Madelon M E de Jong, Cathelijne Fokkema, Natalie Papazian, Ágnes Czeti, Marjolein K Appelman, Michael Vermeulen, Teddie van Heusden, Remco M Hoogenboezem, Gregory van Beek, Sabrin Tahri, Mathijs A Sanders, Pieter C van de Woestijne, Francesca Gay, Philippe Moreau, Maike Büttner-Herold, Heiko Bruns, Mark van Duin, Annemiek Broijl, Pieter Sonneveld, Tom Cupedo
Human bone marrow permanently harbors high numbers of neutrophils, and a tumor-supportive bias of these cells could significantly impact bone marrow-confined malignancies. In individuals with multiple myeloma, the bone marrow is characterized by inflammatory stromal cells with the potential to influence neutrophils. We investigated myeloma-associated alterations in human marrow neutrophils and the impact of stromal inflammation on neutrophil function. Mature neutrophils in myeloma marrow are activated and tumor supportive and transcribe increased levels of IL1B and myeloma cell survival factor TNFSF13B (BAFF)...
April 10, 2024: Nature Immunology