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rectosigmoid adenocarcinoma

Filippo Banchini, Roberta Santoni, Antonio Banchini, Flavio Cesare Bodini, Patrizio Capelli
INTRODUCTION: Posterior right diaphragmatic hernia is rare in newborn patients but when present, is accompanied by high mortality. Pulmonary hypoplasia seems to be the main cause of death but the presence of liver involvement remains one of the reasons for poor prognosis even when intrauterine surgery is performed. CASE DESCRIPTION: In this article, we will present a rare case that was diagnosed by chance in a 65-year old adult presenting with an adenocarcinoma of the rectosigmoid junction and a right Bochdalek hernia with liver herniation and modification of the hepatic vein outflow with a natural right to left shunt...
2016: SpringerPlus
Anjali D Amarapurkar, Prachi Nichat, Nitin Narawane, Deepak Amarapurkar
INTRODUCTION: Incidence of colorectal carcinoma is increasing all over world. There is limited data on colorectal polyps from India. We evaluated the histomorphological features of colorectal polyps and determined risk stratification in adenomatous polyps. METHODS: In 4970 consecutive colonoscopies, colorectal polyps were detected in 515 cases (10.3 %). Polyps were classified using standard histological criteria. Each polyp was evaluated for presence of dysplasia...
July 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
Yimin Dong, Hitendra Patel, Charmi Patel
Intrabiliary metastasis from colorectal carcinoma (CRC) growing within or invading bile ducts is not a very common pattern. However, accurate diagnosis of metastatic lesions is very important for selection of adjuvant therapy and prognosis. We report a case of 71-year-old male who developed painless jaundice due to hepatobiliary obstruction. MRI demonstrated 1.4 cm intraductal mass at hepatic hilum with severe intrahepatic ductal dilation, consistent with cholangiocarcinoma. ERCP (endoscopic retrograde cholangiopancreatography) showed intraductal segmental biliary stricture...
2016: Case Reports in Pathology
Shintaro Shiba, Masaru Wakatsuki, Shingo Kato, Tatsuya Ohno, Noriyuki Okonogi, Kumiko Karasawa, Hiroki Kiyohara, Hirohiko Tsujii, Takashi Nakano, Tadashi Kamada, Makio Shozu
The purpose of this study was to evaluate the efficacy and toxicities of carbon-ion radiotherapy (C-ion RT) for locally advanced cervical cancer with bladder invasion by a subset analysis of pooled data from eight prospective clinical trials at the National Institute of Radiological Sciences. Between June 1995 and January 2014, 29 patients with locally advanced cervical cancer with bladder invasion were identified. The median age was 56 years old (range 31-79 years old). The median tumor size at diagnosis on magnetic resonance imaging was 6...
July 15, 2016: Journal of Radiation Research
Mina Alvandipour, Mohammad Yasin Karami, Mehdi Khalvati, Hamed Khodabakhsh
The authors report the case of a 63-year-old man who underwent an open adrenalectomy for a synchronous, malignant, metastatic left adrenal tumor and a total colectomy for T3N0M1 (stage 4) primary, malignant colon cancer. Two polypoid lesions, one measuring 40 mm × 30 mm × 30 mm and the other measuring 20 mm × 10 mm × 10 mm, were found in the ascending colon and rectosigmoid (RS) junction, respectively, and a synchronous, malignant, left adrenal gland lesion measuring 70 mm × 50 mm × 30 mm was incidentally found on abdominal computed tomography scan...
April 2016: Annals of Coloproctology
Erik Staffa, Vladan Bernard, Luboš Kubíček, Robert Vlachovský, Daniel Vlk, Vojtěch Mornstein, Robert Staffa
Foot complications in persons with diabetes mellitus (DM) are associated with substantial costs and loss of quality of life. Increasing evidence suggests changes in skin temperature, measured using an infrared thermographic system (IRT), may be a predictor of foot ulcer development in patients with DM. The purpose of this case study is to describe the long-term IRT findings and overall clinical outcomes of a patient with DM and peripheral vascular disease. Foot temperature measurements using IRT were obtained slightly more than 1 year before and immediately following endovascular treatment of a 76-year-old man, a nonsmoker with type 2 DM, hypertension, and ischemic heart disease with cardiac arrhythmia...
April 2016: Ostomy/wound Management
Seyed Mehdi Hashemi, Seyed Amirhossein Fazeli, Fatemeh Arabpour-Dahouei, Ali Davarian, Reza Golabchifard
We herein report a case of colonic polyposis, colorectal carcinoma and large B-cell lymphoma in a 22-year-old male patient with a previous history of childhood lymphoblastic lymphoma. Eight years after lymphoblastic lymphoma, which presented as mediastinal mass and superior vena cava syndrome, the patient complained of abdominal pain, lower gastrointestinal bleeding and an abdominal mass. The surgical exploration revealed numerous mucosal polyps throughout the large intestine, and multifocal masses in the ascending and transverse colon and the rectosigmoid region...
March 2016: Molecular and Clinical Oncology
María Dolores Pérez Valderas, Óscar Nogales Rincón, Javier García Lledó, Leticia Pérez Carazo, Beatriz Merino Rodríguez, Ignacio Marín Jiménez, Cecilia González Asanza, Pedro Menchén Fernández-Pacheco
No abstract text is available yet for this article.
February 2016: Revista Española de Enfermedades Digestivas
Masahisa Ohtsuka, Taishi Hata, Masayuki Hiraki, Hiroshi Takeyama, Ryoji Nonaka, Mamoru Uemura, Junichi Nishimura, Ichiro Takemasa, Tsunekazu Mizushima, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori
The patient was a 72-year-old man. Colonoscopy revealed a circumferential villous tumor with granular aggregates extending from the rectosigmoid (RS) to the lower rectum (Rb). Although most portions were indicative of a villous adenoma, a reddish coarse region at the upper rectum (Ra) was diagnosed as a concurrent adenocarcinoma based on biopsies. Consequently, we performed laparoscopy-assisted intersphincteric resection (ISR) and D3 lymph node dissection. Pathological diagnosis revealed multiple lymph node (LN) metastases, including ones at the root of the inferior mesenteric artery (IMA)...
June 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Tianzuo Zhan, Felix Hahn, Thomas Hielscher, Johannes Betge, Georg Kähler, Matthias P Ebert, Sebastian Belle
BACKGROUND: Large colonic polyps are associated with advanced dysplasia, but prevalence and characteristics of synchronous polyps in patients with large flat colonic polyps are poorly investigated. This study aims to characterize clinicopathological features of large flat colonic polyps and their impact on occurrence and characteristics of synchronous polyps. METHODS: A total of 802 patients that underwent endoscopic mucosal resection (EMR) of flat colonic polyps >20 mm from 2003 to 2014 in an academic endoscopy unit were retrospectively analyzed for size, location and histology of large polyps and synchronous polyps...
2015: BMC Gastroenterology
Kobe Van Bael, Yanina Jansen, Teofila Seremet, Benedikt Engels, Georges Delvaux, Bart Neyns
A 43-year-old women admitted to our hospital for weight loss, anorexia, and abdominal pain was diagnosed with sigmoid neoplasm and multiple bilobar liver metastases. This patient received six cycles of systemic FOLFOX prior to a laparoscopically assisted anterior resection of the rectosigmoid for a poorly differentiated invasive adenocarcinoma T2N2M1, K-RAS negative (wild type). Hepatic arterial infusion (HAI) of L-folinic acid modulated 5-fluorouracil (LV/5-FU) with intravenous (iv) irinotecan (FOLFIRI) and cetuximab as adjuvant therapy resulted in a complete metabolic response (CR) with CEA normalization...
2015: Case Reports in Oncological Medicine
Leticia P Luz, Gregory A Cote, Mohammad A Al-Haddad, Lee McHenry, Julia K LeBlanc, Stuart Sherman, Daniel M Moreira, Ihab I El Hajj, Kathleen McGreevy, John DeWitt
BACKGROUND: The utility of endoscopic ultrasound (EUS) compared with standard white light endoscopy (WLE) following recent polypectomy of high-risk colorectal polyps is unknown. OBJECTIVE: To assess the incremental yield of EUS after endoscopic polypectomy of a high-risk rectal lesion. DESIGN: Retrospective cohort. SETTING: Tertiary referral center. MATERIALS AND METHODS: Patients referred for EUS following attempted endoscopic resection of a high-risk rectal neoplasm, defined as a tubulovillous adenoma, tubular adenoma with high-grade dysplasia, carcinoid, carcinoma in-situ or adenocarcinoma (CA)...
April 2015: Endoscopic Ultrasound
Aaron Lim, Benjamin Grant, John Avramovic, Yik-Hong Ho, Corrine Wallace
Synchronous primary anorectal melanoma and colorectal adenocarcinoma is extremely rare, with only 5 cases reported in the literature. Here, a case is reported and the currently available literature is summarized. A 72-year-old white male presented with changes in his bowel habits and unintentional weight loss. Colonoscopy revealed a polypoid mass in the distal rectum extending to the anal verge anteriorly and a circumferential polypoid mass in the distal sigmoid colon. Biopsies were taken, which revealed poorly differentiated melanoma of the anorectal mass and moderately differentiated adenocarcinoma of the sigmoid mass with nodal involvement...
May 2015: International Surgery
Ehsan Khodapasand, Narges Jafarzadeh, Farid Farrokhi, Behnam Kamalidehghan, Massoud Houshmand
BACKGROUND: Bax and Bcl-2 are the major members of Bcl-2 family whose play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction. Therefore, the balance between pro- and anti-apoptotic members of this family can determine the cellular fate. METHODS: In this study, the relative level of mRNA expression of Bax and Bcl-2 genes was determined using RNA extraction, cDNA synthesis and RT-qPCR technique from 22 tumoral tissues and adjacent non-tumoral tissues from adenocarcinoma colorectal cancer...
2015: Iranian Biomedical Journal
John P Keating, Stephanie Manning, Elizabeth Dennett, Rod Studd
BACKGROUND: This study aims to define the clinical and oncological outcome of 'en-bloc' excision of the seminal vesicles for locally advanced and recurrent tumours of the sigmoid and rectum. METHODS: Eight patients were identified from a prospective colorectal cancer database at a tertiary centre as having undergone excision of the seminal vesicles in continuity with a locally advanced or recurrent sigmoid or rectal adenocarcinoma. The presentation, operative details, histopathology, oncological outcome and morbidity of the procedure were assessed...
April 1, 2015: ANZ Journal of Surgery
Ayako Watanabe, Ryo Inada, Takeshi Nagasaka, Tomohiko Yagi, Hijiri Matsumoto, Toshiaki Toshima, Yoshiko Mori, Yoshitaka Kondo, Hiroyuki Kishimoto, Toshiyoshi Fujiwara
A man in his 50s underwent high anterior resection for rectosigmoid cancer in January 2010. The primary tumor was diagnosed as a moderately differentiated adenocarcinoma with KRAS mutation, pStage III a. In May 2011, the patient had a recurrent lung tumor detected by computed tomography(CT); the tumor was resected using video-assisted thoracoscopic surgery. However, additional recurrent lung tumors arose, and radiofrequency ablation (RFA) was performed to treat these in February 2012. After RFA therapy, capecitabine was administered as adjuvant chemotherapy...
February 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Minoru Kobayashi, Shinobu Ohnuma, Shunsuke Kato, Hideaki Karasawa, Takeshi Aoki, Katsuyoshi Kudo, Naoki Tanaka, Kazuhiro Watanabe, Munenori Nagao, Tomoya Abe, Hiroaki Musha, Takanori Morikawa, Fuyuhiko Motoi, Yu Katayose, Takeshi Naito, Michiaki Unno
A-39-year-old man presented to a nearby clinic owing to long-term diarrhea and painful defecation. He was diagnosed with a well-differentiated tubular adenocarcinoma of the rectosigmoid and underwent a laparotomy at another hospital. At surgery, the tumor was seen to deeply invade into the urinary bladder with the presence of intra-abdominal abscess. Loop sigmoid colostomy was performed due to possible invasion into the pelvic wall and peritoneal dissemination. The patient was referred to the our hospital for systemic chemotherapy...
November 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Florin Zaharie, George Ciorogar, Roxana Zaharie, Marcel Tantau, Cornel Iancu, Lucian Mocan
The mean age of colorectal cancer in untreated familial adenomatous polyposis (FAP) is 39 years. We present the case of a 21-year-old patient with FAP and colorectal cancer. The patient was detected with significant family history: her mother died at age 45 with colon cancer; two uncles were diagnosed with colon cancer at the age of 40 and 43 and one aunt at the age of 45 with colon cancer and gastric cancer. The treatment was laparoscopic restorative proctocolectomy with total excision of the mesorectum and ileal pouch anal anastomosis completed with endoanal excision of inferior rectal polyps...
December 2014: Journal of Gastrointestinal and Liver Diseases: JGLD
Sang Woo Lim, Hyeong Rok Kim, Young Jin Kim
PURPOSE: The aim of this retrospective study was to evaluate the feasibility of single incision laparoscopic surgery (SILS), and to compare the short-term surgical outcomes with those of conventional laparoscopic surgery for colorectal cancer. METHODS: Forty-four patients who underwent SILS were compared with 263 patients who underwent conventional laparoscopic surgery for colorectal adenocarcinoma between November 2011 and September 2012. RESULTS: In the SILS group, eleven cases (25...
September 2014: Annals of Surgical Treatment and Research
Ethan B Ludmir, Shannon J McCall, Brian G Czito, Manisha Palta
An 82-year-old man presented with progressive right frontal headaches. The patient's history was significant for benign polyps on surveillance colonoscopy 2 years prior, without high-grade dysplasia or carcinoma. MRI revealed an enhancing lesion arising within the superomedial aspect of the right orbit. Lesion biopsy demonstrated histological appearance and immunophenotype suggestive of colonic adenocarcinoma. Staging positron emission tomography/CT showed visceral metastases and diffuse activity in the posterior rectosigmoid, consistent with metastatic colon cancer...
2014: BMJ Case Reports
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