Urvakhsh Meherwan Mehta, Dhruva Ithal, Neelabja Roy, Shreshth Shekhar, Ramajayam Govindaraj, Chaitra T Ramachandraiah, Nicolas R Bolo, Rose Dawn Bharath, Jagadisha Thirthalli, Ganesan Venkatasubramanian, Bangalore N Gangadhar, Matcheri S Keshavan
BACKGROUND: Identifying stable and consistent resting-state functional connectivity (rsFC) patterns across illness trajectories has the potential to be considered fundamental to the pathophysiology of schizophrenia. We aimed to identify consistent rsFC patterns across heterogeneous schizophrenia groups defined based on treatment response. METHODS: In phase-1, we used a cross-sectional, case-control design to characterize and compare stable independent component networks from rs-fMRI scans between antipsychotic-naïve first-episode schizophrenia participants (N=54) and healthy subjects (N=43); we also examined their associations with symptoms, cognition, and disability...
February 7, 2024: Biological Psychiatry