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Electronic adherence monitor

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https://www.readbyqxmd.com/read/29669705/diabetes-related-behavior-change-knowledge-transfer-to-primary-care-practitioners-and-patients-implementation-and-evaluation-of-a-digital-health-platform
#1
Samina Abidi, Michael Vallis, Helena Piccinini-Vallis, Syed Ali Imran, Syed Sibte Raza Abidi
BACKGROUND: Behavioral science is now being integrated into diabetes self-management interventions. However, the challenge that presents itself is how to translate these knowledge resources during care so that primary care practitioners can use them to offer evidence-informed behavior change support and diabetes management recommendations to patients with diabetes. OBJECTIVE: The aim of this study was to develop and evaluate a computerized decision support platform called "Diabetes Web-Centric Information and Support Environment" (DWISE) that assists primary care practitioners in applying standardized behavior change strategies and clinical practice guidelines-based recommendations to an individual patient and empower the patient with the skills and knowledge required to self-manage their diabetes through planned, personalized, and pervasive behavior change strategies...
April 18, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29657978/relationship-between-electronically-measured-medication-adherence-and-vision-related-quality-of-life-in-a-cohort-of-patients-with-open-angle-glaucoma
#2
Atalie C Thompson, Sandra Woolson, Maren K Olsen, Susanne Danus, Hayden B Bosworth, Kelly W Muir
Objective: To investigate whether electronically measured medication adherence is associated with vision-related quality of life (VRQoL) in patients with open-angle glaucoma. Methods and analysis: This is a 3-year prospective cohort study of 79 subjects with open-angle glaucoma at a Veterans Affairs medical centre. Participants returned a medication event monitoring system (MEMS) for their glaucoma eye-drops and had at least two visits with glaucoma during the study period...
2018: BMJ Open Ophthalmology
https://www.readbyqxmd.com/read/29652246/metformin-in-non-diabetic-hyperglycaemia-the-glint-feasibility-rct
#3
Simon J Griffin, M Angelyn Bethel, Rury R Holman, Kamlesh Khunti, Nicholas Wareham, Gwen Brierley, Melanie Davies, Andrew Dymond, Rose Eichenberger, Philip Evans, Alastair Gray, Colin Greaves, Kyla Harrington, Graham Hitman, Greg Irving, Sarah Lessels, Ann Millward, John R Petrie, Martin Rutter, Mike Sampson, Naveed Sattar, Stephen Sharp
BACKGROUND: The treatment of people with diabetes with metformin can reduce cardiovascular disease (CVD) and may reduce the risk of cancer. However, it is unknown whether or not metformin can reduce the risk of these outcomes in people with elevated blood glucose levels below the threshold for diabetes [i.e. non-diabetic hyperglycaemia (NDH)]. OBJECTIVE: To assess the feasibility of the Glucose Lowering In Non-diabetic hyperglycaemia Trial (GLINT) and to estimate the key parameters to inform the design of the full trial...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29642874/pilot-evaluation-of-a-second-generation-electronic-pill-box-for-adherence-to-bedaquiline-and-antiretroviral-therapy-in-drug-resistant-tb-hiv-co-infected-patients-in-kwazulu-natal-south-africa
#4
N Bionghi, A Daftary, B Maharaj, Z Msibi, K R Amico, G Friedland, C Orrell, N Padayatchi, M R O'Donnell
BACKGROUND: The introduction of Bedaquiline, the first new antimycobacterial drug in over 40 years, has highlighted the critical importance of medication adherence in drug-resistant tuberculosis (DR-TB) treatment to prevent amplified drug-resistance and derive sustained benefit. Real-time electronic dose monitoring (EDM) accurately measures adherence and allows for titration of adherence support for anti-retroviral therapy (ART). The goal of this study was to evaluate the accuracy and acceptability of a next-generation electronic pillbox (Wisepill RT2000) for Bedaquiline-containing TB regimens...
April 11, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29627424/asthma-across-the-lifespan-time-for-a-paradigm-shift
#5
Stanley J Szefler
We have a unique opportunity to significantly reduce the worldwide burden of asthma in children and impact respiratory outcomes in adults. However, this will require a paradigm shift that is directed at altering the natural history of asthma, reducing asthma exacerbations and preventing long-term adverse outcomes of childhood asthma. Attention should continue to be directed toward minimizing risk as well as impairment with a goal to achieve optimal control. Based on several NIH studies conducted over the last 10 years we now have the tools necessary to accomplish this goal...
April 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29621071/back-to-basics-adherence-with-guidelines-for-glucose-and-temperature-control-in-an-american-comprehensive-stroke-center-sample
#6
Anne W Alexandrov, Paola Palazzo, Sharon Biby, Abbigayle Doerr, Wendy Dusenbury, Rhonda Young, Anne Lindstrom, Mary Grove, Georgios Tsivgoulis, Sandy Middleton, Andrei V Alexandrov
BACKGROUND: Variance from guideline-directed care for glucose and temperature control remains unknown in the United States at a time when priorities have shifted to ensure rapid diagnosis and treatment of acute stroke patients. However, protocol-driven nursing surveillance for control of hyperglycemia and hyperthermia has been shown to improve patient outcomes. METHODS: We conducted an observational pilot study to assess compliance with American guidelines for glucose and temperature control and association with discharge outcomes in consecutive acute stroke patients admitted to 5 US comprehensive stroke centers...
April 4, 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29610111/connecting-smartphone-and-wearable-fitness-tracker-data-with-a-nationally-used-electronic-health-record-system-for-diabetes-education-to-facilitate-behavioral-goal-monitoring-in-diabetes-care-protocol-for-a-pragmatic-multi-site-randomized-trial
#7
Jing Wang, Deidra Carroll Coleman, Justin Kanter, Brad Ummer, Linda Siminerio
BACKGROUND: Mobile and wearable technology have been shown to be effective in improving diabetes self-management; however, integrating data from these technologies into clinical diabetes care to facilitate behavioral goal monitoring has not been explored. OBJECTIVE: The objective of this paper is to report on a study protocol for a pragmatic multi-site trial along with the intervention components, including the detailed connected health interface. This interface was developed to integrate patient self-monitoring data collected from a wearable fitness tracker and its companion smartphone app to an electronic health record system for diabetes self-management education and support (DSMES) to facilitate behavioral goal monitoring...
April 2, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29602631/a-randomized-trial-of-a-multicomponent-intervention-to-promote-medication-adherence-the-teen-adherence-in-kidney-transplant-effectiveness-of-intervention-trial-take-it
#8
Bethany J Foster, Ahna L H Pai, Nataliya Zelikovsky, Sandra Amaral, Lorraine Bell, Vikas R Dharnidharka, Diane Hebert, Crystal Holly, Baerbel Knauper, Douglas Matsell, Veronique Phan, Rachel Rogers, Jodi M Smith, Huaqing Zhao, Susan L Furth
BACKGROUND: Poor adherence to immunosuppressive medications is a major cause of premature graft loss among children and young adults. Multicomponent interventions have shown promise but have not been fully evaluated. STUDY DESIGN: Unblinded parallel-arm randomized trial to assess the efficacy of a clinic-based adherence-promoting intervention. SETTING & PARTICIPANTS: Prevalent kidney transplant recipients 11 to 24 years of age and 3 or more months posttransplantation at 8 kidney transplantation centers in Canada and the United States (February 2012 to May 2016) were included...
March 15, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29600595/the-tablets-ring-injections-as-options-trio-study-what-young-african-women-chose-and-used-for-future-hiv-and-pregnancy-prevention
#9
Ariane van der Straten, Kawango Agot, Khatija Ahmed, Rachel Weinrib, Erica N Browne, Kgahlisho Manenzhe, Fredrick Owino, Jill Schwartz, Alexandra Minnis
INTRODUCTION: Preventing HIV and unintended pregnancies are key global health priorities. To inform product rollout and to understand attributes of future multipurpose prevention technologies (MPT) associated with preference and use, we evaluated three placebo delivery forms: daily oral tablets, a monthly vaginal ring, and two monthly intramuscular injections in TRIO, a five-month study among young Kenyan and South African women. METHODS: HIV-negative, sexually active, non-pregnant women aged 18 to 30 were enrolled and randomized to use each placebo delivery form for one month (stage 1)...
March 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29568729/audit-of-physical-health-monitoring-in-children-and-adolescents-receiving-antipsychotics-in-neurodevelopmental-clinics-in-northumberland
#10
Sundar Gnanavel, Sharafat Hussain
AIM: To ascertain performance against the standards set by National Institute for Clinical Excellence (NICE) guidelines on physical health monitoring of thirty children and adolescents prescribed antipsychotics in neurodevelopmental clinics in Northumberland and identifying areas for improvement in practice. METHODS: The audit involved a review of recorded documentation pertaining to physical health monitoring in patient electronic records pertaining to children and adolescents attending neurodevelopmental clinics in Northumberland prescribed antipsychotics...
March 22, 2018: World Journal of Psychiatry
https://www.readbyqxmd.com/read/29556958/effectiveness-and-safety-of-oral-anticoagulants-in-patients-with-sickle-cell-disease-and-venous-thromboembolism-a-retrospective-cohort-study
#11
Megan Z Roberts, G Eric Gaskill, Julie Kanter-Washko, T Rogers Kyle, Brittany C Jones, Nicole M Bohm
Patients with sickle cell disease (SCD) experience initial and recurrent venous thromboembolism (VTE) more commonly and at a younger age than the general population, and it confers a higher mortality for patients with SCD. However, limited evidence is available to guide anticoagulant use for VTE treatment in this population. The primary objective of this study is to characterize the effectiveness and safety of direct oral anticoagulants (DOAC) and warfarin for VTE treatment among patients with SCD. This single-center retrospective study includes adult patients with SCD who were diagnosed with VTE...
March 19, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29550683/simultaneous-determination-of-antiretroviral-drugs-in-human-hair-with-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry
#12
Yan Wu, Jin Yang, Cailing Duan, Liuxi Chu, Shenghuo Chen, Shan Qiao, Xiaoming Li, Huihua Deng
The determination of the concentrations of antiretroviral drugs in hair is believed to be an important means for the assessment of the long-term adherence to highly active antiretroviral therapy. At present, the combination of tenofovir, lamivudine and nevirapine is widely used in China. However, there was no research reporting simultaneous determination of the three drugs in hair. The present study aimed to develop a sensitive method for simultaneous determination of the three drugs in 2-mg and 10-mg natural hair (Method 1 and Method 2)...
March 11, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29534793/a-competitive-lateral-flow-assay-for-the-detection-of-tenofovir
#13
George W Pratt, Andy Fan, Bissrat Melakeberhan, Catherine M Klapperich
Proper management of an HIV infection requires that a patient be at least 80-95% adherent to a prescribed drug regimen to avoid poor health outcomes and the development of drug-resistant HIV strains. Clinicians generally monitor adherence habits indirectly through patient self-reporting, pill counting, and electronic drug monitoring. While direct measurement of patient samples like urine for monitoring drug levels is possible, it requires specialized equipment and training that is not readily available in resource-limited settings where the need is greatest...
August 9, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29519922/non-adherence-in-the-era-of-severe-asthma-biologics-and-thermoplasty
#14
Joy Lee, Tunn Ren Tay, Naghmeh Radhakrishna, Fiona Hore-Lacy, Anna Mackay, Ryan Hoy, Eli Dabscheck, Robyn O'Hehir, Mark Hew
Non-adherence to inhaled preventers impairs asthma control. Electronic monitoring devices (EMD) can objectively measure adherence. Their use has not been reported in difficult asthma patients potentially suitable for novel therapies, i.e. biologics and bronchial thermoplasty.Consecutive patients with difficult asthma were assessed for eligibility for novel therapies. Medication adherence, defined as taking 75% or more of prescribed doses, was assessed by EMD and compared to standardised clinician assessment over an eight week period...
March 8, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29511850/using-information-technology-in-the-assessment-and-monitoring-of-geriatric-oncology-patients
#15
REVIEW
Kah Poh Loh, Colin McHugh, Supriya G Mohile, Karen Mustian, Marie Flannery, Heidi Klepin, Rebecca Schnall, Eva Culakova, Erika Ramsdale
PURPOSE OF REVIEW: Older adults with cancer have complex medical needs and often experience higher rates of treatment-related toxicities compared to their younger counterparts. The advent of health information technologies can address multiple gaps in the care of this population. We review the role of existing and emerging technologies in facilitating the use of comprehensive geriatric assessment (CGA) in routine clinics, promoting symptom reporting, and monitoring medication adherence...
March 6, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29510813/electronic-monitoring-in-bipolar-disorder
#16
Maria Faurholt-Jepsen
Major reasons for the insufficient effects of current treatment options in bipolar disorder include delayed intervention for prodromal depressive and manic symptoms and decreased adherence to psychopharmacological treatment. The reliance on subjective information and clinical evaluations when diagnosing and assessing the severity of depressive and manic symptoms calls for less biased and more objective markers. By using electronic devices, fine-grained data on complex psychopathological aspects of bipolar disorder can be evaluated unobtrusively over the long term...
March 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29487598/macrophages-in-the-human-cochlea-saviors-or-predators-a-study-using-super-resolution-immunohistochemistry
#17
Wei Liu, Matyas Molnar, Carolyn Garnham, Heval Benav, Helge Rask-Andersen
The human inner ear, which is segregated by a blood/labyrinth barrier, contains resident macrophages [CD163, ionized calcium-binding adaptor molecule 1 (IBA1)-, and CD68-positive cells] within the connective tissue, neurons, and supporting cells. In the lateral wall of the cochlea, these cells frequently lie close to blood vessels as perivascular macrophages. Macrophages are also shown to be recruited from blood-borne monocytes to damaged and dying hair cells induced by noise, ototoxic drugs, aging, and diphtheria toxin-induced hair cell degeneration...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29466334/skin-electronics-from-scalable-fabrication-of-an-intrinsically-stretchable-transistor-array
#18
Sihong Wang, Jie Xu, Weichen Wang, Ging-Ji Nathan Wang, Reza Rastak, Francisco Molina-Lopez, Jong Won Chung, Simiao Niu, Vivian R Feig, Jeffery Lopez, Ting Lei, Soon-Ki Kwon, Yeongin Kim, Amir M Foudeh, Anatol Ehrlich, Andrea Gasperini, Youngjun Yun, Boris Murmann, Jeffery B-H Tok, Zhenan Bao
Skin-like electronics that can adhere seamlessly to human skin or within the body are highly desirable for applications such as health monitoring, medical treatment, medical implants and biological studies, and for technologies that include human-machine interfaces, soft robotics and augmented reality. Rendering such electronics soft and stretchable-like human skin-would make them more comfortable to wear, and, through increased contact area, would greatly enhance the fidelity of signals acquired from the skin...
February 19, 2018: Nature
https://www.readbyqxmd.com/read/29447360/allocation-of-treatment-responsibility-in-adolescents-with-epilepsy-associations-with-cognitive-skills-and-medication-adherence
#19
Christina E Holbein, Aimee W Smith, James Peugh, Avani C Modi
Objectives: To describe allocation of treatment responsibility (ATR) in adolescents with epilepsy, investigate associations between cognitive skills and ATR, and examine whether ATR for antiepileptic drugs (AEDs) predicted electronically monitored adherence. Method: Sixty adolescents with epilepsy and their caregivers completed the Allocation of Treatment Responsibility Scale and a battery of self-report measures. Medical chart review data and electronically monitored AED adherence were collected for 1 year...
February 13, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29442516/engineering-nitroxide-functional-surfaces-using-bioinspired-adhesion
#20
Hendrik Woehlk, Jan Steinkoenig, Christiane Lang, Lukas Michalek, Vanessa Trouillet, Peter Krolla-Sidenstein, Anja S Goldmann, Leonie Barner, James P Blinco, Christopher Barner-Kowollik, Kathryn E Fairfull-Smith
We pioneer a versatile surface modification strategy based on mussel inspired oxidative catecholamine polymerization for the design of nitroxide containing thin polymer films. A 3,4-dihydroxy-L-phenylalanine (L-DOPA) monomer equipped with a 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) derived oxidation-labile hydroxylamine functional group is employed as a universal coating agent to generate polymer scaffolds with persistent radical character. Various types of materials including silicon, titanium, ceramic alumina and inert poly(tetrafluoroethylene) (PTFE) were successfully coated with poly(DOPA-TEMPO) thin films in a one-step dip-coating procedure under aerobic, slightly alkaline (pH 8...
February 14, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
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