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Tissue protein interactions

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https://www.readbyqxmd.com/read/29777321/how-changes-in-interconnectivity-affect-the-bulk-properties-of-articular-cartilage-a-fibre-network-study
#1
M A Bilton, A Thambyah, R J Clarke
The remarkable compressive strength of articular cartilage arises from the mechanical interactions between the tension-resisting collagen fibrils and swelling proteoglycan proteins within the tissue. These interactions are facilitated by a significant level of interconnectivity between neighbouring collagen fibrils within the extracellular matrix. A reduction in interconnectivity is suspected to occur during the early stages of osteoarthritic degeneration. However, the relative contribution of these interconnections towards the bulk mechanical properties of articular cartilage has remained an open question...
May 18, 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29776603/regulation-of-g-protein-%C3%AE-%C3%AE-signaling
#2
Kanishka Senarath, Dinesh Kankanamge, Saroopa Samaradivakara, Kasun Ratnayake, Mithila Tennakoon, Ajith Karunarathne
Heterotrimeric guanine nucleotide-binding proteins (G proteins) deliver external signals to the cell interior, upon activation by the external signal stimulated G protein-coupled receptors (GPCRs).While the activated GPCRs control several pathways independently, activated G proteins control the vast majority of cellular and physiological functions, ranging from vision to cardiovascular homeostasis. Activated GPCRs dissociate GαGDPβγ heterotrimer into GαGTP and free Gβγ. Earlier, GαGTP was recognized as the primary signal transducer of the pathway and Gβγ as a passive signaling modality that facilitates the activity of Gα...
2018: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/29776413/the-cxcr4-antagonist-plerixafor-amd3100-promotes-proliferation-of-ewing-sarcoma-cell-lines-in-vitro-and-activates-receptor-tyrosine-kinase-signaling
#3
Philipp Berning, Christiane Schaefer, Dagmar Clemens, Eberhard Korsching, Uta Dirksen, Jenny Potratz
BACKGROUND: The CXCR4 receptor antagonist plerixafor (AMD3100) is raising interest as an anti-cancer agent that disrupts the CXCL12-CXCR4 chemokine - receptor interaction between neoplastic cells and their microenvironment in tumor progression and metastasis. Here, we investigated plerixafor for anti-cancer activity in Ewing sarcoma, a rare and aggressive cancer of bone and soft tissues. METHODS: We used a variety of methods such as cell viability and migration assays, flow cytometry, phospho-tyrosine arrays and western blotting to determine plerixafor effects on five characterized Ewing sarcoma cell lines and a low-passage culture in vitro...
May 18, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29775862/identification-and-functional-characterization-of-a-max2-ortholog-from-switchgrass-panicum-virgatum-l
#4
Tingting Cheng, Donghua Wang, Yongfeng Wang, Shumeng Zhang, Chao Zhang, Shudong Liu, Yajun Xi, Fengli Sun
Switchgrass (Panicum virgatum L.) is a sustainable cellulosic energy crop with high biomass yield on marginal soils. Tillering, an important agronomic characteristic related to biomass production in gramineous plants, is regulated by complex interacting factors, such as plant hormones. Strigolactones (SLs) comprise a novel class of plant hormones that inhibit shoot branching. The MORE AXILLARY GROWTH2 (MAX2)/DWARF 3 (D3)/RAMOSUS (RMS4) genes encode proteins involved in the SL signaling pathway in various plants...
May 15, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29775758/lncrna-prncr1-regulates-osteogenic-differentiation-in-osteolysis-after-hip-replacement-by-targeting-mir-211-5p
#5
Zong-Ming Gong, Zhen-Yu Tang, Xiao-Liang Sun
BACKGROUND: Osteogenic differentiation and osteolysis after hip replacement are both associated with bone metabolism. Interaction between lncRNA PRNCR1 and miR-211-5p was analyzed to illuminate their roles in osteogenic differentiation and osteolysis. METHODS: The expression of PRNCR1, miR-211-5p and C-X-C chemokine receptor-4 (CXCR4) protein in tissues and mesenchymal stem cells (MSCs) were determined by qRT-PCR and Western blot, separately. The osteogenic differentiation was assessed by ALP activity detection and ARS staining...
May 15, 2018: Gene
https://www.readbyqxmd.com/read/29775610/monocarboxylate-transporters-in-breast-cancer-and-adipose-tissue-are-novel-biomarkers-and-potential-therapeutic-targets
#6
Zhiyu Li, Qi Wu, Si Sun, Juan Wu, Juanjuan Li, Yimin Zhang, Changhua Wang, Jingping Yuan, Shengrong Sun
Monocarboxylate transporters (MCTs) are transmembrane proteins that control the lactate metabolism and associated with poor prognosis in solid tumors including breast cancer (BC). This study aimed to evaluate the clinical and prognostic value of MCTs used by immunohistochemistry and quantum dots-based fluorescent imaging technique in BC and surrounding stroma with emphasis on the interaction between tumour and stroma. Moreover, the data from The Cancer Genome Atlas (TCGA) was analyzed to evaluate the association between MCTs mRNA expression and prognosis of breast cancer patients...
May 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29775412/inhibitor-of-lysyl-oxidase-improves-cardiac-function-and-the-collagen-mmp-profile-in-response-to-volume-overload
#7
Elia C El Hajj, Milad C El Hajj, Van K Ninh, Jason D Gardner
The cardiac extracellular matrix is a complex architectural network that serves many functions including providing structural and biochemical support to surrounding cells, and regulating intercellular signaling pathways. Cardiac function is directly affected by extracellular matrix (ECM) composition, and alterations of the ECM contribute to progression of heart failure. Initially, collagen deposition is an adaptive response that aims to preserve tissue integrity and maintain normal ventricular function. However, the synergistic effects of the pro-inflammatory and pro-fibrotic responses induce a vicious cycle which causes excess activation of myofibroblasts, significantly increasing collagen deposition and accumulation in the matrix...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29775410/apelin-and-apj-orchestrate-complex-tissue-specific-control-of-cardiomyocyte-hypertrophy-and-contractility-in-the-hypertrophy-heart-failure-transition
#8
Victoria Nicole Parikh, Jing Liu, Ching Shang, Christopher Woods, Alex Chia Yu Chang, Mingming Zhao, David N Charo, Zachary Grunwald, Yong Huang, Kinya Seo, Philip S Tsao, Daniel Bernstein, Pilar Ruiz-Lozano, Thomas Quertermous, Euan A Ashley
The G protein coupled receptor APJ is a promising therapeutic target for heart failure. Constitutive deletion of APJ in the mouse is protective against the hypertrophy-heart failure transition via elimination of ligand-independent, β-arrestin dependent stretch transduction. However, the cellular origin of this stretch transduction and the details of its interaction with apelin signaling remain unknown. We generated mice with conditional elimination of APJ in the endothelium (APJendo-/- ) and myocardium (APJmyo-/- )...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29774633/a-simple-and-cost-efficient-adherent-culture-platform-for-human-gastric-primary-cells-as-an-in-vitro-model-for-helicobacter-pylori-infection
#9
Samaneh Saberi, Behshad Pournasr, Zahra Farzaneh, Maryam Esmaeili, Mahmoud Eshagh Hosseini, Hossein Baharvand, Marjan Mohammadi
BACKGROUND: Most two- dimensional in vitro models for studying host- H. pylori interactions rely on tumor-derived cell lines, which harbor malignant alterations. The recent development of human gastric organoids has overcome this limitation and provides a highly sophisticated, yet costly, short-term model for H. pylori infection, with restricted use in low-budget centers. METHOD: Tissue specimens from upper, middle, and lower stomachs of H. pylori-negative volunteers were collectively dispersed and cultured on mouse embryonic fibroblast (MEF) or collagen-coated plates...
May 17, 2018: Helicobacter
https://www.readbyqxmd.com/read/29774565/local-and-systemic-regulation-of-psii-efficiency-in-triticale-infected-by-the-hemibiotrophic-pathogen-microdochium-nivale
#10
Mateusz Dyda, Iwona Wąsek, Mirosław Tyrka, Maria Wędzony, Magdalena Szechyńska-Hebda
Microdochium nivale is a fungal pathogen that causes yield losses of cereals during winter. Cold hardening under light conditions induces genotype-dependent resistance of a plant to infection. We aim to show how photosystem II (PSII) regulation contributes to plant resistance. Using mapping population of triticale doubled haploid lines, three M. nivale strains and different infection assays, we demonstrate that plants that maintain a higher maximum quantum efficiency of PSII show less leaf damage upon infection...
May 17, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29774448/the-expression-alteration-of-bc1-rna-and-its-interaction-with-eukaryotic-translation-initiation-factor-eif4a-post-status-epilepticus
#11
Xiangchang Zeng, Wenjing Zong, Qing Gao, Siyu Chen, Lulu Chen, Guirong Zeng, Weihua Huang, Zhenyu Li, Chang Zeng, Yuanyuan Xie, Xiaohui Li, Bo Xiao, Dongsheng-Ouyang, Kai Hu
Abnormal dendritic sprouting and synaptic remodelling are important pathological features of temporal lobe epilepsy. BC1 RNA is a translation repressor involved in the regulation of the dendritic protein synthesis and mRNA transport, which is essential for dendritic development and plasticity. The expression alteration of BC1 RNA in the pilocarpine induced epilepsy model remains unknown. It is unclear if the interactions between BC1 RNA and eukaryotic initiation factor 4A (eIF4A) exists in this model. The purpose of this study was to investigate the expression changes of BC1 RNA and its interactions with eIF4A post-status epilepticus (SE)...
May 17, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29773901/ets-1-promoter-associated-noncoding-rna-regulates-the-nono-erg-ets-1-axis-to-drive-gastric-cancer-progression
#12
Dan Li, Yajun Chen, Hong Mei, Wanju Jiao, Huajie Song, Lin Ye, Erhu Fang, Xiaojing Wang, Feng Yang, Kai Huang, Liduan Zheng, Qiangsong Tong
Emerging studies have indicated the essential functions of long noncoding RNAs (lncRNAs) during cancer progression. However, whether lncRNAs contribute to the upregulation of v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets-1), an established oncogenic protein facilitating tumor invasion and metastasis, in gastric cancer remains elusive. Herein, we identified Ets-1 promoter-associated noncoding RNA (pancEts-1) as a novel lncRNA associated with the gastric cancer progression via mining of publicly available datasets and rapid amplification of cDNA ends...
May 18, 2018: Oncogene
https://www.readbyqxmd.com/read/29773398/sulfated-polysaccharide-mediated-tgf-%C3%AE-1-presentation-in-pre-formed-injectable-scaffolds-for-cartilage-tissue-engineering
#13
Neha Ashok Waghmare, Aditya Arora, Arijit Bhattacharjee, Dhirendra S Katti
In this work, a plant-derived polysaccharide carboxymethylcellulose (CMC) was chemically modified to incorporate sulfate groups to facilitate binding of cationic growth factors. The sulfated CMC (heparin mimic) was then used with CMC (glycosaminoglycan mimic) and gelatin (collagen mimic) to fabricate injectable pre-formed, macroporous scaffolds for cartilage tissue engineering. These scaffolds demonstrated high resilience and shape memory, thereby making them injectable through a 14G needle for up to 4-6 aspiration and injection cycles...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29773186/association-between-cadmium-and-androgen-receptor-protein-expression-differs-in-prostate-tumors-of-african-american-and-european-american-men
#14
Christine M Neslund-Dudas, Russell B McBride, Ashoka Kandegedara, Benjamin A Rybicki, Oleksandr N Kryvenko, Dhananjay Chitale, Nilesh Gupta, Sean R Williamson, Craig G Rogers, Carlos Cordon-Cardo, Andrew G Rundle, Albert M Levin, Q Ping Dou, Bharati Mitra
Cadmium is a known carcinogen that has been implicated in prostate cancer, but how it affects prostate carcinogenesis in humans remains unclear. Evidence from basic science suggests that cadmium can bind to the androgen receptor causing endocrine disruption. The androgen receptor is required for normal prostate development and is the key driver of prostate cancer progression. In this study, we examined the association between cadmium content and androgen receptor protein expression in prostate cancer tissue of African American (N = 22) and European American (N = 30) men...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29771420/imp3-promotes-tnbc-stem-cell-property-through-mirna-34a-regulation
#15
Q-D Huang, S-R Zheng, Y-J Cai, D-L Chen, Y-Y Shen, C-Q Lin, X-Q Hu, X-H Wang, H Shi, G-L Guo
OBJECTIVE: To explore the expression and function of insulin-like growth factor II (IGFII) mRNA binding protein (IMP3) in the Triple Negative Breast Cancer (TNBC). MATERIALS AND METHODS: According to previously reported gene expression array, we found that IMP3 had significantly higher expression in the CD44+CD24-ESA+ cell cluster, tumor initiating cell or cancer stem cell (CSCs), compared to other tumor cells. Based on the GEO database (GEO accession No. GSE6883), we detected the mRNA levels of IMP 1,2 and 3 by quantitative polymerase chain reaction (q-PCR) in CD44+CD24-ESA+ cell cluster and other breast tumor cell clusters...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29771033/-the-effects-and-expression-of-survivin-and-aurora-b-in-laryngeal-carcinoma
#16
C H Hu, W H Wang, Q Wang, X S He
Objective: The aim of this study is to investigate the relationship between the expression of Survivin and Aurora-b in laryngeal carcinoma and its clinical and pathological features, and to determine the possibility of Survivin and Aurora-b being a biomarker in laryngeal carcinoma diagnosis or being an predictor of overall survival (OS) in laryngeal carcinoma patients underwent surgical resection. Method: Eighty-six cases of laryngeal carcinoma tissues diagnosed by pathology were collected, and 86 cases of adjacent tissues and 22 cases of normal tissues were selected as control...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29769532/aid-apobec-like-cytidine-deaminases-are-ancient-innate-immune-mediators-in-invertebrates
#17
Mei-Chen Liu, Wen-Yun Liao, Katherine M Buckley, Shu Yuan Yang, Jonathan P Rast, Sebastian D Fugmann
In the course of both innate and adaptive immunity, cytidine deaminases within the activation induced cytidine deaminase (AID)/apolipoprotein B editing complex (APOBEC) family modulate immune responses by mutating specific nucleic acid sequences of hosts and pathogens. The evolutionary emergence of these mediators, however, seems to coincide precisely with the emergence of adaptive immunity in vertebrates. Here, we show a family of genes in species within two divergent invertebrate phyla-the echinoderm Strongylocentrotus purpuratus and the brachiopod Lingula anatina-that encode proteins with similarities in amino acid sequence and enzymatic activities to the vertebrate AID/APOBECs...
May 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29769388/lineage-tracing-and-fate-mapping-in-xenopus-embryos
#18
Sally A Moody
Fate mapping approaches reveal what types of cells, tissues, and organs are derived from specific embryonic cells. Classical fate maps were made by microscopic techniques using embryos comprising small numbers of transparent cells. More complex and opaque embryos require use of a vital or lipophilic dye that labels small groups of cells. Intracellular injection of a lineage tracer that labels the injected cell and all of its descendants can be used to mark a single cell in Xenopus embryos, whose large cells are easy to microinject and usually cleave in regular patterns...
May 16, 2018: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/29768199/the-autism-related-protein-chd8-cooperates-with-c-ebp%C3%AE-to-regulate-adipogenesis
#19
Yasuyuki Kita, Yuta Katayama, Taichi Shiraishi, Takeru Oka, Tetsuya Sato, Mikita Suyama, Yasuyuki Ohkawa, Keishi Miyata, Yuichi Oike, Michiko Shirane, Masaaki Nishiyama, Keiichi I Nakayama
The gene encoding the chromatin remodeler CHD8 is the most frequently mutated gene in individuals with autism spectrum disorder (ASD). Heterozygous mutations in CHD8 give rise to ASD that is often accompanied by macrocephaly, gastrointestinal complaints, and slender habitus. Whereas most phenotypes of CHD8 haploinsufficiency likely result from delayed neurodevelopment, the mechanism underlying slender habitus has remained unknown. Here, we show that CHD8 interacts with CCAAT/enhancer-binding protein β (C/EBPβ) and promotes its transactivation activity during adipocyte differentiation...
May 15, 2018: Cell Reports
https://www.readbyqxmd.com/read/29767447/expression-of-ribosomal-and-actin-network-proteins-and-immunochemotherapy-resistance-in-diffuse-large-b-cell-lymphoma-patients
#20
Susanne Bram Ednersson, Martin Stenson, Mimmie Stern, Gunilla Enblad, Henrik Fagman, Herman Nilsson-Ehle, Sverker Hasselblom, Per-Ola Andersson
Diffuse large B cell lymphoma (DLBCL) patients with early relapse or refractory disease have a very poor outcome. Immunochemotherapy resistance will probably, also in the era of targeted drugs, remain the major cause of treatment failure. We used proteomic mass spectrometry to analyse the global protein expression of micro-dissected formalin-fixed paraffin-embedded tumour tissues from 97 DLBCL patients: 44 with primary refractory disease or relapse within 1 year from diagnosis (REF/REL), and 53 who were progression-free more than 5 years after diagnosis (CURED)...
May 16, 2018: British Journal of Haematology
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