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S K Sharma, S H Verma
OBJECTIVES: To study the complete fasting lipid profile and other parameters (weight, body mass index, HbA1c, fasting blood sugar and postprandial blood sugar)in Type 2 diabetes mellitus patients on OHA/insulin, to study the effect of addition of pioglitazone on lipid profile and other parameters in Type 2 diabetes mellitus patients on OHA/insulin, to study the effect of addition of rosiglitazone on lipid profile and other parameters in Type 2 diabetes mellitus patients on OHA/insulin and to compare the effect of pioglitazone and rosiglitazone on lipid profile and other parameters in Type 2 diabetes mellitus patients on OHA/insulin...
September 2016: Journal of the Association of Physicians of India
B S Bal, Ashok Duggal, Mandeep Kaur, Umar Farooq, Harman Preet Singh
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Sin Gon Kim, Nam Hoon Kim, Bon Jeong Ku, Ho Sang Shon, Doo Man Kim, Tae Sun Park, Yong-Seong Kim, In Joo Kim, Dong Seop Choi
AIMS/INTRODUCTION: To assess the time to initiation of insulin therapy and concurrently investigate both patient- and physician-related factors associated with delaying insulin therapy in Korean patients with type 2 diabetes (T2D) uncontrolled on oral hypoglycemic agents (OHAs). MATERIALS AND METHODS: This prospective, observational disease registry study was conducted across 69 centers in Korea. T2D patients who had received two or more OHAs within the last 5 years, had a glycated hemoglobin (HbA1c) ≥8% in the last 6 months, and had not received insulin were included...
October 6, 2016: Journal of Diabetes Investigation
Po-Jen Hsiao, Kun-Lin Wu, Szu-Han Chiu, Jenq-Shyong Chan, Yuh-Feng Lin, Chung-Ze Wu, Chia-Chao Wu, SenYeong Kao, Te-Chao Fang, Shih-Hua Lin, Jin-Shuen Chen
BACKGROUND: Type 2 diabetes mellitus (DM) and associated complications are common in patients with chronic kidney disease (CKD) and can increase morbidity and mortality. A longitudinal 5-year observational study was conducted to investigate whether the use of anti-diabetic medications or not affected survival rates of diabetic dialysis patients. METHODS: Using a data sample of a million patients from Taiwan's National Health Insurance Database, a retrospective cohort study surveyed patients with type 2 DM who began dialysis between 2002 and 2007...
September 6, 2016: Clinical and Experimental Nephrology
Gyuri Kim, Yong Ho Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Byung Wan Lee
PURPOSE: The objective of this study was to investigate clinical and laboratory parameters that could predict which patients could maintain adequate glycemic control after switching from initial insulin therapy to oral hypoglycemic agents (OHAs) among patients with type 2 diabetes (T2D). MATERIALS AND METHODS: We recruited 275 patients with T2D who had been registered in 3 cohorts of initiated insulin therapy and followed up for 33 months. The participants were divided into 2 groups according to whether they switched from insulin to OHAs (Group I) or not (Group II), and Group I was further classified into 2 sub-groups: maintenance on OHAs (Group IA) or resumption of insulin (Group IB)...
November 2016: Yonsei Medical Journal
Abhijit A Ghadge, Aniket A Kuvalekar
AIM: As diabetes mellitus is multi-factorial disease, use of several oral hypoglycemic agents (OHAs) is the main stay of pharmacological treatment. The treatment has become more challenging and controversial as OHAs are heterogeneous in their mode of action that causes unwanted side effects. Complementary approaches such as use of medicinal plants and dietary polyunsaturated fatty acids (PUFA) with hypoglycemic and hypolipidemic activities are therefore imperative. A vast literature has independently documented the effects of OHAs, medicinal plants and PUFA for management of diabetes...
August 22, 2016: Diabetes & Metabolic Syndrome
Akira Iwata, Masahiro Kanayama, Fumihiro Oha, Tomoyuki Hashimoto, Norimasa Iwasaki
PURPOSE: In the healing of osteoporotic vertebral fracture, global spinal mal-alignment might increase the load sharing at the fracture site and deteriorate the fracture healing. This study aimed to evaluate the effect of spinopelvic alignment on the union status of thoracolumbar osteoporosis-related vertebral compression fracture (OVCF). METHODS: Consecutive 48 patients with a single-level thoracolumbar fresh OVCF were treated non-operatively. Union was judged by three independent observers at 6 months, and patients were divided into union group and non-union group...
August 30, 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Makito Tanabe, Ryoko Motonaga, Yuichi Terawaki, Takashi Nomiyama, Toshihiko Yanase
INTRODUCTION: In treatment algorithms of type-2 diabetes mellitus (T2DM) in Western countries, biguanides are recommended as first-line agents. In Japan, various oral hypoglycemic agents (OHAs) are available, but prescription patterns are unclear. MATERIALS AND METHODS: Data of 7,108 and 2,655 T2DM patients in study-1 and -2, respectively, were extracted from the MDV database (2008-2013). Cardiovascular disease (CVD) history was not considered in study-1, but was in study-2...
August 23, 2016: Journal of Diabetes Investigation
Kristi Reynolds, JaeJin An, Jun Wu, Teresa N Harrison, Rong Wei, Bruce Stuart, John P Martin, Catherine S Wlodarczyk, Swapnil N Rajpathak
AIMS: To investigate the discontinuation of oral antihyperglycemic agents (OHA), and examine factors associated with OHA discontinuation, and the effect of OHA discontinuation on glycemic control and healthcare utilization among diabetes patients prescribed dual OHA therapy. METHODS: We identified 23,612 adult patients aged >18years with a diagnosis of type 2 diabetes who initiated dual OHA therapy between 1/1/2005 and 6/30/2010. The date of initiation of the second OHA was defined as the index date...
November 2016: Journal of Diabetes and its Complications
Riyas Basheer, Muhammed Jasim Abdul Jalal, Ramesh Gomez
Prader-Willi syndrome (PWS) is a complex genetic disorder, characterized by neonatal hypotonia, developmental delay, short stature, childhood obesity, hypogonadism, and characteristic facial features. Here we report a 21-year-old male who presented with uncontrolled glycemic status. He was diagnosed to have diabetes mellitus at the age of 15 with osmotic symptoms - polyuria, polydipsia, and polyphagia. In the early period, after diagnosis, his blood sugars were reasonably controlled with oral hypoglycemic agents...
January 2016: Journal of Family Medicine and Primary Care
Trivikramarao Gavara, Takeru Ohashi, Yusuke Sasaki, Takuya Kawashima, Hiroaki Hamano, Ryo Yoshizaki, Yuki Fujimura, Kazumichi Yoshii, Chiaki Ohae, Masayuki Katsuragawa
We report a dual-frequency injection-locked continuous-wave near-infrared laser. The entire system consists of a Ti:sapphire ring laser as a power oscillator, two independent diode lasers employed as seed lasers, and a master cavity providing a frequency reference. Stable dual-frequency injection-locked oscillation is achieved with a maximum output power of 2.8 W. We show its single longitudinal/transverse mode characteristics and practical power stability, as fundamental performance features of this laser system...
July 1, 2016: Optics Letters
Bruce Stuart, Franklin Hendrick, Jing Xu, J Samantha Dougherty
OBJECTIVES: To determine the magnitude and mechanisms of response to Medicare Part D cost sharing by low-income subsidy (LIS) recipients using oral hypoglycemic agents (OHAs) and statins. DATA SOURCES: Medicare data for a 5 percent random sample of beneficiaries with diabetes enrolled in fee-for-service Part D drug plans in 2008. STUDY DESIGN: We evaluated the impact of differences between generic and brand cost sharing rates among cohorts of LIS and non-LIS recipients to determine if wider price spreads increased the generic dispensing rate (GDR) and reduced total drug use and cost...
June 20, 2016: Health Services Research
Thewjitcharoen Yotsapon, Krittiyawong Sirinate, Wanothayaroj Ekgaluck, Vongterapak Somboon, Anuntakulnatee Tawee, Kittipoom Worawit, Nakasatien Soontaree, Himathongkam Thep
BACKGROUND: Advance in medicine has led to an increase in life expectancy of elderly diabetic patients especially on the growing population called the "oldest old", those in their mid-80s upwards. The aim of this study is to describe clinical characteristics and outcomes of "oldest old" patients in a specialized diabetes center. METHODS: A retrospective review was conducted on medical records of type 2 diabetes who were older than 85 years at Theptarin hospital from September 2014 to August 2015...
2016: BMC Endocrine Disorders
Ya Liu, Fang-Qin Wang, Zeana Shah, Xiao-Jie Cheng, Ming Kong, Chao Feng, Xi-Guang Chen
Here we described nano-polyplexes (NPs) made of oleoyl-carboxymethy-chitosan (OCMCS)/hyaluronic acid (HA) as novel potential carriers for oral gene vaccines delivery. Aerolysin gene (aerA) of Aeromonas hydrophila as microbial antigen was efficiently loaded to form OCMCS-HA/aerA (OHA) NPs. OHA NPs performed the optimal parameters, i.e. smallest (154.5±9.4nm), positive charged (+7.9±0.5mV) and monodispersed system with the N/P ratio of 5 and OCMCS/HA weight ratio of 4. Upon the introduction of HA, OHA NPs was beneficial for the DNA release in intestinal environments in comparison to OA NPs...
September 1, 2016: Colloids and Surfaces. B, Biointerfaces
Mingyan Zhao, George Altankov, Urszula Grabiec, Mark Bennett, Manuel Salmeron-Sanchez, Faramarz Dehghani, Thomas Groth
UNLABELLED: The effect of molecular composition of multilayers, by pairing type I collagen (Col I) with either hyaluronic acid (HA) or chondroitin sulfate (CS) was studied regarding the osteogenic differentiation of adhering human adipose-derived stem cells (hADSCs). Polyelectrolyte multilayer (PEM) formation was based primarily on ion pairing and on additional intrinsic cross-linking through imine bond formation with Col I replacing native by oxidized HA (oHA) or CS (oCS). Significant amounts of Col I fibrils were found on both native and oxidized CS-based PEMs, resulting in higher water contact angles and surface potential under physiological condition, while much less organized Col I was detected in either HA-based multilayers, which were more hydrophilic and negatively charged...
September 1, 2016: Acta Biomaterialia
Sergio Vargas-Prada, David Coggon, Georgia Ntani, Karen Walker-Bone, Keith T Palmer, Vanda E Felli, Raul Harari, Lope H Barrero, Sarah A Felknor, David Gimeno, Anna Cattrell, Matteo Bonzini, Eleni Solidaki, Eda Merisalu, Rima R Habib, Farideh Sadeghian, M Masood Kadir, Sudath S P Warnakulasuriya, Ko Matsudaira, Busisiwe Nyantumbu, Malcolm R Sim, Helen Harcombe, Ken Cox, Leila M M Sarquis, Maria H Marziale, Florencia Harari, Rocio Freire, Natalia Harari, Magda V Monroy, Leonardo A Quintana, Marianela Rojas, E Clare Harris, Consol Serra, J Miguel Martinez, George Delclos, Fernando G Benavides, Michele Carugno, Marco M Ferrario, Angela C Pesatori, Leda Chatzi, Panos Bitsios, Manolis Kogevinas, Kristel Oha, Tiina Freimann, Ali Sadeghian, Roshini J Peiris-John, Nalini Sathiakumar, A Rajitha Wickremasinghe, Noriko Yoshimura, Helen L Kelsall, Victor C W Hoe, Donna M Urquhart, Sarah Derrett, David McBride, Peter Herbison, Andrew Gray, Eduardo J Salazar Vega
Somatising tendency, defined as a predisposition to worry about common somatic symptoms, is importantly associated with various aspects of health and health-related behaviour, including musculoskeletal pain and associated disability. To explore its epidemiological characteristics, and how it can be specified most efficiently, we analysed data from an international longitudinal study. A baseline questionnaire, which included questions from the Brief Symptom Inventory about seven common symptoms, was completed by 12,072 participants aged 20-59 from 46 occupational groups in 18 countries (response rate 70%)...
2016: PloS One
Young-Seok Seo, Yun-Jung Kim, Mi-Sook Kim, Kyung-Suk Suh, Sang Bum Kim, Chul Ju Han, Youn Joo Kim, Won Il Jang, Shin Hee Kang, Ha Jin Tchoe, Chan Mi Park, Ae Jung Jo, Hyo Jeong Kim, Jin A Choi, Hyung Jin Choi, Michael N Polak, Min Jung Ko
Many preclinical reports and retrospective population studies have shown an anticancer effect of metformin in patients with several types of cancer and comorbid type 2 diabetes mellitus (T2DM). In this work, the anticancer effect of metformin was assessed in hepatocellular carcinoma (HCC) patients with T2DM who underwent curative resection.A population-based retrospective cohort design was used. Data were obtained from the National Health Insurance Service and Korea Center Cancer Registry in the Republic of Korea, identifying 5494 patients with newly diagnosed HCC who underwent curative resection between 2005 and 2011...
April 2016: Medicine (Baltimore)
Yukiko Matsushima, Yumie Takeshita, Yuki Kita, Toshiki Otoda, Ken-Ichiro Kato, Hitomi Toyama-Wakakuri, Hiroshi Akahori, Akiko Shimizu, Erika Hamaguchi, Yasuyuki Nishimura, Takehiro Kanamori, Shuichi Kaneko, Toshinari Takamura
PURPOSE: A step-up strategy for diet therapy and/or single oral antihyperglycemic agent (OHA) regimens has not yet been established. The aim of this study was to evaluate hemoglobin A1c (HbA1c) as a primary end point, and the pleiotropic effects on metabolic and cardiovascular parameters as secondary end points, of sitagliptin versus voglibose in patients with type 2 diabetes with inadequate glycemic control while on diet therapy and/or treatment with a single OHA. METHODS: In this multicenter, randomized, open-label, parallel-group trial, a total of 260 patients with inadequately controlled type 2 diabetes (HbA1c levels >6...
2016: BMJ Open Diabetes Research & Care
Adem Yesuf Dawed, Kaixin Zhou, Ewan Robert Pearson
Type 2 diabetes is one of the leading causes of morbidity and mortality, consuming a significant proportion of public health spending. Oral hypoglycemic agents (OHAs) are the frontline treatment approaches after lifestyle changes. However, huge interindividual variation in response to OHAs results in unnecessary treatment failure. In addition to nongenetic factors, genetic factors are thought to contribute to much of such variability, highlighting the importance of the potential of pharmacogenetics to improve therapeutic outcome...
2016: Pharmacogenomics and Personalized Medicine
Ali Muhsen Ali, Mia Burleigh, Evangelia Daskalaki, Tong Zhang, Chris Easton, David G Watson
Ten physically active subjects underwent two cycling exercise trials. In the first, aerobic capacity (VO2max) was determined and the second was a 45 min submaximal exercise test. Urine samples were collected separately the day before (day 1) , the day of (day 2), and the day after (day 3) the submaximal exercise test (12 samples per subject). Metabolomic profiling of the samples was carried out using hydrophilic interaction chromatography (HILIC) coupled to an Orbitrap Exactive mass spectrometer. Data were extracted, database searched and then subjected to principle components (PCA) and orthogonal partial least squares (OPLSDA) modelling...
2016: Metabolites
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