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https://www.readbyqxmd.com/read/28092318/opening-injection-pressure-is-higher-in-intraneural-compared-with-perineural-injections-during-simulated-nerve-blocks-of-the-lower-limb-in-fresh-human-cadavers
#1
Kris Vermeylen, Marlies Hermans, Filiep Soetens, Evie Vereecke, Thorsten Steinfeldt, Gerbrand Groen, Admir Hadzic, Marc Van de Velde
BACKGROUND AND OBJECTIVES: Needle-induced nerve trauma and intraneural injection can lead to neurologic injury during peripheral nerve blocks. In this study, we assessed the utility of opening injection pressure (OIP), time to OIP, and rate of rise to OIP in detecting needle-nerve contact and intraneural injection. METHODS: Five common ultrasound-guided blocks of the femoral, saphenous, subgluteal sciatic, tibial, and common peroneal nerves were simulated in 10 fresh cadavers...
January 13, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28079681/internal-jugular-vein-compression-a-novel-approach-to-mitigate-blast-induced-hearing-injury
#2
Brian Sindelar, Michael Shinners, Sydney Sherman, Kevin Novak, Kristine Erickson, Vimal Patel, Paul Kubilis, David Smith, John Finan, Julian E Bailes
HYPOTHESIS: Internal jugular vein (IJV) compression before blast injury will lead to reduced risk of traumatic hearing injury following exposure to a blast injury. BACKGROUND: IJV compression and its effects on not only intracranial, but also intracochlear pressure may potentiate blast induced hearing injury, therefore, precluding its use as a prophylactic therapy for blast induced traumatic brain injury. METHODS: Twenty Sprague Dawley rats were exposed to a 17...
January 10, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28078528/reducing-stress-among-mothers-in-drug-treatment-a-description-of-a-mindfulness-based-parenting-intervention
#3
Vanessa L Short, Meghan Gannon, Wendy Weingarten, Karol Kaltenbach, Marianna LaNoue, Diane J Abatemarco
Background Parenting women with substance use disorder could potentially benefit from interventions designed to decrease stress and improve overall psychosocial health. In this study we assessed whether a mindfulness based parenting (MBP) intervention could be successful in decreasing general and parenting stress in a population of women who are in treatment for substance use disorder and who have infants or young children. Methods MBP participants (N = 59) attended a two-hour session once a week for 12 weeks...
January 11, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28077568/automatic-query-generation-using-word-embeddings-for-retrieving-passages-describing-experimental-methods
#4
Ferhat Aydın, Zehra Melce Hüsünbeyi, Arzucan Özgür
Information regarding the physical interactions among proteins is crucial, since protein-protein interactions (PPIs) are central for many biological processes. The experimental techniques used to verify PPIs are vital for characterizing and assessing the reliability of the identified PPIs. A lot of information about PPIs and the experimental methods are only available in the text of the scientific publications that report them. In this study, we approach the problem of identifying passages with experimental methods for physical interactions between proteins as an information retrieval search task...
2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28077004/endoplasmic-reticulum-stress-modulation-as-a-target-for-ameliorating-effects-of-blast-induced-traumatic-brain-injury
#5
Brandon Peter Lucke-Wold, Aric Logsdon, Ryan C Turner, Jason D Huber, Charles L Rosen
Blast traumatic brain injury (bTBI) has been shown to contribute to progressive neurodegenerative disease. Recent evidence suggests that endoplasmic reticulum (ER) stress is a mechanistic link between acute neurotrauma and progressive tauopathy. We propose that ER stress contributes to extensive behavioral changes associated with a CTE-like phenotype. Targeting ER stress is a promising option for the treatment of neurotrauma related neurodegeneration warranting investigation. Utilizing our validated and clinically relevant Sprague-Dawley blast model, we investigated a time course of mechanistic changes that occur following bTBI (50 PSI) including: ER stress activation, iron mediated toxicity, and tauopathy via western blot and immunohistochemistry...
January 11, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28073182/over-expression-of-the-molecular-chaperone-hsp104-in-saccharomyces-cerevisiae-results-in-the-malpartition-of-psi-propagons
#6
Frederique Ness, Brian S Cox, Jintana Wongwigkarn, Wesley R Naeimi, Mick F Tuite
The ability of a yeast cell to propagate [PSI(+) ], the prion form of the Sup35 protein, is dependent on the molecular chaperone Hsp104. Inhibition of Hsp104 function in yeast cells leads to a failure to generate new propagons, the molecular entities necessary for [PSI(+) ] propagation in dividing cells and they get diluted out as cells multiply. Over-expression of Hsp104 also leads to [PSI(+) ] prion loss and this has been assumed to arise from the complete disaggregation of the Sup35 prion polymers. However, in conditions of Hsp104 over-expression in [PSI(+) ] cells we find no release of monomers from Sup35 polymers, no monomerisation of aggregated Sup35 which is not accounted for by the proportion of prion-free [psi(-) ] cells present, no change in the molecular weight of Sup35-containing SDS-resistant polymers and no significant decrease in average propagon numbers in the population as a whole...
January 10, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28068517/rapid-analysis-of-drug-dissolution-by-paper-spray-ionization-mass-spectrometry
#7
Yang Liu, Ning Liu, Ya-Nan Zhou, Lan Lin, Lan He
With a great quantity of solid dosage tested by dissolution technology, developing a rapid and sensitive method to access the content of drug within dissolution media is highly desired by analysts and scientists. Traditionally, dissolution media is not compatible with mass spectrometry since the inorganic salts in the media might damage the mass spectrometer. Here, paper spray ionization mass spectrometry (PSI-MS), one of the ambient mass spectrometry technologies, is developed to characterize the content of drugs in dissolution media...
December 23, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28067617/role-of-protein-synthesis-and-dna-methylation-in-the-consolidation-and-maintenance-of-long-term-memory-in-aplysia
#8
Kaycey Pearce, Diancai Cai, Adam C Roberts, David L Glanzman
Previously, we reported that long-term memory (LTM) in Aplysia can be reinstated by truncated (partial) training following its disruption by reconsolidation blockade and inhibition of PKM (Chen et al., 2014). Here, we report thatLTM can be induced by partial training after disruption of original consolidation by protein synthesis inhibition (PSI) begun shortly after training. But when PSI occurs during training, partial training cannot subsequently establish LTM. Furthermore, we find that inhibition of DNA methyltransferase (DNMT), whether during training or shortly afterwards, blocks consolidation of LTM and prevents its subsequent induction by truncated training; moreover, later inhibition of DNMT eliminates consolidated LTM...
January 9, 2017: ELife
https://www.readbyqxmd.com/read/28064249/light-intensity-is-important-for-hydrogen-production-in-nahso3-treated-chlamydomonas-reinhardtii
#9
Lanzhen Wei, Jing Yi, Lianjun Wang, Tingting Huang, Fudan Gao, Quanxi Wang, Weimin Ma
Chlamydomonas reinhardtii is a unicellular green alga that can use light energy to produce H2 from H2O in the background of NaHSO3 treatment. However, the role of light intensity in such H2 production remains elusive. Here, light intensity significantly affected the yield of H2 production in NaHSO3-treated C. reinhardtii, which was consistent with its effects on the content of O2 and the expression and activity of hydrogenase. Further, NaHSO3 was found to be able to remove O2 via a reaction of bisulfite with superoxide anion produced at the acceptor side of PSI, and light intensity affected the reaction rate significantly...
January 7, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28063394/efficacy-of-psychological-pain-theory-based-cognitive-therapy-in-suicidal-patients-with-major-depressive-disorder-a-pilot-study
#10
Yingmin Zou, Huanhuan Li, Chuan Shi, Yixuan Lin, Hanyu Zhou, Jiaqi Zhang
The present study aimed to explore the effects of psychological pain theory-based cognitive therapy (PPTBCT) on suicide among depressed patients, compared with a control group who received usual psychological care (UPC). The sample consisted of 32 depressed patients and 32 healthy control subjects. All participants completed the Beck Scale for Suicide Ideation (BSI), Beck Depression Inventory, Three-Dimensional Psychological Pain Scale (TDPPS), and Problem Solving Inventory(PSI), and Automatic Thoughts Questionnaire (ATQ)...
December 31, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28063334/towards-interference-free-hplc-sers-for-the-trace-analysis-of-drug-metabolites-in-biological-fluids
#11
Waleed A Hassanain, Emad L Izake, Arumugam Sivanesan, Godwin A Ayoko
Sofosbuvir metabolite, 2'-deoxy-2'-fluoro-2'-C-methyluridine (PSI-6206) was studied for the first time by surface enhanced Raman spectroscopy (SERS) using the paper-based SERS substrate. The quantification limit of PSI-6206 by SERS was found to be 13ngL(-1) (R(2) value=0.959, RSD=5.23%). For the structural and quantitative analysis of PSI-6206 in blood plasma, an interference-free HPLC-SERS method was developed and compared to HPLC-DAD and HPLC-MS methods. The SERS quantification of the drug by the paper substrate was 4 orders of magnitude more sensitive than that by the diode array detector...
December 23, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28053097/subcellular-localization-of-hiv-1-gag-pol-mrnas-regulates-sites-of-virion-assembly
#12
Jordan T Becker, Nathan M Sherer
: HIV-1 full-length, unspliced RNAs serve dual roles in the cytoplasm as mRNAs encoding the Gag and Gag-Pol capsid proteins as well as genomic RNAs (gRNAs) packaged by Gag into virions undergoing assembly at the plasma membrane (PM). Because Gag is sufficient to drive assembly of virus-like particles even in the absence of gRNA binding, whether viral RNA trafficking plays an active role in the native assembly pathway is unknown. In this study we tested the effects of modulating the cytoplasmic abundance or distribution of full-length viral RNAs on Gag trafficking and assembly in the context of single cells...
January 4, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28048917/su-f-j-201-validation-study-of-proton-radiography-against-ct-data-for-quantitative-imaging-of-anatomical-changes-in-head-and-neck-patients
#13
A Hammi, D Weber, A Lomax
PURPOSE: In clinical pencil-beam-scanned (PBS) proton therapy, the advantage of the characteristic sharp dose fall-off after the Bragg Peak (BP) becomes a disadvantage if the BP positions of a plan's constituent pencil beams are shifted, eg.due to anatomical changes. Thus, for fractionated PBS proton therapy, accurate knowledge of the water equivalent path length (WEPL) of the traversed anatomy is critical. In this work we investigate the feasibility of using 2D proton range maps (proton radiography, PR) with the active-scanning gantry at PSI...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048801/su-f-t-39-comparing-nomograms-for-ordering-of-palladium-103-seeds-for-dynamic-intraoperative-prostate-seed-implantation
#14
P Taylor, L Wang, A Riegel
PURPOSE: Several nomograms exist for the purpose of ordering palladium- 103 seeds for permanent prostate seed implants. Excess seeds pose additional radiation safety risks and increase the cost of care. This study compared three seed ordering nomograms with seed counts from dynamic intra-operative PSI to determine (1) the cause of excess seeds and (2) the optimal nomogram for our institution. METHODS: Pre-operative and intra-operative clinical data were collected for 100 Gy (n=151) and 125 Gy (n=224) prostate seed implants...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046813/th-cd-209-07-preliminary-experimental-comparison-of-spot-and-continuous-line-scanning-with-or-without-rescanning-for-gated-proton-therapy
#15
G Fattori, G Klimpki, S Safai, D Weber, A Lomax, S Psoroulas
PURPOSE: We aim to compare the performance of discrete spot- or continuous line scanning combined with rescanning in mitigating residual organ motion during gated proton therapy treatments. METHODS: The Quasar respiratory phantom was used to move a 2D scintillation detector on a linear trajectory with sinusoidal motion pattern (sin(4) ), 20 mm peak-to-peak amplitude and 5 sec period. Its motion was monitored using a customized solution based on optical tracking technology...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039776/far-red-light-is-needed-for-efficient-photochemistry-and-photosynthesis
#16
Shuyang Zhen, Marc W van Iersel
The efficiency of monochromatic light to drive photosynthesis drops rapidly at wavelengths longer than 685nm. The photosynthetic efficiency of these longer wavelengths can be improved by adding shorter wavelength light, a phenomenon known as the Emerson enhancement effect. The reverse effect, the enhancement of photosynthesis under shorter wavelength light by longer wavelengths, however, has not been well studied and is often thought to be insignificant. We quantified the effect of adding far-red light (peak at 735nm) to red/blue or warm-white light on the photosynthetic efficiency of lettuce (Lactuca sativa)...
December 15, 2016: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28035761/analysis-of-swi-formation-and-propagation-events
#17
Zhiqiang Du, Dustin Kenneth Goncharoff, Xudong Cheng, Liming Li
The budding yeast, Saccharomyces cerevisiae, harbors several prions that are transmitted as altered, heritable protein conformations. [SWI(+) ] is one such prion whose determinant is Swi1, a subunit of the evolutionarily conserved chromatin-remodeling complex SWI/SNF. Despite the importance of Swi1, the molecular events that lead to [SWI(+) ] prionogenesis remain poorly understood. In this study, we have constructed floccullin-promoter-based URA3 reporters for [SWI(+) ] identification. Using these reporters, we show that the spontaneous formation frequency of [SWI(+) ] is significantly higher than that of [PSI(+) ] (prion form of Sup35)...
December 30, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/28034625/patient-specific-biodegradable-implant-in-pediatric-craniofacial-surgery
#18
H Essig, D Lindhorst, T Gander, P Schumann, D Könü, S Altermatt, M Rücker
Surgical correction of premature fusion of calvarial sutures involving the fronto-orbital region can be challenging due to the demanding three-dimensional (3D) anatomy. If fronto-orbital advancement (FOA) is necessary, surgery is typically performed using resorbable plates and screws that are bent manually intraoperatively. A new approach using individually manufactured resorbable implants (KLS Martin Group, Tuttlingen, Germany) is presented in the current paper. Preoperative CT scan data were processed in iPlan (ver...
November 30, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28034301/mechanistic-differences-between-hiv-1-and-siv-nucleocapsid-proteins-and-cross-species-hiv-1-genomic-rna-recognition
#19
Klara Post, Erik D Olson, M Nabuan Naufer, Robert J Gorelick, Ioulia Rouzina, Mark C Williams, Karin Musier-Forsyth, Judith G Levin
BACKGROUND: The nucleocapsid (NC) domain of HIV-1 Gag is responsible for specific recognition and packaging of genomic RNA (gRNA) into new viral particles. This occurs through specific interactions between the Gag NC domain and the Psi packaging signal in gRNA. In addition to this critical function, NC proteins are also nucleic acid (NA) chaperone proteins that facilitate NA rearrangements during reverse transcription. Although the interaction with Psi and chaperone activity of HIV-1 NC have been well characterized in vitro, little is known about simian immunodeficiency virus (SIV) NC...
December 29, 2016: Retrovirology
https://www.readbyqxmd.com/read/28032697/patient-specific-orthopaedic-implants
#20
REVIEW
Jack M Haglin, Adam E M Eltorai, Joseph A Gil, Stephen E Marcaccio, Juliana Botero-Hincapie, Alan H Daniels
Patient-specific orthopaedic implants are emerging as a clinically promising treatment option for a growing number of conditions to better match an individual's anatomy. Patient-specific implant (PSI) technology aims to reduce overall procedural costs, minimize surgical time, and maximize patient outcomes by achieving better biomechanical implant fit. With this commercially-available technology, computed tomography or magnetic resonance images can be used in conjunction with specialized computer programs to create preoperative patient-specific surgical plans and to develop custom cutting guides from 3-D reconstructed images of patient anatomy...
November 2016: Orthopaedic Surgery
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