keyword
MENU ▼
Read by QxMD icon Read
search

antifungal combination therapy

keyword
https://www.readbyqxmd.com/read/29783858/effectiveness-and-safety-comparison-for-systemic-corticosteroid-therapy-with-and-without-inhaled-corticosteroids-for-copd-exacerbation-management
#1
Jordan A Pearce, Dane L Shiltz, Qian Ding
BACKGROUND: Only 1 small, single-center study has evaluated the combination of systemic plus inhaled corticosteroid (ICS) routes for chronic obstructive pulmonary disease (COPD) exacerbation management. This study aims to further improve the existing quantity and quality of evidence regarding the utility for combination therapy in the management of COPD exacerbation. OBJECTIVES: To evaluate length of hospital stay, readmission rate, incidence of infection, and mortality in hospitalized patients who experience a COPD exacerbation and receive systemic corticosteroid therapy with or without concurrent ICS...
May 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29782305/tatami-mats-a-source-of-pitted-keratolysis-in-a-martial-arts-athlete
#2
Anamaria Balić, Zrinka Bukvić Mokos, Branka Marinović, Daniela Ledić Drvar
Dear Editor, Pitted keratolysis (PK), also known as keratosis plantaris sulcatum, is a non-inflammatory, bacterial, superficial cutaneous infection, characterized by many discrete superficial crateriform ''pits'' and erosions in the thickly keratinized skin of the weight-bearing regions of the soles of the feet (1). The disease often goes unnoticed by the patient, but when it is noticed it is because of the unbearable malodor and hyperhidrosis of the feet, which are socially unacceptable and cause great anxiety to many of the patients...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29774477/cefepime-vs-cefoperazone-sulbactam-in-combination-with-amikacin-as-empirical-antibiotic-therapy-in-febrile-neutropenia
#3
M Ponraj, Biswajit Dubashi, B H Harish, S Kayal, S L Cyriac, Jogamaya Pattnaik, K Ranjith, Unni S Pillai, Naresh Jadhav, Kiran K Matta, Jagdeep Singh, Esha Jaffa, Bhanu Prakash
PURPOSE: Beta lactams are standard empirical therapy for febrile neutropenia (FN). The aim of this study was to evaluate the efficacy and safety of cefepime monotherapy compared with cefoperazone/sulbactam plus amikacin (CS + A) for empirical treatment of high risk FN. METHODS: One hundred seventy-five patients with 336 FN episodes were randomized to receive either cefepime (2 g q8h for adults and 50 mg/kg q8h for children) or CS (2 g q8h for adults and 50 mg/kg q8h for children) plus amikacin (15 mg/kg once a day)...
May 17, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29767317/successful-sequential-treatment-with-itraconazole-and-ala-pdt-for-cutaneous-granuloma-by-candida-albicans-a-case-report-and-literature-review
#4
Qing Cai, Lian-Juan Yang, Jia Chen, Hong Yang, Zhi-Qin Gao, Xiu-Li Wang
Photodynamic therapy (PDT) is a process that combines a photosensitizing drug and light and promotes phototoxic responses in target cells, mainly via oxidative damage. Antifungal photodynamic therapy has been successfully employed against Candida species, dermatophytes, and deep mycoses. We present a case of a cutaneous granuloma caused by C. albicans treated with 5-aminolevulinic acid (ALA)-PDT. A 64-year-old man presented with two plaques on his right hand and wrist for 2 years. The diagnosis was made based on histopathology, mycology, and molecular identification of paraffin-embedded tissues...
May 16, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29747285/-expert-consensus-on-the-diagnosis-and-treatment-of-cryptococcal-meningitis
#5
Z Y Liu, G Q Wang, L P Zhu, X J Lyu, Q Q Zhang, Y S Yu, Z H Zhou, Y B Liu, W P Cai, R Y Li, W H Zhang, F J Zhang, H Wu, Y C Xu, H Z Lu, T S Li
Cryptococcal meningitis is a common and refractory central nervous system infection, with high rates of mortality and disability. The experts of the Society of Infectious Diseases of Chinese Medical Association have reached this consensus after a thorough discussion. Based on the current situation of cryptococcal meningitis in China, the management of cryptococcal meningitis includes 6 aspects: introduction, microorganism identification, clinical manifestations and diagnosis, principles of antifungal therapy, treatment of refractory and recurrent meningitis, treatment of intracranial hypertension...
May 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29739053/fungal-infection-caused-by-geotrichum-capitatum-in-a-severe-aplastic-anemia-patient-a-case-report-and-review-of-the-literature
#6
Wulin Shan, Chunyang Dai, Jingsong Kan, Ming Li, Meiling Yin
BACKGROUND: Invasive fungal infections often occur in immunocompromised patients. Here, we report an infection case caused by Geotrichum capitatum in a severe aplastic anemia patient. METHODS: Identification of the pathogenic bacteria was done by sequencing and mass spectrometric analysis. RESULTS: The fungal infection was isolated from blood cultures. The pathogenic bacteria were identified as Geotrichum capitatum. The infection was primarily cured by voriconazole and caspofungin monotherapy...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29719792/acute-exacerbation-of-idiopathic-pulmonary-fibrosis-triggered-by-aspergillus-empyema
#7
Atsushi Suzuki, Tomoki Kimura, Kensuke Kataoka, Toshiaki Matsuda, Toshiki Yokoyama, Yuta Mori, Yasuhiro Kondoh
Acute exacerbation (AE) is a severe and life-threatening complication of idiopathic pulmonary fibrosis (IPF). In 2016, the definition and diagnostic criteria for AE-IPF were updated by an international working group. The new definition includes any acute, clinically significant respiratory deterioration (both idiopathic and triggered events) characterized by evidence of new widespread alveolar abnormality in patients with IPF. There are no currently proven beneficial management strategies for idiopathic and triggered AE-IPF...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29705891/keratomycosis-due-to-tintelnotia-destructans-refractory-to-common-therapy-treated-successfully-with-systemic-and-local-terbinafine-in-combination-with-polyhexamethylene-biguanide
#8
Wolfgang J Behrens-Baumann, Wolfram Hofmüller, Ina Tammer, Kathrin Tintelnot
PURPOSE: To report on a wearer of rigid gas-permeable contact lenses with a keratomycosis due to Tintelnotia-a new genus of Phaeosphaeriaceae-treated with terbinafine and polyhexamethylene biguanide. METHODS: Chart review of a patient with fungal keratitis treated additionally with systemic and topical terbinafine 0.25% after symptoms increased under conventional antimycotic therapy with voriconazole. Antifungal susceptibility had been tested in vitro. RESULTS: After starting an additional treatment with systemic and topical terbinafine, the severe corneal infection was sufficiently resolved...
April 28, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29677084/voriconazole-treatment-for-an-infant-with-intractable-candida-glabrata-meningitis
#9
Sophia Tsakiri, Chiamaka Aneji, Christine Domonoske, Lynnette Mazur, Daniel K Benjamin, Susan H Wootton
We report voriconazole levels in an infant with disseminated Candida glabrata infection who received combination antifungal therapy and rescue voriconazole treatment. Serum and CSF voriconazole levels were higher than anticipated and above target. Dose reduction did not lead to a reduction in the blood or CSF levels. The patient did not exhibit identifiable drug toxicity.
April 19, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29671631/antimicrobial-sonodynamic-and-photodynamic-therapies-against-candida-albicans
#10
Fernanda Alves, Ana Cláudia Pavarina, Ewerton Garcia de Oliveira Mima, Anthony P McHale, John Francis Callan
Candida albicans biofilms exhibit unique characteristics and are highly resistant to antifungal agents. Antimicrobial photodynamic therapy (aPDT) is an alternative treatment limited to treating superficial infections due to the poor light penetration. In this manuscript, the antifungal properties of sonodynamic therapy (SDT) were assessed. SDT uses ultrasound instead of light, enabling the treatment of deeper infections. Planktonic cells and biofilms of C. albicans were treated with aPDT or SDT, in addition to combined aPDT/SDT, with cell survival determined using colony forming units...
April 19, 2018: Biofouling
https://www.readbyqxmd.com/read/29658789/effect-of-2-phenylethanol-as-antifungal-agent-and-common-antifungals-amphotericin-b-fluconazole-and-itraconazole-on-candida-species-isolated-from-chronic-and-recurrent-cases-of-candidal-vulvovaginitis
#11
Niloufar Majdabadi, Mehraban Falahati, Fariba Heidarie-Kohan, Shirin Farahyar, Parvaneh Rahimi-Moghaddam, Mahtab Ashrafi-Khozani, Tandis Razavi, Sina Mohammadnejad
The antifungal effects of 2-phenylethanol are clearly visible through its intervention in Candida morphogenesis. Chronic and recurrent vulvovaginitis, however, does not respond to this standard experimental therapy; therefore, the study presented in this article investigated the effect of common antifungal drugs (amphotericin B [AMB], fluconazole [FLU], and itraconazole [ITC]), in combination with 2-phenylethanol, on the Candida species isolated from cases of chronic and recurrent vulvovaginitis, thereby allowing the recommendation of a more appropriate treatment option...
April 2018: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/29653177/additive-potential-of-combination-therapy-against-cryptococcosis-employing-a-novel-amphotericin-b-and-fluconazole-loaded-dual-delivery-system
#12
Azmat Ali Khan, Amer M Alanazi, Mumtaz Jabeen, Shahnavaj Khan, Abdul Mallik
Cryptococcus neoformans is one of the most lethal fungi causing mortality across the globe with the highest incidences in immuno-compromised person. Patients taking immuno-suppressive medications and immuno-competent hosts are extremely susceptible to its infection. Thus, new forms of therapy are urgently required for effective cure to the fungal burden. So, in the present study we have tried to explore the potential effects of amphotericin B (AMB) and fluconazole (FLC) in combination antifungal drug therapy...
April 10, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29648533/the-effect-of-fluconazole-on-the-pharmacokinetics-of-everolimus-and-tacrolimus-in-a-heart-transplant-recipient-a-case-report
#13
Kazuki Nakagita, Kyoichi Wada, Yuka Terada, Sachi Matsuda, Nobue Terakawa, Akira Oita, Mitsutaka Takada
OBJECTIVE: Everolimus is an inhibitor of the mammalian target of rapamycin (mTOR) and has been used in combination with calcineurin inhibitors (tacrolimus and cyclosporine) to prevent allograft rejection following organ transplantation. In heart transplant recipients, everolimus should be maintained at a target blood concentration of 3 - 8 ng/mL, in combination with reduced-dose calcineurin inhibitors and therefore, requires strict monitoring. Fluconazole, an azole antifungal agent, affects blood concentration of tacrolimus by inhibiting the cytochromes P450 (CYP) 3A4 and 3A5...
April 12, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29629650/fusarium-keratoplasticum-infection-in-an-hiv-infected-patient
#14
Alice Annalisa Medaglia, Javier Marco-Hernández, José Tomás de Ossó Acuña, Evelyn Hermida Lama, María Martínez-Rebollar, Miguel Caballero, Leonardo Rodríguez-Carunchio, Felipe García
Fusarium infections are very rare in HIV-infected patients, even in patients in advanced stages of immunosuppression. All the reported cases in the literature are of disseminated infection, and with poor outcomes despite prompt and appropriate treatment. To the best of our knowledge, this is the first report of a localized infection with Fusarium keratoplasticum in an HIV-positive patient, successfully treated with a combination of antifungal therapy and surgical removal of the focus.
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29624015/photodynamic-therapy-of-red-and-blue-lights-on-malassezia-pachydermatis-an-in-vitro-study
#15
W R Kim, S G Bae, T H Oh
In veterinary medicine, infection caused by Malassezia pachydermatis is spreading and necessity of alternative treatment is emphasized. Photodynamic therapy (PDT) is therapeutic method using specific spectrum of light with photosensitizer. In this study, applying PDT not only using red light which is used in human medicine commonly, but also using blue light into skin infection causative microorganism with photosensitizer, confirm the effect of PDT and possibility of being an alternative treatment. Four isolates of M...
March 2018: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29610204/scy-078-a-novel-oral-glucan-synthase-inhibitor-for-the-treatment-of-invasive-aspergillosis-evaluation-of-antifungal-activity-singly-and-in-combination
#16
M Ghannoum, L Long, E L Larkin, N Isham, R Sherif, K Borroto-Esoda, S Barat, D Angulo
Invasive aspergillosis remains a major cause of death among the immunocompromised population and those receiving long-term immunosuppressive therapy. In light of increased azole resistance, variable outcomes with existing echinocandin mono and combination therapy, and persistent high mortality rates, new antifungal agents for the treatment of invasive aspergillosis are clearly needed.SCY-078 is the first in class triterpenoid antifungal, a novel class of glucan synthase inhibitors, with broad in vitro and in vivo activity against a broad spectrum of Candida and Aspergillus In vitro testing of clinical strains of Aspergillus fumigatus and non- fumigatus strains showed potent fungistatic activity of SCY-078 (minimum effective concentration, MEC90 = 0...
April 2, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29608751/t2candida-mr-as-a-predictor-of-outcome-in-patients-with-suspected-invasive-candidiasis-starting-empirical-antifungal-treatment-a-prospective-pilot-study
#17
Patricia Muñoz, Antonio Vena, Marina Machado, Francesca Gioia, María Carmen Martínez-Jiménez, Elia Gómez, Julia Origüen, María Ángeles Orellana, Francisco López-Medrano, Mario Fernández-Ruiz, Paloma Merino, Fernando González-Romo, Isabel Frías, María-Jesús Pérez-Granda, José María Aguado, Jesús Fortún, Emilio Bouza
Objectives: We assessed the potential role of T2Candida MR (T2MR) and serological biomarkers [β-d-glucan (BDG) or Candida albicans germ tube antibodies (CAGTA)], alone or in combination with standard cultures, for identifying patients with suspected invasive candidiasis (IC), who may benefit from maintaining antifungal therapy. Methods: Prospective observational multicentre study including all adult patients receiving empirical antifungal therapy for suspected IC, from January to June 2017...
March 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29604972/cryptococcal-meningitis-in-aids
#18
Andrej Spec, William G Powderly
Cryptococcal meningitis remains a significant cause of morbidity and mortality amongst patients living with human immunodeficiency virus (HIV). The prevalence in the developed world has decreased as HIV is being diagnosed earlier, but is still significant, and the prevalence in resource-limited settings is exceedingly high. The presenting symptoms usually include a headache, fever, and, less often, cranial nerve abnormalities. Space-occupying lesions do occur, but are rare. Once diagnosed, patients should be treated with a combination of amphotericin and flucytosine, with step-down therapy to fluconazole for a minimum of a year, or until the CD4 count is above 100 cells/μL, whichever is longer...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29593675/cryptococcal-antigen-screening-in-asymptomatic-hiv-infected-antiretroviral-na%C3%A3-ve-patients-in-cameroon-and-evaluation-of-the-new-semi-quantitative-biosynex-cryptops-test
#19
Elvis Temfack, Charles Kouanfack, Leonella Mossiang, Angela Loyse, Marie C Fonkoua, Síle F Molloy, Sinata Koulla-Shiro, Eric Delaporte, Françoise Dromer, Thomas Harrison, Olivier Lortholary
Background: Cryptococcal meningitis (CM) is a major cause of AIDS-related mortality in Africa. Detection of serum cryptococcal antigen (CrAg) predicts development of CM in antiretroviral (ART) naïve HIV-infected patients with severe immune depression. Systematic pre-ART CrAg screening and pre-emptive oral fluconazole is thus recommended. We postulated that a semi-quantitative CrAg screening approach could offer clinically relevant advantages. Methods: ART-naïve asymptomatic adult outpatients with <100 CD4 cells/mm3 presenting to the Yaoundé Central Hospital, Cameroon were screened for CrAg using the IMMY lateral flow assay (LFA)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29579771/the-human-respiratory-microbiome-implications-and-impact
#20
Alicia B Mitchell, Allan R Glanville
Once considered a sterile site below the larynx, the tracheobronchial tree and parenchyma of the lungs are now known to harbor a rich diversity of microbial species including bacteria, viruses, fungi, and archaea. Many of these organisms, particularly the viruses which comprise the human respiratory virome, have not been identified, so their true role is unknown. It seems logical to conclude that a "healthy" respiratory microbiome exists which may be modified in disease states and perhaps by therapies such as antibiotics, antifungals, and antiviral treatments...
April 2018: Seminars in Respiratory and Critical Care Medicine
keyword
keyword
63806
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"