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https://www.readbyqxmd.com/read/29475067/transcriptional-profiling-of-male-cd-1-mouse-lungs-and-harderian-glands-supports-the-involvement-of-calcium-signaling-in-acrylamide-induced-tumors
#1
Nikolai L Chepelev, Rémi Gagné, Timothy Maynor, Byron Kuo, Cheryl A Hobbs, Leslie Recio, Carole L Yauk
Acrylamide (AA) exposure causes increased incidence of forestomach, lung, and Harderian gland tumors in male mice. One hypothesized mode of action (MOA) for AA-carcinogenicity includes genotoxicity/mutagenicity as a key event, possibly resulting from AA metabolism to the direct genotoxic metabolite glycidamide. Alternatively, altered calcium signaling (CS) has been proposed as a central key event in the MOA. To examine the plausibility of these proposed MOAs, RNA-sequencing was performed on tumor target tissues: Harderian glands (the most sensitive tumor target tissue in the rodent 2-year cancer bioassay) and lungs of AA-exposed male CD-1 mice...
February 20, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29474517/cost-function-network-based-design-of-protein-protein-interactions-predicting-changes-in-binding-affinity
#2
Clément Viricel, Simon de Givry, Thomas Schiex, Sophie Barbe
Motivation: Accurate and economic methods to predict change in protein binding free energy upon mutation are imperative to accelerate the design of proteins for a wide range of applications. Free energy is defined by enthalpic and entropic contributions. Following the recent progresses of Artificial Intelligence-based algorithms for guaranteed NP-hard energy optimization and partition function computation, it becomes possible to quickly compute minimum energy conformations and to reliably estimate the entropic contribution of side-chains in the change of free energy of large protein interfaces...
February 20, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29474312/benchmarking-implications-analysis-of-medicare-accountable-care-organizations-spending-level-and-quality-of-care
#3
Young-Rock Hong, Frederick Kates, Soon Ju Song, Nayoung Lee, R Paul Duncan, Nicole M Marlow
Early evidence has shown that Accountable Care Organizations (ACOs) have achieved some success in improving the quality of care and reducing Medicare costs. However, it has been argued that the ACO rewarding model may disproportionately affect relatively low-spending (LS; considered as efficient) organizations that have fewer options to cut unnecessary services compared with high-spending (HS; inefficient) organizations. We conducted a cross-sectional retrospective study to compare ACO financial and quality of care performance between HS-ACO and LS-ACO...
February 16, 2018: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/29474243/anticipating-the-impact-of-human-papillomavirus-vaccination-on-us-cervical-cancer-prevention-strategies
#4
L Stewart Massad
Cervical cancer prevention guidelines are benchmarked to risk of cervical precancer. In younger age cohorts, vaccination against high-risk types of human papillomavirus (HPV) has reduced HPV 16/18 prevalence and cervical intraepithelial neoplasia. Lower prevalence of precancer will impair the sensitivity of cytology and colposcopy, but negative predictive value will rise. Training and skills maintenance will become more difficult as abnormalities become less common. Primary screening with HPV assays will become more attractive but will require HPV genotyping as most positive HPV tests will reflect non-16/18 infections with lower oncogenicity...
February 23, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29474189/characteristic-of-ebt-xd-and-ebt3-radiochromic-film-dosimetry-for-photon-and-proton-beams
#5
Suphalak Khachonkham, Ralf Dreindl, Gerd Heilemann, Wolfgang Lechner, Hermann Fuchs, Hugo Palmans, Dietmar Georg, Peter Kuess
Recently, a new type of radiochromic film, the EBT XD film, has been introduced for high dose radiotherapy. The EBT XD film contains the same structure as the EBT3 film but has a slightly different composition and a thinner active layer. This study benchmarks the EBT XD against EBT3 film for 6 MV and 10 MV photon beams, as well as for 97.4 MeV and 148.2 MeV proton beams and 15¬ 100 kV x-rays. Dosimetric and film reading characteristics, such as post irradiation darkening, film orientation effect, lateral response artifact (LRA), film sensitivity, energy and beam quality dependency were investigated...
February 23, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29473750/excited-states-of-methylene-polyenes-and-ozone-from-heat-bath-configuration-interaction
#6
Alan Derlin Chien, Adam A Holmes, Matthew Otten, Cyrus J Umrigar, Sandeep Sharma, Paul M Zimmerman
The electronically excited states of methylene (CH2 ), ethylene (C2 H4 ), butadiene (C4 H6 ), hexatriene (C6 H8 ), and ozone (O3 ) have long proven challenging due to their complex mixtures of static and dynamic correlations. Semistochastic heat-bath configuration interaction (SHCI), which efficiently and systematically approaches the full configuration interaction (FCI) limit, is used to provide close approximations to the FCI energies in these systems. This article presents the largest FCI-level calculation to date - on hexatriene using a polarized double-zeta basis (ANO-L-pVDZ), which gives rise to a Hilbert space containing more than 1038 determinants...
February 23, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29473742/testing-semiempirical-qm-methods-on-a-data-set-of-interaction-energies-mapping-repulsive-contacts-in-organic-molecules
#7
Vijay M Miriyala, Jan Řezáč
Semiempirical QM methods with corrections for non-covalent interactions provide a favorable combination of accuracy and computational efficiency what makes them useful tool for a study of large molecular systems. It was, however, noted that the accuracy of these method deteriorates at intermolecular distances shorter than equilibrium. In this work, we explore this issue systematically using a newly developed data set of benchmark interaction energies named R160x6. This data set maps repulsive contacts in organic molecules, and it consists of 160 model complexes for which six points along the dissociation curve are provided...
February 23, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29473451/a-nationwide-cross-sectional-survey-of-pharmacy-students-on-pharmacogenetic-testing-in-the-netherlands
#8
Paul Cd Bank, Jesse J Swen, Henk-Jan Guchelaar
AIM: To benchmark knowledge and attitude of pharmacy students toward pharmacogenetics (PGx) and PGx testing and compare the results with practicing colleagues. METHODS: All pharmacy students in The Netherlands were invited to participate in a web-based survey consisting of 28 questions. Out of the 824 invited students, 148 individuals (18.0%) completed the questionnaire. All responders believed in the concept of PGx and had high expectations toward PGx. The majority (96...
February 23, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29473212/demographic-psychosocial-and-behavioral-associations-with-cancer-screening-among-a-homeless-population
#9
Lovoria B Williams, Amber McCall, Stephen W Looney, Thomas Joshua, Martha S Tingen
BACKGROUND: Although cancer incidence and mortality is declining, cancer remains among the leading causes of death in the United States. Research shows that cancer morbidity and mortality can be reduced by early detection. Yet, both cancer risks and screening behavior remain understudied in the homeless population. METHODS: Researchers conducted a cross-sectional survey of homeless individuals (n = 201). The analysis describes the demographic, psychosocial, and behavioral associations with cancer screenings and knowledge of the lung cancer screening recommendation...
February 23, 2018: Public Health Nursing
https://www.readbyqxmd.com/read/29473154/polyunsaturated-fatty-acids-and-risk-of-melanoma-a-mendelian-randomisation-analysis
#10
Upekha E Liyanage, Matthew H Law, Jue Sheng Ong, Anne E Cust, Graham J Mann, Sarah V Ward, Puya Gharahkhani, Mark M Iles, Stuart MacGregor
Melanoma is the deadliest form of skin cancer, mainly affecting populations of European ancestry. Some observational studies suggest that particular diets reduce melanoma risk - putatively through an increase in polyunsaturated fatty acid (PUFA) consumption. However, interpretation of these observational findings is difficult due to residual confounding or reverse causality. To date, a randomised controlled trial has not been carried out to examine the relationship between PUFAs and melanoma. Hence, we performed a Mendelian randomisation (MR) study to evaluate the link between PUFAs and melanoma...
February 22, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29472600/panda-protein-function-prediction-using-domain-architecture-and-affinity-propagation
#11
Zheng Wang, Chenguang Zhao, Yiheng Wang, Zheng Sun, Nan Wang
We developed PANDA (Propagation of Affinity and Domain Architecture) to predict protein functions in the format of Gene Ontology (GO) terms. PANDA at first executes profile-profile alignment algorithm to search against PfamA, KOG, COG, and SwissProt databases, and then launches PSI-BLAST against UniProt for homologue search. PANDA integrates a domain architecture inference algorithm based on the Bayesian statistics that calculates the probability of having a GO term. All the candidate GO terms are pooled and filtered based on Z-score...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29472075/a-novel-high-resolution-2d-silicon-array-detector-for-small-field-dosimetry-with-fff-photon-beams
#12
G Biasi, M Petasecca, S Guatelli, N Hardcastle, M Carolan, V Perevertaylo, T Kron, A B Rosenfeld
PURPOSE: Flattening filter free (FFF) beams are increasingly being considered for stereotactic radiotherapy (SRT). For the first time, the performance of a monolithic silicon array detector under 6 and 10 MV FFF beams was evaluated. The dosimeter, named "Octa" and designed by the Centre for Medical Radiation Physics (CMRP), was tested also under flattened beams for comparison. METHODS: Output factors (OFs), percentage depth-dose (PDD), dose profiles (DPs) and dose per pulse (DPP) dependence were investigated...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29471657/time-dependent-density-functional-theory-description-of-total-photoabsorption-cross-sections
#13
Bruno Nunes Cabral Tenorio, Marco Antonio Chaer Nascimento, Alexandre Braga Rocha
The time-dependent version of the density functional theory (TDDFT) has been used to calculate the total photoabsorption cross section of a number of molecules, namely, benzene, pyridine, furan, pyrrole, thiophene, phenol, naphthalene, and anthracene. The discrete electronic pseudo-spectra, obtained in a L2 basis set calculation were used in an analytic continuation procedure to obtain the photoabsorption cross sections. The ammonia molecule was chosen as a model system to compare the results obtained with TDDFT to those obtained with the linear response coupled cluster approach in order to make a link with our previous work and establish benchmarks...
February 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29471633/benchmarks-and-breakthroughs
#14
Michael J Sailor
No abstract text is available yet for this article.
February 23, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29471468/working-conditions-and-stress-in-the-english-education-system
#15
J M Ravalier, J Walsh
Background: The UK education sector has among the highest level of stress sickness absence of all occupations. However, investigations of psychosocial working conditions which contribute to stress, including behaviour of students and parents, has not been conducted. Aims: To investigate the psychosocial working conditions and prevalence of negative parental and student behaviour in a large sample of school teachers and college lecturers based in England. In addition, to assess the influence of working conditions, student behaviour and parental behaviour on perceived stress...
February 17, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29471454/the-impact-of-using-different-reference-populations-on-measurement-of-breast-cancer-related-cognitive-impairment-rates
#16
Jonathan D Clapp, George Luta, Brent J Small, Tim A Ahles, James C Root, Deena Graham, Arti Hurria, Paul B Jacobsen, Heather Jim, Brenna C McDonald, Robert A Stern, Andrew J Saykin, Jeanne S Mandelblatt
Objective: To evaluate how use of different reference populations affects estimates of breast cancer-related cognitive impairment rates. Methods: Patients aged ≥60 years with stage 0-3 breast cancer (n = 371) and matched non-cancer controls (n = 370) completed 13 neuropsychological tests prior to systemic therapy or at enrollment (controls). The tests captured three domains: attention, processing speed and executive function; learning and memory; and visual-spatial function...
February 17, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29470846/benchmarking-the-question-persuade-refer-program-against-evaluations-of-established-suicide-prevention-gatekeeper-trainings
#17
Renee Brown Hangartner, Christine M Wienke Totura, Christa D Labouliere, Kim Gryglewicz, Marc S Karver
Gatekeeper training is a common approach for aiding suicidal youth. This study utilizes comparative effectiveness "benchmarks" from established programs to evaluate the Question, Persuade, Refer (QPR) program. The QPR program was implemented with adults (N = 2,389) working in youth-serving community agencies. Questionnaires assessed suicide prevention knowledge, attitudes, subjective norms, perceived behavioral control, and behaviors. Consistent with benchmarked studies, participants in QPR demonstrated knowledge and suicide prevention behavior gains compared with control groups...
February 22, 2018: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/29470171/hyperspectral-image-classification-with-markov-random-fields-and-a-convolutional-neural-network
#18
Xiangyong Cao, Feng Zhou, Lin Xu, Deyu Meng, Zongben Xu, John Paisley
This paper presents a new supervised classification algorithm for remotely sensed hyperspectral image (HSI) which integrates spectral and spatial information in a unified Bayesian framework. First, we formulate the HSI classification problem from a Bayesian perspective. Then, we adopt a convolutional neural network (CNN) to learn the posterior class distributions using a patch-wise training strategy to better use the spatial information. Next, spatial information is further considered by placing a spatial smoothness prior on the labels...
May 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29469909/composition-driven-shape-evolution-to-cu-rich-ptcu-octahedral-alloy-nanocrystals-as-superior-bifunctional-catalysts-for-methanol-oxidation-and-oxygen-reduction-reaction
#19
Chaozhong Li, Taiyang Liu, Ting He, Bing Ni, Qiang Yuan, Xun Wang
Synergetic effects between Pt and a cheap metal, downshift of the d-band center of Pt and the shape can boost the catalytic performance of Pt-based nanocrystals. Therefore, tailoring the shape and composition within the nanoscale is the key to designing a robust electrocatalyst in electrochemical energy conversion. Here, Cu-rich PtCu octahedral alloys achieved by a composition-driven shape evolution route have been used as outstanding bifunctional electrocatalysts for both methanol oxidation (MOR) and oxygen reduction reaction (ORR) in an acid medium...
February 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29469812/dimethyl-methylphosphonate-adsorption-and-decomposition-on-moo-sub-2-sub-as-studied-by-ambient-pressure-x-ray-photoelectron-spectroscopy-and-dft-calculations
#20
Ashley Rose Head, Roman Tsyshevsky, Lena Trotochaud, Yi Yu, Osman Karslıoğlu, Bryan Eichhorn, Maija M Kuklja, Hendrik Bluhm
Organophosphonates range in their toxicity and are used as pesticides, herbicides, and chemical warfare agents (CWAs). Few laboratories are equipped to handle the most toxic molecules, thus simulants, such as dimethyl methylphosphonate (DMMP), are used as a first step in studying adsorption and reactivity on materials. Benchmarked by combined experimental and theoretical studies of simulants, calculations offer an opportunity to understand how molecular interactions with a surface changes upon using a CWA. However, most calculations of DMMP and CWAs on surfaces are limited to adsorption studies on clusters of atoms, which may differ markedly from the behavior on bulk solid-state materials with extended surfaces...
February 22, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
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