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https://www.readbyqxmd.com/read/28222516/intelligent-assistive-technology-for-alzheimer-s-disease-and-other-dementias-a-systematic-review
#1
Marcello Ienca, Jotterand Fabrice, Bernice Elger, Maurizio Caon, Alessandro Scoccia Pappagallo, Reto W Kressig, Tenzin Wangmo
Intelligent assistive technologies (IATs) have the potential of offering innovative solutions to mitigate the global burden of dementia and provide new tools for dementia care. While technological opportunities multiply rapidly, clinical applications are rare as the technological potential of IATs remains inadequately translated into dementia care. In this article, the authors present the results of a systematic review and the resulting comprehensive technology index of IATs with application in dementia care...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222119/revised-hammersmith-scale-for-spinal-muscular-atrophy-a-sma-specific-clinical-outcome-assessment-tool
#2
Danielle Ramsey, Mariacristina Scoto, Anna Mayhew, Marion Main, Elena S Mazzone, Jacqueline Montes, Roberto de Sanctis, Sally Dunaway Young, Rachel Salazar, Allan M Glanzman, Amy Pasternak, Janet Quigley, Elizabeth Mirek, Tina Duong, Richard Gee, Matthew Civitello, Gihan Tennekoon, Marika Pane, Maria Carmela Pera, Kate Bushby, John Day, Basil T Darras, Darryl De Vivo, Richard Finkel, Eugenio Mercuri, Francesco Muntoni
Recent translational research developments in Spinal Muscular Atrophy (SMA), outcome measure design and demands from regulatory authorities require that clinical outcome assessments are 'fit for purpose'. An international collaboration (SMA REACH UK, Italian SMA Network and PNCRN USA) undertook an iterative process to address discontinuity in the recorded performance of the Hammersmith Functional Motor Scale Expanded and developed a revised functional scale using Rasch analysis, traditional psychometric techniques and the application of clinical sensibility via expert panels...
2017: PloS One
https://www.readbyqxmd.com/read/28222111/a-meta-analysis-of-the-abscopal-effect-in-preclinical-models-is-the-biologically-effective-dose-a-relevant-physical-trigger
#3
Raffaella Marconi, Silvia Strolin, Gianluca Bossi, Lidia Strigari
BACKGROUND: Preclinical in vivo studies using small animals are considered crucial in translational cancer research and clinical implementation of novel treatments. This is of paramount relevance in radiobiology, especially for any technological developments permitted to deliver high doses in single or oligo-fractionated regimens, such as stereotactic ablative radiotherapy (SABR). In this context, clinical success in cancer treatment needs to be guaranteed, sparing normal tissue and preventing the potential spread of disease or local recurrence...
2017: PloS One
https://www.readbyqxmd.com/read/28222000/fast-prediction-of-protein-methylation-sites-using-a-sequence-based-feature-selection-technique
#4
Leyi Wei, Pengwei Xing, Gaotao Shi, Zhi-Liang Ji, Quan Zou
Protein methylation, an important post-translational modification, plays crucial roles in many cellular processes. The accurate prediction of protein methylation sites is fundamentally important for revealing the molecular mechanisms undergoing methylation. In recent years, computational prediction based on machine learning algorithms has emerged as a powerful and robust approach for identifying methylation sites, and much progress has been made in predictive performance improvement. However, the predictive performance of existing methods is not satisfactory in terms of overall accuracy...
February 16, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28221990/an-integrated-circuit-for-simultaneous-extracellular-electrophysiology-recording-and-optogenetic-neural-manipulation
#5
Chang Hao Chen, Elizabeth A McCullagh, Sio Hang Pun, Peng Un Mak, Mang I Vai, Pui In Mak, Achim Klug, Tim C Lei
OBJECTIVE: The ability to record and to control action potential firing in neuronal circuits is critical to understand how the brain functions. The objective of this study is to develop a monolithic integrated circuit (IC) to record action potentials and simultaneously control action potential firing using optogenetics. METHODS: A low-noise and high input impedance (or low input capacitance) neural recording amplifier is combined with a high current laser/light-emitting diode (LED) driver in a single IC...
March 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28221214/an-integrative-review-of-psychosocial-concerns-among-young-african-american-breast-cancer-survivors
#6
Timiya S Nolan, Jennifer Frank, Silvia Gisiger-Camata, Karen Meneses
BACKGROUND: African American (AA) women are more likely to be given a diagnosis of breast cancer at an early age, experience morbidity after treatment, and exhibit disparities in survivorship. Although psychosocial well-being is largely studied among breast cancer survivors, data are sparse regarding young AA survivors. OBJECTIVE: This integrative review examined psychosocial concerns in survivorship among young AA survivors using a quality-of-life framework. METHODS: PubMed, CINHAL, EMBASE, PsychINFO, and Scopus were searched for articles exploring psychosocial well-being in young AA survivors...
February 17, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28221064/breaking-ground-for-psychological-science-the-u-s-food-and-drug-administration
#7
Baruch Fischhoff
The U.S. Food and Drug Administration (FDA) regulates products accounting for 20% of U.S. consumer spending. Many of its actions depend on assumptions about behavior. Will people heed food recall notices? Will they follow medication schedules? Will they have realistic expectations regarding the benefits and risks of new products? Over time, FDA has increasingly made psychology integral to its processes for answering such questions. That progress has come when windows of opportunity have found psychologists with science relevant to FDA's needs, FDA with staff who can translate that research into agency terms, and a regulatory arena that can accommodate behavioral evidence...
February 2017: American Psychologist
https://www.readbyqxmd.com/read/28220955/profiles-of-adolescent-religiousness-using-latent-profile-analysis-implications-for-psychopathology
#8
Gregory S Longo, Bethany C Bray, Jungmeen Kim-Spoon
Prior research has documented robust associations between adolescent religiousness/spirituality (R/S) and psychopathology outcomes including externalizing and internalizing symptomatology, yet no previous studies have examined these associations with adolescent R/S profiles using a person-centred approach. We examined whether there are identifiable subgroups characterized by unique multidimensional patterns of R/S experiences and how these experiences may be related to externalizing and internalizing symptomatology...
March 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/28220898/a-frailty-index-based-on-deficit-accumulation-quantifies-mortality-risk-in-humans-and-in-mice
#9
K Rockwood, J M Blodgett, O Theou, M H Sun, H A Feridooni, A Mitnitski, R A Rose, J Godin, E Gregson, S E Howlett
Although many common diseases occur mostly in old age, the impact of ageing itself on disease risk and expression often goes unevaluated. To consider the impact of ageing requires some useful means of measuring variability in health in animals of the same age. In humans, this variability has been quantified by counting age-related health deficits in a frailty index. Here we show the results of extending that approach to mice. Across the life course, many important features of deficit accumulation are present in both species...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220605/outcome-predictors-of-radical-cystectomy-in-patients-with-ct4-prostate-cancer-a-multi-institutional-study-of-62-patients
#10
Martin Spahn, Alessandro Morlacco, Silvan Boxler, Steven Joniau, Alberto Briganti, Francesco Montorsi, Paolo Gontero, Pia Bader, Detlef Frohneberg, Hein van Poppel, R Jeffrey Karnes
OBJECTIVES: To identify which patients with macroscopic bladder infiltrating T4 prostate cancer (PCa) might have favorable outcomes when treated with radical cystectomy (RC) MATERIALS AND METHODS: We evaluated 62 patients with cT4cN0-1cM0 PCa treated with RC and pelvic lymph node dissection between 1972-2011. In addition to descriptive statistics, the Kaplan-Meier method and log-rank tests were used to depict survival rates. Uni- and multivariate Cox regression analysis tested the association between predictors and progression-free, PCa-specific-, and overall survival...
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28220474/buprenorphine-for-managing-opioid-withdrawal
#11
REVIEW
Linda Gowing, Robert Ali, Jason M White, Dalitso Mbewe
BACKGROUND: Managed withdrawal is a necessary step prior to drug-free treatment or as the endpoint of substitution treatment. OBJECTIVES: To assess the effects of buprenorphine versus tapered doses of methadone, alpha2-adrenergic agonists, symptomatic medications or placebo, or different buprenorphine regimens for managing opioid withdrawal, in terms of the intensity of the withdrawal syndrome experienced, duration and completion of treatment, and adverse effects...
February 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28220459/-how-would-you-call-this-in-english-being-reflective-about-translations-in-international-cross-cultural-qualitative-research
#12
Esther Helmich, Sayra Cristancho, Laura Diachun, Lorelei Lingard
INTRODUCTION: Medical education researchers increasingly collaborate in international teams, collecting data in different languages and from different parts of the world, and then disseminating them in English-language journals. Although this requires an ever-present need to translate, it often occurs uncritically. With this paper we aim to enhance researchers' awareness and reflexivity regarding translations in qualitative research. METHODS: In an international study, we carried out interviews in both Dutch and English...
February 20, 2017: Perspectives on Medical Education
https://www.readbyqxmd.com/read/28220336/micrornas-in-model-and-complex-organisms
#13
EDITORIAL
Hikmet Budak, Baohong Zhang
Non-coding RNAs such as microRNAs (miRNAs) are very tiny ribonucleotides having an essential role in gene regulation at both post-transcriptional and translational levels. They are very conserved and expressed in worms, flies, plants, and mammals in a sequence-specific manner. Furthermore, it is now possible to clone miRNAs using the new genome editing tool CRISPR/cas9, which shows benefit in control of untargeted effect. In this special issue, we tried to cover researches associated with functional roles of miRNAs accross model and complex organisms...
February 20, 2017: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/28219641/neural-stem-cell-therapy-for-neurodegenerative-disorders-the-role-of-neurotrophic-support
#14
Samuel E Marsh, Mathew Blurton-Jones
Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease currently affect tens of millions of people worldwide. Unfortunately, as the world's population ages, the incidence of many of these diseases will continue to rise and is expected to more than double by 2050. Despite significant research and a growing understanding of disease pathogenesis, only a handful of therapies are currently available and all of them provide only transient benefits. Thus, there is an urgent need to develop novel disease-modifying therapies to prevent the development or slow the progression of these debilitating disorders...
February 17, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28219446/effective-knowledge-translation-approaches-and-practices-in-indigenous-health-research-a-systematic-review-protocol
#15
Melody E Morton Ninomiya, Donna Atkinson, Simon Brascoupé, Michelle Firestone, Nicole Robinson, Jeff Reading, Carolyn P Ziegler, Raglan Maddox, Janet K Smylie
BACKGROUND: Effective knowledge translation (KT) is critical to implementing program and policy changes that require shared understandings of knowledge systems, assumptions, and practices. Within mainstream research institutions and funding agencies, systemic and insidious inequities, privileges, and power relationships inhibit Indigenous peoples' control, input, and benefits over research. This systematic review will examine literature on KT initiatives in Indigenous health research to help identify wise and promising Indigenous KT practices and language in Canada and abroad...
February 20, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28219363/to-change-or-not-to-change-translating-and-culturally-adapting-the-paediatric-version-of-the-moral-distress-scale-revised-mds-r
#16
Margareta Af Sandeberg, Marika Wenemark, Cecilia Bartholdson, Kim Lützén, Pernilla Pergert
BACKGROUND: Paediatric cancer care poses ethically difficult situations that can lead to value conflicts about what is best for the child, possibly resulting in moral distress. Research on moral distress is lacking in paediatric cancer care in Sweden and most questionnaires are developed in English. The Moral Distress Scale-Revised (MDS-R) is a questionnaire that measures moral distress in specific situations; respondents are asked to indicate both the frequency and the level of disturbance when the situation arises...
February 20, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28218873/evaluating-internet-based-information-on-physical-activity-for-children-and-youth-with-physical-disabilities
#17
Lauren K Tristani, Rebecca Bassett-Gunter, Sunita Tanna
Parents are an important source of support for facilitating physical activity in children and youth with disabilities (CYWD). Approximately 70% of parents report using the Internet to search for information regarding their children's health. This study examined the theoretical content of physical activity information contained on publicly available Web sites targeting parents of CYWD. Web sites were amassed using Google, a combination of various search terms, and predetermined inclusion criteria. The Web sites were coded and analyzed using the content-analysis approach to the theory of specified persuasive educational communication...
January 2017: Adapted Physical Activity Quarterly: APAQ
https://www.readbyqxmd.com/read/28218850/impact-of-phosphorylation-and-pseudo-phosphorylation-on-the-early-stages-of-aggregation-of-the-microtubule-associated-protein-tau
#18
Dmitriy V Prokopovich, John W Whittaker, Micaiah M Muthee, Azka Ahmed, Luca Larini
The microtubule associated protein tau regulates the stability of microtubules within neurons in the central nervous system. In turn, microtubules are responsible for the remodeling of the cytoskeleton that ultimately leads to the formation or pruning of new connections among neurons. As a consequence, dysfunction of tau is associated with many forms of dementia as well as Alzheimer's disease. In the brain, tau activity is regulated by its phosphorylation state. Phosphorylation is a post-translational modification of proteins that adds a phosphate group to the side chain of an amino acid...
February 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28218637/mechanisms-of-chromosome-congression-during-mitosis
#19
REVIEW
Helder Maiato, Ana Margarida Gomes, Filipe Sousa, Marin Barisic
Chromosome congression during prometaphase culminates with the establishment of a metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more than 100 years of research on this topic have attempted to explain chromosome congression based on the balance between opposing pulling and/or pushing forces that reach an equilibrium near the spindle equator. However, in mammalian cells, chromosome bi-orientation and force balance at kinetochores are not required for chromosome congression, whereas the mechanisms of chromosome congression are not necessarily involved in the maintenance of chromosome alignment after congression...
February 17, 2017: Biology
https://www.readbyqxmd.com/read/28218487/radiolabelled-polymeric-materials-for-imaging-and-treatment-of-cancer-quo-vadis
#20
REVIEW
Kritee Pant, Ondřej Sedláček, Robin A Nadar, Martin Hrubý, Holger Stephan
Owing to their tunable blood circulation time and suitable plasma stability, polymer-based nanomaterials hold a great potential for designing and utilising multifunctional nanocarriers for efficient imaging and effective treatment of cancer. When tagged with appropriate radionuclides, they may allow for specific detection (diagnosis) as well as the destruction of tumours (therapy) or even customization of materials, aiming to both diagnosis and therapy (theranostic approach). This review provides an overview of recent developments of radiolabelled polymeric nanomaterials (natural and synthetic polymers) for molecular imaging of cancer, specifically, applying nuclear techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT)...
February 20, 2017: Advanced Healthcare Materials
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