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Zoltán Fábián, György Szabó, Cecilia Petrovan, Karin Ursula Horváth, Botond Babicsák, Kálmán Hüttl, Zsolt Németh, Sándor Bogdán
Intraosseous vascular malformations (VascM) of the facial skeleton are rare entities, raising difficulties even today in their treatment. We present a case for zygomatic intraosseous venous malformation of traumatic etiology with growth dynamics presentation and a multidisciplinary treatment approach, with intravascular embolization surgical ablation and primary reconstructruction using a titanium patient-specific implant (PSI), and a review of the literature for intraosseous vascular lesions of the facial skeleton focusing on the diagnostic syntagms used by the involved medical personnel, to shed light on the confusions over these terms...
April 13, 2018: Oral and Maxillofacial Surgery
Liangsheng Wang, Dong Liu
Phosphorus is essential for plant growth and development, but levels of inorganic phosphate (Pi), the major form of phosphorus that plants assimilate, are quite limiting in most soils. To cope with Pi deficiency, plants trigger a suite of adaptive responses, including the induction and secretion of acid phosphatases (APases). In this article, we describe how Pi starvation-induced (PSI) APases are analyzed, and we provide a brief historical review of their identification. We then discuss the current understanding of the functions of PSI-secreted APases and how these APases are regulated at the molecular level...
June 2018: Plant Science: An International Journal of Experimental Plant Biology
Rachael Allen, Cara T Motz, Andrew Feola, Kyle Chesler, Raza Haider, Sringanesh Ramachandra Rao, Lara Skelton, Steven Fliesler, Machelle T Pardue
Acoustic blast overpressure (ABO) injury in military personnel and civilians is often accompanied by delayed visual deficits. However, most animal model studies dealing with blast-induced visual defects have focused on short-term (≤1 month) changes. Here, we evaluated long-term (≤8 months) retinal structure and function deficits in rats with ABO injury. Adult male Long Evans rats were subjected to ABO from a single blast (∼ 190 dB SPL, ∼ 63 kPa, @80 psi), generated by a shock tube device. Retinal function (electroretinography), visual function (optokinetic tracking), retinal thickness (spectral domain-optical coherence tomography), and spatial cognition/exploratory motor behavior (Y-maze) were measured at 2, 4, 6, and 8 months post-blast...
March 6, 2018: Journal of Neurotrauma
Michael K K Leung, Andrew Delong, Brendan J Frey
Motivation: Processing of transcripts at the 3'-end involves cleavage at a polyadenylation site followed by the addition of a poly(A)-tail. By selecting which site is cleaved, the process of alternative polyadenylation enables genes to produce transcript isoforms with different 3'-ends. To facilitate the identification and treatment of disease-causing mutations that affect polyadenylation and to understand the sequence determinants underlying this regulatory process, a computational model that can accurately predict polyadenylation patterns from genomic features is desirable...
April 10, 2018: Bioinformatics
M Sivade Dumousseau, M Koch, A Shrivastava, D Alonso-López, J De Las Rivas, N Del-Toro, C W Combe, B H M Meldal, J Heimbach, J Rappsilber, J Sullivan, Y Yehudi, S Orchard
BACKGROUND: A number of different molecular interactions data download formats now exist, designed to allow access to these valuable data by diverse user groups. These formats include the PSI-XML and MITAB standard interchange formats developed by Molecular Interaction workgroup of the HUPO-PSI in addition to other, use-specific downloads produced by other resources. The onus is currently on the user to ensure that a piece of software is capable of read/writing all necessary versions of each format...
April 11, 2018: BMC Bioinformatics
M Sivade Dumousseau, D Alonso-López, M Ammari, G Bradley, N H Campbell, A Ceol, G Cesareni, C Combe, J De Las Rivas, N Del-Toro, J Heimbach, H Hermjakob, I Jurisica, M Koch, L Licata, R C Lovering, D J Lynn, B H M Meldal, G Micklem, S Panni, P Porras, S Ricard-Blum, B Roechert, L Salwinski, A Shrivastava, J Sullivan, N Thierry-Mieg, Y Yehudi, K Van Roey, S Orchard
BACKGROUND: Systems biologists study interaction data to understand the behaviour of whole cell systems, and their environment, at a molecular level. In order to effectively achieve this goal, it is critical that researchers have high quality interaction datasets available to them, in a standard data format, and also a suite of tools with which to analyse such data and form experimentally testable hypotheses from them. The PSI-MI XML standard interchange format was initially published in 2004, and expanded in 2007 to enable the download and interchange of molecular interaction data...
April 11, 2018: BMC Bioinformatics
Seshadri Ramkiran, Mathews Jacob, Manish Honwad, Desiraju Vivekanand, Mathangi Krishnakumar, Seema Patrikar
Background: Pain associated with laparoscopic cholecystectomy is most severe during the first 24 h and the port sites are the most painful. Recent multimodal approaches target incisional pain instead of visceral pain which has led to the emergence of abdominal fascial plane blocks. This study embraces a novel combination of two independently effective fascial plane blocks, namely rectus sheath block and subcostal transversus abdominis plane (TAP) block to alleviate postoperative pain...
January 2018: Anesthesia, Essays and Researches
Hiroyuki Miyazaki, Nobuhiko Nagata, Takanori Akagi, Satoshi Takeda, Taishi Harada, Shinichiro Ushijima, Takashi Aoyama, Yuji Yoshida, Hiroshi Yatsugi, Masaki Fujita, Kentaro Watanabe
PURPOSE: This study aimed to elucidate factors related to 30-day mortality of pneumonia occurring outside hospital by comprehensively analyzing data considered relevant to prognosis. METHODS: Data considered relevant to prognosis were retrospectively examined from clinical charts and chest X-ray images of all patients with pneumonia occurring outside hospital admitted to our hospital from 2010 to 2016. The primary outcome was 30-day mortality. RESULTS: Data were collected from 534 patients (317 community-acquired pneumonia and 217 nursing- and healthcare associated pneumonia patients; 338 men (63...
April 5, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Rui Liu, Wei Li, Tingting Cai, Yang Deng, Zhi Ding, Yan Liu, Xuerui Zhu, Xin Wang, Jie Liu, Baowen Liang, Tiesong Zheng, Jianlin Li
A new aptamer microarray method on the TiO2-porous silicon (PSi) surface was developed to simultaneously screen multiplex mycotoxins. TiO2 nano-layer on the surface of PSi can enhance 14 times fluorescence intensity than that of the thermally oxidized PSi. The aptamer fluorescence signal recovery principle was performed on the TiO2-PSi surface by hybridization duplex strand DNA from mycotoxin aptamer and anti-aptamer respectively labeled with fluorescence dye and quencher. The aptamer microarray can simultaneously screen for multiplex mycotoxins with a dynamic linear detection range of 0...
April 6, 2018: ACS Applied Materials & Interfaces
Artur Stolarczyk, Lukasz Nagraba, Tomasz Mitek, Magda Stolarczyk, Jarosław Michał Deszczyński, Maciej Jakucinski
Alignment of the prosthesis is one of the most significant factors that affect the long-term clinical outcome following total knee arthroplasty (TKA). There is conflicting evidence whether patient-specific instrumentation (PSI) for TKA improves the component position compared to standard instrumentation. This study aimed to compare the rotational alignment of the femoral and tibial components in TKA patients when performed with either conventional or PSI. Sixty patients with primary knee osteoarthritis were randomly divided into two groups treated surgically with TKA: one with conventional instrumentation and the other with the Visionaire PSI system (Smith and Nephew, Memphis, TN)...
April 6, 2018: Advances in Experimental Medicine and Biology
Lisa A Jacobson, E Mark Mahone, Keith O Yeates, M Douglas Ris
The current study examined processing speed in children two years post-treatment for brain tumors (BT) with radiation therapy (RT) compared to those treated with without RT. Participants included 59 children (4-17 years) with BT assessed as part of the Brain Radiation Investigative Study Consortium (BRISC). Processing speed was assessed at two time points: Time1 (3-9 months post-surgery) for 26 children who received whole brain or focal RT (RT group) and 33 treated without RT (no-RT group), and again two years later (Time2) for 42 participants (17 RT, 25 no-RT)...
April 6, 2018: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
Muruganantham Mookkan
Setaria viridis is one of the most important model grasses in studying monocot plant biology. Transient gene expression study is a very important tool in plant biotechnology, functional genomics, and CRISPR-Cas9 genome editing technology via particle bombardment. In this study, a particle bombardment-mediated protocol was developed to introduce DNA into Setaria viridis in vitro leaf explants. In addition, physical and biological parameters, such as helium pressure, distance from stopping screen to the target tissues, DNA concentration, and number of bombardments, were tested and optimized...
April 5, 2018: Plant Signaling & Behavior
Wojciech Giera, Sebastian Szewczyk, Michael D McConnell, Kevin E Redding, Rienk van Grondelle, Krzysztof Gibasiewicz
Energetic properties of chlorophylls in photosynthetic complexes are strongly modulated by their interaction with the protein matrix and by inter-pigment coupling. This spectral tuning is especially striking in photosystem I (PSI) complexes that contain low-energy chlorophylls emitting above 700 nm. Such low-energy chlorophylls have been observed in cyanobacterial PSI, algal and plant PSI-LHCI complexes, and individual light-harvesting complex I (LHCI) proteins. However, there has been no direct evidence of their presence in algal PSI core complexes lacking LHCI...
April 4, 2018: Photosynthesis Research
Roy Tal, Kineret Tal, Ohad Green
Sexual abuse by a perpetrator outside of the family is the most prevalent form of child sexual abuse. It is associated with serious consequences for both the child and his family. Surprisingly, however, the issue of extra-familial sexual abuse has received very little research and clinical attention. The purpose of the current study was to explore the effectiveness of Child-Parent Relationship Therapy (CPRT), which uses nondirective play therapy tools, among parents of extra-familial abused children and their parents...
April 4, 2018: Journal of Child Sexual Abuse
Jinlan Gao, Hao Wang, Qipeng Yuan, Yue Feng
Photosynthesis converts solar energy into chemical energy to sustain all life on earth by providing oxygen and food, and controlling the atmospheric carbon dioxide. During this process, the water-splitting and oxygen-evolving reaction is catalyzed by photosystem II (PSII), while photosystem I (PSI) generates the reducing power for the reduction of NADP+ to NADPH. Together with their peripheral light-harvesting complexes (LHCs), photosystems function as multisubunit supercomplexes located in the thylakoid membranes of cyanobacteria, algae, and plants...
2018: Frontiers in Plant Science
Kenneth B Gordon, April W Armstrong, M Alan Menter, Jashin J Wu
For many patients, the new biologic therapies for psoriasis can improve Psoriasis Area and Severity Index (PASI) scores in a relatively short time. But when results are less than optimal, patients often become frustrated. By providing effective medical treatment using a treat-to-target strategy, clinicians can relieve symptoms and halt disease progression. Although body surface area (BSA) and PASI scores are appropriate for analyzing results of clinical trials, clinicians need to use more patient-centered assessments of patients' progress such as the Dermatology Life Quality Index (DLQI) and Psoriasis Symptom Inventory (PSI), as well as other validated patientreported outcomes, which can enable them to set realistic and achievable goals for individual patients...
February 2018: Seminars in Cutaneous Medicine and Surgery
Rocio Torres, Virginia E Diz, M Gabriela Lagorio
Effects of gold nanoparticles (average diameter: 10-14 nm) on leaves and chloroplasts have been studied. Gold nanoparticles (AuNPs) quenched significantly chlorophyll fluorescence when introduced both in intact leaves and isolated chloroplasts. Additionally, the fluorescence spectra corrected for light re-absorption processes showed a net decrease in the fluorescence ratio calculated as the quotient between the maximum fluorescence at 680 and 735 nm. This fact gave evidence for a reduction in the fluorescence emission of the PSII relative to that of the PSI...
April 3, 2018: Photochemical & Photobiological Sciences
Hisako Kubota-Kawai, Risa Mutoh, Kanako Shinmura, Pierre Sétif, Marc M Nowaczyk, Matthias Rögner, Takahisa Ikegami, Hideaki Tanaka, Genji Kurisu
Photosystem I (PSI), a large protein complex located in the thylakoid membrane, mediates the final step in light-driven electron transfer to the stromal electron carrier protein ferredoxin (Fd). Here, we report the first structural description of the PSI-Fd complex from Thermosynechococcus elongatus. The trimeric PSI complex binds three Fds in a non-equivalent manner. While each is recognized by a PSI protomer in a similar orientation, the distances between Fds and the PSI redox centres differ. Fd binding thus entails loss of the exact three-fold symmetry of the PSI's soluble subunits, inducing structural perturbations which are transferred to the lumen through PsaF...
April 2, 2018: Nature Plants
Hongri Xu, Meng Li, Chengxiang Wang, Renyi Yin, Jie Ma, Mingzhe Wang, Quan Ming Tan, Liangduo Jiang, Miao Cheng, Xianhai Chen, Lishan Zhang, Huiping Su, Ruifu Hao, Yang Jiao, Caihua Wang, Hanlin Wei, Cuiling Feng, Hui Luo, Chuanyun Ren, Shaozhong Zhou, Shengxian Wu, Pingan Zhou
OBJECTIVE: To evaluate the efficacy and safety of Fuzheng Jiedu Huayu Decoction (FJHD) in treating pneumonia in the elderly. METHODS: Adopting a multi-center, double-blind, parallel, randomized controlled trial, 284 elderly pneumonia patients were enrolled and randomly allocated to the standard treatment with FJHD (treatment group, TG) and the standard treatment with placebo group (control group, CG). Efficacy and safety was evaluated through mortality rate, curative rate, symptom improvement, chest X-ray (CXR) lesion absorption, arterial blood gas (ABG), peripheral blood leukocyte count (PBLC) and adverse events...
April 2018: Complementary Therapies in Medicine
Ya-Hui Hsieh, Fang-Yi Liao, Yuan-Han Yang, Jing-Ru Weng, Su-Hwei Chen, Chia-Hsien Feng
A simple cyclodextrin-mediated capillary zone electrophoresis method equipped with a laser-induced fluorescence detector was developed for chiral analysis of the excitatory amino acids aspartate (Asp) and glutamate (Glu). Plasma and cerebrospinal fluid (CSF) samples were pretreated with centrifugal filter devices before analysis to remove high-molecular-weight proteins (molecular weight cut-off: 3000) and then derivatized using 10 mM 6-carboxyfluorescein N-hydroxysuccinimide ester in DMSO under sonication at 25 °C for 2 h...
March 23, 2018: Journal of Chromatography. A
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