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https://www.readbyqxmd.com/read/28612199/mri-guided-radiotherapy-for-head-and-neck-cancer-initial-clinical-experience
#1
A M Chen, S Hsu, J Lamb, Y Yang, N Agazaryan, M L Steinberg, D A Low, M Cao
PURPOSE: To report a single-institutional experience with the use of magnetic resonance imaging (MRI)-guided radiotherapy for cancers of the head and neck. MATERIALS AND METHODS: Between October 2014 and October 2016, 18 patients with newly diagnosed cancers of the head and neck were prospectively enrolled on an institutional registry trial investigating the feasibility and efficacy of external-beam radiotherapy delivered using on-board MRI. All patients had biopsy-proven evidence of malignancy, measurable disease, and the ability to provide consent...
June 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28555505/comparison-of-dose-distribution-for-head-and-neck-cancer-patients-with-and-without-dose-painting-escalation-during-radiotherapy-realized-with-tomotherapy-unit
#2
Malgorzata Skorska, Tomasz Piotrowski, Adam Ryczkowski
OBJECTIVE: To determine and quantify the percentage dose increase to organs at risk (OARs) with multiple-level dose painting (DP) for patients with head and neck cancer in comparison with standard regimen. METHODS: 12 patients who had undergone fluorine-18 fludeoxyglucose ((18)F-FDG) positron emission tomography (PET)/CT scan were retrospectively enrolled. Two treatment plans-one using DP escalation and one without-were optimized for each patient base on PET/CT data...
June 23, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28540535/prognostic-value-of-maximum-standardized-uptake-value-measured-by-pretreatment-18f-fdg-pet-ct-in-locally-advanced-head-and-neck-squamous-cell-carcinoma
#3
J Cacicedo, I Fernandez, O Del Hoyo, A Navarro, A Gomez-Iturriaga, J Ignacio Pijoan, L Martinez-Indart, J Escudero, J Gomez-Suarez, R Ortiz de Zarate, J Fernando Perez, P Bilbao, D Rades
PURPOSE/OBJECTIVES: To evaluate the prognostic impact of maximum standardized uptake value (SUVmax) in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) undergoing pretreatment [F-18] fluoro-D-glucose-positron emission tomography/computed tomography (FDG PET/CT) imaging. MATERIALS/METHODS: Fifty-eight patients undergoing FDG PET/CT before radical treatment with definitive radiotherapy (±concomitant chemotherapy) or surgery + postoperative (chemo)radiation were analyzed...
May 24, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28539202/detection-of-residual-head-and-neck-squamous-cell-carcinoma-after-chemo-radiotherapy-a-pilot-study-assessing-the-value-of-diffusion-weighted-magnetic-resonance-imaging-as-an-adjunct-to-pet-ct-using-18-f-fdg
#4
Daniel P Noij, Viresh A Jagesar, Pim de Graaf, Marcus C de Jong, Otto S Hoekstra, Remco de Bree, Jonas A Castelijns
OBJECTIVE: Diagnosing residual malignancy after (chemo)radiotherapy presents a diagnostic challenge because of overlapping symptoms and imaging characteristics. We assessed the added diagnostic value of diffusion-weighted imaging (DWI) to positron emission tomography combined with computed tomography (PET-CT) in patients with head and neck squamous cell carcinoma (HNSCC) with residual fluorodeoxyglucose ((18)F-FDG) uptake at the primary tumor site 3 months after (chemo)radiotherapy. STUDY DESIGN: For this retrospective study from January 2010 to June 2012, 22 cases (median patient age of 61 years; range 41-77 years) were included for analysis...
May 3, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28451717/-pet-ct-in-head-and-neck-cancer
#5
T Send, B Kreppel, F C Gaertner, R A Bundschuh, H Strunk, F Bootz, M Essler
The importance of (18)F-fluorodesoxyglucose positron-emission tomography (FDG-PET) for the diagnosis of malignant disease is increasing. On one hand, this is due to the high sensitivity of this method, on the other, because the entire body can be examined. FDG-PET can be particularly advantageous for the diagnosis of head and neck tumors, where tumor staging is an important prognostic parameter and essentially determines the therapeutic regimen. This article presents the different possibilities for combined evaluation with PET and computed tomography (CT) for the diagnosis of patients with head and neck cancer...
April 27, 2017: HNO
https://www.readbyqxmd.com/read/28390531/pet-mr-imaging-in-head-and-neck
#6
REVIEW
Yueh Z Lee, Joana Ramalho, Brice Kessler
Head and neck cancers are a diverse group of cancers with high morbidity and mortality within an area of complex anatomy. High-quality anatomic and functional imaging is essential for preoperative, chemotherapeutic, and radiotherapy planning. Early studies show that hybrid PET-MR imaging offers great potential for improving the imaging of head and neck cancers. Furthermore, advanced MR imaging techniques may also be incorporated to further enhance the diagnostic value of the combined modality.
May 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28370570/unknown-primary-head-and-neck-squamous-cell-carcinoma-in-the-era-of-fluorodeoxyglucose-positron-emission-tomography-ct-and-intensity-modulated-radiotherapy
#7
Mischa de Ridder, Martin Klop, Olga Hamming-Vrieze, JanPaul de Boer, Bas Jasperse, Laura Smit, Wouter Vogel, Michiel van den Brekel, Abrahim Al-Mamgani
BACKGROUND: The diagnosis and treatment of head and neck carcinoma of unknown primary (CUP) have changed with the introduction of fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT and intensity-modulated radiotherapy (IMRT), with potential implications for outcome. METHODS: We conducted a retrospective analysis of 80 patients with head and neck CUP who were PET-staged and treated with curative intention using IMRT between 2006 and 2016 in the Netherlands Cancer Institute...
March 28, 2017: Head & Neck
https://www.readbyqxmd.com/read/28296324/the-feasibility-of-atlas-based-automatic-segmentation-of-mri-for-h-n-radiotherapy-planning
#8
Kieran Wardman, Robin J D Prestwich, Mark J Gooding, Richard J Speight
Atlas-based autosegmentation is an established tool for segmenting structures for CT-planned head and neck radiotherapy. MRI is being increasingly integrated into the planning process. The aim of this study is to assess the feasibility of MRI-based, atlas-based autosegmentation for organs at risk (OAR) and lymph node levels, and to compare the segmentation accuracy with CT-based autosegmentation. Fourteen patients with locally advanced head and neck cancer in a prospective imaging study underwent a T1-weighted MRI and a PET-CT (with dedicated contrast-enhanced CT) in an immobilization mask...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28263422/correlation-between-fluorodeoxyglucose-hotspots-on-pretreatment-positron-emission-tomography-ct-and-preferential-sites-of-local-relapse-after-chemoradiotherapy-for-head-and-neck-squamous-cell-carcinoma
#9
Anne Chaput, Jérémie Calais, Philippe Robin, Sébastien Thureau, David Bourhis, Romain Modzelewski, Ulrike Schick, Pierre Vera, Pierre-Yves Salaün, Ronan Abgral
BACKGROUND: The potential benefits of (18) F-fluoro-2-deoxy-D-glucose-positron emission tomography/CT (FDG-PET/CT) imaging for radiotherapy (RT) treatment planning of head and neck squamous cell carcinoma (HNSCC) are increasingly being recognized. It has been suggested that intratumoral subvolumes with high FDG avidity ("hotspots") are potential targets for selected dose escalation. The purposes of this study were to demonstrate that pre-RT FDG-PET/CT can identify intratumoral sites at increased risk of local relapse after RT and to determine an optimal threshold to delineate smaller RT target volumes that would facilitate RT dose escalation without impaired tolerance...
March 6, 2017: Head & Neck
https://www.readbyqxmd.com/read/28249612/do-selective-radiation-dose-escalation-and-tumour-hypoxia-status-impact-the-loco-regional-tumour-control-after-radio-chemotherapy-of-head-neck-tumours-the-escalox-protocol
#10
Steffi U Pigorsch, Jan J Wilkens, Severin Kampfer, Victoria Kehl, Alexander Hapfelmeier, Christian Schläger, Henning Bier, Markus Schwaiger, Stephanie E Combs
BACKGROUND: Standard of care primary treatment of carcinoma of locally advanced squamous cell head and neck cancer (LAHNSCC) consists of platinum-based concomitant chemo-irradiation. Despite progress in the treatment of LAHNSCC using modern radiotherapy techniques the outcome remains still poor. Using IMRT with SIB the escalation of total dose to the GTV is possible with the aim to improve clinical outcome. This study tests the hypothesis if radiation dose escalation to the GTV improves 2-year-LRC and -OS after concomitant chemo-irradiation...
March 1, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28126329/head-and-neck-target-delineation-using-a-novel-pet-automatic-segmentation-algorithm
#11
B Berthon, M Evans, C Marshall, N Palaniappan, N Cole, V Jayaprakasam, T Rackley, E Spezi
PURPOSE: To evaluate the feasibility and impact of using a novel advanced PET auto-segmentation method in Head and Neck (H&N) radiotherapy treatment (RT) planning. METHODS: ATLAAS, Automatic decision Tree-based Learning Algorithm for Advanced Segmentation, previously developed and validated on pre-clinical data, was applied to (18)F-FDG-PET/CT scans of 20 H&N patients undergoing Intensity Modulated Radiation Therapy. Primary Gross Tumour Volumes (GTVs) manually delineated on CT/MRI scans (GTVpCT/MRI), together with ATLAAS-generated contours (GTVpATLAAS) were used to derive the RT planning GTV (GTVpfinal)...
February 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28048206/su-f-t-685-evaluation-of-tumor-hypoxic-fraction-using-serial-volumetric-imaging-during-radiation-therapy
#12
A Chvetsov
PURPOSE: To develop a tumor response model which could be uses to compute tumor hypoxic fraction using serial volumetric tumor imaging. This algorithm may be used for treatment response assessment and also for guidance of more expensive PET imaging of hypoxia. METHODS: Previously developed two-level cell population tumor response model was modified to include a third cell level describing hypoxic and necrotic cells. This third level was considered constant value during radiotherapy treatment; therefore, inclusion additional parameter did not compromise stability of model fitting to imaging data...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047089/th-cd-206-05-machine-learning-based-segmentation-of-organs-at-risks-for-head-and-neck-radiotherapy-planning
#13
B Ibragimov, F Pernus, P Strojan, L Xing
PURPOSE: Accurate and efficient delineation of tumor target and organs-at-risks is essential for the success of radiotherapy. In reality, despite of decades of intense research efforts, auto-segmentation has not yet become clinical practice. In this study, we present, for the first time, a deep learning-based classification algorithm for autonomous segmentation in head and neck (HaN) treatment planning. METHODS: Fifteen HN datasets of CT, MR and PET images with manual annotation of organs-at-risk (OARs) including spinal cord, brainstem, optic nerves, chiasm, eyes, mandible, tongue, parotid glands were collected and saved in a library of plans...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046431/we-ab-202-11-radiobiological-modeling-of-tumor-response-during-radiotherapy-based-on-pre-treatment-dynamic-pet-imaging-data
#14
M Crispin-Ortuzar, M Grkovski, B Beattie, N Lee, N Riaz, J Humm, J Jeong, A Fontanella, J Deasy
PURPOSE: To evaluate the ability of a multiscale radiobiological model of tumor response to predict mid-treatment hypoxia images, based on pretreatment imaging of perfusion and hypoxia with [18-F]FMISO dynamic PET and glucose metabolism with [18-F]FDG PET. METHODS: A mechanistic tumor control probability (TCP) radiobiological model describing the interplay between tumor cell proliferation and hypoxia (Jeong et al., PMB 2013) was extended to account for intra-tumor nutrient heterogeneity, dynamic cell migration due to nutrient gradients, and stromal cells...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28027517/-18-f-fdg-pet-ct-surveillance-for-the-detection-of-recurrence-in-patients-with-head-and-neck-cancer
#15
Shin-Ae Kim, Jong-Lyel Roh, Jae Seung Kim, Jeong Hyun Lee, Sang Hoon Lee, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Posttreatment detection of recurrence may lead to salvage treatment and prognostic prediction in patients with head and neck squamous cell carcinoma (HNSCC). We evaluated the diagnostic and prognostic values of (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) after definitive treatment of HNSCC. METHODS: This prospective study included 278 consecutive patients who underwent curative surgery (n = 143, 51...
February 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28008773/radiotherapy-response-evaluation-using-fdg-pet-ct-established-and-emerging-applications
#16
REVIEW
Helen Cliffe, Chirag Patel, Robin Prestwich, Andrew Scarsbrook
Radiation therapy is a common component of curative cancer treatment. However, there is a significant incidence of treatment failure. In these cases, salvage surgical options are sometimes appropriate. Accurate assessment of response and early recognition of treatment success or failure is therefore critical to guide treatment decisions and impacts on survival and the morbidity of treatment. Traditionally, treatment response has depended upon the anatomical measurement of disease. However, this may not correlate well with the presence of disease, especially after radiotherapy...
March 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28004135/nodal-parameters-of-fdg-pet-ct-performed-during-radiotherapy-for-locally-advanced-mucosal-primary-head-and-neck-squamous-cell-carcinoma-can-predict-treatment-outcomes-suvmean-and-response-rate-are-useful-imaging-biomarkers
#17
Peter Lin, Myo Min, Mark Lee, Lois Holloway, Dion Forstner, Victoria Bray, Allan Fowler
PURPOSE: To evaluate the prognostic utility of nodal metabolic parameters derived from FDG PET/CT performed before radiotherapy (prePET) and during the third week of radiotherapy (iPET) in patients with mucosal primary head and neck squamous cell carcinoma (MPHNSCC). METHODS: This analysis included 75 patients with newly diagnosed locally advanced node-positive MPHNSCC treated with radical radiotherapy and concurrent systemic therapy who underwent prePET and iPET: N1 11 patients, N2a 38, N2b 12, N2c 9, N3 5...
May 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27931839/overview-of-the-predictive-value-of-quantitative-18-fdg-pet-in-head-and-neck-cancer-treated-with-chemoradiotherapy
#18
REVIEW
J Castelli, B De Bari, A Depeursinge, A Simon, A Devillers, G Roman Jimenez, J Prior, M Ozsahin, R de Crevoisier, J Bourhis
18 F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) allows to quantify the metabolic activity of a tumor (glycolysis) and has become a reference tool in oncology for the staging, restaging, radiotherapy planning and monitoring response in many cancers. Quantitative analyses have been introduced in order to overcome some of the limits of the visual methods, allowing an easier and more objective comparison of the inter- and intra-patients variations. The aims of this review were to report available evidences on the clinical value of quantitative PET/CT parameters in HNC...
December 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27833757/a-prospective-multicentre-single-arm-clinical-trial-of-bevacizumab-for-patients-with-surgically-untreatable-symptomatic-brain-radiation-necrosis-%C3%A2
#19
Motomasa Furuse, Naosuke Nonoguchi, Toshihiko Kuroiwa, Susumu Miyamoto, Yoshiki Arakawa, Jun Shinoda, Kazuhiro Miwa, Toshihiko Iuchi, Koji Tsuboi, Kiyohiro Houkin, Shunsuke Terasaka, Yusuke Tabei, Hideo Nakamura, Motoo Nagane, Kazuhiko Sugiyama, Mizuhiko Terasaki, Tatsuya Abe, Yoshitaka Narita, Nobuhito Saito, Akitake Mukasa, Kuniaki Ogasawara, Takaaki Beppu, Toshihiro Kumabe, Tadashi Nariai, Naohiro Tsuyuguchi, Eiji Nakatani, Shoko Kurisu, Yoko Nakagawa, Shin-Ichi Miyatake
BACKGROUND: Brain radiation necrosis (BRN) can be a complication of radiotherapy for primary and secondary brain tumors, as well as head and neck tumors. Since vascular endothelial growth factor (VEGF) is also a vascular permeability factor in the brain, bevacizumab, a humanized antibody that inhibits VEGF, would be expected to reduce perilesional edema that often accompanies BRN. METHODS: Patients with surgically untreatable, symptomatic BRN refractory to conventional medical treatments (eg, corticosteroid, anticoagulants, or hyperbaric oxygen therapy) were enrolled...
December 2016: Neuro-oncology Practice
https://www.readbyqxmd.com/read/27707505/dose-painting-by-numbers-based-on-retrospectively-determined-recurrence-probabilities
#20
Eric Grönlund, Silvia Johansson, Anders Montelius, Anders Ahnesjö
BACKGROUND AND PURPOSE: The aim of this study is to derive "dose painting by numbers" prescriptions from retrospectively observed recurrence volumes in a patient group treated with conventional radiotherapy for head and neck squamous cell carcinoma. MATERIALS AND METHODS: The spatial relation between retrospectively observed recurrence volumes and pre-treatment standardized uptake values (SUV) from fluorodeoxyglucose positron emission tomography (FDG-PET) imaging was determined...
October 1, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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