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https://www.readbyqxmd.com/read/29075831/repeatability-of-tumour-hypoxia-imaging-using-18-f-ef5-pet-ct-in-head-and-neck-cancer
#1
Antti Silvoniemi, Sami Suilamo, Timo Laitinen, Sarita Forsback, Eliisa Löyttyniemi, Samuli Vaittinen, Virva Saunavaara, Olof Solin, Tove J Grönroos, Heikki Minn
PURPOSE: Hypoxia contributes to radiotherapy resistance and more aggressive behaviour of several types of cancer. This study was designed to evaluate the repeatability of intratumour uptake of the hypoxia tracer [(18)F]EF5 in paired PET/CT scans. METHODS: Ten patients with newly diagnosed head and neck cancer (HNC) received three static PET/CT scans before chemoradiotherapy: two with [(18)F]EF5 a median of 7 days apart and one with [(18)F]FDG. Metabolically active primary tumour volumes were defined in [(18)F]FDG images and transferred to co-registered [(18)F]EF5 images for repeatability analysis...
October 26, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29057432/strategy-and-early-results-of-treatment-of-advanced-cervical-cancer-patients-with-synchronous-cancers-observed-in-pet-ct-imaging
#2
Michał Płachta, Witold Cholewiński, Ewa Burchardt, Paulina Cegła, Bartosz Urbański, Żaneta Wareńczak-Florczak, Andrzej Roszak
OBJECTIVES: The aim of this study was to present strategy and early results of treatment of advanced cervical cancer patients with synchronous cancers observed in PET-CT imaging, treated at the Greater Poland Cancer Center. MATERIAL AND METHODS: The study included a group of 200 patients with diagnosed stage IIB-IIIB cervical cancer who received PET-CT for the purpose of radiotherapy treatment planning. RESULTS: Among our study group, four patients (2%) were found to have a synchronous cancer...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/29029767/pet-ct-and-pet-mri-in-head-and-neck-malignancy
#3
REVIEW
T A Szyszko, G J R Cook
Combined 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET)/computed tomography (CT) has an established role in the staging of difficult cases of head and neck (HN) squamous cell carcinoma (SCC), looking for an unknown primary, assessing response post-chemotherapy at 3-6 months, and differentiating relapse from treatment effects in patients suspected to have tumour recurrence. The PET NECK trial, comparing PET/CT surveillance versus neck dissection in advanced head and neck cancer showed survival was similar among patients who underwent PET/CT-guided surveillance and those who underwent planned neck dissection, but surveillance was more cost-effective...
October 10, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28951007/-18-f-fdg-pet-image-biomarkers-improve-prediction-of-late-radiation-induced-xerostomia
#4
Lisanne V van Dijk, Walter Noordzij, Charlotte L Brouwer, Ronald Boellaard, Johannes G M Burgerhof, Johannes A Langendijk, Nanna M Sijtsema, Roel J H M Steenbakkers
BACKGROUND AND PURPOSE: Current prediction of radiation-induced xerostomia 12months after radiotherapy (Xer12m) is based on mean parotid gland dose and baseline xerostomia (Xerbaseline) scores. The hypothesis of this study was that prediction of Xer12m is improved with patient-specific characteristics extracted from (18)F-FDG PET images, quantified in PET image biomarkers (PET-IBMs). PATIENTS AND METHODS: Intensity and textural PET-IBMs of the parotid gland were collected from pre-treatment (18)F-FDG PET images of 161 head and neck cancer patients...
September 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28882674/liposome-accumulation-in-irradiated-tumors-display-important-tumor-and-dose-dependent-differences
#5
Anders Elias Hansen, Frederikke Petrine Fliedner, Jonas Rosager Henriksen, Jesper Tranekjær Jørgensen, Andreas Ettrup Clemmensen, Betina Børresen, Dennis Ringkjøbing Elema, Andreas Kjær, Thomas Lars Andresen
Radiation therapy may affect several important parameters in the tumor microenvironment and thereby influence the accumulation of liposomes by the enhanced permeability and retention (EPR)-effect. Here we investigate the effect of single dose radiation therapy on liposome tumor accumulation by PET/CT imaging using radiolabeled liposomes. Head and neck cancer xenografts (FaDu) and syngenic colorectal (CT26) cancer models were investigated. Radiotherapy displayed opposite effects in the two models. FaDu tumors displayed increased mean accumulation of liposomes for radiation doses up to 10 Gy, whereas CT26 tumors displayed a tendency for decreased accumulation...
September 4, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28881249/cost-effectiveness-analysis-of-pet-ct-guided-management-for-locally-advanced-head-and-neck-cancer
#6
RANDOMIZED CONTROLLED TRIAL
A F Smith, P S Hall, C T Hulme, J A Dunn, C C McConkey, J K Rahman, C McCabe, H Mehanna
BACKGROUND: A recent large United Kingdom (UK) clinical trial demonstrated that positron-emission tomography-computed tomography (PET-CT)-guided administration of neck dissection (ND) in patients with advanced head and neck cancer after primary chemo-radiotherapy treatment produces similar survival outcomes to planned ND (standard care) and is cost-effective over a short-term horizon. Further assessment of long-term outcomes is required to inform a robust adoption decision. Here we present results of a lifetime cost-effectiveness analysis of PET-CT-guided management from a UK secondary care perspective...
November 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28843726/residual-tumour-hypoxia-in-head-and-neck-cancer-patients-undergoing-primary-radiochemotherapy-final-results-of-a-prospective-trial-on-repeat-fmiso-pet-imaging
#7
Steffen Löck, Rosalind Perrin, Annekatrin Seidlitz, Anna Bandurska-Luque, Sebastian Zschaeck, Klaus Zöphel, Mechthild Krause, Jörg Steinbach, Jörg Kotzerke, Daniel Zips, Esther G C Troost, Michael Baumann
BACKGROUND: Hypoxia is a well recognised parameter of tumour resistance to radiotherapy, a number of anticancer drugs and potentially immunotherapy. In a previously published exploration cohort of 25 head and neck squamous cell carcinoma (HNSCC) patients on [(18)F]fluoromisonidazole positron emission tomography (FMISO-PET) we identified residual tumour hypoxia during radiochemotherapy, not before start of treatment, as the driving mechanism of hypoxia-mediated therapy resistance. Several quantitative FMISO-PET parameters were identified as potential prognostic biomarkers...
September 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28833829/long-term-outcome-of-18-f-fluorodeoxyglucose-positron-emission-tomography-guided-dose-painting-for-head-and-neck-cancer-matched-case-control-study
#8
Dieter Berwouts, Indira Madani, Frédéric Duprez, AnaMaria Luiza Olteanu, Tom Vercauteren, Tom Boterberg, Philippe Deron, Katrien Bonte, Wouter Huvenne, Wilfried De Neve, Ingeborg Goethals
BACKGROUND: The purpose of this study was to report the long-term outcome of (18) F-fluorodeoxyglucose-positron emission tomography ((18) F-FDG-PET)-guided dose painting for head and neck cancer in comparison to conventional intensity-modulated radiotherapy (IMRT) in a matched case-control study. METHODS: Seventy-two patients with nonmetastatic head and neck cancer treated with dose painting were compared with 72 control patients matched on tumor site and T classification...
August 21, 2017: Head & Neck
https://www.readbyqxmd.com/read/28826293/analysis-of-ct-verified-loco-regional-recurrences-after-definitive-imrt-for-hnscc-using-site-of-origin-estimation-methods
#9
Ruta Zukauskaite, Christian R Hansen, Carsten Brink, Jørgen Johansen, Jon T Asmussen, Cai Grau, Jens Overgaard, Jesper G Eriksen
INTRODUCTION: A significant part of patients with head and neck squamous cell carcinoma (HNSCC) develop recurrent disease after curative radiotherapy. We aimed to analyze loco-regional recurrence pattern by identifying possible points of recurrence origin by three different methods in relation to treatment volumes. MATERIAL AND METHODS: A total of 455 patients completed IMRT-based treatment for HNSCC from 2006 to 2012. A total of 159 patients had remaining cancer after IMRT, developed loco-regional recurrence or distant disease during follow-up...
November 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28815841/response-assessment-after-induction-chemotherapy-for-head-and-neck-squamous-cell-carcinoma-from-physical-examination-to-modern-imaging-techniques-and-beyond
#10
REVIEW
Remco de Bree, Gregory T Wolf, Bart de Keizer, Iain J Nixon, Dana M Hartl, Arlene A Forastiere, Missak Haigentz, Alessandra Rinaldo, Juan P Rodrigo, Nabil F Saba, Carlos Suárez, Jan B Vermorken, Alfio Ferlito
Significant correlations between the response to induction chemotherapy and success of subsequent radiotherapy have been reported and suggest that the response to induction chemotherapy is able to predict a response to radiotherapy. Therefore, induction chemotherapy may be used to tailor the treatment plan to the individual patient with head and neck cancer: following the planned subsequent (chemo)radiation schedule, planning a radiation dose boost, or reassessing the modality of treatment (eg, upfront surgery)...
November 2017: Head & Neck
https://www.readbyqxmd.com/read/28809864/predicting-response-to-radical-chemo-radiotherapy-with-circulating-hpv-dna-in-locally-advanced-head-and-neck-squamous-carcinoma
#11
Jen Y Lee, Isaac Garcia-Murillas, Rosalind J Cutts, David Gonzalez De Castro, Lorna Grove, Tara Hurley, Fuqiang Wang, Christopher Nutting, Katie Newbold, Kevin Harrington, Nicholas Turner, Shreerang Bhide
BACKGROUND: Following chemo-radiotherapy (CCRT) for human papilloma virus positive (HPV+) locally advanced head and neck cancer, patients frequently undergo unnecessary neck dissection (ND) and/or repeated biopsies for abnormal PET-CT, which causes significant morbidity. We assessed the role of circulating HPV DNA in identifying 'true' residual disease. METHODS: We prospectively recruited test (n=55) and validation (n=33) cohorts. HPV status was confirmed by E7 RT-PCR...
September 5, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28771540/18f-fdg-pet-ct-for-the-detection-of-disease-in-patients-with-head-and-neck-cancer-treated-with-radiotherapy
#12
Nils Helsen, Dessie Roothans, Bert Van Den Heuvel, Tim Van den Wyngaert, Danielle Van den Weyngaert, Laurens Carp, Sigrid Stroobants
OBJECTIVE: The aim of this study is to evaluate the diagnostic performance of FDG-PET/CT for the detection of residual disease after (chemo)radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC) and to evaluate the prognostic value of the FDG-PET/CT findings. METHODS: Patients with HNSCC who underwent FDG-PET/CT after (chemo)radiotherapy were studied retrospectively. RESULTS: 104 FDG-PET/CT-scans were performed at a median of 13...
2017: PloS One
https://www.readbyqxmd.com/read/28745907/role-of-fdg-pet-ct-scan-in-head-and-neck-cancer-patients
#13
Mehrdad Bakhshayesh Karam, Abtin Doroudinia, Ali Safavi Nainee, Fatemeh Kaghazchi, Abbas Yousefi Koma, Payam Mehrian, Farahnaz Agha Hossein
INTRODUCTION: PET/CT scan has an emerging role in head and neck oncology with a few well-established indications, including: detection of unknown primary tumor site, tumor staging, radiotherapy planning, treatment response assessment and detection of recurrent disease. The purpose of this study is reporting PET/CT findings in head and neck cancer patients to emphasize its role in head and neck oncology. MATERIALS AND METHODS: In a retrospective study, we reviewed our PET/CT database and found 94 patients with primary head and neck cancer...
July 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28697190/-18-f-fdg-pet-ct-and-histology-for-diagnosing-recurrent-remnant-tumors-in-head-and-neck-cancer-patients-treated-with-radiotherapy
#14
Eun Ji Han, Joo Hyun O, Ie Ryung Yoo, Yeon Sil Kim, Min Sik Kim, Jin Hyoung Kang, Woo Hee Choi
OBJECTIVE: The aim of this study was to assess the diagnostic performance of fluorine-18-fluoro-2-deoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) for locoregional recurrent/residual tumor in patients with head and neck cancer (HNC) who underwent previous radiotherapy (RT). SUBJECTS AND METHODS: (18)F-FDG PET/CT images from patients with HNC who previously underwent RT were retrospectively reviewed. Only cases with histological confirmation within 4 weeks of PET/CT imaging were included...
May 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28693449/multiparametric-magnetic-resonance-imaging-in-mucosal-primary-head-and-neck-cancer-a-prospective-imaging-biomarker-study
#15
Christopher N Rumley, Mark T Lee, Lois Holloway, Robba Rai, Myo Min, Dion Forstner, Allan Fowler, Gary Liney
BACKGROUND: Radical radiotherapy, with or without concomitant chemotherapy forms the mainstay of organ preservation approaches in mucosal primary head and neck cancer. Despite technical advances in cancer imaging and radiotherapy administration, a significant proportion of patients fail to achieve a complete response to treatment. For those patients who do achieve a complete response, acute and late toxicities remain a cause of morbidity. A critical need therefore exists for imaging biomarkers which are capable of informing patient selection for both treatment intensification and de-escalation strategies...
July 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28669443/i-125-brachytherapy-guided-by-individual-three-dimensional-printed-plates-for-recurrent-ameloblastoma-of-the-skull-base
#16
J-Y Liu, Q-W Man, Y-Q Ma, B Liu
Ameloblastoma is one of the most common benign odontogenic tumours of the mandible and the maxilla. Wide excision of the tumour is the first choice for treatment (except for unicystic ones). Patients with invaded margins or unresectable lesions may require radiotherapy. Today, permanent implantation of I(125) seeds is widely used in the treatment of cancer of the head and neck. We report a case of recurrent ameloblastoma of the base of the skull that was treated with I(125) brachytherapy. The outcome has been encouraging, with total disappearance of the tumour on positron emission tomography 18 months later...
June 29, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28658110/the-clinical-outcome-correlations-between-radiation-dose-and-pretreatment-metabolic-tumor-volume-for-radiotherapy-in-head-and-neck-cancer-a-retrospective-analysis
#17
Shih-Neng Yang, Yu-Rou Chiou, Geoffrey G Zhang, Kuei-Ting Chou, Tzung-Chi Huang
This study was to investigate the clinical outcomes between radiation dose and pretreatment metabolic tumor volume (MTV) in patients with head and neck cancer treated with definitive chemoradiotherapy.Thirty-four patients received pretreatment F-fluorodeoxyglucose (F-FDG) positron emission tomography-computed tomography (PET/CT) were recruited for this study. The CT-based volume (gross tumor volume of the primary [GTVp]) and 4 types of MTVs were measured on the basis of either a maximal standardized uptake value (SUVmax) of 2...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28612199/mri-guided-radiotherapy-for-head-and-neck-cancer-initial-clinical-experience
#18
A M Chen, S Hsu, J Lamb, Y Yang, N Agazaryan, M L Steinberg, D A Low, M Cao
PURPOSE: To report a single-institutional experience with the use of magnetic resonance imaging (MRI)-guided radiotherapy for cancers of the head and neck. MATERIALS AND METHODS: Between October 2014 and October 2016, 18 patients with newly diagnosed cancers of the head and neck were prospectively enrolled on an institutional registry trial investigating the feasibility and efficacy of external-beam radiotherapy delivered using on-board MRI. All patients had biopsy-proven evidence of malignancy, measurable disease, and the ability to provide consent...
June 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28555505/comparison-of-dose-distribution-for-head-and-neck-cancer-patients-with-and-without-dose-painting-escalation-during-radiotherapy-realized-with-tomotherapy-unit
#19
COMPARATIVE STUDY
Malgorzata Skorska, Tomasz Piotrowski, Adam Ryczkowski
OBJECTIVE: To determine and quantify the percentage dose increase to organs at risk (OARs) with multiple-level dose painting (DP) for patients with head and neck cancer in comparison with standard regimen. METHODS: 12 patients who had undergone fluorine-18 fludeoxyglucose ((18)F-FDG) positron emission tomography (PET)/CT scan were retrospectively enrolled. Two treatment plans-one using DP escalation and one without-were optimized for each patient base on PET/CT data...
July 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28540535/prognostic-value-of-maximum-standardized-uptake-value-measured-by-pretreatment-18f-fdg-pet-ct-in-locally-advanced-head-and-neck-squamous-cell-carcinoma
#20
J Cacicedo, I Fernandez, O Del Hoyo, A Navarro, A Gomez-Iturriaga, J Ignacio Pijoan, L Martinez-Indart, J Escudero, J Gomez-Suarez, R Ortiz de Zarate, J Fernando Perez, P Bilbao, D Rades
PURPOSE/OBJECTIVES: To evaluate the prognostic impact of maximum standardized uptake value (SUVmax) in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) undergoing pretreatment [F-18] fluoro-D-glucose-positron emission tomography/computed tomography (FDG PET/CT) imaging. MATERIALS/METHODS: Fifty-eight patients undergoing FDG PET/CT before radical treatment with definitive radiotherapy (±concomitant chemotherapy) or surgery + postoperative (chemo)radiation were analyzed...
November 2017: Clinical & Translational Oncology
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