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https://www.readbyqxmd.com/read/28103649/amlodipine-an-l-type-calcium-channel-blocker-protects-against-chlorpromazine-induced-neurobehavioural-deficits-in-mice
#1
Oluwafemi E Kale, Olufunsho Awodele, Temitope O Ogundare, Martins Ekor
The present study investigated the modulatory and chemopreventive benefit of amlodipine (AML), a dihydropyridine calcium channel antagonist, against neurobehavioural abnormalities (NAs) associated with chlorpromazine (CPZ) toxicity in mice. Adult mice were divided into five groups of 6 animals/group. Group 1 (control) was administered saline (10 ml/kg i.p.). Group 2 received CPZ (2 mg/kg i.p.). Groups 3 and 4 received bromocriptine (BMC, 2.5 mg/kg s.c.) and AML (1 mg/kg s.c.) respectively while group 5 received their combination...
January 19, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28103638/music-interventions-for-acquired-brain-injury
#2
REVIEW
Wendy L Magee, Imogen Clark, Jeanette Tamplin, Joke Bradt
BACKGROUND: Acquired brain injury (ABI) can result in impairments in motor function, language, cognition, and sensory processing, and in emotional disturbances, which can severely reduce a survivor's quality of life. Music interventions have been used in rehabilitation to stimulate brain functions involved in movement, cognition, speech, emotions, and sensory perceptions. An update of the systematic review published in 2010 was needed to gauge the efficacy of music interventions in rehabilitation for people with ABI...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28103601/superiority-in-quality-of-life-improvement-of-biologics-over-conventional-systemic-drugs-in-a-swiss-real-life-psoriasis-registry
#3
Pierre Jungo, Julia-Tatjana Maul, Vahid Djamei, Stefanie von Felten, Antonios G A Kolios, Justine Czernielewsk, Nikhil Yawalkar, Olivia Odermatt, Emmanuel Laffitte, Mark Anliker, Markus Streit, Matthias Augustin, Curdin Conrad, Jürg Hafner, Wolf-Henning Boehncke, Michel Gilliet, Peter Itin, Lars E French, Alexander A Navarini, Peter Häusermann
BACKGROUND: Randomized controlled trials have shown the efficacy of systemic treatments in moderate-to-severe psoriasis. Clinical outcomes in psoriasis patients under real-world conditions are less well understood. OBJECTIVE: This study compared Psoriasis Area and Severity Index (PASI) and Dermatological Life Quality Index (DLQI) improvement in all psoriasis patients registered in the Swiss Dermatology Network for Targeted Therapies. We asked whether outcomes differed between 4 treatment strategies, namely biologic monotherapy versus conventional systemic monotherapy, versus combined biologic and conventional systemic drugs, and versus therapy adaptation (switching from one type to another)...
January 20, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28103592/influences-of-various-peptide-linkers-on-the-thermotoga-maritima-msb8-nitrilase-displayed-on-the-spore-surface-of-bacillus-subtilis
#4
Huayou Chen, Zhi Chen, Bangguo Wu, Jawad Ullah, Tianxi Zhang, Jinru Jia, Hongcheng Wang, Tianwei Tan
In the present study, fusion genes composed of Thermotoga maritima MSB8 nitrilase and Bacillus subtilis 168 outer coat protein CotG were constructed with various peptide linkers and displayed on B. subtilis DB 403 spores. The successful display of CotG-nit fusion proteins on the spore surface of B. subtilis was verified by Western blot analysis and activity measurement. It was demonstrated that the fusion with linker GGGGSEAAAKGGGGS presented the highest thermal and pH stability, which is 2.67- and 1.9-fold of the fusion without linker...
January 20, 2017: Journal of Molecular Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28103528/topical-vaccination-with-super-stable-ready-to-use-nanovesicles
#5
Ayelen Tatiana Caimi, Federico Parra, Marcelo Alexander de Farias, Rodrigo Villares Portugal, Ana Paula Perez, Eder Lilia Romero, Maria Jose Morilla
Ultradeformable archaeosomes (UDA) are nanovesicles made of total polar archaeolipids (TPA) from the archaea Halorubrum tebenquichense, soybean phosphatidylcholine and sodium cholate (3:3:1w/w). Fresh dispersions of UDA including different type of antigens are acknowledged as efficient topical vaccination agents. UDA dispersions however, if manufactured for pharmaceutical use, have to maintain colloidal stability upon liposomicidal processes such as sterilization and lyophilization (SLRUDA), needed to extend shelf life during storage...
December 26, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28103519/do-cognitive-schema-mediate-the-association-between-childhood-trauma-and-being-at-ultra-high-risk-for-psychosis
#6
E Appiah-Kusi, H L Fisher, N Petros, R Wilson, V Mondelli, P A Garety, P Mcguire, S Bhattacharyya
Exposure to childhood trauma has been associated with psychotic symptoms, being at ultra-high risk for psychosis (UHR), and psychotic disorders such as schizophrenia. Negative self-beliefs have been shown to partially mediate the relationship between childhood trauma and paranoia and have been shown to be characteristic of patients with psychosis. However, whether the association between childhood trauma and being at high risk of developing psychosis (e.g., UHR) and paranoia symptoms is mediated by altered cognitive schema is unknown and warrants investigation to inform preventive interventions...
January 6, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28103492/a-novel-type-of-gene-interaction-in-d-melanogaster
#7
B F Chadov, E V Chadova, N B Fedorova
The genes interact according to classical mechanisms, namely, complementation, modification, polymery, and epistasis, in the cells and organisms carrying these genes. Here we describe a novel type of gene interaction when the interacting genes reside in parents, whereas the interaction event takes place in their progenies lacking these genes. The conditional mutations in the D. melanogaster male X chromosome caused the "prohibition on producing daughters" in its offspring. The chromosomal rearrangements in chromosomes 2 and 3 of its female partner removed the prohibition...
January 11, 2017: Mutation Research
https://www.readbyqxmd.com/read/28103491/chemically-activated-carbon-from-lignocellulosic-wastes-for-heavy-metal-wastewater-remediation-effect-of-activation-conditions
#8
Arunima Nayak, Brij Bhushan, Vartika Gupta, P Sharma
Chemical activation is known to induce specific surface features of porosity and functionality which play a definite role in enhancing the adsorptive potential of the developed activated carbons. Different conditions of temperature, time, reagent type and impregnation ratio were applied on sawdust precursor and their effect on the physical, surface chemical features and finally on the adsorption potential of the developed activated carbons were analysed. Under activation conditions of 600°C, 1hr, 1:0.5 ratio, ZnCl2 impregnated carbon (CASD_ZnCl2) resulted in microporosity while KOH impregnation (CASD_KOH) yielded a carbon having a wider pore size distribution...
January 10, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28103456/health-inequalities-in-diabetes-mellitus-and-hypertension-a-parish-level-study-in-the-northern-region-of-portugal
#9
Teresa Leao, Julian Perelman, Manuela Felício, Vasco Machado, Graça Lima
INTRODUCTION: Diabetes and hypertension are highly prevalent conditions in Portugal. Little is known about the geographical and social patterning of these diseases, which precludes the design of targeted health policies. This study aimed to measure the geographical and socioeconomic distribution of type 2 diabetes and hypertension prevalence in the population resident in the Northern region of Portugal, for the year 2013. MATERIAL AND METHODS: An ecological correlation study analyzed the 2,028 parishes of the region...
October 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28103412/what-determines-posttraumatic-stress-and-growth-following-various-traumatic-events-a-study-in-a-turkish-community-sample
#10
Ervin Gul, A Nuray Karanci
This study aimed to examine the roles of personality traits, traumatic event types, coping, rumination, and social support in explaining posttraumatic stress symptoms (PTS) and posttraumatic growth (PTG) in a representative community sample of 498 Turkish adults. The results of 2 multiple regression analyses showed that PTS was associated with neuroticism, experiencing events involving intentional/assaultive violence, intrusive and deliberate rumination, and fatalistic coping. In contrast, PTG was related to conscientiousness, openness to experience, injury/shocking and sudden-death type of events, deliberate rumination, problem-solving coping, and perceived social support...
January 19, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28103405/altered-walking-strategy-and-increased-unsteadiness-in-participants-with-impaired-glucose-tolerance-and-type-2-diabetes-relates-to-small-fibre-neuropathy-but-not-vitamin-d-deficiency
#11
M M Almurdhi, S J Brown, F L Bowling, A J M Boulton, Maria Jeziorska, Rayaz A Malik, Neil D Reeves
AIMS: To investigate alterations in walking strategy and dynamic sway (unsteadiness) in people with impaired glucose tolerance and people with Type 2 diabetes in relation to severity of neuropathy and vitamin D levels. METHODS: A total of 20 people with Type 2 diabetes, 20 people with impaired glucose tolerance and 20 people without either Type 2 diabetes or impaired glucose tolerance (control group) underwent gait analysis using a motion analysis system and force platforms, and detailed assessment of neuropathy and serum 25 hydroxy-vitamin D levels...
January 19, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28103312/increased-cardiovascular-events-and-subclinical-atherosclerosis-in-rheumatoid-arthritis-patients-1-year-prospective-single-centre-study
#12
Piero Ruscitti, Paola Cipriani, Francesco Masedu, Silvio Romano, Onorina Berardicurti, Vasiliki Liakouli, Francesco Carubbi, Paola Di Benedetto, Saverio Alvaro, Maria Penco, Marco Valenti, Roberto Giacomelli
OBJECTIVES: Several studies showed the close relationship between Rheumatoid Arthritis (RA) and cerebro-cardiovascular events (CVEs) and subclinical atherosclerosis. In this study, we investigated the occurrence of CVEs and subclinical atherosclerosis during the course of RA and we evaluated the possible role of both traditional cardiovascular (CV) and disease related risk factors to predict the occurrence of new CVEs and the onset of subclinical atherosclerosis. METHODS: We designed a single centre, bias-adjusted, prospective, observational study to investigate, in a homogeneous subset of RA patients, the occurrence of new onset of CVEs and subclinical atherosclerosis...
2017: PloS One
https://www.readbyqxmd.com/read/28103310/epidemiological-and-molecular-characterization-of-a-mexican-population-isolate-with-high-prevalence-of-limb-girdle-muscular-dystrophy-type-2a-due-to-a-novel-calpain-3-mutation
#13
Carlos A Pantoja-Melendez, Antonio Miranda-Duarte, Bladimir Roque-Ramirez, Juan C Zenteno
Limb-Girdle Muscular Dystrophy type 2 (LGMD2) is a group of autosomally recessive inherited disorders defined by weakness and wasting of the shoulder and pelvic girdle muscles. In the past, several population isolates with high incidence of LGMD2 arising from founder mutation effects have been identified. The aim of this work is to describe the results of clinical, epidemiologic, and molecular studies performed in a Mexican village segregating numerous cases of LGMD2. A population census was conducted in the village to identify all LGMD affected patients...
2017: PloS One
https://www.readbyqxmd.com/read/28103298/perinatal-choline-supplementation-reduces-amyloidosis-and-increases-choline-acetyltransferase-expression-in-the-hippocampus-of-the-appsweps1de9-alzheimer-s-disease-model-mice
#14
Tiffany J Mellott, Olivia M Huleatt, Bethany N Shade, Sarah M Pender, Yi B Liu, Barbara E Slack, Jan K Blusztajn
Prevention of Alzheimer's disease (AD) is a major goal of biomedical sciences. In previous studies we showed that high intake of the essential nutrient, choline, during gestation prevented age-related memory decline in a rat model. In this study we investigated the effects of a similar treatment on AD-related phenotypes in a mouse model of AD. We crossed wild type (WT) female mice with hemizygous APPswe/PS1dE9 (APP.PS1) AD model male mice and maintained the pregnant and lactating dams on a control AIN76A diet containing 1...
2017: PloS One
https://www.readbyqxmd.com/read/28103290/involvement-of-ddah-adma-nos-cgmp-and-cox-2-ptgis-camp-pathways-in-human-tissue-kallikrein-1-protecting-erectile-function-in-aged-rats
#15
Kai Cui, Yang Luan, Zhe Tang, Ke Rao, Tao Wang, Zhong Chen, Shaogang Wang, Jihong Liu, Daowen Wang
Our previous studies had reported that Human Tissue Kallikrein 1 (hKLK1) preserved erectile function in aged transgenic rats, while the detailed mechanism of hKLK1 protecting erectile function in aged rats through activation of cGMP and cAMP was not mentioned. To explore the latent mechanism, male wild-type Sprague-Dawley rats (WTR) and transgenic rats harboring the hKLK1 gene (TGR) were fed to 4 and 18 months old and divided into four groups: young WTR (yWTR) as the control, aged WTR (aWTR), aged TGR (aTGR) and aged TGRs with HOE140 (aTGRH)...
2017: PloS One
https://www.readbyqxmd.com/read/28103279/aristaless-related-homeobox-arx-interacts-with-%C3%AE-catenin-bcl9-and-p300-to-regulate-canonical-wnt-signaling
#16
Il-Taeg Cho, Youngshin Lim, Jeffrey A Golden, Ginam Cho
Mutations in the Aristaless Related Homeobox (ARX) gene are associated with a spectrum of structural (lissencephaly) and functional (epilepsy and intellectual disabilities) neurodevelopmental disorders. How mutations in this single transcription factor can result in such a broad range of phenotypes remains poorly understood. We hypothesized that ARX functions through distinct interactions with specific transcription factors/cofactors to regulate unique target genes in different cell types. To identify ARX interacting proteins, we performed an unbiased proteomics screen and identified several components of the Wnt/β-catenin signaling pathway, including β-catenin (CTNNB1), B-cell CLL/lymphoma 9 (BCL9) and leucine rich repeat flightless interacting protein 2 (LRRFIP2), in cortical progenitor cells...
2017: PloS One
https://www.readbyqxmd.com/read/28103276/comparison-of-the-effect-of-two-kinds-of-iranian-honey-and-diphenhydramine-on-nocturnal-cough-and-the-sleep-quality-in-coughing-children-and-their-parents
#17
Parviz Ayazi, Abolfazl Mahyar, Mahdieh Yousef-Zanjani, Abbas Allami, Neda Esmailzadehha, Taraneh Beyhaghi
Coughing in a child induced by upper respiratory tract infections (URTIs) can be a problem, both for the child and its parents. Current studies show a lack of proven efficacy for over-the counter (OTC) medications, but promising data support the use of honey for children. The aim of this study was to compare the effects of two kinds of Iranian honey with diphenhydramine (DPH) on nocturnal pediatric coughs and the sleep quality of children and their parents. This was a clinical trial (registered in IRCT; No...
2017: PloS One
https://www.readbyqxmd.com/read/28103272/prevalence-and-determinants-of-oral-human-papillomavirus-infection-in-500-young-adults-from-italy
#18
Valentina Lupato, Dana Holzinger, Daniela Höfler, Anna Menegaldo, Paolo Giorgi Rossi, Annarosa Del Mistro, Maria Cristina Da Mosto, Michael Pawlita, Paolo Boscolo-Rizzo
Although the prevalence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) is increasing in developed countries and becoming a relevant health issue, the natural history of oral HPV infection is still unclear. Estimating the infection's prevalence in specific populations and identifying risk factors can widen our understanding of its natural history and help to delineate appropriate prevention strategies. This study sought to (i) determine oral HPV prevalence and genotype distribution in a large series of young Italian adults, (ii) validate an oral rinse sampling/storage protocol, and (iii) pinpoint factors associated with oral HPV infection...
2017: PloS One
https://www.readbyqxmd.com/read/28103262/serotype-distribution-and-antimicrobial-sensitivity-profile-of-streptococcus-pneumoniae-carried-in-healthy-toddlers-before-pcv13-introduction-in-niamey-niger
#19
Sani Ousmane, Bouli A Diallo, Rasmata Ouedraogo, Abdel-Kader A Sanda, Amadou M Soussou, Jean-Marc Collard
BACKGROUND: To mitigate the burden of pneumococcal infections in Niger, a 13-valent pneumococcal vaccine, PCV13, was introduced for routine child vaccination in July 2014. In order to provide pre-vaccine baseline data and allow appreciation of changes on carriage due to vaccination, we analyzed retrospectively pneumococcal isolates obtained from healthy, 0 to 2 year old children prior to the vaccine introduction. METHODS: From June 5, 2007, to May 26, 2008, 1200 nasopharyngeal swabs were collected from healthy 0 to 2 year old children and analyzed by standard microbiological methods...
2017: PloS One
https://www.readbyqxmd.com/read/28103246/joint-optimization-of-distribution-network-design-and-two-echelon-inventory-control-with-stochastic-demand-and-co2-emission-tax-charges
#20
Shuangyan Li, Xialian Li, Dezhi Zhang, Lingyun Zhou
This study develops an optimization model to integrate facility location and inventory control for a three-level distribution network consisting of a supplier, multiple distribution centers (DCs), and multiple retailers. The integrated model addressed in this study simultaneously determines three types of decisions: (1) facility location (optimal number, location, and size of DCs); (2) allocation (assignment of suppliers to located DCs and retailers to located DCs, and corresponding optimal transport mode choices); and (3) inventory control decisions on order quantities, reorder points, and amount of safety stock at each retailer and opened DC...
2017: PloS One
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