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https://www.readbyqxmd.com/read/29454347/oncology-nurses-beliefs-and-attitudes-towards-the-double-check-of-chemotherapy-medications-a-cross-sectional-survey-study
#1
D L B Schwappach, Katja Taxis, Yvonne Pfeiffer
BACKGROUND: Double-checking medications is a widely used strategy to enhance safe medication administration in oncology, but there is little evidence to support its effectiveness. The proliferated use of double-checking may be explained by positive attitudes towards checking among nurses. This study investigated oncology nurses' beliefs towards double-checking medication, its relation to beliefs about safety and the influence of nurses' level of experience and proximity to clinical care...
February 17, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29452799/how-to-prevent-medication-errors-in-the-operating-room-take-away-the-human-factor
#2
EDITORIAL
R S Litman
No abstract text is available yet for this article.
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29448023/simulating-spatial-distribution-of-coastal-soil-carbon-content-using-a-comprehensive-land-surface-factor-system-based-on-remote-sensing
#3
Yuan Chi, Honghua Shi, Wei Zheng, Jingkuan Sun
Surface soil carbon content (SCC) in coastal area is affected by complex factors, and revealing the SCC spatial distribution is considerably significant for judging the quantity of stored carbon and identifying the driving factors of SCC variation. A comprehensive land surface factor system (CLSFS) was established; it utilized the ecological significances of remote sensing data and included four-class factors, namely, spectrum information, ecological indices, spatial location, and land cover. Different simulation algorithms, including single-factor regression (SFR), multiple-factor regression (MFR), partial least squares regression (PLSR), and back propagation neural network (BPNN), were adopted to conduct the surface (0-30cm) SCC mapping in the Yellow River Delta in China, and a 10-fold cross validation approach was used to validate the uncertainty and accuracy of the algorithms...
February 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29447399/the-relationship-between-soldier-performance-on-the-two-mile-run-and-the-20-m-shuttle-run-test
#4
Maria C Canino, Bruce S Cohen, Jan E Redmond, Marilyn A Sharp, Edward J Zambraski, Stephen A Foulis
Background: The 20-m shuttle run test (MSRT) is a common field test used to measure aerobic fitness in controlled environments. The U.S. Army currently assesses aerobic fitness with the two-mile run (TMR), but external factors may impact test performance. The aim of this study is to examine the relationship between the Army Physical Fitness Test TMR performance and the MSRT in military personnel. Methods: A group of 531 (403 males and 128 females) active duty soldiers (age: 24...
February 13, 2018: Military Medicine
https://www.readbyqxmd.com/read/29443720/retained-guidewires-in-the-veterans-health-administration-getting-to-the-root-of-the-problem
#5
Leila Cherara, Gary L Sculli, Douglas E Paull, Lisa Mazzia, Julia Neily, Peter D Mills
OBJECTIVES: The aims of this study were to investigate the demographics, causes, and contributing factors of retained guidewires (GWs) and to make specific recommendations for their prevention. METHODS: The Veterans Administration patient safety reporting system database for 2000-2016 was queried for cases of retained GWs (RGWs). Data extracted for each case included procedure location, provider experience, insertion site, urgency, time to discovery, root causes, and corrective actions taken...
February 13, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29440520/assessing-the-relative-impact-of-historical-divergence-and-inter-group-transmission-on-cultural-patterns-a-method-from-evolutionary-ecology
#6
Noreen von Cramon-Taubadel, Stephen J Lycett
In the study of cultural evolution, observed among-group affinity patterns reflect the effects of processes such as mutation (e.g. innovation and copying error), between-group interaction (culture flow), drift and selection. As in biology, cultural affinity patterns are often spatially correlated, making it difficult to distinguish between the opposing geographically mediated forces of divergence and interaction, which cause groups to become more distinct or similar over time, respectively. Analogous difficulties are faced by evolutionary biologists examining the relationship between biological affinity and geography, particularly at lower taxonomic levels where the potential for gene flow between lineages is greatest...
April 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29437252/high-temporal-resolution-motion-estimation-using-a-self-navigated-simultaneous-multi-slice-echo-planar-imaging-acquisition
#7
Jose R Teruel, Joshua M Kuperman, Anders M Dale, Nathan S White
BACKGROUND: Subject motion is known to produce spurious covariance among time-series in functional connectivity that has been reported to induce distance-dependent spurious correlations. PURPOSE: To present a feasibility study for applying the extended Kalman filter (EKF) framework for high temporal resolution motion correction of resting state functional MRI (rs-fMRI) series using each simultaneous multi-slice (SMS) echo planar imaging (EPI) shot as its own navigator...
February 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29435555/opioid-analgesic-use-and-risk-for-invasive-pneumococcal-diseases-a-nested-case-control-study
#8
Andrew D Wiese, Marie R Griffin, William Schaffner, C Michael Stein, Robert A Greevy, Edward F Mitchel, Carlos G Grijalva
Background: Although certain opioid analgesics have immunosuppressive properties and increase the risk for infections in animals, the clinical effects of prescription opioid use on infection risk among humans are unknown. Objective: To test the hypothesis that prescription opioid use is an independent risk factor for invasive pneumococcal disease (IPD). Design: Nested case-control study. Setting: Tennessee Medicaid database linked to Medicare and Active Bacterial Core surveillance system databases (1995 to 2014)...
February 13, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29434058/improving-accuracy-of-breast-cancer-biomarker-testing-in-india
#9
REVIEW
Tanuja Shet
There is a global mandate even in countries with low resources to improve the accuracy of testing biomarkers in breast cancer viz. oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2neu) given their critical impact in the management of patients. The steps taken include compulsory participation in an external quality assurance (EQA) programme, centralized testing, and regular performance audits for laboratories. This review addresses the status of ER/PR and HER2neu testing in India and possible reasons for the delay in development of guidelines and mandate for testing in the country...
October 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29432117/closed-loop-continuous-hand-control-via-chronic-recording-of-regenerative-peripheral-nerve-interfaces
#10
Philip P Vu, Zachary T Irwin, Autumn J Bullard, Shoshana W Ambani, Ian C Sando, Melanie G Urbanchek, Paul S Cederna, Cynthia A Chestek
Loss of the upper limb imposes a devastating interruption to everyday life. Full restoration of natural arm control requires the ability to simultaneously control multiple degrees of freedom of the prosthetic arm and maintain that control over an extended period of time. Current clinically available myoelectric prostheses do not provide simultaneous control or consistency for transradial amputees. To address this issue, we have implemented a standard Kalman filter for continuous hand control using intramuscular electromyography (EMG) from both regenerative peripheral nerve interfaces (RPNI) and an intact muscle within non-human primates...
February 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29432100/her2net-a-deep-framework-for-semantic-segmentation-and-classification-of-cell-membranes-and-nuclei-in-breast-cancer-evaluation
#11
Monjoy Saha, Chandan Chakraborty
We present an efficient deep learning framework for identifying, segmenting, and classifying cell membranes and nuclei from human epidermal growth factor receptor-2 (HER2)-stained breast cancer images with minimal user intervention. This is a long-standing issue for pathologists because the manual quantification of HER2 is error-prone, costly, and time-consuming. Hence, we propose a deep learning-based HER2 deep neural network (Her2Net) to solve this issue. The convolutional and deconvolutional parts of the proposed Her2Net framework consisted mainly of multiple convolution layers, max-pooling layers, spatial pyramid pooling layers, deconvolution layers, up-sampling layers, and trapezoidal long short-term memory (TLSTM)...
May 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29432078/endogenous-tumor-suppressor-microrna-193b-therapeutic-and-prognostic-value-in-acute-myeloid-leukemia
#12
Raj Bhayadia, Kathrin Krowiorz, Nadine Haetscher, Razan Jammal, Stephan Emmrich, Askar Obulkasim, Jan Fiedler, Adrian Schwarzer, Arefeh Rouhi, Michael Heuser, Susanne Wingert, Sabrina Bothur, Konstanze Döhner, Tobias Mätzig, Michelle Ng, Dirk Reinhardt, Hartmut Döhner, C Michel Zwaan, Marry van den Heuvel Eibrink, Dirk Heckl, Maarten Fornerod, Thomas Thum, R Keith Humphries, Michael A Rieger, Florian Kuchenbauer, Jan-Henning Klusmann
Purpose Dysregulated microRNAs are implicated in the pathogenesis and aggressiveness of acute myeloid leukemia (AML). We describe the effect of the hematopoietic stem-cell self-renewal regulating miR-193b on progression and prognosis of AML. Methods We profiled miR-193b-5p/3p expression in cytogenetically and clinically characterized de novo pediatric AML (n = 161) via quantitative real-time polymerase chain reaction and validated our findings in an independent cohort of 187 adult patients. We investigated the tumor suppressive function of miR-193b in human AML blasts, patient-derived xenografts, and miR-193b knockout mice in vitro and in vivo...
February 12, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29425596/human-factors-applied-to-perioperative-process-improvement
#13
REVIEW
Joseph R Keebler, Elizabeth H Lazzara, Elizabeth Blickensderfer, Thomas D Looke
This article discusses some of the major theories of the science of human factors/ergonomics (HF/E) in relation to perioperative medicine, with a focus on safety and errors within these systems. The discussion begins with human limitations based in cognition, decision making, stress, and fatigue. Given these limitations, the importance of measuring human performance is discussed. Finally, using the HF/E perspective on safety, high-level recommendations are provided for increasing safety within the perioperative environment...
March 2018: Anesthesiology Clinics
https://www.readbyqxmd.com/read/29416077/prefrontal-cortex-modulates-the-correlations-between-brain-derived-neurotrophic-factor-level-serotonin-and-the-autonomic-nervous-system
#14
Wei Hung Chang, I Hui Lee, Mei Hung Chi, Shih-Hsien Lin, Kao Chin Chen, Po See Chen, Nan Tsing Chiu, Wei Jen Yao, Yen Kuang Yang
Top-down regulation in the human brain and anatomical connections between the prefrontal cortex (PFC) and specific catecholamine-related regions have been well-studied. However, the way in which the PFC modulates downstream neuro-networks in terms of serotonin and the autonomic nervous system (ANS) by variation in the level of brain-derived neurotrophic factor (BDNF) is still unclear. We recruited sixty-seven healthy subjects. Serotonin transporter (SERT) availability was examined by SPECT with [ 123 I]ADAM analysis; heart rate variability (HRV) testing was performed, and the BDNF level was measured...
February 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29416038/drosha-drives-the-formation-of-dna-rna-hybrids-around-dna-break-sites-to-facilitate-dna-repair
#15
Wei-Ting Lu, Ben R Hawley, George L Skalka, Robert A Baldock, Ewan M Smith, Aldo S Bader, Michal Malewicz, Felicity Z Watts, Ania Wilczynska, Martin Bushell
The error-free and efficient repair of DNA double-stranded breaks (DSBs) is extremely important for cell survival. RNA has been implicated in the resolution of DNA damage but the mechanism remains poorly understood. Here, we show that miRNA biogenesis enzymes, Drosha and Dicer, control the recruitment of repair factors from multiple pathways to sites of damage. Depletion of Drosha significantly reduces DNA repair by both homologous recombination (HR) and non-homologous end joining (NHEJ). Drosha is required within minutes of break induction, suggesting a central and early role for RNA processing in DNA repair...
February 7, 2018: Nature Communications
https://www.readbyqxmd.com/read/29413584/decision-making-financial-risk-aversion-and-behavioral-biases-the-role-of-testosterone-and-stress
#16
John R Nofsinger, Fernando M Patterson, Corey A Shank
We examine the relation between testosterone, cortisol, and financial decisions in a sample of naïve investors. We find that testosterone level is positively related to excess risk-taking, whereas cortisol level is negatively related to excess risk-taking (correlation coefficient [r]: 0.75 and -0.21, respectively). Additionally, we find support for the dual-hormone hypothesis in a financial context. Specifically, the testosterone-to-cortisol ratio is significantly related to loss aversion. Individuals with a higher ratio are 3...
January 27, 2018: Economics and Human Biology
https://www.readbyqxmd.com/read/29411563/review-of-technological-advancements-in-calibration-systems-for-laser-vision-correction
#17
Samuel Arba-Mosquera, Paolo Vinciguerra, Shwetabh Verma
Using PubMed and our internal database, we extensively reviewed the literature on the technological advancements in calibration systems, with a motive to present an account of the development history, and latest developments in calibration systems used in refractive surgery laser systems. As a second motive, we explored the clinical impact of the error introduced due to the roughness in ablation and its corresponding effect on system calibration. The inclusion criterion for this review was strict relevance to the clinical questions under research...
February 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29409659/development-of-a-positioning-aid-to-reduce-postural-variability-and-errors-in-3d-whole-body-scan-measurements
#18
Frank Schwarz-Müller, Russell Marshall, Steve Summerskill
Three-dimensional (3D) body scanners have the potential to evaluate changes to the human form through different clothing configurations, the use of protective equipment, or the effects of medical interventions. To achieve this, scans of an individual need to be superimposed for each experimental condition. The literature highlights that one of the limiting factors is postural variability. This paper describes a newly developed 'positioning aid' that stabilises the posture during the scanning process and is invisible on scans...
April 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29395460/risk-factors-for-radiotherapy-incidents-a-single-institutional-experience
#19
Hiromichi Ishiyama, Nobuaki Shuto, Tsuyoshi Terazaki, Shigetoshi Noda, Minoru Ishigami, Katsunori Yogo, Kazushige Hayakawa
We aimed to analyze risk factors for incidents occurring during the practice of external beam radiotherapy (EBRT) at a single Japanese center. Treatment data for EBRT from June 2014 to March 2017 were collected. Data from incident reports submitted during this period were reviewed. Near-miss cases were not included. Risk factors for incidents, including patient characteristics and treatment-related factors, were explored using uni- and multivariate analyses. Factors contributing to each incident were also retrospectively categorized according to the recommendations of the American Association of Physicists in Medicine (AAPM)...
January 30, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29391166/a-speculative-outlook-on-embryonic-aneuploidy-can-molecular-pathways-be-involved
#20
REVIEW
Olga Tšuiko, Tatjana Jatsenko, Lalit Kumar Parameswaran Grace, Ants Kurg, Joris Robert Vermeesch, Fredrik Lanner, Signe Altmäe, Andres Salumets
The journey of embryonic development starts at oocyte fertilization, which triggers a complex cascade of events and cellular pathways that guide early embryogenesis. Recent technological advances have greatly expanded our knowledge of cleavage-stage embryo development, which is characterized by an increased rate of whole-chromosome losses and gains, mixoploidy, and atypical cleavage morphokinetics. Embryonic aneuploidy significantly contributes to implantation failure, spontaneous miscarriage, stillbirth or congenital birth defects in both natural and assisted human reproduction...
January 31, 2018: Developmental Biology
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