keyword
https://read.qxmd.com/read/38530974/conductive-and-enhanced-mechanical-strength-of-mo-2-ti-2-c-3-mxene-based-hydrogel-promotes-neurogenesis-and-bone-regeneration-in-bone-defect-repair
#21
JOURNAL ARTICLE
Hongyu Wang, Yu-Ching Hsu, Chune Wang, Xiao Xiao, Zhengbin Yuan, Yong Zhu, Dazhi Yang
Bone defects are common with increasing high-energy fractures, tumor bone invasion, and implantation revision surgery. Bone is an electroactive tissue that has electromechanical interaction with collogen, osteoblasts, and osteoclasts. Hydrogel provides morphological plasticity and extracellular matrix (ECM) 3D structures for cell survival, and is widely used as a bone engineering material. However, the hydrogels have poor mechanical intensity and lack of cell adhesion, slow gelation time, and limited conductivity...
March 26, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38530808/macrophages-suppress-cardiac-reprogramming-of-fibroblasts-in-vivo-via-ifn-mediated-intercellular-self-stimulating-circuit
#22
JOURNAL ARTICLE
Hao Wang, Junbo Yang, Yihong Cai, Yang Zhao
Direct conversion of cardiac fibroblasts (CFs) to cardiomyocytes (CMs) in vivo to regenerate heart tissue is an attractive approach. After myocardial infarction (MI), heart repair proceeds with an inflammation stage initiated by monocytes infiltration of the infarct zone establishing an immune microenvironment. However, whether and how the MI microenvironment influences the reprogramming of CFs remains unclear. Here, we found that in comparison with cardiac fibroblasts (CFs) cultured in vitro, CFs that transplanted into infarct region of MI mouse models resisted to cardiac reprogramming...
March 26, 2024: Protein & Cell
https://read.qxmd.com/read/38529321/molecular-regulation-of-transforming-growth-factor-%C3%AE-1-induced-thioredoxin-interacting-protein-ubiquitination-and-proteasomal-degradation-in-lung-fibroblasts-implication-in-pulmonary-fibrosis
#23
JOURNAL ARTICLE
Sarah J Taleb, Qinmao Ye, Boina Baoyinna, Michael Dedad, Dakshin Pisini, Narasimham L Parinandi, Lewis C Cantley, Jing Zhao, Yutong Zhao
Thioredoxin-interacting protein (TXNIP) plays a critical role in regulation of cellular redox reactions and inflammatory responses by interacting with thioredoxin (TRX) or the inflammasome. The role of TXNIP in lung fibrosis and molecular regulation of its stability have not been well studied. Therefore, here we investigated the molecular regulation of TXNIP stability and its role in TGF-β1-mediated signaling in lung fibroblasts. TXNIP protein levels were significantly decreased in lung tissues from bleomycin-challenged mice...
March 2024: J Respir Biol Transl Med
https://read.qxmd.com/read/38529291/connexin-43-in-the-function-and-homeostasis-of-osteocytes-a-narrative-review
#24
REVIEW
Liang Ma, Wenzhao Wang, Guixuan Xu, Hao Li, Fei Liu, Huarong Shao, Xiuhua Zhang, Yuxia Ma, Gang Li, Hui Li, Shuzhong Gao, Peixue Ling
BACKGROUND AND OBJECTIVE: Connexin 43 (Cx43) is the main gap junction (GJ) protein and hemichannel protein in bone tissue. It is involved in the formation of hemichannels and GJs and establishes channels that can communicate directly to exchange substances and signals, affecting the structure and function of osteocytes. CX43 is very important for the normal development of bone tissue and the establishment and balance of bone reconstruction. However, the molecular mechanisms by which CX43 regulates osteoblast function and homeostasis have been less well studied, and this article provides a review of research in this area...
2024: Annals of joint
https://read.qxmd.com/read/38528729/indole-3-acetic-acid-alleviates-dss-induced-colitis-by-promoting-the-production-of-r-equol-from-bifidobacterium-pseudolongum
#25
JOURNAL ARTICLE
Miaomiao Li, Xue Han, Lijun Sun, Xinjuan Liu, Weizhen Zhang, Jianyu Hao
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by immune-mediated, chronic inflammation of the intestinal tract. The occurrence of IBD is driven by the complex interactions of multiple factors. The objective of this study was to evaluate the therapeutic effects of IAA in colitis. METHOD: C57/BL6 mice were administered 2.5% DSS in drinking water to induce colitis. IAA, Bifidobacterium pseudolongum, and R-equol were administered by oral gavage and fed a regular diet...
2024: Gut Microbes
https://read.qxmd.com/read/38528715/low-density-lipoprotein-receptor-related-protein-5-6-promotes-endometrial-cancer-progression-and-cancer-cell-immune-escape
#26
JOURNAL ARTICLE
Lifan Shen, Chen Zhang, Genhai Zhu
The study investigated the potential association of the low-density lipoprotein (LDL) genome with endometrial cancer progression based on the Gene Expression Omnibus data set and The Cancer Genome Atlas data set. Differential and weighted gene coexpression network analysis was performed on endometrial cancer transcriptome datasets GSE9750 and GSE106191. The protein-protein interaction network was built using LDL-receptor proteins and the top 50 tumor-associated genes. Low-density lipoprotein-related receptors 5/6 (LRP5/6) in endometrial cancer tissues were correlated with oncogenes, cell cycle-related genes, and immunological checkpoints using Spearman correlation...
April 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38528582/lncrna-wfdc21p-interacts-with-sec63-to-promote-gastric-cancer-malignant-behaviors-by-regulating-calcium-homeostasis-signaling-pathway
#27
JOURNAL ARTICLE
Jinyao Dong, Yongqiang Lv, Debin Meng, Ruyi Shi, Feng Li, Rui Guo, Yi Wang, Jiansheng Guo, Yanyan Zhang
BACKGROUND: Gastric cancer is currently estimated to be the fifth leading common cancer in the world, and responsible for about one million new cases and an estimated 769,000 cancer-related deaths each year. WFDC21P is long non-coding RNA and has been reported to play critical roles in serval types of cancer. Our research aims to investigate the biological effects and molecular mechanism of WFDC21P in gastric cancer. METHODS: Datasets (GSE53137, GSE58828, and GSE109476) in GEO database were used to screen differential expressed lncRNAs in gastric cancer by online GEO2R analysis tool...
March 25, 2024: Cancer Cell International
https://read.qxmd.com/read/38528516/peli1-key-players-in-the-oncogenic-characteristics-of-pancreatic-cancer
#28
JOURNAL ARTICLE
Xiaobin Fei, Changhao Zhu, Peng Liu, Songbai Liu, Likun Ren, Rishang Lu, Junyi Hou, Yongjia Gao, Xing Wang, Yaozhen Pan
BACKGROUND: Pancreatic cancer (PC) is a highly malignant gastrointestinal tumor, which is characterized by difficulties in early diagnosis, early metastasis, limited therapeutic response and a grim prognosis. Therefore, it is imperative to explore potential therapeutic targets for PC. Currently, although the involvement of the Pellino E3 Ubiquitin Protein Ligase 1 (PELI1) in the human growth of some malignant tumors has been demonstrated, its association with PC remains uncertain. METHODS: Bioinformatics, qRT-PCR, Western blot and IHC were used to detect the expression of PELI1 in pancreas or PC tissues and cells at mRNA and protein levels...
March 25, 2024: Journal of Experimental & Clinical Cancer Research: CR
https://read.qxmd.com/read/38527672/analysis-of-differentially-expressed-lncrnas-and-mrnas-associated-with-slow%C3%A2-transit-constipation
#29
JOURNAL ARTICLE
Yuanxin Miao, Xiongwei Xie, Yonglian Zhang, Xu Ma, Xiaoxuan Zhu, Rong Li, Jinhua Bi, Rui Duan, Xu Ai
Slow transit constipation (STC) is a refractory gastrointestinal disease, accounting for approximately 13 ∼ 37 % of chronic constipation. However, the molecular mechanism of STC remains poorly understood. Herein, this study aims to identify the key mRNAs and lncRNAs associated with STC. To this end, we performed high-throughput RNA sequencing to identify differentially expressed (DE) mRNAs and lncRNAs in the whole-layer sigmoid intestinal tissues from 4 STC patients and 4 non-STC patients...
March 23, 2024: Gene
https://read.qxmd.com/read/38526797/imaging-mass-cytometry-for-in-situ-immune-profiling
#30
JOURNAL ARTICLE
Kevin Hu, Andrew Harman, Heeva Baharlou
The complexities and cellular heterogeneity associated with tissues necessitate the concurrent detection of markers beyond the limitations of conventional imaging approaches in order to spatially resolve the relationships between immune cell populations and their environments. This is a necessary complement to single-cell suspension-based methods to inform a better understanding of the events that may underlie pathological conditions. Imaging mass cytometry is a high-dimensional imaging modality that allows for the concurrent detection of up to 40 protein markers of interest across tissues at subcellular resolution...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38526177/oncogenic-roles-of-laminin-subunit-gamma-2-in-intrahepatic-cholangiocarcinoma-via-promoting-egfr-translation
#31
JOURNAL ARTICLE
Jianjuan Zhang, Fubo Ji, Yaqi Tan, Lei Zhao, Yongzhi Zhao, Jiaxin Liu, Liyuan Shao, Jiong Shi, Meihua Ye, Xianglei He, Jianping Jin, Bin Zhao, Jun Huang, Stephanie Roessler, Xin Zheng, Junfang Ji
Intrahepatic cholangiocarcinoma (iCCA) is a highly lethal biliary epithelial cancer in the liver. Here, Laminin subunit gamma-2 (LAMC2) with important oncogenic roles in iCCA is discovered. In a total of 231 cholangiocarcinoma patients (82% of iCCA patients) across four independent cohorts, LAMC2 is significantly more abundant in iCCA tumor tissue compared to normal bile duct and non-tumor liver. Among 26.3% of iCCA patients, LAMC2 gene is amplified, contributing to its over-expression. Functionally, silencing LAMC2 significantly blocks tumor formation in orthotopic iCCA mouse models...
March 25, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38524870/tibial-cortex-transverse-transport-regulates-orai1-stim1-mediated-no-release-and-improve-the-migration-and-proliferation-of-vessels-via-increasing-osteopontin-expression
#32
JOURNAL ARTICLE
Lingchao Kong, Yangyang Li, Zhongfang Deng, Xiaoyu Chen, Yin Xia, Bing Shen, Rende Ning, Lesha Zhang, Zongsheng Yin
BACKGROUND: Diabetic foot is a major complication of diabetes. The bone transverse transport method could be applied in clinics for treatment, which could improve the metabolism of the tissues via lasting distraction forces. However, the process' specific regulating mechanism is still unknown. METHODS: Based on the notion that the healing of bones involves the recruitment of calcium ions, in this study, we established the model of tibial cortex transverse transport (TTT) on rats and then used tissue immunologic detection, such as the double fluorescent staining to explore the expression of the calcium channels' calcium release-activated calcium modulator 1 (Orai1)/stromal interaction molecule 1 (STIM1), which belong to the store-operated calcium entry (SOCE) signaling pathways on the tissues around the bone transport area...
March 2024: Journal of Orthopaedic Translation
https://read.qxmd.com/read/38523597/circitga7-regulates-malignant-phenotypes-in-bladder-cancer-cells-via-targeting-mir-330-3p-klf10-axis
#33
JOURNAL ARTICLE
Xian-Xu Yang, Chao Wang
Bladder cancer (BCa) is one of the common malignancies. Circular RNAs (circRNAs) play regulatory roles in cancer progression. CircITGA7 is a circRNA generated from several exons of ITGA7. The potential role of circITGA7 in BCa remains unknown and needs to be explored. Quantitative real time polymerase chain reaction (qRT-PCR) was used to assess circITGA7 and miR-330-3p expression in BCa tissues and cell lines. Kaplan-Meier analysis was used to evaluate the overall survival of these BCa patients. The biological function of circITGA7 was examined by overexpression of circITGA7 using CCK-8, EdU, wound-healing, and Transwell assays...
March 25, 2024: Kaohsiung Journal of Medical Sciences
https://read.qxmd.com/read/38522525/effects-of-chronic-cr-and-ni-co-exposure-on-liver-inflammation-and-autophagy-in-mice-by-regulating-the-tlr4-mtor-pathway
#34
JOURNAL ARTICLE
Xianhong Cao, Shuangyan Zheng, Yizhou Zeng, Yan Shi, Jun Du, Cheng Huang, Yufan Shen, Ping Liu, Xiaoquan Guo, Xiaona Gao
Exposure to Cr and/or Ni can have widespread implications on the environment and health. However, the specific toxic effects of chronic Cr and Ni co-exposure on mice liver have not been reported. To ascertain the combined toxic effects of chronic Cr and Ni co-exposure on liver damage in mice, 80 6-week-old female C57BL/6 J mice were randomly divided into 4 groups: the Con group, Cr group (Cr+6 50 mg/L), Ni group (Ni+2 110 mg/L), and Cr + Ni group (Cr+6 50 mg/L + Ni+2 110 mg/L)...
March 22, 2024: Science of the Total Environment
https://read.qxmd.com/read/38522511/stabilization-of-interdomain-interactions-in-g-protein-%C3%AE-subunits-as-a-determinant-of-g%C3%AE-i-subtype-signaling-specificity
#35
JOURNAL ARTICLE
Tyler J Lefevre, Wenyuan Wei, Elizaveta Mukhaleva, Sai Pranathi Meda Venkata, Naincy R Chandan, Saji Abraham, Yong Li, Carmen W Dessauer, Nagarajan Vaidehi, Alan V Smrcka
Highly homologous members of the Gαi family, Gαi1-3 , have distinct tissue distributions and physiological functions, yet their biochemical and functional properties are very similar. We recently identified PDZ-RhoGEF (PRG) as a novel Gαi1 effector that is poorly activated by Gαi2 . In a proteomic proximity labeling screen we observed a strong preference for Gαi1 relative to Gαi2 with respect to engagement of a broad range of potential targets. We investigated the mechanistic basis for this selectivity using PRG as a representative target...
March 22, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38521771/ripk1-inhibitor-ameliorates-pulmonary-injury-by-modulating-the-function-of-neutrophils-and-vascular-endothelial-cells
#36
JOURNAL ARTICLE
Tao Yang, Cai-Gui Xiang, Xiao-Han Wang, Qing-Qing Li, Shu-Yue Lei, Kai-Rong Zhang, Jing Ren, Hui-Min Lu, Chun-Lan Feng, Wei Tang
Acute lung injury (ALI) is an acute and progressive hypoxic respiratory failure that could progress to acute respiratory distress syndrome (ARDS) with a high mortality rate, thus immediate medical attention and supportive care are necessary. The pathophysiology of ALI is characterized by the disruption of the alveolar-capillary barrier and activation of neutrophils, leading to lung tissue damage. The receptor-interacting protein kinase 1 (RIPK1) has emerged as a promising target for the treatment of multiple inflammatory diseases, but the role of RIPK1 in the ALI remains poorly understood...
March 23, 2024: Cell Death Discovery
https://read.qxmd.com/read/38521378/a-novel-c-type-lectin-protein-bjctl5-interacts-with-apoptosis-stimulating-proteins-of-p53-aspp-to-activate-nf-%C3%AE%C2%BAb-signaling-pathway-in-primitive-chordate
#37
JOURNAL ARTICLE
Wenyu Fan, Jianing Chen, Yunpeng Cao, Jiabo Tan, Jinlong Li, Su Wang, Ping Jin, Xiaojun Song
C-type lectin proteins (CTLs), a group of pattern recognition receptors (PRRs), play pivotal roles in immune responses. However, the signal transduction and regulation of CTLs in cephalochordates have yet to be explored. In this study, we examined the composition of CTLs in Branchiostoma japonicum, identifying a total of 272 CTLs. These CTLs underwent further analysis concerning domain arrangement, tandem and segmental duplication events. A multidomain C-type lectin gene, designated as BjCTL5, encompassing CLECT, KR, CUB, MAM, and SR domains, was the focal point of our investigation...
March 21, 2024: Developmental and Comparative Immunology
https://read.qxmd.com/read/38520914/combined-set7-9-and-cdk4-inhibition-act-synergistically-against-osteosarcoma
#38
JOURNAL ARTICLE
Yingxu Shi, Zhonghao Wang, Yiming Shao, Qianqian Guang, Jian Zhang, Baorui Liu, Chunshen Wu, Yexin Wang, Ping Sui
Osteosarcoma is the most common malignant bone tumor. It has a poor prognosis because of a lack of therapeutic targets and strategies. The SET domain-containing lysine-specific methyltransferase, SET7/9, has various functions in different cancer types in tissue-type and signaling context-dependent manners. The role of SET7/9 in osteosarcoma cells is currently controversial and its potential as a therapeutic candidate in osteosarcoma is unknown. In the present study, SET7/9 inhibition or ablation suppressed osteosarcoma cell proliferation by causing G1 arrest...
March 20, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38520835/molecular-mechanisms-of-codonopsis-pilosula-in-inhibiting-hepatocellular-carcinoma-growth-and-metastasis
#39
JOURNAL ARTICLE
Ning Li, Ce Yang, Jing Xia, Wenxiang Wang, Wei Xiong
BACKGROUND: Liver cancer, one of the most common types of cancer worldwide, accounts for millions of cases annually. With its multi-target and wide-ranging therapeutic effects, traditional Chinese medicine has emerged as a potential approach for treating various tumors. Codonopsis pilosula, a traditional herb, is known for its anti-inflammatory and antioxidant properties. In this study, we investigated the potential molecular mechanisms of Codonopsis pilosula in regulating the inhibition of CDK1 and the modulation of PDK1/β-catenin, which are involved in hepatocellular carcinoma growth and metastasis...
January 7, 2024: Phytomedicine
https://read.qxmd.com/read/38520741/pah-deficient-pathology-in-humanized-c-1066-11g-a-phenylketonuria-mice
#40
JOURNAL ARTICLE
Ainhoa Martínez-Pizarro, Sara Picó, Arístides López-Márquez, Claudia Rodriguez-López, Elena Montalvo, Mar Alvarez, Margarita Castro, Santiago Ramón-Maiques, Belén Pérez, José J Lucas, Eva Richard, Lourdes R Desviat
We have generated using CRISPR/Cas9 technology a partially humanized mouse model of the neurometabolic disease phenylketonuria (PKU), carrying the highly prevalent PAH variant c.1066-11G>A. This variant creates an alternative 3' splice site, leading to the inclusion of 9 nucleotides coding for 3 extra amino acids between Q355 and Y356 of the protein. Homozygous Pah c.1066-11A mice, with a partially humanized intron 10 sequence with the variant, accurately recapitulate the splicing defect and present almost undetectable hepatic PAH activity...
March 23, 2024: Human Molecular Genetics
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