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Inhaler adherence

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https://www.readbyqxmd.com/read/29653218/comparing-ran-out-status-of-inhaled-short-acting-beta-agonists-in-emergency-department-patients-with-acute-asthma-1996-1998-versus-2015-2017
#1
Tadahiro Goto, Carlos A Camargo, Catalina Gimenez-Zapiola, Daniel J Pallin, Nathan I Shapiro, Thomas J Ferro, Carolyn Rainville, Stanislav Stoyanov, Kohei Hasegawa
BACKGROUND: Medication non-adherence including running out of inhaled asthma medications, is an important problem. OBJECTIVE: To examine the changes in the proportion of adults with acute asthma who ran out of their short-acting beta-agonist (SABA) inhalers before presenting to the emergency department (ED) between 1996-1998 and 2015-2017. METHODS: We analyzed data from prospective multicenter observational cohort studies of ED adult patients (aged 18-54 years) with acute asthma...
April 10, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29629401/pattern-and-adherence-to-maintenance-medication-use-in-medicare-beneficiaries-with-chronic-obstructive-pulmonary-disease-2008-2013
#2
Shawn P E Nishi, Matthew Maslonka, Wei Zhang, Yong-Fang Kuo, Gulshan Sharma
Background: Maintenance medications provide symptomatic relief, improve lung function and reduce the risk of exacerbations in patients with chronic obstructive pulmonary disease (COPD). Despite their proven benefits, limited information exists on maintenance medication use and adherence among users. Objective: We examined the patterns and factors associated with the receipt of and adherence to maintenance medication in individuals with COPD. Methods: A retrospective cross-sectional study of 5% of Medicare beneficiaries enrolled in Parts A, B and D with COPD who received maintenance medication from 2008 to 2013 was conducted...
January 24, 2018: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://www.readbyqxmd.com/read/29627457/relationship-of-inhaled-corticosteroid-adherence-to-asthma-exacerbations-in-patients-with-moderate-to-severe-asthma
#3
Alberto Papi, Dermot Ryan, Joan B Soriano, Henry Chrystyn, Leif Bjermer, Roberto Rodríguez-Roisin, Myrna B Dolovich, Mark Harris, Lucy Wood, Maria Batsiou, Susannah I Thornhill, David B Price
BACKGROUND: Patients with asthma and elevated blood eosinophils are at increased risk of severe exacerbations. Management of these patients should consider non-adherence to inhaled corticosteroid (ICS) therapy as a factor for increased exacerbation risk. OBJECTIVE: To investigate whether poor adherence to ICS therapy explains the occurrence of asthma exacerbations in patients with elevated blood eosinophil levels. METHODS: This historical cohort study identified patients within the Optimum Patient Care Research Database, aged ≥18 years, at Global Initiative for Asthma (GINA) steps 3 or 4, with ≥2 ICS prescriptions during the year prior to clinical review...
April 5, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29624458/burden-of-asthma-among-patients-adherent-to-ics-laba-a-real-world-study
#4
Jill Davis, Frank Trudo, James Siddall, Mark Small
OBJECTIVES: Asthma is a chronic respiratory condition with a U.S. prevalence of 7.4%. Despite numerous treatment options, asthma remains poorly controlled in some patients. Uncontrolled asthma is associated with high healthcare resource utilization (HCRU) and reduced productivity. This study assessed symptoms, productivity, and HCRU of patients adherent to medium/high-dosage inhaled corticosteroid/long-acting beta2-agonist (ICS/LABA) treatment, and the relationship of asthma control with these parameters...
April 6, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29621625/ciprofloxacin-dry-powder-for-inhalation-ciprofloxacin-dpi-technical-design-and-features-of-an-efficient-drug-device-combination
#5
REVIEW
Pamela J McShane, Jeffry G Weers, Thomas E Tarara, Alfred Haynes, Preeti Durbha, Danforth P Miller, Tobias Mundry, Elisabeth Operschall, J Stuart Elborn
Bronchiectasis is a chronic respiratory disease with heterogeneous etiology, characterized by a cycle of bacterial infection and inflammation, resulting in increasing airway damage. Exacerbations are an important cause of morbidity and are strongly associated with disease progression. Many patients with bronchiectasis suffer from two or more exacerbations per year. However, there are no approved therapies to reduce or delay exacerbations in this patient population. Ciprofloxacin DPI is in development as a long-term, intermittent therapy to reduce exacerbations in patients with non-cystic fibrosis (CF) bronchiectasis and evidence of respiratory pathogens...
April 2, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29614508/diagnosis-and-management-of-asthma-the-swiss-guidelines
#6
Thomas Rothe, Paolo Spagnolo, Pierre-Olivier Bridevaux, Christian Clarenbach, Christine Eich-Wanger, Franca Meyer, David Miedinger, Alexander Möller, Laurent P Nicod, Geneviève Nicolet-Chatelain, Alain Sauty, Claudia Steurer-Stey, Joerg D Leuppi
The Global Initiative for Asthma (GINA) is a network of individuals, organizations, and public health officials that was established to disseminate information about the care of patients with asthma and to improve asthma care. The GINA ("Global Strategy for Asthma Management and Prevention") report has been updated annually since 2002. Due to new knowledge and therapeutic development in the field, the Swiss Respiratory Society felt the need to provide a new document that is based on both the available literature and the recommendations of the 2016 GINA report...
April 3, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29596267/a-stewardship-program-to-optimize-the-use-of-inhaled-nitric-oxide-in-pediatric-critical-care
#7
Tanya Di Genova, Christina Sperling, Ashley Gionfriddo, Zelia Da Silva, Leanne Davidson, Jason Macartney, Michael Finelli, Robert P Jankov, Peter C Laussen
PURPOSE: Inhaled nitric oxide (iNO) is a pulmonary vasodilator that is approved for use in term and near-term neonates with hypoxic respiratory failure associated with evidence of pulmonary hypertension. However, it is commonly used in infants and children to treat a variety of other cardiopulmonary diseases associated with pulmonary hypertension and hypoxic respiratory failure. In critically ill children, iNO therapy may be continued for a prolonged period, and this increases the risk for adverse consequences including toxicity and unnecessary costs...
April 2018: Quality Management in Health Care
https://www.readbyqxmd.com/read/29592540/reported-problems-and-adherence-in-using-asthma-medications-among-adolescents-and-their-caregivers
#8
Betsy Sleath, Daniel Gratie, Delesha Carpenter, Scott A Davis, Charles Lee, Ceila E Loughlin, Nacire Garcia, Daniel S Reuland, Gail Tudor
BACKGROUND: Many factors affect youth adherence to asthma medications. Better understanding of the relationship between problems reported by youth in using asthma medications, self-efficacy, outcome expectations, and adherence is needed. OBJECTIVE: The study examined the relationship between youth and caregiver problems in using asthma medications, asthma management self-efficacy, outcome expectations, and youth- and caregiver-reported adherence to asthma controller medications...
March 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29589381/continued-innovation-in-respiratory-care-the-importance-of-inhaler-devices
#9
REVIEW
Sinthia Zrinka Bosnic-Anticevich
When it comes to the use in inhalers in the management of chronic obstructive pulmonary diseases, there are many options, considerations and challenges, which health care professionals need to address. Considerations for prescribing and dispensing, administering and following up, education, and adherence; all of these factors impact on treatment success and all are intrinsically linked to the device selected. This review brings together relevant evidence, real-life data and practice tools to assist health care professionals in making decisions about the use of inhalers in the management of chronic obstructive pulmonary diseases...
April 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29559538/patient-satisfaction-with-inhaled-medication-for-asthma
#10
Ashutosh N Aggarwal, Raman Kumari, Sandeep Grover
BACKGROUND: We sought to compare treatment satisfaction with inhaled medications among asthmatics using a metered-dose inhaler (MDI) or a dry-powder inhaler (DPI), and to correlate satisfaction with treatment adherence, pulmonary function, and airway inflammation. METHODS: Spirometry, fraction of expired nitric oxide (FENO ), and asthma control were assessed in 200 adult subjects with asthma (69 men, 131 women) using MDI or DPI. Treatment satisfaction with inhaled therapy was assessed with the Treatment Satisfaction Questionnaire for Medication (TSQM) in 4 domains: Effectiveness, Side Effects, Convenience, and Global Satisfaction...
March 20, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29557596/severe-asthma-in-pediatrics-outcomes-of-the-implementation-of-a-special-health-care-protocol
#11
Verónica Giubergia, María J Ramirez Farías, Verónica Pérez, Adriana González, Nancy Crespi, Nora Fridman, Claudio Castaños
INTRODUCTION: Severe asthma accounts for 5-7% of all asthma cases. The World Health Organization proposed a follow-up protocol to classify cases into severe, treatment-resistant asthma (STRA) or severe, difficult-to-control asthma (SDCA). OBJECTIVE: To analyze the clinical, functional, and therapeutic characteristics of patients with STRA or SDCA. METHODS: Cross-sectional, observational, and analytical study to assess the diagnosis, the extent of control (clinical and functional), comorbidities, treatment adherence, inhalation technique, and environmental factors in patients with severe asthma...
April 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29557582/inhalation-therapy-in-the-next-decade-determinants-of-adherence-to-treatment-in-asthma-and-copd
#12
Claudio F Donner, Sandro Amaducci, Elena Bacci, Sandra Baldacci, Maria L Bartoli, Gianfranco M Beghi, Alida Benfante, Sara Brighindi, Lucio Casali, Daniela Castiglia, Mario Cazzola, Alessandro Celi, Silvana Cianchetti, Giorgio Colombo, Claudia Crimi, Federico L Dente, Giuseppe Di Maria, Annalisa Di Maria, Manuela Latorre, Federico Lavorini, Sara Maio, Claudia Mannini, Riccardo Messina, Pier Luigi Paggiaro, Patrizia Pignatti, David Price, Nicola Scichilone, Marzia Simoni, Antonio Spanevello, Martina Stagno d'Alcontres, Shawna Tan, Roberto Torchio, Giovanni Viegi, Dina Visca, Emiel F M Wouters, Shaylynn Yu Hui Xin
Proceedings of the European Seminars in Respiratory Medicine course, Inhalation therapy in the next decade: Determinants of adherence to treatment in asthma and COPD, held in Taormina, Italy, on 3-4 March, 2017.
February 2, 2018: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/29553450/management-of-chronic-obstructive-pulmonary-disease-exacerbations-at-the-nasser-medical-complex-a-clinical-audit
#13
Maha Al-Faqawi, Yousef Abuowda, Alaa Eldeen Elmassry, Bettina Böttcher
BACKGROUND: The frequency and severity of chronic obstructive pulmonary disease (COPD) exacerbations are the most important determinants of prognosis in COPD. The aim of this study was to assess the management of patients presenting with COPD exacerbations at the Nasser Medical Complex in the Gaza Strip and to compare the management with the Global Initiative for Chronic Obstructive Lung Disease guidelines (GOLD 2015). METHODS: We reviewed the medical records of all patients admitted to Nasser Medical Complex and diagnosed with COPD exacerbation between Jan 1, 2014, and Dec 31, 2016...
February 21, 2018: Lancet
https://www.readbyqxmd.com/read/29545018/-persistence-to-treatment-and-resources-use-with-inhaled-fixed-dose-combinations-of-corticosteroids-and-long-acting-%C3%AE-adrenergic-agonists-for-the-treatment-of-asthma-a-population-based-retrospective-study
#14
A Sicras-Mainar, S Traseira-Lugilde, T Fernández-Sánchez, R Navarro-Artieda
OBJECTIVE: To determine the persistence, exacerbations, and use of resources in patients who use inhaler treatment with fluticasone propionate/formoterol (PF/Form) in relation with other combinations of inhaled corticosteroid/long-acting β-adrenergic (ICS/LABA) at fixed doses, for the treatment of asthma in real-life practice. MATERIAL AND METHODS: Observational study conducted by reviewing medical records. The study included subjects ≥18 years of age who started treatment with ICS/LABA and who met certain inclusion/exclusion criteria...
March 12, 2018: Semergen
https://www.readbyqxmd.com/read/29541999/in-vitro-evaluation-of-the-inhalable-quercetin-loaded-nanoemulsion-for-pulmonary-delivery
#15
Noor Hafizah Arbain, Norazlinaliza Salim, Hamid Reza Fard Masoumi, Tin Wui Wong, Mahiran Basri, Mohd Basyaruddin Abdul Rahman
Bioavailability of quercetin, a flavonoid potentially known to combat cancer, is challenging due to hydrophobic nature. Oil-in-water (O/W) nanoemulsion system could be used as nanocarrier for quercertin to be delivered to lung via pulmonary delivery. The novelty of this nanoformulation was introduced by using palm oil ester/ricinoleic acid as oil phase which formed spherical shape nanoemulsion as measured by transmission electron microscopy and Zetasizer analyses. High energy emulsification method and D-optimal mixture design were used to optimize the composition towards the volume median diameter...
March 14, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29536984/wechat-public-account-use-improves-clinical-control-of-cough-variant-asthma-a-randomized-controlled-trial
#16
Yuan Cao, Shi-Hua Lin, Ding Zhu, Feng Xu, Zhi-Hua Chen, Hua-Hao Shen, Wen Li
BACKGROUND WeChat is a convenient and popular social medium, and it seems to be an appropriate platform for education and management of patients. This study sought to identify usefulness in clinical control of cough-variant asthma (CVA). MATERIAL AND METHODS A randomized controlled trial was conducted among 80 CVA patients. After being assigned to either the traditional group (TG) or the WeChat group (WG), they received the same inhalation therapy, but patients in WG received additional education and instruction via our public account on the WeChat application...
March 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29520137/factors-associated-with-appropriate-inhaler-use-in-patients-with-copd-lessons-from-the-real-survey
#17
David Price, Dorothy L Keininger, Boomi Viswanad, Matthias Gasser, Susann Walda, Florian S Gutzwiller
Background: Nonadherence to medication and incorrect use of inhalers represent significant barriers to optimal disease management of patients with chronic obstructive pulmonary disease (COPD). Thus, health care professionals (HCPs) play a critical role in educating their patients on appropriate inhaler use and in ensuring medication adherence. However, many patients do not receive appropriate inhaler training or have not had their inhaler technique checked. Methods: The Real-life Experience and Accuracy of inhaLer use (REAL) survey was a computer-assisted, telephonic survey consisting of 23 questions gathering real-world information on correct inhaler use, inhalation technique, device attributes, adherence, dosing accuracy, training, correct device use, ease of use, and factors that influence patient adherence in commercially available inhalers delivering COPD maintenance therapy...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29519922/non-adherence-in-the-era-of-severe-asthma-biologics-and-thermoplasty
#18
Joy Lee, Tunn Ren Tay, Naghmeh Radhakrishna, Fiona Hore-Lacy, Anna Mackay, Ryan Hoy, Eli Dabscheck, Robyn O'Hehir, Mark Hew
Non-adherence to inhaled preventers impairs asthma control. Electronic monitoring devices (EMD) can objectively measure adherence. Their use has not been reported in difficult asthma patients potentially suitable for novel therapies, i.e. biologics and bronchial thermoplasty.Consecutive patients with difficult asthma were assessed for eligibility for novel therapies. Medication adherence, defined as taking 75% or more of prescribed doses, was assessed by EMD and compared to standardised clinician assessment over an eight week period...
March 8, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29518252/interventions-for-autumn-exacerbations-of-asthma-in-children
#19
REVIEW
Katharine C Pike, Melika Akhbari, Dylan Kneale, Katherine M Harris
BACKGROUND: Asthma exacerbations in school-aged children peak in autumn, shortly after children return to school following the summer holiday. This might reflect a combination of risk factors, including poor treatment adherence, increased allergen and viral exposure, and altered immune tolerance. Since this peak is predictable, interventions targeting modifiable risk factors might reduce exacerbation-associated morbidity and strain upon health resources. The peak occurs in September in the Northern Hemisphere and in February in the Southern Hemisphere...
March 8, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29512893/outcome-evaluation-of-a-pharmacy-based-therapy-management-program-for-patients-with-cystic-fibrosis
#20
Heather S Kirkham, Francis Staskon, Nishita Hira, Darren McLane, Karl M Kilgore, Alexis Parente, Seung Kim, Gregory S Sawicki
OBJECTIVE: To compare medication adherence, pulmonary exacerbations, healthcare utilization, and costs for patients with cystic fibrosis (CF) who utilized a pharmacy-based therapy management program to a matched control group. We hypothesized that patient management services would be associated with better medication adherence, and thus require fewer visits to the emergency room or hospitalizations. METHODS: This retrospective, observational cohort study used claims data from the MORE2 claims Registry®...
March 7, 2018: Pediatric Pulmonology
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