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Human factors error

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https://www.readbyqxmd.com/read/28227640/hardness-map-of-human-meta-tarsals-and-phalanges-of-toes
#1
Irfan Manarvi, Irfan Manarvi, Irfan Manarvi
Predicting location of fracture in human bones has been a keen area of research for the past few decades. A variety of tests for hardness, deformation and strain field measurement have been conducted in the past; but considered insufficient due to various limitations. Researchers therefore have proposed further studies due to inaccuracies in measurement methods, testing machines and experimental errors. Advancement and availability of hardware, measuring instrumentation and testing machines can now provide remedies to these limitations...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226840/effects-of-input-frequency-content-and-signal-to-noise-ratio-on-the-parametric-estimation-of-surface-emg-torque-dynamics
#2
Mahsa A Golkar, Robert E Kearney, Mahsa A Golkar, Robert E Kearney, Mahsa A Golkar, Robert E Kearney
The dynamic relationship between surface EMG (sEMG) and torque can be estimated from data acquired while subjects voluntarily modulate joint torque. We have shown that for such data, the input (EMG) contains a feedback component from the output (torque) and so accurate estimates of the dynamics require the use of closed-loop identification algorithms. Moreover, this approach has several other limitations since the input is controlled indirectly and so the frequency content and signal-to-noise ratio cannot be controlled...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223907/comparative-bioavailability-and-utilization-of-particular-forms-of-b12-supplements-with-potential-to-mitigate-b12-related-genetic-polymorphisms
#3
REVIEW
Cristiana Paul, David M Brady
CONTEXT: Three natural forms of vitamin B12 are commercially available: methylcobalamin (MeCbl), adenosylcobalamin (AdCbl), and hydroxycobalamin (OHCbl), all of which have been shown in clinical studies to improve vitamin B12 status. They are bioidentical to the B12 forms occurring in human physiology and animal foods. In contrast, cyanocobalamin (CNCbl), a synthetic B12 compound used for food fortification and in some supplements, occurs only in trace amounts in human tissues as a result of cyanide intake from smoking or other sources...
February 2017: Integrative Medicine
https://www.readbyqxmd.com/read/28221087/fechner-s-law-in-metacognition-a-quantitative-model-of-visual-working-memory-confidence
#4
Ronald van den Berg, Aspen H Yoo, Wei Ji Ma
Although visual working memory (VWM) has been studied extensively, it is unknown how people form confidence judgments about their memories. Peirce (1878) speculated that Fechner's law-which states that sensation is proportional to the logarithm of stimulus intensity-might apply to confidence reports. Based on this idea, we hypothesize that humans map the precision of their VWM contents to a confidence rating through Fechner's law. We incorporate this hypothesis into the best available model of VWM encoding and fit it to data from a delayed-estimation experiment...
March 2017: Psychological Review
https://www.readbyqxmd.com/read/28214730/risk-aversion-and-religious-behaviour-analysis-using-a-sample-of-danish-twins
#5
Jytte Seested Nielsen, Mickael Bech, Kaare Christensen, Astrid Kiil, Niels Christian Hvidt
Economics offers an analytical framework to consider human behaviour including religious behaviour. Within the realm of Expected Utility Theory, religious belief and activity could be interpreted as an insurance both for current life events and for afterlife rewards. Based on that framework, we would expect that risk averse individuals would demand a more generous protection plan which they may do by devoting more effort and resources into religious activities such as church attendance and prayer, which seems to be in accordance with previous empirical results...
February 12, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/28196412/mapk3-at-the-autism-linked-human-16p11-2-locus-influences-precise-synaptic-target-selection-at-drosophila-larval-neuromuscular-junctions
#6
Sang Mee Park, Hae Ryoun Park, Ji Hye Lee
Proper synaptic function in neural circuits requires precise pairings between correct pre- and post-synaptic partners. Errors in this process may underlie development of neuropsychiatric disorders, such as autism spectrum disorder (ASD). Development of ASD can be influenced by genetic factors, including copy number variations (CNVs). In this study, we focused on a CNV occurring at the 16p11.2 locus in the human genome and investigated potential defects in synaptic connectivity caused by reduced activities of genes located in this region at Drosophila larval neuromuscular junctions, a well-established model synapse with stereotypic synaptic structures...
February 15, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28186187/factors-associated-with-aberrant-imprint-methylation-and-oligozoospermia
#7
Norio Kobayashi, Naoko Miyauchi, Nozomi Tatsuta, Akane Kitamura, Hiroaki Okae, Hitoshi Hiura, Akiko Sato, Takafumi Utsunomiya, Nobuo Yaegashi, Kunihiko Nakai, Takahiro Arima
Disturbingly, the number of patients with oligozoospermia (low sperm count) has been gradually increasing in industrialized countries. Epigenetic alterations are believed to be involved in this condition. Recent studies have clarified that intrinsic and extrinsic factors can induce epigenetic transgenerational phenotypes through apparent reprogramming of the male germ line. Here we examined DNA methylation levels of 22 human imprinted loci in a total of 221 purified sperm samples from infertile couples and found methylation alterations in 24...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28185075/paediatric-patient-safety-and-the-need-for-aviation-black-box-thinking-to-learn-from-and-prevent-medication-errors
#8
Chi Huynh, Ian C K Wong, Jo Correa-West, David Terry, Suzanne McCarthy
Since the publication of To Err Is Human: Building a Safer Health System in 1999, there has been much research conducted into the epidemiology, nature and causes of medication errors in children, from prescribing and supply to administration. It is reassuring to see growing evidence of improving medication safety in children; however, based on media reports, it can be seen that serious and fatal medication errors still occur. This critical opinion article examines the problem of medication errors in children and provides recommendations for research, training of healthcare professionals and a culture shift towards dealing with medication errors...
February 10, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28184917/-corrigendum-loss-of-runt%C3%A2-related-transcription-factor%C3%A2-3-induces-resistance-to-5%C3%A2-fluorouracil-and-cisplatin-in-hepatocellular-carcinoma
#9
Junro Kataoka, Hidenori Shiraha, Shigeru Horiguchi, Hiroaki Sawahara, Daisuke Uchida, Teruya Nagahara, Masaya Iwamuro, Hiroki Morimoto, Yasuto Takeuchi, Kenji Kuwaki, Hideki Onishi, Shinichiro Nakamura, Akinobu Takaki, Kazuhiro Nouso, Takahito Yagi, Kazuhide Yamamoto, Hiroyuki Okada
Following the publication of this article, we realize that there were some errors in the manuscript. Details of the experiments describing the gene silencing of RUNX3 with small interfering RNA (siRNA) were erroneously included in this paper, and all references to siRNA should have been deleted from the manuscript prior to publication. In the subsection entitled 'Cell lines and cell culture' on page 2577, the left‑hand column, the text should have indicated that the human HCC cell lines Hep3B and Huh7 were obtained from the American Type Culture Collection (ATCC; Manassas, VA, USA), whereas HLF cells were obtained from the Japanese Cancer Resources Bank (Tokyo, Japan)...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28179375/quantitative-prediction-of-human-renal-clearance-and-drug-drug-interactions-of-organic-anion-transporter-substrates-using-in-vitro-transport-data
#10
Sumathy Mathialagan, Mary A Piotrowski, David A Tess, Bo Feng, John Litchfiled, Manthena V Varma
Organic anion transporters (OATs) play an important role in the renal secretion of drugs, and their functional change can result in pharmacokinetic variability. In this study, we applied transport rates measured using OAT-transfected human embryonic kidney cells to predict human renal secretory and total renal clearance of 31 diverse drugs. Selective substrates to OAT1 (tenofovir), OAT2 (acyclovir and ganciclovir) and OAT3 (benzylpenicillin, oseltamivir acid) were used to obtain relative activity factors (RAFs) for these individual transporters by relating in vitro transport clearance to in vivo secretory clearance...
February 8, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28176899/subcutaneous-sumatriptan-delivery-devices-comparative-ease-of-use-and-preference-among-migraineurs
#11
Anthony D Andre, Elimor Brand-Schieber, Margarita Ramirez, Sagar Munjal, Rajesh Kumar
BACKGROUND: Several sumatriptan subcutaneous autoinjector devices for acute treatment of migraine patients are available, each device differs with respect to design and features. Determining device preference and ease of use is important because patients experiencing a migraine attack are often functionally impaired. OBJECTIVE: The objective of this human factors study was to compare migraine patients' device use performance and preferences for three sumatriptan subcutaneous autoinjectors: a disposable two-step device (Zembrace(®) SymTouch(®)), a disposable three-step device (Sumavel(®) DosePro(®)), and a multistep reloadable device (Imitrex(®) STATdose(®)), using simulated injections...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28155030/compositional-analysis-of-topsoil-metals-and-its-associations-with-cancer-mortality-using-spatial-misaligned-data
#12
Gonzalo López-Abente, Juan Locutura-Rupérez, Pablo Fernández-Navarro, Iván Martín-Méndez, Alejandro Bel-Lan, Olivier Núñez
The presence of toxic metals in soil per se, and in soil impacted by mining, industry, agriculture and urbanisation in particular, is a major concern for both human health and ecotoxicology. The dual aim of this study was: to ascertain whether topsoil composition could influence the spatial distribution of mortality due to different types of cancer and to identify possible errors committed by epidemiological studies which analyse soil composition data as a closed number system. We conducted an ecological cancer mortality study, covering 861,440 cancer deaths (27 cancer sites) in 7917 Spanish mainland towns, from 1999 to 2008...
February 2, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28137366/somatic-mutations-in-cancer-stochastic-versus-predictable
#13
Barry Gold
The origins of human cancers remain unclear except for a limited number of potent environmental mutagens, such as tobacco and UV light, and in rare cases, familial germ line mutations that affect tumor suppressor genes or oncogenes. A significant component of cancer etiology has been deemed stochastic and correlated with the number of stem cells in a tissue, the number of times the stem cells divide and a low incidence of random DNA polymerase errors that occur during each cell division. While somatic mutations occur during each round of DNA replication, mutations in cancer driver genes are not stochastic...
February 2017: Mutation Research
https://www.readbyqxmd.com/read/28135361/integrated-comparison-of-gwas-transcriptome-and-proteomics-studies-highlights-similarities-in-the-biological-basis-of-animal-and-human-myopia
#14
Nina Riddell, Sheila G Crewther
Purpose: To identify commonalities between the genes in close proximity to genome-wide association study (GWAS) refractive error and axial length loci, and the genes and proteins differentially expressed in animal models of optically induced refractive error. Methods: The GWAS catalog was searched for loci significantly (P ≤ 5*10-8) associated with refractive error or axial length. PubMed was searched for exploratory animal transcriptome and proteomics studies of optically induced refractive error...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28133746/development-of-an-autonomous-treatment-planning-strategy-for-radiation-therapy-with-effective-use-of-population-based-prior-data
#15
Huan Wang, Peng Dong, Hongcheng Liu, Lei Xing
PURPOSE: Current treatment planning remains a costly and labor intensive procedure and requires multiple trial-and-error adjustments of system parameters such as the weighting factors and prescriptions. The purpose of this work is to develop an autonomous treatment planning strategy with effective use of prior knowledge and in a clinically realistic treatment planning platform to facilitate radiation therapy workflow. METHOD: Our technique consists of three major components: (i) a clinical treatment planning system (TPS); (ii) a formulation of decision-function constructed using an assemble of prior treatment plans; (iii) a plan evaluator or decision-function and an outer-loop optimization independent of the clinical TPS to assess the TPS-generated plan and to drive the search toward a solution optimizing the decision-function...
December 10, 2016: Medical Physics
https://www.readbyqxmd.com/read/28131800/changing-objective-structured-clinical-examinations-stations-at-lunchtime-during-all-day-postgraduate-surgery-examinations-improves-examiner-morale-and-stress
#16
Peter A Brennan, Duncan S Scrimgeour, Sheena Patel, Roshnee Patel, Gareth Griffiths, David T Croke, Lee Smith, Richard Arnett
BACKGROUND: Human factors are important causes of error, but little is known about their possible effect during objective structured clinical examinations (OSCE). We have previously identified stress and pressure in OSCE examiners in the postgraduate intercollegiate Membership of the Royal College of Surgeons (MRCS) examination. After modifying examination delivery by changing OSCE stations at lunchtime with no demonstrable effect on candidate outcome, we resurveyed examiners to ascertain whether examiner experience was improved...
January 25, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28129323/target-uncertainty-mediates-sensorimotor-error-correction
#17
Luigi Acerbi, Sethu Vijayakumar, Daniel M Wolpert
Human movements are prone to errors that arise from inaccuracies in both our perceptual processing and execution of motor commands. We can reduce such errors by both improving our estimates of the state of the world and through online error correction of the ongoing action. Two prominent frameworks that explain how humans solve these problems are Bayesian estimation and stochastic optimal feedback control. Here we examine the interaction between estimation and control by asking if uncertainty in estimates affects how subjects correct for errors that may arise during the movement...
2017: PloS One
https://www.readbyqxmd.com/read/28117753/risks-at-the-dna-replication-fork-effects-upon-carcinogenesis-and-tumor-heterogeneity
#18
REVIEW
Tony M Mertz, Victoria Harcy, Steven A Roberts
The ability of all organisms to copy their genetic information via DNA replication is a prerequisite for cell division and a biological imperative of life. In multicellular organisms, however, mutations arising from DNA replication errors in the germline and somatic cells are the basis of genetic diseases and cancer, respectively. Within human tumors, replication errors additionally contribute to mutator phenotypes and tumor heterogeneity, which are major confounding factors for cancer therapeutics. Successful DNA replication involves the coordination of many large-scale, complex cellular processes...
January 22, 2017: Genes
https://www.readbyqxmd.com/read/28115253/gold-nanorods-reflectance-discriminate-benign-from-malignant-oral-lesions
#19
Abraham Hirshberg, Irit Allon, Ilya Novikov, Rinat Ankri, Ariel Ashkenazy, Dror Fixler
Nanoparticle-based contrast agents have been used as an imaging tool for selectively detecting cancerous processes. We aimed to evaluate the detection sensitivity of reflection measurements of gold nanorods (GNRs) bio-conjugated to anti-epidermal growth factor receptor (GNRs-EGFR) monoclonal antibodies in discriminating benign from premalignant and malignant human oral lesions. Tissue sections incubated with GNRs-EGFR and the reflectance spectrum was measured using hyperspectral microscopy. Reflectance intensity increased with the progression of the disease, lowest in the control group and increasing as the dysplastic changes increase (p<0...
January 20, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28110729/epileptic-seizure-detection-in-eeg-signals-using-tunable-q-factor-wavelet-transform-and-bootstrap-aggregating
#20
Ahnaf Rashik Hassan, Siuly Siuly, Yanchun Zhang
BACKGROUND AND OBJECTIVE: Epileptic seizure detection is traditionally performed by expert clinicians based on visual observation of EEG signals. This process is time-consuming, burdensome, reliant on expensive human resources, and subject to error and bias. In epilepsy research, on the other hand, manual detection is unsuitable for handling large data-sets. A computerized seizure identification scheme can eradicate the aforementioned problems, aid clinicians, and benefit epilepsy research...
December 2016: Computer Methods and Programs in Biomedicine
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