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https://www.readbyqxmd.com/read/29455762/bvs-rdn-iabp-the-afghanistan-of-interventional-cardiology-trials
#1
EDITORIAL
Sundeep Mishra
In the field of medicine and cardiology newer therapy and devices have been launched with a huge promise and a lot of hype. Unfortunately, over the course of time, a good many of them like biovascular scaffold, renal denervation and intra-aortic balloon pump have failed to live up to their initial promise so much so that some of them have been withdrawn. The reason for this downfall may be multifold from incomplete understanding of the patho-physiology of disease, incomplete understanding of mechanism of action of the therapy, in-appropriate application in clinical practice, in-efficient therapy development related to flawed trial design, regulatory impediments placed on the trials or deficits in application of scientific techniques...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29453677/changes-in-medicine-prescription-following-a-medication-review-in-older-high-risk-patients-with-polypharmacy
#2
Marian Z M Hurmuz, Sarah I M Janus, Jeannette G van Manen
Background The more (inappropriate) drugs a patient uses, the higher the risk of drug related problems. To reduce these risks, medication reviews can be performed. Objective To report changes in the prescribed number of (potentially inappropriate) drugs before and after performing a medication review in high-risk polypharmacy patients. A secondary objective was to study reasons for continuing potentially inappropriate drugs (PIDs). Setting Dutch community pharmacy and general medical practice. Methods A retrospective longitudinal intervention study with a pre-test/post-test design and follow-up of 1 week and 3 months was performed...
February 17, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29451516/-evidence-based-medicine-vs-personalized-medicine
#3
Lucio Capurso
Evidence-based medicine (EBM) and personalized medicine (PM) are driven by two diverse modes of reasoning about «evidence making». EBM has been criticized since his quality mark has been misappropriated by vested interests, the benefits statistically significant may be marginal in clinical practice, rigid rules and technology may produce care that is management driven rather than patient centered. On the contrary PM (or "precision medicine") refers to the tailoring of medical treatment to the specific characteristics of each patient involving the ability to classify individuals into subpopulations that are uniquely susceptible to a specific treatment, sparing expense and side effects and is derived from doubts on the results of subgroup analyses and on non responders in clinical trials typical of EBM...
January 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29445542/assessing-the-sleeping-habits-of-patients-in-a-sleep-disorder-centre-a-review-of-sleep-diary-accuracy
#4
Geoffrey Lawrence, Rexford Muza
Background: Excessive daytime sleepiness (EDS) is a complaint common to many aspects of medicine. There are primary and secondary causes for EDS, with secondary causes including a large number of common conditions. Primary causes, such as narcolepsy, are much rarer. When assessing for primary hypersomnia, restricted or fragmented sleep must be ruled out. This process involves assessment of sleeping habits using a sleep diary and/or actigraphy. Clinicians are suspicious of the accuracy with which patients use the former...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29442539/platelets-in-wound-healing-and-regenerative-medicine
#5
Julia Etulain
Although platelets are widely recognized as having a critical role in primary hemostasis and thrombosis, increasing experimental and clinical evidence identifies these enucleated cells as relevant modulators of other physiopathological processes including inflammation and tissue regeneration. These phenomena are mediated through the release of growth factors, cytokines, and extracellular matrix modulators that sequentially promote (i) revascularization of damaged tissue through the induction of migration, proliferation, differentiation, and stabilization of endothelial cells in new blood vessels; (ii) restoration of damaged connective tissue through migration, proliferation, and activation of fibroblasts; and (iii) proliferation and differentiation of mesenchymal stem cells into tissue-specific cell types...
February 14, 2018: Platelets
https://www.readbyqxmd.com/read/29441421/diagnostic-error-in-stroke-reasons-and-proposed-solutions
#6
REVIEW
Ekaterina Bakradze, Ava L Liberman
PURPOSE OF REVIEW: We discuss the frequency of stroke misdiagnosis and identify subgroups of stroke at high risk for specific diagnostic errors. In addition, we review common reasons for misdiagnosis and propose solutions to decrease error. RECENT FINDINGS: According to a recent report by the National Academy of Medicine, most people in the USA are likely to experience a diagnostic error during their lifetimes. Nearly half of such errors result in serious disability and death...
February 13, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29439086/using-photography-to-enhance-gp-trainees-reflective-practice-and-professional-development
#7
Rutherford, Emer Forde, Jacqueline Priego-Hernandez, Aurelia Butcher, Clare Wedderburn
The capacity and the commitment to reflect are integral to the practice of medicine and are core components of most general practitioners (GP) training programmes. Teaching through the humanities is a growing area within medical education, but one which is often considered a voluntary 'add-on' for the interested doctor. This article describes an evaluation of a highly innovative pedagogical project which used photography as a means to enhance GP trainees' reflective capacity, self-awareness and professional development...
February 8, 2018: Medical Humanities
https://www.readbyqxmd.com/read/29433139/-a-health-promotion-campaign-to-improve-flu-vaccination-adherence-among-medical-residents-in-an-italian-teaching-hospital
#8
Andrea Barbara, Andrea Poscia, Concetta De Meo, Chiara De Waure, Vincenza Anzelmo, Paolo Emilio Santoro, Antonio Maruccia, Gabriele Giubbini, Alice Corsaro, Filippo Berloco, Gianfranco Damiani, Walter Ricciardi, Patrizia Laurenti
INTRODUCTION: In Italy annual flu vaccination for health care workers is recommended but coverage is usually unsatisfying. The compliance is even worse among medical residents (MRs) both in literature, both in our experience: in the flu season 2014/ 15 only 0.6% of MRs enrolled at the Università Cattolica del Sacro Cuore (UCSC) were vaccinated. For this reason, during the influenza season 2015/16, the Institute of Public Health of the UCSC, in collaboration with the Health Management of the "Agostino Gemelli" Teaching Hospital (FPG) and with the directive board of the Medical Specialization Schools (SSM) present at the University has tested several strategies to improve awareness and adherence to flu vaccination campaign by its staff...
September 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/29427552/quality-and-future-of-clinical-laboratories-the-vico-s-whole-cyclical-theory-of-the-recurring-cycles
#9
Mario Plebani
In the last few decades, laboratory medicine has undergone monumental changes, and laboratory technology, which has made enormous advances, now has new clinical applications thanks to the identification of a growing number of biomarkers and risk factors conducive to the promotion of predictive and preventive interventions that have enhanced the role of laboratory medicine in health care delivering. However, the paradigm shift in the past 50 years has led to a gap between laboratory and clinic, with an increased risk of inappropriateness in test request and interpretation, as well as the consolidation of analytical work in focused factories and megastructurers oriented only toward achieving greater volumes, decreasing cost per test and generating a vision of laboratory services as simple commodities...
February 10, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29427181/toxic-alcohol-diagnosis-and-management-an-emergency-medicine-review
#10
REVIEW
Patrick Chow Yuen Ng, Brit J Long, William Tyler Davis, Daniel J Sessions, Alex Koyfman
Toxic alcohols are a group of substances containing a hydroxyl group not meant to be ingested. They are the cause of a significant number of accidental and non-accidental exposures. Toxic alcohol poisoning can be associated with a significant degree of morbidity and mortality if not promptly recognized and treated. This review describes the clinical presentation and an approach to the recognition and management for toxic alcohol poisoning. Toxic alcohols classically refer to a group of alcohols not meant for ingestion...
February 9, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29426601/from-quality-markers-to-data-mining-and-intelligence-assessment-a-smart-quality-evaluation-strategy-for-traditional-chinese-medicine-based-on-quality-markers
#11
Gang Bai, Tiejun Zhang, Yuanyuan Hou, Guoyu Ding, Min Jiang, Guoan Luo
BACKGROUND: The quality of traditional Chinese medicine (TCM) forms the foundation of its clinical efficacy. The standardization of TCM is the most important task of TCM modernization. In recent years, there has been great progress in the quality control of TCM. However, there are still many issues related to the current quality standards, and it is difficult to objectively evaluate and effectively control the quality of TCM. PURPOSE: To face these challenge, we summarized the current quality marker (Q-marker) research based on its characteristics and benefits, and proposed a reasonable and intelligentized quality evaluation strategy for the development and application of Q-markers...
January 31, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29425355/an-initial-report-of-sleep-disorders-in-women-in-the-u-s-military
#12
Dale C Capener, Matthew S Brock, Shana L Hansen, Panagiotis Matsangas, Vincent Mysliwiec
Introduction: Sleep disorders are increasingly recognized in active duty service members (ADSM). While there are multiple studies in male ADSM, there are limited data regarding sleep disorders in women in the military. The purpose of this study was to characterize sleep disorders in female ADSM referred for clinical evaluation to provide a better understanding of this unique population. Materials and Methods: We conducted a retrospective review of female ADSM who underwent a sleep medicine evaluation and an attended polysomnogram (PSG)...
February 7, 2018: Military Medicine
https://www.readbyqxmd.com/read/29423824/attitudes-of-irish-patients-with-chronic-pain-towards-medicinal-cannabis
#13
Ciaran Rochford, Deirdre Edgeworth, Mohammad Hashim, Dominic Harmon
BACKGROUND: Medicinal cannabis use is topical in the media in Ireland. A recent Health Products Regulatory Authority review, however, has recommended against its use for patients with chronic pain. This is despite evidence for its effectiveness in this patient's cohort and the inadequate pain management of these patients. AIM: The aim of this study was to evaluate the attitudes of Irish patients with chronic pain towards medicinal cannabis. METHODS: After institutional ethics committee approval, a 12-item questionnaire (excluding demographics) was randomly assigned to patients attending a chronic pain clinic (University Hospital Limerick)...
February 8, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29423618/organotypic-models-of-lung-cancer
#14
Anna Pomerenke
Human lung cancer is one of the leading causes of death worldwide, with nearly 2 million of new cases diagnosed each year, often too late for a successful therapeutic intervention. In this chapter, organotypic models of lung cancer will be reviewed. Ex vivo tissue explants, spheroids, organoids, and novel bioengineering approaches are currently being used to study human lung cancer. Although there is no ideal method that will fully recapitulate the complex human lung architecture, the three-dimensional (3D) organotypic models described here represent a major advance from classical two-dimensional (2D) tissue culture models...
February 9, 2018: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/29422773/what-determines-medical-students-career-preference-for-general-practice-residency-training-a-multicenter-survey-in-japan
#15
Kenya Ie, Akiko Murata, Masao Tahara, Manabu Komiyama, Shuhei Ichikawa, Yousuke C Takemura, Hirotaka Onishi
Background: Few studies have systematically explored factors affecting medical students' general practice career choice. We conducted a nationwide multicenter survey (Japan MEdical Career of Students: JMECS) to examine factors associated with students' general practice career aspirations in Japan, where it has been decided that general practice will be officially acknowledged as a new discipline. Methods: From April to December 2015, we distributed a 21-item questionnaire to final year medical students in 17 medical schools...
2018: Asia Pacific Family Medicine
https://www.readbyqxmd.com/read/29416859/applying-realistic-medicine-to-intrathecal-opioid-utilisation-in-scotland-do-we-have-a-standardised-approach
#16
Robert Hart, Gordon Burns, Susan Smith
Intrathecal opioids (ITOs) are commonly administered as part of a multimodal anaesthetic strategy for a variety of surgical procedures. The evolution of laparoscopic surgical techniques has seen the popularity of ITOs increase as they are effective, well tolerated and lack the cardiovascular side effects associated with epidural infusions. The risk of delayed respiratory depression remains a concern; therefore, high-quality post-operative monitoring is vital. The evidence regarding the practicalities of ITO administration such as opioid dose, type, side effect prevalence and ideal post-operative care arrangements are sparse...
February 2018: British Journal of Pain
https://www.readbyqxmd.com/read/29412118/antibody-administration-for-bone-tissue-engineering-a-systematic-review
#17
Sepanta Hosseinpour, Maryam Rezai Rad, Arash Khojasteh, Homa Zadeh
BACKGROUND: Currently, antibodies are progressively applied in medicine for different purposes from diagnosis to treatments. Over twenty monoclonal antibodies utilized for many therapeutic reasons from therapy of cancers, immune disorders, and osteoporosis to localized bony defects. In addition, therapeutic antibodies represented various findings in bone tissue engineering. OBJECTIVES: The current study aims to systematically review the available literature on antibody assisted bone regeneration in animal models...
February 6, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29408407/antimicrobial-susceptibility-survey-on-bacterial-agents-of-canine-and-feline-urinary-tract-infections-weight-of-the-empirical-treatment
#18
Elisa Rampacci, Marco Bottinelli, Valentina Stefanetti, Doreene R Hyatt, Elisa Sgariglia, Mauro Coletti, Fabrizio Passamonti
OBJECTIVES: This work characterizes the antimicrobial susceptibility of uropathogens isolated from empirically treated dogs and cats. Within-household transmission of uropathogens can involve humans and companion animals. Knowledge on the prevalence and susceptibility pattern of isolates from canine and feline urine samples and the impact of prior antimicrobial treatment is important to prevent the dissemination of antimicrobial resistance. METHODS: A retrospective study was conducted selecting antibiotically treated companion animals...
February 3, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29405603/safety-and-observations-from-a-placebo-controlled-crossover-study-to-assess-use-of-autologous-umbilical-cord-blood-stem-cells-to-improve-symptoms-in-children-with-autism
#19
Michael Chez, Christopher Lepage, Carol Parise, Ashley Dang-Chu, Andrea Hankins, Michael Carroll
The aim of this exploratory study was to assess the safety and clinical effects of autologous umbilical cord blood (AUCB) infusion in children with idiopathic autism spectrum disorder (ASD). Twenty-nine children 2 to 6 years of age with a confirmed diagnosis of ASD participated in this randomized, blinded, placebo-controlled, crossover trial. Participants were randomized to receive AUCB or placebo, evaluated at baseline, 12, and 24 weeks, received the opposite infusion, then re-evaluated at the same time points...
February 6, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29405077/barriers-to-implementation-of-a-pelvic-examination-among-family-doctors-in-primary-care-clinics
#20
Nassar Saleh, Mousa Abu-Gariba, Ilan Yehoshua, Roni Peleg
OBJECTIVE: Although the pelvic examination of female patients should be an integral part of the physical examination in family medicine there are many barriers to the conduct of this intimate examination by family doctors. THE OBJECTIVE: an assessment of the attitudes and barriers reported by family doctors on conducting a pelvic examination. METHODS: An anonymous, self-administered questionnaire. RESULTS: Two hundred thirty doctors participated in the study, of who 157 were males (68...
February 6, 2018: Postgraduate Medicine
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