keyword
https://read.qxmd.com/read/38458496/tumor-contact-with-internal-mammary-perforator-vessels-as-risk-factor-for-gross-internal-mammary-lymph-node-involvement-in-breast-cancer-patients
#21
JOURNAL ARTICLE
Sophie T Behzadi, Rebecca Moser, Sophia Kiesl, Jana Nano, Jan C Peeken, Julius C Fischer, Eva M Fallenberg, Thomas Huber, Bernhard Haller, Evelyn Klein, Marion Kiechle, Stephanie E Combs, Kai J Borm
IMPORTANCE: The identification of internal mammary lymph node metastases and the assessment of associated risk factors are crucial for adjuvant regional lymph node irradiation in breast cancer patients. The current study aims to investigate if tumor contact with internal mammary perforator vessels is associated with gross internal mammary lymph node involvement. METHODS: We included 297 patients with primary breast cancer and gross internal mammary (IMN+) and/or axillary metastases (AXN+) as well as 230 patients without lymph node metastasis...
March 6, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38457179/incidence-of-nonkeratinocyte-skin-cancer-after-breast-cancer-radiation-therapy
#22
JOURNAL ARTICLE
Shawheen J Rezaei, Edward Eid, Jean Y Tang, Allison W Kurian, Bernice Y Kwong, Eleni Linos
IMPORTANCE: Previous studies have suggested that radiation therapy may contribute to an increased risk of subsequent nonkeratinocyte (ie, not squamous and basal cell) skin cancers. OBJECTIVE: To test the hypothesis that radiation therapy for breast cancer increases the risk of subsequent nonkeratinocyte skin cancers, particularly when these cancers are localized to the skin of the breast or trunk. DESIGN, SETTING, AND PARTICIPANTS: This population-based cohort study used longitudinal data from the Surveillance, Epidemiology, and End Results (SEER) Program for January 1, 2000, to December 31, 2019...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38455634/cytotoxic-activity-of-ethyl-acetate-extract-of-chromolaena-odorata-on-mcf7-and-t47d-breast-cancer-cells
#23
JOURNAL ARTICLE
Hanifah Yusuf, Hijra Novia, Marhami Fahriani
One of the most cancers in women that can be fatal is breast cancer. Radiation therapy, chemotherapy, or a combination of the two are often used to treat cancer, and these treatments tend to modify the immune system and weaken defences. Using natural compounds from plants has become a research interest to prevent cancer cell development. The aim of this study was to determine the anticancer activities of ethyl acetate extract of Chromolaena odorata (EACO) against breast cancer cells (MCF-7 and T47D). The viability of the cells was determined by the MTT colorimetry assays...
December 2023: Narra J
https://read.qxmd.com/read/38455501/brca2-positive-lung-adenocarcinoma-treated-with-olaparib-a-case-report
#24
Takumi Motohashi, Kazutoshi Isobe, Takahiro Yoshizawa, Yusuke Usui, Hiroshige Shimizu, Muneyuki Sekiya, Shion Miyoshi, Yasuhiko Nakamura, Naohisa Urabe, Susumu Sakamoto, Sakae Homma, Sota Sadamoto, Naobumi Tochigi, Kazuma Kishi
A 66-year-old woman was found to have abnormal shadows on a chest radiograph at a previous hospital 4 years ago, which led to a diagnosis of lung adenocarcinoma, cT2aN1M1b stage IVA. First-line treatment included carboplatin and paclitaxel plus thoracic radiotherapy and stereotactic radiation therapy for brain metastases. The patient later underwent second-line pemetrexed treatment, followed by third-line nivolumab, fourth-line docetaxel and bevacizumab, fifth-line tegafur-gimeracil-oteracil, and sixth-line gemcitabine...
March 2024: Respirology Case Reports
https://read.qxmd.com/read/38454124/polygenic-risk-scores-radiation-treatment-exposures-and-subsequent-cancer-risk-in-childhood-cancer-survivors
#25
JOURNAL ARTICLE
Todd M Gibson, Danielle M Karyadi, Stephen W Hartley, Michael A Arnold, Amy Berrington de Gonzalez, Miriam R Conces, Rebecca M Howell, Vidushi Kapoor, Wendy M Leisenring, Joseph P Neglia, Joshua N Sampson, Lucie M Turcotte, Stephen J Chanock, Gregory T Armstrong, Lindsay M Morton
Survivors of childhood cancer are at increased risk for subsequent cancers attributable to the late effects of radiotherapy and other treatment exposures; thus, further understanding of the impact of genetic predisposition on risk is needed. Combining genotype data for 11,220 5-year survivors from the Childhood Cancer Survivor Study and the St Jude Lifetime Cohort, we found that cancer-specific polygenic risk scores (PRSs) derived from general population, genome-wide association study, cancer loci identified survivors of European ancestry at increased risk of subsequent basal cell carcinoma (odds ratio per s...
March 7, 2024: Nature Medicine
https://read.qxmd.com/read/38446215/an-insight-into-thymidylate-synthase-inhibitor-as-anticancer-agents-an-explicative-review
#26
REVIEW
Aratrika Sen, Dipanjan Karati
Cancer, a widespread challenge to global health, remains a puzzle of intricate molecular dynamics. This review article delves into the mystery of cancer, with a keen focus on understanding the contributory role of thymidylate synthase (TS) in cancer. TS, a vital enzyme in DNA synthesis and repair, emerges as a significant player in the narrative of cancer development. The conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) is a major step in producing DNA. Numerous malignancies, including those of the breast, colon, lung, and ovary, have been linked to dysregulation of TS activity...
March 6, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38438408/dynamics-of-a-diffusive-model-for-cancer-stem-cells-with-time-delay-in-microrna-differentiated-cancer-cell-interactions-and-radiotherapy-effects
#27
JOURNAL ARTICLE
Frank Eric Essongo, Alain Mvogo, Germain Hubert Ben-Bolie
Understand the dynamics of cancer stem cells (CSCs), prevent the non-recurrence of cancers and develop therapeutic strategies to destroy both cancer cells and CSCs remain a challenge topic. In this paper, we study both analytically and numerically the dynamics of CSCs under radiotherapy effects. The dynamical model takes into account the diffusion of cells, the de-differentiation (or plasticity) mechanism of differentiated cancer cells (DCs) and the time delay on the interaction between microRNAs molecules (microRNAs) with DCs...
March 4, 2024: Scientific Reports
https://read.qxmd.com/read/38435967/urticaria-heralding-breast-cancer-case-report-and-literature-review
#28
Benjamin Royal-Preyra, Melanie Boucher, Isabelle Marsan
No abstract text is available yet for this article.
April 2024: Advances in Radiation Oncology
https://read.qxmd.com/read/38435966/radiation-therapy-practice-patterns-for-treatment-of-curative-breast-cancer-in-a-large-tertiary-health-care-system
#29
REVIEW
Bhargava Chitti, Dimitre G Stefanov, Louis Potters, Janna Andrews
PURPOSE: Disparities have been reported in women treated for breast cancer (BrCa). This study examines potential disparities in BrCa treatment offered based on race and age from a multicenter radiation department. METHODS AND MATERIALS: We identified 901 patients with early stage BrCa who received curative intent radiation therapy (RT) between 2004 and 2018. Data extracted included age, race, disease stage, treatment technique, treatment dates, and fractionation...
April 2024: Advances in Radiation Oncology
https://read.qxmd.com/read/38435145/clinical-profile-of-triple-negative-breast-cancer-a-hospital-based-study
#30
JOURNAL ARTICLE
Deepak Pankaj, Nitesh Kumar, Anju Singh, Manish Kumar, Zeenat S Imam, Vibhuti Bhushan, Pawan K Jha
Introduction Triple-negative breast cancer (TNBC) is a new concept and an important area of investigation. In Western country's literature, different studies reported on TNBC and all indicated the poor prognostic aspect of this molecular subtype over other types of breast cancer. However, there is a scarcity of comprehensive data from India. Hence, the present study was carried out to look at the epidemiological and clinical characteristics of TNBC in the Indian population. Methods The present study was performed between January 2020 and June 2021 at a tertiary care hospital in Eastern India...
February 2024: Curēus
https://read.qxmd.com/read/38432284/out-of-pocket-cost-modeling-of-adjuvant-antiestrogen-and-radiation-therapy-after-lumpectomy-for-early-stage-breast-cancer-across-medicaid-and-medicare-plans
#31
JOURNAL ARTICLE
Victoria S Wu, Martha Khlopin, Manjeet Chadha, Demetria J Smith-Graziani, Reshma Jagsi, Shearwood McClelland
PURPOSE: The optimal adjuvant therapy (anti-estrogen therapy (ET) + radiotherapy or ET alone, or in some reports radiotherapy alone) in older women with early-stage breast cancer has been highly debated. However, granular details on the role of insurance in the out-of-pocket cost for patients receiving ET with or without radiotherapy are lacking. This project disaggregates out-of-pocket costs by insurance plans to increase treatment cost transparency. METHODS AND MATERIALS: Several radiotherapy schedules are accepted standards as per the National Comprehensive Cancer Network guidelines...
March 1, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38431450/examining-the-impact-of-the-device-used-for-contouring-in-saving-time-and-increasing-the-ease-of-contouring-patients-in-radiotherapy-treatment
#32
JOURNAL ARTICLE
Ebrahim Esmati, Reza Ghalehtaki, Marzieh Lashkari, Mohammad Babaei, Amir Saraee, Hamideh Mortazavi, Ehsan Saraee
INTRODUCTION/BACKGROUND: This study was designed to investigate the amount of time saved and the degree of contour difficulty between the two methods of contouring, mouse/keyboard, versus touch screen/stylus in radiotherapy. METHODS: Each of 94 patients consisting of 26 breast cancer cases, 24 lymph nodes cases, 25 rectal cancer cases, and 19 heart cases has been contoured twice. One with a mouse/keyboard, and the next one with the touch screen/stylus. Three radiation oncologists participated in this study...
March 1, 2024: Journal of Medical Imaging and Radiation Sciences
https://read.qxmd.com/read/38431421/oxidized-cellulose-filled-double-thermo-ph-sensitive-hydrogel-for-local-chemo-photothermal-therapy-in-breast-cancer
#33
JOURNAL ARTICLE
Zijian Zhang, Haoran Cui, Xin Wang, Jie Liu, Guangchun Liu, Xin Meng, Song Lin
Lumpectomy plus radiation is a treatment option offering better survival than conventional mastectomy for patients with early-stage breast cancer. However, successive radioactive therapy remains tedious and unsafe with severe adverse reactions and secondary injury. Herein, a composite hydrogel with pH- and photothermal double-sensitive activity is developed via physical crosslinking. The composite hydrogel incorporated with tempo-oxidized cellulose nanofiber (TOCN), polyvinyl alcohol (PVA) and a polydopamine (PDA) coating for photothermal therapy (PTT) triggered in situ release of doxorubicin (DOX) drug was utilized to optimize postoperative strategies of malignant tumors inhibition...
May 15, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38431232/experience-of-implementing-deep-learning-based-automatic-contouring-in-breast-radiation-therapy-planning-insights-from-over-2-000-cases
#34
JOURNAL ARTICLE
Byung Min Lee, Jin Sung Kim, Yongjin Chang, Seo Hee Choi, Jong Won Park, Hwa Kyung Byun, Yong Bae Kim, Ik Jae Lee, Jee Suk Chang
BACKGROUND AND PURPOSE: This study evaluates the impact and clinical utility of an auto-contouring system for radiation therapy treatments. MATERIALS AND METHODS: The auto-contouring system was implemented in 2019. We evaluated data from 2,428 patients who underwent adjuvant breast radiation therapy before and after the system's introduction. We collected the treatment's finalized contours, reviewed and revised by multidisciplinary team. After implementation, the treatment contours underwent a finalization process which involved manual review and adjustment of the initial auto-contours...
February 29, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38430241/neutrophils-seeking-new-neighbors-radiotherapy-affects-the-cellular-framework-and-the-spatial-organization-in-a-murine-breast-cancer-model
#35
JOURNAL ARTICLE
C M Reichardt, M Muñoz-Becerra, A Rius Rigau, M Rückert, R Fietkau, G Schett, U S Gaipl, B Frey, L E Muñoz
Neutrophils are known to contribute in many aspects of tumor progression and metastasis. The presence of neutrophils or neutrophil-derived mediators in the tumor microenvironment has been associated with poor prognosis in several types of solid tumors. However, the effects of classical cancer treatments such as radiation therapy on neutrophils are poorly understood. Furthermore, the cellular composition and distribution of immune cells in the tumor is of increasing interest in cancer research and new imaging technologies allow to perform more complex spatial analyses within tumor tissues...
March 2, 2024: Cancer Immunology, Immunotherapy: CII
https://read.qxmd.com/read/38429330/acetylcholinesterase-enzyme-among-cancer-patients-a-potential-diagnostic-and-prognostic-indicator-a-multicenter-case-control-study
#36
JOURNAL ARTICLE
Gasmelseed Y Ahmed, Ahmed A Osman, Ahlam Mukhtar
Acetylcholinesterase enzyme (AChE) activity is impaired by a variety of inhibitors including organophosphorus pesticides, leading to the accumulation of acetylcholine. In this study, we aimed to determine the association between cancer and the blood level of the (AChE). This is a multicenter hospital-based case-control study conducted in the Radiation and Isotopes Center Khartoum, and Institute of Nuclear Medicine and Molecular Biology and Oncology Gezira. One hundred and fifty participants, half of them cancer patients and half cancer free were recruited...
March 1, 2024: Scientific Reports
https://read.qxmd.com/read/38428108/omission-of-radiation-therapy-after-breast-conserving-surgery-for-older-women-at-low-risk-of-local-recurrence-one-option-among-many
#37
JOURNAL ARTICLE
Icro Meattini, Ian H Kunkler
This editorial discusses the evolving landscape of early-stage breast cancer treatment, emphasizing the need to tailor therapies based on disease biology and genomic approaches. The focus is on the reconsideration of postoperative radiation therapy (RT) for older patients with low-risk, hormone receptor-positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) breast cancer. Recent trials show modest long-term local recurrence rates with the omission of RT after BCS in certain cases, challenging the traditional approach...
February 23, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38427628/inhaled-anesthesia-associated-with-reduced-mortality-in-patients-with-stage-iii-breast-cancer-a-population-based-study
#38
JOURNAL ARTICLE
Emily Tzu-Jung Kuo, Chin Kuo, Cheng-Li Lin
BACKGROUND: Patients diagnosed with stage III breast cancer often undergo surgery, radiation therapy, and chemotherapy as part of their treatment. The choice of anesthesia technique during surgery has been a subject of interest due to its potential association with immune changes and prognosis. In this study, we aimed to compare the mortality rates between stage III breast cancer patients undergoing surgery with propofol-based intravenous general anesthesia and those receiving inhaled anesthetics...
2024: PloS One
https://read.qxmd.com/read/38427457/correction-to-a-comparative-study-of-boost-dose-delivery-techniques-in-breast-cancer-radiotherapy-optimising-efficacy-and-minimising-toxicity
#39
(no author information available yet)
No abstract text is available yet for this article.
March 1, 2024: Radiation Protection Dosimetry
https://read.qxmd.com/read/38425848/improvement-of-shoulder-motion-in-two-stage-dual-plane-implant-based-breast-reconstruction-followed-by-radiation-therapy-through-delayed-prepectoral-conversion
#40
JOURNAL ARTICLE
Jin Sol Park, Ung Sik Jin
Background  Although prepectoral implant-based breast reconstruction has recently gained popularity, dual-plane reconstruction is still a better option for patients with poor-quality mastectomy skin flaps. However, shoulder morbidity is aggravated by subpectoral reconstruction, especially in irradiated patients. This study aimed to demonstrate shoulder exercise improvement in subpectoral reconstruction by delayed prepectoral conversion with an acellular dermal matrix (ADM) inlay graft technique at the time of expander-to-implant exchange after irradiation...
January 2024: Archives of Plastic Surgery
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