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https://www.readbyqxmd.com/read/27833757/a-prospective-multicentre-single-arm-clinical-trial-of-bevacizumab-for-patients-with-surgically-untreatable-symptomatic-brain-radiation-necrosis-%C3%A2
#1
Motomasa Furuse, Naosuke Nonoguchi, Toshihiko Kuroiwa, Susumu Miyamoto, Yoshiki Arakawa, Jun Shinoda, Kazuhiro Miwa, Toshihiko Iuchi, Koji Tsuboi, Kiyohiro Houkin, Shunsuke Terasaka, Yusuke Tabei, Hideo Nakamura, Motoo Nagane, Kazuhiko Sugiyama, Mizuhiko Terasaki, Tatsuya Abe, Yoshitaka Narita, Nobuhito Saito, Akitake Mukasa, Kuniaki Ogasawara, Takaaki Beppu, Toshihiro Kumabe, Tadashi Nariai, Naohiro Tsuyuguchi, Eiji Nakatani, Shoko Kurisu, Yoko Nakagawa, Shin-Ichi Miyatake
BACKGROUND: Brain radiation necrosis (BRN) can be a complication of radiotherapy for primary and secondary brain tumors, as well as head and neck tumors. Since vascular endothelial growth factor (VEGF) is also a vascular permeability factor in the brain, bevacizumab, a humanized antibody that inhibits VEGF, would be expected to reduce perilesional edema that often accompanies BRN. METHODS: Patients with surgically untreatable, symptomatic BRN refractory to conventional medical treatments (eg, corticosteroid, anticoagulants, or hyperbaric oxygen therapy) were enrolled...
December 2016: Neuro-oncology Practice
https://www.readbyqxmd.com/read/27707505/dose-painting-by-numbers-based-on-retrospectively-determined-recurrence-probabilities
#2
Eric Grönlund, Silvia Johansson, Anders Montelius, Anders Ahnesjö
BACKGROUND AND PURPOSE: The aim of this study is to derive "dose painting by numbers" prescriptions from retrospectively observed recurrence volumes in a patient group treated with conventional radiotherapy for head and neck squamous cell carcinoma. MATERIALS AND METHODS: The spatial relation between retrospectively observed recurrence volumes and pre-treatment standardized uptake values (SUV) from fluorodeoxyglucose positron emission tomography (FDG-PET) imaging was determined...
October 1, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27692741/functional-imaging-in-radiotherapy-in-the-netherlands-availability-and-impact-on-clinical-practice
#3
W V Vogel, M G E H Lam, F A Pameijer, U A van der Heide, J B van de Kamer, M E Philippens, M van Vulpen, M Verheij
AIMS: Functional imaging with positron emission tomography/computed tomography (PET/CT) and multiparametric magnetic resonance (mpMR) is increasingly applied for radiotherapy purposes. However, evidence and experience are still limited, and this may lead to clinically relevant differences in accessibility, interpretation and decision making. We investigated the current patterns of care in functional imaging for radiotherapy in the Netherlands in a care evaluation study. MATERIALS AND METHODS: The availability of functional imaging in radiotherapy centres in the Netherlands was evaluated; features available in >80% of academic and >80% of non-academic centres were considered standard of care...
September 27, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27671150/cervical-lymph-node-metastases-of-squamous-cell-carcinoma-of-unknown-origin-the-diagnostic-value-of-fdg-pet-ct-and-clinical-outcome
#4
Einar Dale, Jon M Moan, Terje A Osnes, Trond V Bogsrud
FDG PET/CT is perceived as a valuable diagnostic tool in addition to the standard diagnostic workup for patients with isolated neck lymph nodes of squamous cell carcinoma of unknown primary (SCCUP). For patients with SCCUP intended for primary radiotherapy, we hypothesize that the previously reported FDG PET/CT detection rates are too high. From 2008 to 2015, 30 SCCUP patients were examined with FDG PET/CT. The objective of the FDG PET/CT examination was twofold: (1) improve the radiotherapy target definition, and (2) identify the primary cancer...
September 26, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27638108/an-enhanced-random-walk-algorithm-for-delineation-of-head-and-neck-cancers-in-pet-studies
#5
Alessandro Stefano, Salvatore Vitabile, Giorgio Russo, Massimo Ippolito, Maria Gabriella Sabini, Daniele Sardina, Orazio Gambino, Roberto Pirrone, Edoardo Ardizzone, Maria Carla Gilardi
An algorithm for delineating complex head and neck cancers in positron emission tomography (PET) images is presented in this article. An enhanced random walk (RW) algorithm with automatic seed detection is proposed and used to make the segmentation process feasible in the event of inhomogeneous lesions with bifurcations. In addition, an adaptive probability threshold and a k-means based clustering technique have been integrated in the proposed enhanced RW algorithm. The new threshold is capable of following the intensity changes between adjacent slices along the whole cancer volume, leading to an operator-independent algorithm...
September 16, 2016: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/27609790/feasibility-of-multiparametric-imaging-with-pet-mr-in-head-and-neck-squamous-cell-carcinoma
#6
Jacob H Rasmussen, Martin Nørgaard, Adam E Hansen, Ivan R Vogelius, Marianne C Aznar, Helle H Johannesen, Junia Costa, Astrid Me Engberg, Andreas Kjær, Lena Specht, Barbara M Fischer
PURPOSE: The purpose of this study was to investigate and assess the correlation and the reproducibility of multiparametric imaging in head and neck cancer patients. MATERIAL AND METHODS: Twenty-one patients were included in this prospective scan-rescan study. All patients were scanned twice on an integrated Positron Emission Tomography and Magnetic Resonance imaging scanner (PET/MR). Gross tumor volumes (GTV) were defined on T2-weighted MR images (GTVT2) and volumes of interest were defined on diffusion-weighted magnetic resonance imaging and FDG PET (VOIDWI, VOIPET)...
September 8, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27556178/phase-ii-organ-preservation-trial-concurrent-cisplatin-and-radiotherapy-for-advanced-laryngeal-cancer-after-response-to-docetaxel-cisplatin-and-5-fluorouracil-based-induction-chemotherapy
#7
Aron Popovtzer, Hanna Burnstein, Salomon Stemmer, Dror Limon, Ohad Hili, Gideon Bachar, Vladamir Sopov, Raphael Feinmesser, David Groshar, Jacob Shvero
BACKGROUND: The optimal treatment for locally advanced laryngeal cancer remains controversial. The purpose of this trial was to determine if the response to induction chemotherapy could select patients for organ preservation protocols, and improve larynx-preservation rates without compromising overall survival (OS). METHODS: The cohort comprised 12 patients with T3 disease and 14 with T4. Induction chemotherapy consisted of docetaxel, cisplatin, and 5-fluorouracil (TPF)...
August 24, 2016: Head & Neck
https://www.readbyqxmd.com/read/27469298/a-review-of-the-predictive-role-of-functional-imaging-in-patients-with-mucosal-primary-head-and-neck-cancer-treated-with-radiation-therapy
#8
Myo Min, Peter Lin, Gary Liney, Mark Lee, Dion Forstner, Allan Fowler, Lois Holloway
Advanced radiotherapy techniques, such as intensity-modulated radiotherapy, have been reported to reduce toxicities by improving the dose conformity in mucosal primary head and neck cancer (MPHNC). However, to further optimize the therapeutic ratio, details on individual patient and disease characteristics may be necessary to tailor treatments. This is likely to include identifying poor responders for treatment intensification and good responders for de-escalation strategies. Non-invasive, repeatable imaging biomarkers are attractive modalities in both pre-treatment and intra-treatment response prediction with a view to individualized treatment options...
July 28, 2016: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/27455480/the-feasibility-of-atlas-based-automatic-segmentation-of-mri-for-h-n-radiotherapy-planning
#9
Kieran Wardman, Robin J D Prestwich, Mark J Gooding, Richard J Speight
Atlas-based autosegmentation is an established tool for segmenting structures for CT-planned head and neck radiotherapy. MRI is being increasingly integrated into the planning process. The aim of this study is to assess the feasibility of MRI-based, atlas-based autosegmentation for organs at risk (OAR) and lymph node levels, and to compare the segmentation accuracy with CT-based autosegmentation. Fourteen patients with locally advanced head and neck cancer in a prospective imaging study underwent a T1-weighted MRI and a PET-CT (with dedicated contrast-enhanced CT) in an immobilization mask...
2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27417648/the-predictive-value-of-early-assessment-after-1-cycle-of-induction-chemotherapy-with-18f-fdg-pet-ct-and-diffusion-weighted-mri-for-response-to-radical-chemoradiotherapy-in-head-and-neck-squamous-cell-carcinoma
#10
Kee H Wong, Rafal Panek, Liam Welsh, Dualta Mcquaid, Alex Dunlop, Angela Riddell, Iain Murray, Yong Du, Sue Chua, Dow-Mu Koh, Shreerang Bhide, Chris Nutting, Wim J G Oyen, Kevin Harrington, Kate L Newbold
: The objective of this study was to assess the predictive value of early assessment (after 1 cycle of induction chemotherapy [IC]) with (18)F-FDG PET/CT and diffusion-weighted (DW) MRI for subsequent response to radical chemoradiotherapy in locally advanced head and neck squamous cell carcinoma (HNSCC). METHODS: Twenty patients with stage III-IVa HNSCC prospectively underwent (18)F-FDG PET/CT and DW MRI before and 2 wk after each cycle of IC (first cycle, IC1; second cycle, IC2)...
December 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27416996/role-of-fluorine-18-fluorodeoxyglucose-pet-ct-in-head-and-neck-oncology-the-point-of-view-of-the-radiation-oncologist
#11
Jon Cacicedo, Arturo Navarro, Olga Del Hoyo, Alfonso Gomez-Iturriaga, Filippo Alongi, Jose A Medina, Olgun Elicin, Andrea Skanjeti, Francesco Giammarile, Pedro Bilbao, Francisco Casquero, Berardino de Bari, Alan Dal Pra
Squamous cell carcinoma is the most common malignant tumour of the head and neck. The initial TNM staging, the evaluation of the tumour response during treatment, and the long-term surveillance are crucial moments in the approach to head and neck squamous cell carcinoma (HNSCC). Thus, at each of these moments, the choice of the best diagnostic tool providing the more precise and larger information is crucial. Positron emission tomography with fluorine-18 fludeoxyglucose integrated with CT ((18)F-FDG-PET/CT) rapidly gained clinical acceptance, and it has become an important imaging tool in routine clinical oncology...
November 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27411922/the-expression-of-checkpoint-and-dna-repair-genes-in-head-and-neck-cancer-as-possible-predictive-factors
#12
Orsolya Rusz, Margit Pál, Éva Szilágyi, László Rovó, Zoltán Varga, Bernadett Tomisa, Gabriella Fábián, Levente Kovács, Olga Nagy, Petra Mózes, Zita Reisz, László Tiszlavicz, Péter Deák, Zsuzsanna Kahán
DNA damage response failure may influence the efficacy of DNA-damaging treatments. We determined the expression of 16 genes involved in distinct DNA damage response pathways, in association with the response to standard therapy. Twenty patients with locoregionally advanced, squamous cell head and neck carcinoma were enrolled. The treatment included induction chemotherapy (iChT) with docetaxel, cisplatin and 5-fluorouracil followed by concomitant chemoradiotherapy (ChRT) or radiotherapy (RT) alone. The volumetric metabolic therapeutic response was determined by [18F]FDG-PET/CT...
July 13, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27318684/hypoxia-as-a-biomarker-and-for-personalized-radiation-oncology
#13
Dirk Vordermark, Michael R Horsman
Tumor hypoxia is a clinically relevant cause of radiation resistance. Direct measurements of tumor oxygenation have been performed predominantly with the Eppendorf histograph and these have defined the reduced prognosis after radiotherapy in poorly oxygenated tumors, especially head-and-neck cancer, cervix cancer and sarcoma. Exogenous markers have been used for immunohistochemical detection of hypoxic tumor areas (pimonidazole) or for positron-emission tomography (PET) imaging (misonidazole). Overexpression of hypoxia-related proteins such as hypoxia-inducible factor-1α (HIF-1α) has also been linked to poor prognosis after radiotherapy and such proteins are considered as potential endogenous hypoxia markers...
2016: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27310467/a-nordic-survey-on-the-management-of-head-and-neck-cup
#14
Lovisa Farnebo, Göran Laurell, Antti Mäkitie
CONCLUSION: The management of Head and Neck Cancer of Unknown Primary (HNCUP) patients varies both between centres within and also between the Nordic countries. This study contributes to a continuing discussion of how to improve the accuracy of diagnosis and quality of treatment of HNCUP patients. OBJECTIVES: The initiative for this study was based on the lack of common guidelines for diagnostic procedures and for treatment of HNCUP patients in the Nordic countries constituting a region having a rather homogeneous population...
June 16, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27253509/targeting-hypoxia-to-overcome-radiation-resistance-in-head-neck-cancers-real-challenge-or-clinical-fairytale
#15
René Baumann, Reinhard Depping, Marc Delaperriere, Juergen Dunst
INTRODUCTION: Tumor hypoxia is a major cause for failure of therapy in patients with inoperable head and neck cancers. AREAS COVERED: Various anti-hypoxic treatment strategies (e.g. hyperbaric oxygenation, hypoxic cell sensitizers) have been tested in clinical trials in head and neck cancer over the past 30 years and have shown modest improvements in combination with radiotherapy in meta-analyses. Anemia worsens tumor hypoxia, but anemia correction had no significant effect...
July 2016: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/27251644/the-reoxygenation-of-hypoxia-and-the-reduction-of-glucose-metabolism-in-head-and-neck-cancer-by-fractionated-radiotherapy-with-intensity-modulated-radiation-therapy
#16
Shozo Okamoto, Tohru Shiga, Koichi Yasuda, Shiro Watanabe, Kenji Hirata, Ken-Ichi Nishijima, Keiichi Magota, Katsuhiko Kasai, Rikiya Onimaru, Kazuhiko Tuchiya, Yuji Kuge, Hiroki Shirato, Nagara Tamaki
PURPOSE: The purpose of this study was to prospectively investigate reoxygenation in the early phase of fractionated radiotherapy and serial changes of tumoricidal effects associated with intensity-modulated radiation therapy (IMRT) in patients with head and neck cancer (HNC) using F-18 fluoromisonidazole (FMISO) PET and F-18 fluorodeoxyglucose (FDG) PET. METHODS: Patients with untreated HNC underwent FMISO-PET and FDG-PET studies prospectively. A PET evaluation was conducted before each IMRT (Pre-IMRT), during IMRT (at 30 Gy/15 fr) (Inter-IMRT), and after completion of IMRT (70 Gy/35 fr) (Post-IMRT)...
November 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27251643/evaluation-of-tumour-hypoxia-during-radiotherapy-using-18-f-hx4-pet-imaging-and-blood-biomarkers-in-patients-with-head-and-neck-cancer
#17
Catharina M L Zegers, Frank J P Hoebers, Wouter van Elmpt, Judith A Bons, Michel C Öllers, Esther G C Troost, Daniëlle Eekers, Leo Balmaekers, Marlies Arts-Pechtold, Felix M Mottaghy, Philippe Lambin
BACKGROUND AND PURPOSE: Increased tumour hypoxia is associated with a worse overall survival in patients with head and neck squamous cell carcinoma (HNSCC). The aims of this study were to evaluate treatment-associated changes in [(18)F]HX4-PET, hypoxia-related blood biomarkers, and their interdependence. MATERIAL AND METHODS: [(18)F]HX4-PET/CT scans of 20 patients with HNSCC were acquired at baseline and after ±20Gy of radiotherapy. Within the gross-tumour-volumes (GTV; primary and lymph nodes), mean and maximum standardized uptake values, the hypoxic fraction (HF) and volume (HV) were calculated...
November 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27219720/influence-of-fdg-pet-on-primary-nodal-target-volume-definition-for-head-and-neck-carcinomas
#18
Sylvia L van Egmond, Vera Piscaer, Luuk M Janssen, Inge Stegeman, Monique G Hobbelink, Wilko Grolman, Chris H Terhaard
BACKGROUND: The role of 2-[(18)F]-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in routine diagnostic staging remains controversial. In case of discordance between FDG-PET and CT, a compromise has to be made between the risk of false positive FDG-PET and the risk of delaying appropriate salvage intervention. Second, with intensity modulated radiation therapy (IMRT), smaller radiation fields allow tissue sparing, but could also lead to more marginal failures...
May 24, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27180092/total-mucosal-irradiation-with-intensity-modulated-radiotherapy-in-patients-with-head-and-neck-carcinoma-of-unknown-primary-a-pooled-analysis-of-two-prospective-studies
#19
T M Richards, S A Bhide, A B Miah, L Del Rosario, S Bodla, K Thway, D M Gujral, K P Rooney, U Schick, T McGovern, L Grove, K L Newbold, K J Harrington, C M Nutting
AIMS: To determine the clinical outcomes of an intensity-modulated radiotherapy technique for total mucosal irradiation (TM-IMRT) in patients with head and neck carcinoma of unknown primary (HNCUP). MATERIALS AND METHODS: A single-centre prospective phase II trial design was used in two sequential studies to evaluate TM-IMRT for HNCUP. Patients were investigated for primary tumour site using examination under anaesthetic and biopsies, computed tomography ± magnetic resonance imaging (MRI) or 18-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT)...
September 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27156741/modern-radiology-in-the-management-of-head-and-neck-cancer
#20
G J C Burkill, R M Evans, V V Raman, S E J Connor
The accurate staging of head and neck cancer is vital to direct appropriate management strategies and to deliver the best radiation therapy and surgery. Initial challenges in head and neck cancer imaging include determination of T- and N-stage, stage migration with detection of metastatic disease and identification of primary disease in the patient presenting with nodal metastases. In follow-up, imaging has an important role in assessing patients who may require salvage surgery after radiotherapy and assessing clinical change that may represent either residual/recurrent disease or radiation effects...
July 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
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