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https://www.readbyqxmd.com/read/29764822/numb-chin-syndrome-an-ominous-sign-of-mandibular-metastasis
#1
Abdul Razak, Bee See Goh, Jothi Raamahlingam Rajaran, Abd Jabar Nazimi
A 51-year-old woman a known case of stage 2 breast carcinoma in 2006 and underwent left mastectomy performed in the same year presented with bilateral lower limb pain suggestive of spinal pathology, and left chin numbness, both of 2 weeks' duration. Examination revealed left mandibular hypoesthesia without any other sign or symptoms. Orthopantomogram was unremarkable apart from mild alveolar bone expansion at tooth 36 area, which was extracted 3 months earlier. Subsequently, a full-body positron emission tomography contrast enhanced computer tomography revealed hypermetabolic lesions of her axial (excluding skull) and appendicular skeleton...
May 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29761228/patterns-of-care-analysis-for-head-neck-cancer-of-unknown-primary-site-a-survey-inside-the-german-society-of-radiation-oncology-degro
#2
Jens Müller von der Grün, Dimitra Bon, Claus Rödel, Panagiotis Balermpas
BACKGROUND: Due to the absence of randomized trials, the optimal management for squamous cell cancer of unknown primary in the head and neck region (SCCHN CUP) remains controversial. Current strategies are based on retrospective studies, clinical experience, and institutional policies. METHODS: An anonymous questionnaire with a total of 24 questions was created and distributed by the use of an online version (Google Forms®, Google, Mountain View, CA, USA) as well as a printout version as equivalent option...
May 14, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29747873/assessment-of-image-quality-of-a-radiotherapy-specific-hardware-solution-for-pet-mri-in-head-and-neck-cancer-patients
#3
René M Winter, Sara Leibfarth, Holger Schmidt, Kerstin Zwirner, David Mönnich, Stefan Welz, Nina F Schwenzer, Christian la Fougère, Konstantin Nikolaou, Sergios Gatidis, Daniel Zips, Daniela Thorwarth
BACKGROUND AND PURPOSE: Functional PET/MRI has great potential to improve radiotherapy planning (RTP). However, data integration requires imaging with radiotherapy-specific patient positioning. Here, we investigated the feasibility and image quality of radiotherapy-customized PET/MRI in head-and-neck cancer (HNC) patients using a dedicated hardware setup. MATERIAL AND METHODS: Ten HNC patients were examined with simultaneous PET/MRI before treatment, with radiotherapy and diagnostic scan setup, respectively...
May 7, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29564483/voxel-wise-correlation-of-functional-imaging-parameters-in-hnscc-patients-receiving-pet-mri-in-an-irradiation-setup
#4
Kerstin Zwirner, Daniela Thorwarth, René M Winter, Stefan Welz, Jakob Weiss, Nina F Schwenzer, Holger Schmidt, Christian la Fougère, Konstantin Nikolaou, Daniel Zips, Sergios Gatidis
PURPOSE: The purpose of this study was to demonstrate the feasibility of voxel-wise multiparametric characterization of head and neck squamous cell carcinomas (HNSCC) using hybrid multiparametric magnetic resonance imaging and positron emission tomography with [18 F]-fluorodesoxyglucose (FDG-PET/MRI) in a radiation treatment planning setup. METHODS: Ten patients with locally advanced HNSCC were examined with a combined FDG-PET/MRI in an irradiation planning setup...
March 21, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29556677/a-feasibility-study-on-adaptive-18-f-fdg-pet-guided-radiotherapy-for-recurrent-and-second-primary-head-and-neck-cancer-in-the-previously-irradiated-territory
#5
Julie Schatteman, Dirk Van Gestel, Dieter Berwouts, Werner De Gersem, Geert De Kerf, Wilfried De Neve, Bie De Ost, Ana Maria Luiza Olteanu, Sylvie Rottey, Tom Vercauteren, Ingeborg Goethals, Fréderic Duprez
PURPOSE: To evaluate feasibility, disease control, survival, and toxicity after adaptive 18 F-fluorodeoxyglucose (FDG) positron emisson tomography (PET) guided radiotherapy in patients with recurrent and second primary head and neck squamous cell carcinoma. METHODS: A prospective trial investigated the feasibility of adaptive intensity modulated radiotherapy (IMRT) ± concomitant cetuximab in 10 patients. The primary endpoint was achieving a 2-year survival free of grade >3 toxicity in ≥30% of patients...
March 19, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29523427/physiologic-distribution-of-psma-ligand-in-salivary-glands-and-seromucous-glands-of-the-head-and-neck-on-pet-ct
#6
Thomas J W Klein Nulent, Matthijs H Valstar, Bart de Keizer, Stefan M Willems, Laura A Smit, Abrahim Al-Mamgani, Ludwig E Smeele, Robert J J van Es, Remco de Bree, Wouter V Vogel
OBJECTIVES: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is used for detection and (re)staging of prostate cancer. However, healthy salivary, seromucous, and lacrimal glands also have high PSMA-ligand uptake. This study aimed to describe physiologic PSMA-ligand uptake distribution characteristics in the head and neck to aid in PSMA PET/CT interpretation and to identify possible new clinical applications for PSMA-ligand imaging. STUDY DESIGN: Thirty consecutive patients who underwent PSMA PET/CT for prostate cancer were evaluated...
May 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29478080/fdg-pet-ct-for-treatment-response-assessment-in-head-and-neck-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis-of-diagnostic-performance
#7
REVIEW
Nils Helsen, Tim Van den Wyngaert, Laurens Carp, Sigrid Stroobants
PURPOSE: 18-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) is increasingly used to evaluate treatment response in head and neck squamous cell carcinoma (HNSCC). This analysis assessed the diagnostic value of FDG-PET/CT in detecting nodal disease within 6 months after treatment, considering patient and disease characteristics. METHODS: A systematic review was performed using the MEDLINE and Web of Knowledge databases...
June 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29445071/a-case-report-of-thyroid-metastasis-from-p16-positive-oropharyngeal-squamous-cell-carcinoma
#8
Masao Takenobu, Sueyoshi Moritani, Kana Yoshioka, Tsuyoshi Morisaki, Hiroya Kitano
Thyroid metastasis from head and neck squamous cell carcinoma (SCC) is a very rare form of rarely observed metastatic thyroid tumor. We herein report a case of thyroid metastasis from oropharyngeal SCC (OSCC). The patient was a 68-year-old male diagnosed with p16-positive tonsillar OSCC on the right side with multiple lymph node metastases and a thyroid mass, which was determined as metastatic p16-positive OSCC by immunohistochemistry of specimens collected by fine-needle aspiration cytology (FNAC). He received one cycle of induction chemotherapy followed by concurrent chemoradiotherapy...
April 26, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29396680/detection-of-distant-metastases-in-head-and-neck-cancer-changing-landscape
#9
REVIEW
Remco de Bree, Asaf Senft, Andrés Coca-Pelaz, Luiz Kowalski, Fernando Lopez, William Mendenhall, Miquel Quer, Alessandra Rinaldo, Ashok R Shaha, Primož Strojan, Robert P Takes, Carl E Silver, C René Leemans, Alfio Ferlito
As head and neck squamous cell carcinoma (HNSCC) patients with distant metastases (DM) were generally treated only palliatively, the value of screening for DM was usually limited to attempts to avoid extensive locoregional treatment when DM were present pretreatment. Recently, the concept of treating oligometastases, e.g., by metastatectomy or stereotactic body radiotherapy, has been reintroduced for HNSCC and may cause a change in the treatment paradigm. Although whole body 18 F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) combined with computed tomography (CT; WB-FDG-PET/CT) is still the mainstay diagnostic technique, there is a growing body of evidence supporting implementation of whole body magnetic resonance imaging (WB-MRI) as an important diagnostic technique for screening for DM...
February 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29325231/accuracy-of-fdg-pet-ct-response-assessment-following-radiotherapy-alone-for-head-and-neck-squamous-cell-carcinoma-retrospective-analysis-of-45-patients
#10
LETTER
J Philip, E Ermiş, F Slevin, S Vaidyanathan, M Sen, A F Scarsbrook, R J D Prestwich
No abstract text is available yet for this article.
January 11, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29311707/associations-of-tumor-pd-1-ligands-immunohistochemical-studies-and-textural-features-in-18-f-fdg-pet-in-squamous-cell-carcinoma-of-the-head-and-neck
#11
Rui-Yun Chen, Ying-Chun Lin, Wei-Chih Shen, Te-Chun Hsieh, Kuo-Yang Yen, Shang-Wen Chen, Chia-Hung Kao
To know tumor PD-L1 expression through IHC or the FDG-PET related radiomics, we investigated the association between programmed cell death protein 1 ligand (PD-L1) expression and immunohistochemical (IHC) biomarkers or textural features of 18F-fluoro-2-deoxdeoxyglucose positron emission tomography (18 F-FDG PET) in 53 oropharyngeal or hypopharyngeal cancer patients who were ready to undergo radiotherapy-based treatment. Differences in textural features or biomarkers between tumors with and without PD-L1 expression were tested using a Mann-Whitney U test...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29245258/primary-atrial-fibromyxosarcoma-with-multiple-system-metastases-a-case-report
#12
Jingping Qiu, Lingrong Tang, Yang Han, Chun Wang, Tianxiang Gu, Guang Li
RATIONALE: Fibromyxosarcoma is common in head and neck, vessel, omentum, and reproductive system, with low-grade malignant behavior. However, primary atrial fibromyxosarcoma with highly malignant behavior is extremely rare. PATIENT CONCERNS: A 34-year-old female presented with oppression in the chest, short breath, and onset of headache as initial symptoms. The preoperative echocardiogram showed a medium-size echogenic mass close to the posterior leaflet of the mitral valve in the left atrium...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29203116/diagnosis-and-management-of-metastatic-neoplasms-with-unknown-primary
#13
REVIEW
Tilmann Bochtler, Harald Löffler, Alwin Krämer
In cancer of unknown primary (CUP), metastases are clinically and histologically confirmed, but the primary tumor site remains elusive after extensive work-up. CUPs make up for 2-3% of all epithelial malignancies. The two prevailing histologies are adenocarcinomas and undifferentiated carcinomas, whereas squamous cell carcinomas, neuroendocrine carcinomas and rare histologies account for the remaining 10%. The diagnostic work-up in CUP relies strongly on a detailed immunohistological (IHC) analysis in order to characterize the tumor type, nowadays aided by molecular techniques...
May 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29202490/-metastasation-of-cutaneous-squamous-cell-carcinoma-in-the-ent-area
#14
Alexander Dellweg, Thomas Mantei
OBJECTIVES: Our aim was to investigate the metastasis behavior and its prognostic Factor for Survival, with our clinical data. MATERIALS AND METHODS: This retrospective study included 29 Caucasians, with a squamous cell carcinoma of the skin in the head and neck region, at our tertiary clinic between 2004 and 2016. All Patients received a Tumorresection and Neckdissection. We used either Ultrasound or Computer-Tomography (conventional or PET-CT) for our preoperative Staging and the Follow-up...
February 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29187426/-18-f-fdg-pet-guided-planning-and-re-planning-adaptive-radiotherapy-in-head-and-neck-cancer-current-state-of-art
#15
REVIEW
Eleonora Farina, Martina Ferioli, Paolo Castellucci, Arianna Farina, Giuseppe Zanirato Rambaldi, Savino Cilla, Silvia Cammelli, Stefano Fanti, Alessio G Morganti
BACKGROUND/AIM: A review of the literature is proposed as a contribution to current knowledge on technical, physical, and clinical issues about PET-guided planning and re-planning radiotherapy (RT) in head and neck cancer. MATERIALS AND METHODS: PubMed and Scopus electronic databases were searched for articles including clinical trials. Search terms were "gross tumor volume (GTV) delineation", "head and neck cancer", "radiotherapy", "adaptive radiotherapy" in combination with "PET"...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29186937/how-to-use-pet-ct-in-the-evaluation-of-response-to-radiotherapy
#16
Pierre Decazes, Sébastien Thureau, Bernard Dubray, Pierre Vera
INTRODUCTION: Radiotherapy is a major treatment modality for many cancers. Tumor response after radiotherapy determines the subsequent steps of the patient's management (surveillance, adjuvant or salvage treatment and palliative care). Tumor response assessed during radiotherapy offers a promising opportunity to adapt the treatment plan to reduced / increased target volume, to specifically target sub-volumes with relevant biological characteristics (metabolism, hypoxia, proliferation ...
November 28, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29173754/molecular-imaging-guided-radiotherapy-for-the-treatment-of-head-and-neck-squamous-cell-carcinoma-does-it-fulfill-the-promises
#17
REVIEW
Vincent Grégoire, Daniela Thorwarth, John Aldo Lee
With the routine use of intensity modulated radiation therapy for the treatment of head-and-neck squamous cell carcinoma allowing highly conformed dose distribution, there is an increasing need for refining both the selection and the delineation of gross tumor volumes (GTV). In this framework, molecular imaging with positron emission tomography and magnetic resonance imaging offers the opportunity to improve diagnostic accuracy and to integrate tumor biology mainly related to the assessment of tumor cell density, tumor hypoxia, and tumor proliferation into the treatment planning equation...
January 2018: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/29075831/repeatability-of-tumour-hypoxia-imaging-using-18-f-ef5-pet-ct-in-head-and-neck-cancer
#18
Antti Silvoniemi, Sami Suilamo, Timo Laitinen, Sarita Forsback, Eliisa Löyttyniemi, Samuli Vaittinen, Virva Saunavaara, Olof Solin, Tove J Grönroos, Heikki Minn
PURPOSE: Hypoxia contributes to radiotherapy resistance and more aggressive behaviour of several types of cancer. This study was designed to evaluate the repeatability of intratumour uptake of the hypoxia tracer [18 F]EF5 in paired PET/CT scans. METHODS: Ten patients with newly diagnosed head and neck cancer (HNC) received three static PET/CT scans before chemoradiotherapy: two with [18 F]EF5 a median of 7 days apart and one with [18 F]FDG. Metabolically active primary tumour volumes were defined in [18 F]FDG images and transferred to co-registered [18 F]EF5 images for repeatability analysis...
February 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29057432/strategy-and-early-results-of-treatment-of-advanced-cervical-cancer-patients-with-synchronous-cancers-observed-in-pet-ct-imaging
#19
Michał Płachta, Witold Cholewiński, Ewa Burchardt, Paulina Cegła, Bartosz Urbański, Żaneta Wareńczak-Florczak, Andrzej Roszak
OBJECTIVES: The aim of this study was to present strategy and early results of treatment of advanced cervical cancer patients with synchronous cancers observed in PET-CT imaging, treated at the Greater Poland Cancer Center. MATERIAL AND METHODS: The study included a group of 200 patients with diagnosed stage IIB-IIIB cervical cancer who received PET-CT for the purpose of radiotherapy treatment planning. RESULTS: Among our study group, four patients (2%) were found to have a synchronous cancer...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/29029767/pet-ct-and-pet-mri-in-head-and-neck-malignancy
#20
REVIEW
T A Szyszko, G J R Cook
Combined 2-[18 F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET)/computed tomography (CT) has an established role in the staging of difficult cases of head and neck (HN) squamous cell carcinoma (SCC), looking for an unknown primary, assessing response post-chemotherapy at 3-6 months, and differentiating relapse from treatment effects in patients suspected to have tumour recurrence. The PET NECK trial, comparing PET/CT surveillance versus neck dissection in advanced head and neck cancer showed survival was similar among patients who underwent PET/CT-guided surveillance and those who underwent planned neck dissection, but surveillance was more cost-effective...
January 2018: Clinical Radiology
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