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https://www.readbyqxmd.com/read/29928212/pd-l1-expressing-radiation-associated-angiosarcoma-after-primary-breast-cancer
#1
Kana Takeda, Taku Fujimura, Chunbing Lyu, Akira Tsukada, Kenichiro Tsuchiyama, Akira Hashimoto, Setsuya Aiba
Radiation-associated angiosarcoma (RAAS) is a type of radiation-associated sarcoma (RAS) that develops at the previous field of radiation in breast cancer patients. Although several reports have suggested a poor prognosis for RAAS, the 5-year overall survival of RAAS is better than that of cutaneous angiosarcoma (CAS), suggesting that the prognostic factors of RAAS and CAS might be different, at least in part. In this report, we describe a case of RAAS, and employed immunohistochemical (IHC) staining of PD-L1 and MMP9 as well as periostin, IL-4, and CD163...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29927027/evaluation-of-sparing-organs-at-risk-oars-in-left-breast-irradiation-in-the-supine-and-prone-positions-and-with-deep-inspiration-breath-hold
#2
Amitpal Singh Saini, Catherine S Hwang, Matthew C Biagioli, Indra J Das
PURPOSE: To compare doses to organs at risk (OARs) for left-sided whole-breast radiation therapy with comparable planning target volume (PTV) coverage using three techniques: free breathing in a supine position (SFB), deep inspirational breath-hold in a supine position (SDIBH), and free breathing in prone position (PFB). MATERIALS AND METHODS: Thirty-three patients with left-sided early-stage breast cancer underwent CT simulation following SFB, SDIBH, and PFB protocols for whole-breast radiation therapy...
June 21, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29926793/recommendations-on-prevention-and-screening-for-breast-cancer-in-hong-kong
#3
T H Lam, K H Wong, K Kl Chan, M Cm Chan, D Vk Chao, A Ny Cheung, C Ym Fan, J Ho, E P Hui, K O Lam, C K Law, W L Law, H Hf Loong, R Kc Ngan, T Hf Tsang, M Cs Wong, R Mw Yeung, A Ch Ying, R Ching
In Hong Kong, breast cancer is the most common cancer among women and poses a significant health care burden. The Cancer Expert Working Group on Cancer Prevention and Screening (CEWG) was set up in 2002 by the Cancer Coordinating Committee to review and assess local and international scientific evidence, and to formulate recommendations for cancer prevention and screening. After considering the local epidemiology, emerging scientific evidence, and local and overseas screening practices, the CEWG concluded that it was unclear whether population-based breast cancer screening did more harm than good in local asymptomatic women at average risk...
June 2018: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29924229/prevalence-of-dermatological-complaints-in-patients-undergoing-treatment-for-breast-cancer
#4
Tamara Hoffmann, Mariane Corrêa-Fissmer, Camila Soares Duarte, Rayane Felippe Nazário, Ana Beatriz Sanches Barranco, Karen Waleska Knipoff de Oliveira
BACKGROUND: Internal malignancies such as breast cancer, as well as their treatment can often result in skin changes. OBJECTIVE: To assess the prevalence of dermatological complaints in patients who are undergoing oncological treatment for breast cancer in a hospital in Tubarão, Santa Catarina, Brazil. METHODS: Observational, cross-sectional study, from October 2015 to February 2016 in which 152 patients with the diagnosis of breast cancer, undergoing treatment with chemotherapy, radiotherapy, hormone therapy and/or surgery, were interviewed and completed a research protocol developed by the author...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29923514/whole-body-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-18-f-fdg-pet-ct-for-staging-locally-advanced-breast-cancer-a-prospective-study-from-a-tertiary-cancer-centre-in-south-india
#5
Sivanath Reddy Gajjala, Narendra Hulikal, Silpa Kadiyala, Radhika Kottu, Tekchand Kalawat
Background & objectives: Locally advanced breast cancer (LABC) is associated with substantial risk of occult metastases. The patients with LABC have high rate of systemic relapse, suggesting inadequacy of the current conventional staging in detecting the occult metastatic spread. 18 F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is a new modality in the staging of breast cancer patients. Hence, this study was conducted to evaluate the role of 18 F-FDG PET/CT in initial staging of LABC and to compare it with conventional methods...
March 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29922596/comparison-of-local-recurrence-among-early-breast-cancer-patients-treated-with-electron-intraoperative-radiotherapy-vs-hypofractionated-photon-radiotherapy-an-observational-study
#6
Marina Guenzi, Elisabetta Bonzano, Renzo Corvò, Francesca Merolla, Alice Pastorino, Francesca Cavagnetto, Stefania Garelli, Carlo Alberto Cutolo, Daniele Friedman, Liliana Belgioia
Purpose: To evaluate local recurrence (LR) in women with early breast cancer (BC) who underwent intraoperative radiation therapy with electrons particles (IORT-E) or adjuvant hypofractionated external radiotherapy (HYPOFX). Materials and methods: We retrospectively analyzed 470 patients with early BC treated at our center from September 2009 to December 2012. 235 women were treated with breast-conserving surgery and immediate IORT-E (21 Gy/1 fraction) while 235 patients underwent wide excision followed by hypofractionated whole-breast irradiation...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29921729/integrating-radiosensitivity-and-immune-gene-signatures-for-predicting-benefit-of-radiotherapy-in-breast-cancer
#7
Yi Cui, Bailiang Li, Erqi Liu Pollom, Kathleen Horst, Ruijiang Li
PURPOSE: Breast cancer is a heterogeneous disease and not all patients respond equally to adjuvant radiotherapy. Predictive biomarkers are needed to select patients who will benefit from the treatment and spare others the toxicity and burden of radiation. EXPERIMENTAL DESIGN: We first trained and tested an intrinsic radiosensitivity gene signature to predict local recurrence after radiotherapy in three cohorts of 948 patients. Next, we developed an antigen processing and presentation-based immune signature by maximizing the treatment interaction effect in 129 patients...
June 19, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29917326/replacement-and-desmoplastic-histopathological-growth-patterns-a-pilot-study-of-prediction-of-outcome-in-patients-with-uveal-melanoma-liver-metastases
#8
Raymond Barnhill, Peter Vermeulen, Sofie Daelemans, Pieter-Jan van Dam, Sergio Roman-Roman, Vincent Servois, Ilse Hurbain, Sophie Gardrat, Graça Raposa, Nicolas André, Rémi Dendale, Gaëlle Pierron, Laurence Desjardins, Nathalie Cassoux, Sophie Piperno-Neumann, Pascale Mariani, Claire Lugassy
Up to 50% of uveal melanomas (UM) metastasize to the liver within 10 years of diagnosis, and these almost always prove rapidly fatal. Since histopathological growth patterns (HGP) of liver metastases of the replacement and desmoplastic type, particularly from colon and breast carcinoma, may import valuable biological and prognostic information, we have studied HGP in a series of 41 UM liver metastases originating from 41 patients from the period 2006-2017. Twenty patients underwent enucleation while 21 had radiation therapy...
June 19, 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29914691/adjuvant-radiation-therapy-for-t3n0-breast-cancer-patients-older-than-75-years-after-mastectomy-a-seer-analysis
#9
Jonathan Chen, Xian Wu, Paul Christos, Weisi Yan, Akkamma Ravi
INTRODUCTION: Breast cancer patients with tumors > 5 cm but without nodal disease who undergo mastectomy present a clinical challenge regarding the appropriate adjuvant treatment. Traditionally, postmastectomy radiation therapy (PMRT) was the standard of care. However, recent studies have suggested local failure rates without PMRT might be low enough to omit RT. This might be especially true in the elderly. PATIENTS AND METHODS: Women aged ≥ 75 years with a diagnosis of T3N0 breast cancer who had undergone mastectomy were identified from the Surveillance, Epidemiology, and End Results (SEER) 18 database...
June 15, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29912618/caloric-restriction-counteracts-chemotherapy-induced-inflammation-and-increases-response-to-therapy-in-a-triple-negative-breast-cancer-model
#10
Brittany A Simone, Ajay Palagani, Kimberly Strickland, Kevin Ko, Lianjin Jin, Meng Kieng Lim, Tu D Dan, Mak Sarich, Daniel A Monti, Massimo Cristofanilli, Nicole L Simone
Triple negative breast cancer (TNBC) is a heterogeneous disease that has no available targeted therapies. Previously, we have shown that caloric restriction (CR) can augment the effects of radiation therapy in a TNBC mouse model. To build upon this, we now present data regarding the combination of chemotherapy and CR in the same 4T1 model. Chemotherapy can induce inflammation that breeds resistance to therapy. We propose CR as a mechanism to decrease chemotherapy-induced inflammation and increase efficacy of therapy...
June 18, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29911794/supplementation-with-robuvit%C3%A2-in-post-mastectomy-post-radiation-arm-lymphedema
#11
Gianni Belcaro, Mark Dugall, Roberto Cotellese, Beatrice Feragalli, Ettore Cianchetti, Maria R Cesarone
BACKGROUND: Post-mastectomy lymphedema is one of the most significant, non-life-threatening complications following breast cancer surgery and radiotherapy. Post-mastectomy post-radiotherapy (PMPR) lymphedema is related to damages to lymphatics and/or veins during/after axillary surgery and radiotherapy. The management of this condition is very challenging; the comprehensive decongestive therapy (CTD), which combines physiotherapy, self-management, and hygiene, and is currently considered the standard management (SM)...
June 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29909028/tunable-spr-based-remote-actuation-of-bimetallic-core-shell-nanoparticles-coated-stimuli-responsive-polymer-for-switchable-chemo-photothermal-synergistic-cancer-therapy
#12
Mitra Amoli-Diva, Rasoul Sadighi-Bonabi, Kamyar Pourghazi
New dual light/temperature-responsive nanocarriers were synthesized using bimetallic plasmonic Au-Ag and Ag-Au nanoparticles (NPs) as cores of vehicles which subsequently functionalized with a UCST-based poly acrylamide-co-acrylonitrile using reversible addition-fragmentation chain transfer for spatiotemporally controlled chemo-photothermal synergistic cancer therapy. The bimetallic cores were assigned to sense wavelengths close to the localized SPR of monometallic NP shell to produce heat which not only can increase the surrounding temperature over the UCST of polymer to open the its valves and promote drug diffusion, but also can kill cancerous cells through photothermal effects with increasing in environment temperature nearly 18 °C after about 5 min radiation...
June 14, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29907740/single-breath-hold-photoacoustic-computed-tomography-of-the-breast
#13
Li Lin, Peng Hu, Junhui Shi, Catherine M Appleton, Konstantin Maslov, Lei Li, Ruiying Zhang, Lihong V Wang
We have developed a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to reveal detailed angiographic structures in human breasts. SBH-PACT features a deep penetration depth (4 cm in vivo) with high spatial and temporal resolutions (255 µm in-plane resolution and a 10 Hz 2D frame rate). By scanning the entire breast within a single breath hold (~15 s), a volumetric image can be acquired and subsequently reconstructed utilizing 3D back-projection with negligible breathing-induced motion artifacts...
June 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29907693/exosomes-shuttle-trex1-sensitive-ifn-stimulatory-dsdna-from-irradiated-cancer-cells-to-dendritic-cells
#14
Julie M Diamond, Claire Vanpouille-Box, Sheila Spada, Nils-Petter Rudqvist, Jessica Chapman, Beatrix Ueberheide, Karsten A Pilones, Yasmeen Sarfraz, Silvia C Formenti, Sandra Demaria
Radiotherapy (RT) used at immunogenic doses leads to accumulation of cytosolic double-stranded DNA (dsDNA) in cancer cells, which activates type I IFN (IFN-I) via the cGAS/STING pathway. Cancer cell-derived IFN-I is required to recruit BATF3-dependent dendritic cells (DCs) to poorly immunogenic tumors and trigger antitumor T-cell responses in combination with immune checkpoint blockade. We have previously demonstrated that the exonuclease TREX1 regulates radiation immunogenicity by degrading cytosolic dsDNA...
June 15, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29907505/personalized-automated-treatment-planning-for-breast-plus-locoregional-lymph-nodes-using-hybrid-rapidarc
#15
Mariët J van Duren-Koopman, Jim P Tol, Max Dahele, Ewa Bucko, Philip Meijnen, Ben J Slotman, Wilko F Verbakel
PURPOSE: Breast cancer patients who require locoregional lymph node (LLN) irradiation can be treated using a hybrid RapidArc technique combining 2 tangential and 3 RapidArc fields. Because the creation of hybrid RapidArc plans is complex and labor-intensive, we developed an automated treatment planning workflow using the scripting application programming interface of the Eclipse treatment planning system. METHODS AND MATERIALS: Fifteen patients (5 right- and 10 left-sided) previously treated with breast + LLN radiation therapy were replanned using the script...
March 26, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29904942/inhibition-of-notch-signaling-pathway-enhanced-the-radiosensitivity-of-breast-cancer-cells
#16
Jian-Heng Peng, Xiao-Lin Wang, Liang Ran, Jun-Long Song, Zhi-Ting Zhang, Xin Liu, Hong-Yuan Li
This study aimed to investigate the effect of inhibiting the Notch signaling pathway on the radiosensitivity of breast cancer cells. Human breast cancer cell lines (MCF-7 and T47D) were selected and treated with radiation of different doses. Cells were treated with Gamma secretase inhibitor (GSI) to analyze the effects of GSI on the Notch signaling, which were detected by Immunofluorescence assay, RT-qPCR, and Western blot analysis. Besides, Transwell assay, Scratch test, colony formation assay, MTT assay, and flow cytometry were conducted to show the effects of GSI on the invasion and migration, survival fraction, cell viability, and apoptosis of MCF-7 and T47D cells after radiation therapy...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29904731/the-pervasive-crisis-of-diminishing-radiation-therapy-access-for-vulnerable-populations-in-the-united-states-part-3-hispanic-american-patients
#17
Shearwood McClelland, Carmen A Perez
Purpose: Health disparities have profoundly affected underrepresented minorities throughout the United States, particularly with regard to access to evidence-based interventions such as surgery or medication. The degree of disparity in access to radiation therapy (RT) for Hispanic-American patients with cancer has not been previously examined in an extensive manner. Methods and materials: An extensive literature search was performed using the PubMed database to examine studies investigating disparities in RT access for Hispanic-Americans...
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29903550/radiotherapy-utilization-and-fractionation-patterns-during-the-first-course-of-cancer-treatment-in-the-united-states-from-2004-to-2014
#18
Trevor J Royce, Muhammad M Qureshi, Minh Tam Truong
BACKGROUND: The changing use of radiation as a first-line cancer therapy in the United States is poorly characterized. This study aims to report radiotherapy utilization and fractionation patterns during the first course of cancer treatment. METHODS: We extracted all solid tumor cases from 2004 to 2014 in the National Cancer Data Base, which captures only the first course of treatment. Patients were subcategorized by disease site: breast, central nervous system (CNS), gastrointestinal, genitourinary, gynecologic, head and neck (HN), musculoskeletal, skin, or thoracic...
June 11, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29902386/hypofractionated-radiation-treatment-in-the-management-of-breast-cancer
#19
Apar Gupta, Nisha Ohri, Bruce G Haffty
The standard treatment for early-stage breast cancer is breast conservation therapy, consisting of breast conserving surgery followed by adjuvant radiation treatment (RT). Conventionally-fractionated whole breast irradiation (CF-WBI) has been the standard RT regimen, but recently shorter courses of hypofractionated whole breast irradiation (HF-WBI) have been advocated for patient convenience and reduction in healthcare costs and resources. Areas covered: This review covers the major randomized European and Canadian trials comparing HF-WBI to CF-WBI with long-term follow-up, as well as additional recently closed randomized trials that further seek to define the applicability of HF-WBI in clinical practice...
June 14, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29897976/the-impact-of-dependent-coverage-expansion-under-the-affordable-care-act-on-time-to-breast-cancer-treatment-among-young-women
#20
Xuesong Han, Jingxuan Zhao, Kathryn J Ruddy, Chun Chieh Lin, Helmneh M Sineshaw, Ahmedin Jemal
INTRODUCTION: Breast cancer in young women tends to be more aggressive, but timely treatment may not be always available, particularly to those without health insurance. We aim to examine whether the dependent coverage expansion under the Affordable Care Act (ACA-DCE) implemented in 2010 was associated with changes in time to treatment among women diagnosed with early stage breast cancer. METHODS: A total of 7,176 patients diagnosed with early stage breast cancer in 2007-2009 (pre-ACA) and 2011-2013 (post-ACA) were identified from the National Cancer Database...
2018: PloS One
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