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https://www.readbyqxmd.com/read/29216988/catheter-ablation-of-ventricular-tachycardia-in-structural-heart-disease-indications-strategies-and-outcomes-part-ii
#1
REVIEW
Srinivas R Dukkipati, Jacob S Koruth, Subbarao Choudry, Marc A Miller, William Whang, Vivek Y Reddy
In contrast to ventricular tachycardia (VT) that occurs in the setting of a structurally normal heart, VT that occurs in patients with structural heart disease carries an elevated risk for sudden cardiac death (SCD), and implantable cardioverter-defibrillators (ICDs) are the mainstay of therapy. In these individuals, catheter ablation may be used as adjunctive therapy to treat or prevent repetitive ICD therapies when antiarrhythmic drugs are ineffective or not desired. However, certain patients with frequent premature ventricular contractions (PVCs) or VT and tachycardiomyopathy should be considered for ablation before ICD implantation because left ventricular function may improve, consequently decreasing the risk of SCD and obviating the need for an ICD...
December 12, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29216987/catheter-ablation-of-ventricular-tachycardia-in-structurally-normal-hearts-indications-strategies-and-outcomes-part-i
#2
REVIEW
Srinivas R Dukkipati, Subbarao Choudry, Jacob S Koruth, Marc A Miller, William Whang, Vivek Y Reddy
Catheter ablation of ventricular tachycardia (VT) is being increasingly performed; yet, there is often confusion regarding indications, outcomes, and how to identify those patient populations most likely to benefit. The management strategy differs between those with structural heart disease and those without. For the former, an implantable cardioverter-defibrillator (ICD) is typically required due to an elevated risk for sudden cardiac death, and catheter ablation can be used as adjunctive therapy to treat or prevent repetitive ICD therapies...
December 12, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29214822/meeting-sleep-guidelines-is-associated-with-better-health-related-quality-of-life-and-reduced-premature-all-cause-mortality-risk
#3
Paul D Loprinzi, Chelsea Joyner
PURPOSE: To examine whether meeting sleep guidelines (7-9 hours/night) is associated with better health-related quality of life (HRQOL) and reduced all-cause mortality risk. DESIGN: Prospective cohort study. SETTING: 2005 to 2010 National Health and Nutrition Examination Survey. PARTICIPANTS: A total of 13 423 adults. MEASURES: Sleep duration and HRQOL were assessed from self-report; covariates assessed via survey, examination, and laboratory data; and mortality assessed through 2011 via matching from the National Death Index...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29213300/measuring-healthy-behaviours-using-the-stages-of-change-model-an-investigation-into-the-physical-activity-and-nutrition-behaviours-of-australian-miners
#4
Sarah J Lacey, Tamara D Street
Background: Obesity is one of the fastest growing modern day epidemics affecting preventable disease and premature deaths. Healthy lifestyle behaviours, such as physical activity and nutritional consumption, have been shown to reduce the likelihood of obesity and obesity related health risks. Originally designed for measurement of unhealthy behaviours, the Stages of Change model, describes 'precontemplators' as individuals who engage in the unhealthy behaviour, are unaware that their behaviour is problematic, and are resistant to change...
2017: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/29210136/identifying-acceptable-components-for-home-based-health-promotion-services-for-older-people-with-mild-frailty-a-qualitative-study
#5
Rachael Frost, Kalpa Kharicha, Ana Jovicic, Ann E M Liljas, Steve Iliffe, Jill Manthorpe, Benjamin Gardner, Christina Avgerinou, Claire Goodman, Vari M Drennan, Kate Walters
Mild frailty is common in later life, increasing the risk of hospitalisation, loss of independence and premature death. Targeted health promotion services may reduce adverse outcomes and increase quality of life; however, effective, well-developed theory-based interventions are lacking. We aimed to explore perceptions of health promotion behaviours undertaken by older people with mild frailty, barriers and facilitators to engagement, and identify potential components for new home-based health promotion services...
December 5, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29209460/association-of-dietary-patterns-with-overweight-risk-and-all-cause-mortality-in-children-with-cancer
#6
Eunjin So, Jeeyeon Kim, Sehwa Joo, Jisun Lee, Hyojee Joung
BACKGROUND/OBJECTIVES: This study aimed to investigate the association of dietary patterns with overweight risk and all-cause mortality in pediatric cancer patients. SUBJECTS/METHODS: Prospective cohort study was undertaken; 83 cancer patients admitted to the pediatric cancer ward at a university hospital in Seoul were included and followed for obesity and death over 24 months. Food consumption data were collected from patients using validated meal order sheets for breakfast, lunch, and dinner at the pediatric cancer ward over 3 days...
December 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29208858/correlation-of-troponin-i-level-with-left-ventricular-ejection-fraction-and-in-hospital-outcomes-after-first-attack-of-non-st-segment-elevation-myocardial-infarction
#7
M H Khan, M N Islam, G P Aditya, M Z Islam, A S Bhuiyan, B Saha, K Bhowmick, M Hassan, P K Paul, S Chowdhury, R Rahman
Coronary heart disease (CHD) is the most common cause of heart disease and is the single most important cause of premature death in developed world. Recognizing a patient with ACS is important because the diagnosis triggers both triage and management. cTnI is 100% tissue-specific for the myocardium and it has been shown to be a very sensitive and specific marker for acute myocardial infarction (AMI). Ventricular function is the best predictor of death after an acute coronary syndrome. It serves as a marker of myocardial damage, provides information on systolic function as well as diagnosis and prognosis...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29207788/hyperparathyroidism-during-pregnancy-a-diagnostic-and-therapeutic-challenge
#8
Richa Sharma, Bhanupriya, Vishnu Bhartiya, Kiran Guleria, Amita Suneja
Primary Hyperparathyroidism (PHP) is a rare event in pregnancy; Maternal complications in PHP patients can be as high as 67%. It can be overlooked easily because of many similar complaints shared by hyperparathyroidism and pregnancy such as nausea and vomiting, gastritis, bone aches, easy fatigability. Hypercalcemic crisis can develop resulting in coma and death. Neonatal effects are tetany and death in about 80% of cases. We report a case, of an antenatal woman at 30 weeks gestation with complains of painful swelling in left lower jaw and below right knee, pain over right hip joint and frequent episodes of gastritis...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207684/recurrent-glioma-clinical-trial-checkmate-143-the-game-is-not-over-yet
#9
REVIEW
Anna C Filley, Mario Henriquez, Mahua Dey
Glioblastoma (GBM) is the most common, and aggressive, primary brain tumor in adults. With a median patient survival of less than two years, GBM represents one of the biggest therapeutic challenges of the modern era. Even with the best available treatment, recurrence rates are nearly 100% and therapeutic options at the time of relapse are extremely limited. Nivolumab, an anti-programmed cell death-1 (PD-1) monoclonal antibody, has provided significant clinical benefits in the treatment of various advanced cancers and represented a promising therapy for primary and recurrent GBM...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207534/effects-of-the-macular-carotenoid-lutein-in-human-retinal-pigment-epithelial-cells
#10
Xiaoming Gong, Christian S Draper, Geoffrey S Allison, Raju Marisiddaiah, Lewis P Rubin
Retinal pigment epithelial (RPE) cells are central to retinal health and homoeostasis. Oxidative stress-induced damage to the RPE occurs as part of the pathogenesis of age-related macular degeneration and neovascular retinopathies (e.g., retinopathy of prematurity, diabetic retinopathy). The xanthophyll carotenoids, lutein and zeaxanthin, are selectively taken up by the RPE, preferentially accumulated in the human macula, and transferred to photoreceptors. These macular xanthophylls protect the macula (and the broader retina) via their antioxidant and photo-protective activities...
December 4, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29206474/trace-lithium-in-texas-tap-water-is-negatively-associated-with-all-cause-mortality-and-premature-death
#11
Val A Fajardo, Paul J LeBlanc, Val Andrei Fajardo
Lithium in tap water was previously found to have life-extending effects across 18 Japanese municipalities. Using a larger dataset with several Texas counties, our study shows that lithium concentrations in tap water are negatively associated with all-cause mortality (r = -0.18, p = 0.006, 232 counties) and years of potential life lost (r = -0.22, p = 0.001, 214 counties). Thus, our present findings extend and reinforce lithium's purported life-prolonging effect in humans.
December 5, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29203713/therapeutic-potential-of-heat-shock-protein-induction-for-muscular-dystrophy-and-other-muscle-wasting-conditions
#12
REVIEW
Savant S Thakur, Kristy Swiderski, James G Ryall, Gordon S Lynch
Duchenne muscular dystrophy is the most common and severe of the muscular dystrophies, a group of inherited myopathies caused by different genetic mutations leading to aberrant expression or complete absence of cytoskeletal proteins. Dystrophic muscles are prone to injury, and regenerate poorly after damage. Remorseless cycles of muscle fibre breakdown and incomplete repair lead to progressive and severe muscle wasting, weakness and premature death. Many other conditions are similarly characterized by muscle wasting, including sarcopenia, cancer cachexia, sepsis, denervation, burns, and chronic obstructive pulmonary disease...
January 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29201159/cardiovascular-risks-in-chronic-kidney-disease-pediatric-patients
#13
Jing Tian, Ling Niu, Xinjiang An
One of the common factors for the premature death in children is advanced chronic kidney disease (CKD). Most often cardiovascular disease (CVD) is the reason for mortality. The cardiovascular (CV) morbidity starts early in the disease process and renal transplanted children (CKD-T) are also at risk. The present review is focused on the current views of the cardiovascular risks during CKD in pediatric patients. Variable data sources for the latest literature collection were explored which mainly included PubMed and Google Scholar...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29200473/effect-of-premature-rupture-of-membranes-on-induction-of-labor-a-historical-cohort-study
#14
Sven Kehl, Christel Weiss, Ulf Dammer, Friederike Baier, Florian Faschingbauer, Matthias W Beckmann, Marc Sütterlin, Jutta Pretscher
Objective: The aim of this study was to assess the influence of premature rupture of membranes (PROM) on the induction of labor. Material and Method: This historical cohort study analyzed 1861 inductions of labor at term using misoprostol which occurred between 2010 and 2015. Exclusion criteria included intrauterine fetal death, previous cesarean section, and fetal structural or chromosomal anomalies. Induction of labor for PROM (PROM group) was compared to induction for other indications (no-PROM group); the primary outcome measure was the cesarean section rate...
November 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29198532/impact-of-prolonged-mechanical-ventilation-in-very-low-birth-weight-infants-results-from-a-national-cohort-study
#15
Young-Bin Choi, Juyoung Lee, Jisun Park, Yong Hoon Jun
OBJECTIVE: To evaluate the in-hospital consequences of prolonged respiratory support with invasive mechanical ventilation in very low birth weight infants. STUDY DESIGN: A cohort study was performed using prospectively collected data from 69 neonatal intensive care units participating in the Korean national registry. In total, 3508 very low birth weight infants born between January 1, 2013 and December 31, 2014 were reviewed. RESULTS: The adjusted hazard ratio for death increased significantly for infants who received mechanical ventilation for more than 2 weeks compared with those were mechanically ventilated for 7 days or less...
November 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29196880/role-of-intestinal-hsp70-in-barrier-maintenance-contribution-of-milk-to-the-induction-of-hsp70-2
#16
Rebecca M Rentea, Yuee Guo, Xiaorong Zhu, Mark W Musch, Eugene B Chang, David M Gourlay, Jennifer L Liedel
BACKGROUND: Necrotizing enterocolitis (NEC) is a gastrointestinal disease of complex etiology resulting in devastating systemic inflammation and often death in premature newborns. We previously demonstrated that formula feeding inhibits ileal expression of heat shock protein-70 (Hsp70), a critical stress protein within the intestine. Barrier function for the premature intestine is critical. We sought to determine whether reduced Hsp70 protein expression increases neonatal intestinal permeability...
December 1, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29193226/generic-daclatasvir-plus-sofosbuvir-with-or-without-ribavirin-in-treatment-of-chronic-hepatitis-c-real-world-results-from-18-378-patients-in-egypt
#17
H Omar, W El Akel, T Elbaz, M El Kassas, K Elsaeed, H El Shazly, M Said, M Yousif, A A Gomaa, A Nasr, M AbdAllah, M Korany, S A Ismail, M K Shaker, W Doss, G Esmat, I Waked, Y El Shazly
BACKGROUND: Treatment of chronic hepatitis C using combination of sofosbuvir (SOF) and daclatasvir (DCV) was used in several clinical trials and multicentre studies, which were somewhat limited to genotypes 1-3. The national program in Egypt is using SOF-DCV combination for large scale treatment. AIM: To assess the efficacy and safety of combined SOF-DCV in treating patients with HCV-G4 in a real-world setting. METHODS: Data and outcome of chronic HCV patients who were treated for 12 weeks with generic medications: DCV 60 mg plus SOF 400 mg ± ribavirin (RBV) within the national hepatitis C treatment program in Egypt are presented...
November 29, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29193044/accumulation-of-rest-deficiency-precedes-sudden-death-of-epileptic-kv1-1-knockout-mice-a-model-of-sudden-unexpected-death-in-epilepsy
#18
Shruthi H Iyer, Stephanie A Matthews, Timothy A Simeone, Rama Maganti, Kristina A Simeone
OBJECTIVE: Chronic sleep deficiency is associated with early mortality. In the epileptic population, there is a higher prevalence of sleep disorders, and individuals with severe refractory epilepsy are at greater risk of premature mortality than the general population. Sudden unexpected death in epilepsy affects 1:1000 cases of epilepsy each year. Ketogenic diet (KD) treatment is one of the few effective options for refractory seizures. Despite KD reducing seizures and increasing longevity in Kv1...
November 28, 2017: Epilepsia
https://www.readbyqxmd.com/read/29190573/common-comorbidities-and-survival-in-ms-risk-for-stroke-type-1-diabetes-and-infections
#19
A Murtonen, S Kurki, K Hänninen, M Soilu-Hänninen, M-L Sumelahti
BACKGROUND: Survival in MS has increased during the era of disease modifying therapies, but life expectancy in MS patients is still reduced by several years. Increased risk for common comorbidities related to brain health, such as risk for circulatory diseases have been reported in MS and could affect survival. In this paper, we studied age- and gender adjusted risks for circulatory diseases and related disorders, and their impact on overall MS survival in population of Southwest Finland...
November 13, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29188029/distributional-benefits-of-tobacco-tax-and-smoke-free-workplaces-in-china-a-modeling-study
#20
Stéphane Verguet, Gillian Tarr, Cindy L Gauvreau, Sujata Mishra, Prabhat Jha, Lingrui Liu, Yue Xiao, Yingpeng Qiu, Kun Zhao
Background: Tobacco taxation and smoke-free workplaces reduce smoking, tobacco-related premature deaths and associated out-of-pocket health care expenditures. We examine the distributional consequences of a price increase in tobacco products through an excise tax hike, and of an implementation of smoke-free workplaces, in China. Methods: We use extended cost-effectiveness analysis (ECEA) to evaluate, across income quintiles of the male population (the large majority of Chinese smokers), the premature deaths averted, the change in tax revenues generated, and the financial risk protection procured (eg, poverty cases averted, defined as the number of individuals no longer facing tobacco-related out-of-pocket expenditures for disease treatment, that would otherwise impoverish them), that would follow a 75% increase in cigarette prices through substantial increments in excise tax fully passed onto consumers, and a nationwide total implementation of workplace smoking bans...
December 2017: Journal of Global Health
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