keyword
MENU ▼
Read by QxMD icon Read
search

Severe malaria anemia

keyword
https://www.readbyqxmd.com/read/28542307/the-mouse-char10-locus-regulates-severity-of-pyruvate-kinase-deficiency-and-susceptibility-to-malaria
#1
Aurélie Laroque, Gundula Min-Oo, Mifong Tam, Prem Ponka, Mary M Stevenson, Philippe Gros
Pyruvate kinase (PKLR) deficiency protects mice and humans against blood-stage malaria. Although mouse strain AcB62 carries a malaria-protective PklrI90N genetic mutation, it is phenotypically susceptible to blood stage malaria induced by infection with Plasmodium chabaudi AS, suggesting a genetic modifier of the PklrI90N protective effect. Linkage analysis in a F2 cross between AcB62 (PklrI90N) and another PK deficient strain CBA/Pk (PklrG338D) maps this modifier (designated Char10) to chromosome 9 (LOD = 10...
2017: PloS One
https://www.readbyqxmd.com/read/28531196/co-inheritance-of-glucose-6-phosphate-dehydrogenase-deficiency-mutations-and-hemoglobin-e-in-a-kachin-population-in-a-malaria-endemic-region-of-southeast-asia
#2
Zeshuai Deng, Fang Yang, Yao Bai, Lijun He, Qing Li, Yanrui Wu, Lan Luo, Hong Li, Limei Ma, Zhaoqing Yang, Yongshu He, Liwang Cui
Glucose-6-phosphate dehydrogenase (G6PD) deficiency and hemoglobin E (HbE, β26 Glu-Lys) are two common red cell disorders in Southeast Asia. G6PD deficiency produces hemolytic anemia, which can be triggered by certain drugs or infections. HbE is asymptomatic or is manifested as microcytic, minimally hemolytic anemia. The association between G6PD deficiency and HbE is little understood. This study aimed to investigate G6PD deficiency and HbE in a Kachin ethnic group in the China-Myanmar border area. G6PD enzyme activity was measured using a quantitative G6PD assay, G6PD variants genotyped by the SNaPshot assay, and an HbE gene mutation identified by an amplification refractory mutation system and subsequently confirmed by using a reverse dot blot hybridization assay from 100 unrelated individuals in the study area...
2017: PloS One
https://www.readbyqxmd.com/read/28524208/microfluidic-analysis-of-red-blood-cell-deformability-as-a-means-to-assess-hemin-induced-oxidative-stress-resulting-from-plasmodium-falciparum-intraerythrocytic-parasitism
#3
Kerryn Matthews, Simon P Duffy, Marie-Eve Myrand-Lapierre, Richard R Ang, Li Li, Mark D Scott, Hongshen Ma
Hemolytic anemia is one of the hallmarks of malaria and leads to an increase in oxidized heme (hemin) within the plasma of infected individuals. While scavenger proteins sequester much of the circulating heme, it has been hypothesized that extracellular heme may play a central role in malaria pathogenesis. We have previously developed the multiplex fluidic plunger (MFP) device for the measurement of red blood cell (RBC) deformability. Here, we demonstrate that the measurement of changes in RBC deformability is a sensitive method for inferring heme-induced oxidative stress...
May 19, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28513513/electrocardiographic-changes-and-troponin-t-levels-in-children-with-severe-malaria-anemia-and-heart-failure
#4
W E Sadoh, J O Uduebor
BACKGROUND: Severe malaria anemia is a major cause of childhood heart failure in malaria endemic countries. The resulting hypoxic-ischemic injuries may cause myocardial damage detectable by electrocardiogram (ECG) and elevated troponin T (cTnT) levels. OBJECTIVE: Evaluate the ECG changes and cTnT levels in children with severe malaria anemia compared with those who had uncomplicated malaria without anemia. METHODS: Consecutive children with severe malaria anemia were recruited as subjects while controls were age- and gender-matched children with uncomplicated malaria without anemia...
May 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28502227/malaria-and-severe-anemia-over-eight-years-at-gambo-rural-hospital-southern-ethiopia
#5
Pablo Barreiro, Gebre Tiziano, Haji Fano, Tafesse Yohannes, Ashenafi Gosa, Francisco Reyes, Abraham Tesfamariam, Miguel Górgolas, José M Ramos
Evolution of incident malaria and frequency of anemia were analyzed over eight years in a rural hospital in southern Ethiopia. Capillary blood samples were tested for hemoglobin concentration, and in some instances for malaria parasites, at Gambo Rural General Hospital between January 2007 and September 2014, and the results recorded. Main demographic data were also recorded in subjects with Plasmodium sp. infections. Of a total of 54,493 blood samples taken from 45,096 different patients, 21,723 (39.9%) samples from 19,173 (42...
May 13, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28500775/vaccines-against-malaria-still-a-long-way-to-go
#6
REVIEW
Kai Matuschewski
Several species of Plasmodium cause a broad spectrum of human disease that range from nausea and fever to severe anemia, cerebral malaria, and multi-organ failure. In malaria-endemic countries continuous exposure to Plasmodium sporozoite inoculations and subsequent blood infections elicit only partial and short-lived immunity, which gradually develops over many years of parasite exposure and multiple clinical episodes. The ambitious goal of malaria vaccinology over the past 70 years has been to develop an immunization strategy that mounts protection superior to naturally acquired immunity...
May 13, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28467452/prevalence-of-anemia-and-associated-factors-in-children-living-in-urban-and-rural-settings-from-bata-district-equatorial-guinea-2013
#7
Policarpo Ncogo, Maria Romay-Barja, Agustin Benito, Pilar Aparicio, Gloria Nseng, Pedro Berzosa, Maria A Santana-Morales, Matilde Riloha, Basilio Valladares, Zaida Herrador
Anemia in children under 5 years of age is a global public health problem. According to the World Health Organization the current rate of anemia among preschool aged children in Equatorial Guinea is 66%. No information is available above this age. The cross-sectional Prevamal Survey was conducted in 2013 aimed at providing baseline data on malaria prevalence in children aged 2 months-15 years old. Sampling was carried out with the use of a multistage, stratified cluster strategy in the district of Bata, Equatorial Guinea...
2017: PloS One
https://www.readbyqxmd.com/read/28445440/micronutrient-status-among-pregnant-women-in-zinder-niger-and-risk-factors-associated-with-deficiency
#8
K Ryan Wessells, Césaire T Ouédraogo, Rebecca R Young, M Thierno Faye, Alex Brito, Sonja Y Hess
Anemia and micronutrient (MN) deficiencies in pregnant women are associated with adverse pregnancy outcomes. In Niger, 58.6% of pregnant women are anemic; however, MN statuses are unknown. The study objectives were to estimate the prevalence of MN deficiencies among pregnant women in Zinder, Niger and explore associated risk factors. Pregnant women living in randomly selected rural villages (n = 88) were included. Capillary and venous blood samples (n = 770) were analyzed for hemoglobin (Hb) and plasma ferritin, soluble transferrin receptor (sTfR), zinc (pZn), retinol binding protein (RBP), folate and vitamin B12...
April 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28427365/association-between-fc%C3%AE-receptor-iia-iiia-and-iiib-genetic-polymorphisms-and-susceptibility-to-severe-malaria-anemia-in-children-in-western-kenya
#9
Elly O Munde, Winnie A Okeyo, Evans Raballah, Samuel B Anyona, Tom Were, John M Ong'echa, Douglas J Perkins, Collins Ouma
BACKGROUND: Naturally-acquired immunity to Plasmodium falciparum malaria develops after several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG) antibodies and mediate phagocytosis of opsonized microbes, thereby, linking humoral and cellular immunity. FcγR polymorphisms influence binding affinity to IgGs and consequently, can influence clinical malaria outcomes. Specifically, variations in FcγRIIA -131Arg/His, FcγRIIIA-176F/V and FcγRIIIB-NA1/NA2 modulate immune responses through altered binding preferences to IgGs and immune complexes...
April 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28427357/haplotype-of-non-synonymous-mutations-within-il-23r-is-associated-with-susceptibility-to-severe-malaria-anemia-in-a-p-falciparum-holoendemic-transmission-area-of-kenya
#10
Elly O Munde, Evans Raballah, Winnie A Okeyo, John M Ong'echa, Douglas J Perkins, Collins Ouma
BACKGROUND: Improved understanding of the molecular mechanisms involved in pediatric severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel therapeutics. Identification of host genetic susceptibility factors in immune regulatory genes offers an important tool for deciphering malaria pathogenesis. The IL-23/IL-17 immune pathway is important for both immunity and erythropoiesis via its effects through IL-23 receptors (IL-23R). However, the impact of IL-23R variants on SMA has not been fully elucidated...
April 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28426727/cd4-t-cell-expression-of-ifn-%C3%AE-and-il-17-in-pediatric-malarial-anemia
#11
Evans Raballah, Prakasha Kempaiah, Zachary Karim, George O Orinda, Michael F Otieno, Douglas J Perkins, John Michael Ong'echa
In Plasmodium falciparum holoendemic transmission regions of western Kenya, life-threatening pediatric malaria manifests primarily as severe malarial anemia (SMA, Hb≤6.0 g/dL with any density parasitemia). To determine the role that CD4+ T-cell-driven inflammatory responses have in the pathogenesis of SMA, peripheral CD4+ T-cell populations and their intracellular production of pro-inflammatory cytokines (IFN-γ and IL-17) were characterized in children aged 12-36 months of age stratified into two groups: non-severe malarial anemia (non-SMA, Hb≥6...
2017: PloS One
https://www.readbyqxmd.com/read/28362936/high-frequency-of-blackwater-fever-among-children-presenting-to-hospital-with-severe-febrile-illnesses-in-eastern-uganda
#12
Peter Olupot-Olupot, Charles Engoru, Sophie Uyoga, Rita Muhindo, Alex Macharia, Sarah Kiguli, Robert O Opoka, Samuel Akech, Carolyne Ndila, Richard Nyeko, George Mtove, Julius Nteziyaremye, Martin Chebet, Elizabeth C George, Abdel G Babiker, Diana M Gibb, Thomas N Williams, Kathryn Maitland
Background: In the Fluid Expansion as a Supportive Treatment (FEAST) trial, an unexpectedly high proportion of participants from eastern Uganda presented with blackwater fever (BWF). Methods: We describe the prevalence and outcome of BWF among trial participants and compare the prevalence of 3 malaria-protective red blood cell polymorphisms in BWF cases vs both trial (non-BWF) and population controls. Results: Of 3170 trial participants, 394 (12...
April 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28339598/high-postdischarge-morbidity-in-ugandan-children-with-severe-malarial-anemia-or-cerebral-malaria
#13
Robert O Opoka, Karen E S Hamre, Nathan Brand, Paul Bangirana, Richard Idro, Chandy C John
Summary: Postdischarge readmission and outpatient illnesses are frequent in children with severe malarial anemia or cerebral malaria. Trials of postdischarge malaria prophylaxis in children with severe malaria should be considered. Background: Cerebral malaria (CM) and severe malarial anemia (SMA) account for a substantial proportion of malaria-related deaths in sub-Saharan Africa. However, postdischarge morbidity in children with CM or SMA has not been well established...
October 7, 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28337387/pro-and-anti-inflammatory-cytokines-in-children-with-malaria-in-franceville-gabon
#14
Sandrine Lydie Oyegue-Liabagui, Aline Gaëlle Bouopda-Tuedom, Lady Charlène Kouna, Sydney Maghendji-Nzondo, Herman Nzoughe, Nina Tchitoula-Makaya, Irene Pegha-Moukandja, Jean-Bernard Lekana-Douki
Severe Plasmodium falciparum malaria anemia (SMA) is a major cause of mortality in pediatric wards. Variations in inflammatory mediator production play an essential role in disease outcomes. Indeed, several studies have shown the involvement of pro- and anti-inflammatory cytokines such as IFN-γ, IL-6, TNF-α and IL-10 in malaria immunopathology. In other hand the exact role of Th17 cytokines such as IL-17, IL-22 and IL-21 in malaria remains poorly documented. Here, we investigated IFN-γ, TNF-α, IL-6, IL-12, IL-10, IL-4, IL-13, IL-17, IL-22 and IL-21 circulating levels and their association with malaria anemia and parasitemia in Gabonese children...
2017: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28298924/hematological-parameters-and-hemozoin-containing-leukocytes-and-their-association-with-disease-severity-among-malaria-infected-children-a-cross-sectional-study-at-pawe-general-hospital-northwest-ethiopia
#15
Muluken Birhanu, Yaregal Asres, Wondimagegn Adissu, Tilahun Yemane, Endalew Zemene, Lealem Gedefaw
Hematological parameter changes are the most common complications in malaria. We aimed to determine the hematological parameters and hemozoin-containing leukocytes and their association with disease severity in malaria infected children aged between 1 and 15 years. A facility-based cross-sectional study was conducted at Pawe General Hospital from July 31 to December 30, 2014. Demographic and clinical data were collected using structured questionnaire. Blood specimen was collected from each study participant for hematological investigations...
2017: Interdisciplinary Perspectives on Infectious Diseases
https://www.readbyqxmd.com/read/28274886/increased-susceptibility-of-blood-type-o-individuals-to-develop-anemia-in-plasmodium-vivax-infection
#16
Sarah Stela Resende, Vanessa Gonçalves Milagres, Daniel Gonçalves Chaves, Cor Jesus Fernandes Fontes, Luzia Helena Carvalho, Tais Nobrega Sousa, Cristiana Ferreira Alves de Brito
Plasmodium vivax has been reported to cause severe malaria, and one of the main resulting complications is anemia. Considering that P. vivax infects only young erythrocytes, anemia has been associated with the destruction of infected and non-infected erythrocytes. However, few studies have focused on understanding the relationship between the pathogenesis of P. vivax malaria and human genetic polymorphisms. Although ABO groups seem to influence the outcome of Plasmodium falciparum malaria, the association between P...
March 6, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28193740/development-of-delayed-hemolytic-anemia-after-treatment-with-oral-artemether-lumefantrine-in-two-patients-with-severe-falciparum-malaria
#17
Yasuhiro Tsuchido, Fukumi Nakamura-Uchiyama, Kasumi Toyoda, Moritoshi Iwagami, Kentaro Tochitani, Koh Shinohara, Naokuni Hishiya, Taku Ogawa, Kenji Uno, Kei Kasahara, Yukiteru Ouji, Shigeyuki Kano, Keiichi Mikasa, Tsunehiro Shimizu, Masahide Yoshikawa, Haruhiko Maruyama
AbstractRecently, reports of delayed hemolytic anemia after treatment with artemisinin and its derivatives have emerged. Here we report two cases of delayed hemolytic anemia in a patient with severe falciparum malaria after treatment with oral artemether-lumefantrine (AL). The first patient, a 20-year-old Japanese male student, was diagnosed with falciparum malaria and was administered AL. As having a high parasitemia rate (20.6%) was the only severe malaria criterion met in this case and his general condition was stable, we continued with AL treatment...
May 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28155887/signatures-of-malaria-associated-pathology-revealed-by-high-resolution-whole-blood-transcriptomics-in-a-rodent-model-of-malaria
#18
Jing-Wen Lin, Jan Sodenkamp, Deirdre Cunningham, Katrien Deroost, Tshibuayi Christine Tshitenge, Sarah McLaughlin, Tracey J Lamb, Bradley Spencer-Dene, Caroline Hosking, Jai Ramesar, Chris J Janse, Christine Graham, Anne O'Garra, Jean Langhorne
The influence of parasite genetic factors on immune responses and development of severe pathology of malaria is largely unknown. In this study, we performed genome-wide transcriptomic profiling of mouse whole blood during blood-stage infections of two strains of the rodent malaria parasite Plasmodium chabaudi that differ in virulence. We identified several transcriptomic signatures associated with the virulent infection, including signatures for platelet aggregation, stronger and prolonged anemia and lung inflammation...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28122790/cytokine-profiles-in-malawian-children-presenting-with-uncomplicated-malaria-severe-malarial-anemia-and-cerebral-malaria
#19
Wilson L Mandala, Chisomo L Msefula, Esther N Gondwe, Mark T Drayson, Malcolm E Molyneux, Calman A MacLennan
Proinflammatory cytokines are involved in clearance of Plasmodium falciparum, and very high levels of these cytokines have been implicated in the pathogenesis of severe malaria. In order to determine how cytokines vary with disease severity and syndrome, we enrolled Malawian children presenting with cerebral malaria (CM), severe malarial anemia (SMA), and uncomplicated malaria (UCM) and healthy controls. We analyzed serum cytokine concentrations in acute infection and in convalescence. With the exception of interleukin 5 (IL-5), cytokine concentrations were highest in acute CM, followed by SMA, and were only mildly elevated in UCM...
April 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28034892/how-i-treat-anemia-in-pregnancy-iron-cobalamin-and-folate
#20
REVIEW
Maureen M Achebe, Anat Gafter-Gvili
Anemia of pregnancy, an important risk factor for fetal and maternal morbidity, is considered a global health problem, affecting almost 50% of pregnant women. In this article, diagnosis and management of iron, cobalamin, and folate deficiencies, the most frequent causes of anemia in pregnancy, are discussed. Three clinical cases are considered. Iron deficiency is the most common cause. Laboratory tests defining iron deficiency, the recognition of developmental delays and cognitive abnormalities in iron-deficient neonates, and literature addressing the efficacy and safety of IV iron in pregnancy are reviewed...
February 23, 2017: Blood
keyword
keyword
63879
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"