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https://www.readbyqxmd.com/read/27922139/are-low-sun-exposure-and-or-vitamin-d-risk-factors-for-type-1-diabetes
#1
K M Miller, P H Hart, N H de Klerk, E A Davis, R M Lucas
The global variation in type 1 diabetes (T1D) incidence rates is one of the most significant observed for any non-communicable disease. Geographical patterns in incidence suggest that low sun exposure may contribute to the wide disparity, with incidence rates generally increasing with distance from the Equator. T1D development is associated with hyperactivity of the adaptive immune system leading to autoimmune destruction of insulin-secreting pancreatic β cells. Both exposure to ultraviolet radiation (UVR) and vitamin D, with their known immunosuppressive effects, have the potential to delay or inhibit the disease...
December 6, 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/27921322/the-heterophoria-of-3-5-year-old-children-as-a-function-of-viewing-distance-and-target-type
#2
Mary E Troyer, Vidhyapriya Sreenivasan, T J Peper, T Rowan Candy
PURPOSE: Heterophoria is the misalignment of the eyes in monocular viewing and represents the accuracy of vergence driven by all classical cues except disparity. It is challenging to assess restless children using clinical cover tests, and phoria in early childhood is poorly understood. Here we used eye tracking to assess phoria as a function of viewing distance and target in adults and young children, with comparison to clinical cover tests. METHODS: Purkinje image tracking (MCS PowerRefractor) was used to record eye alignment in adults (19-28 years, N = 24) and typically developing children (3-5 years, N = 24)...
December 5, 2016: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/27921225/dimensional-changes-in-the-kolahoi-glacier-from-1857-to-2014
#3
Aparna Shukla, Iram Ali, Nazia Hasan, Shakil A Romshoo
This study assimilates data from historical records (1857-1961/84), survey of India topographic maps, and a series of multispectral satellite data (1962-2014) for analyzing the shrinkage and dimensional changes of the Kolahoi glacier, Jammu and Kashmir, between 1857 and 2014. The composite results show that the glacier has receded by ∼3423 m (21.8 m/year) in the past 157 years. The historical records reveal that the glacier retreated by >1609 m from 1857 to 1909, 800 m from 1912 to 1961, and 210 m from 1961 to 1984...
December 2016: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27921037/acute-kidney-injury-in-western-countries
#4
REVIEW
Josée Bouchard, Ravindra L Mehta
BACKGROUND: Acute kidney injury (AKI) is frequent and is associated with poor outcomes, including increased mortality, higher risk of chronic kidney disease, and prolonged hospital lengths of stay. The epidemiology of AKI mainly derives from studies performed in Western high-income countries. More limited data are available from Western low-income and middle-income countries (LMICs) located in Central and South America. SUMMARY: In this review, we summarize the most recent data on the epidemiology of AKI in Western countries, aiming to contrast results from industrialized high-income countries with LMICs...
October 2016: Kidney Diseases
https://www.readbyqxmd.com/read/27920972/potentially-preventable-hospitalizations-for-acute-and-chronic-conditions-in-alaska-2010-2012
#5
Prabhu P Gounder, Sara M Seeman, Robert C Holman, Alice Rarig, Mary K McEwen, Claudia A Steiner, Michael L Bartholomew, Thomas W Hennessy
OBJECTIVE: The U.S. Agency for Healthcare Research and Quality's Prevention Quality Indicators comprise acute and chronic conditions for which hospitalization can be potentially prevented by high-quality ambulatory care. The Healthy Alaska 2020 initiative (HA2020) targeted reducing potentially preventable hospitalizations (PPH) for acute and chronic conditions among its health indicators. We estimated the PPH rate for adults aged ≥ 18 years in Alaska during 2010-2012. METHODS: We conducted a cross-sectional analysis of state-wide hospital discharge data obtained from the Healthcare Cost and Utilization Project and the Indian Health Service...
December 2016: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27920944/comparing-obesity-related-health-disparities-among-native-hawaiians-pacific-islanders-asians-and-whites-in-california-reinforcing-the-need-for-data-disaggregation-and-operationalization
#6
Adrian Matias Bacong, Christina Holub, Liki Porotesano
Since the 2000 Census, Asians and Pacific Islanders have been categorized as separate races. Government initiatives have called for greater study of Asian, Native Hawaiian, and other Pacific Islander (NHPI) health outcomes. NHPI often have worse health outcomes than Asians and Whites. Despite this, the lack of operationalization of racial definitions may affect the magnitude of health disparities. This analysis examined how utilizing different sociological race definitions could influence NHPI health outcomes when compared to Asians and Whites...
November 2016: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/27920634/frontonasal-dysplasia-towards-an-understanding-of-molecular-and-developmental-aetiology
#7
REVIEW
Peter G Farlie, Naomi L Baker, Patrick Yap, Tiong Y Tan
The complex anatomy of the skull and face arises from the requirement to support multiple sensory and structural functions. During embryonic development, the diverse component elements of the neuro- and viscerocranium must be generated independently and subsequently united in a manner that sustains and promotes the growth of the brain and sensory organs, while achieving a level of structural integrity necessary for the individual to become a free-living organism. While each of these individual craniofacial components is essential, the cranial and facial midline lies at a structural nexus that unites these disparately derived elements, fusing them into a whole...
November 2016: Molecular Syndromology
https://www.readbyqxmd.com/read/27920314/medicaid-meets-its-equal-access-requirement-for-dental-care-but-oral-health-disparities-remain
#8
Jaffer A Shariff, Burton L Edelstein
Most US children today have public or private dental health insurance, yet oral health among publicly insured children remains a policy concern. We analyzed data for 2011-12 from the National Survey of Children's Health to compare oral health status and the use of dental care among publicly and privately insured children. After we adjusted for demographic and parent characteristics, we found no differences between the two groups in parent-reported use of dental care or unmet need for dental care. However, compared to parents of privately insured children, parents of publicly insured children were less likely to report that the condition of their child's teeth was excellent or very good and more likely to report that the child had had a dental problem in the past twelve months...
December 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27920313/previous-medicaid-expansion-may-have-had-lasting-positive-effects-on-oral-health-of-non-hispanic-black-children
#9
Brandy J Lipton, Laura R Wherry, Sarah Miller, Genevieve M Kenney, Sandra Decker
Healthy tooth development starts early in life, beginning even before birth. We present new evidence suggesting that a historic public health insurance expansion for pregnant women and children in the United States in the 1980s and 1990s may have had long-lasting effects on the oral health of the children gaining eligibility. We estimated the relationship between adult oral health and the extent of state public health insurance eligibility for pregnant women, infants, and children throughout childhood separately for non-Hispanic whites, non-Hispanic blacks, and Hispanics...
December 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27920306/underrepresented-minority-dentists-quantifying-their-numbers-and-characterizing-the-communities-they-serve
#10
Elizabeth A Mertz, Cynthia D Wides, Aubri M Kottek, Jean Marie Calvo, Paul E Gates
The underrepresentation of Blacks, Hispanics or Latinos, and American Indians or Alaska Natives among dentists raises concerns about the diversity of the dental workforce, disparities in access to dental care and in oral health status, and social justice. We quantified the shortage of underrepresented minority dentists and examined these dentists' practice patterns in relation to the characteristics of the communities they serve. The underrepresented minority dentist workforce is disproportionately smaller than, and unevenly distributed in relation to, minority populations in the United States...
December 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27920303/the-dental-medical-divide
#11
Elizabeth A Mertz
The importance of oral health for overall well-being cannot be overstated. Yet the US dental delivery system struggles to address effectively the two most common oral diseases (caries and periodontal disease), which are among the most prevalent of all chronic diseases and are largely preventable. This article describes the evolution of contemporary US dental care policy and practice, highlighting the challenges resulting from the dental system's separation from the rest of health care, and explores the implications of this divide for the future of oral health policy and system reform...
December 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27920014/disparities-in-cataract-surgery-volumes-among-ontario-s-ophthalmologists
#12
William Hodge, Efstathia Kiatos
No abstract text is available yet for this article.
December 5, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/27919891/structure-activity-relationships-of-a-series-of-echinocandins-and-the-discovery-of-cd101-a-highly-stable-and-soluble-echinocandin-with-distinctive-pharmacokinetic-properties
#13
Kenneth D James, Christopher P Laudeman, Navdeep B Malkar, Radha Krishnan, Karen Polowy
Echinocandins are first-line therapy for candidemia and invasive candidiasis. They are generally safe with few drug interactions, but the stability and pharmacokinetic properties of currently approved echinocandins are such that each was developed for daily intravenous infusion. We sought to discover a novel echinocandin with properties that would enable more flexible dosing regimens, alternate routes of delivery, and expanded utility. Derivatives of known echinocandin scaffolds were generated, and an iterative process of design and screening led to the discovery of CD101, a novel echinocandin that has since demonstrated improved chemical stability and pharmacokinetics...
December 5, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27919240/urban-rural-differences-in-the-prevalence-of-non-communicable-diseases-risk-factors-among-25-74-years-old-citizens-in-yangon-region-myanmar-a-cross-sectional-study
#14
Aung Soe Htet, Marius B Bjertness, Lhamo Y Sherpa, Marte Karoline Kjøllesdal, Win Myint Oo, Haakon E Meyer, Hein Stigum, Espen Bjertness
BACKGROUND: Recent societal and political reforms in Myanmar may upturn the socio-economy and, thus, contribute to the country's health transition. Baseline data on urban-rural disparities in non-communicable disease (NCD) risk factors are not thoroughly described in this country which has been relatively closed for more than five decades. We aim to investigate urban-rural differences in mean values and the prevalence of selected behavioral and metabolic risk factors for non-communicable diseases and 10-years risk in development of coronary heart diseases (CHD)...
December 5, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27919232/microrna-27a-rs895819-is-associated-with-obesity-in-hiv-infected-preeclamptic-black-south-african-women-on-haart
#15
Niren Ray Maharaj, Prithiksha Ramkaran, Siddharthiya Pillay, Anil Amichund Chuturgoon
BACKGROUND: Preeclampsia (PE) and HIV/AIDS present a major health challenge globally. South Africa has the highest disease burden of both HIV/AIDS and PE in the world. Despite extensive research, the pathophysiology of these conditions is not completely understood, however a genetic predisposition in women may affect susceptibility. MiRNA-27a regulates adipogenesis and glucose metabolism. A single nucleotide polymorphism (SNP) in miRNA-27a (rs895819T > C) has shown to have disparate effects in various populations...
December 5, 2016: BMC Medical Genetics
https://www.readbyqxmd.com/read/27918871/promising-pedagogy-advancing-the-educational-experience-of-queer-students-through-transformative-leadership
#16
Thomas Zook
The school experience for queer youth is often quite different from that of their heterosexual and gender-conforming peers; yet, it is often the case that little attention is given to the disparate and inequitable educational and social conditions under which lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ) youth must learn. In fact, the entirety of pedagogical structures in many schools creates milieus where queer youth, those who have loved ones who are queer, and those who are merely perceived to be queer are systematically marginalized and deprived of their right to a safe, supportive, and equitable educational experience...
December 5, 2016: Journal of Homosexuality
https://www.readbyqxmd.com/read/27918197/educational-inequalities-in-mortality-of-patients-with-atrial-fibrillation-in-norway
#17
Rupali Akerkar, Marta Ebbing, Gerhard Sulo, Inger Ariansen, Jannicke Igland, Grethe S Tell, Grace M Egeland
OBJECTIVES: Socioeconomic gradients provide an indication of mortality's preventable fraction. Given the high mortality associated with atrial fibrillation (AF), we explored the educational gradient in all-cause and cardiovascular mortality in an AF patient population. DESIGN: We prospectively followed patients hospitalized with AF as primary discharge diagnosis. Patients were identified in a nationwide Cardiovascular Disease in Norway 2008-2012 project. The average length of follow-up was 2...
December 5, 2016: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/27918008/diversity-in-the-dermatology-workforce
#18
Jorge A Hinjosa, Amit G Pandya
The United States is becoming increasingly diverse, and minorities are projected to represent the majority of our population in the near future. Unfortunately, health disparities still exist for these groups, and inequalities have also become evident in the field of dermatology. There is currently a lack of diversity within the dermatology workforce. Potential solutions to these health care disparities include increasing cultural competence for all physicians and improving diversity in the dermatology workforce...
December 2016: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27917739/do-cognitive-and-physical-functions-age-in-concert-from-age-70-to-76-evidence-from-the-lothian-birth-cohort-1936
#19
Stuart J Ritchie, Elliot M Tucker-Drob, John M Starr, Ian J Deary
The present study concerns the relation of mental and bodily characteristics to one another during ageing. The 'common cause' theory of ageing proposes that declines are shared across multiple, seemingly-disparate functions, including both physical and intellectual abilities. The concept of 'reserve' suggests that healthier cognitive (and perhaps bodily) functions from early in life are protective against the effects of senescence across multiple domains. In three waves of physical and cognitive testing data from the longitudinal Lothian Birth Cohort 1936 (n = 1,091 at age 70 years; n = 866 at 73; n = 697 at 76), we used multivariate growth curve modeling to test the 'common cause' and 'reserve' hypotheses...
December 5, 2016: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/27917722/racial-disparities-in-papillary-thyroid-microcarcinoma-survival
#20
U C Megwalu, A T Saini
OBJECTIVE: To evaluate the impact of race on survival in patients with papillary thyroid microcarcinoma. METHODS: The study cohort included 17 668 patients diagnosed with papillary thyroid microcarcinoma between 1988 and 2009, identified in the Surveillance, Epidemiology, and End Results 18 database of the National Cancer Institute. RESULTS: Black patients had lower overall survival than other racial groups (p < 0.001). Black patients had significantly worse overall survival (hazard ratio = 2...
December 5, 2016: Journal of Laryngology and Otology
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