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https://www.readbyqxmd.com/read/29341785/total-sleep-deprivation-does-not-significantly-degrade-semantic-encoding
#1
K A Honn, D A Grant, J M Hinson, P Whitney, Hpa Van Dongen
Sleep deprivation impairs performance on cognitive tasks, but it is unclear which cognitive processes it degrades. We administered a semantic matching task with variable stimulus onset asynchrony (SOA) and both speeded and self-paced trial blocks. The task was administered at the baseline and 24 hours later after 30.8 hours of total sleep deprivation (TSD) or matching well-rested control. After sleep deprivation, the 20% slowest response times (RTs) were significantly increased. However, the semantic encoding time component of the RTs remained at baseline level...
January 17, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29341295/sustainability-of-the-australian-radiation-oncology-workforce-a-survey-of-radiation-therapists-and-radiation-oncology-medical-physicists
#2
Georgia K B Halkett, Melissa N Berg, Lauren J Breen, David Cutt, Michael Davis, Martin A Ebert, Desley Hegney, Michael House, Rachel Kearvell, Leanne Lester, Sharon Maresse, Jan McKay
This study aimed to determine and compare Radiation Therapists' (RTs') and Radiation Oncology Medical Physicists' (ROMPs') perspectives about their profession and workplace, satisfaction with career progression opportunities, and leaving the current workplace. RTs and ROMPs who were currently or had previously worked in Australia were invited to complete an online survey. Univariate and multivariate methods were used for analysis. Participants were 342 RTs and 112 ROMPs with estimated response rates of 14% and 26% respectively...
January 17, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29336726/parallel-dual-task-processing-and-task-shielding-in-older-and-younger-adults-behavioral-and-diffusion-model-results
#3
Markus Janczyk, Patrik Mittelstädt, Carolin Wienrich's
Background/Study Context: The study investigated the Backward Crosstalk Effect (BCE) in dual-task situations, that is, the observation that Task 2 characteristics can even influence Task 1 processing. This observation suggests that the tasks are processed in parallel. Besides determining the existence of a BCE in a group of older adults, the size of the BCE was compared to that in a group of younger adults. Importantly, recent studies yielded unclear results. METHODS: Twenty-four younger and older adults (19-27 and 58-71 years of age, respectively) performed a dual-task experiment, where Task 1 required a left/right manual response and Task 2 required a left/right foot response...
January 16, 2018: Experimental Aging Research
https://www.readbyqxmd.com/read/29330680/the-illusion-of-control-sequential-dependencies-underlie-contingent-attentional-capture
#4
Greg Huffman, Victoria M Antinucci, Jay Pratt
The degree to which humans have top-down control over which information they process remains a central debate within the attention literature. Most of the evidence supporting the top-down control of visuospatial attention has come from cueing paradigms in which target stimuli are preceded by cues that are similar or dissimilar from the target. These studies find that the cues similar to targets capture attention, but dissimilar cues do not, suggesting the top-down control of attention. Here, we used a modified cueing paradigm to investigate an alternative possibility that the cue type differences are due to sequential dependency effects occurring between cue and target processing rather than the top-down control of attention...
January 12, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29330371/transcriptional-inaccuracy-threshold-attenuates-differences-in-rna-dependent-dna-synthesis-fidelity-between-retroviral-reverse-transcriptases
#5
Alba Sebastián-Martín, Verónica Barrioluengo, Luis Menéndez-Arias
In M13mp2 lacZα forward mutation assays measuring intrinsic fidelity of DNA-dependent DNA synthesis, wild-type human immunodeficiency virus type 1 (HIV-1) RTs of group M/subtype B previously showed >10-fold higher error rates than murine leukaemia virus (MLV) and avian myeloblastosis virus (AMV) RTs. An adapted version of the assay was used to obtain error rates of RNA-dependent DNA synthesis for several RTs, including wild-type HIV-1BH10, HIV-1ESP49, AMV and MLV RTs, and the high-fidelity mutants of HIV-1ESP49 RT K65R and K65R/V75I...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329968/reexamining-unconscious-response-priming-a-liminal-prime-paradigm
#6
Maayan Avneon, Dominique Lamy
Research on the limits of unconscious processing typically relies on the subliminal-prime paradigm. However, this paradigm is limited in the issues it can address. Here, we examined the implications of using the liminal-prime paradigm, which allows comparing unconscious and conscious priming with constant stimulation. We adapted an iconic demonstration of unconscious response priming to the liminal-prime paradigm. On the one hand, temporal attention allocated to the prime and its relevance to the task increased the magnitude of response priming...
January 9, 2018: Consciousness and Cognition
https://www.readbyqxmd.com/read/29327649/the-effect-of-auditory-stimulus-training-on-swimming-start-reaction-time
#7
Christopher Papic, Peter Sinclair, Che Fornusek, Ross Sanders
Task-specific auditory training can improve sensorimotor processing times of the auditory reaction time (RT). The majority of competitive swimmers do not conduct habitual start training with the electronic horn used to commence a race. We examined the effect of four week dive training interventions on RT and block time (BT) of 10 male adolescent swimmers (age 14.0 ± 1.4 years): dive training with auditory components (speaker and electronic horn) (n = 5) and dive training without auditory components (n = 5)...
January 12, 2018: Sports Biomechanics
https://www.readbyqxmd.com/read/29327268/serum-thiol-levels-and-thiol-disulphide-homeostasis-in-gunshot-injuries
#8
Hasan Buyukaslan, Umut Gulacti, Mehmet Tahir Gökdemir, Ramazan Giden, Hakim Celik, Özcan Erel, Erman Mustafa Dörterler
BACKGROUND: Gunshot injuries result in serious traumatic tissue damage due to high velocity of the bullet, deep penetration, and ballistic effect. Trauma is known to be related with oxidative stress. Serum thiol levels and disulphide/thiol homeostasis are novel oxidative stress biomarkers. In this study, we aimed to investigate serum thiol levels and disulphide/thiol homeostasis in injury patterns of patients admitted to the emergency department with a gunshot injury. METHOD: A total of 128 participants were included in the study...
January 11, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29326958/performance-and-return-to-sport-after-thumb-ulnar-collateral-ligament-repair-in-major-league-baseball-players
#9
Robert A Jack, Kyle R Sochacki, Bryce Gagliano, David M Lintner, Joshua D Harris, Patrick C McCulloch
Background: Acute ruptures of the ulnar collateral ligament (UCL) of the thumb are common injuries in sports. Surgical repair has yielded excellent results and high return-to-sport (RTS) rates in elite athletes. Purpose: To determine (1) the RTS rate in Major League Baseball (MLB) players following thumb UCL repair, (2) postoperative career length and games played per season, (3) pre- and postoperative performance, (4) postoperative performance compared with matched control players, and (5) whether dominant and nondominant hand injuries respond differently...
January 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29318172/clinical-factors-that-predict-a-second-acl-injury-after-acl-reconstruction-and-return-to-sport-preliminary-development-of-a-clinical-decision-algorithm
#10
Mark V Paterno, Bin Huang, Staci Thomas, Timothy E Hewett, Laura C Schmitt
Background: Biomechanical predictors of a second anterior cruciate ligament (ACL) injury after ACL reconstruction (ACLR) and return to sport (RTS) have been identified; however, these measures may not be feasible in a standard clinical environment. Purpose/Hypothesis: The purpose of this study was to evaluate whether standard clinical measures predicted the risk of second ACL injuries. The hypothesis tested was that a combination of strength, function, and patient-reported measures at the time of RTS would predict the risk of second ACL injuries with high sensitivity and specificity...
December 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29305286/clinical-outcomes-of-osteochondral-allograft-transplantation-for-secondary-treatment-of-osteochondritis-dissecans-of-the-knee-in-skeletally-mature-patients
#11
Eric J Cotter, Rachel M Frank, Kevin C Wang, Trifon Totlis, Sarah Poland, Maximillian A Meyer, Brian J Cole
PURPOSE: To report clinical outcomes of osteochondral allograft transplantation (OCA) for skeletally mature patients with osteochondritis dissecans (OCD) lesions of the knee in whom prior surgical intervention has failed, and to describe return-to-sport (RTS) rates and any predictive demographic or preoperative variables associated with a higher likelihood to RTS. METHODS: Patients who underwent OCA by a single surgeon (B.J.C.) between October 1, 2002, and November 30, 2014, for a diagnosis of OCD with a minimum of 2 years' follow-up were included...
January 2, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29304135/simple-reaction-times-to-cyclopean-stimuli-reveal-that-the-binocular-system-is-tuned-to-react-faster-to-near-than-to-far-objects
#12
Gábor Horváth, Vanda A Nemes, János Radó, András Czigler, Béla Török, Péter Buzás, Gábor Jandó
Binocular depth perception is an important mechanism to segregate the visual scene for mapping relevant objects in our environment. Convergent evidence from psychophysical and neurophysiological studies have revealed asymmetries between the processing of near (crossed) and far (uncrossed) binocular disparities. The aim of the present study was to test if near or far objects are processed faster and with higher contrast sensitivity in the visual system. We therefore measured the relationship between binocular disparity and simple reaction time (RT) as well as contrast gain based on the contrast-RT function in young healthy adults...
2018: PloS One
https://www.readbyqxmd.com/read/29288270/unstable-binocular-fixation-affects-reaction-times-but-not-implicit-motor-learning-in-dyslexia
#13
Anna Przekoracka-Krawczyk, Alicja Brenk-Krakowska, Pawel Nawrot, Patrycja Rusiak, Ryszard Naskrecki
Purpose: Individuals with developmental dyslexia suffer not only from reading problems as more general motor deficits can also be observed in this patient group. Both psychometric clinical tests and objective eyetracking methods suggest that unstable binocular fixation may contribute to reading problems. Because binocular instability may cause poor eye-hand coordination and impair motor control, the primary aim of this study was to explore in dyslexic subjects the influence of unstable binocular fixation on reaction times (RTs) and implicit motor learning (IML), which is one of the fundamental cerebellar functions...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29280925/ontemporary-utilization-of-resuscitative-thoracotomy-results-from-the-aast-aortic-occlusion-for-resuscitation-in-trauma-and-acute-care-surgery-aorta-multicenter-registry
#14
Joseph DuBose, Timothy Fabian, Tiffany Bee, Laura J Moore, John B Holcomb, Megan Brenner, David Skarupa, Kenji Inaba, Todd E Rasmussen, David Turay, Thomas M Scalea
INTRODUCTION: Several reviews of Resuscitative thoracotomy (RT) use over the last 5 decades have been conducted, most recently the evidence-based practice management guideline (PMG) of the Eastern Association for the Surgery of Trauma (EAST). The present study was designed to examine contemporary RT utilization and outcomes compared to historical data (n = 10,238) from the EAST PMG review from published series 1974 - 2013. METHODS: The AAST AORTA registry was utilized to identify patients undergoing RT in the ED from Nov 2013 to Dec 2016...
December 26, 2017: Shock
https://www.readbyqxmd.com/read/29280680/smarcb1-deficient-tumors-of-childhood-a-practical-guide
#15
Bruce R Pawel
The SMARCB1 gene ( INI1, BAF47) is a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex, involved in the epigenetic regulation of gene transcription. SMARCB1 acts as a tumor suppressor gene, and loss of function of both alleles gives rise to SMARCB1-deficient tumors. The prototypical SMARCB1-deficient tumor is the malignant rhabdoid tumor (MRT) which was first described in the kidney but also occurs in soft tissue, viscera, and the brain (where it is referred to as atypical teratoid rhabdoid tumor or AT/RT)...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29280048/sequence-effects-of-the-involuntary-and-the-voluntary-components-of-symbolic-cueing
#16
Qian Qian, Feng Wang, Miao Song, Yong Feng, Keizo Shinomori
The orienting of attention has been found to be influenced by the previous cueing status in a spatial-cueing paradigm. The explanation for this sequence effect remains uncertain. This study separated the involuntary and the voluntary components of arrow cueing by manipulating the predicted target locations. For example, a left arrow cue may have indicated that the target was more likely to appear at the up location. Therefore, three trial types were repeated or switched between trials: cued (targets appeared along the direction of the arrows), predicted (targets appeared at the locations predicted by the arrows), and unrelated (targets appeared at the other two locations, neither cued nor predicted)...
December 26, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29276390/trial-level-regressor-modulation-for-functional-magnetic-resonance-imaging-designs-requiring-strict-periodicity-of-stimulus-presentations-illustrated-using-a-go-no-go-task
#17
Michael A Motes, Neena K Rao, Ehsan Shokri-Kojori, Hsueh-Sheng Chiang, Michael A Kraut, John Hart
Computer-based assessment of many cognitive processes (eg, anticipatory and response readiness processes) requires the use of invariant stimulus display times (SDT) and intertrial intervals (ITI). Although designs with invariant SDTs and ITIs have been used in functional magnetic resonance imaging (fMRI) research, such designs are problematic for fMRI studies because of collinearity issues. This study examined regressor modulation with trial-level reaction times (RT) as a method for improving signal detection in a go/no-go task with invariant SDTs and ITIs...
2017: Magnetic Resonance Insights
https://www.readbyqxmd.com/read/29275329/amino-acid-residues-in-hiv-2-reverse-transcriptase-that-restrict-the-development-of-nucleoside-analogue-resistance-through-the-excision-pathway
#18
Mar Álvarez, Maria Nevot, Jesus Mendieta, Miguel A Martinez, Luis Menéndez-Arias
Nucleoside reverse transcriptase (RT) inhibitors (NRTIs) are the backbone of current antiretroviral treatments. However, emergence of viral resistance against NRTIs is a major threat to their therapeutic effectiveness. In HIV-1, NRTI resistance-associated mutations either reduce RT-mediated incorporation of NRTI triphosphates (discrimination mechanism) or confer an ATPmediated nucleotide excision activity that removes the inhibitor from the 3'-terminus of DNA primers, enabling further primer elongation (excision mechanism)...
December 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29274899/repolarization-in-perfused-myocardium-predicts-reperfusion-ventricular-tachyarrhythmias
#19
Olesya G Bernikova, Ksenia A Sedova, Natalia V Arteyeva, Aleksey O Ovechkin, Sergey N Kharin, Dmitry N Shmakov, Jan E Azarov
BACKGROUND: Aim of the study was to find out which myocardial repolarization parameters predict reperfusion ventricular tachycardia and fibrillation (VT/VF) and determine how these parameters express in ECG. METHODS: Coronary occlusion and reperfusion (30/30min) was induced in 24 cats. Local activation and end of repolarization times (RT) were measured in 88 intramyocardial leads. Computer simulations of precordial electrograms were performed. RESULTS: Reperfusion VT/VF developed in 10 animals...
December 6, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29273820/effects-of-caffeine-on-reaction-time-are-mediated-by-attentional-rather-than-motor-processes
#20
Christopher W N Saville, H M de Morree, Neil M Dundon, S M Marcora, C Klein
BACKGROUND: Caffeine has a well-established effect on reaction times (RTs) but the neurocognitive mechanisms underlying this are unclear. METHODS: In the present study, 15 female participants performed an oddball task after ingesting caffeine or a placebo, and electroencephalographic data were obtained. Single-trial P3b latencies locked to the stimulus and to the response were extracted and mediation models were fitted to the data to test whether caffeine's effect on RTs was mediated by its effect on either type of P3b latencies...
December 23, 2017: Psychopharmacology
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