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rectosigmoid adenocarcinoma

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https://www.readbyqxmd.com/read/29121143/mismatch-repair-deficiency-testing-in-patients-with-colorectal-cancer-and-nonadherence-to-testing-guidelines-in-young-adults
#1
Talha Shaikh, Elizabeth A Handorf, Joshua E Meyer, Michael J Hall, Nestor F Esnaola
Importance: Mismatch repair (MMR) deficiency of DNA has been observed in up to 15% of sporadic colorectal cancers (CRCs) and is a characteristic feature of Lynch syndrome, which has a higher incidence in young adults (age, <50 years) with CRC. Mismatch repair deficiency can be due to germline mutations or epigenetic inactivation, affects prognosis and response to systemic therapy, and results in unrepaired repetitive DNA sequences, which increases the risk of multiple malignant tumors...
November 9, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29079411/capecitabine-versus-s-1-as-adjuvant-chemotherapy-for-patients-with-stage-iii-colorectal-cancer-jcog0910-an-open-label-non-inferiority-randomised-phase-3-multicentre-trial
#2
Tetsuya Hamaguchi, Yasuhiro Shimada, Junki Mizusawa, Yusuke Kinugasa, Yukihide Kanemitsu, Masayuki Ohue, Shoichi Fujii, Nobuhiro Takiguchi, Toshimasa Yatsuoka, Yasumasa Takii, Hitoshi Ojima, Hiroyuki Masuko, Yoshiro Kubo, Hideyuki Mishima, Takashi Yamaguchi, Hiroyuki Bando, Toshihiko Sato, Takeshi Kato, Kenichi Nakamura, Haruhiko Fukuda, Yoshihiro Moriya
BACKGROUND: Adjuvant chemotherapy with oral fluoropyrimidine alone after D3/D2 lymph node dissection improves disease-free survival and overall survival in patients with stage III colon cancer. Adjuvant S-1 has been shown to be non-inferior to uracil and tegafur plus leucovorin in terms of disease-free survival. This study aims to confirm the non-inferiority of S-1 compared with capecitabine as adjuvant treatment in patients with stage III colorectal cancer. METHODS: This study was an open-label, non-inferiority, randomised, phase 3, multicentre trial done in 56 Japanese centres to assess the non-inferiority of S-1 to capecitabine as adjuvant chemotherapy...
October 24, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28894583/evaluation-of-treatment-for-rectal-neuroendocrine-tumors-sized-under-20-mm-in-comparison-with-the-who-2010-guidelines
#3
Nobuhisa Matsuhashi, Takao Takahashi, Hiroyuki Tomita, Hiroshi Araki, Takashi Ibuka, Kaori Tanaka, Toshiyuki Tanahashi, Satoshi Matsui, Yoshiyuki Sasaki, Yoshihiro Tanaka, Naoki Okumura, Kazuya Yamaguchi, Shinji Osada, Kazuhiro Yoshida
Rectal neuroendocrine tumor (NET) is a relatively rare lesion of the gastrointestinal tract, but the prospective examination with colonofiberoscopy or endoscopic ultrasound has increased the frequency of its detection. It is often difficult to determine the optimal treatment for NETs sized <20 mm in the clinical setting. Other clinicopathological variables are not considered in the current guidelines and staging systems. Although the effects of lymphovascular invasion are not covered by the World Health Organization (WHO) 2010 guidelines or tumor-node-metastasis (TNM) staging system, this may be promising for the establishment of improved guidelines and staging systems, particularly for early-stage colorectal carcinoids...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28674583/-scrotal-fistulas-revealing-mucinous-adenocarcinoma-of-the-scrotum-about-a-case
#4
Abdelilah El Alaoui, Hicham El Boté, Oussama Ziouani, Oussman Dembele, Hachem El Sayegh, Ali Iken, Lounis Benslimane, Yassine Nouini
Scrotales fistulas are rare and often represent secondary lesions of tuberculosis. Mucinous adenocarcinomas are tumors containing at least 50% of extracellular mucus. They occur most commonly in the rectosigmoid; scrotal location is rare. We report the case of a 54-year old patient, with no particular past medical history, with secondary mucinous adenocarcinoma of the scrotum revealed by scrotal fistulas. The patient had suffered from recurrent scrotal fistulas for two years, with no other associated signs...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28641190/synchronous-mucinous-adenocarcinoma-of-the-recto-sigmoid-revealed-by-and-seeding-an-anal-fistula-a-case-report-and-review-of-the-literature
#5
Konstadinos G Spiridakis, Elefterios E Sfakianakis, Manthos E Flamourakis, Dimitra S Intzepogazoglou, Eleni S Tsagataki, Nikolaos E Ximeris, Efstathios K Rachmanis, Ioannis G Gionis, Giorgos E Kostakis, Manousos S Christodoulakis
INTRODUCTION: There are few cases of synchronous rectal adenocarcinoma revealed by an anal fistula. The diagnosis of synchronous mucinous adenocarcinoma of the recto sigmoid and anal canal remains difficult. The chronic anal fistula can be mistaken as the common manifestation of a benign perianal abscess or fistula. CASE PRESENTATION: We present a rare case of a Greek Caucasian 79year old male patient with anal fistula and a recurrent perianal abscess who subsequently was found to have developed synchronous rectosigmoid and perianal mucinous adenocarcinoma on biopsy...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28509310/circulating-tumor-cells-in-different-stages-of-colorectal-cancer
#6
Petra Eliasova, Michael Pinkas, Katarina Kolostova, Robert Gurlich, Vladimir Bobek
INTRODUCTION: Liquid biopsies are noninvasive tests using blood or body fluids to detect circulating tumor cells (CTCs) or the products of tumor cells, such as fragments of nucleic acids or proteins that are shed into biological fluids from primary tumor or its metastates. The analysis of published clinical studies provides coherent evidence that the presence of CTCs detected in peripheral blood is a strong prognostic factor in patients with colorectal carcinoma (CRC). The aim of the study was to implement size-based separation protocol of CTCs in CRC patients...
2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28133357/-a-case-of-unresectable-advanced-rectal-cancer-with-a-pancreatic-tumor-that-was-successfully-treated-with-folfirinox
#7
Nobushige Yabe, Shinji Murai, Hiroki Ozawa, Takahiro Yokose, Ippei Oto, Takahisa Yoshikawa, Kenjiro Kitasato, Hirotomo Shimizu, Kenji Kojima, Hirotoshi Hasegawa, Yuko Kitagawa
A 72-year-old man was admitted to our hospital department in September 2014 because of a positive fecal occult blood test.Colonoscopy showed a type 2 tumor in half of the AV 15 cm rectosigmoid colon.Histology of the biopsy indicated a moderately differentiated adenocarcinoma, and the RAS gene test found wild type.On CT examination, there were multiple liver lung metastases and a 30mm diameter tumor with pancreatic duct extension to the pancreatic body.A PET-CT examination had a high SUVmax at the same site...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27926665/clinicopathological-analysis-and-risk-factors-of-advanced-colorectal-neoplasms-incidentally-detected-by-18f-fdg-pet-ct
#8
Seung Min Chung, Kyeong Ok Kim, Ihn Ho Cho, Tae Nyeun Kim
BACKGROUND: As the clinical use of fluorine-18-fluorodeoxyglucose PET-computed tomography (F-FDG PET-CT) has increased, the incidental finding of F-FDG uptake with subsequent diagnosis of advanced neoplasm at colorectum has increased. The aim of this study is to analyze the characteristics and risk factors of advanced colorectal neoplasm incidentally detected by F-FDG PET-CT. PATIENTS AND METHODS: Patients who underwent colonoscopy because of an incidental finding of F-FDG uptake at the colorectum from January 2006 to January 2015 at Yeungnam University Hospital were reviewed retrospectively...
April 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27800205/anterior-rectal-resection-in-a-patient-with-aortoiliac-occlusive-disease-and-coexisting-collateral-pathways-management-and-pitfalls
#9
Floryn Cherbanyk, Jean-Loup Gassend, Olivier Martinet, Snezana Andrejevic-Blant, Henri-Marcel Hoogewoud
Chronic aortoiliac occlusive disease most often affects the common iliac arteries and distal aorta but can progress all the way to the renal arteries, occluding the inferior mesenteric artery. A compensatory collateral network typically develops to preserve lower body perfusion. Inadvertent compression or ligation of such collaterals during surgery can have catastrophic consequences. In this article, we present the case of a 63-year-old patient with aortoiliac occlusive disease, requiring surgery for an adenocarcinoma of the rectosigmoid junction...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27652134/right-posterior-diaphragmatic-hernia-bochdalek-with-liver-involvement-and-alteration-of-hepatic-outflow-in-adult-a-case-report
#10
Filippo Banchini, Roberta Santoni, Antonio Banchini, Flavio Cesare Bodini, Patrizio Capelli
INTRODUCTION: Posterior right diaphragmatic hernia is rare in newborn patients but when present, is accompanied by high mortality. Pulmonary hypoplasia seems to be the main cause of death but the presence of liver involvement remains one of the reasons for poor prognosis even when intrauterine surgery is performed. CASE DESCRIPTION: In this article, we will present a rare case that was diagnosed by chance in a 65-year old adult presenting with an adenocarcinoma of the rectosigmoid junction and a right Bochdalek hernia with liver herniation and modification of the hepatic vein outflow with a natural right to left shunt...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27510706/frequency-of-colonic-adenomatous-polyps-in-a-tertiary-hospital-in-mumbai
#11
Anjali D Amarapurkar, Prachi Nichat, Nitin Narawane, Deepak Amarapurkar
INTRODUCTION: Incidence of colorectal carcinoma is increasing all over world. There is limited data on colorectal polyps from India. We evaluated the histomorphological features of colorectal polyps and determined risk stratification in adenomatous polyps. METHODS: In 4970 consecutive colonoscopies, colorectal polyps were detected in 515 cases (10.3 %). Polyps were classified using standard histological criteria. Each polyp was evaluated for presence of dysplasia...
July 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27429820/intrabiliary-hepatic-metastasis-of-colorectal-carcinoma-mimicking-primary-cholangiocarcinoma-a-case-report-and-review-of-the-literature
#12
Yimin Dong, Hitendra Patel, Charmi Patel
Intrabiliary metastasis from colorectal carcinoma (CRC) growing within or invading bile ducts is not a very common pattern. However, accurate diagnosis of metastatic lesions is very important for selection of adjuvant therapy and prognosis. We report a case of 71-year-old male who developed painless jaundice due to hepatobiliary obstruction. MRI demonstrated 1.4 cm intraductal mass at hepatic hilum with severe intrahepatic ductal dilation, consistent with cholangiocarcinoma. ERCP (endoscopic retrograde cholangiopancreatography) showed intraductal segmental biliary stricture...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27422932/carbon-ion-radiotherapy-for-locally-advanced-cervical-cancer-with-bladder-invasion
#13
Shintaro Shiba, Masaru Wakatsuki, Shingo Kato, Tatsuya Ohno, Noriyuki Okonogi, Kumiko Karasawa, Hiroki Kiyohara, Hirohiko Tsujii, Takashi Nakano, Tadashi Kamada, Makio Shozu
The purpose of this study was to evaluate the efficacy and toxicities of carbon-ion radiotherapy (C-ion RT) for locally advanced cervical cancer with bladder invasion by a subset analysis of pooled data from eight prospective clinical trials at the National Institute of Radiological Sciences. Between June 1995 and January 2014, 29 patients with locally advanced cervical cancer with bladder invasion were identified. The median age was 56 years old (range 31-79 years old). The median tumor size at diagnosis on magnetic resonance imaging was 6...
November 2016: Journal of Radiation Research
https://www.readbyqxmd.com/read/27218099/incidentally-solitary-synchronous-metastatic-left-adrenal-mass-from-colon-cancer
#14
Mina Alvandipour, Mohammad Yasin Karami, Mehdi Khalvati, Hamed Khodabakhsh
The authors report the case of a 63-year-old man who underwent an open adrenalectomy for a synchronous, malignant, metastatic left adrenal tumor and a total colectomy for T3N0M1 (stage 4) primary, malignant colon cancer. Two polypoid lesions, one measuring 40 mm × 30 mm × 30 mm and the other measuring 20 mm × 10 mm × 10 mm, were found in the ascending colon and rectosigmoid (RS) junction, respectively, and a synchronous, malignant, left adrenal gland lesion measuring 70 mm × 50 mm × 30 mm was incidentally found on abdominal computed tomography scan...
April 2016: Annals of Coloproctology
https://www.readbyqxmd.com/read/27065215/using-noncontact-infrared-thermography-for-long-term-monitoring-of-foot-temperatures-in-a-patient-with-diabetes-mellitus
#15
Erik Staffa, Vladan Bernard, Luboš Kubíček, Robert Vlachovský, Daniel Vlk, Vojtěch Mornstein, Robert Staffa
Foot complications in persons with diabetes mellitus (DM) are associated with substantial costs and loss of quality of life. Increasing evidence suggests changes in skin temperature, measured using an infrared thermographic system (IRT), may be a predictor of foot ulcer development in patients with DM. The purpose of this case study is to describe the long-term IRT findings and overall clinical outcomes of a patient with DM and peripheral vascular disease. Foot temperature measurements using IRT were obtained slightly more than 1 year before and immediately following endovascular treatment of a 76-year-old man, a nonsmoker with type 2 DM, hypertension, and ischemic heart disease with cardiac arrhythmia...
April 2016: Ostomy/wound Management
https://www.readbyqxmd.com/read/26998302/sporadic-colonic-polyposis-and-adenocarcinoma-associated-with-lymphoblastic-and-large-b-cell-lymphoma-in-a-young-male-patient-a-case-report
#16
Seyed Mehdi Hashemi, Seyed Amirhossein Fazeli, Fatemeh Arabpour-Dahouei, Ali Davarian, Reza Golabchifard
We herein report a case of colonic polyposis, colorectal carcinoma and large B-cell lymphoma in a 22-year-old male patient with a previous history of childhood lymphoblastic lymphoma. Eight years after lymphoblastic lymphoma, which presented as mediastinal mass and superior vena cava syndrome, the patient complained of abdominal pain, lower gastrointestinal bleeding and an abdominal mass. The surgical exploration revealed numerous mucosal polyps throughout the large intestine, and multifocal masses in the ascending and transverse colon and the rectosigmoid region...
March 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/26838493/rectosigmoid-carcinoma-presenting-with-a-large-small-bowel-fistula
#17
María Dolores Pérez Valderas, Óscar Nogales Rincón, Javier García Lledó, Leticia Pérez Carazo, Beatriz Merino Rodríguez, Ignacio Marín Jiménez, Cecilia González Asanza, Pedro Menchén Fernández-Pacheco
No abstract text is available yet for this article.
February 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/26199250/-a-case-of-concurrent-cancer-in-a-giant-rectal-villous-adenoma-that-resulted-in-extensive-lymph-node-metastases
#18
Masahisa Ohtsuka, Taishi Hata, Masayuki Hiraki, Hiroshi Takeyama, Ryoji Nonaka, Mamoru Uemura, Junichi Nishimura, Ichiro Takemasa, Tsunekazu Mizushima, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori
The patient was a 72-year-old man. Colonoscopy revealed a circumferential villous tumor with granular aggregates extending from the rectosigmoid (RS) to the lower rectum (Rb). Although most portions were indicative of a villous adenoma, a reddish coarse region at the upper rectum (Ra) was diagnosed as a concurrent adenocarcinoma based on biopsies. Consequently, we performed laparoscopy-assisted intersphincteric resection (ISR) and D3 lymph node dissection. Pathological diagnosis revealed multiple lymph node (LN) metastases, including ones at the root of the inferior mesenteric artery (IMA)...
June 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/26160557/frequent-co-occurrence-of-high-grade-dysplasia-in-large-flat-colonic-polyps-20-mm-and-synchronous-polyps
#19
Tianzuo Zhan, Felix Hahn, Thomas Hielscher, Johannes Betge, Georg Kähler, Matthias P Ebert, Sebastian Belle
BACKGROUND: Large colonic polyps are associated with advanced dysplasia, but prevalence and characteristics of synchronous polyps in patients with large flat colonic polyps are poorly investigated. This study aims to characterize clinicopathological features of large flat colonic polyps and their impact on occurrence and characteristics of synchronous polyps. METHODS: A total of 802 patients that underwent endoscopic mucosal resection (EMR) of flat colonic polyps >20 mm from 2003 to 2014 in an academic endoscopy unit were retrospectively analyzed for size, location and histology of large polyps and synchronous polyps...
2015: BMC Gastroenterology
https://www.readbyqxmd.com/read/26064730/a-case-report-of-long-term-survival-following-hepatic-arterial-infusion-of-l-folinic-acid-modulated-5-fluorouracil-combined-with-intravenous-irinotecan-and-cetuximab-followed-by-hepatectomy-in-a-patient-with-initially-unresectable-colorectal-liver-metastases
#20
Kobe Van Bael, Yanina Jansen, Teofila Seremet, Benedikt Engels, Georges Delvaux, Bart Neyns
A 43-year-old women admitted to our hospital for weight loss, anorexia, and abdominal pain was diagnosed with sigmoid neoplasm and multiple bilobar liver metastases. This patient received six cycles of systemic FOLFOX prior to a laparoscopically assisted anterior resection of the rectosigmoid for a poorly differentiated invasive adenocarcinoma T2N2M1, K-RAS negative (wild type). Hepatic arterial infusion (HAI) of L-folinic acid modulated 5-fluorouracil (LV/5-FU) with intravenous (iv) irinotecan (FOLFIRI) and cetuximab as adjuvant therapy resulted in a complete metabolic response (CR) with CEA normalization...
2015: Case Reports in Oncological Medicine
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