Anne C McLean-Holden, Lisa M Rooper, Daniel J Lubin, Kelly R Magliocca, Varsha Manucha, Peter M Sadow, Jonathan Tobias, Richard J Vargo, Lester D R Thompson, Amin Heidarian, Ilan Weinreb, Bruce Wenig, Jeffrey Gagan, Juan C Hernandez-Prera, Justin A Bishop
Intraductal carcinoma (IDC) of the salivary glands is an uncommon and enigmatic tumor, our understanding of which is rapidly evolving. Recent studies have demonstrated multiple IDC subtypes and consistent gene fusions, most frequently involving RET. Because IDC is a ductal proliferation surrounded by flattened myoepithelial cells, it was previously presumed to be analogous to breast ductal carcinoma in situ, but recent evidence has shown that the myoepithelial cells of fusion-positive IDC harbor the same genetic alterations of the ductal cells and are therefore neoplastic...
September 2022: Head and Neck Pathology