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Breast cancer radiation

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https://www.readbyqxmd.com/read/29221676/prospective-medical-analysis-of-radiation-therapist-image-repositioning-during-image-guided-radiotherapy
#1
O Lauche, F Castan, H de Forges, C Guillaumon, S Gourgou, P Fenoglietto, N Aillères, D Azria, O Riou
PURPOSE: Radiation oncologists are responsible for deciding which day-to-day variations are acceptable or not in the treatment setup. However, properly qualified and trained radiation therapists might be capable to perform image registration. We evaluated in our centre the capability and accuracy of radiation therapists to validate positioning images in a prospective study. METHODS AND PATIENTS: A total of 84 patients treated for prostate, head and neck, lung or breast cancer was prospectively and randomly included from July 2011 to July 2013 in radiotherapy unit of our institution...
December 5, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29218614/18f-fluorodeoxyglucose-specimen-positron-emission-mammography-delineates-tumour-extension-in-breast-conserving-surgery-preliminary-results
#2
Gou Watanabe, M Itoh, X Duan, H Watabe, N Mori, H Tada, A Suzuki, M Miyashita, N Ohuchi, T Ishida
OBJECTIVES: We aimed to determine whether high-resolution specimen-positron emission mammography (PEM) using fluorodeoxyglucose (18F-FDG) can reveal extension of breast cancer in breast-conserving surgery (BCS), and assess the safety of radiation exposure to medical staff. METHODS: Sixteen patients underwent positron emission tomography, and then BCS with intraoperative frozen section analysis on the same day. Resected specimens with remaining 18F-FDG accumulation were scanned by high-resolution PEM...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29208514/fragmentation-level-determines-mitochondrial-damage-response-and-subsequently-the-fate-of-cancer-cells-exposed-to-carbon-ions
#3
Xiaodong Jin, Xiaogang Zheng, Feifei Li, Bingtao Liu, Hongbin Li, Ryoichi Hirayama, Ping Li, Xiongxiong Liu, Guosheng Shen, Qiang Li
OBJECTIVES: Although mitochondria are known to play an important role in radiation-induced cellular damage response, the mechanisms of how radiation elicits mitochondrial responses are largely unknown. MATERIALS AND METHODS: Human cervical cancer cell line HeLa and human breast cancer cell lines MCF-7 and MDA-MB-231 were irradiated with high LET carbon ions at low (0.5 Gy) and high (3 Gy) doses. Mitochondrial functions, dynamics, mitophagy, intrinsic apoptosis and total apoptosis, and survival fraction were investigated after irradiation...
December 2, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29208461/simvastatin-inhibits-the-development-of-radioresistant-esophageal-cancer-cells-by-increasing-the-radiosensitivity-and-reversing-emt-process-via-the-pten-pi3k-akt-pathway
#4
Yingying Jin, Kun Xu, Qingjuan Chen, Baofeng Wang, Jiyuan Pan, Shan Huang, Yang Wei, Hongbing Ma
Acquired radioresistance compromises the efficacy of radiotherapy for carcinomas including esophageal cancer (EC), thus resulting in recurrence and poor survival. Recent research corroborated radiosensitive function of simvastatin in stem-like breast cancer cells. However, its role in EC radioresistance remains poorly elucidated. Here, we developed a radioresistant EC cell line Ec9706-R with higher resistance to irradiation relative to control Ec9706 cells. Intriguingly, Ec9706-R cells exhibited epithelial-mesenchymal transition (EMT) characteristics with high invasion and migration ability...
December 2, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29207864/long-term-cosmesis-following-a-novel-schedule-of-accelerated-partial-breast-radiation-in-selected-early-stage-breast-cancer-result-of-a-prospective-clinical-trial
#5
Mutlay Sayan, Daphne Hard, Karen Wilson, Carl Nelson, Havaleh Gagne, Deborah Rubin, Ruth Heimann
Purpose: There is controversy regarding the cosmetic outcome after accelerated partial breast radiation (APBR). We report the cosmetic outcome from a single-arm prospective clinical trial of APBR delivered using intensity-modulated radiation therapy (IMRT) in elderly patients with stage I breast cancer (BC), using a novel fractionation schedule. Materials and Methods: Forty-two patients aged ≥65, with Stage I BC who underwent breast-conserving surgery were enrolled in a phase I/II study evaluating a 2-week course of APBR...
December 15, 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29206598/is-there-unmeasured-indication-bias-in-radiation-related-cancer-risk-estimates-from-studies-of-computed-tomography
#6
Johanna M Meulepas, Michael Hauptmann, Jay H Lubin, Igor Shuryak, David J Brenner
Recently reported studies have associated radiation exposure from computed tomography (CT) scanning with small excess cancer risks. However, since existing medical records were used in these studies, they could not control for reasons for the CT scans and therefore, the results may have been confounded by indication. Here we conducted a study to estimate potential indication bias that could affect hazard ratios for colorectal, lung and female breast cancers by reasons for a CT scan. This involved a retrospective cohort study of electronic records from all patients aged 18-89 years without previous cancer diagnoses, who received at least one CT scan at Columbia University Medical Center in the period of 1994-2014...
December 5, 2017: Radiation Research
https://www.readbyqxmd.com/read/29205355/clinical-outcomes-in-breast-angiosarcoma-patients-a-rare-tumor-with-unique-challenges
#7
Mai-Kim Gervais, Sally M Burtenshaw, Jessica Maxwell, Brendan C Dickson, Charles N Catton, Martin Blackstein, David McCready, Jaime Escallon, Rebecca A Gladdy
BACKGROUND: Breast angiosarcoma (AS) accounts for less than 1% of all breast cancers. The goal of this study was to determine patient outcomes in radiation-associated angiosarcoma of the breast (RAAS) and sporadic AS. We evaluated patterns of recurrence and predictors of breast AS survival. METHODS: Patients with pathologically confirmed AS from 1994 to 2014 referred to Mount Sinai Hospital/Princess Margaret Cancer Centre were included. Primary outcome was overall survival (OS)...
December 4, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29205077/forty-years-of-landmark-trials-undertaken-by-the-danish-breast-cancer-cooperative-group-dbcg-nationwide-or-in-international-collaboration
#8
Bent Ejlertsen, Birgitte Vrou Offersen, Jens Overgaard, Peer Christiansen, Maj-Britt Jensen, Niels Kroman, Ann Søgaard Knoop, Henning Mouridsen
BACKGROUND: Over the past 40 years the Danish Breast Cancer Cooperative Group (DBCG) has made significant contributions to improve outcome and to make treatment of patients with early breast cancer more tolerable through nationwide and international trials evaluating loco-regional and systemic treatments. These trials have been instrumental to establish standards for the treatment of early breast cancer. METHODS: The DBCG 82 trials had a global impact by documenting that the significant gain in loco-regional recurrence from postmastectomy radiation added to systemic therapy was associated with a reduction in distant recurrence and mortality in high-risk pre- and postmenopausal patients...
December 5, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29204519/cardiac-sparing-radiation-therapy-using-positioning-breast-shell-for-patients-with-left-sided-breast-cancer-who-are-ineligible-for-breath-hold-techniques
#9
Kurian Joseph, Heather Warkentin, Sunita Ghosh, Lee-Anne Polkosnik, Kent Powell, Matthew Brennan, Brad Warkentin, Johanna Jacobs, Khalifa Alkaabi, Susan Chafe, Keith Tankel, Zsolt Gabos, Hong-Wei Liu, Patricia Tai
Purpose: Patients with left-sided breast cancer (LSBC) are at increased risk of cardiac morbidity from adjuvant breast radiation therapy (ABRT). Breath-hold (BH) techniques substantially reduce the radiation received by heart during radiation therapy for LSBC. However, a subset of patients with LSBC are ineligible for BH techniques due to an inability to breath-hold or because of other comorbidities. To reduce radiation to the heart, we routinely use a custom-made breast shell for the treatment of patients with LSBC who are ineligible for BH techniques...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29204518/the-pervasive-crisis-of-diminishing-radiation-therapy-access-for-vulnerable-populations-in-the-united-states-part-1-african-american-patients
#10
Shearwood McClelland, Brandi R Page, Jerry J Jaboin, Christina H Chapman, Curtiland Deville, Charles R Thomas
Introduction: African Americans experience the highest burden of cancer incidence and mortality in the United States and have been persistently less likely to receive interventional care, even when such care has been proven superior to conservative management by randomized controlled trials. The presence of disparities in access to radiation therapy (RT) for African American cancer patients has rarely been examined in an expansive fashion. Methods and materials: An extensive literature search was performed using the PubMed database to examine studies investigating disparities in RT access for African Americans...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29202657/a-case-of-gastric-cancer-metastasis-to-the-breast-in-a-female-with-brca2-germline-mutation-and-literature-review
#11
Audrius Dulskas, Mahdi Al Bandar, Yoon Young Choi, Su-Jin Shin, Seung-Hoon Beom, Taeil Son, Hyung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh
INTRODUCTION: Gastric cancer is a deadly disease. Common sites of distant metastasis of gastric cancer are the peritoneum, liver, lymph nodes, and lung. The breast is a rare site of metastasis in gastric cancer which occurs in males dominantly. PATIENTS AND METHODS: Here, we report the first case of metastatic gastric cancer to the breast in a patient with the breast cancer 2 (BRCA2) germline mutation. A 34-year-old female was admitted to the hospital with dyspepsia and a palpable mass in the left breast...
December 5, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29200112/epidemiology-treatment-and-complications-of-central-nervous-system-metastases
#12
Amy A Pruitt
PURPOSE OF REVIEW: Neurologic problems resulting from systemic cancer metastases to brain parenchyma, dura, spinal cord, and leptomeninges are among the most common types of consultations addressed by neurologists. With patients surviving longer from systemic cancer, along with the rapidly evolving therapeutic options, the treatment of these devastating complications has become both more effective and more complicated. This article reviews current patterns of metastatic disease and the increasingly nuanced landscape of evolving therapies, their complications, and their impact on quality of survival...
December 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29197746/proton-therapy-for-locally-advanced-breast-cancer-a-systematic-review-of-the-literature
#13
REVIEW
Emmanuel Kammerer, Jennifer Le Guevelou, Abdulhamid Chaikh, Serge Danhier, Julien Geffrelot, Christelle Levy, Eric Saloux, Jean-Louis Habrand, Juliette Thariat
BACKGROUND: Radiation therapy plays a major role in the management of adjuvant breast cancer with nodal involvement, with an iatrogenic increase of cardio-vascular risk. Photon therapy, even with intensity modulation, has the downsides of high mean heart dose and heterogeneous target coverage, particularly in the case of internal mammary irradiation. This systematic review of the literature aims to evaluate proton therapy in locally advanced breast cancer. MATERIAL AND METHODS: PubMed was searched for original full-text articles with the following search terms: «Proton Therapy» and «Breast Cancer»...
November 24, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29195057/novel-radiotherapy-techniques-for-breast-cancer
#14
Julie A Bradley, Nancy P Mendenhall
During the early decades of radiation therapy for breast cancer, local control of disease was documented consistently but, enigmatically, an anticipated impact on breast cancer survival was not observed, leading to confusion in our understanding of the natural history of breast cancer and radiation effects. Now, almost 90 years after its first use in breast cancer, technology developments in diagnostic imaging and radiation therapy have elucidated parts of this enigma. The data now available demonstrate a significant impact of radiation therapy on survival as well as disease control and treatment-related mortality, opening a doorway to understanding the powerful impact of radiation therapy on both breast cancer and critical organs...
December 1, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/29193395/androgen-and-oestrogen-receptors-as-potential-prognostic-markers-for-patients-with-ductal-carcinoma-in%C3%A2-situ-treated-with-surgery-and-radiotherapy
#15
Sara Ravaioli, Maria Maddalena Tumedei, Flavia Foca, Roberta Maltoni, Andrea Rocca, Ilaria Massa, Elisabetta Pietri, Sara Bravaccini
Ductal carcinoma in situ (DCIS) is a heterogeneous disease that has been investigated less extensively than invasive breast cancer. Women with DCIS are mainly treated with conservative surgery almost exclusively followed by radiotherapy. However, as radiation treatment is not always effective, the search for biomarkers capable of identifying DCIS lesions that could progress to invasive cancer is ongoing. Although conventional biomarkers have been thoroughly studied in invasive tumours, little is known about the role played by androgen receptor (AR), widely expressed in DCIS...
November 28, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29192329/oral-curcumin-for-radiation-dermatitis-a-urcc-ncorp-study-of-686-breast-cancer-patients
#16
Julie Ryan Wolf, Charles E Heckler, Joseph J Guido, Anita R Peoples, Jennifer S Gewandter, Marilyn Ling, Vincent P Vinciguerra, Thomas Anderson, Lisa Evans, James Wade, Alice P Pentland, Gary R Morrow
PURPOSE: Despite advances in medical technology, radiation dermatitis occurs in 95% of patients receiving radiation therapy (RT) for cancer. Currently, there is no standard and effective treatment for the prevention or control of radiation dermatitis. The goal of the study was to determine the efficacy of oral curcumin, one of the biologically active components in turmeric, at reducing radiation dermatitis severity (RDS) at the end of RT, using the RDS scale, compared to placebo. METHODS: This was a multisite, randomized, double-blinded, placebo-controlled trial of 686 breast cancer patients...
December 1, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29188405/promoting-effects-of-adipose-derived-stem-cells-on-breast-cancer-cells-are-reversed-by-radiation-therapy
#17
Annemarie Baaße, Dajana Juerß, Elaine Reape, Katrin Manda, Guido Hildebrandt
Partial breast irradiation of early breast cancer patients after lumpectomy and the use of endogenous adipose tissue (AT) for breast reconstruction are promising applications to reduce the side effects of breast cancer therapy. This study tries to investigate the possible risks associated with these therapeutic approaches. It also examines the influence of adipose derived stem cells (ADSCs) as part of the breast cancer microenvironment, and endogenous AT on breast cancer cells following radiation therapy. ADSCs, isolated from human reduction mammoplasties of healthy female donors, exhibited multilineage capacity and specific surface markers...
November 29, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29188166/tractography-for-optic-radiation-preservation-in-transcortical-approaches-to-intracerebral-lesions
#18
Vijay Agarwal, James G Malcolm, Gustavo Pradilla, Daniel L Barrow
We present a case of intraventricular meningioma resected via a transcortical approach using tractography for optic radiation and arcuate fasciculus preservation. We include a review of the literature. A 54-year-old woman with a history of breast cancer presented with gait imbalance. Workup revealed a mass in the atrium of the left lateral ventricle consistent with a meningioma. Whole brain automated diffusion tensor imaging (DTI) was used to plan a transcortical resection while sparing the optic radiations and arcuate fasciculus...
September 28, 2017: Curēus
https://www.readbyqxmd.com/read/29187880/the-parp-1-inhibitor-olaparib-suppresses-brca1-protein-levels-increases-apoptosis-and-causes-radiation-hypersensitivity-in-brca1-lymphoblastoid-cells
#19
Emma C Bourton, Pia-Amata Ahorner, Piers N Plowman, Sheba Adam Zahir, Hussein Al-Ali, Christopher N Parris
The use of polyADPribose polymerase inhibitors in cancer treatment provides a unique opportunity to target DNA repair processes in cancer cells while leaving normal tissue intact. The PARP-1 enzyme repairs DNA single strand breaks (SSB). Therefore PARP-1 inhibition in BRCA1 negative cancers results in the formation of cytotoxic DNA double strand breaks (DSB) causing synthetic lethality. The use of PARP1 inhibitors is gaining momentum in the treatment of a variety of tumours with BRCA1 involvement including breast, ovarian, pancreatic and prostate cancer...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29180477/mir-139-5p-modulates-radiotherapy-resistance-in-breast-cancer-by-repressing-multiple-gene-networks-of-dna-repair-and-ros-defense
#20
Marina Pajic, Danielle Froio, Sheridan Daly, Louise Doculara, Ewan Millar, Peter H Graham, Alison Drury, Angela Steinmann, Charles E de Bock, Alice Boulghourjian, Anaiis Zaratzian, Susan Carroll, Joanne Toohey, Sandra A O'Toole, Adrian L Harris, Francesca M Buffa, Harriet E Gee, Georgina E Hollway, Timothy J Molloy
Radiotherapy (RT) is essential to the treatment of most solid tumors and acquired or innate resistance to this therapeutic modality is a major clinical problem. Here we show that miR-139-5p is a potent modulator of radiotherapy response in breast cancer (BC) via its regulation of genes involved in multiple DNA repair and reactive oxygen species defense pathways. Treatment of breast cancer cells with a miR-139-5p mimic strongly synergized with radiation both in vitro and in vivo, resulting in significantly increased oxidative stress, accumulation of unrepaired DNA damage and induction of apoptosis...
November 27, 2017: Cancer Research
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