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https://www.readbyqxmd.com/read/27934159/tailored-dual-pegylation-of-inorganic-porous-nanocarriers-for-extremely-long-blood-circulation-in-vivo
#1
Tuomo Nissinen, Simo Näkki, Hanne Laakso, Dalius Kučiauskas, Algirdas Kaupinis, Mikko I Kettunen, Timo Liimatainen, Mervi Hyvönen, Mindaugas Valius, Olli Gröhn, Vesa-Pekka Lehto
Drug carrier systems based on mesoporous inorganic nanoparticles generally face the problem of fast clearance from bloodstream thus failing in passive and active targeting to cancer tissue. To address this problem, a specific dual PEGylation (DPEG) method for mesoporous silicon (PSi) was developed and studied in vitro and in vivo. The DPEG coating changed significantly the behavior of the nanoparticles in vivo, increasing the circulation half-life from 1 to 241 min. Furthermore, accumulation of the coated particles was mainly taking place in the spleen whereas uncoated nanoparticles were rapidly deposited in the liver...
December 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27932583/inhibition-of-hiv-1-gag-membrane-interactions-by-specific-rnas
#2
Gabrielle C Todd, Alice A Duchon, Jingga Inlora, Erik D Olson, Karin Musier-Forsyth, Akira Ono
HIV-1 particle assembly, which occurs at the plasma membrane (PM) of cells, is driven by the viral polyprotein, Gag. Gag recognizes phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2], a PM-specific phospholipid, via the highly basic region (HBR) in its N-terminal matrix (MA) domain. The HBR is also known to bind to RNA. We have previously shown using an in vitro liposome binding assay that RNA inhibits Gag binding to membranes that lack PI(4,5)P2. If this RNA block is removed by RNase treatment, Gag can bind non-specifically to other negatively charged membranes...
December 8, 2016: RNA
https://www.readbyqxmd.com/read/27929406/a-thin-film-nanocomposite-membrane-with-mcm-41-silica-nanoparticles-for-brackish-water-purification
#3
Mohammed Kadhom, Jun Yin, Baolin Deng
Thin film nanocomposite (TFN) membranes containing MCM-41 silica nanoparticles (NPs) were synthesized by the interfacial polymerization (IP) process. An m-phenylenediamine (MPD) aqueous solution and an organic phase with trimesoyl chloride (TMC) dissolved in isooctane were used in the IP reaction, occurring on a nanoporous polysulfone (PSU) support layer. Isooctane was introduced as the organic solvent for TMC in this work due to its intermediate boiling point. MCM-41 silica NPs were loaded in MPD and TMC solutions in separate experiments, in a concentration range from 0 to 0...
December 6, 2016: Membranes
https://www.readbyqxmd.com/read/27923534/rapid-prototyped-patient-specific-guiding-implants-in-critical-mandibular-reconstruction
#4
Patricia Stoor, Anni Suomalainen, Karri Mesimäki, Risto Kontio
Large tumours of the mandible need immediate reconstruction to provide continuity of the mandible, satisfactory function of the jaw, as well as an acceptable aesthetic outcome. In this prospective study we described the immediate reconstruction of the mandible using computer aided design and 15 rapid prototyped patient specific implants (PSI) in 14 patients suffering from benign or malignant tumours demanding continuity resection of the mandible. The scaffold PSI was filled with β-tricalcium phosphate granules and autologous bone...
November 5, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27923401/effectiveness-of-the-who-safe-childbirth-checklist-program-in-reducing-severe-maternal-fetal-and-newborn-harm-in-uttar-pradesh-india-study-protocol-for-a-matched-pair-cluster-randomized-controlled-trial
#5
Katherine E A Semrau, Lisa R Hirschhorn, Bhala Kodkany, Jonathan M Spector, Danielle E Tuller, Gary King, Stuart Lipsitz, Narender Sharma, Vinay Pratap Singh, Bharath Kumar, Neelam Dhingra-Kumar, Rebecca Firestone, Vishwajeet Kumar, Atul A Gawande
BACKGROUND: Effective, scalable strategies to improve maternal, fetal, and newborn health and reduce preventable morbidity and mortality are urgently needed in low- and middle-income countries. Building on the successes of previous checklist-based programs, the World Health Organization (WHO) and partners led the development of the Safe Childbirth Checklist (SCC), a 28-item list of evidence-based practices linked with improved maternal and newborn outcomes. Pilot-testing of the Checklist in Southern India demonstrated dramatic improvements in adherence by health workers to essential childbirth-related practices (EBPs)...
December 7, 2016: Trials
https://www.readbyqxmd.com/read/27916634/lateral-heterogeneity-of-the-proton-potential-along-the-thylakoid-membranes-of-chloroplasts
#6
Alexey V Vershubskii, Boris V Trubitsin, Vladimir I Priklonskii, Alexander N Tikhonov
This work is devoted to critical analysis and reexamination of the problem of lateral heterogeneity of the trans-thylakoid pH difference (ΔpH=pHout-pHin) in thylakoid membranes of chloroplasts. Correct measurements of ΔpH may be complicated by nonuniform partitioning of the protons pumped into the lumen of granal (stacked) and stroma-exposed thylakoids. We have compared results of ΔpH estimations in isolated bean chloroplasts by two different methods. One of the methods is based on the use of pH-sensitive spin-probes...
December 1, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27915172/dark-chilling-induces-substantial-structural-changes-and-modifies-galactolipid-and-carotenoid-composition-during-chloroplast-biogenesis-in-cucumber-cucumis-sativus-l-cotyledons
#7
Joanna Skupień, Joanna Wójtowicz, Łucja Kowalewska, Radosław Mazur, Maciej Garstka, Katarzyna Gieczewska, Agnieszka Mostowska
Plants in a temperate climate are often subject to different environmental factors, chilling stress among them, which influence the growth especially during early stages of plant development. Chloroplasts are one of the first organelles affected by the chilling stress. Therefore the proper biogenesis of chloroplasts in early stages of plant growth is crucial for undertaking the photosynthetic activity. In this paper, the analysis of the cotyledon chloroplast biogenesis at different levels of plastid organization was performed in cucumber, one of the most popular chilling sensitive crops...
November 28, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27907935/a-meta-analysis-of-functional-outcomes-in-patient-specific-instrumented-knee-arthroplasty
#8
Ashim Mannan, Deji Akinyooye, Fahad Hossain
Alignment data in patient-specific instrumented (PSI) knee arthroplasty have been examined in several meta-analyses, with demonstration of comparative but not improved restitution of a neutral mechanical axis and favorable outcomes in femoral implant axial alignment. To date, no comprehensive synthesis of data has been conducted specifically for functional outcomes. Relevant databases were searched according to Preferred Reporting Items for Systematic reviews and Meta-analyses guidelines during the period 2000 to 2015 of Levels 1 and 2 studies comparing functional outcomes of patient-specific instrumentation (PSI) versus conventional instrumentation...
December 1, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27901131/porous-silicon-based-biosensors-towards-real-time-optical-detection-of-target-bacteria-in-the-food-industry
#9
Naama Massad-Ivanir, Giorgi Shtenberg, Nitzan Raz, Christel Gazenbeek, Dries Budding, Martine P Bos, Ester Segal
Rapid detection of target bacteria is crucial to provide a safe food supply and to prevent foodborne diseases. Herein, we present an optical biosensor for identification and quantification of Escherichia coli (E. coli, used as a model indicator bacteria species) in complex food industry process water. The biosensor is based on a nanostructured, oxidized porous silicon (PSi) thin film which is functionalized with specific antibodies against E. coli. The biosensors were exposed to water samples collected directly from process lines of fresh-cut produce and their reflectivity spectra were collected in real time...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27899649/protein-ontology-pro-enhancing-and-scaling-up-the-representation-of-protein-entities
#10
Darren A Natale, Cecilia N Arighi, Judith A Blake, Jonathan Bona, Chuming Chen, Sheng-Chih Chen, Karen R Christie, Julie Cowart, Peter D'Eustachio, Alexander D Diehl, Harold J Drabkin, William D Duncan, Hongzhan Huang, Jia Ren, Karen Ross, Alan Ruttenberg, Veronica Shamovsky, Barry Smith, Qinghua Wang, Jian Zhang, Abdelrahman El-Sayed, Cathy H Wu
The Protein Ontology (PRO; http://purl.obolibrary.org/obo/pr) formally defines and describes taxon-specific and taxon-neutral protein-related entities in three major areas: proteins related by evolution; proteins produced from a given gene; and protein-containing complexes. PRO thus serves as a tool for referencing protein entities at any level of specificity. To enhance this ability, and to facilitate the comparison of such entities described in different resources, we developed a standardized representation of proteoforms using UniProtKB as a sequence reference and PSI-MOD as a post-translational modification reference...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27898375/the-mediating-effects-of-cognitive-emotion-regulation-strategies-on-the-relationship-between-alexithymia-and-physical-symptoms-evidence-from-iranian-asthmatic-patients
#11
Fatemeh Ghorbani, Vahid Khosravani, Razieh Jamaati Ardakani, Amin Alvani, Hedayat Akbari
Asthma is a chronic and episodic psychosomatic disease whose symptoms include coughing, wheezing, chest tightness, and shortness of breath. The present study aimed to investigate the effects of cognitive emotion regulation strategies (CERS) as mediators on the relationships between alexithymia subscales and physical symptoms (PS). 300 asthmatic patients (males=42.7%, females=57.3%, age range=16-65, mean age=29.40) and 100 normal controls participated in the study and completed the demographic questionnaire, the Cognitive Emotion Regulation Questionnaire (CERQ), the Persian version of the Toronto Alexithymia Scale (FTAS-20), and the Powell & Enright Physical Symptoms Inventory (PSI)...
November 12, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27891603/using-harm-based-weights-for-the-ahrq-patient-safety-for-selected-indicators-composite-psi-90-does-it-affect-assessment-of-hospital-performance-and-financial-penalties-in-veterans-health-administration-hospitals
#12
Qi Chen, Amy K Rosen, Ann Borzecki, Michael Shwartz
OBJECTIVE: To assess whether hospital profiles for public reporting and pay-for-performance, measured by the Agency for Healthcare Research and Quality (AHRQ) Patient Safety for Selected Indicators (PSI-90) composite measure, were affected by using the recently developed harm-based weights. DATA SOURCES/STUDY SETTING: Retrospective analysis of 2012-2014 data from the Veterans Health Administration (VA). STUDY DESIGN: The AHRQ PSI software (v5...
December 2016: Health Services Research
https://www.readbyqxmd.com/read/27890156/physiological-and-perceptual-effects-of-a-cooling-garment-during-simulated-industrial-work-in-the-heat
#13
Cory L Butts, Cody R Smith, Matthew S Ganio, Brendon P McDermott
OBJECTIVE: Evaluate physiological and perceptual responses using a phase change cooling (PCC) garment during simulated work in the heat. METHODS: Twenty males wearing compression undergarments, coverall suit, gloves, and hard-hat, completed two randomly assigned trials (with PCC inserts or control, CON) of simulated industrial tasks in the heat (34.2 ± 0.05 °C, 54.7 ± 0.3%RH). Trials consisted of two 20 min work bouts, a maximum performance bout, and 10 min of recovery...
March 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/27889092/current-quality-measurement-tools-are-insufficient-to-assess-complications-in-orthopedic-surgery
#14
Arjun S Sebastian, Stephanie F Polites, Amy E Glasgow, Elizabeth B Habermann, Robert R Cima, Sanjeev Kakar
PURPOSE: The American College of Surgeons National Surgical Quality Improvement Project (ACS-NSQIP) is a clinically-derived, validated tool to track outcomes in surgery. The Agency for Healthcare Research and Quality Patient Safety Indicators (AHRQ-PSI) are a set of computer algorithms run on administrative data to identify adverse events. The purpose of this study is to compare complications following orthopedic surgery identified by ACS-NSQIP and AHRQ-PSI. METHODS: Patients between 2010 and 2012 who underwent orthopedic procedures (arthroplasty, spine, trauma, foot and ankle, hand, and upper extremity) at our tertiary-care, academic institution were identified (n = 3,374)...
November 23, 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27887875/two-stage-revision-for-infected-shoulder-arthroplasty
#15
Daniel B Buchalter, Siddharth A Mahure, Brent Mollon, Stephen Yu, Young W Kwon, Joseph D Zuckerman
BACKGROUND: Periprosthetic shoulder infections (PSIs) are challenging to treat and often result in significant patient morbidity. Without a standardized treatment protocol, PSIs are often managed similarly to periprosthetic hip and knee infections. Because 2-stage revision is the gold standard for treating periprosthetic hip and knee infections, we performed a case series and literature review to determine its effectiveness in PSIs. METHODS: We identified 19 patients (14 men) from our institution who were treated with a 2-stage revision after presenting with a PSI...
November 22, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27886066/importance-of-heat-and-pressure-for-solubilization-of-recombinant-spider-silk-proteins-in-aqueous-solution
#16
Justin A Jones, Thomas I Harris, Paula F Oliveira, Brianne E Bell, Abdulrahman Alhabib, Randolph V Lewis
The production of recombinant spider silk proteins continues to be a key area of interest for a number of research groups. Several key obstacles exist in their production as well as in their formulation into useable products. The original reported method to solubilize recombinant spider silk proteins (rSSp) in an aqueous solution involved using microwaves to quickly generate heat and pressure inside of a sealed vial containing rSSp and water. Fibers produced from this system are remarkable in their mechanical ability and demonstrate the ability to be stretched and recover 100 times...
November 23, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27885895/validity-and-reliability-of-the-very-short-form-of-the-physical-self-inventory-among-turkish-adolescents
#17
F Hülya Aşçi, Christophe Maïano, Alexandre J S Morin, Emine Çağlar, Naile Bilgili
The study aimed to test the validity and reliability of the Very Short form of the Physical Self-Inventory (PSI-VS) among a sample of 635 Turkish adolescents. These adolescents have completed the 12 original items of the PSI-VS, plus a positively worded reformulation of the single reverse-keyed item of the physical attractiveness subscale. A series of confirmatory factor analyses was used to examine the psychometric properties of the original and modified versions of the PSI-VS. Findings revealed superior psychometric properties with the modified version than with the original set of items...
November 25, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27884765/efficacy-of-clarithromycin-naproxen-oseltamivir-combination-in-the-treatment-of-patients-hospitalized-for-influenza-a-h3n2-infection-an-open-label-randomized-controlled-phase-2b-3-trial
#18
Ivan Fn Hung, Kelvin Kw To, Jasper Fw Chan, Vincent Cc Cheng, Kevin Sh Liu, Anthony Tam, Tuen-Ching Chan, Anna Jinxia Zhang, Patrick Li, Tin-Lun Wong, Ricky Zhang, Michael Ks Cheung, William Leung, Johnson Yn Lau, Manson Fok, Honglin Chen, Kwok-Hung Chan, Kwok-Yung Yuen
BACKGROUND: Influenza causes excessive hospitalizations and deaths. Single agent treatment with oseltamivir in severe influenza might be insufficient. The study assessed the efficacy and safety of oseltamivir-clarithromycin-naproxen combination for treatment of serious influenza. METHODS: From February to April 2015, we conducted a prospective open-label randomized-controlled trial. Adult patients hospitalized for A(H3N2) influenza were randomly assigned to a 2-day combination of clarithromycin 500mg, naproxen 200mg and oseltamivir 75mg twice daily, followed by 3 days of oseltamivir; or oseltamivir 75mg twice daily without placebos for 5 days as control (1:1)...
November 21, 2016: Chest
https://www.readbyqxmd.com/read/27882035/problem-solving-loneliness-depression-levels-and-associated-factors-in-high-school-adolescents
#19
Ummugulsum Sahin, Filiz Adana
OBJECTIVES: To determine problem solving, loneliness, depression levels and associated factors in high school adolescents. METHODS: This cross-sectional study was conducted in a city west of Turkey (Bursa) in a public high school and the population was 774 and the sampling was 394 students. Students to be included in the study were selected using the multiple sampling method. A personal Information Form with 23 questions, Problem Solving Inventory (PSI), Loneliness Scale (UCLA), Beck Depression Inventory (BDI) were used as data collection tools in the study...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27879572/importance-of-distal-fusion-level-in-major-thoracolumbar-and-lumbar-adolescent-idiopathic-scoliosis-treated-by-rod-derotation-and-direct-vertebral-rotation-following-pedicle-screw-instrumentation
#20
Dong-Gune Chang, Jae Hyuk Yang, Se-Il Suk, Seung-Woo Suh, Young-Hoon Kim, Woojin Cho, Yeon-Seok Jeong, Jin-Hyok Kim, Kee-Yong Ha, Jung-Hee Lee
STUDY DESIGN: A retrospective comparative study. OBJECTIVE: To analyze the exact distal fusion level in the treatment of major thoracolumbar and lumbar (TL/L) adolescent idiopathic scoliosis (AIS) using rod derotation (RD) and direct vertebral rotation (DVR) following pedicle screw instrumentation (PSI). SUMMARY OF BACKGROUND DATA: Proper determination of distal fusion level is a very important factor in deformity correction and preservation of motion segments in the treatment of major TL/L AIS...
November 22, 2016: Spine
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