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Premature death

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https://www.readbyqxmd.com/read/29049359/analysis-of-pd-1-expression-in-the-monocyte-subsets-from-non-septic-and-septic-preterm-neonates
#1
Magdalena Zasada, Marzena Lenart, Magdalena Rutkowska-Zapała, Małgorzata Stec, Wojciech Durlak, Andrzej Grudzień, Agnieszka Krzeczkowska, Nina Mól, Marta Pilch, Maciej Siedlar, Przemko Kwinta
Programmed death-1 (PD-1) receptor system represents a part of recently reported immunoregulatory pathway. PD-1 is an immune checkpoint molecule, which plays an important role in downregulating the immune system proinflammatory activity. Until recently, PD-1 expression was not established on immune cells of the preterm infants. The study objectives were to confirm expression of the PD-1 receptors on the monocytes isolated from very low birth weight newborns (VLBW), and to analyze their expression during the first week of life and late-onset sepsis...
2017: PloS One
https://www.readbyqxmd.com/read/29048409/maternal-milk-feedings-reduce-sepsis-necrotizing-enterocolitis-and-improve-outcomes-of-premature-infants
#2
J Cortez, K Makker, D F Kraemer, J Neu, R Sharma, M L Hudak
OBJECTIVE: Human milk (donor milk (DM) and/or maternal milk (MM)) feedings protect against late onset sepsis (LOS), necrotizing enterocolitis (NEC) and death. However, DM lacks many anti-infective components of MM. Therefore, we studied exclusive MM feedings to evaluate the full effect of human milk on infectious and other outcomes in premature infants. STUDY DESIGN: All infants born before 33 weeks postmenstrual age (PMA) who received exclusive (>95%) MM or exclusive preterm formula (PF) were included in this prospective investigation...
October 19, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29048385/disease-and-health-inequalities-attributable-to-air-pollutant-exposure-in-detroit-michigan
#3
Sheena E Martenies, Chad W Milando, Guy O Williams, Stuart A Batterman
The environmental burden of disease is the mortality and morbidity attributable to exposures of air pollution and other stressors. The inequality metrics used in cumulative impact and environmental justice studies can be incorporated into environmental burden studies to better understand the health disparities of ambient air pollutant exposures. This study examines the diseases and health disparities attributable to air pollutants for the Detroit urban area. We apportion this burden to various groups of emission sources and pollutants, and show how the burden is distributed among demographic and socioeconomic subgroups...
October 19, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29047384/enhancing-evidence-based-diabetes-and-chronic-disease-control-among-local-health-departments-a-multi-phase-dissemination-study-with-a-stepped-wedge-cluster-randomized-trial-component
#4
Renee G Parks, Rachel G Tabak, Peg Allen, Elizabeth A Baker, Katherine A Stamatakis, Allison R Poehler, Yan Yan, Marshall H Chin, Jenine K Harris, Maureen Dobbins, Ross C Brownson
BACKGROUND: The rates of diabetes and prediabetes in the USA are growing, significantly impacting the quality and length of life of those diagnosed and financially burdening society. Premature death and disability can be prevented through implementation of evidence-based programs and policies (EBPPs). Local health departments (LHDs) are uniquely positioned to implement diabetes control EBPPs because of their knowledge of, and focus on, community-level needs, contexts, and resources. There is a significant gap, however, between known diabetes control EBPPs and actual diabetes control activities conducted by LHDs...
October 18, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/29047100/mitochondrial-and-metabolic-drivers-of-pulmonary-vascular-endothelial-dysfunction-in-pulmonary-hypertension
#5
Qiujun Yu, Stephen Y Chan
Pulmonary hypertension (PH) is a deadly and increasingly prevalent vascular disease characterized by excessive pulmonary vascular remodeling and right ventricular dysfunction which leads to right heart failure, multiorgan dysfunction, and premature death. The cause of the vascular remodeling in PH remains elusive, and thus current treatments are marginally effective and prognosis of PH remains poor. Increasing evidence indicates the pathogenic importance of endothelial dysfunction in PH. However, the underlying mechanisms of such dysfunction are not well described...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29046785/educational-inequalities-in-premature-mortality-by-region-in-the-belgian-population-in-the-2000s
#6
Françoise Renard, Brecht Devleesschauwer, Sylvie Gadeyne, Jean Tafforeau, Patrick Deboosere
BACKGROUND: In Belgium, socio-economic inequalities in mortality have long been described at country-level. As Belgium is a federal state with many responsibilities in health policies being transferred to the regional levels, regional breakdown of health indicators is becoming increasingly relevant for policy-makers, as a tool for planning and evaluation. We analyzed the educational disparities by region for all-cause and cause-specific premature mortality in the Belgian population. METHODS: Residents with Belgian nationality at birth registered in the census 2001 aged 25-64 were included, and followed up for 10 years though a linkage with the cause-of-death database...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29046161/inhaled-nitric-oxide-in-preterm-neonates-with-refractory-hypoxemia-associated-to-oligohydramnios
#7
Alvarado Socarras Jorge, Castro M Javier, Fredi Alexander Diaz-Quijano
BACKGROUND: Therapy with inhaled nitric oxide (iNO) is effective in the management of pulmonary hypertension and severe hypoxemia. However, these benefits have not been demonstrated in preterm infants (<34 weeks). The objective of this report is to present the experience of eight cases of preterm neonates with respiratory distress syndrome (RDS) and refractory hypoxemia, with oligohydramnios history. METHODS: We evaluated the clinical feature of 8 preterm neonates with severe hypoxemia who had maternal antecedents of oligoamnios, mainly due to premature rupture of membranes...
October 17, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29045045/mesenchymal-stromal-cell-therapy-in-bronchopulmonary-dysplasia-systematic-review-and-meta-analysis-of-preclinical-studies
#8
Sajit Augustine, Marc T Avey, Brittany Harrison, Tiffany Locke, Mona Ghannad, David Moher, Bernard Thébaud
Extreme prematurity is the leading cause of death among children under 5 years of age. Currently, there is no treatment for bronchopulmonary dysplasia (BPD), the most common complication of extreme prematurity. Experimental studies in animal models of BPD suggest that mesenchymal stromal cells (MSCs) are lung protective. To date, no systematic review and meta-analysis has evaluated the preclinical evidence of this promising therapy. Our protocol was registered with Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies prior to searching MEDLINE (1946 to June 1, 2015), Embase (1947 to 2015 Week 22), Pubmed, Web of Science, and conference proceedings (1990 to present) for controlled comparative studies of neonatal animal models that received MSCs or cell free MSC-derived conditioned media (MSC-CM)...
October 17, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29044036/-five-decades-of-coronary-artery-disease-in-iceland-data-from-the-icelandic-heart-association
#9
Karl Andersen, Thor Aspelund, Elías Freyr Gudmundsson, Kristin Siggeirsdottir, Rosa Bjork Thorolfsdottir, Gunnar Sigurdsson, Vilmundur Gudnason
Coronary artery disease has been the leading cause of death and disability in Iceland during the past decades although in recent years, malignancy has taken over that position. A steady improvement in the level of major risk factors has been evident since 1980. This trend explains 72% of the decrease in premature mortality from coronary artery disease during the past three decades. However, an opposing trend in increasing obesity and type 2 diabetes has attenuated this decline in premature deaths. Unchanged risk factor trends will lead to increasing cardiovascular mortality in the years to come...
October 2017: Læknablađiđ
https://www.readbyqxmd.com/read/29042427/predictors-of-death-in-adults-with-duchenne-muscular-dystrophy-associated-cardiomyopathy
#10
Daniel Cheeran, Shaida Khan, Rohan Khera, Anish Bhatt, Sonia Garg, Justin L Grodin, Robert Morlend, Faris G Araj, Alpesh A Amin, Jennifer T Thibodeau, Sandeep Das, Mark H Drazner, Pradeep P A Mammen
BACKGROUND: Duchenne muscular dystrophy (DMD) is frequently complicated by development of a cardiomyopathy. Despite significant medical advances provided to DMD patients over the past 2 decades, there remains a group of DMD patients who die prematurely. The current study sought to identify a set of prognostic factors that portend a worse outcome among adult DMD patients. METHODS AND RESULTS: A retrospective cohort of 43 consecutive patients was followed in the adult UT Southwestern Neuromuscular Cardiomyopathy Clinic...
October 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29042423/low-prevalence-of-inappropriate-shocks-in-patients-with-inherited-arrhythmia-syndromes-with-the-subcutaneous-implantable-defibrillator-single-center-experience-and-long-term-follow-up
#11
Boris Rudic, Erol Tülümen, Veronika Berlin, Susanne Röger, Ksenija Stach, Volker Liebe, Ibrahim El-Battrawy, Christina Dösch, Theano Papavassiliu, Ibrahim Akin, Martin Borggrefe, Jürgen Kuschyk
BACKGROUND: Up to 40% of patients with transvenous implantable cardioverter-defibrillator (ICD) experience lead-associated complications and may suffer from high complication rates when lead extraction is indicated. Subcutaneous ICD may represent a feasible alternative; however, the efficacy of the subcutaneous ICD in the detection and treatment of ventricular arrhythmias in patients with hereditary arrhythmia syndromes has not been fully evaluated. METHODS AND RESULTS: Patients with primary hereditary arrhythmia syndromes who fulfilled indication for defibrillator placement were eligible for enrollment...
October 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29040950/green-spaces-are-not-all-the-same-for-the-provision-of-air-purification-and-climate-regulation-services-the-case-of-urban-parks
#12
Joana Vieira, Paula Matos, Teresa Mexia, Patrícia Silva, Nuno Lopes, Catarina Freitas, Otília Correia, Margarida Santos-Reis, Cristina Branquinho, Pedro Pinho
The growing human population concentrated in urban areas lead to the increase of road traffic and artificial areas, consequently enhancing air pollution and urban heat island effects, among others. These environmental changes affect citizen's health, causing a high number of premature deaths, with considerable social and economic costs. Nature-based solutions are essential to ameliorate those impacts in urban areas. While the mere presence of urban green spaces is pointed as an overarching solution, the relative importance of specific vegetation structure, composition and management to improve the ecosystem services of air purification and climate regulation are overlooked...
October 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/29040557/divergence-and-convergence-in-cause-specific-premature-adult-mortality-in-mexico-and-us-mexican-hispanics-from-1995-to-2015-analyses-of-4-9-million-individual-deaths
#13
Luz Myriam Reynales-Shigematsu, Carlos Manuel Guerrero-López, Mauricio Hernández Ávila, Hyacinth Irving, Prabhat Jha
Background: Mexicans and US Mexican Hispanics share modifiable determinants of premature mortality. We compared trends in mortality at ages 30-69 in Mexico and among US Mexican Hispanics from 1995 to 2015. Methods: We examined nationally representative statistics on 4.2 million Mexican and 0.7 million US deaths to examine cause-specific mortality. We used lung cancer indexed methods to estimate smoking-attributable deaths stratified by high and lower burden Mexican states...
September 23, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29039624/factors-associated-with-cessation-of-smoking-among-swiss-adults-between-1991-and-2011-results-from-the-sapaldia-cohort
#14
Diana Ayala-Bernal, Nicole Probst-Hensch, Thierry Rochat, Robert Bettschart, Otto Brändli, Pierre-Olivier Bridevaux, Luc Burdet, Martin Frey, Margaret Gerbase, Marco Pons, Thomas Rothe, Daiana Stolz, Jean-Marie Tschopp, Alexander Turk, Nino Künzli, Christian Schindler
INTRODUCTION: Smoking is still the most preventable cause of disease and premature death in Switzerland, as elsewhere. We aimed to assess the main determinants of smoking cessation in the population-based cohort of SAPALDIA (Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults). METHODS: The SAPALDIA study was initiated in 1991 with 9651 participants aged 18 to 60 years from eight areas (S1). Follow-up assessments were conducted in 2002 (S2; 8047 participants) and 2010/11 (S3; 6088 participants)...
October 17, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29039551/upregulation-of-rho7-in-the-temporal-lobe-tissue-of-humans-with-intractable-epilepsy
#15
Xinglong Yang, Baiyuan Yang, Haonan Li, Hui Ren
Patients with intractable epilepsy (IE) exhibit an increased risk of premature death, psychosocial dysfunction and decreasing quality of life. The present study aimed to investigate the alteration in the expression of Rho7 in brain tissue from patients with IE, and to examine the association between Rho7 protein expression and IE. Temporal lobe samples were collected from the temporal lobes of 33 patients with IE patients and 10 age‑ and gender‑matched histologically healthy controls. Immunohistochemical staining was conducted to assess the number of Rho7‑positive cells...
October 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29038823/left-ventricular-twist-in-hypertrophic-cardiomyopathy-predictor-of-nonsustained-ventricular-tachycardia
#16
O Candan, C Gecmen, A Kalaycı, E Bayam, A Guner, S Gunduz, S Cersit, M Ozkan
BACKGROUND: We investigated the efficacy of clinical and classic echocardiographic parameters in predicting the occurrence of nonsustained ventricular tachycardia (NsVT) in patients with hypertrophic cardiomyopathy (HCM). METHODS: The study comprised 59 patients with HCM (47 male, [80%]; mean age, 48.48 ± 14.16 years). Clinical, electrocardiographic, as well as classic two-dimensional and speckle-tracking echocardiography (STE) data were collected. All patients had Holter monitoring within 24-72 h of the echocardiographic examination...
October 16, 2017: Herz
https://www.readbyqxmd.com/read/29038314/physical-activity-reduces-risk-of-premature-mortality-in-patients-with-type-1-diabetes-with-and-without-kidney-disease
#17
Heidi Tikkanen-Dolenc, Johan Wadén, Carol Forsblom, Valma Harjutsalo, Lena M Thorn, Markku Saraheimo, Nina Elonen, Heikki O Tikkanen, Per-Henrik Groop
OBJECTIVE: The aims of the study were to assess how baseline leisure-time physical activity (LTPA) and its exercise components intensity, duration, and frequency are associated with all-cause and cardiovascular mortality in patients with type 1 diabetes 1) overall, 2) stratified by presence or absence of chronic kidney disease (CKD), and 3) stratified by sex. RESEARCH DESIGN AND METHODS: The study design was prospective and observational and included 2,639 patients with type 1 diabetes from the ongoing nationwide multicenter Finnish Diabetic Nephropathy (FinnDiane) Study...
October 16, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29037163/diagnostic-performance-of-various-familial-hypercholesterolaemia-diagnostic-criteria-compared-to-dutch-lipid-clinic-criteria-in-an-asian-population
#18
Suraya Abdul-Razak, Radzi Rahmat, Alicezah Mohd Kasim, Thuhairah Abdul Rahman, Suhaila Muid, Nadzimah Mohd Nasir, Zubin Ibrahim, Sazzli Kasim, Zaliha Ismail, Rohana Abdul Ghani, Abdul Rais Sanusi, Azhari Rosman, Hapizah Nawawi
BACKGROUND: Familial hypercholesterolaemia (FH) is a genetic disorder with a high risk of developing premature coronary artery disease that should be diagnosed as early as possible. Several clinical diagnostic criteria for FH are available, with the Dutch Lipid Clinic Criteria (DLCC) being widely used. Information regarding diagnostic performances of the other criteria against the DLCC is scarce. We aimed to examine the diagnostic performance of the Simon-Broom (SB) Register criteria, the US Make Early Diagnosis to Prevent Early Deaths (US MEDPED) and the Japanese FH Management Criteria (JFHMC) compared to the DLCC...
October 16, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29037154/an-inappropriate-pacing-threshold-increase-after-repeated-electrical-storm-in-a-patient-with-implantable-cardioverter-defibrillator
#19
Ye Zhu, Xiang Gu, Chao Xu
BACKGROUND: Implantable cardioverter defibrillators (ICD) are capable of effectively terminating malignant ventricular arrhythmia and are the most effective way to prevent sudden cardiac death. However, some evidences demonstrated that both anti-tachycardia pacing (ATP) and ICD shock can also bring adverse prognosis. CASE PRESENTATION: A 66-year-old Han Chinese man with prior ICD implantation was admitted to our hospital because of frequent ICD shocks. Although intravenous amiodarone and esmolol succinate were administered daily, the patient suffered 155 episodes of VT/VF during 8 weeks after implantation...
October 16, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29035425/inhaled-versus-systemic-corticosteroids-for-the-treatment-of-bronchopulmonary-dysplasia-in-ventilated-very-low-birth-weight-preterm-infants
#20
REVIEW
Sachin S Shah, Arne Ohlsson, Henry L Halliday, Vibhuti S Shah
BACKGROUND: This is an update of a review published in 2012. A related review "Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates" has been updated as well. Bronchopulmonary dysplasia (BPD) is a serious and common problem among very low birth weight infants, despite the use of antenatal steroids and postnatal surfactant therapy to decrease the incidence and severity of respiratory distress syndrome. Due to their anti-inflammatory properties, corticosteroids have been widely used to treat or prevent BPD...
October 16, 2017: Cochrane Database of Systematic Reviews
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