keyword
MENU ▼
Read by QxMD icon Read
search

randomized, double-blind, trial

keyword
https://www.readbyqxmd.com/read/28431278/intranasal-oxytocin-does-not-modulate-jumping-to-conclusions-in-schizophrenia-potential-interactions-with-caudate-volume-and-baseline-social-functioning
#1
Fernando Caravaggio, Philip Gerretsen, Wanna Mar, Jun Ku Chung, Eric Plitman, Shinichiro Nakajima, Julia Kim, Yusuke Iwata, Raihaan Patel, M Mallar Chakravarty, Gary Remington, Ariel Graff-Guerrero, Mahesh Menon
BACKGROUND: Patients with schizophrenia (SCZ) tend to sample less information when making a decision, jumping to conclusions (JTC) without sufficient evidence. This "JTC bias" may be a trait marker of the disease and may not improve with antipsychotic treatment. We conducted a double-blind, placebo-controlled trial to test whether intranasal oxytocin could reduce JTC in stable, medicated patients with SCZ and healthy controls (HCs). We also explored whether striatal volume, clinical symptoms, and baseline social functioning (SF) was related to JTC performance...
March 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28431010/clinical-trial-of-the-anti-pd-l1-antibody-bms-936559-in-hiv-1-infected-participants-on-suppressive-antiretroviral-therapy
#2
Cynthia L Gay, Ronald J Bosch, Justin Ritz, Jason M Hataye, Evgenia Aga, Randall L Tressler, Stephen W Mason, Carey K Hwang, Dennis M Grasela, Neelanjana Ray, Josh C Cyktor, John M Coffin, Edward P Acosta, Richard A Koup, John W Mellors, Joseph J Eron
Background.: Reversing immune exhaustion with an anti-PD-L1 antibody may improve HIV-1-specific immunity and increase clearance of HIV-1 expressing cells. Methods.: Phase I, randomized, double-blind, placebo-controlled dose-escalating study of BMS-936559including HIV-1-infected adults ≥18 to ≤70 years on suppressive antiretroviral therapy with CD4+ counts ≥350 cells/μL and detectable plasma HIV-1 RNA by single copy assay. Data on single infusions of BMS-936559 (0...
April 18, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28431003/intracoronary-autologous-bone-marrow-cell-transfer-after-myocardial-infarction-the-boost-2-randomised-placebo-controlled-clinical-trial
#3
Kai C Wollert, Gerd P Meyer, Jochen Müller-Ehmsen, Carsten Tschöpe, Vernon Bonarjee, Alf Inge Larsen, Andreas E May, Klaus Empen, Emmanuel Chorianopoulos, Ulrich Tebbe, Johannes Waltenberger, Heiko Mahrholdt, Benedikta Ritter, Jens Pirr, Dieter Fischer, Mortimer Korf-Klingebiel, Lubomir Arseniev, Hans-Gert Heuft, Jan E Brinchmann, Diethelm Messinger, Bernd Hertenstein, Arnold Ganser, Hugo A Katus, Stephan B Felix, Meinrad P Gawaz, Kenneth Dickstein, Heinz-Peter Schultheiss, Dennis Ladage, Simon Greulich, Johann Bauersachs
Aims: Intracoronary infusion of autologous nucleated bone marrow cells (BMCs) enhanced the recovery of left ventricular ejection fraction (LVEF) after ST-segment elevation myocardial infarction (STEMI) in the randomised-controlled, open-label BOOST trial. We reassessed the therapeutic potential of nucleated BMCs in the randomised placebo-controlled, double-blind BOOST-2 trial conducted in 10 centres in Germany and Norway. Methods and results: Using a multiple arm design, we investigated the dose-response relationship and explored whether γ-irradiation which eliminates the clonogenic potential of stem and progenitor cells has an impact on BMC efficacy...
April 19, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28430785/medical-expulsive-therapy-for-ureter-stone-using-naftopidil-a-multicenter-randomized-double-blind-and-placebo-controlled-trial
#4
Sung Yong Cho, Woong Na, Sang Wook Lee, Min Chul Cho, Jong Jin Oh, Sangchul Lee, Juhyun Park, Soyeon Ahn, Chang Wook Jeong
OBJECTIVES: A prospective, multicenter, randomized, double-blind, placebo-controlled trial evaluated the effects of naftopidil 75 mg for medical expulsive therapy for a single ureter stone. MATERIALS AND METHODS: Patients diagnosed with a ureter stone were prescribed aceclofenac 100 mg or a combined medication of tramadol 37.5 mg and acetaminophen 325 mg. Patients then randomly received either naftopidil 75 mg or placebo. Primary endpoint was the stone passage rate at 14 days after medication...
2017: PloS One
https://www.readbyqxmd.com/read/28430684/flurbiprofen-axetil-provides-effective-analgesia-without-changing-the-pregnancy-rate-in-ultrasound-guided-transvaginal-oocyte-retrieval-a-double-blind-randomized-controlled-trial
#5
Hong Zhao, Yi Feng, Yan Jiang, Qun Lu
BACKGROUND: In this prospective double-blind randomized study, we evaluated the analgesic effect and potential effect on pregnancy rate of the nonsteroidal anti-inflammatory drug flurbiprofen axetil in patients undergoing ultrasound-guided transvaginal oocyte retrieval under propofol-remifentanil anesthesia. METHODS: A total of 200 patients scheduled to undergo ultrasound-guided transvaginal oocyte retrieval were randomly allocated to receive 1.5 mg/kg of flurbiprofen axetil (FA group) or placebo (control group) 30 minutes before the procedure...
April 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28430159/efficacy-of-low-molecular-weight-fucoidan-as-a-supplemental-therapy-in-metastatic-colorectal-cancer-patients-a-double-blind-randomized-controlled-trial
#6
Hsiang-Lin Tsai, Chi-Jung Tai, Ching-Wen Huang, Fang-Rong Chang, Jaw-Yuan Wang
BACKGROUND: Low-molecular-weight fucoidan (LMF) is widely used as a food supplement for cancer patients. However, all of the studies are in vitro or were conducted using mice. Therefore, powerful clinical evidence for LMF use is relatively weak. This study aimed to evaluate the efficacy of LMF as a supplemental therapy to chemo-target agents in metastatic colorectal cancer (mCRC) patients. METHODS: We conducted a prospective, randomized, double-blind, controlled trial to evaluate the efficacy of LMF as a supplemental therapy to chemotarget agents in patients with metastatic colorectal cancer (mCRC)...
April 21, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28429998/the-efficacy-of-a-pre-workout-vegan-supplement-on-high-intensity-cycling-performance-in-healthy-college-aged-males
#7
Gabrielle Gallien, David Bellar, Greggory R Davis
There is a limited supply of sport nutrition supplements currently available for vegan or vegetarian athletes. In addition, the efficacy of a vegan or vegetarian pre-workout supplement that does not contain any processed ingredients or stimulants is currently unknown. The purpose of the current study was to examine the effects of an unprocessed vegan pre-workout supplement on high-intensity cycling performance. Participants completed three separate cycling trials following the consumption of a vegan pre-workout supplement, an isocaloric processed supplement, or a zero-calorie placebo supplement...
April 21, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28429904/effect-of-lutein-supplementation-on-visual-function-in-nonproliferative-diabetic-retinopathy
#8
Ping-Chuan Zhang, Chang-Rui Wu, Zhi-Lun Wang, Li-Yuan Wang, Yue Han, Shu-Liu Sun, Qing-Shan Li, Le Ma
BACKGROUND AND OBJECTIVES: The purpose of this study was to determine whether supplementation with lutein improved visual function in patients with nonproliferative diabetic retinopathy (NPDR). METHODS AND STUDY DESIGN: In this randomized, double-blind, placebo-controlled trial, 31 patients with NPDR were assigned randomly to 10 mg/d of lutein or identical placebo for 36 weeks. Visual performance indices, including visual acuity (VA), contrast sensitivity (CS) and glare sensitivity (GS) at four different spatial frequencies, were measured at baseline, week 18 and 36...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28429843/pooled-analysis-of-three-randomized-double-blind-placebo-controlled-trials-with-rimonabant-for-smoking-cessation
#9
Jason D Robinson, Paul M Cinciripini, Maher Karam-Hage, Henri-Jean Aubin, Lowell C Dale, Raymond Niaura, Robert M Anthenelli
Despite the withdrawal of CB1 antagonists, such as rimonabant, from the market and from active clinical development because of concerns about their side effect profiles, research suggests that the endocannabinoid system may play an important role in modulating nicotine's effects. We report the combined results, using a pooled analysis, of three previously unpublished trials assessing rimonabant as a smoking cessation pharmacotherapy conducted between 2002 and 2004. Smokers (n = 2097) motivated to quit were enrolled in three randomized, double-blind, placebo-controlled trials, STRATUS EU, US, and META, which consisted of a 10-week treatment period with either rimonabant 20 mg (n = 789), 5 mg (n = 518; used in only two of the three studies), or placebo (n = 790), in conjunction with brief counseling...
April 21, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28429539/what-should-the-optimal-intrauterine-pressure-be-during-outpatient-diagnostic-hysteroscopy-a-randomized-comparative-study
#10
Erbil Karaman, Ali Kolusarı, Orkun Çetin, Numan Çim, İsmet Alkış, Yasemin Karaman, Seyithan Güler
AIM: The aim of this study was to evaluate and compare lower and higher uterine filling pressures during outpatient diagnostic hysteroscopy. METHODS: One hundred and seventy-five women eligible for outpatient diagnostic hysteroscopy were included in this randomized double blind comparative study. The subjects were randomized into two groups. Group 1 (n = 80) underwent surgery with lower intrauterine filling pressures (30, 40, and 50 mmHg) and group 2 (n = 81) underwent surgery with higher filling pressures (70, 80, and 100 mmHg)...
April 20, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28429134/systematic-review-of-quality-of-life-and-functional-outcomes-in-randomized-placebo-controlled-studies-of-medications-for-attention-deficit-hyperactivity-disorder
#11
REVIEW
David R Coghill, Tobias Banaschewski, César Soutullo, Matthew G Cottingham, Alessandro Zuddas
Children, adolescents and adults with attention-deficit/hyperactivity disorder (ADHD) experience functional impairment and poor health-related quality of life (HRQoL) in addition to symptoms of inattention/hyperactivity-impulsivity. To synthesize qualitatively the published evidence from randomized, double-blind, placebo-controlled trials of the effectiveness of pharmacotherapy on functional impairment or HRQoL in patients with ADHD, a systematic PubMed searching and screening strategy was designed to identify journal articles meeting pre-specified criteria...
April 20, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28427929/corrigendum-to-long-term-cariprazine-treatment-for-the-prevention-of-relapse-in-patients-with-schizophrenia-a-randomized-double-blind-placebo-controlled-trial-schizophr-res-176-2016-264-271
#12
Suresh Durgam, Willie Earley, Rui Li, Dayong Li, Kaifeng Lu, István Laszlovszky, W Wolfgang Fleischhacker, Henry A Nasrallah
No abstract text is available yet for this article.
April 17, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28427826/suvorexant-in-elderly-patients-with-insomnia-pooled-analyses-of-data-from-phase-iii-randomized-controlled-clinical-trials
#13
W Joseph Herring, Kathryn M Connor, Ellen Snyder, Duane B Snavely, Ying Zhang, Jill Hutzelmann, Deborah Matzura-Wolfe, Ruth M Benca, Andrew D Krystal, James K Walsh, Christopher Lines, Thomas Roth, David Michelson
OBJECTIVE: Suvorexant is an orexin receptor antagonist approved for treating insomnia at doses of 10-20 mg. Previously reported phase III results showed that suvorexant was effective and well-tolerated in a combined-age population (elderly and nonelderly adults). The present analysis evaluated the clinical profile of suvorexant specifically in the elderly. METHODS: Prespecified subgroup analyses of pooled 3-month data from two (efficacy) and three (safety) randomized, double-blind, placebo-controlled, parallel-group trials...
March 8, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28427403/preoperative-carbohydrate-load-and-intraoperatively-infused-omega-3-polyunsaturated-fatty-acids-positively-impact-nosocomial-morbidity-after-coronary-artery-bypass-grafting-a-double-blind-controlled-randomized-trial
#14
Gibran Roder Feguri, Paulo Ruiz Lúcio de Lima, Danilo de Cerqueira Borges, Laura Ramos Toledo, Larissa Nadaf Batista, Thaís Carvalho E Silva, Neuber José Segri, José Eduardo de Aguilar-Nascimento
BACKGROUND: A strategy of limited preoperative fasting, with carbohydrate (CHO) loading and intraoperative infusion of omega-3 polyunsaturated fatty acids (ω-3 PUFA), has seldom been tried in cardiovascular surgery. Brief fasting, followed by CHO intake 2 h before anesthesia, may improve recovery from CABG procedures and lower perioperative vasoactive drug requirements. Infusion of ω-3 PUFA may reduce occurrences of postoperative atrial fibrillation (POAF) and shorten hospital stays...
April 20, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28426903/the-therapeutic-efficacy-of-botulinum-toxin-in-treating-scleroderma-associated-raynaud-s-phenomenon-a-randomized-double-blind-placebo-controlled-clinical-trial-assessing
#15
Ricardo J Bello, Carisa M Cooney, Eitan Melamed, Keith Follmar, Gayane Yenokyan, Gwendolyn Leatherman, Ami A Shah, Fredrick M Wigley, Laura K Hummers, Scott D Lifchez
Objective To assess the therapeutic efficacy of local injections with Botulinum Toxin Type-A (Btx-A) in improving blood flow to the hands of patients with Raynaud's Phenomenon (RP) secondary to scleroderma. Methods In this randomized, double-blind, placebo-controlled clinical trial (http://ClinicalTrials.gov #NCT02165111), patients with scleroderma-associated RP received Btx-A (50 units in 2.5 mL) in one randomly selected hand and sterile saline (2.5 mL) in the opposite hand. Follow-up at 1 and 4 months post-injection included Laser Doppler Imaging (LDI) of hands, patient-reported outcomes, and physical exam...
April 20, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28426476/autologous-myoblasts-for-the-treatment-of-fecal-incontinence-results-of-a-phase-2-randomized-placebo-controlled-study-mias
#16
Olivier Boyer, Valérie Bridoux, Camille Giverne, Aurélie Bisson, Edith Koning, Anne-Marie Leroi, Pascal Chambon, Justine Déhayes, Stephanie Le Corre, Serge Jacquot, Dominique Bastit, Jérémie Martinet, Estelle Houivet, Jean-Jacques Tuech, Jacques Benichou, Francis Michot
OBJECTIVE: The aim of this study was to evaluate the efficacy of intrasphincteric injections of autologous myoblasts (AMs) in fecal incontinence (FI) in a controlled study. SUMMARY OF BACKGROUND DATA: Adult stem cell therapy is expected to definitively cure FI by regenerating damaged sphincter. Preclinical data and results of open-label trials suggest that myoblast therapy may represent a noninvasive treatment option. METHODS: We conducted a phase 2 randomized, double-blind, placebo-controlled study of intrasphincteric injections of AM in 24 patients...
April 19, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28425672/evaluating-therapeutic-effect-on-womac-subscales-in-osteoarthritis-rcts-when-model-choice-matters
#17
Giulia Lorenzoni, Danila Azzolina, Nicola Soriani, Dario Gregori
RATIONALE, AIMS, AND OBJECTIVES: The study aimed at developing a method for modelling the Western Ontario and McMaster Universities index (WOMAC), accounting for correlation between its subscales and for heterogeneity of treatment effect (HTE), using data from 2 twin trials on knee osteoarthritis. METHOD: Two randomized, double-blind, placebo-controlled clinical trials (twin trials). Studies aimed at investigating the effectiveness of a pharmacological treatment on clinical outcomes of knee osteoarthritis, measured using WOMAC index...
April 20, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28425497/single-dose-memantine-improves-cortical-oscillatory-response-dynamics-in-patients-with-schizophrenia
#18
Gregory A Light, Wen Zhang, Yash B Joshi, Savita Bhakta, Jo A Talledo, Neal R Swerdlow
Aberrant gamma band (30-80 Hz) oscillations may underlie cognitive deficits in schizophrenia (SZ). Gamma oscillations and their regulation by NMDA receptors can be studied via their evoked power (γEP) and phase locking (γPL) in response to auditory steady state stimulation; these Auditory Steady State Responses (ASSRs) may be biomarkers for target engagement and early therapeutic effects. We previously reported that memantine, an NMDA receptor antagonist, enhanced 2 biomarkers of early auditory information processing: prepulse inhibition (PPI) and mismatch negativity (MMN) in SZ patients and healthy subjects (HS)...
April 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28424190/odd-chain-fatty-acids-as-a-biomarker-for-dietary-fiber-intake-a-novel-pathway-for-endogenous-production-from-propionate
#19
Karolin Weitkunat, Sara Schumann, Daniela Nickel, Silke Hornemann, Klaus J Petzke, Matthias B Schulze, Andreas Fh Pfeiffer, Susanne Klaus
Background: The risk of type 2 diabetes is inversely correlated with plasma concentrations of odd-chain fatty acids [OCFAs; pentadecanoic acid (15:0) and heptadecanoic acid (17:0)], which are considered as biomarkers for dairy fat intake in humans. However, rodent studies suggest that OCFAs are synthesized endogenously from gut-derived propionate. Propionate increases with dietary fiber consumption and has been shown to improve insulin sensitivity.Objective: We hypothesized that OCFAs are produced in humans from dietary fibers by a novel endogenous pathway...
April 19, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28424185/very-long-chain-%C3%AF-3-fatty-acid-supplements-and-adipose-tissue-functions-a-randomized-controlled-trial
#20
Kazanna C Hames, Maria Morgan-Bathke, Debra A Harteneck, Lendia Zhou, John D Port, Ian R Lanza, Michael D Jensen
Background: Increased omega-3 (n-3) fatty acid consumption is reported to benefit patients with metabolic syndrome, possibly due to improved adipose tissue function.Objective: We tested the effects of high-dose, very-long-chain ω-3 fatty acids on adipose tissue inflammation and insulin regulation of lipolysis.Design: A double-blind, placebo-controlled study compared 6 mo of 3.9 g eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)/d (4.2 g total ω-3/d; n = 12) with a placebo (4.2 g oleate/d; n = 9) in insulin-resistant adults...
April 19, 2017: American Journal of Clinical Nutrition
keyword
keyword
63876
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"