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https://www.readbyqxmd.com/read/29755756/treatment-choice-medication-adherence-and-glycemic-efficacy-in-people-with-type-2-diabetes-a-uk-clinical-practice-database-study
#1
Jason Gordon, Phil McEwan, Iskandar Idris, Marc Evans, Jorge Puelles
Objective: Using primary care data obtained from the UK Clinical Practice Research Datalink, this retrospective cohort study examined the relationships between medication adherence and clinical outcomes in patients with type 2 diabetes. Research design and methods: Data were extracted for patients treated between 2008 and 2016, and stratified by oral antihyperglycemic agent (OHA) line of therapy (mono, dual or triple therapy). Patients were monitored for up to 365 days; associations between medication possession ratio (MPR) and outcomes at 1 year (glycated hemoglobin A1c (HbA1c), weight and hypoglycemia incidence) were assessed using linear regression modeling and descriptive analyses...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29744822/study-protocol-for-the-initial-choice-of-dpp-4-inhibitor-in-japanese-patients-with-type-2-diabetes-mellitus-effect-of-linagliptin-on-qol-intel-qol-trial
#2
Tomoya Mita, Toru Hiyoshi, Hidenori Yoshii, Hiroko Chimori, Kazuo Ikeda, Junko Sato, Hirotaka Watada
INTRODUCTION: Consideration of treatment-related quality of life (QOL) is important in diabetes management. However, no studies have compared the influence of dipeptidyl peptidase-4 inhibitors versus metformin on treatment-related QOL when used as first-line therapy in patients with type 2 diabetes mellitus. METHODS: This study is a prospective, randomized, open-label, multicenter, parallel-group, comparative study. Between June 2016 and December 2017, 44 participants who failed to achieve glycemic control despite diet and exercise therapy were recruited at 14 clinics and randomly allocated to linagliptin or metformin therapy...
May 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29726577/insulin-degrading-enzyme-is-up-regulated-in-pancreatic-_cells-by-insulin-treatment
#3
Cristina M Fernández-Díaz, Luis Escobar-Curbelo, J F López-Acosta, Carmen D Lobatón, Alfredo Moreno, Julián Sanz-Ortega, Germán Perdomo, Irene Cózar-Castellano
Insulin Degrading Enzyme (IDE) is an endopeptidase that degrades insulin and glucagon. Ide gene has been associated with type-2 diabetes mellitus (DM2). However, the physiological role(s) of IDE in glucose homeostasis and its potential therapeutic benefit remain not completely known. To contribute in the understanding of IDE's role in glucose metabolism, we analyzed IDE protein level in pancreatic islets from two hyperinsulinemic mouse models, db/db and high-fat diet (HFD) mice, as well as in human islets from DM2 patients treated with oral hypoglycemic agents (OHAs) or insulin...
May 4, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29718952/women-are-less-likely-than-men-to-achieve-optimal-glycemic-control-after-1-year-of-treatment-a-multi-level-analysis-of-a-korean-primary-care-cohort
#4
Seung-Ah Choe, Joo Yeong Kim, Young Sun Ro, Sung-Il Cho
We investigated differences in the achievement of glycemic control among newly diagnosed type-2 diabetes patients according to gender using a multi-clinic retrospective cohort study. Optimal glycemic control was defined as hemoglobin A1c (HbA1c) of less than 6.5% after 1 year of diabetes management. A generalized linear mixed model, which controlled for the fixed effects of baseline characteristics and prescribed oral hypoglycemic agent (OHA), was used to calculate the probability of achieving the target HbA1c...
2018: PloS One
https://www.readbyqxmd.com/read/29589805/hyaluronan-impairs-the-barrier-integrity-of-brain-microvascular-endothelial-cell-through-a-cd44-dependent-pathway
#5
Abraham J Al-Ahmad, Ronak Patel, Sean P Palecek, Eric V Shusta
Hyaluronan (HA) constitutes the most abundant extracellular matrix component during brain development, only to become a minor component rapidly after birth and in adulthood to remain in specified regions. HA signaling has been associated with several neurological disorders, yet the impact of HA signaling at the blood-brain barrier (BBB) function remains undocumented. In this study, we investigated the impact of HA on BBB properties using human-induced pluripotent stem cell (iPSC) -derived and primary human and rat BMECs...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29532114/peri-operative-complications-of-lumbar-spine-surgery-in-patients-over-eighty-five-years-of-age-a-retrospective-cohort-study
#6
Shingo Onda, Masahiro Kanayama, Tomoyuki Hashimoto, Fumihiro Oha, Akira Iwata, Masaru Tanaka, Kazuo Kaneko
PURPOSE: To compare peri-operative complication rates in ≥ 85-year-old patients who underwent decompression surgery with or without instrumented fusion for degenerative disorders. METHODS: This study involved 907 patients who underwent lumbar spine surgery for degenerative disorders between January 2006 and June 2012. Of these, 33 patients (3.6% of the entire population) were over 85 years of age (85-94 years). Decompression-alone and instrumentation groups were compared in terms of comorbidities, American Society of Anesthesiologists (ASA)-physical status (PS) class, peri-operative complications, and Japanese Orthopedic Association (JOA) scores...
May 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29524188/adverse-drug-events-associated-with-low-dose-10-mg-versus-high-dose-25-mg-empagliflozin-in-patients-treated-for-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#7
Xia Dai, Zu-Chun Luo, Lu Zhai, Wen-Piao Zhao, Feng Huang
INTRODUCTION: Empagliflozin is a new, emerging oral hypoglycemic agent (OHA) which has shown significant benefits in type 2 diabetes mellitus (T2DM) patients with cardiovascular disease. In this analysis, our aim was to systematically compare the adverse drug events (ADEs) associated with a low (10 mg) versus a high (25 mg) dose of empagliflozin as (1) monotherapy, (2) as an add-on to other OHAs, and (3) as an add-on specifically to metformin, in patients who were treated for T2DM. METHODS: This was a systematic review and meta-analysis of randomized controlled trials that compared empagliflozin 10 mg versus 25 mg in patients who were treated for T2DM and which reported adverse drug reactions as their clinical endpoints...
April 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29507611/dapagliflozin-improves-treatment-satisfaction-in-overweight-patients-with-type-2-diabetes-mellitus-a-patient-reported-outcome-study-pro-study
#8
Hiroki Nakajima, Sadanori Okada, Takako Mohri, Eiichiro Kanda, Naoyuki Inaba, Yoko Hirasawa, Hiroaki Seino, Hisamoto Kuroda, Toru Hiyoshi, Tetsuji Niiya, Hitoshi Ishii
Background: The benefits of sodium glucose cotransporters 2 (SGLT2) inhibitors in patients with type 2 diabetes mellitus include plasma glucose control, reduction in body weight and blood pressure, and low risk of hypoglycemia, although they may also cause genitourinary infections, polyuria, or volume depletion. It is not clear whether dapagliflozin, an SGLT2 inhibitor, improves treatment satisfaction among patients in a comprehensive way despite the negative side effects. This study assessed the effect of dapagliflozin on glycosylated hemoglobin (HbA1c), body weight, and treatment satisfaction in overweight patients with type 2 diabetes mellitus treated with oral hypoglycemic agents...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29463371/enhanced-in-vitro-and-in-vivo-anticancer-properties-by-using-a-nanocarrier-for-co-delivery-of-antitumor-polypeptide-and-curcumin
#9
Mengjiao Qi, Shaohua Zou, Chunjing Guo, Kaili Wang, Yueming Yu, Feng Zhao, Huaying Fan, Zimei Wu, Wanhui Liu, Daquan Chen
In this paper, a novel pH and redox dual-sensitive nanocarrier loaded with curcumin (Cur) and anticancer polypeptide (AP) was developed for dual targeting mitochondrial and CD44 receptor. The amphiphilic block copolymer was prepared by triphenylphosphonium (TPP)/oligomeric hyaluronic acid (oHA)/disulfide-menthone 1,2-glycerol ketal (SM), hereinafter referred to as TPP-oHSM. The TPP targeted the mitochondria, pH/redox dual-sensitive SM served as a hydrophobic part, and the CD44 receptor targeting oHA worked as a hydrophilic part...
January 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29430413/an-evaluation-of-the-impact-of-antidiabetic-medication-on-treatment-satisfaction-and-quality-of-life-in-patients-of-diabetes-mellitus
#10
Richa Chaturvedi, Chetna Desai, Prakruti Patel, Asha Shah, Ram K Dikshit
Aims: This study aims to measure the quality of life (QOL), treatment satisfaction, and tolerability of antidiabetic drugs in patients suffering from type 2 diabetes mellitus (DM). Methods: The prospective, observational study was conducted in consenting patients of type 2 DM attending the outpatient department of a tertiary care hospital in Western India. The QOL instrument for Indian diabetes (QOLID) patients questionnaire and the Diabetes Treatment Satisfaction Questionnaire were administered to all patients at baseline, 3 months, and 6 months of treatment...
January 2018: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/29402019/tailored-raman-resonant-four-wave-mixing-processes
#11
C Ohae, J Zheng, K Ito, M Suzuki, K Minoshima, M Katsuragawa
Nonlinear optical processes are strongly dominated by phase relationships among electromagnetic fields involved. In this paper, we theoretically and experimentally show that in a Raman-resonant four-wave-mixing process, the first anti-Stokes and Stokes generations can be tailored in a variety of ways by manipulating the phase relationships among the relevant electromagnetic fields.
January 22, 2018: Optics Express
https://www.readbyqxmd.com/read/29400583/glycol-chitosan-oxidized-hyaluronic-acid-hydrogels-functionalized-with-cartilage-extracellular-matrix-particles-and-incorporating-bmscs-for-cartilage-repair
#12
Chun Liu, Deshuai Liu, Yingying Wang, Yun Li, Tao Li, Zhiyou Zhou, Zhijian Yang, Jianhua Wang, Qiqing Zhang
In this article, we fabricated a bioactive hydrogel composed of glycol chitosan (G-CS) and oxidized hyaluronic acid (OHA) via Schiff base reaction. Cartilage extracellular matrix (ECM) particles with different concentrations were used to functionalize G-CS/OHA (S1) hydrogel. The results demonstrated that S3 (G-CS/OHA/ECM 2% w/v) hydrogel exhibited the most suitable compression strength and provided the optimal environment for proliferation of bone marrow mesenchymal stem cells (BMSCs). To assess the chondroinductivity of ECM in vitro, we compared the chondrogenesis of BMSCs in S1 (G-CS/OHA) and S3 (G-CS/OHA/ECM 2% w/v) hydrogels...
February 5, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29396830/novel-dual-mitochondrial-and-cd44-receptor-targeting-nanoparticles-for-redox-stimuli-triggered-release
#13
Kaili Wang, Mengjiao Qi, Chunjing Guo, Yueming Yu, Bingjie Wang, Lei Fang, Mengna Liu, Zhen Wang, Xinxin Fan, Daquan Chen
In this work, novel mitochondrial and CD44 receptor dual-targeting redox-sensitive multifunctional nanoparticles (micelles) based on oligomeric hyaluronic acid (oHA) were proposed. The amphiphilic nanocarrier was prepared by (5-carboxypentyl)triphenylphosphonium bromide (TPP), oligomeric hyaluronic acid (oHA), disulfide bond, and curcumin (Cur), named as TPP-oHA-S-S-Cur. The TPP targeted the mitochondria, the antitumor drug Cur served as a hydrophobic core, the CD44 receptor targeting oHA worked as a hydrophilic shell, and the disulfide bond acted as a connecting arm...
February 2, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29331780/application-of-octanohydroxamic-acid-for-liquid-liquid-extraction-of-manganese-oxides-and-fabrication-of-supercapacitor-electrodes
#14
J Milne, I Zhitomirsky
MnO2 and Mn3 O4 particles were prepared by wet chemical methods and efficiently dispersed and mixed with multiwalled carbon nanotubes (MWCNT) for the fabrication of composite MnO2 -MWCNT and Mn3 O4 -MWCNT electrodes for electrochemical supercapacitors (ES). The problem of particle agglomeration was addressed by particle extraction through a liquid-liquid interface (PELLI) using octanohydroxamic acid (OHA) as a new extractor. OHA exhibited remarkable adsorption on particles due to a bidentate bonding mechanism...
April 1, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29306889/physician-engagement-in-hospitals-a-scoping-review-protocol
#15
Tyrone Perreira, Laure Perrier, Melissa Prokopy, Anthony Jonker
INTRODUCTION: Literature on healthcare reforms highlights the importance of physician engagement, suggesting that it is a critical factor for lowering costs while improving efficiency, quality of care, patient safety, physician satisfaction and retention. As a result, many hospitals have adopted physician engagement as a top strategic priority, but little is known about the actual evidence, making it difficult for hospital leadership to identify relationships between true physician 'work engagement' and work outcomes...
January 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29278711/self-efficacy-self-care-and-glycemic-control-in-saudi-arabian-patients-with-type-2-diabetes-mellitus-a-cross-sectional-survey
#16
Ahmad M J Saad, Zeina M H Younes, Hafez Ahmed, Jason A Brown, Rafat M Al Owesie, Ahmed A K Hassoun
AIMS: To determine the prevalence of diabetes self-care activities among type 2 diabetes patients and examine the association between socio-demographic and clinical parameters, diabetes self-care activities, and glycemic control among type 2 diabetes patients. METHODS: A cross sectional study was conducted among patients with diabetes (n = 123) at the Sultan Bin Abdulaziz Humanitarian City (SBAHC). A regression model was used to examine the variables that predicted glycemic control...
December 24, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29239219/multifunctional-redox-responsive-and-cd44-receptor-targeting-polymer-drug-nanomedicine-based-curcumin-and-alendronate-synthesis-characterization-and-in-vitro-evaluation
#17
Xue Dong, Shaohua Zou, Chunjing Guo, Kaili Wang, Feng Zhao, Huaying Fan, Jungang Yin, Daquan Chen
The traditional therapy of cancer has systemic side effects, and many cancers, such as human breast cancer and lung cancer easily metastasize to bones, leading to the formation of secondary tumours. This study was aimed at enhancing the anti-tumour effect of curcumin (CUR) and preventing tumour spread to the bone. A novel multifunctional redox-responsive and CD44 receptor targeting polymer-drug, poly alendronate-hyaluronan-S-S-curcumin copolymer (ALN-oHA-S-S-CUR) based CUR and alendronate (ALN) were synthesized successfully with the disulphide bond linker...
December 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29230931/temporal-changes-in-glycaemic-thresholds-for-treatment-intensification-in-type-2-diabetes-in-an-urban-australian-setting-the-fremantle-diabetes-study
#18
Timothy M E Davis, Stephen A P Chubb, Bradley H Curtis, Helen Barraclough, Wendy A Davis
BACKGROUND: Pharmacotherapy and supportive care for diabetes in Australia are improving, with potential beneficial effects on therapeutic procrastination. AIMS: To determine whether glycaemic thresholds for therapeutic intensification in type 2 diabetes changed over the 15 years between Phases of the community-based Fremantle Diabetes Study (FDS). METHODS: We studied 531 Phase 1 participants (mean age 62.4 years, 54.2% males, median diabetes duration 3...
December 12, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29200880/estimating-the-risk-of-severe-hypoglycemic-event-related-to-glucose-lowering-treatment-among-italian-patients-with-diabetes-the-hypothesis-database
#19
Silvio Mazzi, Roberto Ravasio, Gabriele Forlani, Giacomo Veronese, Andrea Fabbri, Giulio Marchesini
The primary objective of this study was to estimate 1) the annual risk of undergoing a severe hypoglycemic event in Italian patients with diabetes and 2) the risk of hospitalization following such event. From the HYPOTHESIS database, powered by 46 emergency departments covering a 12-million-odd population, data were extracted of 1,922 hypoglycemic events occurring in patients with diabetes in 2011. The mean age was 71.5 (standard deviation 16.8) years, 50.1% were men, and blood glucose at the time of the event was 44...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29096431/combination-therapy-of-oral-hypoglycemic-agents-in-patients-with-type-2-diabetes-mellitus
#20
REVIEW
Min Kyong Moon, Kyu Yeon Hur, Seung-Hyun Ko, Seok-O Park, Byung-Wan Lee, Jin Hwa Kim, Sang Youl Rhee, Hyun Jin Kim, Kyung Mook Choi, Nan-Hee Kim
The Korean Diabetes Association (KDA) recently updated the Clinical Practice Guidelines on antihyperglycemic agent therapy for adult patients with type 2 diabetes mellitus (T2DM). In combination therapy of oral hypoglycemic agents (OHAs), general recommendations were not changed from those of the 2015 KDA guidelines. The Committee on Clinical Practice Guidelines of the KDA has extensively reviewed and discussed the results of meta-analyses and systematic reviews of effectiveness and safety of OHAs and many clinical trials on Korean patients with T2DM for the update of guidelines...
November 2017: Korean Journal of Internal Medicine
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