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https://www.readbyqxmd.com/read/27508751/-op-5c-04-heart-rate-is-associated-with-glomerular-hyperfiltration-in-apparently-healthy-subjects
#1
A Vrdoljak, V Ivkovic, S Karanovic, Z Dika, V Domislovic, K Dapic, L Gallineo, E Ivandic, J Josipovic, I Vukovic, J Kos, M Laganovic, T Zeljkovic Vrkic, M Fistrek Prlic, I Pecin, M Fucek, J Sertic, N Leko, B Jelakovic
OBJECTIVE: Glomerular hyperfiltration (GHF) was associated with progression of kidney disease and hypertension (HT). It was reported that high metabolic risk is related to increase of GHF. Our aim was to analyze in apparently healthy subjects which factor(s) influence (s) GHF and determine(s) clinical course in long-term prospective study. DESIGN AND METHOD: Out of 954 subjects enrolled in ENAH follow-up study, 371 (137 m, 234w; mean age = 46years) were eligible for further analysis:100 with optimal, 72 with normal BP, 70 with PHT (high normal BP), and 129 with newly diagnosed untreated HT...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27508620/-op-2b-03-glomerular-hyperfiltration-as-a-risk-factor-for-renal-impairment-and-hypertension-in-apparently-healthy-subjects
#2
A Vrdoljak, V Ivkovic, S Karanovic, Z Dika, V Domislovic, K Dapic, L Gallineo, E Ivandic, J Josipovic, I Vukovic, J Kos, M Laganovic, T Zeljkovic Vrkic, M Fistrek Prlic, I Pecin, M Fucek, J Sertic, N Leko, B Jelakovic
OBJECTIVE: Chronic kidney disease(CKD) is established CV risk factor, and already early renal impairment(RI) increases risk for hypertension(HT) and loss of renal function. It was reported that blood pressure (BP) and metabolic derangements are associated with glomerular hyperfiltration(GHF), and GHF increases risk of developing microalbuminuria (MA) in HT stage 1. Our aim was to analyze whether GHF predicts progression to HT and RI in apparently healthy subjects. DESIGN AND METHOD: Out of 954 subjects enrolled in ENAH follow-up study, 371 (137 m, 234 w; mean age = 46 years) were eligible for further analysis:100 with optimal, 72 with normal BP, 70 with PHT (high normal BP), and 129 with newly diagnosed untreated HT...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27216013/palaeolithic-diet-decreases-fasting-plasma-leptin-concentrations-more-than-a-diabetes-diet-in-patients-with-type-2-diabetes-a-randomised-cross-over-trial
#3
Maelán Fontes-Villalba, Staffan Lindeberg, Yvonne Granfeldt, Filip K Knop, Ashfaque A Memon, Pedro Carrera-Bastos, Óscar Picazo, Madhvi Chanrai, Jan Sunquist, Kristina Sundquist, Tommy Jönsson
BACKGROUND: We have previously shown that a Palaeolithic diet consisting of the typical food groups that our ancestors ate during the Palaeolithic era, improves cardiovascular disease risk factors and glucose control compared to the currently recommended diabetes diet in patients with type 2 diabetes. To elucidate the mechanisms behind these effects, we evaluated fasting plasma concentrations of glucagon, insulin, incretins, ghrelin, C-peptide and adipokines from the same study. METHODS: In a randomised, open-label, cross-over study, 13 patients with type 2 diabetes were randomly assigned to eat a Palaeolithic diet based on lean meat, fish, fruits, vegetables, root vegetables, eggs and nuts, or a diabetes diet designed in accordance with current diabetes dietary guidelines during two consecutive 3-month periods...
2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/26871396/prevalence-of-metabolic-syndrome-in-patients-undergoing-total-joint-arthroplasty-and-relevance-of-biomarkers
#4
Jennifer L Saluk, Andrew L Banos, William L Hopkinson, Harold L Rees, Daneyal Syed, Debra Hoppensteadt, Schuharazad Abro, Omer Iqbal, Jawed Fareed
BACKGROUND: Metabolic syndrome (MetS) is a collection of clinical conditions, including central obesity, hypertension, glucose intolerance and dyslipidemia. The long-term inflammatory and metabolic dysfunction associated with MetS may contribute to osteoarthritic processes leading up to total joint arthroplasty (TJA) . The purpose of this study was to investigate levels of metabolic biomarkers and the prevalence of MetS in patients undergoing TJA. METHODS: Under IRB approval, citrated plasma samples were collected from 41 patients undergoing total hip and knee arthroplasty (THA/TKA) pre-operatively and day 1 post- operatively...
February 12, 2016: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/26850040/feasibility-outcomes-of-a-presurgical-randomized-controlled-trial-exploring-the-impact-of-caloric-restriction-and-increased-physical-activity-versus-a-wait-list-control-on-tumor-characteristics-and-circulating-biomarkers-in-men-electing-prostatectomy-for-prostate
#5
RANDOMIZED CONTROLLED TRIAL
Wendy Demark-Wahnefried, Jeffery W Nix, Gary R Hunter, Soroush Rais-Bahrami, Renee A Desmond, Balu Chacko, Casey D Morrow, Maria Azrad, Andrew D Frugé, Yuko Tsuruta, Travis Ptacek, Scott A Tully, Roanne Segal, William E Grizzle
BACKGROUND: Obesity is associated with tumor aggressiveness and disease-specific mortality for more than 15 defined malignancies, including prostate cancer. Preclinical studies suggest that weight loss from caloric restriction and increased physical activity may suppress hormonal, energy-sensing, and inflammatory factors that drive neoplastic progression; however, exact mechanisms are yet to be determined, and experiments in humans are limited. METHODS: We conducted a randomized controlled trial among 40 overweight or obese, newly-diagnosed prostate cancer patients who elected prostatectomy to explore feasibility of a presurgical weight loss intervention that promoted a weight loss of roughly one kg...
February 5, 2016: BMC Cancer
https://www.readbyqxmd.com/read/26792047/metformin-for-lithium-induced-weight-gain-a-case-report
#6
Samir Kumar Praharaj
Lithium is the first line treatment for maintenance treatment of bipolar disorder. Among the long term adverse effects, weight gain is likely to affect a subset of patients. There is no specific guideline for the treatment of lithium-induced weight gain. We report a young male with bipolar disorder who had significant weight gain with lithium (25 kg), which responded to metformin treatment at 500 mg twice daily. The proposed mechanism of weight lowering effect of metformin includes changes in hypothalamic physiology, including leptin and insulin sensitivity, as well as circadian rhythm changes affecting food intake, regulation of fat oxidation and storage in liver, skeletal muscle, and adipose tissue...
February 29, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26586275/the-evidence-for-saturated-fat-and-for-sugar-related-to-coronary-heart-disease
#7
REVIEW
James J DiNicolantonio, Sean C Lucan, James H O'Keefe
Dietary guidelines continue to recommend restricting intake of saturated fats. This recommendation follows largely from the observation that saturated fats can raise levels of total serum cholesterol (TC), thereby putatively increasing the risk of atherosclerotic coronary heart disease (CHD). However, TC is only modestly associated with CHD, and more important than the total level of cholesterol in the blood may be the number and size of low-density lipoprotein (LDL) particles that contain it. As for saturated fats, these fats are a diverse class of compounds; different fats may have different effects on LDL and on broader CHD risk based on the specific saturated fatty acids (SFAs) they contain...
March 2016: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/26131838/a-prospective-follow-up-of-adipocytokines-in-cohort-patients-with-gout-association-with-metabolic-syndrome-but-not-with-clinical-inflammatory-findings-strobe-compliant-article
#8
Sergio García-Méndez, Carolina Bustos Rivera-Bahena, José Luis Montiel-Hernández, Daniel Xibillé-Friedmann, Everardo Álvarez-Hernández, Ingris Peláez-Ballestas, Rubén Burgos-Vargas, Janitzia Vázquez-Mellado
The aim of this study was to determine the levels of leptin (Lep) and adiponectin (AdipoQ) in patients with gout and its relationship with joint inflammatory data and/or with metabolic syndrome (MetS) variables, during 1 year follow-up.Forty-one patients (40 males) with gout diagnosis, attending for the first time to a rheumatology department, were included. Evaluations were performed baseline, at 6 and 12 months. Variables included the following: demographic, clinical and laboratory data related to gout and associated diseases...
July 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26116691/effects-of-exercise-training-on-cardiorespiratory-fitness-and-biomarkers-of-cardiometabolic-health-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#9
REVIEW
Xiaochen Lin, Xi Zhang, Jianjun Guo, Christian K Roberts, Steve McKenzie, Wen-Chih Wu, Simin Liu, Yiqing Song
BACKGROUND: Guidelines recommend exercise for cardiovascular health, although evidence from trials linking exercise to cardiovascular health through intermediate biomarkers remains inconsistent. We performed a meta-analysis of randomized controlled trials to quantify the impact of exercise on cardiorespiratory fitness and a variety of conventional and novel cardiometabolic biomarkers in adults without cardiovascular disease. METHODS AND RESULTS: Two researchers selected 160 randomized controlled trials (7487 participants) based on literature searches of Medline, Embase, and Cochrane Central (January 1965 to March 2014)...
July 2015: Journal of the American Heart Association
https://www.readbyqxmd.com/read/25978118/association-of-adipokines-and-inflammatory-markers-with-lipid-control-in-type-2-diabetes
#10
Agnieszka Kapłon-Cieślicka, Marek Postuła, Marek Rosiak, Michał Peller, Agnieszka Kondracka, Agnieszka Serafin, Ewa Trzepla, Grzegorz Opolski, Krzysztof J Filipiak
INTRODUCTION: Data regarding the effect of certain adipokines on lipid metabolism are equivocal. OBJECTIVES: The aim of this study was to evaluate the association of lipid control with adipokines and inflammatory markers in patients with type 2 diabetes. PATIENTS AND METHODS: The analysis included 195 patients with type 2 diabetes. The achievement of treatment targets in terms of total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides was assessed in accordance with the current guidelines...
2015: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/25450822/circulatory-adipocytokines-and-lipid-profile-variations-in-type-2-diabetic-subjects-desirable-side-effects-of-antidiabetic-drugs
#11
Abhijit A Ghadge, Shubhangi M Harke, Suresh P Khadke, Arundhati G Diwan, Madhu Pankaj, Omkar P Kulkarni, Prabhakar K Ranjekar, Aniket A Kuvalekar
AIM: Inspite of availability of a variety of drugs to treat type 2 diabetes, little is known about their effects on other systems. Normalization of glucose metabolism by these drugs may consequently affect the secretory function in adipocytes. Secretory adipocytokines like adiponectin and leptin are emerging as novel therapeutic targets for type 2 diabetes mellitus (T2DM). The present study was undertaken to analyze the effects of commonly used Oral Hypoglycemic Agents (OHAs) alone, or in combination with other drugs and/or insulin on circulatory adiponectin and leptin levels, lipid profile, and blood pressure in diabetic subjects...
October 2014: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/25404857/acceleration-training-for-managing-nonalcoholic-fatty-liver-disease-a-pilot-study
#12
Sechang Oh, Takashi Shida, Akemi Sawai, Tsuyoshi Maruyama, Kiyoshi Eguchi, Tomonori Isobe, Yoshikazu Okamoto, Noriko Someya, Kiyoji Tanaka, Emi Arai, Akiko Tozawa, Junichi Shoda
BACKGROUND: While aerobic training is generally recommended as therapeutic exercise in guidelines, the effectiveness of resistance training has recently been reported in the management of nonalcoholic fatty liver disease (NAFLD). Acceleration training (AT) is a new training method that provides a physical stimulation effect on skeletal muscles by increasing gravitational acceleration with vibration. AT has recently been indicated as a component of medicine. In this study, we evaluated the effectiveness of AT in the management of NAFLD in obese subjects...
2014: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/25346913/the-intake-of-fiber-mesocarp-passionfruit-passiflora-edulis-lowers-levels-of-triglyceride-and-cholesterol-decreasing-principally-insulin-and-leptin
#13
E M Corrêa, L Medina, J Barros-Monteiro, N O Valle, R Sales, A Magalães, F C A Souza, T B Carvalho, J R Lemos, E F Lira, E S Lima, D M L Galeno, L Morales, C Ortiz, R P Carvalho
BACKGROUND: Diabetes mellitus (DM) is a major risk factor for coronary artery disease, renal failure, retinopathy, and neuropathy. Over the last years, there has been an increasing demand in folk medicine for natural sources that could help in the treatment of chronic diseases, including diabetes. The rind of passion fruit (Passiflora edulis f. Flavicarpa) is traditionally used as a functional food due to its high concentration of soluble and insoluble fiber. OBJECTIVE: The aim of this study was to determine the effect of high-fiber diet albedo of passion fruit on the metabolic and biochemical profile in diabetic rats induced by alloxan (2%)...
2014: Journal of Aging Research & Clinical Practice
https://www.readbyqxmd.com/read/25238978/associations-between-time-spent-sitting-and-cancer-related-biomarkers-in-postmenopausal-women-an-exploration-of-effect-modifiers
#14
Raheem J Paxton, Su Yon Jung, Mara Z Vitolins, Jenifer Fenton, Electra Paskett, Michael Pollak, Jennifer Hays-Grudo, Stephen D Hursting, Shine Chang
PURPOSE: Despite evidence that prolonged periods of sitting may influence biological mediators of cancer development, few studies have considered these relationships in a cancer-specific context. METHODS: This cross-sectional study included 755 postmenopausal women enrolled in an ancillary study of the Women's Health Initiative. Plasma levels of Insulin-like growth factor-I (IGF-I), IGF-binding protein-3, leptin, insulin, C-peptide, C-reactive protein (CRP), and Interleukin (IL)-6 were measured...
November 2014: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/24896237/identification-of-those-most-likely-to-benefit-from-a-low-glycaemic-index-dietary-intervention-in-pregnancy
#15
RANDOMIZED CONTROLLED TRIAL
Jennifer M Walsh, Rhona M Mahony, Gillian Canty, Michael E Foley, Fionnuala M McAuliffe
The present study is a secondary analysis of the ROLO study, a randomised control trial of a low-glycaemic index (GI) diet in pregnancy to prevent the recurrence of fetal macrosomia. The objectives of the present study were to identify which women are most likely to respond to a low-GI dietary intervention in pregnancy with respect to three outcome measures: birth weight; maternal glucose intolerance; gestational weight gain (GWG). In early pregnancy, 372 women had their mid-upper arm circumference recorded and BMI calculated...
August 28, 2014: British Journal of Nutrition
https://www.readbyqxmd.com/read/24797089/molecular-dynamics-dynamic-site-mapping-and-highthroughput-virtual-screening-on-leptin-and-the-ob-receptor-as-anti-obesity-target
#16
Marco Tutone, Licia Pantano, Antonino Lauria, Anna Maria Almerico
Body weight control is a mechanism finely regulated by several hormonal, metabolic, and nervous pathways. The leptin receptor (Ob-R) is crucial for energy homeostasis and regulation of food uptake. Leptin is a 16 kDa hormone that is mainly secreted by fat cells into the bloodstream, and under normal circumstances, circulating levels are proportionate to the fat body mass. Sensing of elevated leptin levels by the hypothalamic neurocircutry activates a negative feedback loop resulting in reduced food intake and increased energy expenditure...
May 2014: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/24715415/obstetric-and-metabolic-implications-of-excessive-gestational-weight-gain-in-pregnancy
#17
COMPARATIVE STUDY
Jennifer M Walsh, Ciara A McGowan, Rhona M Mahony, Michael E Foley, Fionnuala M McAuliffe
OBJECTIVE: To compare maternal characteristics, obstetric outcomes and insulin resistance in a cohort of women subdivided into those who did and those who did not exceed the Institute of Medicine (IOM) gestational weight gain guidelines. METHODS: This is a prospective study of 621 women without diabetes. Concentrations of glucose, insulin and leptin were measured in early pregnancy and at 28 weeks. Ultrasound at 34 weeks assessed fetal anthropometry including abdominal wall width (AAW)...
July 2014: Obesity
https://www.readbyqxmd.com/read/24381180/postmenopausal-hypertension-role-of-the-sympathetic-nervous-system-in-an-animal-model
#18
Rodrigo O Maranon, Roberta Lima, Mohammed Mathbout, Jussara M do Carmo, John E Hall, Richard J Roman, Jane F Reckelhoff
In postmenopausal women the mechanisms responsible for hypertension have not been completely elucidated, and there are no gender-specific guidelines for women despite studies showing that blood pressure is not as well controlled to goal in women as in men. In the present study we tested the hypotheses that the sympathetic nervous system and the renal sympathetic nerves contribute to hypertension in aging female rats, that sympathetic activation may be mediated by the melanocortin 3/4 receptor (MC3/4R), and that MC3/4R activation may be due to increases in leptin...
February 15, 2014: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/24377454/effects-of-pistachio-nuts-on-body-composition-metabolic-inflammatory-and-oxidative-stress-parameters-in-asian-indians-with-metabolic-syndrome-a-24-wk-randomized-control-trial
#19
RANDOMIZED CONTROLLED TRIAL
Seema Gulati, Anoop Misra, Ravindra Mohan Pandey, Surya Prakash Bhatt, Shelza Saluja
OBJECTIVE: The aim of this study was to evaluate the effects of pistachio nuts as an adjunct to diet and exercise on body composition, metabolic, inflammatory, and oxidative stress parameters in Asian Indians with metabolic syndrome. METHODS: In this 24-wk randomized control trial, 60 individuals with the metabolic syndrome were randomized to either pistachio (intervention group) or control group (diet as per weight and physical activity profile, modulated according to dietary guidelines for Asian Indians) after 3 wk of a diet and exercise run in...
February 2014: Nutrition
https://www.readbyqxmd.com/read/24310634/obstructive-sleep-apnea-and-asthma
#20
REVIEW
Cristina Salles, Regina Terse-Ramos, Adelmir Souza-Machado, Álvaro A Cruz
Symptoms of sleep-disordered breathing, especially obstructive sleep apnea syndrome (OSAS), are common in asthma patients and have been associated with asthma severity. It is known that asthma symptoms tend to be more severe at night and that asthma-related deaths are most likely to occur during the night or early morning. Nocturnal symptoms occur in 60-74% of asthma patients and are markers of inadequate control of the disease. Various pathophysiological mechanisms are related to the worsening of asthma symptoms, OSAS being one of the most important factors...
September 2013: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
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