keyword
https://read.qxmd.com/read/36096861/e3-ubiquitin-ligase-trim33-ubiquitylates-annexin-a2-to-promote-nf-%C3%AE%C2%BAb-induced-skin-inflammation-in-psoriasis
#21
JOURNAL ARTICLE
Jie Zhang, Jiuling Zhu, Xiaowen Chen, Haibin Xia, Luting Yang
BACKGROUND: Tripartite motif-containing protein 33, a member of the TRIM E3 ligase family, is shown to be involved in tumorigenesis, cell proliferation and inflammation. Alteration of several TRIM family proteins in psoriatic epidermis has been shown to participate in psoriasis pathogenesis. However, little is known about Trim33 expression and its role in psoriasis. OBJECTIVES: To examine the expression and biological roles of Trim33 in psoriatic process, with a focus on identifying its novel substrates in psoriatic keratinocytes...
September 2022: Journal of Dermatological Science
https://read.qxmd.com/read/36052696/trim33-conditions-the-lifespan-of-primitive-macrophages-and-onset-of-definitive-macrophage-production
#22
JOURNAL ARTICLE
Doris Lou Demy, Anne-Lou Touret, Mylène Lancino, Muriel Tauzin, Lavinia Capuana, Constance Pierre, Philippe Herbomel
TRIM33 (Tif1-γ) is a transcriptional regulator notably involved in several aspects of hematopoiesis. It is essential for the production of erythrocytes in zebrafish, and for the proper functionning and aging of hematopoietic stem and progenitor cells (HSPCs) in mice. Here we have found that in zebrafish development, Trim33 is essential cell-autonomously for the lifespan of the yolk sac derived primitive macrophages, as well as for the initial production of definitive (HSPC-derived) macrophages in the first niche of definitive hematopoiesis, the caudal hematopoietic tissue...
September 2, 2022: Development
https://read.qxmd.com/read/35929141/downregulation-of-trim33-promotes-survival-and-epithelial-mesenchymal-transition-in-gastric-cancer
#23
JOURNAL ARTICLE
Fang Wang, Wenjun Wang, Xiaoting Wu, Cui Tang, Fang Du, Zhiguo Lu, Zhuoyang Zhang, Hui Xu, Xiangmei Cao, P Andy Li
Among all malignancies worldwide, gastric cancer is the fifth most common cancer with the third highest mortality rate. One of the main reasons for the low survival rate is the recurrence and metastasis that occurs in many patients after surgery. Numerous studies have shown that abnormal TRIM33 expression is associated with the progression of malignant tumors. TRIM33 can function either as a tumor suppressor or tumor promoter in different cancers. Our data showed that TRIM33 was highly expressed in stomach cancer, and in human gastric cancer tissues, low expression of TRIM33 was associated with poor prognosis in patients with gastric cancer...
January 2022: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/35924985/correlations-of-expression-of-nuclear-and-mitochondrial-genes-in-triploid-fish
#24
JOURNAL ARTICLE
Jialin Cui, Hong Zhang, Xin Gao, Xueyin Zhang, Mengxue Luo, Li Ren, Shaojun Liu
The expression of nuclear and mitochondrial genes, as well as their coordinated control, regulates cell proliferation, individual development, and disease in animals. However, the potential coregulation between nuclear and mitochondrial genes is unclear in triploid fishes. The two triploids (R2C and RC2) with distinct mitochondrial genomes but similar nuclear genomes exhibit different embryonic development times and growth rates. They are an excellent model for studying how nuclear and mitochondrial genes coordinate...
August 4, 2022: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/35906200/hsf1-phosphorylation-establishes-an-active-chromatin-state-via-the-trrap-tip60-complex-and-promotes-tumorigenesis
#25
JOURNAL ARTICLE
Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai
Transcriptional regulation by RNA polymerase II is associated with changes in chromatin structure. Activated and promoter-bound heat shock transcription factor 1 (HSF1) recruits transcriptional co-activators, including histone-modifying enzymes; however, the mechanisms underlying chromatin opening remain unclear. Here, we demonstrate that HSF1 recruits the TRRAP-TIP60 acetyltransferase complex in HSP72 promoter during heat shock in a manner dependent on phosphorylation of HSF1-S419. TRIM33, a bromodomain-containing ubiquitin ligase, is then recruited to the promoter by interactions with HSF1 and a TIP60-mediated acetylation mark, and cooperates with the related factor TRIM24 for mono-ubiquitination of histone H2B on K120...
July 29, 2022: Nature Communications
https://read.qxmd.com/read/35785414/trim33-drives-prostate-tumor-growth-by-stabilizing-androgen-receptor-from-skp2-mediated-degradation
#26
JOURNAL ARTICLE
Mi Chen, Shreyas Lingadahalli, Nitin Narwade, Kate Man Kei Lei, Shanshan Liu, Zuxianglan Zhao, Yimin Zheng, Qian Lu, Alexander Hin Ning Tang, Terence Chuen Wai Poon, Edwin Cheung
Androgen receptor (AR) is a master transcription factor that drives prostate cancer (PCa) development and progression. Alterations in the expression or activity of AR coregulators significantly impact the outcome of the disease. Using a proteomics approach, we identified the tripartite motif-containing 33 (TRIM33) as a novel transcriptional coactivator of AR. We demonstrate that TRIM33 facilitates AR chromatin binding to directly regulate a transcription program that promotes PCa progression. TRIM33 further stabilizes AR by protecting it from Skp2-mediated ubiquitination and proteasomal degradation...
August 3, 2022: EMBO Reports
https://read.qxmd.com/read/35697802/identification-of-a-novel-calpain-2-src-feed-back-loop-as-necessity-for-%C3%AE-catenin-accumulation-and-signaling-activation-in-hepatocellular-carcinoma
#27
JOURNAL ARTICLE
Xiao-Lu Ma, Ke-Yu Zhu, Yue-Da Chen, Wei-Guo Tang, Su-Hong Xie, Hui Zheng, Ying Tong, Yan-Chun Wang, Ning Ren, Lin Guo, Ren-Quan Lu
Rapid progression is the major cause of the poor prognosis of hepatocellular carcinoma (HCC); however, the underlying mechanism remained unclear. Here, we found Calpain-2 (CAPN2), a well-established protease that accelerates tumor progression in several malignancies, is overexpressed in HCC and acts as an independent predictor for poor outcomes. Furthermore, CAPN2 promoted the proliferation and invasion of HCC, and showed a positive correlation with the levels of invasion-related markers. Mechanistically, a novel CAPN2-SRC positive regulatory loop was identified upstream of β-catenin to prevent its ubiquitination and degradation, and subsequently promoted HCC progression: CAPN2 could proteolyze PTP1B to form a truncation of approximately 42 kDa with increased phosphatase activity, resulting in reduced SRC Y530 phosphorylation and increased SRC kinase activity; meanwhile, CAPN2 itself was a bone fide substrate of SRC that was primarily phosphorylated at Y625 by SRC and exhibited increased proteolysis activity upon phosphorylation...
June 13, 2022: Oncogene
https://read.qxmd.com/read/35636393/trim33-modulates-inflammation-and-airway-remodeling-of-pdgf-bb-induced-airway-smooth-muscle-cells-by-the-wnt-%C3%AE-catenin-pathway
#28
JOURNAL ARTICLE
Jia Li, Xuyan Wang, Yufei Su, Shuwen Hu, Jing Chen
Asthma is a chronic airway disease involving airway inflammation and remodeling. Studies showed that tripartite motif-containing protein 33 (TRIM33) regulated natural immunity, inflammation, and pulmonary fibrosis. However, the role and regulatory mechanism of TRIM33 in children's asthma are unclear. In this study, the TRIM33 expressions in serum samples and platelet-derived growth factor BB (PDGF-BB)-induced airway smooth-muscle cells (ASMCs) were evaluated. A gain-of-function experiment was performed, and cell proliferation and migration were detected using CCK-8 and wound healing assays...
May 30, 2022: International Archives of Allergy and Immunology
https://read.qxmd.com/read/35563606/transcriptional-contribution-of-transposable-elements-in-relation-to-salinity-conditions-in-teleosts-and-silencing-mechanisms-involved
#29
JOURNAL ARTICLE
Elisa Carotti, Federica Carducci, Samuele Greco, Marco Gerdol, Daniele Di Marino, Nunzio Perta, Anna La Teana, Adriana Canapa, Marco Barucca, Maria Assunta Biscotti
Fish are an interesting taxon comprising species adapted to a wide range of environments. In this work, we analyzed the transcriptional contribution of transposable elements (TEs) in the gill transcriptomes of three fish species exposed to different salinity conditions. We considered the giant marbled eel Anguilla marmorata and the chum salmon Oncorhynchus keta , both diadromous, and the marine medaka Oryzias melastigma , an euryhaline organism sensu stricto. Our analyses revealed an interesting activity of TEs in the case of juvenile eels, commonly adapted to salty water, when exposed to brackish and freshwater conditions...
May 6, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35333698/the-crystallin-alpha-b-hspb5-tripartite-motif-containing-33-trim33-axis-mediates-myocardial-fibrosis-induced-by-angiotensinogen-ii-through-transforming-growth-factor-%C3%AE-tgf-%C3%AE-1-smad3-4-signaling
#30
JOURNAL ARTICLE
Tianwen Wei, Yingqiang Du, Tiankai Shan, Jiawen Chen, Dongwei Shi, Tongtong Yang, Jiankang Wang, Jun Zhang, Yafei Li
Myocardial fibrosis, a common pathological manifestation of cardiac remodeling (CR), often leads to heart failure (HF) and even death. The underlying molecular mechanism of the role of TRIM33 in Ang II-induced myocardial fibrosis is not fully understood. We found that TRIM33 was specifically upregulated in CFs and myocardial tissue after Ang II stimulation. Adult mice induced by Ang II were used as in vivo models, and Ang II-induced neonatal mouse primary cardiac fibroblasts (CFs) were used as in vitro models...
April 2022: Bioengineered
https://read.qxmd.com/read/34985683/frankly-invasive-carcinoma-ex-intraductal-carcinoma-expanding-on-an-emerging-and-perplexing-concept-in-salivary-gland-tumor-pathology
#31
JOURNAL ARTICLE
Anne C McLean-Holden, Lisa M Rooper, Daniel J Lubin, Kelly R Magliocca, Varsha Manucha, Peter M Sadow, Jonathan Tobias, Richard J Vargo, Lester D R Thompson, Amin Heidarian, Ilan Weinreb, Bruce Wenig, Jeffrey Gagan, Juan C Hernandez-Prera, Justin A Bishop
Intraductal carcinoma (IDC) of the salivary glands is an uncommon and enigmatic tumor, our understanding of which is rapidly evolving. Recent studies have demonstrated multiple IDC subtypes and consistent gene fusions, most frequently involving RET. Because IDC is a ductal proliferation surrounded by flattened myoepithelial cells, it was previously presumed to be analogous to breast ductal carcinoma in situ, but recent evidence has shown that the myoepithelial cells of fusion-positive IDC harbor the same genetic alterations of the ductal cells and are therefore neoplastic...
September 2022: Head and Neck Pathology
https://read.qxmd.com/read/34926267/-sept6-_-trim33-gene-fusion-and-mutated-tp53-pathway-associate-with-unfavorable-prognosis-in-patients-with-b-cell-lymphomas
#32
JOURNAL ARTICLE
Haiying Fu, Huarong Zhou, Yanyan Qiu, Jianfei Wang, Zhiming Ma, Hongping Li, Feng Zhang, Chenxi Qiu, Jianzhen Shen, Tingbo Liu
Background: Mounting studies have sought to identify novel mutation biomarkers having diagnostic and prognostic potentials. Nevertheless, the understanding of the mutated pathways related to development and prognosis of B-cell lymphoma is still lacking. We aimed to comprehensively analyze the mutation alterations in genes of canonical signaling pathways and their impacts on the clinic outcomes of patients with B-cell lymphoma. Methods: Circulating cell-free DNA (cfDNA) samples from 79 patients with B-cell lymphomas were used for targeted sequencing with a 560-gene panel for depicting mutation landscapes and identifying gene fusion events...
2021: Frontiers in Oncology
https://read.qxmd.com/read/34719542/-aberrant-activation-mechanism-of-tgf-%C3%AE-signaling-in-epithelial-mesenchymal-transition
#33
JOURNAL ARTICLE
Ryuzaburo Yuki
Epithelial-mesenchymal transition (EMT) is an important program in epithelial cancer cells to acquire the motility and invasion, which promotes cancer metastasis to remote organs. EMT is induced by various secreted factors, such as transforming growth factor-β (TGF-β) and epidermal growth factor (EGF). TGF-β ligand activates Smad-dependent and -independent pathways by binding to TGF-β receptors. In Smad-dependent pathway, the activated TGF-β receptor phosphorylates Smad2/3 and accelerates its association with Smad4, leading to their nuclear translocation...
2021: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://read.qxmd.com/read/34392614/kat6a-acetylation-of-smad3-regulates-myeloid-derived-suppressor-cell-recruitment-metastasis-and-immunotherapy-in-triple-negative-breast-cancer
#34
JOURNAL ARTICLE
Bo Yu, Fei Luo, Bowen Sun, Wenxue Liu, Qiqi Shi, Shi-Yuan Cheng, Ceshi Chen, Guoqiang Chen, Yanxin Li, Haizhong Feng
Aberrant SMAD3 activation has been implicated as a driving event in cancer metastasis, yet the underlying mechanisms are still elusive. Here, SMAD3 is identified as a nonhistone substrate of lysine acetyltransferase 6A (KAT6A). The acetylation of SMAD3 at K20 and K117 by KAT6A promotes SMAD3 association with oncogenic chromatin modifier tripartite motif-containing 24 (TRIM24) and disrupts SMAD3 interaction with tumor suppressor TRIM33. This event in turn promotes KAT6A-acetylated H3K23-mediated recruitment of TRIM24-SMAD3 complex to chromatin and thereby increases SMAD3 activation and immune response-related cytokine expression, leading to enhanced breast cancer stem-like cell stemness, myeloid-derived suppressor cell (MDSC) recruitment, and triple-negative breast cancer (TNBC) metastasis...
August 13, 2021: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/34296745/transient-flexible-gene-editing-in-zebrafish-neutrophils-and-macrophages-for-determination-of-cell-autonomous-functions
#35
JOURNAL ARTICLE
Abdulsalam I Isiaku, Zuobing Zhang, Vahid Pazhakh, Harriet R Manley, Ella R Thompson, Lucy C Fox, Satwica Yerneni, Piers Blombery, Graham J Lieschke
Zebrafish are an important model for studying phagocyte function, but rigorous experimental systems to distinguish whether phagocyte-dependent effects are neutrophil or macrophage specific have been lacking. We have developed and validated transgenic lines that enable superior demonstration of cell-autonomous neutrophil and macrophage genetic requirements. We coupled well-characterized neutrophil- and macrophage-specific Gal4 driver lines with UAS:Cas9 transgenes for selective expression of Cas9 in either neutrophils or macrophages...
July 1, 2021: Disease Models & Mechanisms
https://read.qxmd.com/read/34101965/trim33-protects-osteoblasts-from-oxidative-stress-induced-apoptosis-in-osteoporosis-by-inhibiting-foxo3a-ubiquitylation-and-degradation
#36
JOURNAL ARTICLE
De-Bo Zou, Zongyou Mou, Wenliang Wu, Haichun Liu
This study aimed to probe into the effect of TRIM33 on oxidative stress-induced apoptosis of osteoblasts in osteoporosis and to probe into the underlying mechanism. The apoptosis of osteoblasts was induced by H2 O2 treatment and tested by flow cytometry. A mouse osteoporosis model was conducted by ovariectomy (OVX). The function of TRIM33 was assessed by in vitro and in vivo experiments. The mechanism of TRIM33 was determined by immunoprecipitation, immunofluorescent staining and co-transfection experiments...
June 8, 2021: Aging Cell
https://read.qxmd.com/read/33772100/analysis-of-human-total-antibody-repertoires-in-tif1%C3%AE-autoantibody-positive-dermatomyositis
#37
JOURNAL ARTICLE
Spyridon Megremis, Thomas D J Walker, Xiaotong He, James O'Sullivan, William E R Ollier, Hector Chinoy, Neil Pendleton, Antony Payton, Lynne Hampson, Ian Hampson, Janine A Lamb
We investigate the accumulated microbial and autoantigen antibody repertoire in adult-onset dermatomyositis patients sero-positive for TIF1γ (TRIM33) autoantibodies. We use an untargeted high-throughput approach which combines immunoglobulin disease-specific epitope-enrichment and identification of microbial and human antigens. We observe antibodies recognizing a wider repertoire of microbial antigens in dermatomyositis. Antibodies recognizing viruses and Poxviridae family species are significantly enriched...
March 26, 2021: Communications Biology
https://read.qxmd.com/read/33764396/trim33-gene-somatic-mutations-identified-by-next-generation-sequencing-in-neoplasms-of-patients-with-anti-tif1%C3%AE-positive-cancer-associated-dermatomyositis
#38
JOURNAL ARTICLE
Nadège Cordel, Céline Derambure, Sophie Coutant, Xavier Mariette, Denis Jullien, Sébastien Debarbieux, Olivier Chosidow, Alain Meyer, Didier Bessis, Pascal Joly, Alexis Mathian, Hervé Levesque, Jean-Christophe Sabourin, Isabelle Tournier, Olivier Boyer
OBJECTIVE: To deep sequence the TRIM33 gene in tumours from patients with cancer-associated anti-TIF1γ autoantibody-positive dermatomyositis (DM) as TRIM33 somatic mutations in tumours may trigger this auto-immune disease. METHODS: Next generation sequencing of tumour DNA samples from patients with cancer-associated anti-TIF1γ autoantibody-positive DM. Fourteen tumours from 13 anti-TIF1γ autoantibody-positive DM individuals were sequenced along with two control tumours from non-DM individuals...
December 1, 2021: Rheumatology
https://read.qxmd.com/read/33481220/alteration-of-trim33-expression-at-transcriptional-and-translational-levels-is-correlated-with-autism-symptoms
#39
JOURNAL ARTICLE
Sattar Norouzi Ofogh, Homa Rasoolijazi, Esmaeil Shahsavand Ananloo, Zahra Shahrivar, Mohammad Taghi Joghataei, Bahman Sadeghi, Ali Bozorgmehr, Fatemeh Alizadeh
As a complex neurodevelopmental disorder, autism affects children in three major cognitive domains including social interactions, language learning and repetitive stereotyped behaviors. Abnormal regulation of cell proliferation in the brain during the embryonic period via the TGF-β signaling pathway and TRIM33 gene that encodes a protein with a corepressor and regulatory role in this pathway has been considered as an etiology for autism. Here, we investigated the association of a variation of TRIM33 with autism symptoms at levels of mRNA and protein expression...
January 22, 2021: Journal of Molecular Neuroscience: MN
https://read.qxmd.com/read/33451684/integration-of-iga-and-igg-autoantigens-improves-performance-of-biomarker-panels-for-early-diagnosis-of-lung-cancer
#40
JOURNAL ARTICLE
Jianbo Pan, Lili Yu, Qingwei Wu, Xiaoqing Lin, Shuang Liu, Shaohui Hu, Christian Rosa, Daniel Eichinger, Ignacio Pino, Heng Zhu, Jiang Qian, Yi Huang
Lung cancer (LC) remains the leading cause of mortality from malignant tumors worldwide. In our previous study, we surveyed both IgG and IgM-bound serological biomarkers and validated a panel of IgG-bound autoantigens for early LC diagnosis with 50% sensitivity at 90% specificity. To further improve the performance of these serological biomarkers, we surveyed HuProt arrays, comprised of 20,240 human proteins, for IgA-bound autoantigens because IgAs are a major immunoglobulin isotype in the lung. Integrating with IgG-bound autoantigens, we discovered and validated a combined biomarker panel using ELISA-format tests...
March 2020: Molecular & Cellular Proteomics: MCP
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