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https://www.readbyqxmd.com/read/28107625/gold-nanoshell-mediated-remote-myotube-activation
#1
Attilio Marino, Satoshi Arai, Yanyan Hou, Andrea Degl'Innocenti, Valentina Cappello, Barbara Mazzolai, Young-Tae Chang, Virgilio Mattoli, Madoka Suzuki, Gianni Ciofani
Mild heat stimulation of muscle cells within the physiological range represents an intriguing approach for the modulation of their functions. In this work, photothermal conversion was exploited to remotely stimulate striated muscle cells by using gold nanoshells (NS) in combination with near-infrared (NIR) radiation. Temperature increments of approximately 5°C were recorded by using an intracellular fluorescent molecular thermometer and were demonstrated to efficiently induce myotube contraction. The mechanism at the base of this phenomenon was thoroughly investigated and was observed to be a Ca2+-independent event directly involving actin-myosin interactions...
January 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28105954/the-amp-foot-3-new-generation-propulsive-prosthetic-feet-with-explosive-motion-characteristics-design-and-validation
#2
Pierre Cherelle, Victor Grosu, Manuel Cestari, Bram Vanderborght, Dirk Lefeber
The last decades, rehabilitation has become a challenging context for mechatronical engineering. From the state-of-the-art it is seen that the field of prosthetics offers very promising perspectives to roboticist. Today's prosthetic feet tend to improve amputee walking experience by delivering the necessary push-off forces while walking. Therefore, several new types of (compliant) actuators are developed in order to fulfill the torque and power requirements of a sound ankle-foot complex with minimized power consumption...
December 19, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28104408/adding-simultaneous-stimulating-channels-to-reduce-power-consumption-in-cochlear-implants
#3
Florian Langner, Aniket Saoji, Andreas Büchner, Waldo Nogueira
Sound coding strategies for Cochlear Implant (CI) listeners can be used to control the trade-off between speech performance and power consumption. Most commercial CI strategies use non-simultaneous channel stimulation, stimulating only one electrode at a time. One could add parallel simultaneous stimulating channels such that the electrical interaction between channels is increased. This would produce spectral smearing, because the electrical fields of the simultaneous stimulated channels interact, but also power savings...
January 16, 2017: Hearing Research
https://www.readbyqxmd.com/read/28093018/algorithm-for-bionic-hand-reconstruction-in-patients-with-global-brachial-plexopathies
#4
Laura A Hruby, Agnes Sturma, Johannes A Mayer, Anna Pittermann, Stefan Salminger, Oskar C Aszmann
OBJECTIVE Global brachial plexus lesions with multiple root avulsions are among the most severe nerve injuries, leading to lifelong disability. Fortunately, in most cases primary and secondary reconstructions provide a stable shoulder and restore sufficient arm function. Restoration of biological hand function, however, remains a reconstructive goal that is difficult to reach. The recently introduced concept of bionic reconstruction overcomes biological limitations of classic reconstructive surgery to restore hand function by combining selective nerve and muscle transfers with elective amputation of the functionless hand and its replacement with a prosthetic device...
January 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28053309/drag-reduction-through-self-texturing-compliant-bionic-materials
#5
Eryong Liu, Longyang Li, Gang Wang, Zhixiang Zeng, Wenjie Zhao, Qunji Xue
Compliant fish skin is effectively in reducing drag, thus the design and application of compliant bionic materials may be a good choice for drag reduction. Here we consider the drag reduction of compliant bionic materials. First, ZnO and PDMS mesh modified with n-octadecane were prepared, the drag reduction of self-texturing compliant n-octadecane were studied. The results show that the mesh modified by ZnO and PDMS possess excellent lipophilic and hydrophobic, thus n-octadecane at solid, semisolid and liquid state all have good adhesion with modified mesh...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28045836/effects-of-stimulus-polarity-and-artifact-reduction-method-on-the-electrically-evoked-compound-action-potential
#6
Michelle L Hughes, Jenny L Goehring, Jacquelyn L Baudhuin
OBJECTIVE: Previous research from our laboratory comparing electrically evoked compound action potential (ECAP) artifact reduction methods has shown larger amplitudes and lower thresholds with cathodic-leading forward masking (CathFM) than with alternating polarity (AltPol). One interpretation of this result is that the anodic-leading phase used with AltPol elicits a less excitatory response (in contrast to results from recent studies with humans), which when averaged with responses to cathodic-leading stimuli, results in smaller amplitudes...
December 30, 2016: Ear and Hearing
https://www.readbyqxmd.com/read/28018834/detailed-measurement-of-wall-strain-with-3d-speckle-tracking-in-the-aortic-root-a-case-of-bionic-support-for-clinical-decision-making
#7
Sebastian Vogt, Konstantinos Karatolios, Andreas Wittek, Christopher Blasé, Anette Ramaswamy, Nikolas Mirow, Rainer Moosdorf
Three-dimensional (3D) wall motion tracking (WMT) based on ultrasound imaging enables estimation of aortic wall motion and deformation. It provides insights into changes in vascular compliance and vessel wall properties essential for understanding the pathogenesis and progression of aortic diseases. In this report, we employed the novel 3D WMT analysis on the ascending aorta aneurysm (AA) to estimate local aortic wall motion and strain in case of a patient scheduled for replacement of the aortic root. Although progression of the diameter indicates surgical therapy, at present we addressed the question for optimal surgical time point...
December 2016: Thoracic and Cardiovascular Surgeon Reports
https://www.readbyqxmd.com/read/28017556/bilateral-globus-pallidus-internus-deep-brain-stimulation-for-dyskinetic-cerebral-palsy-supports-success-of-cochlear-implantation-in-a-5-year-old-ex-24%C3%A2-week-preterm-twin-with-absent-cerebellar-hemispheres
#8
Jean-Pierre Lin, Margaret Kaminska, Sarah Perides, Hortensia Gimeno, Lesley Baker, Daniel E Lumsden, Anzell Britz, Sandra Driver, Alec Fitzgerald-O'Connor, Richard Selway
BACKGROUND: Early onset dystonia (dyskinesia) and deafness in childhood pose significant challenges for children and carers and are the cause of multiple disability. It is particularly tragic when the child cannot make use of early cochlear implantation (CI) technology to relieve deafness and improve language and communication, because severe cervical and truncal dystonia brushes off the magnetic amplifier behind the ears. Bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) neuromodulation can reduce dyskinesia, thus supporting CI neuromodulation success...
December 10, 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28007348/home-use-of-a-bihormonal-bionic-pancreas-versus-insulin-pump-therapy-in-adults-with-type-1-diabetes-a-multicentre-randomised-crossover-trial
#9
Firas H El-Khatib, Courtney Balliro, Mallory A Hillard, Kendra L Magyar, Laya Ekhlaspour, Manasi Sinha, Debbie Mondesir, Aryan Esmaeili, Celia Hartigan, Michael J Thompson, Samir Malkani, J Paul Lock, David M Harlan, Paula Clinton, Eliana Frank, Darrell M Wilson, Daniel DeSalvo, Lisa Norlander, Trang Ly, Bruce A Buckingham, Jamie Diner, Milana Dezube, Laura A Young, April Goley, M Sue Kirkman, John B Buse, Hui Zheng, Rajendranath R Selagamsetty, Edward R Damiano, Steven J Russell
BACKGROUND: The safety and effectiveness of a continuous, day-and-night automated glycaemic control system using insulin and glucagon has not been shown in a free-living, home-use setting. We aimed to assess whether bihormonal bionic pancreas initialised only with body mass can safely reduce mean glycaemia and hypoglycaemia in adults with type 1 diabetes who were living at home and participating in their normal daily routines without restrictions on diet or physical activity. METHODS: We did a random-order crossover study in volunteers at least 18 years old who had type 1 diabetes and lived within a 30 min drive of four sites in the USA...
December 20, 2016: Lancet
https://www.readbyqxmd.com/read/27992321/robo-psychophysics-extracting-behaviorally-relevant-features-from-the-output-of-sensors-on-a-prosthetic-finger
#10
Benoit P Delhaye, Erik W Schluter, Sliman J Bensmaia
Efforts are underway to restore sensorimotor function in amputees and tetraplegic patients using anthropomorphic robotic hands. For this approach to be clinically viable, sensory signals from the hand must be relayed back to the patient. To convey tactile feedback necessary for object manipulation, behaviorally relevant information must be extracted in real time from the output of sensors on the prosthesis. In the present study, we recorded the sensor output from a state-of-the-art bionic finger during the presentation of different tactile stimuli, including punctate indentations and scanned textures...
October 2016: IEEE Transactions on Haptics
https://www.readbyqxmd.com/read/27981005/human-like-sensing-and-reflexes-of-graphene-based-films
#11
Qin Zhang, Lifang Tan, Yunxu Chen, Tao Zhang, Wenjie Wang, Zhongfan Liu, Lei Fu
Humans have numerous senses, wherein vision, hearing, smell, taste, and touch are considered as the five conventionally acknowledged senses. Triggered by light, sound, or other physical stimulations, the sensory organs of human body are excited, leading to the transformation of the afferent energy into neural activity. Also converting other signals into electronical signals, graphene-based film shows its inherent advantages in responding to the tiny stimulations. In this review, the human-like senses and reflexes of graphene-based films are presented...
December 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/27966826/nanoreinforced-hydrogels-for-tissue-engineering-biomaterials-that-are-compatible-with-load-bearing-and-electroactive-tissues
#12
Mehdi Mehrali, Ashish Thakur, Christian Pablo Pennisi, Sepehr Talebian, Ayyoob Arpanaei, Mehdi Nikkhah, Alireza Dolatshahi-Pirouz
Given their highly porous nature and excellent water retention, hydrogel-based biomaterials can mimic critical properties of the native cellular environment. However, their potential to emulate the electromechanical milieu of native tissues or conform well with the curved topology of human organs needs to be further explored to address a broad range of physiological demands of the body. In this regard, the incorporation of nanomaterials within hydrogels has shown great promise, as a simple one-step approach, to generate multifunctional scaffolds with previously unattainable biological, mechanical, and electrical properties...
December 14, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27960585/challenges-for-the-application-of-optical-stimulation-in-the-cochlea-for-the-study-and-treatment-of-hearing-loss
#13
Rachael T Richardson, Alexander C Thompson, Andrew K Wise, Karina Needham
Electrical stimulation has long been the most effective strategy for evoking neural activity from bionic devices and has been used with great success in the cochlear implant to allow deaf people to hear speech and sound. Despite its success, the spread of electrical current stimulates a broad region of neural tissue meaning that contemporary devices have limited precision. Optical stimulation as an alternative has attracted much recent interest for its capacity to provide highly focused stimuli, and therefore, potentially improved sensory perception...
February 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/27939418/loudness-and-pitch-perception-using-dynamically-compensated-virtual-channels
#14
Waldo Nogueira, Leonid M Litvak, David M Landsberger, Andreas Büchner
Reducing power consumption is important for the development of smaller cochlear implant (CI) speech processors. Simultaneous electrode stimulation may improve power efficiency by minimizing the required current applied to a given electrode. Simultaneous in-phase stimulation on adjacent electrodes (i.e. virtual channels) can be used to elicit pitch percepts intermediate to the ones provided by each of the physical electrodes in isolation. Virtual channels are typically implemented in monopolar stimulation mode, producing broad excitation patterns...
December 7, 2016: Hearing Research
https://www.readbyqxmd.com/read/27935654/research-of-bionic-design-on-tools-with-rostrum-of-cyrtotrachelus-bugueti-guer-coleoptera-curculionidae
#15
Shun Xu, Longhai Li, Jin Tong, Mo Li
To improve the torsional resistance capability of multilayered composite pipes, a bionic design was presented based on the rostrum of Cyrtotrachelus Bugueti Guer. Morphology and mechanical properties of the weevil's rostrum were studied. Scanning electron microscope (SEM) was employed to observe the macro-/microstructure and inner structure. Nanoindentation was carried out to measure the elastic modulus and the hardness of the biological materials. Based on the structure of rostrum, a mathematical model of multilayered biomimetic pipe was established with the statistical methods...
December 9, 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27935211/bioinspired-special-wettability-surfaces-from-fundamental-research-to-water-harvesting-applications
#16
Songnan Zhang, Jianying Huang, Zhong Chen, Yuekun Lai
Nowadays, the pollution of water has become worse in many parts of the world, which causes a severe shortage of clean water and attracts widespread attention worldwide. Bioinspired from nature, i.e. spider silk, cactus, Namib desert beetle, Nepenthes alata, special wettability surfaces have attracted great interest from fundamental research to water-harvesting applications. Here, recently published literature about creatures possessing water-harvesting ability are reviewed, with a focus on the corresponding water-harvesting mechanisms of creatures in dry or arid regions, consisting of the theory of wetting and transporting...
December 9, 2016: Small
https://www.readbyqxmd.com/read/27934727/the-future-of-bionic-dynamos
#17
Canan Dagdeviren
No abstract text is available yet for this article.
December 2, 2016: Science
https://www.readbyqxmd.com/read/27934074/cancer-cell-membrane-biomimetic-nanoparticles-for-homologous-targeting-dual-modal-imaging-and-photothermal-therapy
#18
Ze Chen, Pengfei Zhao, Zhenyu Luo, Mingbin Zheng, Hao Tian, Ping Gong, Guanhui Gao, Hong Pan, Lanlan Liu, Aiqing Ma, Haodong Cui, Yifan Ma, Lintao Cai
An active cell membrane-camouflaged nanoparticle, owning to membrane antigens and membrane structure, can achieve special properties such as specific recognition, long blood circulation, and immune escaping. Herein, we reported a cancer cell membrane-cloaked nanoparticle system as a theranostic nanoplatform. The biomimetic nanoparticles (indocyanine green (ICG)-loaded and cancer cell membrane-coated nanoparticles, ICNPs) exhibit a core-shell nanostructure consisting of an ICG-polymeric core and cancer cell membrane shell...
November 22, 2016: ACS Nano
https://www.readbyqxmd.com/read/27901316/small-subcompartmentalized-microreactors-as-support-for-hepatocytes
#19
Yan Zhang, Marie Baekgaard-Laursen, Brigitte Städler
Mimicking specific structural or functional aspects of cells is considered a promising approach to substitute for missing or lost cellular functions. However, the interaction of such artificial assemblies with their biological counterparts including the exploitation of the activity of the synthetic partner remains thus-far a rather unexplored avenue. Herein, the assembly of active microreactors with similar size to hepatocytes is reported. These microreactors are successfully cocultured with hepatocytes into bionic tissue for up to 10 d...
November 30, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27879487/electrocochleography-in-cochlear-implant-recipients-with-residual-hearing-comparison-with-audiometric-thresholds
#20
Kanthaiah Koka, Aniket A Saoji, Leonid M Litvak
OBJECTIVES: To determine whether electrocochleography (ECoG) thresholds, especially cochlear microphonic and auditory nerve neurophonic thresholds, measured using an intracochlear electrode, can be used to predict pure-tone audiometric thresholds following cochlear implantation in ears with residual hearing. DESIGN: Pure-tone audiometric thresholds and ECoG waveforms were measured at test frequencies from 125 to 4000 Hz in 21 Advanced Bionics cochlear implant recipients with residual hearing in the implanted ear...
November 22, 2016: Ear and Hearing
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