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Human factors error

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https://www.readbyqxmd.com/read/28337798/latent-classes-of-polydrug-and-polyroute-use-and-associations-with-human-immunodeficiency-virus-risk-behaviours-and-overdose-among-people-who-inject-drugs-in-tijuana-baja-california-mexico
#1
Meredith C Meacham, Scott C Roesch, Steffanie A Strathdee, Suzanne Lindsay, Patricia Gonzalez-Zuniga, Tommi L Gaines
INTRODUCTION AND AIMS: Patterns of polydrug use among people who inject drugs (PWID) may be differentially associated with overdose and unique human immunodeficiency virus (HIV) risk factors. Subgroups of PWID in Tijuana, Mexico, were identified based on substances used, route of administration, frequency of use and co-injection indicators. DESIGN AND METHODS: Participants were PWID residing in Tijuana age ≥18 years sampled from 2011 to 2012 who reported injecting an illicit substance in the past month (n = 735)...
March 24, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28336671/stem-cell-divisions-somatic-mutations-cancer-etiology-and-cancer-prevention
#2
Cristian Tomasetti, Lu Li, Bert Vogelstein
Cancers are caused by mutations that may be inherited, induced by environmental factors, or result from DNA replication errors (R). We studied the relationship between the number of normal stem cell divisions and the risk of 17 cancer types in 69 countries throughout the world. The data revealed a strong correlation (median = 0.80) between cancer incidence and normal stem cell divisions in all countries, regardless of their environment. The major role of R mutations in cancer etiology was supported by an independent approach, based solely on cancer genome sequencing and epidemiological data, which suggested that R mutations are responsible for two-thirds of the mutations in human cancers...
March 24, 2017: Science
https://www.readbyqxmd.com/read/28332416/predicting-deoxynivalenol-in-oats-under-conditions-representing-scandinavian-production-regions
#3
Tomas Persson, Henrik Eckersten, Oleif Elen, Anne-Grete Roer Hjelkrem, Joel Markgren, Mats Söderström, Thomas Börjesson
Deoxynivalenol (DON) in cereals, produced by Fusarium fungi, cause poisoning in humans and animals. Fusarium infections in cereals are favoured by humid conditions. Host species are susceptible mainly during the anthesis stage. Infections are also positively correlated with a regional history of Fusarium infections, frequent cereal production and non-tillage field management practices. Here, previously developed process-based models based on relative air humidity, rain and temperature conditions, Fusarium sporulation, host phenology and mycelium growth in host tissue were adapted and tested on oats...
March 23, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28301178/practice-increases-procedural-errors-after-task-interruption
#4
Erik M Altmann, David Z Hambrick
Positive effects of practice are ubiquitous in human performance, but a finding from memory research suggests that negative effects are possible also. The finding is that memory for items on a list depends on the time interval between item presentations. This finding predicts a negative effect of practice on procedural performance under conditions of task interruption. As steps of a procedure are performed more quickly, memory for past performance should become less accurate, increasing the rate of skipped or repeated steps after an interruption...
March 16, 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/28294204/investigations-on-the-accuracy-of-3d-printed-drill-guides-for-dental-implantology
#5
André Neumeister, Linda Schulz, Christoph Glodecki
This article describes the computer-aided design/computer-aided manufacture (CAD/CAM) accuracy of dental drill guides for application in guided surgery. Today, the availability of three-dimensional (3D) desktop printers allows for the cost-effective production of drill guides by dental laboratories. Our investigations show the accuracy of produced guides by eliminating influencing factors that exist in the guided surgery workflow. To investigate this accuracy, a method was developed to evaluate the CAD/CAM production technology apart from sources of error from cone beam computed tomography (CBCT) scans, intraoral scans, software or human error...
2017: International Journal of Computerized Dentistry
https://www.readbyqxmd.com/read/28294105/breath-acetone-as-a-potential-marker-in-clinical-practice
#6
Vera Ruzsanyi, Miklós Kalapos
In recent decades, two facts have changed the opinion of researchers about the function of acetone in humans. Firstly, it has turned out that acetone cannot be regarded as simply a waste product of metabolism, because there are several pathways in which acetone is produced or broken down. Secondly, methods have emerged making possible its detection in exhaled breath, thereby offering an attractive alternative to investigation of blood and urine samples. From a clinical point of view the measurement of breath acetone levels are important, but there are limitations to its wide application...
March 15, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28291846/are-human-factors-the-primary-cause-of-complications-in-the-field-of-implant-dentistry
#7
Franck Renouard, René Amalberti, Erell Renouard
Complications in medicine and dentistry are usually analyzed from a purely technical point of view. Rarely is the role of human behavior or judgment considered as a reason for adverse outcomes. When the role of human factors is considered, these are usually described in general terms rather than specifically identifying the factors responsible for an adverse event. The impact of cognitive and behavioral factors in the explanation of adverse events has been studied in other high-stakes areas such as aviation and nuclear power...
March 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28291756/twilight-reloaded-the-peptide-experience
#8
Christian X Weichenberger, Edwin Pozharski, Bernhard Rupp
The de facto commoditization of biomolecular crystallography as a result of almost disruptive instrumentation automation and continuing improvement of software allows any sensibly trained structural biologist to conduct crystallographic studies of biomolecules with reasonably valid outcomes: that is, models based on properly interpreted electron density. Robust validation has led to major mistakes in the protein part of structure models becoming rare, but some depositions of protein-peptide complex structure models, which generally carry significant interest to the scientific community, still contain erroneous models of the bound peptide ligand...
March 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28284440/thinking-forensics-cognitive-science-for-forensic-practitioners
#9
REVIEW
Gary Edmond, Alice Towler, Bethany Growns, Gianni Ribeiro, Bryan Found, David White, Kaye Ballantyne, Rachel A Searston, Matthew B Thompson, Jason M Tangen, Richard I Kemp, Kristy Martire
Human factors and their implications for forensic science have attracted increasing levels of interest across criminal justice communities in recent years. Initial interest centred on cognitive biases, but has since expanded such that knowledge from psychology and cognitive science is slowly infiltrating forensic practices more broadly. This article highlights a series of important findings and insights of relevance to forensic practitioners. These include research on human perception, memory, context information, expertise, decision-making, communication, experience, verification, confidence, and feedback...
March 2017: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/28281431/the-accuracy-of-nurse-performance-of-the-triage-process-in-a-tertiary-hospital-emergency-department-in-gauteng-province-south-africa
#10
L N Goldstein, L M Morrow, T A Sallie, K Gathoo, K Alli, T M M Mothopeng, F Samodien
BACKGROUND: Triage in the emergency department (ED) is necessary to prioritise management according to the severity of a patient's condition.The South African Triage Scale (SATS) is a hospital-based triage tool that has been adopted by numerous EDs countrywide.Many factors can influence the outcome of a patient's triage result, and evaluation of performance is therefore pivotal. OBJECTIVES: To determine how often patients were allocated to the correct triage category and the extent to which they were incorrectly promoted or demoted, and to determine the main reasons for errors in a nurse-led triage system...
February 27, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28279915/low-rank-and-sparse-decomposition-based-shape-model-and-probabilistic-atlas-for-automatic-pathological-organ-segmentation
#11
Changfa Shi, Yuanzhi Cheng, Jinke Wang, Yadong Wang, Kensaku Mori, Shinichi Tamura
One major limiting factor that prevents the accurate delineation of human organs has been the presence of severe pathology and pathology affecting organ borders. Overcoming these limitations is exactly what we are concerned in this study. We propose an automatic method for accurate and robust pathological organ segmentation from CT images. The method is grounded in the active shape model (ASM) framework. It leverages techniques from low-rank and sparse decomposition (LRSD) theory to robustly recover a subspace from grossly corrupted data...
February 22, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28271956/diagnosing-barriers-to-safety-and-efficiency-in-robotic-surgery
#12
Ken R Catchpole, Elyse Hallett, Sam Curtis, Tannaz Mirchi, Colby P Souders, Jennifer T Anger
Recent studies exploring the effects of surgical robots on teamwork are revealing challenges not reflected in clinical studies. This study is a sub analysis of observational data collected from 89 procedures utilising the da Vinci systems. Previous analyses had demonstrated interactions between flow disruptions and contextual factors. This study sought a more granular analysis to provide better insight for improvement. Raters sub-classified disruptions, based upon the original notes, grouped according to four operative phases (pre-robot; docking; surgeon on console; undocking; and finish)...
March 8, 2017: Ergonomics
https://www.readbyqxmd.com/read/28269397/hardness-map-of-human-meta-tarsals-and-phalanges-of-toes
#13
Irfan Manarvi
Predicting location of fracture in human bones has been a keen area of research for the past few decades. A variety of tests for hardness, deformation and strain field measurement have been conducted in the past; but considered insufficient due to various limitations. Researchers therefore have proposed further studies due to inaccuracies in measurement methods, testing machines and experimental errors. Advancement and availability of hardware, measuring instrumentation and testing machines can now provide remedies to these limitations...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268657/effects-of-input-frequency-content-and-signal-to-noise-ratio-on-the-parametric-estimation-of-surface-emg-torque-dynamics
#14
Mahsa A Golkar, Robert E Kearney
The dynamic relationship between surface EMG (sEMG) and torque can be estimated from data acquired while subjects voluntarily modulate joint torque. We have shown that for such data, the input (EMG) contains a feedback component from the output (torque) and so accurate estimates of the dynamics require the use of closed-loop identification algorithms. Moreover, this approach has several other limitations since the input is controlled indirectly and so the frequency content and signal-to-noise ratio cannot be controlled...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263315/whole-genome-sequencing-identifies-common-to-rare-variants-associated-with-human-blood-metabolites
#15
Tao Long, Michael Hicks, Hung-Chun Yu, William H Biggs, Ewen F Kirkness, Cristina Menni, Jonas Zierer, Kerrin S Small, Massimo Mangino, Helen Messier, Suzanne Brewerton, Yaron Turpaz, Brad A Perkins, Anne M Evans, Luke A D Miller, Lining Guo, C Thomas Caskey, Nicholas J Schork, Chad Garner, Tim D Spector, J Craig Venter, Amalio Telenti
Genetic factors modifying the blood metabolome have been investigated through genome-wide association studies (GWAS) of common genetic variants and through exome sequencing. We conducted a whole-genome sequencing study of common, low-frequency and rare variants to associate genetic variations with blood metabolite levels using comprehensive metabolite profiling in 1,960 adults. We focused the analysis on 644 metabolites with consistent levels across three longitudinal data collections. Genetic sequence variations at 101 loci were associated with the levels of 246 (38%) metabolites (P ≤ 1...
March 6, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28258022/probes-for-protein-adduction-in-cholesterol-biosynthesis-disorders-alkynyl-lanosterol-as-a-viable-sterol-precursor
#16
Keri A Tallman, Hye-Young H Kim, Zeljka Korade, Thiago C Genaro-Mattos, Phillip A Wages, Wei Liu, Ned A Porter
The formation of lipid electrophile-protein adducts is associated with many disorders that involve perturbations of cellular redox status. The identities of adducted proteins and the effects of adduction on protein function are mostly unknown and an increased understanding of these factors may help to define the pathogenesis of various human disorders involving oxidative stress. 7-Dehydrocholesterol (7-DHC), the immediate biosynthetic precursor to cholesterol, is highly oxidizable and gives electrophilic oxysterols that adduct proteins readily, a sequence of events proposed to occur in Smith-Lemli-Opitz syndrome (SLOS), a human disorder resulting from an error in cholesterol biosynthesis...
February 24, 2017: Redox Biology
https://www.readbyqxmd.com/read/28257288/root-cause-analyses-of-reported-adverse-events-occurring-during-gastrointestinal-scope-and-tube-placement-procedures-in-the-veterans-health-association
#17
Christina Soncrant, Peter D Mills, Julia Neily, Douglas E Paull, Robin R Hemphill
OBJECTIVE: This study describes reported adverse events related to gastrointestinal (GI) scope and tube placement procedures (between January 2010 and June 2012), in the Veterans Health Administration. Adverse events, including those related to GI procedures resulting in preventable harm, continue to occur. METHODS: This is a descriptive review of root cause analysis reports of GI scope and tube placement procedures from the National Center for Patient Safety database...
March 3, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28256928/performance-assessment-of-human-resource-by-integration-of-hse-and-ergonomics-and-efqm-management-system
#18
Mohsen Sadegh Amalnick, Mansour Zarrin
Purpose The purpose of this paper is to present an integrated framework for performance evaluation and analysis of human resource (HR) with respect to the factors of health, safety, environment and ergonomics (HSEE) management system, and also the criteria of European federation for quality management (EFQM) as one of the well-known business excellence models. Design/methodology/approach In this study, an intelligent algorithm based on adaptive neuro-fuzzy inference system (ANFIS) along with fuzzy data envelopment analysis (FDEA) are developed and employed to assess the performance of the company...
March 13, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28255522/opportunities-to-foster-efficient-communication-in-labor-and-delivery-using-simulation
#19
Kay Daniels, Colleen Hamilton, Susan Crowe, Steven S Lipman, Louis P Halamek, Henry C Lee
Introduction Communication errors are an important contributing factor in adverse outcomes in labor and delivery (L&D) units. The objective of this study was to identify common lapses in verbal communication using simulated obstetrical scenarios and propose alternative formats for communication. Methods Health care professionals in L&D participated in three simulated clinical scenarios. Scenarios were recorded and reviewed to identify questions repeated within and across scenarios. Questions that were repeated more than once due to ineffective communication were identified...
January 2017: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/28254071/semi-automated-detection-of-anterior-cruciate-ligament-injury-from-mri
#20
Ivan Štajduhar, Mihaela Mamula, Damir Miletić, Gözde Ünal
BACKGROUND AND OBJECTIVES: A radiologist's work in detecting various injuries or pathologies from radiological scans can be tiresome, time consuming and prone to errors. The field of computer-aided diagnosis aims to reduce these factors by introducing a level of automation in the process. In this paper, we deal with the problem of detecting the presence of anterior cruciate ligament (ACL) injury in a human knee. We examine the possibility of aiding the diagnosis process by building a decision-support model for detecting the presence of milder ACL injuries (not requiring operative treatment) and complete ACL ruptures (requiring operative treatment) from sagittal plane magnetic resonance (MR) volumes of human knees...
March 2017: Computer Methods and Programs in Biomedicine
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