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https://www.readbyqxmd.com/read/29133292/intracellular-hepatitis-b-virus-increases-hepatic-cholesterol-deposition-in-alcoholic-fatty-liver-via-hepatitis-b-core-protein
#1
Ya-Qi Wang, Ting Wu, Dan-Qing Hu, Xin-Xin Weng, Xiao-Jing Wang, Pei-Jer Chen, Xiao-Ping Luo, Hong-Wu Wang, Qin Ning
Hepatits B virus (HBV) infection is a prevalent infectious disease with serious outcomes like chronic and acute hepatitis, cirrhosis and hepatocellular carcinoma. However, the metabolic alteration by HBV is rarely taken into concerns. With the high prevalence of alcohol consumption and chronic HBV infection, their overlap is assumed as an increasing latent hazard although without exact calculation, moreover, the impact of chronic alcoholic consumption combined with HBV on cholesterol metabolism is unknown. Six-week-old male FVB/Ncrl mice were hydrodynamically injected with a pGEM-4Z-1...
November 13, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/29129819/nicotinic-acetylcholine-receptor-%C3%AE-7-subunit-improves-energy-homeostasis-and-inhibits-inflammation-in-nonalcoholic-fatty-liver-disease
#2
Dong-Jie Li, Jian Liu, Xia Hua, Hui Fu, Fang Huang, Yi-Bo Fei, Wen-Jie Lu, Fu-Ming Shen, Pei Wang
OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide; yet, the pathogenesis of the disorder is not completely understood. The nicotinic acetylcholine receptor α7 subunit (α7nAChR) plays an indispensable role in the vagus nerve-regulated cholinergic anti-inflammatory pathway. METHODS: In the present study, we investigated the key role of α7nAChR in NAFLD development. Male wild-type (WT) and α7nAChR knockout (α7nAChR(-/-)) mice were fed a normal chow or a high-fat diet (HFD) for 16 weeks to induce NAFLD...
November 9, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29125992/phenol-enriched-olive-oils-improve-hdl-antioxidant-content-in-hypercholesterolemic-subjects-a-randomized-double-blind-cross-over-controlled-trial
#3
Marta Farràs, Sara Fernández-Castillejo, Laura Rubió, Sara Arranz, Úrsula Catalán, Isaac Subirana, Mari-Paz Romero, Olga Castañer, Anna Pedret, Gemma Blanchart, Daniel Muñoz-Aguayo, Helmut Schröder, Maria-Isabel Covas, Rafael de la Torre, Maria-José Motilva, Rosa Solà, Montserrat Fitó
At present, high-density lipoprotein (HDL) function is thought to be more relevant than HDL cholesterol quantity. Consumption of olive oil phenolic compounds (PCs) has beneficial effects on HDL-related markers. Enriched food with complementary antioxidants could be a suitable option to obtain additional protective effects. Our aim was to ascertain whether virgin olive oils (VOOs) enriched with (a) their own PC (FVOO) and (b) their own PC plus complementary ones from thyme (FVOOT) could improve HDL status and function...
September 28, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29124388/measuring-the-impact-of-olive-pomace-enriched-biscuits-on-the-gut-microbiota-and-its-metabolic-activity-in-mildly-hypercholesterolaemic-subjects
#4
Lorenza Conterno, Francesca Martinelli, Matteo Tamburini, Francesca Fava, Andrea Mancini, Maddalena Sordo, Massimo Pindo, Stefan Martens, Domenico Masuero, Urska Vrhovsek, Claudia Dal Lago, Gabriele Ferrario, Mario Morandini, Kieran Tuohy
PURPOSE: Olive pomace is a major waste product of olive oil production but remains rich in polyphenols and fibres. We measured the potential of an olive pomace-enriched biscuit formulation delivering 17.1 ± 4.01 mg/100 g of hydroxytyrosol and its derivatives, to modulate the composition and metabolic activity of the human gut microbiota. METHODS: In a double-blind, controlled parallel dietary intervention 62 otherwise healthy hypercholesterolemic (total plasma cholesterol 180-240 mg/dl) subjects were randomly assigned to eat 90 g of olive pomace-enriched biscuit (olive-enriched product, OEP) or an isoenergetic control (CTRL) for 8 weeks...
November 9, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29119548/association-of-total-cholesterol-low-density-lipoprotein-cholesterol-and-non-high-density-lipoprotein-cholesterol-with-atherosclerotic-cardiovascular-disease-and-cancer-in-a-chinese-male-population
#5
Xu-Min Guan, Shou-Ling Wu, Xiao-Lei Yang, Xu Han, Yi-Heng Yang, Xin-Tao Li, BinWaleed Khalid, Yue Du, Si-Yan Zhan, Ying Liu, Hui-Hua Li, Yun-Long Xia
Objective The objective of this study was to investigate the association between total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and non-high-density lipoprotein cholesterol (non-HDL-C) with atherosclerotic cardiovascular disease (ASCVD) or cancer in a male population in the Kailuan cohort of China. Methods This prospective study included 68,769 Chinese male adults from Kailuan cohort of China who had a standardized medical examination between 2006 and 2007 and were followed up for approximately 8 years until occurrence of ASCVD, cancer or death or until December 31, 2014...
November 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29117670/association-between-dietary-intake-and-postlaparoscopic-cholecystectomic-symptoms-in-patients-with-gallbladder-disease
#6
Yongju Shin, Dongho Choi, Kyeong Geun Lee, Ho Soon Choi, Yongsoon Park
Background/Aims: After cholecystectomy, patients have reported postcholecystectomic syndromes such as abdominal symptoms, dyspepsia, and diarrhea, which suggest a relationship between cholecystectomic symptoms and diet, although the details of this association remain unclear. The present study investigated the hypothesis that dietary intake of nutrients and foods was significantly associated with postcholecystectomic syndromes. Methods: Gallstone patients (n = 59) who underwent laparoscopic cholecystectomy were enrolled, and dietary intake and clinical parameters were assessed immediately postcholecystectomy and 3 months later...
November 10, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29115200/barley-%C3%AE-glucan-reduces-blood-cholesterol-levels-via-interrupting-bile-acid-metabolism
#7
Yanan Wang, Scott V Harding, Sijo J Thandapilly, Susan M Tosh, Peter J H Jones, Nancy P Ames
Underlying mechanisms responsible for the cholesterol-lowering effect of β-glucan have been proposed, yet have not been fully demonstrated. The primary aim of this study was to determine whether the consumption of barley β-glucan lowers cholesterol by affecting the cholesterol absorption, cholesterol synthesis or bile acid synthesis. In addition, this study was aimed to assess whether the underlying mechanisms are related to cholesterol 7α hydroxylase (CYP7A1) SNP rs3808607 as proposed by us earlier. In a controlled, randomised, cross-over study, participants with mild hypercholesterolaemia (n 30) were randomly assigned to receive breakfast containing 3 g high-molecular weight (HMW), 5 g low-molecular weight (LMW), 3 g LMW barley β-glucan or a control diet, each for 5 weeks...
November 8, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29113145/associations-between-nut-consumption-and-health-vary-between-omnivores-vegetarians-and-vegans
#8
Rachel C Brown, Andrew R Gray, Siew Ling Tey, Alexandra Chisholm, Victoria Burley, Darren C Greenwood, Janet Cade
Regular nut consumption is associated with reduced risk factors for chronic disease; however, most population-based studies lack consideration of effect modification by dietary pattern. The UK Women's Cohort Study (UKWCS) provides an ideal opportunity to examine relationships between nut consumption and chronic disease risk factors in a large sample with diverse dietary patterns. Nut and nutrient intake from 34,831 women was estimated using a food frequency questionnaire among self-identified omnivores, vegetarians and vegans...
November 6, 2017: Nutrients
https://www.readbyqxmd.com/read/29113113/dietary-pattern-during-1991-2011-and-its-association-with-cardio-metabolic-risks-in-chinese-adults-the-china-health-and-nutrition-survey
#9
Ming Li, Zumin Shi
Increased prevalence of overweight and obesity, diabetes, hypertension, and other cardio metabolic risks has become a public health concern in China, a country undergoing nutrition transition. We investigated the dietary pattern during 1991-2011 and its association with these risks in a longitudinal study among adults; Adults in The China Health and Nutrition Survey were included. Three-day food consumption was collected by 24 h recall method. Anthropometric measures, blood pressure, fasting blood glucose and lipids was collected in 2009...
November 6, 2017: Nutrients
https://www.readbyqxmd.com/read/29111915/effects-of-egg-consumption-on-blood-lipids-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#10
Mohammad Hossein Rouhani, Nafiseh Rashidi-Pourfard, Amin Salehi-Abargouei, Majid Karimi, Fahimeh Haghighatdoost
BACKGROUND: It is widely agreed that egg consumption only modestly influences serum lipid concentrations. However, there is no meta-analysis summarizing existing randomized controlled trials. OBJECTIVE: The purpose of this study was to conduct a meta-analysis of published randomized controlled trials to explore the quantitative effect of egg consumption on serum lipid concentrations. DESIGN: Online databases including MEDLINE, Proquest and Google Scholar were systematically searched...
November 7, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29111079/phytosterol-enriched-milk-lowers-ldl-cholesterol-levels-in-brazilian-children-and-adolescents-double-blind-cross-over-trial
#11
S A Ribas, R Sichieri, A S B Moreira, D O Souza, C T F Cabral, D T Gianinni, D B Cunha
BACKGROUND AND AIMS: Despite evidence of the lipid-lowering effect of plant sterols among adults with hypercholesterolemia, data regarding phytosterol use in children are limited. In this paper, we examined the effects of daily consumption of a phytosterol-enriched milk compound on the lipid profiles of Brazilian children and adolescents with dyslipidemia. METHODS AND RESULTS: This was a randomized, double blind, crossover clinical trial. Twenty eight dyslipidemics outpatients (aged 6-9 years) from an University Hospital were randomly allocated to control or intervention group...
October 2, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29110223/the-effectiveness-and-cost-effectiveness-of-plant-sterol-or-stanol-enriched-functional-foods-as-a-primary-prevention-strategy-for-people-with-cardiovascular-disease-risk-in-england-a-modeling-study
#12
Wei Yang, Heather Gage, Daniel Jackson, Monique Raats
This study appraises the effectiveness and cost-effectiveness of consumption of plant sterol-enriched margarine-type spreads for the prevention of cardiovascular disease (CVD) in people with hypercholesterolemia in England, compared to a normal diet. A nested Markov model was employed using the perspective of the British National Health Service (NHS). Effectiveness outcomes were the 10-year CVD risk of individuals with mild (4-6 mmol/l) and high (above 6 mmol/l) cholesterol by gender and age groups (45-54, 55-64, 65-74, 75-85 years); CVD events avoided and QALY gains over 20 years...
November 6, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/29108343/effect-of-amygdalus-scoparia-kernel-oil-consumption-on-lipid-profile-of-the-patients-with-dyslipidemia-a-randomized-open-label-controlled-clinical-trial
#13
Mohammad Javad Zibaeenezhad, Maryam Shahamat, Seyed Hamdollah Mosavat, Armin Attar, Ehsan Bahramali
Background: Amygdalus scoparia kernel (ASK) oil is traditionally used for Hyperlipidemia. Compared to olive oil, it has higher proportion of unsaturated to saturated fatty acid besides exhibiting higher index of oxidative stability. The lipid-lowering effects of ASK oil however, has not been investigated yet. This study is the first one to evaluate such effects in patients with dyslipidemia. Results: Serum triglyceride levels significantly decreased in the intervention compared to control group (24...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29106496/transplantation-of-brown-adipose-tissue-inhibits-atherosclerosis-in-apoe-mice-contribution-of-the-activated-fgf-21-adiponectin-axis
#14
Masakazu Kikai, Hiroyuki Yamada, Noriyuki Wakana, Kensuke Terada, Keita Yamamoto, Naotoshi Wada, Shinichiro Motoyama, Makoto Saburi, Takeshi Sugimoto, Daisuke Irie, Taku Kato, Hiroyuki Kawahito, Takehiro Ogata, Satoaki Matoba
Aims: Brown adipose tissue (BAT) has been identified as an endocrine organ that maintains metabolic homeostasis; however, the effects on atherosclerosis remain undefined. Here, we investigated the effect of experimental BAT transplantation on atherosclerosis. Methods and Results: Interscapular BAT was dissected from 12-week-old wild-type mice and transplanted into the visceral cavity of 12-week-old apoE-/- mice. Oil-red O staining of whole aortas after 3 months of a high-cholesterol diet showed a significant decrease in atherosclerotic lesion area in BAT-transplanted mice by 20% compared with the sham control mice...
November 2, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29098747/predictors-of-adherence-to-treatment-by-patients-with-coronary-heart-disease-after-percutaneous-coronary-intervention
#15
Outi Kähkönen, Terhi Saaranen, Päivi Kankkunen, Marja-Leena Lamidi, Helvi Kyngäs, Heikki Miettinen
AIM AND OBJECTIVES: To identify the predictors of adherence in patients with coronary heart disease after a percutaneous coronary intervention. BACKGROUND: Adherence is a key factor in preventing the progression of coronary heart disease. DESIGN: An analytical multi-hospital survey study. METHODS: A survey of 416 post-percutaneous coronary intervention patients was conducted in 2013, using the Adherence of People with Chronic Disease Instrument...
November 3, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29096742/hmgcr-and-apoe-mutations-may-cause-different-responses-to-lipid-lowering-statin-therapy
#16
D Kirac, E Bayam, M Dagdelen, H Gezmis, S Sarikaya, S Pala, E C Altunok, E Genc
Coronary artery disease (CAD) and its complications are the major causes of death in the world. Although statins have been used to lower lipid levels in CAD patients, this goal can not be attained in 1/3 of the patients. The objective of this study was to investigate whether common variations in HMG-CoA Reductase(HMGCR) and Apolipoprotein E (ApoE) genes involved in lipid and statin metabolism modify the effect of statins on serum lipid and lipoprotein concentrations in CAD patients.A hundred  CAD patients were enrolled into the study...
October 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29095011/consumption-of-nutrients-with-antioxidant-action-and-its-relationship-with-lipid-profile-and-oxidative-stress-in-student-users-of-a-university-restaurant
#17
Sueli Maria Teixeira Lima, Kaluce Gonçalves De Sousa Almondes, Kyria Jayanne Clímaco Cruz, Heila Dias de Sousa Pinho Aguiar, Camila Maria Simplício Revoredo, Betzabeth Slater, Jennifer Beatriz Silva Morais, Dilina Do Nascimento Marreiro, Nadir Do Nascimento Nogueira
INTRODUCTION: The relationship between diet and health has aroused scientific interest, especially the consumption of antioxidant nutrients naturally present in foods, because of its action against the deleterious effects of free radicals in the body. OBJECTIVE: This study aimed to estimate the intake of antioxidant nutrients and its relationship with lipid profile and oxidative stress in student users of a university restaurant in comparison with non-users. METHODS: This cross-sectional study involved 145 university students divided into two groups: users of the university restaurant (group 1, n = 73) and non-users (group 2, n = 72)...
July 28, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29089335/the-effects-of-periconceptional-maternal-alcohol-intake-and-a-postnatal-high-fat-diet-on-obesity-and-liver-disease-in-male-and-female-rat-offspring
#18
Emelie M Gardebjer, James S M Cuffe, Leigh C Ward, Sarah Steane, Stephen T Anderson, Emily S Dorey, Jacinta I Kalisch-Smith, Marie Pantaleon, Suyinn Chong, Lisa Yamada, Mary E Wlodek, Helle Bielefeldt-Ohmann, Karen M Moritz
The effects of maternal alcohol consumption around the time of conception on offspring are largely unknown and difficult to determine in a human population. This study utilized a rodent model to examine if periconceptional alcohol (PC:EtOH), alone or in combination with a postnatal high-fat diet (HFD) resulted in obesity and liver dysfunction. Sprague-Dawley rats were fed a control or ethanol-containing liquid diet (12.5% EtOH v/v) from 4 days prior to mating until 4 days of gestation (n=12/group). A subset of offspring was fed a HFD between 3-8 months of age...
October 31, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29082745/cross-sectional-stepwise-approach-to-surveillance-steps-population-survey-of-noncommunicable-diseases-ncds-and-risk-factors-in-brunei-darussalam-2016
#19
Sok King Ong, Daphne Teck Ching Lai, Justin Yun Yaw Wong, Khairil Azhar Si-Ramlee, Lubna Abdul Razak, Norhayati Kassim, Zakaria Kamis, David Koh
This article provides a cross-sectional weighted measurement of noncommunicable diseases (NCDs) and risk factors prevalence among Brunei adult population using WHO STEPS methodology. A 2-staged randomized sampling was conducted during August 2015 to April 2016. Three-step surveillance included (1) interview using standardized questionnaire, (2) blood pressure and anthropometric measurements, and (3) biochemistry tests. Data weighting was applied. A total of 3808 adults aged 18 to 69 years participated in step 1; 2082 completed steps 2 and 3 measurements...
October 1, 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/29082640/achieving-ada-ispad-clinical-guideline-goals-is-associated-with-higher-insulin-sensitivity-and-cardiopulmonary-fitness-in-adolescents-with-type-1-diabetes-results-from-resistance-to-insulin-in-type-1-and-type-2-diabetes-resistant-and-effects-of-metformin-on
#20
Petter Bjornstad, Melanie Cree-Green, Amy Baumgartner, Gregory Coe, Yesenia Garcia Reyes, Michal Schäfer, Laura Pyle, Judith G Regensteiner, Jane Eb Reusch, Kristen J Nadeau
OBJECTIVE: Most youth with type 1 diabetes do not meet the American Diabetes Association (ADA) and International Society for Pediatric and Adolescent Diabetes (ISPAD) targets for hemoglobin A1c (HbA1c), blood pressure (BP), lipids, and body mass index (BMI). We hypothesized that ISPAD/ADA goal achievement would be associated with better insulin sensitivity (IS) and cardiopulmonary fitness. METHODS: IS was quantified as glucose infusion rate (GIR) from a hyperinsulinemic-euglycemic clamp in youth with type 1 diabetes from the RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) (n = 86) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) (n = 41) cohorts (n = 127; age 15...
October 30, 2017: Pediatric Diabetes
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