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https://www.readbyqxmd.com/read/28910257/between-a-rock-and-a-hard-place-prescription-opioid-restrictions-in-the-time-of-fentanyl-and-other-street-drug-adulterants
#1
Tessa Cheng, Kora DeBeck
Non-medical prescription opioid use (NMPOU) has increased alarmingly across Canada and resulted in strict prescribing restrictions on opioids. Despite a clear need to reduce opioid prescriptions in response to this crisis, few other policies have been implemented and this singular focus is incongruent with the known characteristics of substance use disorders, negative effects of supply reduction policies, and realities of pain management. Given the recent rise of fentanyl and other dangerous adulterants in street drugs, this commentary argues that a comprehensive response to NMPOU that includes improvements to addiction management and harm-reduction services is urgently needed...
September 14, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28910177/development-and-validation-of-a-brief-measure-of-eating-compulsivity-mec
#2
Ria Schroder, John Douglas Sellman, Simon Adamson
Food addiction is increasingly being recognised as a contributory factor in overweight and obesity. Management of eating compulsivity, a key component of food addiction, may assist greatly in the successful treatment of obesity. Measurement of food addiction and its core characteristic of eating compulsivity is fundamental to increasing understandings of the concept of food addiction, its prevalence among people with and without obesity and its utility within a treatment context. The current study describes the development and initial validation of a brief measure of eating compulsivity that can be used within clinical and research settings to establish a person's level of eating compulsivity...
September 14, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28894547/a-novel-therapy-for-cocaine-dependence-during-abstinence-a-randomized-clinical-trial
#3
Bijan Pirnia, Ali Reza Moradi, Kambiz Pirnia, Parisa Kolahi, Rasool Roshan
BACKGROUND: Topiramate is an anticonvulsant drug and an ideal candidate for reducing the craving in people relying on cocaine. Contingency management is one of the common therapies in the domain of addiction. OBJECTIVE: The present study aimed to evaluate and compare three medication methods of Topiramate (TPM), Contingency Management (CM) and the combined TPM treatment and cash intervention on craving during abstinence. METHODS: This randomized clinical trial was conducted at Bijan Center for Substance Abuse Treatment in Tehran, Iran, from December 15, 2014 to November 20, 2015...
July 2017: Electronic Physician
https://www.readbyqxmd.com/read/28893589/leptin-status-alters-buprenorphine-induced-antinociception-in-obese-mice-with-dysfunctional-leptin-receptors
#4
Zachary Glovak, Sara Mihalko, Helen A Baghdoyan, Ralph Lydic
Buprenorphine is an opiate used for pain management and to treat opiate addiction. The cytokine leptin can modulate nociception, but the extent to which buprenorphine-induced antinociception varies as a function of leptin signaling has not been characterized. Four congenic mouse lines with phenotypes that include differences in body weight and leptin status were used to test the hypothesis that the antinociceptive effects of buprenorphine vary as function of sex and leptin signaling. Each mouse line was comprised of males (n=12) and females (n=12) for a total of 96 animals...
September 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28889218/opioid-use-following-gynecologic-and-pelvic-reconstructive-surgery
#5
Lekha S Hota, Hussein A Warda, Miriam J Haviland, Frances M Searle, Michele R Hacker
INTRODUCTION AND HYPOTHESIS: Opioid use, addiction, and overdose are a growing epidemic in the USA. Our objective was to determine whether the amount of opioid medication prescribed following gynecologic and pelvic reconstructive surgery is insufficient, adequate, or in excess. We hypothesized that we were overprescribing postoperative opioids. METHODS: Participants who were at least 18 years old and underwent gynecologic and/or pelvic reconstructive surgery from April through August 2016 were eligible to participate...
September 9, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28889212/cocaine-like-discriminative-stimulus-effects-of-norepinephrine-preferring-monoamine-releasers-time-course-and-interaction-studies-in-rhesus-monkeys
#6
Stephen J Kohut, David S Jacobs, Richard B Rothman, John S Partilla, Jack Bergman, Bruce E Blough
RATIONALE: The therapeutic potential of monoamine releasers with prominent dopaminergic effects is hindered by their high abuse liability. OBJECTIVES: The present study examined the effects of several novel "norepinephrine (NE)-preferring" monoamine releasers relative to non-selective monoamine releasers, d-amphetamine and d-methamphetamine, in rhesus monkeys trained to discriminate cocaine. NE-preferring releasers were approximately 13-fold more potent for NE compared to dopamine release and ranged in potency for serotonin release (PAL-329 < l-methamphetamine < PAL-169)...
September 9, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28886671/canadian-schizophrenia-guidelines-schizophrenia-and-other-psychotic-disorders-with-coexisting-substance-use-disorders
#7
David Crockford, Donald Addington
OBJECTIVE: Persons with schizophrenia and other psychotic disorders frequently have coexisting substance use disorders that require modifications to treatment approaches for best outcomes. The objectives of this review were to identify evidence-based practices best practices that improve outcomes for individuals with schizophrenia and substance used disorders. METHOD: We reviewed guidelines that were published in the last 5 years and that included systematic reviews or meta-analyses...
September 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28885516/treating-acute-pain-in-the-opiate-dependent-patient
#8
Coleen Dever
Opioid drugs, including prescription as well as heroin, have come to the national spotlight due to the unprecedented rate of overdose and addiction. The Centers for Disease Control and Prevention (CDC) has termed this problem as an "epidemic" that has reached record numbers of deaths in 2014. Approximately half of these deaths are the result from prescribed opioids. Also on the rise are the numbers of individuals who are diagnosed with chronic pain and are treated with opioids, methadone and buprenorphine. Individuals currently taking opioids for chronic pain confound the treatment of acute pain after traumatic injury...
September 2017: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/28885359/sustained-dysfunctional-information-processing-in-patients-with-internet-gaming-disorder-6-month-follow-up-erp-study
#9
Minkyung Park, Yeon Jin Kim, Dai Jin Kim, Jung-Seok Choi
Internet gaming disorder (IGD), defined as an inability to control Internet-based game play, leads to serious impairment in psychological and social functioning, but few studies have identified the neurophysiological characteristics of patients with IGD. The aim of this study was to determine neurophysiological markers of P300 components associated with changes in symptoms after outpatient management with pharmacotherapy in patients with IGD. The present prospective longitudinal study included 18 patients with IGD and 29 healthy controls...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28872364/can-cyberloafing-and-internet-addiction-affect-organizational-information-security
#10
Lee Hadlington, Kathryn Parsons
Researchers have noted potential links between Internet addiction, the use of work computers for nonwork purposes and an increased risk of threat to the organization from breaches in cybersecurity. However, much of this research appears conjectural in nature and lacks clear empirical evidence to support such claims. To fill this knowledge gap, a questionnaire-based study explored the link between cyberloafing, Internet addiction, and information security awareness (ISA). A total of 338 participants completed an online questionnaire, which comprised of the Online Cognition Scale, Cyberloafing Scale, and the Human Aspects of Information Security Questionnaire...
September 5, 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/28868576/choice-between-delayed-food-and-immediate-opioids-in-rats-treatment-effects-and-individual-differences
#11
Leigh V Panlilio, Maria E Secci, Charles W Schindler, Charles W Bradberry
RATIONALE: Addiction involves maladaptive choice behavior in which immediate drug effects are valued more than delayed nondrug rewards. OBJECTIVES AND METHODS: To model this behavior and extend our earlier work with the prescription opioid oxycodone, we allowed rats to choose between immediate intravenous delivery of the short-acting opioid remifentanil and delayed delivery of highly palatable food pellets. Treatment drugs were tested on a baseline where remifentanil was preferred over food...
September 4, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28864706/contingency-management-for-tobacco-smoking-during-opioid-addiction-treatment-a-randomised-pilot-study
#12
Tom Stephen Ainscough, Leonie S Brose, John Strang, Ann McNeill
INTRODUCTION: Smoking rates among individuals in treatment for opioid addiction are close to five times that of the general public. Moreover, drug-addicted smokers have a premature mortality rate four times greater than drug-addicted non-smokers. The aim of this pilot study was to investigate whether contingency management (CM) can be successfully added to evidence-based stop smoking treatment in individuals undergoing treatment for opioid addiction and assess preliminary evidence for its impact...
September 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28861513/prevalence-and-correlates-of-cannabis-use-in-outpatients-with-serious-mental-illness-receiving-treatment-for-alcohol-use-disorders
#13
Jordan Skalisky, Emily Leickly, Oladunni Oluwoye, Sterling M McPherson, Debra Srebnik, John M Roll, Richard K Ries, Michael G McDonell
Introduction: People with serious mental illness (SMI) use cannabis more than any other illicit drug. Cannabis use is associated with increased psychotic symptoms and is highly comorbid with alcohol use disorders (AUDs). Despite the national trend toward decriminalization, little is known about the prevalence, correlates, and impact of cannabis use on those with SMI receiving treatment for substance use disorders, a group at high risk for the negative effects of cannabis use. Methods: In this secondary data analysis, cannabis use prevalence, correlates, and impact on treatment outcomes were examined in 121 adults with cooccurring SMI and AUDs receiving outpatient addiction treatment in a randomized trial of contingency management (CM) for alcohol...
2017: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/28860849/cancer-pain-management-in-china-current-status-and-practice-implications-based-on-the-acheon-survey
#14
Zhongjun Xia
PURPOSE: Cancer pain can seriously impact the quality of life (QoL) of patients, and optimal management practices are therefore of paramount importance. The ACHEON survey queried physicians and patients from 10 Asian countries/regions to assess current clinical practices in cancer pain management in Asia. This study presents the data obtained for cancer pain management in mainland China, with an emphasis on practices related to opioid drugs. MATERIALS AND METHODS: In several tertiary hospitals across China, 250 patients experiencing cancer pain and 100 physicians were surveyed on questions designed to assess current cancer pain management practices and cancer pain impact on QoL...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28852234/relationship-of-anger-with-alcohol-use-treatment-outcome-follow-up-study
#15
Manoj Kumar Sharma, L N Suman, Pratima Murthy, P Marimuthu
BACKGROUND: Anger is seen as comorbid condition in psychiatric conditions. It has an impact on one's quality of life. It leads to variation in the treatment outcome. The present study is going to explore the relationship of anger with treatment outcome among alcohol users after 1 year of treatment. The data for the present study were taken from the project work on correlates of anger among alcohol users, funded by center for addiction medicine, NIMHANS, Bengaluru, Karnataka, India. MATERIALS AND METHODS: A total of 100 males (50 alcohol-dependent and 50 abstainers) in the age range of 20-45 years with a primary diagnosis of alcohol dependence were taken for the study...
July 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28843358/brief-report-baseline-and-on-treatment-characteristics-of-serum-tumor-markers-in-stage-iv-oncogene-addicted-adenocarcinoma-of-the-lung
#16
Sinead A Noonan, Tejas Patil, Dexiang Gao, Gentry G King, Jessica R Thibault, Xian Lu, Paul A Bunn, Robert C Doebele, W Thomas Purcell, Anna E Barón, D Ross Camidge
INTRODUCTION: The role of serum tumor markers in the modern management of advanced non-small cell lung cancer remains poorly described. METHODS: A single center retrospective analysis of available CEA, CA125, CA19.9 and CA27.29 levels at baseline and on treatment in stage IV lung adenocarcinoma by oncogenic driver was conducted. RESULTS: 142 patients were analyzed (ALK=60, EGFR=50, ROS1=4 and KRAS=28). 82% of patients had at least one marker; 95% if all four markers measured (CA27...
August 23, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28839515/addictive-behaviors-in-liver-transplant-recipients-the-real-problem
#17
REVIEW
Hélène Donnadieu-Rigole, Pascal Perney, José Ursic-Bedoya, Stéphanie Faure, Georges-Philippe Pageaux
Liver transplantation (LT) is the gold standard treatment for end-stage liver disease. Whatever the primary indication of LT, substance abuse after surgery may decrease survival rates and quality of life. Prevalence of severe alcohol relapse is between 11 and 26%, and reduces life expectancy regardless of the primary indication of LT. Many patients on waiting lists for LT are smokers and this is a major risk factor for both malignant tumors and cardiovascular events post-surgery. The aim of this review is to describe psychoactive substance consumption after LT, and to assess the impact on liver transplant recipients...
August 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28836711/delirium-tremens-and-alcohol-withdrawal-nationally-in-the-veterans-health-administration
#18
David Thomas Moore, Brian Scott Fuehrlein, Robert Alan Rosenheck
BACKGROUND AND OBJECTIVES: Alcohol withdrawal-especially delirium tremens (DT)-is a potentially life-threatening condition. While short-term treatment regimens and factors that predispose to more severe symptomatology have been extensively studied, little attention has been paid to the clinical epidemiology and long-term care of the chronic medical, addictive, psychiatric, and psychosocial problems faced by these patients. METHODS: National Veterans Health Administration data from fiscal year 2012 were examined to identify veterans diagnosed with DT; with withdrawal but not DT (WNDT); and with Alcohol Use Disorder (AUD) but neither DT nor WNDT...
August 24, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28835443/a-statewide-evaluation-of-seven-strategies-to-reduce-opioid-overdose-in-north-carolina
#19
Apostolos A Alexandridis, Agnieszka McCort, Christopher L Ringwalt, Nidhi Sachdeva, Catherine Sanford, Stephen W Marshall, Karin Mack, Nabarun Dasgupta
BACKGROUND: In response to increasing opioid overdoses, US prevention efforts have focused on prescriber education and supply, demand and harm reduction strategies. Limited evidence informs which interventions are effective. We evaluated Project Lazarus, a centralised statewide intervention designed to prevent opioid overdose. METHODS: Observational intervention study of seven strategies. 74 of 100 North Carolina counties implemented the intervention. Dichotomous variables were constructed for each strategy by county-month...
August 23, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28833832/pretreatment-ethyl-glucuronide-levels-predict-response-to-a-contingency-management-intervention-for-alcohol-use-disorders-among-adults-with-serious-mental-illness
#20
Michael Gerard McDonell, Emily Leickly, Sterling McPherson, Jordan Skalisky, Katherine Hirchak, Oladunni Oluwoye, Debra Srebnik, John Michael Roll, Richard Kirkland Ries
BACKGROUND AND OBJECTIVES: This study investigated if pretreatment ethyl glucuronide (EtG) levels corresponding to light (100 ng/mL), heavy (500 ng/mL), and very heavy (1,000 ng/mL) drinking predicted longest duration of alcohol abstinence (LDA) and proportion of EtG-negative urine tests in outpatients receiving a 12-week EtG-based contingency management (CM) intervention for alcohol dependence. METHODS: Participants were 40 adults diagnosed with alcohol use disorders and serious mental illness who submitted up to 12 urine samples for EtG analysis during a 4-week observation period and were then randomized to 12-weeks of CM for alcohol abstinence and addiction treatment attendance...
August 18, 2017: American Journal on Addictions
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