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https://www.readbyqxmd.com/read/29222179/hpv-vaccination-rate-in-french-adolescent-girls-an-example-of-vaccine-distrust
#1
Hervé Lefèvre, Cécile Schrimpf, Marie Rose Moro, Jonathan Lachal
OBJECTIVES: To explore the clinical issues of human papillomavirus (HPV) vaccination to develop explanatory hypotheses for the low level of vaccination among adolescent girls in France where the full course coverage is low (<15%). DESIGN: We used semistructured interviews. Our qualitative and phenomenological procedure applied interpretative phenomenological analysis. PARTICIPANTS: 16 physicians regularly faced with the prescription of HPV vaccine, represented several medical specialties (paediatrics, general practice, internal medicine, gynaecology), with hospitalist or private practices...
December 8, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29221302/the-society-for-translational-medicine-clinical-practice-guidelines-for-mechanical-ventilation-management-for-patients-undergoing-lobectomy
#2
REVIEW
Shugeng Gao, Zhongheng Zhang, Alessandro Brunelli, Chang Chen, Chun Chen, Gang Chen, Haiquan Chen, Jin-Shing Chen, Stephen Cassivi, Ying Chai, John B Downs, Wentao Fang, Xiangning Fu, Martínez I Garutti, Jianxing He, Jie He, Jian Hu, Yunchao Huang, Gening Jiang, Hongjing Jiang, Zhongmin Jiang, Danqing Li, Gaofeng Li, Hui Li, Qiang Li, Xiaofei Li, Yin Li, Zhijun Li, Chia-Chuan Liu, Deruo Liu, Lunxu Liu, Yongyi Liu, Haitao Ma, Weimin Mao, Yousheng Mao, Juwei Mou, Calvin Sze Hang Ng, René H Petersen, Guibin Qiao, Gaetano Rocco, Erico Ruffini, Lijie Tan, Qunyou Tan, Tang Tong, Haidong Wang, Qun Wang, Ruwen Wang, Shumin Wang, Deyao Xie, Qi Xue, Tao Xue, Lin Xu, Shidong Xu, Songtao Xu, Tiansheng Yan, Fenglei Yu, Zhentao Yu, Chunfang Zhang, Lanjun Zhang, Tao Zhang, Xun Zhang, Xiaojing Zhao, Xuewei Zhao, Xiuyi Zhi, Qinghua Zhou
Patients undergoing lobectomy are at significantly increased risk of lung injury. One-lung ventilation is the most commonly used technique to maintain ventilation and oxygenation during the operation. It is a challenge to choose an appropriate mechanical ventilation strategy to minimize the lung injury and other adverse clinical outcomes. In order to understand the available evidence, a systematic review was conducted including the following topics: (I) protective ventilation (PV); (II) mode of mechanical ventilation [e...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29218880/causal-inference-on-electronic-health-records-to-assess-blood-pressure-treatment-targets-an-application-of-the-parametric-g-formula
#3
Kipp W Johnson, Benjamin S Glicksberg, Rachel A Hodos, Khader Shameer, Joel T Dudley
Hypertension is a major risk factor for ischemic cardiovascular disease and cerebrovascular disease, which are respectively the primary and secondary most common causes of morbidity and mortality across the globe. To alleviate the risks of hypertension, there are a number of effective antihypertensive drugs available. However, the optimal treatment blood pressure goal for antihypertensive therapy remains an area of controversy. The results of the recent Systolic Blood Pressure Intervention Trial (SPRINT) trial, which found benefits for intensive lowering of systolic blood pressure, have been debated for several reasons...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29216479/diagnosis-of-deep-vein-thrombosis-recurrence-ultrasound-criteria
#4
REVIEW
Mario Maufus, Antoine Elias, Marie-Thérèse Barrellier, Gilles Pernod
INTRODUCTION: Recurrent deep vein thrombosis (DVT) is often suspected in patients after anticoagulant drug withdrawal. The clinical signs can be confused with the onset of post-thrombotic syndrome. For these reasons, diagnosis of DVT recurrence must rely on an accurate method. MATERIALS AND METHODS: In order to assess this challenging clinical issue, we performed an overview of the literature regarding ultrasound criteria for the diagnosis of recurrent DVT through a Medline search, which included articles published from January 1, 1980 to February 20, 2017...
November 14, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29209959/improving-the-level-and-quality-of-ethics-review-in-chinese-medicine-and-integrative-medicine
#5
Cheng-Bin Zhang, En-Chang Li
Three features of ethics review in Chinese medicine (CM) and integrative medicine (IM) were put forward in this paper. It is consistent with the principles of ethical review in Western medicine; it has to be compliant with the laws of CM and IM; emphasis should be laid on the review of clinical practice facts and experience. Three problems were pointed out. The characteristics of CM and IM are not distinctive enough, operation procedures need to be refined and effectiveness remains to be improved. Based on the mentioned above, seven measures were proposed to improve the level and quality of ethics review in CM and IM, including better brand awareness, considerable tolerance, treatment based on disease differentiation and syndrome differentiation, scientific review and toxicity and side effects of CM, perfection of the ethics review system, reasonable procedures of ethics review and more specialized ethics review workers...
December 5, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29209722/association-between-treatment-by-locum-tenens-internal-medicine-physicians-and-30-day-mortality-among-hospitalized-medicare-beneficiaries
#6
Daniel M Blumenthal, Andrew R Olenski, Yusuke Tsugawa, Anupam B Jena
Importance: Use of locum tenens physicians has increased in the United States, but information about their quality and costs of care is lacking. Objective: To evaluate quality and costs of care among hospitalized Medicare beneficiaries treated by locum tenens vs non-locum tenens physicians. Design, Setting, and Participants: A random sample of Medicare fee-for-service beneficiaries hospitalized during 2009-2014 was used to compare quality and costs of hospital care delivered by locum tenens and non-locum tenens internal medicine physicians...
December 5, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29205435/relative-efficiency-of-precision-medicine-designs-for-clinical-trials-with-predictive-biomarkers
#7
Weichung Joe Shih, Yong Lin
Prospective randomized clinical trials addressing biomarkers are time consuming and costly, but are necessary for regulatory agencies to approve new therapies with predictive biomarkers. For this reason, recently, there have been many discussions and proposals of various trial designs and comparisons of their efficiency in the literature. We compare statistical efficiencies between the marker-stratified design and the marker-based precision medicine design regarding testing/estimating 4 hypotheses/parameters of clinical interest, namely, treatment effects in each marker-positive and marker-negative cohorts, marker-by-treatment interaction, and the marker's clinical utility...
December 4, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29204950/-physiotherapy-in-pain-medicine-further-treatment-after-a-multimodal-pain-therapy-program
#8
Elisabeth Dean
BACKGROUND: Chronic pain is a global health challenge for both the individual patient and the healthcare community. Multimodal Pain Management, as one of the possible therapies for patients with chronic pain, provides a comprehensive tool that places equally high demands on therapists and patients and is consistently recommended. METHOD: In a monocentric cross-sectional study, patients who had previously participated in a multi-modal pain therapy program lasting several weeks were asked about the follow-up recommendations of the interdisciplinary team of the Pain Management Clinic...
December 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/29201815/clinical-predictors-of-oro-esophageal-tube-feeding-success-in-brain-injury-patients-with-dysphagia
#9
Yoon Mok Chun, Min Ho Chun, Kyung Hee Do, Su Jin Choi
Objective: To identify possible clinical predictors of intermittent oro-esophageal (OE) tube feeding success, and evaluate the clinical factors associated with OE tube treatment. Methods: A total of 135 dysphagic patients were reviewed, who received OE tube treatment and were hospitalized in the department of rehabilitation medicine between January 2005 and December 2014. The 76 eligible cases enrolled were divided into two groups, based on the OE tube training success...
October 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29201367/services-aimed-at-achieving-desirable-clinical-outcomes-in-patients-with-chronic-kidney-disease-and-diabetes-mellitus-a-narrative-review
#10
REVIEW
Fergus William Gardiner, Ezekiel Uba Nwose, Phillip Taderera Bwititi, Judith Crockett, Lexin Wang
There is a large number of patients with chronic kidney disease (CKD), diabetes mellitus (DM), and hypertension (HT) but whether the targets on blood pressure (BP) control in patients with DM and/or CKD are met is not clear. This narrative review therefore investigated evidence on services aimed at achieving desirable clinical results in patients with CKD and DM, and HT in Australia. Literature pertaining to pathology diagnosis and management of these patients as well as the complexities in management were considered...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/29192691/patient-understanding-of-commonly-used-oral-medicine-terminology
#11
E Hayes, R Dua, E Yeung, K Fan
Introduction Communication within the doctor-patient relationship is complex due to a variety of reasons; a patient's understanding may not correspond with the clinician's vocabulary, resulting in misunderstanding, anxiety and ill-informed decision making. We investigated the understanding of terminology commonly used in oral and maxillofacial surgery and oral medicine clinics.Methods We investigated patients' understanding using a questionnaire-based study in the out-patient setting. Age, gender, first language and highest educational level were recorded...
December 1, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29189188/complementary-alternative-and-integrative-medicine-for-childhood-atopic-dermatitis
#12
Kam Lun Hon, Alexander K C Leung, Theresa N H Leung, Vivian Leeq
Backgroud: Atopic dermatitis (AD) is a chronic relapsing dermatosis associated with itch, sleep disturbance and poor quality of life. Treatment of AD includes the use of emollients, and topical and systemic immunomodulating agents. Many patients also use complementary and alternative medicine (CAM). OBJECTIVE: This article reviews the pathophysiology of AD and clinical trials involving various modalities of CAM in the treatment of AD. METHODS: A Medline/Pubmed search was conducted using Clinical Queries with the key terms "Chinese Medicine OR Complementary and Alternative medicine" AND "Eczema OR Atopic dermatitis"...
November 28, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29189136/the-role-of-biosimilars-in-patient-access-to-therapeutic-antibodies-for-immune-mediated-inflammatory-diseases
#13
Mary Ann Chapman, David Charles, Arturo Loaiza-Bonilla
BACKGROUND: Biosimilars have the potential to create competition, lower costs, and increase patient access to biological medications. However, biological medications are sensitive to their manufacturing processes and difficult to precisely characterize, leading to questions about substitution and interchangeability among products. METHODS: This article reviews the role of biosimilars in patient access to therapeutic antibodies. RESULTS: Although pathways for the approval of biosimilars have been developed, important issues remain unresolved...
November 29, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29187820/a-comprehensive-strategy-to-evaluate-compatible-stability-of-chinese-medicine-injection-and-infusion-solutions-based-on-chemical-analysis-and-bioactivity-assay
#14
Jian-Ping Li, Yang Liu, Jian-Ming Guo, Er-Xin Shang, Zhen-Hua Zhu, Kevin Y Zhu, Yu-Ping Tang, Bu-Chang Zhao, Zhi-Shu Tang, Jin-Ao Duan
Stability of traditional Chinese medicine injection (TCMI) is an important issue related with its clinical application. TCMI is composed of multi-components, therefore, when evaluating TCMI stability, several marker compounds cannot represent global components or biological activities of TCMI. Till now, when evaluating TCMI stability, method involving the global components or biological activities has not been reported. In this paper, we established a comprehensive strategy composed of three different methods to evaluate the chemical and biological stability of a typical TCMI, Danhong injection (DHI)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29180308/evidence-based-medicine-pandora-s-box-of-medical-and-surgical-treatment-of-endometriosis
#15
EDITORIAL
Philippe R Koninckx, Anastasia Ussia, Jorg Keckstein, Leila Adamian, Errico Zupi, Arnaud Wattiez, Victor Gomel
Evidence based medical and surgical therapies of endometriosis remain debated. A discussion of their limitations and pitfalls might help the clinician. Statistical evidence, including the RCT, is the probability that the means of 2 populations or therapies are different. Since the accuracy of the estimation of the mean increases with sample size, significance increases with sample size. Mathematical significance however may not indicate clinical usefulness since this requires some magnitude of the effect. In addition, results are valid only for the group investigated as defined in inclusion and exclusion criteria...
November 24, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29179708/comparing-doctors-legal-compliance-across-three-australian-states-for-decisions-whether-to-withhold-or-withdraw-life-sustaining-medical-treatment-does-different-law-lead-to-different-decisions
#16
Ben P White, Lindy Willmott, Colleen Cartwright, Malcolm Parker, Gail Williams, Juliet Davis
BACKGROUND: Law purports to regulate end-of-life care but its role in decision-making by doctors is not clear. This paper, which is part of a three-year study into the role of law in medical practice at the end of life, investigates whether law affects doctors' decision-making. In particular, it considers whether the fact that the law differs across Australia's three largest states - New South Wales (NSW), Victoria and Queensland - leads to doctors making different decisions about withholding and withdrawing life-sustaining treatment from adults who lack capacity...
November 28, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/29179283/-a-survey-of-willingness-about-genetic-counseling-and-tests-in-patients-of-epithelial-ovarian-cancer
#17
L Li, L Qiu, M Wu
Objective: To analyze patients' tendency towards genetics counseling and tests based on a prospective cohort study on hereditary ovarian cancer. Methods: From February 2017 to June 2017, among 220 cases of epithelial ovarian cancer in Peking Union Medical College Hospital, we collected epidemiological, pathological and tendency towards genetics counseling and tests via medical records and questionnaire.All patients would get education about hereditary ovarian cancer by pamphlets and WeChat.If they would receive further counseling, a face to face interview and tests will be given...
November 21, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29174928/efficacy-of-indigo-naturalis-in-a-multicenter-randomized-controlled-trial-of-patients-with-ulcerative-colitis
#18
Makoto Naganuma, Shinya Sugimoto, Keiichi Mitsuyama, Taku Kobayashi, Naoki Yoshimura, Hidehisa Ohi, Shinji Tanaka, Akira Andoh, Naoki Ohmiya, Keiichiro Saigusa, Takayuki Yamamoto, Yuichi Morohoshi, Hitoshi Ichikawa, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Kenji Watanabe, Shinta Mizuno, Wataru Suda, Masahira Hattori, Shinji Fukuda, Akiyoshi Hirayama, Takayuki Abe, Mamoru Watanabe, Toshifumi Hibi, Yasuo Suzuki, Takanori Kanai
BACKGROUND & AIMS: Indigo naturalis (IN) is a traditional Chinese medicine that contains ligands for the aryl hydrocarbon receptor and promotes regeneration of the mucosa, by inducing production of interleukin 22. IN might induce mucosal healing in patients with ulcerative colitis (UC). We performed a randomized controlled trial to investigate the safety and efficacy of IN in patients with UC. METHODS: We performed a multicenter, double-blind trial evaluated the safety of 86 patients in Japan with active UC (Mayo scores of 6 or more), enrolled from March 30 through December 27 2016...
November 22, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29174320/-prerequisite-for-hematopoietic-cellular-therapy-programs-to-set-up-chimeric-antigen-receptor-t-cell-therapy-car-t-cells-guidelines-from-the-french-speaking-society-of-bone-marrow-transplantation-and-cellular-therapy-sfgm-tc
#19
Ibrahim Yakoub-Agha, Christophe Ferrand, Yves Chalandon, Caroline Ballot, Cristina Castilla Llorente, Marina Deschamps, Jordan Gauthier, Myriam Labalette, Jérôme Larghero, Camille Maheux, Anne-Sophie Moreau, Pauline Varlet, Marie-Odile Pétillon, Marine Pinturaud, Marie Thérèse Rubio, Christian Chabannon
CAR T-cells are autologous or allogeneic human lymphocytes that are genetically engineered to express a chimeric antigen receptor targeting an antigen expressed on tumor cells such as CD19. CAR T-cells represent a new class of medicinal products, and belong to the broad category of Advanced Therapy Medicinal Products (ATMPs), as defined by EC Regulation 2007-1394. Specifically, they are categorized as gene therapy medicinal products. Although CAR T-cells are cellular therapies, the organization for manufacturing and delivery is far different from the one used to deliver hematopoietic cell grafts, for different reasons including their classification as medicinal products...
November 23, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29171219/-study-on-attenuating-hepatotoxicity-of-tripterygium-wilfordii-through-compatibility-of-traditional-chinese-medicine-compound
#20
Ying Liu, Qing-Xiang Zhong, Hui-Hui Qiu, Gang Wang, Cheng-Cheng Wang, Liang Feng, Xiao-Bin Jia
With the deepening of the study of toxicology of traditional Chinese medicine, the mechanism of hepatotoxicity caused by Tripterygium wilfordii has been gradually revealed. As one of the characteristics of traditional Chinese medicine, Chinese medicine compatibility show its more reasonable and scientific effect in terms of reducing toxicity. In this paper, the author summarizes the research on the basis and mechanism of toxic substances in T. wilfordii, and sum up the compatibility of traditional Chinese medicine (preparation) to reduce its role of hepatotoxicity, so as to provide reference for the rationality and safety in clinical application of T...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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