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Martin Horak, Kristina Holubova, Eugenie Nepovimova, Jan Krusek, Martina Kaniakova, Jan Korabecny, Ladislav Vyklicky, Kamil Kuca, Ales Stuchlik, Jan Ricny, Karel Vales, Ondrej Soukup
The mechanism of tacrine as a precognitive drug has been considered to be complex and not fully understood. It has been reported to involve a wide spectrum of targets involving cholinergic, gabaergic, nitrinergic and glutamatergic pathways. Here, we review the effect of tacrine and its derivatives on the NMDA receptors (NMDAR) with a focus on the mechanism of action and biological consequences related to the Alzheimer's disease treatment. Our findings indicate that effect of tacrine on glutamatergic neurons is both direct and indirect...
January 13, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
Rachel Natovich, Talma Kushnir, Ilana Harman-Boehm, Daniella Margalit, Itzhak Siev-Ner, Daniel Tsalichin, Ilia Volkov, Shmuel Giveon, Deborah Rubin-Asher, Tali Cukierman-Yaffe
OBJECTIVE: The presence of a foot ulcer increases the self-treatment burden imposed on the individual with diabetes. Additionally, this condition increases the cognitive demands needed for adherence to medical recommendations. A potential gap could exist between medical recommendations and the individual's ability to implement them. Hence, the goal of this study was to examine whether the cognitive profile of people with diabetic foot ulcers differs from that of people with diabetes without this complication...
July 2016: Diabetes Care
Ina M Tarkka, Andrej Savić, Elina Pekkola, Mirva Rottensteiner, Tuija Leskinen, Jaakko Kaprio, Urho M Kujala
Leisure-time physical activity is a key contributor to physical and mental health. Yet the role of physical activity in modulating cortical function is poorly known. We investigated whether precognitive sensory brain functions are associated with the level of physical activity. Physical activity history (3-yr-LTMET), physiological measures and somatosensory mismatch response (sMMR) in EEG were recorded in 32 young healthy twins. In all participants, 3-yr-LTMET correlated negatively with body fat%, r=-0.77 and positively with VO2max, r=0...
May 2016: Biological Psychology
Beatrice Bortolato, Kamilla W Miskowiak, Cristiano A Köhler, Michael Maes, Brisa S Fernandes, Michael Berk, André F Carvalho
BACKGROUND: Cognitive dysfunction in major depressive disorder (MDD) encompasses several domains, including but not limited to executive function, verbal memory, and attention. Furthermore, cognitive dysfunction is a frequent residual manifestation in depression and may persist during the remitted phase. Cognitive deficits may also impede functional recovery, including workforce performance, in patients with MDD. The overarching aims of this opinion article are to critically evaluate the effects of available antidepressants as well as novel therapeutic targets on neurocognitive dysfunction in MDD...
January 22, 2016: BMC Medicine
Debajyoti Pati, Michael O'Boyle, Jiancheng Hou, Upali Nanda, Hessam Ghamari
OBJECTIVE: To examine whether exposure to curve versus sharp contours in the built healthcare setting produces systematic and identifiable patterns of amygdala activation and behavioral response in healthy adults. BACKGROUND: Recent studies in cognitive neuroscience suggest that humans prefer objects with a curved contour compared with objects that have pointed features and a sharp-angled contour. An implicit perception of threat represented by sharp objects, in humans, was hypothesized to explain this bias...
April 2016: HERD
Petr P Nikolaev, Galina I Rozhkova
In the last series of papers published during 1975 to 1980, Alfred Yarbus tried to formulate general conceptions concerning the basic principles of retinal image processing in the human visual system. The original ideas of Yarbus were based on the results of his numerous and various experiments carried out with extraordinary inventiveness and great skill. Being concentrated primarily on the problems of color vision, Alfred Yarbus dreamed of elaborating a comprehensive model that would simulate visual information processing at the monocular precognitive level in the visual system of humans with normal trichromatic color perception...
2015: Perception
Giuseppe Scimeca, Antonio Bruno, Gianluca Pandolfo, Giulia La Ciura, Rocco A Zoccali, Maria R A Muscatello
This study investigated whether people who report recurrent extrasensory perception (ESP) experiences (telepathy, clairvoyance, and precognition) have suffered more traumatic experiences and traumatic intrusions. Thirty-one nonclinical participants reporting recurrent ESP experiences were compared with a nonclinical sample of 31 individuals who did not report recurrent ESP phenomena. Past traumatic experiences were assessed via a self-report measure of trauma history (Childhood Trauma Questionnaire); traumatic intrusions were assessed via a performance-based personality measure (Rorschach Traumatic Content Index)...
November 2015: Journal of Nervous and Mental Disease
Marieke Jepma, Tor D Wager
Classical conditioning can profoundly modify subsequent pain responses, but the mechanisms that drive this effect are unresolved. In pain-conditioning studies, cues are typically conditioned to primary aversive reinforcers; hence, subsequent pain modulation could reflect learned precognitive associations (i.e., those involving neural plasticity independent of expectations and other forms of conceptual thought) or conceptual expectancies. We isolated conceptual contributions using a thermal pain-conditioning procedure in which different conditioned stimulus (CS) cues were repeatedly paired with symbolic representations of high and low noxious heat...
November 2015: Psychological Science
Tomoharu Yoshiya, Yoshihiro Miyata, Yuta Ibuki, Takahiro Mimae, Yasuhiro Tsutani, Haruhiko Nakayama, Sakae Okumura, Masahiro Yoshimura, Morihito Okada
BACKGROUND: Findings on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) are surrogate markers of malignancy in lung adenocarcinoma. Breathing during PET/CT can substantially reduce the maximum standardized uptake value (maxSUV) of lung tumors when they are located at the lower zone (LZ). OBJECTIVES: We assessed whether lung cancer location influences the malignancy predicted by maxSUV. METHODS: 608 patients with clinical stage IA lung adenocarcinoma had been preoperatively examined by PET/CT and high-resolution computed tomography (HRCT)...
2015: Respiration; International Review of Thoracic Diseases
Glenn A M Hitchman, Simon J Sherwood, Chris A Roe
CONTEXT: Many spontaneous cases of extra-sensory perception (ESP) seem to occur without the conscious intent of the experient to manifest any anomalous phenomena. Indeed, Stanford׳s psi-mediated instrumental response (PMIR) theory, which frames ESP as a goal-oriented function, goes as far as to suggest that such intent may be counterproductive to psi. OBJECTIVES: The present study was the latest to build on the successful paradigm developed by Luke and colleagues in testing the non-intentional psi hypothesis and potential covariates of psi task success...
March 2015: Explore: the Journal of Science and Healing
A E Bobrov, L A Krasnoslobodtseva, E M Mutnykh, A A Kursakov
The characteristics of cognitive impairment in depression are reviewed. Data of literature indicate that cognitive impairment may serve as a predictor of depression recurrence and poor prognosis of antidepressant therapy. In this view, we consider the importance of assessment of cognitive impairment and differential use of medications with precognitive effect (bupropion, vorteoxetine and some SSRI antidepressants as well as fluvoxamine, which is a potent agonist of the sigma-1-receptor).
2014: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Michael S Franklin, Stephen L Baumgart, Jonathan W Schooler
No abstract text is available yet for this article.
2014: Frontiers in Psychology
Katy Price
Using letters sent to British playwright J. B. Priestley in 1963, this paper explores the intersection between patient-focused history of psychiatry and the history of parapsychology in everyday life. Priestley's study of precognition lay outside the main currents of parapsychology, and his status as a storyteller encouraged confidences about anomalous temporal experience and mental illness. Drawing on virtue epistemology, I explore the regulation of subjectivity operated by Priestley in establishing the credibility of his correspondents in relation to their gender and mental health, and investigate the possibility of testimonial justice for these witnesses...
December 2014: Studies in History and Philosophy of Biological and Biomedical Sciences
Milan Valášek, Caroline Watt, Jenny Hutton, Rebecca Neill, Rachel Nuttall, Grace Renwick
Seemingly precognitive (prophetic) dreams may be a result of one's unconscious processing of environmental cues and having an implicit inference based on these cues manifest itself in one's dreams. We present two studies exploring this implicit processing hypothesis of precognitive dream experience. Study 1 investigated the relationship between implicit learning, transliminality, and precognitive dream belief and experience. Participants completed the Serial Reaction Time task and several questionnaires. We predicted a positive relationship between the variables...
August 2014: Consciousness and Cognition
Ernesto Bonilla
Every day new scientific information is appearing that cannot be explained using the classical Newtonian model and is calling for the emergence of a new paradigm that would include the explanation of such phenomena as telepathy, clairvoyance, presentiment, precognition, out of the body experiences, psychic healing, after-death communication, near-death experiences and reincarnation. The materialist paradigm which considers the brain as the sole cause of consciousness and psychic phenomena has been challenged by a new paradigm that seems to demonstrate that there is not a cause-effect relationship between brain activity and psychic phenomena but only a correlation between them, since these phenomena can be experienced without the body and appear to have an extra-cerebral origin (cosmic field, cosmic consciousness?)...
June 2014: Investigación Clínica
Karin Landolt, Amrei Wittwer, Thomas Wyss, Lui Unterassner, Wolfgang Fach, Peter Krummenacher, Peter Brugger, Helene Haker, Wolfram Kawohl, Pius August Schubiger, Gerd Folkers, Wulf Rössler
BACKGROUND: Exceptional experiences (EE) are experiences that deviate from ordinary experiences, for example precognition, supernatural appearances, or déjà vues. In spite of the high frequency of EE in the general population, little is known about their effect on mental health and about the way people cope with EE. This study aimed to assess the quality and quantity of EE in persons from the Swiss general population, to identify the predictors of their help-seeking, and to determine how many of them approach the mental health system...
2014: Frontiers in Public Health
R Bouvet, H Djeriouat, N Goutaudier, J Py, H Chabrol
INTRODUCTION: For the last decades, many researchers have focused on paranormal beliefs. Beliefs in the existence of paranormal phenomena would be common and studies conducted in westernized countries have highlighted a high prevalence of individuals believing in the existence of such phenomena. Tobacyk and Milford (1984) developed the Revised Paranormal Belief Scale (RPBS) for assessing beliefs in paranormal phenomena. This 26-item self-reported questionnaire, measuring beliefs in phenomena such as witchcraft or superstition, is one of the most widely used questionnaires to assess such beliefs...
September 2014: L'Encéphale
Julia A Mossbridge, Patrizio Tressoldi, Jessica Utts, John A Ives, Dean Radin, Wayne B Jonas
A recent meta-analysis of experiments from seven independent laboratories (n = 26) indicates that the human body can apparently detect randomly delivered stimuli occurring 1-10 s in the future (Mossbridge etal., 2012). The key observation in these studies is that human physiology appears to be able to distinguish between unpredictable dichotomous future stimuli, such as emotional vs. neutral images or sound vs. silence. This phenomenon has been called presentiment (as in "feeling the future"). In this paper we call it predictive anticipatory activity (PAA)...
2014: Frontiers in Human Neuroscience
Vedat Sar, Firdevs Alioğlu, Gamze Akyüz
This study sought to determine the prevalence of experiences of possession and paranormal phenomena (PNP) in the general population and their possible relations to each other and to traumatic stress and dissociation. The study was conducted on a representative female sample recruited from a town in central eastern Turkey. The Dissociative Disorders Interview Schedule, the posttraumatic stress disorder (PTSD) and borderline personality disorder sections of the Structured Clinical Interviews for DSM-IV Axis-I and Personality Disorders, and the Childhood Abuse and Neglect Questionnaire were administered to 628 women...
2014: Journal of Trauma & Dissociation
Katarzyna Jankowska, Anna Delewska, Robert Klimkiewicz, Anna Kubsik, Marta Woldańska-Okońska
Methods of the transdermal administration of drugs have long been sought in the medical field in order to ensure the noninvasive and painless transmission of the medicine. Such methods include the TTS (transdermal therapeutic system). It is a method, or rather a set of methods that allows the introduction of the drug to the sites of pathologically changed areas without the pharmacological burdening of the whole body. An important aspect of this treatment is that the substance can be introduced passively (even to unconscious or sanity-limited patients) or actively, i...
September 2013: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
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