Read by QxMD icon Read

RSV bronchiolitis

Wenkuan Liu, Dehui Chen, Weiping Tan, Duo Xu, Shuyan Qiu, Zhiqi Zeng, Xiao Li, Rong Zhou
Respiratory syncytial virus (RSV) is one of the most important pathogenic infections of children and requires in-depth research worldwide, and especially in developing countries. We used a novel multiplex real-time PCR to test 5483 patients (≤ 14 years old) hospitalized with respiratory illness in Guangzhou, China, over a 3-year period. Of these patients, 729 were positive for RSV-A (51.2%, 373/729) or RSV-B (48.8%, 356/729), but none was infected with both viruses. Two seasonal peaks in total RSV were detected at the changes from winter to spring and from summer to autumn...
2016: PloS One
Ah Young Kim, Se Yong Jung, Jae Young Choi, Gi Beom Kim, Young-Hwue Kim, Woo Sup Shim, I-Seok Kang, Jo Won Jung
BACKGROUND AND OBJECTIVES: We conducted a review of current data on respiratory syncytial virus (RSV) prophylaxis with palivizumab, in Korean children with congenital heart diseases (CHD). In 2009, the Korean guideline for RSV prophylaxis had established up to five shots monthly per RSV season, only for children <1 year of age with hemodynamic significance CHD (HS-CHD). SUBJECTS AND METHODS: During the RSV seasons in 2009-2015, we performed a retrospective review of data for 466 infants with CHD, examined at six centers in Korea...
September 2016: Korean Circulation Journal
Julia Reis, Jeffrey Shaman
Recent studies have shown that systems combining mathematical modeling and Bayesian inference methods can be used to generate real-time forecasts of future infectious disease incidence. Here we develop such a system to study and forecast respiratory syncytial virus (RSV). RSV is the most common cause of acute lower respiratory infection and bronchiolitis. Advanced warning of the epidemic timing and volume of RSV patient surges has the potential to reduce well-documented delays of treatment in emergency departments...
October 2016: PLoS Computational Biology
Ana Calderón, Francisco Pozo, Cristina Calvo, Mluz García-García, Mónica González-Esguevillas, Mar Molinero, Inmaculada Casas
Human respiratory syncytial virus group A (RSV-A) was detected in symptomatic hospital attended children in Central Spain for a continuous time period, September 2010 to April 2015. In order to accurately describe the epidemiology of this virus, the genetic diversity of the complete G gene and the clinical manifestations observed were jointly analyzed. Out of 3,011 respiratory specimens taken from 2,308 children, 640 were positive to RSV (21.3%) and 405 were RSV-A (63.2%). Complete G gene sequences of 166 randomly selected RSV-A virus identified NA1 and ON1 genotypes...
October 3, 2016: Journal of Medical Virology
Joanne M Langley, Naresh Aggarwal, Azhar Toma, Scott A Halperin, Shelly A McNeil, Laurence Fissette, Walthere Dewé, Maarten Leyssen, Jean-François Toussaint, Ilse Dieussaert
BACKGROUND:  RSV is a leading cause of childhood bronchiolitis and pneumonia, particularly in early infancy. Immunization of pregnant women could boost pre-existing immune responses, providing passive protection to the newborn through placental transfer of anti-RSV antibody. METHODS:  In this first-in-humans clinical trial of a purified recombinant RSV protein F vaccine engineered to preferentially maintain pre-fusion conformation (RSV-PreF), 128 healthy men 18-44 years old were randomized to one dose of a RSV-PreF vaccine containing 10, 30 or 60 µg of RSV-PreF antigen with or without alum adjuvant, or control, and followed for one year for safety and immunogenicity outcomes...
September 29, 2016: Journal of Infectious Diseases
Xiao-Li Yan, Yu-Ning Li, Yi-Jie Tang, Zhi-Ping Xie, Han-Chun Gao, Xue-Mei Yang, Yu-Mei Li, Li-Jun Liu, Zhao-Jun Duan
Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are two common viral pathogens in acute lower respiratory tract infections (ALRTI). However, the association of viral load with clinical characteristics is not well-defined in ALRTI. To explore the correlation between viral load and clinical characteristics of RSV and HMPV in children hospitalized for ALRTI in Lanzhou, China. 387 children hospitalized for ALRTI were enrolled. Nasopharyngeal aspirates (NPAs) were sampled from each children. Real-time PCR was used to screen RSV, HMPV and twelve additional respiratory viruses...
September 15, 2016: Journal of Medical Virology
Bo Liang, Joan O Ngwuta, Richard Herbert, Joanna Swerczek, David W Dorward, Emerito Amaro-Carambot, Natalie Mackow, Barbora Kabatova, Matthias Lingemann, Sonja Surman, Lijuan Yang, Man Chen, Syed M Moin, Azad Kumar, Jason S McLellan, Peter D Kwong, Barney S Graham, Anne Schaap-Nutt, Peter L Collins, Shirin Munir
: Human respiratory syncytial virus (RSV) and human parainfluenza virus type 3 (HPIV3) are major pediatric respiratory pathogens that lack vaccines. A chimeric bovine/human PIV3 (rB/HPIV3) virus expressing the unmodified, wild-type (wt) RSV fusion (F) protein from an added gene was previously evaluated in seronegative children as a bivalent intranasal RSV/HPIV3 vaccine, and it was well tolerated but insufficiently immunogenic for RSV F. We recently showed that rB/HPIV3 expressing a partially stabilized prefusion form (pre-F) of RSV F efficiently induced "high-quality" RSV-neutralizing antibodies, defined as antibodies that neutralize RSV in vitro without added complement (B...
November 1, 2016: Journal of Virology
Giacomo Pongiglione, Alessandro Possidoni, Umberto di Luzio Paparatti, Anna Maria Costanzo, Giuliana Gualberti, Marco Bonvicini, Alessandro Rimini, Gabriella Agnoletti, Maria Pia Calabrò, Marco Pozzi, Roberto Tumbarello, Patrizia Salice, Patrizio Fiorini, Maria Giovanna Russo, Ornella Milanesi
Children affected by hemodynamically significant congenital heart disease (HSCHD) experience severe respiratory complications that can increase the frequency of hospitalizations. The aim of the SINERGY study was to describe the incidence of respiratory diseases and to collect information on active and passive immunoprophylaxis in the first 2 years of life. In this retrospective, multicenter, and epidemiologic study, children with HSCHD were enrolled across 11 Italian sites. Children born between December 31, 2007, and December 31, 2012, were observed during their first 2 years of life...
August 29, 2016: Pediatric Cardiology
Martijn J Schuijs, Susanne Hartmann, Murray E Selkirk, Luke B Roberts, Peter J M Openshaw, Corinna Schnoeller
Respiratory Syncytial Virus (RSV) is a major pathogen causing low respiratory tract disease (bronchiolitis), primarily in infants. Helminthic infections may alter host immune responses to both helminths and to unrelated immune triggers. For example, we have previously shown that filarial cystatin (AvCystatin/Av17) ameliorates allergic airway inflammation. However, helminthic immunomodulators have so far not been tested in virus-induced disease. We now report that AvCystatin prevents Th2-based immunopathology in vaccine-enhanced RSV lung inflammation, a murine model for bronchiolitis...
2016: PloS One
Seong H Cho, Jin-Young Min, Dong Young Kim, Sam S Oh, Dara R Torgerson, Maria Pino-Yanes, Donglei Hu, Saunak Sen, Scott Huntsman, Celeste Eng, Harold J Farber, William Rodriguez-Cintron, Jose R Rodriguez-Santana, Denise Serebrisky, Shannon M Thyne, Luisa N Borrell, L Keoki Williams, William DuPont, Max A Seibold, Esteban G Burchard, Pedro C Avila, Rajesh Kumar
BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) is induced in airways by virus and may mediate asthmatic airway remodeling. We sought to evaluate if genetic variants and early life lower respiratory infections jointly affect asthma risk. METHODS: We included Latino children, adolescents, and young adults aged 8-21 years (1736 subjects with physician-diagnosed asthma and 1747 healthy controls) from five U.S. centers and Puerto Rico after excluding subjects with incomplete clinical or genetic data...
2016: PloS One
Monica High, Hye-Youn Cho, Jacqui Marzec, Tim Wiltshire, Kirsten C Verhein, Mauricio T Caballero, Patricio L Acosta, Jonathan Ciencewicki, Zackary R McCaw, Lester Kobzik, Laura Miller-DeGraff, Wes Gladwell, David B Peden, M Elina Serra, Min Shi, Clarice Weinberg, Oscar Suzuki, Xuting Wang, Douglas A Bell, Fernando P Polack, Steven R Kleeberger
BACKGROUND: Respiratory syncytial virus (RSV) is the global leading cause of lower respiratory tract infection in infants. Nearly 30% of all infected infants develop severe disease including bronchiolitis, but susceptibility mechanisms remain unclear. METHODS: We infected a panel of 30 inbred strains of mice with RSV and measured changes in lung disease parameters 1 and 5days post-infection and they were used in genome-wide association (GWA) studies to identify quantitative trait loci (QTL) and susceptibility gene candidates...
September 2016: EBioMedicine
Pierre-Louis Hervé, Charlotte Deloizy, Delphyne Descamps, Marie-Anne Rameix-Welti, Jenna Fix, Jason S McLellan, Jean-François Eléouët, Sabine Riffault
Respiratory syncytial virus (RSV) is the leading cause of acute respiratory infections in children, yet no vaccine is available. The sole licensed preventive treatment against RSV is composed of a monoclonal neutralizing antibody (palivizumab), which targets a conformational epitope located on the fusion protein (F). Palivizumab reduces the burden of bronchiolitis but does not prevent infection. Thus, the development of RSV vaccines remains a priority. We previously evaluated nanorings formed by RSV nucleoprotein (N) as an RSV vaccine, as well as an immunostimulatory carrier for heterologous antigens...
August 20, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
Daria B Napierkowski
Respiratory syncytial virus (RSV) is one of the major causes of respiratory tract illness in children and can lead to significant infection and death. This article discusses the incidence, clinical presentation, diagnosis, current treatment, and prevention options to successfully diagnose and treat infections caused by RSV.
September 22, 2016: Nurse Practitioner
Darryl J Adamko, Erik Saude, Matthew Bear, Shana Regush, Joan L Robinson
BACKGROUND: Clinicians lack objective tests to help determine the severity of bronchiolitis or to distinguish a viral from bacterial causes of respiratory distress. We hypothesized that children with respiratory syncytial virus (RSV) infection would have a different metabolomic profile compared to those with bacterial infection or healthy controls, and this might also vary with bronchiolitis severity. METHODS: Clinical information and urine-based metabolomic data were collected from healthy age-matched children (n = 37) and those admitted to hospital with a proven infection (RSV n = 55; Non-RSV viral n = 16; bacterial n = 24)...
August 22, 2016: BMC Infectious Diseases
Aoife Kerrin, Paul Fitch, Claire Errington, Dennis Kerr, Liz Waxman, Kay Riding, Jon McCormack, Felicity Mehendele, Henry McSorley, Karen MacKenzie, Sabine Wronski, Armin Braun, Richard Levin, Ulf Theilen, Jürgen Schwarze
RATIONALE: The pathogenesis of respiratory syncytial virus (RSV) bronchiolitis in infants remains poorly understood. Mouse models implicate pulmonary T cells in the development of RSV disease. T cell responses are initiated by dendritic cells (DCs), which accumulate in lungs of RSV-infected mice. In infants with RSV bronchiolitis, previous reports have shown that DCs are mobilised to the nasal mucosa, but data on lower airway DC responses are lacking. OBJECTIVE: To determine the presence and phenotype of DCs and associated immune cells in bronchoalveolar lavage (BAL) and peripheral blood samples from infants with RSV bronchiolitis...
August 16, 2016: Thorax
Roopa Bhandary, Rekha Boloor
INTRODUCTION: Severe Respiratory Syncytial Virus (RSV) pulmonary disease manifesting as bronchiolitis and pneumonia continues to play a major role in the childhood mortality and morbidity. Hence the present study was undertaken to evaluate the prevalence of RSV among hospitalized children presenting with Acute Respiratory Tract Infection (ARTI) and its correlation with risk factors. AIM: To determine the occurrence of RSV related respiratory tract infection in paediatric patients and to access the risk factors and clinical features associated...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
Allison F Christiaansen, Muhammad A Syed, Patrick P Ten Eyck, Stacey M Hartwig, Lakshmi Durairaj, Sameer S Kamath, Steven M Varga
BACKGROUND: Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and pneumonia in children under 1 y of age in the USA. The host immune response is believed to contribute to RSV-induced disease. We hypothesize that severe RSV infection in infants is mediated by insufficient regulation of the host immune response of regulatory T cells (Tregs) resulting in immunopathology. METHODS: Blood and nasal aspirates from 23 RSV-infected and 17 control infants under 1 y of age were collected...
August 3, 2016: Pediatric Research
Leon Caly, Hong-Mei Li, David Jans
Although respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and pneumonia in infants and the elderly worldwide [1], the protein-protein interactions between the host cell and virus remain poorly understood. We have used a focused small interfering RNA (siRNA) approach to knock-down and examine the role(s) of various host cell proteins. Here, we describe approaches for casein kinase 2α (CK2α) as a key example. We show how to study the effect of host gene (CK2α) knockdown using siRNA on cell-associated and released virus titers, using both quantitative RT-PCR, which measures the level of viral RNA, and plaque assay, which measures infectious virus directly...
2016: Methods in Molecular Biology
Harold J Farber, Frederick J Buckwold, Barry Lachman, J Scott Simpson, Ernest Buck, Matha Arun, Adolfo M Valadez, Teresa Ruiz, Joy Alonzo, Andrea Henry, Nneka Cos-Okpalla, Kelsey Nguyen, William Brendel, James Small, William Brendle Glomb
BACKGROUND: Respiratory syncytial virus (RSV) is a common reason for hospitalization of infants. In clinical trials, palivizumab reduced RSV hospitalization rates for premature infants. The 2014 American Academy of Pediatrics clinical practice guideline advised against use of palivizumab for otherwise healthy infants ≥29 weeks' gestation. The aim of this study was to determine the effect of palivizumab administration on hospitalization rates for RSV and bronchiolitis without RSV diagnosis among infants 29 to 36 weeks' gestation who do not have chronic illness...
August 2016: Pediatrics
Pratima Shrivastava, Indranil Sarkar, Ethel Atanley, Susantha Gomis, Sylvia van Drunen Littel-van den Hurk
Respiratory syncytial virus (RSV) is a major cause of bronchiolitis and pneumonia in infants and pneumonia virus of mice (PVM) causes similar disease. BALB/c mice are highly susceptible, while C57BL/6 mice are more resistant to PVM. IL-12 was significantly more up-regulated in response to PVM infection in BALB/c than in C57BL/6 mice. IL-12p40-deficient neonatal and adult BALB/c mice showed significantly less weight loss than wild-type mice after PVM challenge. The percentage of regulatory T cells, as well as IFN-β and IL-18 expression, was higher in the lungs of both neonatal and adult IL-12p40-/- mice...
October 2016: Virology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"