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https://www.readbyqxmd.com/read/29675363/clinical-and-imaging-features-of-pituitary-apoplexy-and-role-of-imaging-in-differentiation-of-clinical-mimics
#1
REVIEW
Pradeep Goyal, Michael Utz, Nishant Gupta, Yogesh Kumar, Manisha Mangla, Sonali Gupta, Rajiv Mangla
To discuss the clinical syndrome, review common imaging findings of pituitary apoplexy (PA) and role of imaging in therapy and follow-up. Also, to review other acute clinical scenarios with similar clinical and/or imaging findings as PA. PA is a severe and potentially life-threatening medical emergency, characterized by constellation of symptoms/signs that occur as a result of acute hemorrhage and/or infarction in pituitary gland. Patients present with acute and sudden onset of symptoms/signs, most commonly with severe headache, vision deficits/ophthalmoplegia, altered mental status, and possible pan hypopituitarism...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29666945/carbonic-anhydrase-9-expression-in-well-differentiated-pancreatic-neuroendocrine-neoplasms-might-be-associated-with-aggressive-behavior-and-poor-survival
#2
Joo Young Kim, Sang Hwa Lee, Soyeon An, Sung Joo Kim, You-Na Sung, Ki-Byung Song, Dae Wook Hwang, Song Cheol Kim, Seung-Mo Hong
Well-differentiated pancreatic neuroendocrine neoplasms/tumors (PanNETs) are rare neoplasms with diverse clinical behavior. Biomarker discovery is important for predicting clinical course and prognosis of PanNET patients. Carbonic anhydrase 9 (CA9) and vimentin are hypoxia and epithelial-mesenchymal transition-related proteins of which expression in many carcinomas has been associated with poor prognosis, but their significance in PanNET has yet to be determined. We assessed CA9 and vimentin expression in 164 PanNETs and compared this with clinicopathologic characteristics...
April 18, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29665752/histopathologic-findings-in-canine-pituitary-glands
#3
Margaret A Miller, David S Bruyette, J Catharine Scott-Moncrieff, Tina Jo Owen, José A Ramos-Vara, Hsin-Yi Weng, Andrea L Vanderpool, Annie V Chen, Linda G Martin, Deidre M DuSold, Sina Jahan
To optimize the histologic evaluation of hypophysectomy specimens, sections of 207 canine pituitary glands (196 postmortem, 11 hypophysectomy specimens) were reviewed. Adenohypophyseal proliferation was the most common (n = 79) lesion. Proliferative lesions were sparsely to densely granulated; the granules were usually basophilic to chromophobic and periodic acid-Schiff-positive. Adenohypophyseal proliferation was classified as hyperplasia (n = 40) if ≤2 mm diameter with intact reticulin network, as microadenoma (n = 22) for 1-5 mm homogeneous nodules with lost reticulin network, or as macroadenoma (n = 17) for larger tumors...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29581739/investigating-the-application-of-diving-endoscopic-technique-in-determining-the-extent-of-pituitary-adenoma-resection-via-the-trans-nasal-sphenoidal-approach
#4
Hai-Bin Gao, Li-Qing Wang, Jian-Yun Zhou, Wei Sun
The aim of the present study was to investigate the advantages and disadvantages of the diving endoscopic technique in pituitary adenoma surgery, and the application value in determining the extent of tumor resection. A total of 37 patients with pituitary adenoma initially underwent tumor resection under an endoscope-assisted microscope via standard trans-nasal-sphenoidal approach, and tumor cavity structure was observed by applying the diving endoscopic technique. Surgery was subsequently performed again under a microscope or endoscope...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29580720/endonasal-endoscopic-surgery-in-pituitary-adenomas-surgical-results-in-a-series-of-86-consecutive-patients
#5
R López-García, J Abarca-Olivas, I Monjas-Cánovas, A M Picó Alfonso, P Moreno-López, J R Gras-Albert
INTRODUCTION: The endoscopic endonasal approach has become the gold standard for the surgical treatment of pituitary adenomas. OBJECTIVES: The aim of this study is to present the results obtained in our hospital in purely endoscopic surgery of pituitary adenomas. METHODS: From February 2011 to August 2016, we conducted a prospective study on a series of 86 patients with pituitary adenoma, all of whom underwent surgery with a purely endoscopic endonasal approach...
March 23, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29570013/value-of-pituitary-gland-mri-at-7-t-in-cushing-s-disease-and-relationship-to-inferior-petrosal-sinus-sampling-case-report
#6
Meng Law, Regina Wang, Chia-Shang J Liu, Mark S Shiroishi, John D Carmichael, William J Mack, Martin Weiss, Danny J J Wang, Arthur W Toga, Gabriel Zada
Cushing's disease is caused by adrenocorticotrophic hormone (ACTH)-secreting pituitary adenomas, which are often difficult to identify on standard 1.5-T or 3-T MRI, including dynamic contrast imaging. Inferior petrosal and cavernous sinus sampling remains the gold standard for MRI-negative Cushing's disease. The authors report on a 27-year-old woman with Cushing's disease in whom the results of standard 1.5-T and 3-T MRI, including 1.5-T dynamic contrast imaging, were negative. Inferior petrosal sinus sampling showed a high central-to-peripheral ACTH ratio (148:1) as well as a right-to-left ACTH gradient (19:1), suggesting a right-sided pituitary microadenoma...
March 23, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29532430/complete-evaluation-of-pituitary-tumours-in-a-single-tertiary-care-institution
#7
Dimitrios Askitis, Damianos Tsitlakidis, Nicolle Müller, Albrecht Waschke, Gunter Wolf, Ulrich Alfons Müller, Christof Kloos
INTRODUCTION: We retrospectively evaluated all patients with pituitary tumours treated in our department from 1/1/1997 to 01/11/2014. PATIENTS AND METHODS: Two hundred and fifteen patients (124 females, 91 males, mean age 50.9 years) were treated because of pituitary tumours. All patients underwent basal hormonal analysis and when required dynamic testing in order to check for hormonal activity. Pituitary masses were divided into groups concerning their hormonal status and were further classified according to gender, age at diagnosis, tumour size, and the development of postoperative pituitary insufficiency when neurosurgical intervention was conducted...
March 12, 2018: Endocrine
https://www.readbyqxmd.com/read/29501516/plurihormonal-acth-gh-pituitary-adenoma-case-report-and-systematic-literature-review
#8
Elena Roca, Pier Paolo Mattogno, Teresa Porcelli, Luigi Poliani, Francesco Belotti, Alberto Schreiber, Filippo Maffezzoni, Marco Maria Fontanella, Francesco Doglietto
INTRODUCTION: Plurihormonal adenomas (PHA) represent 10-15% of all functioning pituitary adenomas. The most frequent hormonal association is represented by prolactin and growth hormone (GH). AIM: To describe a rare case of functional ACTH and GH microadenoma, together with a systematic literature review on PHA. METHODS: PubMed was searched using the terms "plurihormonal pituitary adenoma", "ACTH, GH pituitary adenoma", and "Acromegaly AND Cushing's disease"...
February 28, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29394965/frequency-of-macroprolactin-in-hyperprolactinemia
#9
Noreen Abbas Sherazi, Mirza Zain Baig, Aysha Habib Khan
OBJECTIVE: To determine the frequency of Macroprolactin (MaPRL) in patients with increased total prolactin and its clinical and financial impact. STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Section of Clinical Chemistry, Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi, from March to May 2015. METHODOLOGY: Patients with high total prolactin were screened by polyethylene glycol (PEG) precipitation for determination of MaPRL...
February 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29370344/carcinogenic-response-and-other-histopathological-alterations-in-mice-exposed-to-cigarette-smoke-for-varying-time-periods-after-birth
#10
Roumen Balansky, Gancho Ganchev, Marietta Iltcheva, Emilia Dimitrova, Rosanna T Micale, Sebastiano La Maestra, Silvio De Flora
In spite of the outstanding role of tobacco smoking in human carcinogenesis, it is difficult to reproduce its effects in experimental animals. Based on the knowledge that a variety of mechanisms account for a higher susceptibility to carcinogens early in life, we have developed a murine model in which mainstream cigarette smoke becomes convincingly carcinogenic. The standard model involves exposure to smoke for 4 months, starting after birth, followed by an additional 3-4 months in filtered air. We evaluated herein the time- and dose-dependent response, at 7...
January 23, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29335487/increased-expression-of-glp-1r-in-proliferating-islets-of-men1-mice-is-detectable-by-68-ga-ga-do3a-vs-cys-40-exendin-4-pet
#11
Azita Monazzam, Joey Lau, Irina Velikyan, Su-Chen Li, Masoud Razmara, Ulrika Rosenström, Olof Eriksson, Britt Skogseid
Multiple endocrine neoplasia type 1 (MEN1) is an endocrine tumor syndrome caused by heterozygous mutations in the MEN1 tumor suppressor gene. The MEN1 pancreas of the adolescent gene carrier frequently contain diffusely spread pre-neoplasias and microadenomas, progressing to macroscopic and potentially malignant pancreatic neuroendocrine tumors (P-NET), which represents the major death cause in MEN1. The unveiling of the molecular mechanism of P-NET which is not currently understood fully to allow the optimization of diagnostics and treatment...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29280025/management-of-nonfunctioning-pituitary-adenomas-nfas-observation
#12
REVIEW
Wenyu Huang, Mark E Molitch
Clinically nonfunctioning pituitary adenomas (NFAs) range from those causing significant hypothalamic/pituitary dysfunction and visual field compromise due to their large size to those being completely asymptomatic. In the absence of hypersecretion, hypopituitarism or visual field defects, patients with NFAs may be followed by periodic surveillance using MRI to detect tumor enlargement. In some cases, endocrine tests are also needed during observation to discover new pituitary dysfunction. Enlargement of NFAs without treatment occurs in about 10% of microadenomas and 23% of macroadenomas...
April 2018: Pituitary
https://www.readbyqxmd.com/read/29238923/endoscopic-therapy-and-curative-effect-in-pituitary-adenoma-patients-complicated-by-acromegalic-cardiomyopathy
#13
Heping Zhou, Zhengjiang Zha, Xiangdong Li, Xinsheng Chen, Jing Wang, Zhongzhou Su
The study aimed to retrospectively analyze the clinical characteristics of patients with pituitary adenomas complicated by acromegalic cardiomyopathy and to evaluate the effect of endoscopic surgery. Eighty-six pituitary adenoma patients complicated by acromegalic cardiomyopathy who were treated with endoscopic surgery in the First Affiliated Hospital of Soochow University from January 2010 to December 2016 were enrolled. We noted patient clinical characteristics and explored the relationships with surgical treatment...
December 13, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29232342/intraoperative-near-infrared-fluorescence-imaging-of-multiple-pancreatic-neuroendocrine-tumors-a-case-report
#14
Henricus J M Handgraaf, Leonora S F Boogerd, Shirin Shahbazi Feshtali, Arantza Fariña Sarasqueta, Marieke Snel, Rutger-Jan Swijnenburg, Alexander L Vahrmeijer, Bert A Bonsing, J Sven D Mieog
Multiple endocrine neoplasia type 1 syndrome can feature pancreatic neuroendocrine lesions that have the potential to degenerate into malignancies (pancreatic neuroendocrine tumors [PNETs]). Resection is required in selected cases and aims to cure patients and to prevent metastasis. Preoperative imaging is important to assess the number, size, and location of PNETs. However, sensitivity of preoperative imaging modalities to detect small lesions can be rather disappointing. This makes intraoperative reassessment of the pancreas crucial...
January 2018: Pancreas
https://www.readbyqxmd.com/read/29168011/pediatric-prolactinoma-initial-presentation-treatment-and-long-term-prognosis
#15
Anika Hoffmann, Sarah Adelmann, Kristin Lohle, Alexander Claviez, Hermann L Müller
Prolactinoma is a rare pituitary adenoma secreting prolactin. Studies on diagnostics, treatment, and prognosis in pediatric prolactinoma patients are rare. We analyzed clinical presentation, response to treatment, and prognosis of 27 pediatric prolactinoma patients (10 m/17 f. based on patients' records. Tumors included 6 microadenomas (tumor volume: median 0.2 cm3 , range 0.01-0.4 cm3 ; serum prolactin at diagnosis: median 101 ng/ml, range 33-177 ng/ml), 15 macroadenomas (volume: median 3.3 cm3 , range 0...
January 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29156752/early-and-late-effects-of-aspirin-and-naproxen-on-micrornas-in-the-lung-and-blood-of-mice-either-unexposed-or-exposed-to-cigarette-smoke
#16
Alberto Izzotti, Roumen Balansky, Gancho Ganchev, Marietta Iltcheva, Mariagrazia Longobardi, Alessandra Pulliero, Anna Camoirano, Francesco D'Agostini, Marta Geretto, Rosanna T Micale, Sebastiano La Maestra, Mark Steven Miller, Vernon E Steele, Silvio De Flora
We recently showed that nonsteroidal anti-inflammatory drugs (NSAIDs) are able to inhibit the lung tumors induced by cigarette smoke, either mainstream (MCS) or environmental (ECS), in female mice. We used subsets of mice to analyze the expression of 1135 microRNAs in both lung and blood serum, as related to the whole-body exposure to smoke and/or oral administration of either aspirin or naproxen. In a first study, we evaluated early microRNA alterations in A/J mice exposed to ECS for 10 weeks, starting at birth, and/or treated with NSAIDs for 6 weeks, starting after weaning...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29122850/differential-preventive-activity-of-sulindac-and-atorvastatin-in-apc-min-fcccmice-with-or-without-colorectal-adenomas
#17
Wen-Chi L Chang, Christina Jackson, Stacy Riel, Harry S Cooper, Karthik Devarajan, Harvey H Hensley, Yan Zhou, Lisa A Vanderveer, Minhhuyen T Nguyen, Margie L Clapper
OBJECTIVE: The response of subjects to preventive intervention is heterogeneous. The goal of this study was to determine if the efficacy of a chemopreventive agent differs in non-tumour-bearing animals versus those with colorectal tumours. Sulindac and/or atorvastatin was administered to Apc+/Min-FCCC mice with known tumour-bearing status at treatment initiation. DESIGN: Male mice (6-8 weeks old) underwent colonoscopy and received control chow or chow with sulindac (300 ppm), atorvastatin (100 ppm) or sulindac/atorvastatin...
November 9, 2017: Gut
https://www.readbyqxmd.com/read/29113856/has-acromegaly-been-diagnosed-earlier
#18
Hideko Ohno, Yuichiro Yoneoka, Shinya Jinguji, Naoto Watanabe, Masayasu Okada, Yukihiko Fujii
PURPOSE: We investigated whether acromegaly has been diagnosed earlier at the Niigata Medical and Dental University Hospital. METHODS: Patients with acromegaly (n = 81) who underwent their first transsphenoidal surgery from 2006 to 2015 were reviewed. Two groups were compared: those who underwent surgery between 2006 and 2010 (n = 35) and those who underwent surgery between 2011 and 2015 (n = 46). We compared clinical features and serum levels of the growth hormone (GH) and insulin-like growth factor-1 (IGF-1), hypertension (HT) and diabetes mellitus (DM) prevalence between the two groups...
February 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29092962/multiple-endocrine-neoplasia-type-1-presenting-with-refractory-seizures
#19
Banshi Lal Kumawat, Chandramohan Sharma, Mohit Janakkumar Shah, Maulik Panchal
We report a case of 29-year-old woman referred to us for management of refractory epilepsy. Under observation, she was detected to have recurrent hypoglycaemia during the episodes of seizures. On investigation, she was found to have hyperinsulinemic hypoglycaemia. Her triple-phase CT scan of abdomen showed neuroendocrine tumour of pancreatic head, with bilateral renal calculi. Screening of other endocrine glands revealed pituitary microadenoma and parathyroid adenoma on imaging, which was also supported by biochemical and hormonal profile...
November 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29066490/novel-germline-p-gly42val-men1-mutation-in-a-family-with-multiple-endocrine-neoplasia-type-1-excellent-response-of-prolactinoma-to-cabergoline
#20
Viktoria F Koehler, Kerstin Jungheim, Ute Groß, Donato Iacovazzo, Alexander Mann, Márta Korbonits
We report on a 27-year-old male patient presenting with renal colic secondary to hyperparathyroidism. Further investigations confirmed a diagnosis of type 1 multiple endocrine neoplasia and revealed a 2.0 cm pancreatic neuroendocrine tumour as well as a pituitary macroadenoma with significantly elevated prolactin levels. The patient underwent three-gland parathyroidectomy, a left pancreatectomy, and received dopamine agonist treatment. Genetic testing revealed a novel germline heterozygote missense mutation in the MEN1 gene (p...
September 2017: Annals of Clinical and Laboratory Science
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