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Raffaele Falsaperla, Andrea D Praticò, Martino Ruggieri, Enrico Parano, Renata Rizzo, Giovanni Corsello, Giovanna Vitaliti, Piero Pavone
Congenital muscular dystrophies (CMDs) are a wide group of muscular disorders that manifest with very early onset of muscular weakness, sometime associated to severe brain involvement.The histologic pattern of muscle anomalies is typical of dystrophic lesions but quite variable depending on the different stages and on the severity of the disorder.Recent classification of CMDs have been reported most of which based on the combination of clinical, biochemical, molecular and genetic findings, but genotype/phenotype correlation are in constant progression due to more diffuse utilization of the molecular analysis...
August 31, 2016: Italian Journal of Pediatrics
Enrico Parano, Xena Giada Pappalardo, Piero Pavone, Martino Ruggieri, Sebastiano Cavallaro
No abstract text is available yet for this article.
2016: Open Neurology Journal
Piero Pavone, Andrea D Praticò, Giovanna Vitaliti, Martino Ruggieri, Renata Rizzo, Enrico Parano, Lorenzo Pavone, Giuseppe Pero, Raffaele Falsaperla
The authors report a wide and updated revision of hydranencephaly, including a literature review, and present the case of a patient affected by this condition, still alive at 36 months.Hydranencephaly is an isolated and with a severe prognosis abnormality, affecting the cerebral mantle. In this condition, the cerebral hemispheres are completely or almost completely absent and are replaced by a membranous sac filled with cerebrospinal fluid. Midbrain is usually not involved. Hydranencephaly is a relatively rare cerebral disorder...
2014: Italian Journal of Pediatrics
P Pavone, V Rapisarda, A Serra, F Nicita, A Spalice, E Parano, R Rizzo, L Maiolino, P Di Mauro, G Vitaliti, A Coco, A Falsaperla, R R Trifiletti, S Cocuzza
Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS) is a well-defined syndrome in which tics (motor and/or vocal) and/or obsessive compulsive disorders (OCD) consistently exacerbate in temporal correlation to a Group A beta-haemolytic streptococcal infection. In children with PANDAS, there is speculation about whether tonsillectomy or adenotonsillectomy might improve the neuropsychiatric course. Our objective was to examine whether such surgery impacted remission or, in patients without remission, modified clinical course of the disease, streptococcal antibody titers, neuronal antibodies or clinical severity of Obsessive-Compulsive Disorder (OCD) and/or tics...
July 2014: International Journal of Immunopathology and Pharmacology
P Pavone, A Le Pira, F Greco, G Vitaliti, P L Smilari, E Parano, R Falsaperla
Three young patients with Bickerstaff's brainstem encephalitis (BBE) are reported. Some weeks following an upper tract infection, the children after a short period of recovery, showed acute onset of symmetric weakness of the lower limbs with difficulty in standing by and walking. The distal muscle weakness had a rapid progression with involvement of the cranial nerve, and then with severe impairment of the consciousness till to coma in one of the three children. BBE is a rare and often underdiagnosed affection in childhood...
2014: European Review for Medical and Pharmacological Sciences
Giovanna Vitaliti, Rosario R Trifiletti, Raffaele Falsaperla, Enrico Parano, Alberto Spalice, Piero Pavone
Until today there is a large debate about the existence of PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) or PANS (pediatric acute onset neuropsychiatric syndrome). These children usually have dramatic, "overnight" onset of symptoms, including motor or vocal tics, obsessions, and/or compulsions. In addition to these symptoms, children may also have comorbid features of associated disorders. Herein, we report a family with an early onset of tics, with exclusively dystonic and guttural tics...
January 2014: Journal of Pediatric Neurosciences
Vito Pavone, Andrea Domenico Praticò, Enrico Parano, Piero Pavone, Alberto Verrotti, Raffaele Falsaperla
No abstract text is available yet for this article.
November 2012: Clinical Neurology and Neurosurgery
Sonja Lj Paranos, Maja A Tomić, Ana M Micov, Radica M Stepanović-Petrović
Recent studies have shown that topiramate, a structurally novel anticonvulsant, exerts antinociceptive activity in animal models of neuropathic, acute somatic, and visceral pain. This study was aimed to examine: (i) the effects of systemically and locally peripherally administered topiramate in the rat inflammatory pain model and (ii) the potential role and site(s) of gamma-aminobutyric acid (GABA), opioid, and adrenergic receptors in topiramate's antihyperalgesia. Rats received intraplantar ( injections of the pro-inflammatory compound carrageenan...
June 2013: Fundamental & Clinical Pharmacology
P Pavone, M Pettoello-Mantovano, A Le Pira, I Giardino, A Pulvirenti, R Giugno, E Parano, A Polizzi, A Distefano, A Ferro, L Pavone, M Ruggieri
BACKGROUND: There are only a few series in the literature on acute disseminated encephalomyelitis (ADEM) in children. OBJECTIVES AND METHODS: the aims of this study were to perform (i) a prospective clinical/imaging study (1992-2009) on ADEM in children consecutively referred to our institution in Catania, Italy, and (ii) to undertake a systematic review and meta-analysis of published ADEM pediatric cohorts (>10 cases). RESULTS: We identified 17 patients with ADEM (incidence <10 years of age=1...
December 2010: Neuropediatrics
Marco Armando, Marco Bensi, Martina Brandizzi, Viviana Censi, Juliana Fortes Lindau, Paolo Fiori Nastro
INTRODUCTION: The aims of this study are (i) to assess the drop-out rate in an outpatient sample with mood disorder diagnosis in a psychotherapy unit; (ii) to focus clinical and sociodemographic variables related with drop-out; (iii) to delineate a psychopathological profile of the dropping-out patient through the SCL-90-R and OPD scores. METHOD: The sample of this study includes 90 depressive patients, which came to our service for a psychotherapy. The outcome is classified as drop-out and non drop-out...
November 2010: Rivista di Psichiatria
Keiko Kojo
The two concepts of Kontaktmangelparanoid (contact-deficit hallucinosis) and late paraphrenia at the level of symptomatology and psychopathology from the perspective of contributing to an understanding of these special problems of psychogeriatrics are discussed in the present study. This sheds light on the important role of isolation, especially in elderly females, as a pathogenic factor in late-onset paranoic state. Clinical physicians might naively associate late-onset paranoid (hallucinatory) syndrome with organic factors such as age and cerebrovascular processes, and particularly with dementia, but they do not associate it with the patient's living environment...
June 2010: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
Aaron L Mishara
Kafka's writings are frequently interpreted as representing the historical period of modernism in which he was writing. Little attention has been paid, however, to the possibility that his writings may reflect neural mechanisms in the processing of self during hypnagogic (i.e., between waking and sleep) states. Kafka suffered from dream-like, hypnagogic hallucinations during a sleep-deprived state while writing. This paper discusses reasons (phenomenological and neurobiological) why the self projects an imaginary double (autoscopy) in its spontaneous hallucinations and how Kafka's writings help to elucidate the underlying cognitive and neural mechanisms...
2010: Philosophy, Ethics, and Humanities in Medicine: PEHM
P Pavone, D A Mackey, E Parano, M Barbagallo, A D Praticò, R R Trifiletti
AIMS: We herein report a 5 years experience of management and care of children presenting blepharoptosis at the light of the literature regarding this uncommon pathology. This report aims to display the most common causes of blepharoptosis and its possible treatment. PATIENTS AND METHODS: Clinical and epidemiological data collected from our institution, over a fi ve year period, on 60 patients, 37 males and 23 females with a mean age of 5.4 years (range 0.6 to 15...
2010: La Clinica Terapeutica
R Falsaperla, E Parano, C Romano, A D Praticò, P Pavone
An increased level of serum creatine kinase has been considered as an indirect sign of muscular disorders but it may be an indicator of other diseases (malignant hyperthermia, tumors or endocrinopathy). Some patients present with a stationary clinical condition and absence of muscular symptoms, in whom the unique abnormality is hyperCKemia that is not associated with any biological or genetic diagnosis of MD. In others asymptomatic patients, an increase in CK may be a hematological marker that can predict muscular disease...
2010: La Clinica Terapeutica
M Brandizzi, S Fraietta, V Barbieri, G Cavaggioni
AIMS: The principal aim of this study is: (i) to assess the rate of depressive disorders in a sample of patient in a psychotherapy service of the Department of Psychiatric Sciences and Psychological Medicine at the Sapienza University, Roma; (ii) to focus the psychopathological features of depressive patient through the SCL-90R scale; (iii) to evaluate the correlation between SCL-90R score and categorical diagnosis. MATERIALS AND METHODS: The sample of this study includes 178 patients, who came to our service for a psychotherapy...
2010: La Clinica Terapeutica
P Pavone, R R Trifiletti, E Parano, M Fichera, M Ruggieri
We describe a mentally retarded 24-year-old man followed by our group since age 18 months who exhibited nearly continuous stereotypic movements while awake. These movements, which have persisted over many years, consist of synchronous lateral flexion at the neck and waist. Movements could be partially voluntarily suppressed and disappeared in sleep. The patient has drug-resistant seizures and a constellation of dysmorphic features, including coarse face, large nose, large thin lips, brachicephaly, marked hirsutism on the face, and limbs proportionally smaller than the trunk, which suggests that the unusual stereotypic movements described may be part of a syndrome...
August 2009: Neuropediatrics
Radica M Stepanovic-Petrovic, Maja A Tomic, Sonja M Vuckovic, Sonja Paranos, Nenad D Ugresic, Milica S Prostran, Slobodan Milovanovic, Bogdan Boskovic
BACKGROUND: There is evidence supporting the antinociceptive effects of carbamazepine, oxcarbazepine, gabapentin, and topiramate in various models of neuropathic pain as well as inflammatory somatic pain. Data are lacking on the antinociceptive potential of these drugs against visceral pain. In this study, we examined and compared the effects of carbamazepine, oxcarbazepine, gabapentin, and topiramate in the writhing test as a visceral pain model in the mouse. In addition, the influence of these anticonvulsants on motor performance was examined to compare the tolerability of these anticonvulsants when used against acute visceral pain...
June 2008: Anesthesia and Analgesia
I I Sergeev, S A Malinochka
Pathological hobbies have been studied in 82 inpatients with schizophrenia, 48 men and 34 women, aged 18-65 years. Inclusion criteria of pathology were (1) overvalued character of a hobby, (2) insufficient criticism towards this hobby, (3) fringe, singularity interests and methods of their realization; (4) inconsistency between the hobby and previous life experience, (5) low efficiency, (6) strong linkage with other psychopathological presentations, (7) chronological coincidence between the onset of pathological hobbies and schizophrenia manifestation or exacerbation, (8) susceptibility to progressive dynamics, (9) distinct social-maladaptive influence...
2008: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Martino Ruggieri, Gemma Incorpora, Agata Polizzi, Enrico Parano, Massimo Spina, Piero Pavone
OBJECTIVE: To determine the frequency of neurologic manifestations in children with gluten sensitivity (GS) and the frequency of GS in children with neurologic disease. STUDY DESIGN: A total of 835 children with GS (based on positive titers for serum anti-gliadin antibody [AGA], anti-endomysial antibody [EMA], and anti-tissue transglutamine [tTG] antibody and a positive gut biopsy), representing the local childhood GS population in the town of Catania, Italy, were recruited, prospectively followed up, and screened for neurologic and psychiatric disturbances between 1991 and 2004...
February 2008: Journal of Pediatrics
N Despotović, I Bojović, S Paranos, M Milovanović, V Dimitrović, T Rezić
UNLABELLED: The aim of our study is to show possible correlation between atopy and drug allergy, and the clinical manifestations of drug allergy that may have predictive value. There were 150 patients with positive history of drug allergy, ages 18-73 years. Cutaneous anr/or dose provocative testing was done, depending on the drug. Drug allergy was found in 58 patients (40%). There were 18 patients (12%) with atopic diathesis of which 9 (50%) were found to have drug allergy. Of 17 patients diagnosed as anaphylaxis, 13 (76%) had drug allergy, penicillin being the most common offending drug (7 parients)...
1994: Srpski Arhiv za Celokupno Lekarstvo
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