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Intelligent design

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https://www.readbyqxmd.com/read/29242609/automating-drug-discovery
#1
REVIEW
Gisbert Schneider
Small-molecule drug discovery can be viewed as a challenging multidimensional problem in which various characteristics of compounds - including efficacy, pharmacokinetics and safety - need to be optimized in parallel to provide drug candidates. Recent advances in areas such as microfluidics-assisted chemical synthesis and biological testing, as well as artificial intelligence systems that improve a design hypothesis through feedback analysis, are now providing a basis for the introduction of greater automation into aspects of this process...
December 15, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29238546/receptor-uptake-arrays-for-vitamin-b12-siderophores-and-glycans-shape-bacterial-communities
#2
REVIEW
Steven A Frank
Molecular variants of vitamin B12, siderophores, and glycans occur. To take up variant forms, bacteria may express an array of receptors. The gut microbe Bacteroides thetaiotaomicron has three different receptors to take up variants of vitamin B12 and 88 receptors to take up various glycans. The design of receptor arrays reflects key processes that shape cellular evolution. Competition may focus each species on a subset of the available nutrient diversity. Some gut bacteria can take up only a narrow range of carbohydrates, whereas species such as B...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29238234/development-of-a-psychological-test-to-measure-ability-based-emotional-intelligence-in-the-indonesian-workplace-using-an-item-response-theory
#3
Fajrianthi, Rizqy Amelia Zein
This study aimed to develop an emotional intelligence (EI) test that is suitable to the Indonesian workplace context. Airlangga Emotional Intelligence Test (Tes Kecerdasan Emosi Airlangga [TKEA]) was designed to measure three EI domains: 1) emotional appraisal, 2) emotional recognition, and 3) emotional regulation. TKEA consisted of 120 items with 40 items for each subset. TKEA was developed based on the Situational Judgment Test (SJT) approach. To ensure its psychometric qualities, categorical confirmatory factor analysis (CCFA) and item response theory (IRT) were applied to test its validity and reliability...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/29235364/patient-reported-safety-incidents-as-a-new-source-of-patient-safety-data-an-exploratory-comparative-study-in-an-acute-hospital-in-england
#4
Gerry Armitage, Sally Moore, Caroline Reynolds, Pierre-Antoine Laloë, Claire Coulson, Rosie McEachan, Rebecca Lawton, Ian Watt, John Wright, Jane O'Hara
Objectives To compare a new co-designed, patient incident reporting tool with three established methods of detecting patient safety incidents and identify if the same incidents are recorded across methods. Method Trained research staff collected data from inpatients in nine wards in one university teaching hospital during their stay. Those classified as patient safety incidents were retained. We then searched for patient safety incidents in the corresponding patient case notes, staff incident reports and reports to the Patient Advice and Liaison Service specific to the study wards...
January 1, 2017: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/29235355/facile-fabrication-of-electrically-conductive-low-density-polyethylene-carbon-fiber-tubes-for-novel-smart-materials-via-multi-axial-orientation
#5
Yijun Li, Min Nie, Qi Wang
Electromechanical sensors are indispensable components in functional devices and robotics application. However, the fabrication of the sensors still maintain a challenging issue that high percolation threshold and easy failure of conductive network are derived from uniaxial orientation of conductive fillers in practical melt processing. Herein, we reported a facile fabrication method to prepare multi-axial low density polyethylene (LDPE) /carbon fibers (CFs) tube with bidirectional controllable electrical conductivity and sensitive strain-responsive performance via rotation extrusion technology...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29230060/natural-erosion-of-sandstone-as-shape-optimisation
#6
Igor Ostanin, Alexander Safonov, Ivan Oseledets
Natural arches, pillars and other exotic sandstone formations have always been attracting attention for their unusual shapes and amazing mechanical balance that leave a strong impression of intelligent design rather than the result of a stochastic process. It has been recently demonstrated that these shapes could have been the result of the negative feedback between stress and erosion that originates in fundamental laws of friction between the rock's constituent particles. Here we present a deeper analysis of this idea and bridge it with the approaches utilized in shape and topology optimisation...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228834/quality-of-life-and-its-related-factors-for-adults-with-autism-spectrum-disorder
#7
Ling-Yi Lin, Pai-Chuan Huang
PURPOSE: Improved quality of life is an important outcome for adults with autism spectrum disorder. However, little research has examined factors associated with quality of life among adults with autism spectrum disorder. METHOD: This study comparing 66 adults with autism spectrum disorder (intelligence quotient > 70) aged 20-38 years with neuro-typical adults investigated their quality of life and related factors. All the participants were interviewed with questionnaires by a registered occupational therapist...
December 11, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29226844/an-intelligent-1-2-demultiplexer-as-an-intracellular-theranostic-device-based-on-dna-ag-clusters-gated-nanovehicles
#8
Xiang Ran, Zhenzhen Wang, Enguo Ju, Fang Pu, Yanqiu Song, Xiaogang Qu, Jinsong Ren
The logic device demultiplexer can convey a single input signal into one of multiple output channels. The choice of the output channel is controlled by a selector. Several molecules and biomolecules have been used to mimic the function of a demultiplexer. However, the practical application of logic devices still remains a big challenge. Herein, we design and construct an intelligent 1:2 demultiplexer as a theranostic device based on azobenzene-modified and DNA/Ag clusters-gated nanovehicles. The configuration of azobenzene (azo) and the conformation of DNA ensemble can be regulated by light irradiation and pH, respectively...
December 11, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29224774/australian-children-with-cleft-palate-achieve-age-appropriate-speech-by-5-years-of-age
#9
Antonia Chacon, Melissa Parkin, Kate Broome, Alison Purcell
INTRODUCTION: Children with cleft palate demonstrate atypical speech sound development, which can influence their intelligibility, literacy and learning. There is limited documentation regarding how speech sound errors change over time in cleft palate speech and the effect that these errors have upon mono-versus polysyllabic word production. The objective of this study was to examine the phonetic and phonological speech skills of children with cleft palate at ages 3 and 5. METHODS: A cross-sectional observational design was used...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29223036/study-on-temperature-and-near-infrared-driving-characteristics-of-hydrogel-actuator-fabricated-via-molding-and-3d-printing
#10
Qian Zhao, Yunhong Liang, Lei Ren, Feng Qiu, Zhihui Zhang, Luquan Ren
A hydrogel material system which was fit for molding and 3D printing was developed to fabricate bilayer hydrogel actuators with controllable temperature and near infrared laser responses. Polymerization on interface boundary of layered structure enhanced the bonding strength of hydrogel actuators. By utilizing anisotropic of microstructure along with thickness direction, bilayer hydrogel actuators fabricated via molding realized intelligent bending/shrinking responses, which guided the preparation of hydrogel ink for 3D printing...
December 2, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29222966/optimizing-functional-outcomes-in-mandibular-condyle-reconstruction-with-the-free-fibula-flap-using-computer-aided-design-and-manufacturing-technology
#11
Z-Hye Lee, Tomer Avraham, Casian Monaco, Ashish A Patel, David L Hirsch, Jamie P Levine
PURPOSE: Mandibular defects involving the condyle represent a complex reconstructive challenge for restoring proper function of the temporomandibular joint (TMJ) because it requires precise bone graft alignment for full restoration of joint function. The use of computer-aided design and manufacturing (CAD/CAM) technology can aid in accurate reconstruction of mandibular condyle defects with a vascularized free fibula flap without the need for additional adjuncts. The purpose of this study was to analyze clinical and functional outcomes after reconstruction of mandibular condyle defects using only a free fibula graft with the help of virtual surgery techniques...
November 15, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29215711/triage-tools-for-detecting-cervical-spine-injury-in-pediatric-trauma-patients
#12
REVIEW
Annelie Slaar, M M Fockens, Junfeng Wang, Mario Maas, David J Wilson, J Carel Goslings, Niels Wl Schep, Rick R van Rijn
BACKGROUND: Pediatric cervical spine injury (CSI) after blunt trauma is rare. Nonetheless, missing these injuries can have severe consequences. To prevent the overuse of radiographic imaging, two clinical decision tools have been developed: The National Emergency X-Radiography Utilization Study (NEXUS) criteria and the Canadian C-spine Rule (CCR). Both tools are proven to be accurate in deciding whether or not diagnostic imaging is needed in adults presenting for blunt trauma screening at the emergency department...
December 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29214479/cities-of-the-future-bionic-systems-of-new-urban-environment
#13
Alicja Edyta Krzemińska, Anna Danuta Zaręba, Anna Dzikowska, Katarzyna Rozalia Jarosz
The concepts of the cities we know nowadays, and which we are accustomed to, change at a very rapid pace. The philosophy of their design is also changing. It will base on new standards, entering a completely different, futuristic dimension. This stage is related to changes in the perception of space, location and lack of belonging to definite, national or cultural structures. Cities of the future are cities primarily intelligent, zero-energetic, zero-waste, environmentally sustainable, self-sufficient in terms of both organic food production and symbiosis between the environment and industry...
December 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29212480/the-effect-of-nursing-participation-in-the-design-of-a-critical-care-information-system-a-case-study-in-a-chinese-hospital
#14
Yanhong Qin, Ranyun Zhou, Qiong Wu, Xiaodi Huang, Xinli Chen, Weiwei Wang, Xun Wang, Hua Xu, Jing Zheng, Siyu Qian, Changqing Bai, Ping Yu
BACKGROUND: Intensive care information systems (ICIS) are continuously evolving to meet the ever changing information needs of intensive care units (ICUs), providing the backbone for a safe, intelligent and efficient patient care environment. Although beneficial for the international advancement in building smart environments to transform ICU services, knowledge about the contemporary development of ICIS worldwide, their usage and impacts is limited. This study aimed to fill this knowledge gap by researching the development and implementation of an ICIS in a Chinese hospital, nurses' use of the system, and the impact of system use on critical care nursing processes and outcomes...
December 6, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29204917/the-outcome-of-cochlear-implantation-among-children-with-genetic-syndromes
#15
Farid Alzhrani, Rayan Alhussini, Rawan Hudeib, Tuqa Alkaff, Tahera Islam, Abdulrahman Alsanosi
OBJECTIVE: To assess the outcome and efficacy of cochlear implantation in children with genetic syndromes. METHOD: Study design: case-control study. SETTING: A cochlear implantation tertiary referral center. PATIENTS: All pediatric cochlear implantation recipients with Waardenburg syndrome, Usher syndrome, Dandy-Walker syndrome, or albinism. A control group was appropriately matched to the syndromic group with regard to age at implantation and duration of device use...
December 4, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29203440/car-t-cells-and-combination-therapies-what-s-next-in-the-immunotherapy-revolution
#16
Maria C Ramello, Eric B Haura, Daniel Abate-Daga
Cancer immunotherapies are dramatically reshaping the clinical management of oncologic patients. For many of these therapies, the guidelines for administration, monitoring, and management of associated toxicities are still being established. This is especially relevant for adoptively transferred, genetically-modified T cells, which have unique pharmacokinetic properties, due to their ability to replicate and persist long-term, following a single administration. Furthermore, in the case of CAR-T cells, the use of synthetic immune receptors may impact signaling pathways involved in T cell function and survival in unexpected ways...
December 1, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29202226/stretchable-ti3c2tx-mxene-carbon-nanotubes-composite-based-strain-sensor-with-ultrahigh-sensitivity-and-tunable-sensing-range
#17
Yichen Cai, Jie Shen, Gang Ge, Yizhou Zhang, Wanqin Jin, Wei Huang, Jinjun Shao, Jian Yang, Xiaochen Dong
It remains challenging to fabricate strain-sensing materials and exquisite geometric constructions for integrating extraordinary sensitivity, low strain detectability, high stretchability, tunable sensing range, thin device dimensions into a single type of strain sensor. A percolation network based on Ti3C2Tx MXene/carbon nanotubes (CNTs) composites was rationally designed and fabricated into versatile strain sensors. This weaving architecture with excellent electric properties combined the sensitive two-dimensional (2D) Ti3C2Tx MXene nanostacks with conductive and stretchable one-dimensional (1D) CNTs crossing...
December 4, 2017: ACS Nano
https://www.readbyqxmd.com/read/29200409/falls-in-hospitalized-children-with-neurodevelopmental-conditions-a-cross-sectional-correlational-study
#18
Francesco Craig, Rosanna Castelnuovo, Rossella Pacifico, Rosaria Leo, Antonio Trabacca
PURPOSE: The aim of the current study was to investigate in-hospital falls among children with neurological or neurodevelopmental conditions and investigated associated child characteristics. DESIGN: A cross-sectional, correlational study design was used in this study. A total of 446 patients were enrolled in the study, of which 298 were admitted with neurological conditions and 148 with neurodevelopmental conditions. METHODS: Intelligent quotient (IQ) was assessed according to age, and the Humpty Dumpty Falls Scale (HDFS) was completed and scored for each participant...
October 4, 2017: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/29199840/an-examination-of-sex-differences-on-neurocognitive-functioning-and-behavior-problems-in-maltreated-youth
#19
Kate B Nooner, Stephen R Hooper, Michael D De Bellis
OBJECTIVE: In the developmental traumatology model, the biological construct of sex is considered a moderator that may negatively influence child maltreatment sequelae including those pertaining to neurocognitive function. METHOD: This study examined sex-differences in neurocognitive function and behavior problems in maltreated boys (n = 42), maltreated girls (n = 56) versus nonmaltreated boys (n = 45) and girls (n = 59). Maltreated boys were hypothesized to have poorer neurocognitive functioning than maltreated girls, and nonmaltreated boys and girls, in all neurocognitive domains, particularly pertaining to executive function and attention...
December 4, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29197693/longitudinal-safety-evaluation-of-electric-vehicles-with-the-partial-wireless-charging-lane-on-freeways
#20
Ye Li, Wei Wang, Lu Xing, Qi Fan, Hao Wang
As an environment friendly transportation mode, the electric vehicle (EV) has drawn an increasing amount of attention from governments, vehicle manufactories and researchers recently. One of the biggest issue impeding EV's popularization associates with the charging process. The wireless charging lane (WCL) has been proposed as a convenient charging facility for EVs. Due to the high costs, the application of WCL on the entire freeways is impractical in the near future, while the partial WCL (PWCL) may be a feasible solution...
November 30, 2017: Accident; Analysis and Prevention
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