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https://www.readbyqxmd.com/read/23609449/structure-of-the-lectin-mannose-6-phosphate-receptor-homology-mrh-domain-of-glucosidase-ii-an-enzyme-that-regulates-glycoprotein-folding-quality-control-in-the-endoplasmic-reticulum
#1
Linda J Olson, Ramiro Orsi, Solana G Alculumbre, Francis C Peterson, Ivan D Stigliano, Armando J Parodi, Cecilia D'Alessio, Nancy M Dahms
Here we report for the first time the three-dimensional structure of a mannose 6-phosphate receptor homology (MRH) domain present in a protein with enzymatic activity, glucosidase II (GII). GII is involved in glycoprotein folding in the endoplasmic reticulum. GII removes the two innermost glucose residues from the Glc3Man9GlcNAc2 transferred to nascent proteins and the glucose added by UDP-Glc:glycoprotein glucosyltransferase. GII is composed of a catalytic GIIα subunit and a regulatory GIIβ subunit. GIIβ participates in the endoplasmic reticulum localization of GIIα and mediates in vivo enhancement of N-glycan trimming by GII through its C-terminal MRH domain...
June 7, 2013: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/21441784/coverage-and-predictors-of-influenza-vaccine-uptake-among-adults-aged-16-to-59-years-suffering-from-a-chronic-condition-in-madrid-spain
#2
Cristina Rodríguez-Rieiro, Maria Felicitas Domínguez-Berjón, María D Esteban-Vasallodomínguez-Berjón, Agustin Rivero Cuadrado, Pilar Carrasco-Garrido, Rodrigo Jiménez-García
Based on data drawn from the 2007 Madrid Regional Health Survey (MRHS), we sought to: estimate influenza vaccination coverage among people ages 16-59 years old suffering from chronic conditions (cardiovascular diseases, diabetes, respiratory diseases, kidney diseases, malignant neoplasm and fibromyalgia) living in the region of Madrid and to determine which socio-demographic and health-related variables were associated with the likelihood of being vaccinated. We analyzed data from 8,337 subjects. The reply to the question "Were you vaccinated against influenza in the last vaccination campaign?" was taken as the dependent variable...
May 2011: Human Vaccines
https://www.readbyqxmd.com/read/19282545/mixed-reality-humans-evaluating-behavior-usability-and-acceptability
#3
Aaron Kotranza, Benjamin Lok, Adeline Deladisma, Carla M Pugh, D Scott Lind
This paper presents Mixed Reality Humans (MRHs), a new type of embodied agent enabling touch-driven communication. Affording touch between human and agent allows MRHs to simulate interpersonal scenarios in which touch is crucial. Two studies provide initial evaluation of user behavior with a MRH patient and the usability and acceptability of a MRH patient for practice and evaluation of medical students' clinical skills. In Study I (n=8) it was observed that students treated MRHs as social actors more than students in prior interactions with virtual human patients (n=27), and used interpersonal touch to comfort and reassure the MRH patient similarly to prior interactions with human patients (n=76)...
May 2009: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/15234918/rural-interprofessional-service-learning-the-minnesota-experience
#4
Daniel G Mareck, Donald L Uden, Tom A Larson, Melanie F Shepard, Roger J Reinert
The Minnesota Rural Health School (MRHS), which operated from 1996 to 2003, was the University of Minnesota's first initiative that provided rural, community-based, interdisciplinary health professions education. The newly funded Minnesota Area Health Education Center (AHEC) is now coordinating interprofessional rural clinical education at the Academic Health Center level for the university. The service-learning curricular component is one of the most lasting legacies of the MRHS. This article provides a descriptive summary of the initial 61 service-learning projects completed by students from various health professions who participated in the MRHS and indicates the type of projects that have continuing effects...
July 2004: Academic Medicine: Journal of the Association of American Medical Colleges
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