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https://www.readbyqxmd.com/read/28821197/regional-variability-in-percentage-of-breast-cancers-reported-as-positive-for-her2-in-california-implications-of-patient-demographics-on-laboratory-benchmarks
#1
Chieh-Yu Lin, Eugene E Carneal, Daphne Y Lichtensztajn, Scarlett L Gomez, Christina A Clarke, Kristin C Jensen, Allison W Kurian, Kimberly H Allison
Objectives: The expected regional variability in percent human epidermal growth factor receptor 2 (HER2)-positive breast cancers is not currently clear. Methods: Data from the 2006 to 2011 California Cancer Registry were examined by county and health service area. The influence of demographic and pathologic features was used in a multivariable logistic regression model to compare expected with observed HER2-positive percentages by region. Results: There was significant geographic variation by California counties (11...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28821073/a-new-quality-index-for-benchmarking-of-different-cellulose-nanofibrils
#2
Johanna Desmaisons, Elisa Boutonnet, Martine Rueff, Alain Dufresne, Julien Bras
From a single plant source, a wide range of mechanically-deconstructed cellulose nanomaterials can be obtained due to the large number of possible combinations of pre-treatments, mechanical disintegration process, and post-treatments. It leads to the existence of a variety of cellulose nanofibrils with different shapes, morphologies, and properties on the market. The resulting material is actually a complex mixture of nanoscale particles, microfibrillated fibers, and residual fibers on the millimeter scale...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820588/exploiting-and-understanding-the-selectivity-in-nhc-based-ru-metathesis-catalysts-for-the-ethenolysis-of-cyclic-olefins-to-%C3%AE-%C3%AF-dienes
#3
Pascal S Engl, Celine B Santiago, Christopher P Gordon, Wei-Chih Liao, Alexey Fedorov, Christophe Copéret, Matthew S Sigman, Antonio Togni
A library of 29 homologous Ru-based olefin metathesis catalysts has been tested for ethenolysis of cyclic olefins towards the goal of selectively forming α,ω-diene using cis-cyclooctene as a prototypical substrate. Dissymmetry at the N-heterocyclic carbene (NHC) ligand was identified as a key parameter for controlling the selectivity. The best-performing catalyst bearing an N-CF3 group significantly outperformed the benchmark second-generation Grubbs catalyst in the ethenolysis of cis-cycloctene. Application of this optimal catalyst to the ethenolysis of various norbornenes allows the efficient synthesis of valuable diene intermediates in good yields...
August 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28820540/endoscopic-port-access-surgery-for-late-orthotopic-cardiac-transplantation-atrioventricular-valve-disease
#4
Johan van der Merwe, Filip Casselman, Bernard Stockman, Yvette Vermeulen, Ivan Degrieck, Frank Van Praet
BACKGROUND: The study aim was to present details of the perioperative and long-term outcomes of redo-endoscopic port access surgery (REPAS) for late atrioventricular valve disease (AVVD) in orthotopic cardiac transplant (OCT) patients. METHODS: Between February 2004 and October 2015, REPAS was performed for late AVVD in seven consecutive OCT patients (mean age 57.9 ± 17.2 years; EuroSCORE II 21.2 ± 14.7%) at the authors' institution. The mean OCT-REPAS time interval was 7...
March 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28820230/are-you-ready-crisis-leadership-in-a-hyper-vuca-environment
#5
Khaldoon H Alkhaldi, Meredith L Austin, Boris A Cura, Darrell Dantzler, Leslie Holland, David L Maples, Jamie C Quarrelles, Robert K Weinkle, Leonard J Marcus
The current hyper-volatile, -uncertain, -complex, and -ambiguous (VUCA) threat environment demands a more cohesive support structure for crisis leaders who may be faced with crises of increasing magnitude and frequency and, in some instances, multiple crisis events simultaneously. The project team investigates the perceptions of crisis leaders regarding establishing a crisis leader advisor position for crisis leaders to benefit from their experience while prosecuting crisis response activities. The team linked hyper-VUCA crises, crisis response frameworks, meta-leadership, crisis leader attributes, and advisor attributes...
March 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/28819770/total-suspended-solids-effects-on-freshwater-lake-biota-other-than-fish
#6
REVIEW
Peter M Chapman, April Hayward, John Faithful
Protective benchmarks for the effects of total suspended solids (TSS) on freshwater aquatic biota primarily focus on fish; whether these benchmarks will also protect their prey or co-existing lower trophic level aquatic biota was uncertain. We conducted an extensive literature review of TSS effects on those organisms comprising the food webs upon which fish living in lakes depend: phytoplankton, zooplankton, periphyton, and benthic invertebrates. The available literature indicates that TSS benchmarks that protect sensitive life stages of lake fish will also protect their supporting food webs; in other words, the function of lake aquatic communities will be protected and maintained...
August 17, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28818800/the-step-wise-framework-to-design-a-chromatography-based-hydrophobicity-assay-for-viral-particles
#7
Sarah A Johnson, Alison Walsh, Matthew R Brown, Scott C Lute, David J Roush, Michael S Burnham, Kurt A Brorson
A high-salt, hydrophobic interaction chromatography (HIC) method was developed to measure the relative hydrophobicity of a diverse set of solutes. Through the careful control of buffer pH and salt concentration, this assay was then used to ascertain for the first time the relative hydrophobicity values of three different bacteriophage, four mammalian viruses, and a range of biotech medicinal proteins as benchmarked to protein standards previously characterized for hydrophobicity.
August 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28818609/multicenter-comparison-of-22c3-pharmdx-agilent-and-sp263-ventana-assays-to-test-pd-l1-expression-for-nsclc-patients-to-be-treated-with-immune-checkpoint-inhibitors
#8
Antonio Marchetti, Massimo Barberis, Renato Franco, Graziano De Luca, Maria Vittoria Pace, Stefania Staibano, Marco Volante, Fiamma Buttitta, Elena Guerini-Rocco, Luisella Righi, Tommaso D'antuono, Giorgio V Scagliotti, Carmine Pinto, Gaetano De Rosa, Mauro Papotti
INTRODUCTION: Among the several agents targeting the programmed cell death 1 (PD-1) pathway, pembrolizumab is currently the only one approved for the treatment of non-small cell lung cancer patients in association with a companion diagnostic assay, the anti-programmed cell death ligand 1 (PD-L1) immunohistochemical (IHC) 22C3 PharmDx (Agilent) using the Dako Autostainer. However, the Dako platform is not present in each pathology department and this technical limitation is a major problem for the diffusion of the PD-L1 IHC predictive test for pembrolizumab...
August 14, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28818512/ploc-meuk-predict-subcellular-localization-of-multi-label-eukaryotic-proteins-by-extracting-the-key-go-information-into-general-pseaac
#9
Xiang Cheng, Xuan Xiao, Kuo-Chen Chou
Many efforts have been made in predicting the subcellular localization of eukaryotic proteins, but most of the existing methods have the following two limitations: (1) their coverage scope is less than ten locations and hence many organelles in an eukaryotic cell cannot be covered, and (2) they can only be used to deal with single-label systems in which each of the constituent proteins has one and only one location. Actually, proteins with multiple locations are particularly interesting since they may have some exceptional functions very important for in-depth understanding the biological process in a cell and for selecting drug target as well...
August 14, 2017: Genomics
https://www.readbyqxmd.com/read/28818042/coreference-annotation-and-resolution-in-the-colorado-richly-annotated-full-text-craft-corpus-of-biomedical-journal-articles
#10
K Bretonnel Cohen, Arrick Lanfranchi, Miji Joo-Young Choi, Michael Bada, William A Baumgartner, Natalya Panteleyeva, Karin Verspoor, Martha Palmer, Lawrence E Hunter
BACKGROUND: Coreference resolution is the task of finding strings in text that have the same referent as other strings. Failures of coreference resolution are a common cause of false negatives in information extraction from the scientific literature. In order to better understand the nature of the phenomenon of coreference in biomedical publications and to increase performance on the task, we annotated the Colorado Richly Annotated Full Text (CRAFT) corpus with coreference relations. RESULTS: The corpus was manually annotated with coreference relations, including identity and appositives for all coreferring base noun phrases...
August 17, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28817381/advanced-radiation-dosimetry-phantom-ardos-a-versatile-breathing-phantom-for-4d-radiation-therapy-and-medical-imaging
#11
Natalia Kostiukhina, Dietmar Georg, Sofia Rollet, Peter Kuess, Andrej Sipaj, Piotr Andrzejewski, Hugo Furtado, Ivo Rausch, Wolfgang Lechner, Elisabeth Steiner, Hunor Kertesz, Barbara Knaeusl
A novel breathing phantom was designed for being used in conventional and ion-beam radiotherapy as well as for medical imaging. Accurate dose delivery and patient safety are aimed to be verified for four-dimensional (4D) treatment techniques compensating for breathing-induced tumor motion. The phantom includes anthropomorphic components representing an average human thorax. It consists of real tissue equivalent materials to fulfill the requirements for dosimetric experiments and imaging purposes. The different parts of the torso (lungs, chest wall, and ribs) and the tumor can move independently...
August 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28817108/a-novel-approach-to-eliminate-the-effect-of-external-stress-on-interdiffusivity-measurement
#12
Weimin Chen, Qin Li, Lijun Zhang
In this paper, the interdiffusivities in fcc Co-Ni alloys at 1373 K due to different types of diffusion couple experiments were firstly re-calculated via the unified Wagner method based on the measured composition profiles. Their maximum difference due to different approaches for diffusion couple preparation was found to be larger than one order of magnitude. Then, a comprehensive analysis on the effect of different preparation methods was performed. After that, a two-step diffusion couple technique in combination with the pragmatic numerical inverse method was proposed to determine the accurate interdiffusivities by eliminating the effect of external stress...
August 17, 2017: Materials
https://www.readbyqxmd.com/read/28816904/the-relationship-between-oref-grants-and-future-nih-funding-success
#13
Vishal Hegde, Daniel Johansen, Howard Y Park, Stephen D Zoller, Christopher Hamad, Nicholas M Bernthal
BACKGROUND: The Orthopaedic Research and Education Foundation (OREF) is the leading specialty-specific nongovernmental organization providing orthopaedic funding in the United States. As extramural research funding has become increasingly difficult to acquire, one mission of the OREF is to support investigators to generate data needed to secure larger extramural funding from agencies such as the National Institutes of Health (NIH). The objectives of this study were to evaluate the rate of translating OREF faculty-level grants into subsequent NIH funding and to determine if there are identifiable factors that increase the rate of converting an OREF grant into NIH funding...
August 16, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28816681/augmented-lagrange-programming-neural-network-for-localization-using-time-difference-of-arrival-measurements
#14
Zifa Han, Chi Sing Leung, Hing Cheung So, Anthony George Constantinides
A commonly used measurement model for locating a mobile source is time-difference-of-arrival (TDOA). As each TDOA measurement defines a hyperbola, it is not straightforward to compute the mobile source position due to the nonlinear relationship in the measurements. This brief exploits the Lagrange programming neural network (LPNN), which provides a general framework to solve nonlinear constrained optimization problems, for the TDOA-based localization. The local stability of the proposed LPNN solution is also analyzed...
August 15, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28816668/fast-open-world-person-re-identification
#15
Xiatian Zhu, Botong Wu, Dongcheng Huang, Wei-Shi Zheng
Existing person re-identification (re-id) methods typically assume that (1) any probe person is guaranteed to appear in the gallery target population during deployment (i.e. closed-world), and (2) the probe set contains only a limited number of people (i.e. small search scale). Both assumptions are artificial and breached in real-world applications, since the probe population in target people search can be extremely vast in practice due to the ambiguity of probe search space boundary. Therefore, it is unrealistic that any probe person is assumed as one target people, and a large-scale search in person images is inherently demanded...
August 16, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28816665/body-structure-aware-deep-crowd-counting
#16
Siyu Huang, Xi Li, Zhongfei Zhang, Fei Wu, Shenghua Gao, Rongrong Ji, Junwei Han
Crowd counting is a challenging task, mainly due to the severe occlusions among dense crowds. This work aims to take a broader view to address crowd counting from the perspective of semantic modelling. In essence, crowd counting is a task of pedestrian semantic analysis involving three key factors: pedestrians, heads, and their context structure. The information of different body parts is an important cue to help us judge whether there exists a person at a certain position. Existing methods usually perform crowd counting from the perspective of directly modelling the visual properties of either the whole body or the heads only, without explicitly capturing the composite body-part semantic structure information that is crucial for crowd counting...
August 14, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28816662/distortion-aware-correlation-tracking
#17
Hanhui Li, Hefeng Wu, Huifang Zhang, Shujin Lin, Xiaonan Luo, Ruomei Wang
Recently, correlation filter (CF) based tracking methods have attracted considerable attention because of their high-speed performance. However, distortion, which refers to the phenomenon that the correlation outputs of CF based trackers are distorted, remains a major obstacle for these methods. In this paper, we propose a Distortion-Aware Correlation Filter (DACF) framework, which can detect distortions and recover from tracking failures. Our framework employs a simple yet effective feature termed normed correlation response to detect distortions...
August 14, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28816337/a-bag-of-concepts-approach-for-biomedical-document-classification-using-wikipedia-knowledge-spanish-english-cross-language-case-study
#18
Marcos A Mouriño-García, Roberto Pérez-Rodríguez, Luis E Anido-Rifón
OBJECTIVES: The ability to efficiently review the existing literature is essential for the rapid progress of research. This paper describes a classifier of text documents, represented as vectors in spaces of Wikipedia concepts, and analyses its suitability for classification of Spanish biomedical documents when only English documents are available for training. We propose the cross-language concept matching (CLCM) technique, which relies on Wikipedia interlanguage links to convert concept vectors from the Spanish to the English space...
August 16, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28816084/adenoviral-type-35-and-26-vectors-with-a-bidirectional-expression-cassette-in-the-e1-region-show-an-improved-genetic-stability-profile-and-potent-transgene-specific-immune-response
#19
Marija Vujadinovic, Kerstin Wunderlich, Benoit Callendret, Marina Koning, Mark Vermeulen, Barbara Sanders, Esmeralda van der Helm, Adile Gecgel, Dirk Spek, Karin de Boer, Masha Stalknecht, Jan Serroyen, Maria Grazia Pau, Hanneke Schuitemaker, Roland Zahn, Jerome Custers, Jort Vellinga
Genetic vaccines based on replication-incompetent adenoviral (AdV) vectors are currently in clinical development. Monovalent AdV vectors express one antigen from an expression cassette placed in most cases in the E1 region. For many vaccines, inclusion of several antigens is necessary in order to raise protective immunity and/or target more than one pathogen or pathogen strain. Based on the current technology, a mix of several monovalent vectors can be employed. However, a mix of the standard monovalent AdV may not be optimal with respect to manufacturing costs and the final dose per vector in humans...
August 17, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28815951/physics-based-all-atom-modeling-of-rna-energetics-and-structure
#20
REVIEW
Louis G Smith, Jianbo Zhao, David H Mathews, Douglas H Turner
The database of RNA sequences is exploding, but knowledge of energetics, structures, and dynamics lags behind. All-atom computational methods, such as molecular dynamics, hold promise for closing this gap. New algorithms and faster computers have accelerated progress in improving the reliability and accuracy of predictions. Currently, the methods can facilitate refinement of experimentally determined nuclear magnetic resonance and x-ray structures, but are 'unreliable' for predictions based only on sequence...
September 2017: Wiley Interdisciplinary Reviews. RNA
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