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https://www.readbyqxmd.com/read/29678086/implementing-systems-medicine-a-medical-informatics-perspective
#1
Matthias Ganzinger, Matthias Gietzelt, Christian Karmen, Blanca Flores, Petra Knaup
Systems medicine is a paradigm for translating in silico methods developed for modelling biological systems into the field of medicine. Such approaches rely on the integration of as many data sources as possible, both in the dimension of disease knowledge and patient data. This is a challenging task that can only be implemented in clinical routine with the help of suitable information technology from the field of Medical Informatics. For the research project "Clinically-applicable, omics-based assessment of survival, side effects, and targets in multiple myeloma" (CLIOMMICS) we developed a prototypical systems medicine application system...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29676142/-analysis-of-acne-animal-model-based-on-chinese-and-western-medicine-clinical-symptoms-characteristic
#2
Zhen-Na Fu, Ting Wang, Ming Bai, Ming-San Miao
This paper aimed to analyze the existing acne animal model based on the characteristics of acne clinical symptoms between Chinese and western medicine, in order to provide reference for the establishment of the rational acne animal model. Relevant literatures at home and abroad in recent years were reviewed to summarize the research progress of diagnostic criteria and drug treatment of acne with Chinese and western medicine, and analyze the existing acne animal model. The animal acne models were pathological models, and mainly reflected the clinical indicators of western medicine...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29673616/nxy-059-a-failed-stroke-neuroprotectant-offers-no-protection-to-stem-cell-derived-human-neurons
#3
Ana Antonic, Mirella Dottori, Malcolm R Macleod, Geoffrey A Donnan, David W Howells
BACKGROUND: Developing new medicines is a complex process where understanding the reasons for both failure and success takes us forward. One gap in our understanding of most candidate stroke drugs before clinical trial is whether they have a protective effect on human tissues. NXY-059 is a spin-trap reagent hypothesized to have activity against the damaging oxidative biology which accompanies ischemic stroke. Re-examination of the preclinical in vivo dataset for this agent in the wake of the failed SAINT-II RCT highlighted the presence of a range of biases leading to overestimation of the magnitude of NXY-059's effects in laboratory animals...
April 16, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29671037/-geriatric-intensive-care-patients-perspectives-and-limits-of-geriatric-intensive-care-medicine
#4
REVIEW
U Müller-Werdan, H-J Heppner, G Michels
Critically ill geriatric patients are vitally endangered due to the aging processes of organs, the frequently existing multimorbidity with subsequent polypharmacy and the typical geriatric syndrome of functional impairments. Aging processes in organs lower the clinical threshold for organ dysfunction and organ failure. Physiological organ aging processes with practical consequences for intensive care medicine are atypical manifestion of sepsis in immunosenescence, altered pharmacokinetics, reduced tolerance to hypovolemia due to proportionally reduced water compartment of the body in old age, the frequently only apparently normal function of the kidneys and the continuous reduction in pulmonary function in old age...
April 18, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29666139/last-year-of-life-study-cologne-lyol-c-protocol-for-a-cross-sectional-mixed-methods-study-to-examine-care-trajectories-and-transitions-in-the-last-year-of-life-until-death
#5
Julia Strupp, Gloria Hanke, Nicolas Schippel, Holger Pfaff, Ute Karbach, Christian Rietz, Raymond Voltz
INTRODUCTION: The last year of life constitutes a particularly vulnerable phase for patients, involving nearly all health and social care structures. Yet, little scientific evidence is available that provides insight into the trajectories including the number and types of care setting transitions, transitions into palliative care and the dying phase. Only few studies have focused on difficulties associated with having to move between health and social care settings in the last year of life, although patients face a significant risk of adverse events...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29629198/patient-health-engagement-phe-model-in-enhanced-recovery-after-surgery-eras-monitoring-patients-engagement-and-psychological-resilience-in-minimally-invasive-thoracic-surgery
#6
REVIEW
Guendalina Graffigna, Serena Barello
In the last decade, the humanization of medicine has contributed to an important shift in medical paradigms (from a doctor-centered to a patient-centered approach to care). This paradigm shift promoted a greater acknowledgement of patient engagement as a crucial asset for healthcare due to its benefits on both clinical outcomes and healthcare sustainability. Particularly, patient engagement should be considered a vital parameter for the healthcare system as well as it is a marker of the patients' ability to be resilient to the illness experience and thus to be an effective manager of his/her own health after the diagnosis...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29629060/reliability-and-validity-assessment-of-gastrointestinal-dystemperaments-questionnaire-a-novel-scale-in-persian-traditional-medicine
#7
Hamidreza Hoseinzadeh, Ali Taghipour, Mahdi Yousefi, Hamidreza Rostamani
Background: Development of a questionnaire based on the resources of Persian traditional medicine seems necessary. One of the problems faced by practitioners of traditional medicine is the different opinions regarding the diagnosis of general temperament or temperament of member. One of the reasons is the lack of validity tools, and it has led to difficulties in training the student of traditional medicine and the treatment of patients. The differences in the detection methods, have given rise to several treatment methods...
February 2018: Electronic Physician
https://www.readbyqxmd.com/read/29627144/-assessing-bioethics-education-teaching-to-be-virtuous-doctors-or-just-doctors-with-practical-ethical-skills
#8
Montse Esquerda, Josep Pifarré, Helena Roig, Ester Busquets, Oriol Yuguero, Joan Viñas
OBJECTIVE: In the last decades, bioethics has been incorporated into the academic training of the Medical Schools. Some studies analyze the ethical-moral development of medical students and the effect of ethical education in other countries. This evaluation is done by measuring Kohlberg's moral reasoning (virtuous doctors), or ethical sensitivity to resolve clinical cases (physicians with ethical skills). The following study is proposed to assess the impact of bioethics training on these two variables, in Spanish medical students...
April 4, 2018: Atencion Primaria
https://www.readbyqxmd.com/read/29626412/standardization-of-autoimmune-testing-is-it-feasible
#9
Evanthia Monogioudi, Gustavo Martos, Dana Petronela Hutu, Heinz Schimmel, Pier Luigi Meroni, Joanna Sheldon, Ingrid Zegers
Correct measurement of autoantibodies is essential for the diagnosis of autoimmune diseases. However, due to the variability of autoantibody results and the heterogeneity of testing, wrong diagnosis is a reality. For this and more reasons, harmonization of testing is of the outmost importance. In this review we have summarized the factors contributing to this variability. The ways with which the working group on harmonization of autoantibody testing of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has been trying to tackle the issue with the production and correct use of certified reference materials (CRMs), is discussed...
April 7, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29624854/an-evaluation-of-the-trimmed-mean-approach-in-clinical-trials-with-dropout
#10
Ming-Dauh Wang, Jiajun Liu, Geert Molenberghs, Craig Mallinckrodt
The trimmed mean is a method of dealing with patient dropout in clinical trials that considers early discontinuation of treatment a bad outcome rather than leading to missing data. The present investigation is the first comprehensive assessment of the approach across a broad set of simulated clinical trial scenarios. In the trimmed mean approach, all patients who discontinue treatment prior to the primary endpoint are excluded from analysis by trimming an equal percentage of bad outcomes from each treatment arm...
April 6, 2018: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/29610953/judicial-precedent-based-clinical-practice-guidelines-of-propofol-in-sedative-esthetic-surgery
#11
Duk Hee Lee, Joo Hyun Woo, Seung Eun Hong
BACKGROUND: Propofol is has been widely used for sedation in the field of esthetic surgery because of its favorable pharmacokinetic profile. Propofol sedation-induced side effects are rare. However, when present, they can be serious. The number of malpractice claims associated with propofol sedation has increased in recent years. This study aims to show which procedures lead to the most claims in the field of esthetic surgery through a review of Korean precedents. METHODS: Thirteen precedent cases of propofol sedation in the field of esthetic surgery were collected between 2000 and 2016...
April 2, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29609830/safety-data-and-withdrawal-of-hepatotoxic-drugs
#12
Samy Babai, Laurent Auclert, Hervé Le-Louët
BACKGROUND AND AIM: The occurrence of drug induced liver injury (DILI) is the most common reason of post-marketing withdrawals. DILI in humans is difficult to predict using in vitro cytotoxicity screening and animal studies. A review of hepatotoxicity data was performed with the aim of identifying relevant factors that could have predicted the occurrence of serious DILI. METHODS: The drugs withdrawn from the market due to hepatotoxicity in Europe and/or in USA either by marketing authorization holders or by Regulatory agencies from 1997 to 2016 were selected...
February 21, 2018: Thérapie
https://www.readbyqxmd.com/read/29604225/bedside-reasoning-on-causes-and-mechanisms-of-diseases-in-the-era-of-precision-medicine-a-timeless-story
#13
REVIEW
Dan Lipsker
This is a short reflection about bedside reasoning in clinical medicine, emphasizing the importance of distinguishing between causes and mechanisms of diseases. All complex/sporadic diseases result from interactions between a genetic predisposition and environmental factors. The main disease mechanisms resulting in clinical signs involve inflammation, insult of vessels or nerves, pharmacological or hormonal dysfunction, altered metabolism and overload, tumoral proliferations, intrinsic dysfunction, malformation and traumatism...
March 31, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29600638/-contamination-distribution-and-control-measures-of-aflatoxins-in-chinese-herbal-pieces
#14
REVIEW
Cheng Zhang, Xiao-Wen Dou, Lei Zhang, Wei-Jun Kong, Ming Zhao, Zhen Ouyang, Mei-Hua Yang
As an important part of traditional medicine in China, traditional Chinese medicine(TCM) plays a significant role because of its unique medical efficiency, less adverse reactions and extensive resources. However, in recent years, the aflatoxins in medicinal herbs have been detected excessive both at home and abroad, seriously affecting the reputation and credibility of traditional Chinese medicine. In this paper, the current status of aflatoxins contamination in medicinal herbs was analyzed, and the internal and external factors of aflatoxins contamination in traditional Chinese medicine were also summarized...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29599811/the-pilot-survey-of-the-perception-on-the-practice-pattern-diagnosis-and-treatment-on-korean-medicine-insomnia-focusing-on-the-difference-between-korean-medical-neuropsychiatry-specialists-and-korean-medical-general-practitioners
#15
Jung-Hwa Lim, Jin-Hyung Jeong, Sang-Ho Kim, Kyeong-Ok Kim, Seung-Yeon Lee, Sang-Hyup Lee, Bo-Kyung Kim
Introduction: This study aims to investigate the clinical practice states on the diagnosis and treatment for insomnia between Korean medical general practitioners (KMGPs) and Korean medical neuropsychiatry specialists (KMNPSs). Methods: We distributed questionnaires via email or in person to 1,017 KMGPs and via email to 165 KMNPSs. We collected and analyzed responses from 305 (30.00%) KMGPs and 53 (32.12%) KMNPSs. Results: Most KMGPs and KMNPSs responded that the number of new patients visiting the clinic for treatment of insomnia was less than 10 per month (78...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29597235/practical-issues-in-vitamin-d-replacement
#16
Robert A Adler
Practical clinical guidance for vitamin D assessment and management relies on a strong evidence base, but unfortunately there are many deficiencies in our current knowledge. For the general population the Institute of Medicine recommendations are likely to provide adequate vitamin D levels without harms. Thus, most adults should ingest 600-800 IU (international units) in diet and supplements with up to 4,000 IU daily likely to be safe. In certain populations, such as those with osteoporosis or after bariatric surgery, it is important to know the levels of circulating 25-hydroxyvitamin D, but general screening has not been shown to improve health...
2018: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/29594372/short-term-outcomes-of-heart-failure-patients-with-reduced-and-preserved-ejection-fraction-after-acute-decompensation-according-to-the-final-destination-after-emergency-department-care
#17
Òscar Miró, V Íctor Gil, Francisco Javier Martín-Sánchez, Javier Jacob, Pablo Herrero, Aitor Alquézar, Lluís Llauger, Sira Aguiló, Gemma Martínez, José Ríos, Alberto Domínguez-Rodríguez, Veli-Pekka Harjola, Christian Müller, John Parissis, W Frank Peacock, Pere Llorens
AIMS: To compare short-term outcomes after an episode of acute heart failure (AHF) in patients with reduced and preserved ejection fractions (HFrEF, < 40%; and HFpEF, > 49%; respectively) according to their destinations after emergency department (ED) care. METHODS AND RESULTS: This secondary analysis of the EAHFE Registry (consecutive AHF patients diagnosed in 41 Spanish EDs) investigated 30-day all-cause mortality, in-hospital all-cause mortality, prolonged hospitalisation (> 7 days), and 30-day post-discharge ED revisit due to AHF, all-cause death, and combined endpoint (ED revisit/death) in 5829 patients with echocardiographically documented HFrEF and HfpEF (HFrEF/HFpEF: 1,442/4,387)...
March 28, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29589042/-hemostyptics-for-treatment-of-junctional-vascular-injuries-management-of-traumatic-vascular-injuries-at-the-transition-from-trunk-to-extremities
#18
REVIEW
D C Hinck, S Wipper, E S Debus
BACKGROUND: Uncontrolled post-traumatic bleeding is still the leading cause of death among trauma patients. In situations of mass casualty incidents (MASCAL) and military conflicts the treatment of uncontrolled critical bleeding is a challenge and associated with a worse outcome due to the austere environment; however, even under optimal treatment circumstances in situations of individual medicine the severity of vascular trauma is underestimated. As a consequence, this leads to a poorer prognosis for patients with (vascular) injuries...
March 27, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29588951/magnitude-and-factors-associated-with-nonadherence-to-antiepileptic-drug-treatment-in-africa-a-cross-sectional-multisite-study
#19
Fredrick Ibinda, Peter Odermatt, Symon M Kariuki, Angelina Kakooza-Mwesige, Ryan G Wagner, Seth Owusu-Agyei, Honorati Masanja, Anthony K Ngugi, Caroline K Mbuba, Victor C K Doku, Brian G Neville, Josemir W Sander, Charles R J C Newton
Objectives: The epilepsy treatment gap is large in low- and middle-income countries, but the reasons behind nonadherence to treatment with antiepileptic drugs (AEDs) across African countries remain unclear. We investigated the extent to which AEDs are not taken and associated factors in people with active convulsive epilepsy (ACE) identified in cross-sectional studies conducted in five African countries. Methods: We approached 2,192 people with a confirmed diagnosis of ACE for consent to give blood voluntarily...
June 2017: Epilepsia Open
https://www.readbyqxmd.com/read/29582953/-to-be-a-resident-in-the-department-of-medicine
#20
Matan Fischer, Zahi Abu Ghosh, Limor Rubin, Fadi Kharouf, Oshrat Ayalon, Danna Dror, Batla Falah, Dror Mevorach
Sir William Osler is considered to be one of the fathers of modern medicine who pioneered the practice of bedside teaching of clinical medicine for medical students and residents. Osler was well known as a diagnostician and outstanding therapist with a humanized approach and rare didactic capabilities. Medical training at Hadassah is built on the central tenets of Osler's approach, incorporating the tremendous advances in science and medicine. Training for residents in Internal Medicine is designed to develop a broad base of medical and, if possible, scientific knowledge, as well as skills and competencies to deliver a high standard of patient care...
March 2018: Harefuah
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