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https://www.readbyqxmd.com/read/28944609/hypertension-management-research-priorities-from-patients-caregivers-and-healthcare-providers-a-report-from-the-hypertension-canada-priority-setting-partnership-group
#1
Nadia Khan, Simon L Bacon, Samia Khan, Sara Perlmutter, Carline Gerlinsky, Mark Dermer, Lonni Johnson, Finderson Alves, Donna McLean, Andreas Laupacis, Mandy Pui, Angelique Berg, Felicia Flowitt
Patient- and stakeholder-oriented research is vital to improving the relevance of research. The authors aimed to identify the 10 most important research priorities of patients, caregivers, and healthcare providers (family physicians, nurses, nurse practitioners, pharmacists, and dietitians) for hypertension management. Using the James Lind Alliance approach, a national web-based survey asked patients, caregivers, and care providers to submit their unanswered questions on hypertension management. Questions already answered from randomized controlled trial evidence were removed...
September 25, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28944234/the-nextgen-study-patient-motivation-for-participation-in-genome-sequencing-for-carrier-status
#2
Tia L Kauffman, Stephanie A Irving, Michael C Leo, Marian J Gilmore, Patricia Himes, Carmit K McMullen, Elissa Morris, Jennifer Schneider, Benjamin S Wilfond, Katrina A B Goddard
BACKGROUND: While translational genomic sequencing research is increasing, few studies have been limited to healthy individuals; most have focused on patients with a disease or a strong family history of a disorder. The limited studies that have included healthy individuals have focused on the disclosure of medically actionable secondary results, rather than carrier status, to assess reproductive risks. To address this important gap, we conducted the NextGen study, which focuses on carrier status and medically actionable secondary findings in a population of women planning a pregnancy...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28943073/the-reliability-and-validity-of-a-venezuelan-version-of-the-bath-ankylosing-spondylitis-functional-index-basfi-and-bath-ankylosing-spondylitis-disease-activity-index-basdai
#3
Mayra Rauseo Vera, Luis Arturo Gutiérrez-González, Irama Maldonado, Soham Al Snih
INTRODUCTION: Spondyloarthropathies (SpA) are disabling diseases with a prevalence of 1.9% in the general population. The indices designed for monitoring the disease should be valid, reliable and cross-culturally adapted for decision-making concerning the appropriate treatment. Changing an adjective or pronoun in a self-administered questionnaire could be the big difference in condensing an idea in a few words and transmitting that concept to all those who share the same language. OBJECTIVES: To develop a Venezuelan version of the original English version of the BASDAI/BASFI and to evaluate its reliability and validity in Venezuelan patients with SpA...
September 21, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28942899/strategies-to-translate-knowledge-related-to-common-musculoskeletal-conditions-into-physiotherapy-practice-a-systematic-review
#4
REVIEW
Marie-Ève Bérubé, Stéphane Poitras, Marc Bastien, Lydie-Anne Laliberté, Anyck Lacharité, Douglas P Gross
BACKGROUND: Many physiotherapists underuse evidence-based practice guidelines or recommendations when treating patients with musculoskeletal disorders, yet synthesis of knowledge translation interventions used within the field of physiotherapy fails to offer clear conclusions to guide the implementation of clinical practice guidelines. OBJECTIVES: To evaluate the effectiveness of various knowledge translation interventions used to implement changes in the practice of current physiotherapists treating common musculoskeletal issues...
May 26, 2017: Physiotherapy
https://www.readbyqxmd.com/read/28942739/the-predictive-value-of-symptoms-for-anxiety-in-hospice-inpatients-with-advanced-cancer
#5
Danielle Zweers, Everlien de Graaf, Alexander de Graeff, Rebecca K Stellato, Petronella O Witteveen, Saskia C C M Teunissen
OBJECTIVE: Insight into symptoms as predictors for anxiety may help to foster early identification of anxiety and to ameliorate anxiety management. The aim of this study was to determine which frequently occurring symptoms are predictors for anxiety in advanced cancer patients recently admitted to a hospice. METHOD: Symptom burden was measured in patients admitted to a hospice who died ≤3 month after admission using the Utrecht Symptom Diary. This is a Dutch-translated and adapted version of the Edmonton Symptom Assessment System to self-assess the 11 most prevalent symptoms and overall well-being on a 0-10 numerical rating scale...
September 25, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28942497/dynamic-n-glycoproteome-analysis-of-maize-seedling-leaves-during-de-etiolation-using-concanavalin-a-lectin-affinity-chromatography-and-a-nano-lc-ms-ms-based-itraq-approach
#6
Tian-Tian Bu, Jie Shen, Qing Chao, Zhuo Shen, Zhen Yan, Hai-Yan Zheng, Bai-Chen Wang
The identification of N -glycosylated proteins with information about changes in the level of N -glycosylation during de-etiolation provides a database that will aid further research on plant N -glycosylation and de-etiolation. N-glycosylation is one of the most prominent and abundant protein post-translational modifications in all eukaryotes and in plants it plays important roles in development, stress tolerance and immune responses. Because light-induced de-etiolation is one of the most dramatic developmental processes known in plants, seedlings undergoing de-etiolation are an excellent model for investigating dynamic proteomic profiles...
September 23, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28942481/high-resolution-vessel-wall-mri-for-the-evaluation-of-intracranial-atherosclerotic-disease
#7
REVIEW
Adam de Havenon, Mahmud Mossa-Basha, Lubdha Shah, Seong-Eun Kim, Min Park, Dennis Parker, J Scott McNally
High-resolution vessel wall MRI (vwMRI) of the intracranial arteries is an emerging diagnostic imaging technique with the goal of evaluating vascular pathology. vwMRI sequences have high spatial resolution and directly image the vessel wall by suppressing blood signal. With vwMRI, it is possible to identify distinct morphologic and enhancement patterns of atherosclerosis that can provide important information about stroke etiology and recurrence risk. We present a review of vwMRI research in relation to intracranial atherosclerosis, with a focus on the relationship between ischemic stroke and atherosclerotic plaque T1 post-contrast enhancement or plaque/vessel wall morphology...
September 23, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28942197/integrated-metabolic-models-for-xenobiotic-induced-mitochondrial-toxicity-in-skeletal-muscle
#8
William Dott, Jayne Wright, Kelvin Cain, Pratibha Mistry, Karl E Herbert
There is a need for robust in vitro models to sensitively capture skeletal muscle adverse toxicities early in the research and development of novel xenobiotics. To this end, an in vitro rat skeletal muscle model (L6) was used to study the translation of transcriptomics data generated from an in vivo rat model. Novel sulfonyl isoxazoline herbicides were associated with skeletal muscle toxicity in an in vivo rat model. Gene expression pathway analysis on skeletal muscle tissues taken from in vivo repeat dose studies identified enriched pathways associated with mitochondrial dysfunction, oxidative stress, energy metabolism, protein regulation and cell cycle...
September 18, 2017: Redox Biology
https://www.readbyqxmd.com/read/28941577/route-of-placebo-administration-robust-placebo-effects-in-laboratory-and-clinical-settings
#9
REVIEW
Tao Liu
Recent advances in laboratory and clinical research have greatly enhanced our understanding of placebo effects. However, little progress has been made in translational research that can well integrate these findings. This article examines pivotal role of placebo administration in subsequent placebo responses, providing a unified framework that accounts for robust placebo effects in both laboratory and clinical settings.
September 20, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28941528/dominant-optic-atrophy-and-leber-s-hereditary-optic-neuropathy-update-on-clinical-features-and-current-therapeutic-approaches
#10
Bo Young Chun, Joseph F Rizzo
Dominant optic atrophy (DOA) and Leber hereditary optic neuropathy (LHON) are the two most common inherited optic neuropathies encountered in clinical practice. This review provides a summary of recent advances in the understanding of the clinical manifestations, current treatments, and ongoing clinical trials of these two optic neuropathies. Substantial progress has been made in the understanding of the clinical, genetic, and pathophysiological basis of DOA and LHON. Pathogenic OPA1 gene mutations in DOA and 3 primary mutations of mitochondrial DNA in LHON-induced mitochondrial dysfunction, which in turn leads to increased reactive oxygen species levels in mitochondria and possibly insufficient ATP production...
May 2017: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/28941317/concise-review-extracellular-vesicles-overcoming-limitations-of-cell-therapies-in-ischemic-stroke
#11
Thorsten R Doeppner, Mathias Bähr, Dirk M Hermann, Bernd Giebel
Despite recent advances in stroke therapy, current therapeutic concepts are still limited. Thus, additional therapeutic strategies are in order. In this sense, the transplantation of stem cells has appeared to be an attractive adjuvant tool to help boost the endogenous regenerative capacities of the brain. Although transplantation of stem cells is known to induce beneficial outcome in (preclinical) stroke research, grafted cells do not replace lost tissue directly. Rather, these transplanted cells like neural progenitor cells or mesenchymal stem cells act in an indirect manner, among which the secretion of extracellular vesicles (EVs) appears to be one key factor...
September 23, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28941162/an-in-vitro-simulation-model-to-assess-the-severity-of-edge-loading-and-wear-due-to-variations-in-component-positioning-in-hip-joint-replacements
#12
O O'Dwyer Lancaster-Jones, S Williams, L M Jennings, J Thompson, G H Isaac, J Fisher, M Al-Hajjar
The aim of this study was to develop a preclinical in vitro method to predict the occurrence and severity of edge loading condition associated with the dynamic separation of the centres of the head and cup (in the absence of impingement) for variations in surgical positioning of the cup. Specifically, this study investigated the effect of both the variations in the medial-lateral translational mismatch between the centres of the femoral head and acetabular cup and the variations in the cup inclination angles on the occurrence and magnitude of the dynamic separation, the severity of edge loading, and the wear rate of ceramic-on-ceramic hip replacement bearings in a multi-station hip joint simulator during a walking gait cycle...
September 23, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28940482/a-method-to-establish-stimulus-control-and-compliance-with-instructions
#13
John G Borgen, F Charles Mace, Brenna M Cavanaugh, Kenneth Shamlian, Keith R Lit, Jillian B Wilson, Stephanie L Trauschke
We evaluated a unique procedure to establish compliance with instructions in four young children diagnosed with autism spectrum disorder (ASD) who had low levels of compliance. Our procedure included methods to establish a novel therapist as a source of positive reinforcement, reliably evoke orienting responses to the therapist, increase the number of exposures to instruction-compliance-reinforcer contingencies, and minimize the number of exposures to instruction-noncompliance-no reinforcer contingencies. We further alternated between instructions with a high probability of compliance (high-p instructions) with instructions that had a prior low probability of compliance (low-p instructions) as soon as low-p instructions lost stimulus control...
September 20, 2017: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/28940050/can-models-of-self-management-support-be-adapted-across-cancer-types-a-comparison-of-unmet-self-management-needs-for-patients-with-breast-or-colorectal-cancer
#14
Elise Mansfield, Lisa Mackenzie, Mariko Carey, Kerry Peek, Jan Shepherd, Tiffany-Jane Evans
PURPOSE: There is an increased focus on supporting patients with cancer to actively participate in their healthcare, an approach commonly termed 'self-management'. Comparing unmet self-management needs across cancer types may reveal opportunities to adapt effective self-management support strategies from one cancer type to another. Given that breast and colorectal cancers are prevalent, and have high survival rates, we compared these patients' recent need for help with self-management...
September 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28939699/health-and-well-being-management-in-the-military-a-systematic-review-of-genetic-studies
#15
REVIEW
Nathan Parnell, K Rye, N Greenberg
BACKGROUND: Genetic research may have therapeutic value for mental and physical disorders and could have an indicative or preventative capacity. Little is known about the extent, form and utility of military-specific genetic research. METHOD: A systematic review was conducted to evaluate existing genetic well-being studies of service personnel. The review specifically aimed to ascertain the current state of knowledge and feasibility of using genetics to aid recruitment and health management within military populations...
September 21, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/28939212/fortilin-a-potential-target-for-the-prevention-and-treatment-of-human-diseases
#16
Decha Pinkaew, Ken Fujise
Fortilin is a highly conserved 172-amino-acid polypeptide found in the cytosol, nucleus, mitochondria, extracellular space, and circulating blood. It is a multifunctional protein that protects cells against apoptosis, promotes cell growth and cell cycle progression, binds calcium (Ca(2+)) and has antipathogen activities. Its role in the pathogenesis of human and animal diseases is also diverse. Fortilin facilitates the development of atherosclerosis, contributes to both systemic and pulmonary arterial hypertension, participates in the development of cancers, and worsens diabetic nephropathy...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28938953/common-elements-in-rare-kidney-diseases-conclusions-from-a-kidney-disease-improving-global-outcomes-kdigo-controversies-conference
#17
Ségolène Aymé, Detlef Bockenhauer, Simon Day, Olivier Devuyst, Lisa M Guay-Woodford, Julie R Ingelfinger, Jon B Klein, Nine V A M Knoers, Ronald D Perrone, Julia Roberts, Franz Schaefer, Vicente E Torres, Michael Cheung, David C Wheeler, Wolfgang C Winkelmayer
Rare kidney diseases encompass at least 150 different conditions, most of which are inherited. Although individual rare kidney diseases raise specific issues, as a group these rare diseases can have overlapping challenges in diagnosis and treatment. These challenges include small numbers of affected patients, unidentified causes of disease, lack of biomarkers for monitoring disease progression, and need for complex care. To address common clinical and patient issues among rare kidney diseases, the KDIGO Controversies Conference entitled, Common Elements in Rare Kidney Diseases, brought together a panel of multidisciplinary clinical providers and patient advocates to address five central issues for rare kidney diseases...
October 2017: Kidney International
https://www.readbyqxmd.com/read/28938901/validation-of-the-vascular-quality-of-life-questionnaire-6-for-clinical-use-in-patients-with-lower-limb-peripheral-arterial-disease
#18
Anne Sofie F Larsen, Anne Therese Reiersen, Morten B Jacobsen, Nils-Einar Kløw, Joakim Nordanstig, Mark Morgan, Jarlis Wesche
BACKGROUND: The VascuQoL-6 (VQ-6) health-related quality of life questionnaire, a short version of the disease-specific VascuQoL-25, was developed for clinical practice and use in vascular registries. The study purpose was to evaluate the validity and reliability of VQ-6. METHODS: VQ-6 was translated to Norwegian with linguistic validation and face value evaluation, and consecutive patients with intermittent claudication (IC) or critical limb ischemia (CLI) were included...
September 22, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28938868/start-a-system-for-flexible-analysis-of-hundreds-of-genomic-signal-tracks-in-few-lines-of-sql-like-queries
#19
Xinjie Zhu, Qiang Zhang, Eric Dun Ho, Ken Hung-On Yu, Chris Liu, Tim H Huang, Alfred Sze-Lok Cheng, Ben Kao, Eric Lo, Kevin Y Yip
BACKGROUND: A genomic signal track is a set of genomic intervals associated with values of various types, such as measurements from high-throughput experiments. Analysis of signal tracks requires complex computational methods, which often make the analysts focus too much on the detailed computational steps rather than on their biological questions. RESULTS: Here we propose Signal Track Query Language (STQL) for simple analysis of signal tracks. It is a Structured Query Language (SQL)-like declarative language, which means one only specifies what computations need to be done but not how these computations are to be carried out...
September 22, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28938796/complex-interactions-of-circadian-rhythms-eating-behaviors-and-the-gastrointestinal-microbiota-and-their-potential-impact-on-health
#20
Jennifer L Kaczmarek, Sharon V Thompson, Hannah D Holscher
Human health is intricately intertwined with the composition and function of the trillions of microorganisms that make up the gastrointestinal (GI) microbiome. The GI microbiome is essentially a microbial organ that provides metabolic, immunologic, and protective functions for the host. Habitual diet, changes in macronutrient composition, and consumption of nondigestible dietary fibers have all been shown to impact the human GI microbiome. Intriguingly, the impact of diet on the microbiome may be related not only to what humans eat but also to the timing of food consumption...
September 1, 2017: Nutrition Reviews
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