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https://www.readbyqxmd.com/read/29394965/frequency-of-macroprolactin-in-hyperprolactinemia
#1
Noreen Abbas Sherazi, Mirza Zain Baig, Aysha Habib Khan
OBJECTIVE: To determine the frequency of Macroprolactin (MaPRL) in patients with increased total prolactin and its clinical and financial impact. STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Section of Clinical Chemistry, Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi, from March to May 2015. METHODOLOGY: Patients with high total prolactin were screened by polyethylene glycol (PEG) precipitation for determination of MaPRL...
February 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29370344/carcinogenic-response-and-other-histopathological-alterations-in-mice-exposed-to-cigarette-smoke-for-varying-time-periods-after-birth
#2
Roumen Balansky, Gancho Ganchev, Marietta Iltcheva, Emilia Dimitrova, Rosanna T Micale, Sebastiano La Maestra, Silvio De Flora
In spite of the outstanding role of tobacco smoking in human carcinogenesis, it is difficult to reproduce its effects in experimental animals. Based on the knowledge that a variety of mechanisms account for a higher susceptibility to carcinogens early in life, we have developed a murine model in which mainstream cigarette smoke becomes convincingly carcinogenic. The standard model involves exposure to smoke for 4 months, starting after birth, followed by an additional 3-4 months in filtered air. We evaluated herein the time- and dose-dependent response, at 7...
January 23, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29335487/increased-expression-of-glp-1r-in-proliferating-islets-of-men1-mice-is-detectable-by-68ga-ga-do3a-vs-cys40-exendin-4-pet
#3
Azita Monazzam, Joey Lau, Irina Velikyan, Su-Chen Li, Masoud Razmara, Ulrika Rosenström, Olof Eriksson, Britt Skogseid
Multiple endocrine neoplasia type 1 (MEN1) is an endocrine tumor syndrome caused by heterozygous mutations in the MEN1 tumor suppressor gene. The MEN1 pancreas of the adolescent gene carrier frequently contain diffusely spread pre-neoplasias and microadenomas, progressing to macroscopic and potentially malignant pancreatic neuroendocrine tumors (P-NET), which represents the major death cause in MEN1. The unveiling of the molecular mechanism of P-NET which is not currently understood fully to allow the optimization of diagnostics and treatment...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29280025/management-of-nonfunctioning-pituitary-adenomas-nfas-observation
#4
REVIEW
Wenyu Huang, Mark E Molitch
Clinically nonfunctioning pituitary adenomas (NFAs) range from those causing significant hypothalamic/pituitary dysfunction and visual field compromise due to their large size to those being completely asymptomatic. In the absence of hypersecretion, hypopituitarism or visual field defects, patients with NFAs may be followed by periodic surveillance using MRI to detect tumor enlargement. In some cases, endocrine tests are also needed during observation to discover new pituitary dysfunction. Enlargement of NFAs without treatment occurs in about 10% of microadenomas and 23% of macroadenomas...
December 26, 2017: Pituitary
https://www.readbyqxmd.com/read/29238923/endoscopic-therapy-and-curative-effect-in-pituitary-adenoma-patients-complicated-by-acromegalic-cardiomyopathy
#5
Heping Zhou, Zhengjiang Zha, Xiangdong Li, Xinsheng Chen, Jing Wang, Zhongzhou Su
The study aimed to retrospectively analyze the clinical characteristics of patients with pituitary adenomas complicated by acromegalic cardiomyopathy and to evaluate the effect of endoscopic surgery. Eighty-six pituitary adenoma patients complicated by acromegalic cardiomyopathy who were treated with endoscopic surgery in the First Affiliated Hospital of Soochow University from January 2010 to December 2016 were enrolled. We noted patient clinical characteristics and explored the relationships with surgical treatment...
December 13, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29232342/intraoperative-near-infrared-fluorescence-imaging-of-multiple-pancreatic-neuroendocrine-tumors-a-case-report
#6
Henricus J M Handgraaf, Leonora S F Boogerd, Shirin Shahbazi Feshtali, Arantza Fariña Sarasqueta, Marieke Snel, Rutger-Jan Swijnenburg, Alexander L Vahrmeijer, Bert A Bonsing, J Sven D Mieog
Multiple endocrine neoplasia type 1 syndrome can feature pancreatic neuroendocrine lesions that have the potential to degenerate into malignancies (pancreatic neuroendocrine tumors [PNETs]). Resection is required in selected cases and aims to cure patients and to prevent metastasis. Preoperative imaging is important to assess the number, size, and location of PNETs. However, sensitivity of preoperative imaging modalities to detect small lesions can be rather disappointing. This makes intraoperative reassessment of the pancreas crucial...
January 2018: Pancreas
https://www.readbyqxmd.com/read/29168011/pediatric-prolactinoma-initial-presentation-treatment-and-long-term-prognosis
#7
Anika Hoffmann, Sarah Adelmann, Kristin Lohle, Alexander Claviez, Hermann L Müller
Prolactinoma is a rare pituitary adenoma secreting prolactin. Studies on diagnostics, treatment, and prognosis in pediatric prolactinoma patients are rare. We analyzed clinical presentation, response to treatment, and prognosis of 27 pediatric prolactinoma patients (10 m/17 f. based on patients' records. Tumors included 6 microadenomas (tumor volume: median 0.2 cm 3 , range 0.01-0.4 cm 3 ; serum prolactin at diagnosis: median 101 ng/ml, range 33-177 ng/ml), 15 macroadenomas (volume: median 3.3 cm 3 , range 0...
January 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29156752/early-and-late-effects-of-aspirin-and-naproxen-on-micrornas-in-the-lung-and-blood-of-mice-either-unexposed-or-exposed-to-cigarette-smoke
#8
Alberto Izzotti, Roumen Balansky, Gancho Ganchev, Marietta Iltcheva, Mariagrazia Longobardi, Alessandra Pulliero, Anna Camoirano, Francesco D'Agostini, Marta Geretto, Rosanna T Micale, Sebastiano La Maestra, Mark Steven Miller, Vernon E Steele, Silvio De Flora
We recently showed that nonsteroidal anti-inflammatory drugs (NSAIDs) are able to inhibit the lung tumors induced by cigarette smoke, either mainstream (MCS) or environmental (ECS), in female mice. We used subsets of mice to analyze the expression of 1135 microRNAs in both lung and blood serum, as related to the whole-body exposure to smoke and/or oral administration of either aspirin or naproxen. In a first study, we evaluated early microRNA alterations in A/J mice exposed to ECS for 10 weeks, starting at birth, and/or treated with NSAIDs for 6 weeks, starting after weaning...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29122850/differential-preventive-activity-of-sulindac-and-atorvastatin-in-apc-min-fcccmice-with-or-without-colorectal-adenomas
#9
Wen-Chi L Chang, Christina Jackson, Stacy Riel, Harry S Cooper, Karthik Devarajan, Harvey H Hensley, Yan Zhou, Lisa A Vanderveer, Minhhuyen T Nguyen, Margie L Clapper
OBJECTIVE: The response of subjects to preventive intervention is heterogeneous. The goal of this study was to determine if the efficacy of a chemopreventive agent differs in non-tumour-bearing animals versus those with colorectal tumours. Sulindac and/or atorvastatin was administered to Apc+/Min-FCCC mice with known tumour-bearing status at treatment initiation. DESIGN: Male mice (6-8 weeks old) underwent colonoscopy and received control chow or chow with sulindac (300 ppm), atorvastatin (100 ppm) or sulindac/atorvastatin...
November 9, 2017: Gut
https://www.readbyqxmd.com/read/29113856/has-acromegaly-been-diagnosed-earlier
#10
Hideko Ohno, Yuichiro Yoneoka, Shinya Jinguji, Naoto Watanabe, Masayasu Okada, Yukihiko Fujii
PURPOSE: We investigated whether acromegaly has been diagnosed earlier at the Niigata Medical and Dental University Hospital. METHODS: Patients with acromegaly (n = 81) who underwent their first transsphenoidal surgery from 2006 to 2015 were reviewed. Two groups were compared: those who underwent surgery between 2006 and 2010 (n = 35) and those who underwent surgery between 2011 and 2015 (n = 46). We compared clinical features and serum levels of the growth hormone (GH) and insulin-like growth factor-1 (IGF-1), hypertension (HT) and diabetes mellitus (DM) prevalence between the two groups...
November 4, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29092962/multiple-endocrine-neoplasia-type-1-presenting-with-refractory-seizures
#11
Banshi Lal Kumawat, Chandramohan Sharma, Mohit Janakkumar Shah, Maulik Panchal
We report a case of 29-year-old woman referred to us for management of refractory epilepsy. Under observation, she was detected to have recurrent hypoglycaemia during the episodes of seizures. On investigation, she was found to have hyperinsulinemic hypoglycaemia. Her triple-phase CT scan of abdomen showed neuroendocrine tumour of pancreatic head, with bilateral renal calculi. Screening of other endocrine glands revealed pituitary microadenoma and parathyroid adenoma on imaging, which was also supported by biochemical and hormonal profile...
November 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29066490/novel-germline-p-gly42val-men1-mutation-in-a-family-with-multiple-endocrine-neoplasia-type-1-excellent-response-of-prolactinoma-to-cabergoline
#12
Viktoria F Koehler, Kerstin Jungheim, Ute Groß, Donato Iacovazzo, Alexander Mann, Márta Korbonits
We report on a 27-year-old male patient presenting with renal colic secondary to hyperparathyroidism. Further investigations confirmed a diagnosis of type 1 multiple endocrine neoplasia and revealed a 2.0 cm pancreatic neuroendocrine tumour as well as a pituitary macroadenoma with significantly elevated prolactin levels. The patient underwent three-gland parathyroidectomy, a left pancreatectomy, and received dopamine agonist treatment. Genetic testing revealed a novel germline heterozygote missense mutation in the MEN1 gene (p...
September 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29031329/dogs-with-macroadenomas-have-lower-body-temperature-and-heart-rate-than-dogs-with-microadenomas
#13
Ghita Benchekroun, Loic Desquilbet, Michael E Herrtage, Nick D Jeffery, Dan Rosenberg, Nicolas Granger
Pituitary macroadenomas compress the hypothalamus, which partly regulates heart rate and body temperature. The aim of this study was to investigate whether heart rate and/or body temperature could aid in clinically differentiating dogs with macroadenomas from dogs with microadenomas (i.e. small non-compressive pituitary mass). Two groups of dogs diagnosed with pituitary-dependent hyperadrenocorticism (i.e. Cushing's disease) were included. Heart rate and body temperature were collected on initial presentation before any procedure...
September 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29027863/potential-utility-of-flair-in-mri-negative-cushing-s-disease
#14
Grégoire P Chatain, Nicholas Patronas, James G Smirniotopoulos, Martin Piazza, Sarah Benzo, Abhik Ray-Chaudhury, Susmeeta Sharma, Maya Lodish, Lynnette Nieman, Constantine A Stratakis, Prashant Chittiboina
OBJECTIVE Accurate presurgical localization of microadenomas in Cushing's disease (CD) leads to improved remission rates and decreased adverse events. Volumetric gradient recalled echo (3D-GRE) MRI detects pituitary microadenomas in CD in up to 50%-80% cases as a focus of hypointensity due to delayed contrast wash-in. The authors have previously reported that postcontrast FLAIR imaging may be useful in detecting otherwise MRI-negative pituitary microadenomas as foci of hyperintensity. This reflects theoretically complementary imaging of microadenomas due to delayed contrast washout...
October 13, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29025207/a-rare-case-of-multiple-pituitary-adenomas-in-an-adolescent-cushing-disease-presenting-as-a-vertebral-compression-fracture
#15
Ji-Yeon Song, Sue-Jean Mun, Soon-Ki Sung, Jae-Yeon Hwang, Seung-Kug Baik, Jee Yeon Kim, Chong-Kun Cheon, Su-Young Kim, Yoo-Mi Kim
Cushing disease in children and adolescents, especially with multiple pituitary adenomas (MPAs), is very rare. We report 17-year-old boy with MPAs. He presented with a vertebral compression fracture, weight gain, short stature, headache, and hypertension. On magnetic resonance imaging (MRI), only a left pituitary microadenoma was found. After surgery, transient clinical improvement was observed but headache and hypertension were observed again after 3 months later. Follow-up MRI showed a newly developed right pituitary microadenoma 6 months after the surgery...
September 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29022276/diagnosis-and-treatment-of-tsh-secreting-adenomas-review-of-a-longtime-experience-in-a-reference-center
#16
D M Nazato, J Abucham
PURPOSE: TSH-secreting pituitary adenomas are among the less prevalent pituitary tumors, corresponding to 0.9-1.5% of all pituitary adenomas in surgical series. METHODS: A series of 11 patients with TSH-secreting and cosecreting adenomas diagnosed and treated in the last 25 years in a single center is described. RESULTS: The mean age at diagnosis was 37 years (range 18-80 years; median 23 years); the ratio of male-to-female patients was similar (6M:5F)...
October 11, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28986303/corticotropin-releasing-hormone-can-selectively-stimulate-glucose-uptake-in-corticotropinoma-via-glucose-transporter-1
#17
Jie Lu, Blake K Montgomery, Grégoire P Chatain, Alejandro Bugarini, Qi Zhang, Xiang Wang, Nancy A Edwards, Abhik Ray-Chaudhury, Marsha J Merrill, Russell R Lonser, Prashant Chittiboina
BACKGROUND: Pre-operative detection of corticotropin (ACTH) secreting microadenomas causing Cushing's disease (CD) improves surgical outcomes. Current best magnetic resonance imaging fails to detect up to 40% of these microadenomas. 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) is specific, but not sensitive in detecting corticotropinomas. Theoretically, secretagogue stimulation with corticotropin releasing hormone (CRH) could improve detection of adenomas with 18F-FDG PET...
October 3, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28977166/long-term-follow-up-of-patients-with-elevated-igf-1-and-nadir-gh-0-4-%C3%A2%C2%B5g-l-but-1-%C3%A2%C2%B5g-l
#18
Pedro Weslley Rosario, Maria Regina Calsolari
OBJECTIVE: To report the results of initial investigation and after 5 years of patients with a suspicious clinical scenario for acromegaly, elevated IGF-1, and nadir GH during an oral glucose tolerance test (OGTT) > 0.4 µg/L but < 1 µg/L. SUBJECTS AND METHODS: Seventeen patients who had elevated IGF-1 (outside puberty and pregnancy) in two measurements and GH between 0.4 and 1 µg/L during OGTT were selected. RESULTS: During initial assessment, only one patient had microadenoma on magnetic resonance imaging (MRI) of the pituitary...
2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28954743/morbidity-and-mortality-in-patients-with-hyperprolactinaemia-the-prolears-study
#19
Enrique Soto-Pedre, Paul J Newey, John S Bevan, Graham P Leese
PURPOSE: High serum prolactin concentrations have been associated with adverse health outcomes in some but not all studies. This study aimed to examine the morbidity and all-cause mortality associated with hyperprolactinaemia. METHODS: A population-based matched cohort study in Tayside (Scotland, UK) from 1988 to 2014 was performed. Record-linkage technology was used to identify patients with hyperprolactinaemia that were compared to an age-sex-matched cohort of patients free of hyperprolactinaemia...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28951275/diagnosis-and-outcomes-of-341-patients-with-cushing-s-disease-following-transsphenoid-surgery-a-single-center-experience
#20
Ming Feng, Ziyuan Liu, Xiaohai Liu, Xinjie Bao, Yong Yao, Kan Deng, Bing Xing, Wei Lian, Huijuan Zhu, Lin Lu, Renzhi Wang
BACKGROUND: Transsphenoid surgery (TSS) is a standard treatment modality for Cushing's disease (CD). However, postoperative remission and recurrence rates vary among studies. Here we analyze the diagnosis and outcomes of 341 patients with a preoperative diagnosis of CD undergoing TSS in a single center over a 3-year period. METHODS: A total of 341 patients were enrolled. Clinical manifestations, imaging results, laboratory workups, and results of inferior petrosal sinus sampling (IPSS) were obtained...
September 23, 2017: World Neurosurgery
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