoadjuvant-therapy-combined-with-surgery-for-patients-with-resectable-esophageal-squamous-cell-carcinoma
#19
REVIEW
Yuanwei Huang, Haidong Wang, Ganfeng Luo, Yanting Zhang, Li Wang, Ke Li
BACKGROUND: The role of neoadjuvant therapy combined with surgery for treating esophageal squamous cell carcinoma (ESCC) remains controversial. We performed a network meta-analysis to synthesize direct and indirect evidence to identify the optimal therapeutic method for ESCC. METHODS: We identified 15 randomized controlled trials that compared any of the following 4 therapeutic measures: surgery alone (S), preoperative chemotherapy followed by surgery (CTS), preoperative radiotherapy followed by surgery (RTS), and preoperative chemoradiotherapy followed by surgery (CRTS)...
December 24, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/28025015/developmental-trajectories-of-event-related-potentials-related-to-working-memory
#20
Catarina I Barriga-Paulino, Elena I Rodríguez-Martínez, Antonio Arjona, Manuel Morales, Carlos M Gómez
Working memory is an important cognitive function, and it is crucial to better understand its neurophysiological mechanisms. The developmental trajectories of the Event Related Potentials related to this important function have hardly been studied. However, these ERPs may provide some clues about the individual state of maturation, as has been demonstrated for anatomical brain images. The present study aims to determine the behavioral and neurophysiological development of Working Memory (WM) processes. For this purpose, 170 subjects with ages ranging from 6 to 26 years performed a visual Delayed Match-to-Sample task (DMTS)...
December 23, 2016: Neuropsychologia
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