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Hao-Jui Hsu, Helena Palka-Hamblin, Gaurang P Bhide, Ja-Hye Myung, Michael Cheong, Karen J Colley, Seungpyo Hong
Enumeration of circulating tumor cells (CTCs) of small-cell lung cancer (SCLC) patients has been shown to predict the disease progress and long-term survival. Most CTC detection methods rely on epithelial surface markers, such as epithelial cell adhesion molecule (EpCAM). However, this marker in SCLC is reported to be often downregulated after a variety of phenotypic changes, which impairs the reliability of EpCAM-based CTC detections. In this regard, the development of an alternative CTC detection method involving different CTC surface markers is in demand...
March 20, 2018: Analytical Chemistry
Rafael Maldonado, Josep Eladi Baños, David Cabañero
Several lines of knockout mice deficient in the genes encoding each component of the endogenous opioid system have been used for decades to clarify the specific role of the different opioid receptors and peptide precursors in many physiopathological conditions. The use of these genetically modified mice has improved our knowledge of the specific involvement of each endogenous opioid component in nociceptive transmission during acute and chronic pain conditions. The present review summarizes the recent advances obtained using these genetic tools in understanding the role of the opioid system in the pathophysiological mechanisms underlying chronic pain...
November 10, 2017: British Journal of Pharmacology
T-T Ng, D Diamantaras, J Priestley, J Redman, N De Silva, V Mahanta
OBJECTIVE: To evaluate the efficacy and safety of celecoxib for pain management in post-tonsillectomy adult patients. DESIGN: A randomised, double-blind, placebo-controlled, phase 3 clinical trial was conducted in an adult population (aged 18-55 years), with a parallel group design using an allocation ratio of 1:1. METHODS: Eighty patients underwent elective tonsillectomy or adenotonsillectomy, operated on by one surgeon. They were discharged home with randomly assigned celecoxib or placebo, together with regular post-tonsillectomy medications (paracetamol and Endone)...
January 2017: Journal of Laryngology and Otology
Danuta Mendelson
This study examined 27 reports from disciplinary tribunals throughout Australia (save Tasmania where reports were not accessible) against medical practitioners who abused narcotic analgesics (often combined with other drugs of addiction) between 2010 and 2015. The reports revealed that 12 medical practitioners were in their 40s; five in their 30s; and one person still in their 20s. Although the majority were general practitioners (15 out of 27), other medical specialties were also represented. Self-administered pethidine was the most prevalent opioid (11 out of 27) and was the only drug used alone...
September 2015: Journal of Law and Medicine
Xiuli Mao, Yuntao Zhang, Tyler Schwend, Gary W Conrad
Sensory trigeminal growth cones innervate the cornea in a coordinated fashion during embryonic development. Polysialic acid (polySia) is known for its important roles during nerve development and regeneration. The purpose of this work is to determine whether polySia, present in developing eyefronts and on the surface of sensory nerves, may provide guidance cues to nerves during corneal innervation. Expression and localization of polySia in embryonic day (E)5-14 chick eyefronts and E9 trigeminal ganglia were identified using Western blotting and immunostaining...
February 15, 2015: Developmental Biology
P Zeman, K Koudela, J Kasl, P Nepraš, J Zeman, J Matějka
PURPOSE OF THE STUDY: The aim of the study is to present a comparison of short-term results of double- versus single-bundle anatomical reconstruction of the anterior cruciate ligament (ACL) using hamstring endons and their fixation with absorbable interference screws. MATERIAL AND METHODS: A total of 110 patients with an isolated ACL lesion and the healthy contralateral knee who met the indication criteria for ACL double bundle reconstruction (TISL, 14 mm; ICNW, 12 mm) were intra-operatively allocated at random to either double-bundle group (DB, n=55) or single-bundle group (SB, n=55)...
2014: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
Atsunori Tsuchiya, Wei-Yu Lu, Birgit Weinhold, Luke Boulter, Benjamin M Stutchfield, Michael J Williams, Rachel V Guest, Sarah E Minnis-Lyons, Alison C MacKinnon, David Schwarzer, Takafumi Ichida, Minoru Nomoto, Yutaka Aoyagi, Rita Gerardy-Schahn, Stuart J Forbes
UNLABELLED: In severe liver injury, ductular reactions (DRs) containing bipotential hepatic progenitor cells (HPCs) branch from the portal tract. Neural cell adhesion molecule (NCAM) marks bile ducts and DRs, but not mature hepatocytes. NCAM mediates interactions between cells and surrounding matrix; however, its role in liver development and regeneration is undefined. Polysialic acid (polySia), a unique posttranslational modifier of NCAM, is produced by the enzymes, ST8SiaII and ST8SiaIV, and weakens NCAM interactions...
November 2014: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Susumu Ohmae
In 1961, Tellenbach published the concept of "Typus melancholicus" (melancholic type) to illustrate the complementary relationship between premelancholic (predepressive) situations and a premorbid personality. The melancholic type is often considered to be a non-universal type that is localized in Germany and Japan; however, this belief is increasingly considered to be incorrect. When referring to papers written in the United States around the time that Tellenbach's monograph was published, it is now possible to identify some personalities corresponding to the melancholic type...
2013: Seishin Shinkeigaku Zasshi, Psychiatria et Neurologia Japonica
Ramon Guirado, Marta Perez-Rando, David Sanchez-Matarredona, Esther Castillo-Gómez, Teresa Liberia, Laura Rovira-Esteban, Emilio Varea, Carlos Crespo, José Miguel Blasco-Ibáñez, Juan Nacher
Excitatory neurons undergo dendritic spine remodeling in response to different stimuli. However, there is scarce information about this type of plasticity in interneurons. The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is a good candidate to mediate this plasticity as it participates in neuronal remodeling and is expressed by some mature cortical interneurons, which have reduced dendritic arborization, spine density, and synaptic input. To study the connectivity of the dendritic spines of interneurons and the influence of PSA-NCAM on their dynamics, we have analyzed these structures in a subpopulation of fluorescent spiny interneurons in the hippocampus of glutamic acid decarboxylase-enhanced green fluorescent protein transgenic mice...
November 2014: Cerebral Cortex
Stavros A Antoniou, George A Antoniou, Christos Koutras, Athanasios I Antoniou
INTRODUCTION: The history of medical terminology is interrelated with the scientific advances in the field. Efforts to explore human cavities for diagnostic and therapeutic purposes began as early as the 5th century BC. The evolution of laparoscopy at the beginning of the past century has been a major step toward minimization of surgical trauma. The present article investigates the terminological origin and the evolution of the terms endoscopy and laparoscopy. METHODS: A search of ancient bibliographical archives and a review of the modern medical literature was undertaken...
December 2012: Surgical Endoscopy
Alessandra Ambrosini, Giovanni Stanghellini, Alvaro I Langer
The concept of Typus Melancholicus (TM) was shaped by Tellenbach to describe the premorbid and intermorbid personality vulnerable to endogenous depression. The first part of this paper aims to point out the basic principles of Tellenbach’s theory – the method, the concept of endon, of rhythmic, of situation, of rimanence, of includence and of despair. Then, we present a systematic description of the premorbid personality features - orderliness, conscientiousness, hyper/hetereonomia and intolerance of ambiguity...
September 2011: Actas Españolas de Psiquiatría
Gary Winship
This paper reconvenes Samuel Beckett's psychotherapy with Wilfred Bion during 1934-1936 during which time Beckett's conceived and began writing this second novel, Murphy. Based on Beckett's visits to the Bethlem & Maudsley Hospital and his observation of the male nurses, the climax of Murphy is a chess match between Mr Endon (a male schizophrenic patient) and Murphy (a male psychiatric nurse). The precise notation of the Endon v Murphy chess match tells us that the Beckett intended it to be an exemplar of an anti-match, perhaps a metaphor for the tragedy of being locked into madness...
December 2011: Journal of Medical Humanities
Rebeca Ramírez González, María Virgilia Soto Abraham, Antonio Ugalde Viteli, César Pacheco Tena, Rubén Burgos-Vargas
BACKGROUND: Foot involvement in patients with spondyloarthropathies (SpA) includes a peculiar clinical spectrum ranging from tarsal swelling to bone ankylosis similar to axial disease in patients with ankylosing spondylitis. Hypothetically, the study of these lesions could help to explain phenomena that occur in the vertebral column. OBJECTIVE: To identify the best site for sampling foot tissues in cadavers with a view to implementing the procedure in patients with SpA...
July 2006: Reumatología Clinica
D Endon, A G Sazykin
No abstract text is available yet for this article.
1984: Narody Azii i Afriki
Venceslas Duveau, Jean-Marc Fritschy
Polysialylated neuronal cell adhesion molecule (PSA-NCAM), a polysialylated protein constitutively expressed in the hippocampus, is involved in neuronal growth, synaptic plasticity and neurotrophin signaling. In particular, PSA-NCAM mediates Ret-independent glial-derived neurotrophic factor (GDNF) signaling, leading to downstream FAK activation. GDNF has potent seizure-suppressant action, whereas PSA-NCAM is upregulated by seizure activity. However, the involvement of Ret-independent GDNF signaling in temporal lobe epilepsy (TLE) is not established...
July 2010: European Journal of Neuroscience
Amandine Bery, Albert Cardona, Pedro Martinez, Volker Hartenstein
The neuroarchitecture of Acoela has been at the center of morphological debates. Some authors, using immunochemical tools, suggest that the nervous system in Acoela is organized as a commissural brain that bears little resemblance to the central, ganglionic type brain of other flatworms, and bilaterians in general. Others, who used histological staining on paraffin sections, conclude that it is a compact structure (an endonal brain; e.g., Raikova 2004; von Graff 1891; Delage Arch Zool Exp Gén 4:109-144, 1886)...
September 2010: Development Genes and Evolution
David Schwarzer, Katharina Stummeyer, Thomas Haselhorst, Friedrich Freiberger, Bastian Rode, Melanie Grove, Thomas Scheper, Mark von Itzstein, Martina Mühlenhoff, Rita Gerardy-Schahn
Endosialidases (endoNs), as identified so far, are tailspike proteins of bacteriophages that specifically bind and degrade the alpha2,8-linked polysialic acid (polySia) capsules of their hosts. The crystal structure solved for the catalytic domain of endoN from coliphage K1F (endoNF) revealed a functional trimer. Folding of the catalytic trimer is mediated by an intramolecular C-terminal chaperone domain. Release of the chaperone from the folded protein confers kinetic stability to endoNF. In mutant c(S), the replacement of serine 911 by alanine prevents proteolysis and generates an enzyme that varies in activity from wild type...
April 3, 2009: Journal of Biological Chemistry
Alison Burgess, Steven R Wainwright, Lamya S Shihabuddin, Urs Rutishauser, Tatsunori Seki, Isabelle Aubert
Newborn cells of the adult dentate gyrus in the hippocampus are characterized by their abundant expression of polysialic acid (PSA), a carbohydrate attached to the neural cell adhesion molecule (NCAM). PSA+ newborn cells of the dentate gyrus form clusters with proliferating neural progenitor cells, migrate away from these clusters, and terminally differentiate. To identify the roles of PSA in the development of adult progenitors of the dentate gyrus, we injected endoneuraminidase N (endoN) into the hippocampus of adult rats to specifically cleave PSA from NCAM...
December 2008: Developmental Neurobiology
Anton Pekcec, Christina Fuest, Martina Mühlenhoff, Rita Gerardy-Schahn, Heidrun Potschka
Polysialylation is a post-translational modification of the neural cell adhesion molecule (NCAM), which in the adult brain promotes structural changes in regions of neurogenesis and neuroplasticity. Because a variety of plastic changes including neurogenesis have been suggested to be functionally involved in the pathophysiology of epilepsies, it is of specific interest to define the impact of the polysialic acid (PSA)-NCAM system on development of this disease and associated comorbidities. Therefore, we studied the impact of transient enzymatic depolysialylation of NCAM on the pathophysiology in an electrically induced rat post-status epilepticus (SE) model...
April 2008: Journal of Neurochemistry
Alison Burgess, Ying-Qi Weng, Athéna Rebecca Ypsilanti, Xuezhi Cui, Geoffrey Caines, Isabelle Aubert
Polysialic acid (PSA) is a large carbohydrate found exclusively on the neural cell adhesion molecule (NCAM). In the adult brain, PSA is re-expressed by septal axons sprouting and regenerating in an environment rich in laminin. Using an in vitro model, we tested the possibility that PSA limits septal outgrowth by preventing maximal interactions with a laminin substrate. Our results indicate that PSA removal from primary septal neurons plated on laminin significantly increased neurite outgrowth at 12 h (14%, p<0...
May 4, 2007: Brain Research
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