Philippe Connes, Berenike Möckesch, Emilienne Tudor Ngo Sock, Marie-Dominique Hardy-Dessources, Karen Reminy, Sarah Skinner, Marie Billaud, Elie Nader, Benoit Tressieres, Maryse Etienne-Julan, Nicolas Guillot, Nathalie Lemonne, Olivier Hue, Marc Romana, Sophie Antoine-Jonville
Inflammation and oxidative stress play a key role in the pathophysiology of sickle cell disease (SCD). However, the potential influence of different sickle genotypes, or hydroxyurea (HU) treatment, on these factors remains poorly documented. The present study compared several plasma markers of inflammation and oxidative stress, as well as microvascular function, between patients with sickle SC disease (HbSC, n = 19) and patients with sickle cell anemia (HbSS) under hydroxyurea (HU) treatment (n = 16), or not (n = 13)...
June 2021: European Journal of Haematology