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https://www.readbyqxmd.com/read/29140430/the-european-society-for-medical-oncology-esmo-precision-medicine-glossary
#1
L R Yates, J Seoane, C Le Tourneau, L L Siu, R Marais, S Michiels, J C Soria, P Campbell, N Normanno, A Scarpa, J S Reis-Filho, J Rodon, C Swanton, F Andre
Background: Precision medicine is rapidly evolving within the field of oncology and has brought many new concepts and terminologies that are often poorly defined when first introduced, which may subsequently lead to miscommunication within the oncology community. The European Society for Medical Oncology (ESMO) recognises these challenges and is committed to support the adoption of precision medicine in oncology. To add clarity to the language used by oncologists and basic scientists within the context of precision medicine, the ESMO Translational Research and Personalised Medicine Working Group has developed a standardised glossary of relevant terms...
November 13, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29140145/monitoring-rugby-players-for-fitness-and-fatigue-what-do-coaches-want
#2
Lindsay T Starling, Michael I Lambert
PURPOSE: The advantages of monitoring players in a team are well documented. However, barriers associated with lack of resources and time prevents teams from implementing systematic monitoring programs. This study aims to identify 1) the methods rugby teams use to monitor the training load and associated response to the training load, and 2) prerequisites of a monitoring protocol that are scientifically suitable and practically applicable for monitoring fitness and fatigue of rugby players...
November 15, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29138211/transcriptome-sequencing-of-the-naked-mole-rat-heterocephalus-glaber-and-identification-of-hypoxia-tolerance-genes
#3
Bang Xiao, Li Li, Chang Xu, Shanmin Zhao, Lifang Lin, Jishuai Cheng, Wenjing Yang, Wei Cong, Guanghan Kan, Shufang Cui
The naked mole rat (NMR; Heterocephalus glaber) is a small rodent species found in regions of Kenya, Ethiopia and Somalia. It has a high tolerance for hypoxia and is thus, considered one of the most important natural models for studying hypoxia tolerance mechanisms. The various mechanisms underlying the NMR's hypoxia tolerance are beginning to be understood at different levels of organization, and next-generation sequencing methods promise to expand this understanding to the level of gene expression. In this study, we examined the sequence and transcript abundance data of the muscle transcriptome of NMRs exposed to hypoxia using the Illumina HiSeq 2500 system to clarify the possible genomic adaptive responses to the hypoxic underground surroundings...
November 14, 2017: Biology Open
https://www.readbyqxmd.com/read/29138127/exploring-working-relationships-in-mental-health-care-via-an-e-recovery-portal-qualitative-study-on-the-experiences-of-service-users-and-health-providers
#4
Monica Strand, Deede Gammon, Lillian Sofie Eng, Cornelia Ruland
BACKGROUND: The quality of working relationships between service users and health providers is fundamental in the processes of recovery in mental health. How Internet-based interventions will influence these relationships for persons with long-term care needs, and the measures that can be taken to maintain and enhance working relationships through Internet, is still not well understood. OBJECTIVE: The aim of this study was to gain insights into how service users and health providers experience their working relationships when they are offered the option of supplementing ongoing collaboration with an e-recovery portal...
November 14, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/29136774/an-overview-of-neuroprotective-and-cognitive-enhancement-properties-of-lignans-from-schisandra-chinensis
#5
REVIEW
Kandhasamy Sowndhararajan, Ponnuvel Deepa, Minju Kim, Se Jin Park, Songmun Kim
Schisandra chinensis fruits have been traditionally used for thousands of years in Korea, China and Japan to treat various ailments. The fruits contain a variety of bioactive metabolites, especially lignan components have been reported to have various biological activities and have potential in the treatment of numerous neurodegenerative diseases. The lignans from S. chinensis are mainly grouped under dibenzocyclooctadiene lignans. Previous studies have reported that the crude extracts and the isolated pure lignan components effectively protect the neuronal cell damage and significantly enhance the cognitive performances...
November 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29136323/increasing-canopy-photosynthesis-in-rice-can-be-achieved-without-a-large-increase-in-water-use-a-model-based-on-free-air-co2-enrichment
#6
Hiroki Ikawa, Charles P Chen, Martin Sikma, Mayumi Yoshimoto, Hidemitsu Sakai, Takeshi Tokida, Yasuhiro Usui, Hirofumi Nakamura, Keisuke Ono, Atsushi Maruyama, Tsutomu Watanabe, Tsuneo Kuwagata, Toshihiro Hasegawa
Achieving higher canopy photosynthesis rates is one of the keys to increasing future crop production; however, this typically requires additional water inputs because of increased water loss through the stomata. Lowland rice canopies presently consume a large amount of water, and any further increase in water usage may significantly impact local water resources. This situation is further complicated by changing environmental conditions such as rising atmospheric CO2 concentration ([CO2 ]). Here we modeled and compared evapotranspiration of fully developed rice canopies of a high-yielding rice cultivar (Oryza sativa L...
November 14, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29136241/wikipathways-a-multifaceted-pathway-database-bridging-metabolomics-to-other-omics-research
#7
Denise N Slenter, Martina Kutmon, Kristina Hanspers, Anders Riutta, Jacob Windsor, Nuno Nunes, Jonathan Mélius, Elisa Cirillo, Susan L Coort, Daniela Digles, Friederike Ehrhart, Pieter Giesbertz, Marianthi Kalafati, Marvin Martens, Ryan Miller, Kozo Nishida, Linda Rieswijk, Andra Waagmeester, Lars M T Eijssen, Chris T Evelo, Alexander R Pico, Egon L Willighagen
WikiPathways (wikipathways.org) captures the collective knowledge represented in biological pathways. By providing a database in a curated, machine readable way, omics data analysis and visualization is enabled. WikiPathways and other pathway databases are used to analyze experimental data by research groups in many fields. Due to the open and collaborative nature of the WikiPathways platform, our content keeps growing and is getting more accurate, making WikiPathways a reliable and rich pathway database. Previously, however, the focus was primarily on genes and proteins, leaving many metabolites with only limited annotation...
November 10, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29134826/cancer-patients-recommendations-for-nature-based-design-and-engagement-in-oncology-contexts-qualitative-research
#8
Sarah Blaschke, Clare C O'Callaghan, Penelope Schofield
OBJECTIVES: To explore cancer patients' recommendations for nature engagement based on their subjective nature experiences and observations in the cancer setting. The rationale was to gain practical insight for delineating relevant and translatable nature-based care and design opportunities in oncology contexts. BACKGROUND: Innovative cancer care services are needed to respond to growing demand and shifting healthcare needs. Engagement with nature has shown multiple health benefits and presents a promising opportunity for application in healthcare to improve outcomes...
January 1, 2017: HERD
https://www.readbyqxmd.com/read/29134435/plant-phenology-supports-the-multi-emergence-hypothesis-for-ebola-spillover-events
#9
Katharina C Wollenberg Valero, Raphael D Isokpehi, Noah E Douglas, Seenith Sivasundaram, Brianna Johnson, Kiara Wootson, Ayana McGill
Ebola virus disease outbreaks in animals (including humans and great apes) start with sporadic host switches from unknown reservoir species. The factors leading to such spillover events are little explored. Filoviridae viruses have a wide range of natural hosts and are unstable once outside hosts. Spillover events, which involve the physical transfer of viral particles across species, could therefore be directly promoted by conditions of host ecology and environment. In this report, we outline a proof of concept that temporal fluctuations of a set of ecological and environmental variables describing the dynamics of the host ecosystem are able to predict such events of Ebola virus spillover to humans and animals...
November 13, 2017: EcoHealth
https://www.readbyqxmd.com/read/29134149/the-response-of-soil-microbial-communities-to-variation-in-annual-precipitation-depends-on-soil-nutritional-status-in-an-oligotrophic-desert
#10
Cristina Montiel-González, Yunuen Tapia-Torres, Valeria Souza, Felipe García-Oliva
Background: Soil microbial communities (SMC) play a central role in the structure and function of desert ecosystems. However, the high variability of annual precipitation could results in the alteration of SMC and related biological processes depending on soil water potential. The nature of the physiological adjustments made by SMC in order to obtain energy and nutrients remains unclear under different soil resource availabilities in desert ecosystems. In order to examine this dynamic, the present study examined the effects of variation in annual precipitation on physiological adjustments by the SMC across two vegetation-soil systems of different soil organic matter input in an oligotrophic desert ecosystem...
2017: PeerJ
https://www.readbyqxmd.com/read/29134131/medicinally-important-aromatic-plants-with-radioprotective-activity
#11
REVIEW
Ravindra M Samarth, Meenakshi Samarth, Yoshihisa Matsumoto
Aromatic plants are often used as natural medicines because of their remedial and inherent pharmacological properties. Looking into natural resources, particularly products of plant origin, has become an exciting area of research in drug discovery and development. Aromatic plants are mainly exploited for essential oil extraction for applications in industries, for example, in cosmetics, flavoring and fragrance, spices, pesticides, repellents and herbal beverages. Although several medicinal plants have been studied to treat various conventional ailments only a handful studies are available on aromatic plants, especially for radioprotection...
November 2017: Future Science OA
https://www.readbyqxmd.com/read/29129949/the-effects-of-malpractice-non-economic-damage-caps-on-the-supply-of-physician-labor-heterogeneity-by-physician-age-and-risk
#12
Michael F Pesko, Meagan Cea, Jayme Mendelsohn, Tara F Bishop
We explore the impact of malpractice caps on non-economic damages that were enacted between 2003 and 2006 on the supply of physician labor, separately for high-malpractice risk and low-malpractice risk physician specialty types, and separately by young and old physicians. We use physician data from the Area Resource File for 2000-2011 and malpractice policy data from the Database of State Tort Law Reforms. We study the impact of these caps using a reverse natural experiment, comparing physician supply in nine states enacting new caps to physician supply in ten states that had malpractice caps in place throughout the full time period...
June 2017: International Review of Law and Economics
https://www.readbyqxmd.com/read/29129939/indigenous-migration-dynamics-in-the-ecuadorian-amazon-a-longitudinal-and-hierarchical-analysis
#13
Jason Davis, Samuel Sellers, Clark Gray, Richard Bilsborrow
Amazonian indigenous populations are approaching a critical stage in their history in which increasing education and market integration, rapid population growth and degradation of natural resources threaten the survival of their traditions and livelihoods. A topic that has hardly been touched upon in this context is migration and population mobility. We address this by analysing a unique longitudinal dataset from the Ecuadorian Amazon on the spatial mobility of five indigenous groups and mestizo co-residents...
2017: Journal of Development Studies
https://www.readbyqxmd.com/read/29129378/transvaginal-natural-orifice-transluminal-endoscopic-surgery-a%C3%A2-new-approach-to-myomectomy
#14
Jan Baekelandt
OBJECTIVE: To demonstrate a new approach for performing a myomectomy via transvaginal natural-orifice transluminal endoscopic surgery (vNOTES) as an alternative to laparoscopic myomectomy. DESIGN: Stepwise explanation of the technique with the use of original video footage. SETTING: Hospital. PATIENT(S): Eight patients were treated transvaginally for intramural, subserosal, and pedunculated myomas. INTERVENTION(S): In case of a posterior myoma, a 2...
November 9, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29128685/unravelling-positive-aspects-of-caregiving-in-dementia-an-integrative-review-of-research-literature
#15
REVIEW
Doris S F Yu, Sheung-Tak Cheng, Jungfang Wang
BACKGROUND: Family caregiving is the crucial informal care resource to lessen the burdens associated with dementia. Research in this field has focused on reducing the caregiver's burden, but little attention has been given to promoting the positive aspects of caregiving. OBJECTIVES: To conduct a systematic critical review of research on the nature of positive aspects of caregiving, and the factors predicting this phenomenon among family caregivers of dementia patients, with the ultimate purpose of gaining insights to explain how and why it emerges...
October 16, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29128119/sensitivity-of-water-energy-nexus-to-dam-operation-a-water-energy-productivity-concept
#16
Mohammed Basheer, Nadir Ahmed Elagib
Understanding and modelling the complex nature of interlinkages between water and energy are essential for efficient use of the two resources. Hydropower storage dams represent an interesting example of the water-energy interdependencies since they are often multipurpose. The concept of Water-Energy Productivity (WEP), defined as the amount of energy produced per unit of water lost in the process, is introduced in this study to illustrate the relationship between energy generation and water losses by examining the sensitivity of the Water-Energy Nexus (WEN) to changing dam operation policy...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29127790/oil-and-gas-development-footprint-in-the-piceance-basin-western-colorado
#17
Cericia Martinez, Todd M Preston
Understanding long-term implications of energy development on ecosystem function requires establishing regional datasets to quantify past development and determine relationships to predict future development. The Piceance Basin in western Colorado has a history of energy production and development is expected to continue into the foreseeable future due to abundant natural gas resources. To facilitate analyses of regional energy development we digitized all well pads in the Colorado portion of the basin, determined the previous land cover of areas converted to well pads over three time periods (2002-2006, 2007-2011, and 2012-2016), and explored the relationship between number of wells per pad and pad area to model future development...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29126701/the-role-of-digital-health-in-making-progress-toward-sustainable-development-goal-sdg-3-in-conflict-affected-populations
#18
Yara M Asi, Cynthia Williams
PURPOSE: The progress of the Millennium Development Goals (MDGs) shows that sustained global action can achieve success. Despite the unprecedented achievements in health and education, more than one billion people, many of them in conflict-affected areas, were unable to reap the benefits of the MDG gains. The recently developed Sustainable Development Goals (SDGs) are even more ambitious then their predecessor. SDG 3 prioritizes health and well-being for all ages in specific areas such as maternal mortality, communicable diseases, mental health, and healthcare workforce...
November 6, 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29126172/native-honey-bees-outperform-adventive-honey-bees-in-increasing-pyrus-bretschneideri-rosales-rosaceae-pollination
#19
Tolera Kumsa Gemeda, Youquan Shao, Wenqin Wu, Huipeng Yang, Jiaxing Huang, Jie Wu
The foraging behavior of different bee species is a key factor influencing the pollination efficiency of different crops. Most pear species exhibit full self-incompatibility and thus depend entirely on cross-pollination. However, as little is known about the pear visitation preferences of native Apis cerana (Fabricius; Hymenoptera: Apidae) and adventive Apis mellifera (L.; Hymenoptera: Apidae) in China. A comparative analysis was performed to explore the pear-foraging differences of these species under the natural conditions of pear growing areas...
November 6, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29126053/a-new-method-and-a-new-index-for-identifying-socioeconomic-drought-events-under-climate-change-a-case-study-of-the-east-river-basin-in-china
#20
Haiyun Shi, Ji Chen, Keyi Wang, Jun Niu
Drought is a complex natural hazard that may have destructive damages on societal properties and even lives. Generally, socioeconomic drought occurs when water resources systems cannot meet water demand, mainly due to a weather-related shortfall in water supply. This study aims to propose a new method, a heuristic method, and a new index, the socioeconomic drought index (SEDI), for identifying and evaluating socioeconomic drought events on different severity levels (i.e., slight, moderate, severe, and extreme) in the context of climate change...
November 7, 2017: Science of the Total Environment
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