Domenic H Cerri, Daniel L Albaugh, Lindsay R Walton, Brittany Katz, Tzu-Wen Wang, Tzu-Hao Harry Chao, Weiting Zhang, Randal J Nonneman, Jing Jiang, Sung-Ho Lee, Amit Etkin, Catherine N Hall, Garret D Stuber, Yen-Yu Ian Shih
The striatum, known as the input nucleus of the basal ganglia, is extensively studied for its diverse behavioral roles. However, the relationship between its neuronal and vascular activity, vital for interpreting functional magnetic resonance imaging (fMRI) signals, has not received comprehensive examination within the striatum. Here, we demonstrate that optogenetic stimulation of dorsal striatal neurons or their afferents from various cortical and subcortical regions induces negative striatal fMRI responses in rats, manifesting as vasoconstriction...
March 1, 2024: Nature Communications