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https://www.readbyqxmd.com/read/28056429/weight-change-after-initiation-of-oral-hypoglycemic-monotherapy-for-diabetes-predicts-5-year-mortality-an-observational-study
#1
Beverly M Kocarnik, Kathryn P Moore, Nicholas L Smith, Edward J Boyko
PURPOSE: To investigate whether weight change in the first year after initiating an oral hypoglycemic agent (OHA) for type 2 diabetes treatment is associated with mortality in a national cohort. PROCEDURES: We prospectively followed Veterans Health Administration patients with type 2 diabetes initiating treatment with an OHA and not receiving any other diabetes pharmacotherapy for at least one year. Information on OHAs, weight, co-morbidities, other medications, demographics, and laboratory measurements was obtained from electronic medical records...
December 5, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28032669/effects-of-chlorination-on-the-tautomeric-equilibrium-of-2-hydroxypyridine-experiment-and-theory
#2
Camilla Calabrese, Assimo Maris, Iciar Uriarte, Emilio J Cocinero, Sonia Melandri
The effects of halogenation on the tautomeric and conformational equilibria of the model system 2-hydroxypyridine/2-pyridone have been investigated through chlorine substitution at positions 3, 4, 5, and 6. In the gas phase, the lactim syn-periplanar tautomer (OHs ) was the predominant species for all compounds over the lactam form (C=O) and the less abundant anti-periplanar lactim (OHa ). However, the population of the three species was shown to be dependent on the position of the chlorine substitution. Chlorination in position 5 or 6 strongly stabilizes the OHs tautomer, whereas the C=O form has a significant population when the ring is chlorinated in positions 3 or 4...
December 29, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28024571/ocular-biocompatibility-of-gelatin-microcarriers-functionalized-with-oxidized-hyaluronic-acid
#3
Jui-Yang Lai, David Hui-Kang Ma
Given that the presence of aldehyde groups on the oxidized sugar residues may pose toxicity concerns, it is necessary to examine the safety of gelatin microcarriers (GMC) functionalized with oxidized hyaluronic acid (oHA) for potential ophthalmic applications. In this study, the ocular biocompatibility of biopolymer microcarriers was investigated in vitro using primary rabbit corneal cell cultures and in vivo using the anterior chamber of the rabbit eye model. Our results showed that different types of corneal cells including epithelial, stromal, and endothelial cells remain viable and actively proliferate following 2 and 4days of exposure to test materials...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27987832/dual-ph-redox-responsive-and-cd44-receptor-targeting-hybrid-nano-chrysalis-based-on-new-oligosaccharides-of-hyaluronan-conjugates
#4
Daquan Chen, Xue Dong, Mengjiao Qi, Xiaoyan Song, Jingfang Sun
A smart hybrid microenvironment-mediated dual pH/redox-responsive polymeric nanoparticles combined with inorganic calcium phosphate (CaP) was fabricated, which we term as armored nano-chrysalis inspired by butterfly pupa. The nano-chrysalis has an inner core composed of specially designed oligosaccharides of hyaluronan (oHA) targeting CD44 receptor. The inner core has two functions, i.e., the dual pH/redox responsive polymeric conjugate and the fluorescent curcumin-prodrug function. The prepared nano-chrysalis possessed a smaller size (102...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27984840/glycemic-control-and-pregnancy-outcomes-in-women-with-type-2-diabetes-treated-with-oral-hypoglycemic-agents
#5
Maisa N Feghali, Steve N Caritis, Janet M Catov, Christina M Scifres
Objective There is limited data regarding the use of oral hypoglycemic agents (OHAs) in pregnant women with type 2 diabetes mellitus (T2DM). Study Design This was a retrospective cohort study of women with T2DM who were treated with OHA or insulin from the first trimester onward. Bivariate and multivariate logistic regression analyses were used to compare pregnancy outcomes in women treated with OHA to those treated with insulin. Results One-third (67/198) of women were treated with OHA. Women treated with OHA had a shorter disease duration (4...
December 16, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27900971/chronic-kidney-disease-stages-among-diabetes-patients-in-the-cape-coast-metropolis
#6
Richard K D Ephraim, Eric Arthur, W K B A Owiredu, Prince Adoba, Hope Agbodzakey, Ben A Eghan
Diabetes patients worldwide are at a high risk of chronic kidney disease (CKD) which affects their quality of life and increases the risk of early death. This study used the new kidney disease improving global outcomes (KDIGO) guidelines to establish the prevalence and also identify the factors associated with CKD among diabetes patients in the Cape Coast Metropolis. Two hundred (200) diabetes patients were randomly recruited from the diabetic clinic of the Cape Coast Teaching Hospital from January to April 2014...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27867947/association-of-insulin-treatment-versus-oral-hypoglycaemic-agents-with-diabetic-retinopathy-and-its-severity-in-type-2-diabetes-patients-in-cameroon-sub-saharan-africa
#7
Ahmadou M Jingi, Jean Jacques N Noubiap, Mickael Essouma, Jean Joel R Bigna, Jobert Richie N Nansseu, Augustin Ellong, Côme Ebana Mvogo
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease associated with multiple macro and microvascular complications, diabetic retinopathy (DR) being the commonest one. Recent literature has reported an increased risk of DR with insulin use. METHODS: We carried out a cross-sectional study at the Ophthalmology Department of the Douala General Hospital (DGH) during a 2-year period to explore the association between insulin treatment and both DR and its severity as compared with oral hypoglycemic agents (OHAs) in Cameroonian T2DM patients aged ≥35 years, and who were all screened for DR through eye examination including exhaustive retinal evaluation...
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27820794/epidemiological-differences-between-localised-and-non-localised-low-back-pain
#8
David Coggon, Georgia Ntani, Karen Walker-Bone, Keith T Palmer, Vanda E Felli, Raul Harari, Lope H Barrero, Sarah A Felknor, David Gimeno, Anna Cattrell, Sergio Vargas-Prada, Matteo Bonzini, Eleni Solidaki, Eda Merisalu, Rima R Habib, Farideh Sadeghian, M Masood Kadir, Sudath Sp Warnakulasuriya, Ko Matsudaira, Busisiwe Nyantumbu, Malcolm R Sim, Helen Harcombe, Ken Cox, Leila M M Sarquis, Maria H Marziale, Florencia Harari, Rocio Freire, Natalia Harari, Magda V Monroy, Leonardo A Quintana, Marianela Rojas, E Clare Harris, Consol Serra, J Miguel Martinez, George Delclos, Fernando G Benavides, Michele Carugno, Marco M Ferrario, Angela C Pesatori, Leda Chatzi, Panos Bitsios, Manolis Kogevinas, Kristel Oha, Tiina Freimann, Ali Sadeghian, Roshini J Peiris-John, Nalini Sathiakumar, A Rajitha Wickremasinghe, Noriko Yoshimura, Helen L Kelsall, Victor C W Hoe, Donna M Urquhart, Sarah Derrett, David McBride, Peter Herbison, Andrew Gray, Eduardo J Salazar Vega
STUDY DESIGN: Cross-sectional survey with longitudinal follow-up OBJECTIVES.: To test the hypothesis that pain which is localised to the low back differs epidemiologically from that which occurs simultaneously or close in time to pain at other anatomical sites SUMMARY OF BACKGROUND DATA.: Low back pain (LBP) often occurs in combination with other regional pain, with which it shares similar psychological and psychosocial risk factors. However, few previous epidemiological studies of LBP have distinguished pain that is confined to the low back from that which occurs as part of a wider distribution of pain...
November 4, 2016: Spine
https://www.readbyqxmd.com/read/27796465/use-of-pharmacy-dispensing-data-to-measure-adherence-and-identify-nonadherence-with-oral-hypoglycemic-agents
#9
Fong Sodihardjo-Yuen, Liset van Dijk, Michel Wensing, Peter A G M De Smet, Martina Teichert
PURPOSE: A framework for calculation of adherence for oral hypoglycemic agents (OHAs) based on data from health-insurance claims is available. Pharmacy dispensing data aid identification of nonadherent patients in pharmacy practices. However, use of these data for calculation of OHA adherence requires additional methodological categories. We examined the impact of different methodological choices on estimation of OHA adherence using pharmacy dispensing data. METHODS: Four methodological categories were added to the framework available to be used for adherence calculation with pharmacy dispensing data...
October 28, 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27783547/the-impact-of-patient-centered-medical-homes-on-quality-of-care-and-medication-adherence-in-patients-with-diabetes-mellitus
#10
JaeJin An
BACKGROUND: Current evidence suggests that patient-centered medical homes (PCMHs) potentially increase overall quality of disease management, including preventive care. However, there are mixed findings regarding quality of diabetes care, and little evidence exists with respect to the effect of PCMHs on medication adherence in patients with diabetes. OBJECTIVE: To investigate associations between PCMHs and process measures of diabetes care, as well as adherence to oral hypoglycemic agents (OHAs) in patients with diabetes in a nationally representative U...
November 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27762511/a-study-of-effects-of-pioglitazone-and-rosiglitazone-on-various-parameters-in-patients-of-type-2-diabetes-mellitus-with-special-reference-to-lipid-profile
#11
S K Sharma, S H Verma
OBJECTIVES: To study the complete fasting lipid profile and other parameters (weight, body mass index, HbA1c, fasting blood sugar and postprandial blood sugar)in Type 2 diabetes mellitus patients on OHA/insulin, to study the effect of addition of pioglitazone on lipid profile and other parameters in Type 2 diabetes mellitus patients on OHA/insulin, to study the effect of addition of rosiglitazone on lipid profile and other parameters in Type 2 diabetes mellitus patients on OHA/insulin and to compare the effect of pioglitazone and rosiglitazone on lipid profile and other parameters in Type 2 diabetes mellitus patients on OHA/insulin...
September 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27727671/comparative-study-of-nph-insulin-with-glargine-in-patients-of-type-2-diabetes-mellitus-poorly-controlled-with-ohas
#12
B S Bal, Ashok Duggal, Mandeep Kaur, Umar Farooq, Harman Preet Singh
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27712034/delay-of-insulin-initiation-in-patients-with-type-2-diabetes-mellitus-inadequately-controlled-with-oral-hypoglycemic-agents-analysis-of-patients-and-physicians-related-factors-a-prospective-observational-dipp-factor-study-in-korea
#13
Sin Gon Kim, Nam Hoon Kim, Bon Jeong Ku, Ho Sang Shon, Doo Man Kim, Tae Sun Park, Yong-Seong Kim, In Joo Kim, Dong Seop Choi
AIMS/INTRODUCTION: To assess the time to initiation of insulin therapy and concurrently investigate both patient- and physician-related factors associated with delaying insulin therapy in Korean patients with type 2 diabetes (T2D) uncontrolled on oral hypoglycemic agents (OHAs). MATERIALS AND METHODS: This prospective, observational disease registry study was conducted across 69 centers in Korea. T2D patients who had received two or more OHAs within the last 5 years, had a glycated hemoglobin (HbA1c) ≥8% in the last 6 months, and had not received insulin were included...
October 6, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27599981/impact-of-the-use-of-anti-diabetic-drugs-on-survival-of-diabetic-dialysis-patients-a-5-year-retrospective-cohort-study-in-taiwan
#14
Po-Jen Hsiao, Kun-Lin Wu, Szu-Han Chiu, Jenq-Shyong Chan, Yuh-Feng Lin, Chung-Ze Wu, Chia-Chao Wu, SenYeong Kao, Te-Chao Fang, Shih-Hua Lin, Jin-Shuen Chen
BACKGROUND: Type 2 diabetes mellitus (DM) and associated complications are common in patients with chronic kidney disease (CKD) and can increase morbidity and mortality. A longitudinal 5-year observational study was conducted to investigate whether the use of anti-diabetic medications or not affected survival rates of diabetic dialysis patients. METHODS: Using a data sample of a million patients from Taiwan's National Health Insurance Database, a retrospective cohort study surveyed patients with type 2 DM who began dialysis between 2002 and 2007...
September 6, 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/27593867/characteristics-predictive-for-a-successful-switch-from-insulin-analogue-therapy-to-oral-hypoglycemic-agents-in-patients-with-type-2-diabetes
#15
Gyuri Kim, Yong Ho Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Byung Wan Lee
PURPOSE: The objective of this study was to investigate clinical and laboratory parameters that could predict which patients could maintain adequate glycemic control after switching from initial insulin therapy to oral hypoglycemic agents (OHAs) among patients with type 2 diabetes (T2D). MATERIALS AND METHODS: We recruited 275 patients with T2D who had been registered in 3 cohorts of initiated insulin therapy and followed up for 33 months. The participants were divided into 2 groups according to whether they switched from insulin to OHAs (Group I) or not (Group II), and Group I was further classified into 2 sub-groups: maintenance on OHAs (Group IA) or resumption of insulin (Group IB)...
November 2016: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27578618/controversy-of-oral-hypoglycemic-agents-in-type-2-diabetes-mellitus-novel-move-towards-combination-therapies
#16
Abhijit A Ghadge, Aniket A Kuvalekar
AIM: As diabetes mellitus is multi-factorial disease, use of several oral hypoglycemic agents (OHAs) is the main stay of pharmacological treatment. The treatment has become more challenging and controversial as OHAs are heterogeneous in their mode of action that causes unwanted side effects. Complementary approaches such as use of medicinal plants and dietary polyunsaturated fatty acids (PUFA) with hypoglycemic and hypolipidemic activities are therefore imperative. A vast literature has independently documented the effects of OHAs, medicinal plants and PUFA for management of diabetes...
August 22, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27577730/does-spinopelvic-alignment-affect-the-union-status-in-thoracolumbar-osteoporotic-vertebral-compression-fracture
#17
Akira Iwata, Masahiro Kanayama, Fumihiro Oha, Tomoyuki Hashimoto, Norimasa Iwasaki
PURPOSE: In the healing of osteoporotic vertebral fracture, global spinal mal-alignment might increase the load sharing at the fracture site and deteriorate the fracture healing. This study aimed to evaluate the effect of spinopelvic alignment on the union status of thoracolumbar osteoporosis-related vertebral compression fracture (OVCF). METHODS: Consecutive 48 patients with a single-level thoracolumbar fresh OVCF were treated non-operatively. Union was judged by three independent observers at 6 months, and patients were divided into union group and non-union group...
January 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/27549920/prescription-of-oral-hypoglycemic-agents-in-patients-with-type-2-diabetes-mellitus-a-retrospective-cohort-study-using-a-japanese-hospital-database
#18
Makito Tanabe, Ryoko Motonaga, Yuichi Terawaki, Takashi Nomiyama, Toshihiko Yanase
INTRODUCTION: In treatment algorithms of type-2 diabetes mellitus (T2DM) in Western countries, biguanides are recommended as first-line agents. In Japan, various oral hypoglycemic agents (OHAs) are available, but prescription patterns are unclear. MATERIALS AND METHODS: Data of 7,108 and 2,655 T2DM patients in study-1 and -2, respectively, were extracted from the MDV database (2008-2013). Cardiovascular disease (CVD) history was not considered in study-1, but was in study-2...
August 23, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27506310/treatment-discontinuation-of-oral-hypoglycemic-agents-and-healthcare-utilization-among-patients-with-diabetes
#19
Kristi Reynolds, JaeJin An, Jun Wu, Teresa N Harrison, Rong Wei, Bruce Stuart, John P Martin, Catherine S Wlodarczyk, Swapnil N Rajpathak
AIMS: To investigate the discontinuation of oral antihyperglycemic agents (OHA), and examine factors associated with OHA discontinuation, and the effect of OHA discontinuation on glycemic control and healthcare utilization among diabetes patients prescribed dual OHA therapy. METHODS: We identified 23,612 adult patients aged >18years with a diagnosis of type 2 diabetes who initiated dual OHA therapy between 1/1/2005 and 6/30/2010. The date of initiation of the second OHA was defined as the index date...
November 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27453871/an-unusual-case-of-adolescent-type-2-diabetes-mellitus-prader-willi-syndrome
#20
Riyas Basheer, Muhammed Jasim Abdul Jalal, Ramesh Gomez
Prader-Willi syndrome (PWS) is a complex genetic disorder, characterized by neonatal hypotonia, developmental delay, short stature, childhood obesity, hypogonadism, and characteristic facial features. Here we report a 21-year-old male who presented with uncontrolled glycemic status. He was diagnosed to have diabetes mellitus at the age of 15 with osmotic symptoms - polyuria, polydipsia, and polyphagia. In the early period, after diagnosis, his blood sugars were reasonably controlled with oral hypoglycemic agents...
January 2016: Journal of Family Medicine and Primary Care
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