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alzheimer's disease AND imaging

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https://www.readbyqxmd.com/read/28936489/landmark-based-alzheimer-s-disease-diagnosis-using-longitudinal-structural-mr-images
#1
Jun Zhang, Mingxia Liu, Le An, Yaozong Gao, Dinggang Shen
In this paper, we propose a landmark-based feature extraction method for AD diagnosis using longitudinal structural MR images, which requires no nonlinear registration or tissue segmentation in the application stage and is robust to the inconsistency among longitudinal scans. Specifically, (1) the discriminative landmarks are first automatically discovered from the whole brain, which can be efficiently localized using a fast landmark detection method for the testing images; (2) High-level statistical spatial features and contextual longitudinal features are then extracted based on those detected landmarks...
October 2016: Bayesian and Graphical Models for Biomedical Imaging: BAMBI 2014
https://www.readbyqxmd.com/read/28936280/enhancing-diffusion-mri-measures-by-integrating-grey-and-white-matter-morphometry-with-hyperbolic-wasserstein-distance
#2
Wen Zhang, Jie Shi, Jun Yu, Liang Zhan, Paul M Thompson, Yalin Wang
In order to improve the preclinical diagnose of Alzheimer's disease (AD), there is a great deal of interest in analyzing the AD related brain structural changes with magnetic resonance image (MRI) analyses. As the major features, variation of the structural connectivity and the cortical surface morphometry provide different views of structural changes to determine whether AD is present on presymptomatic patients. However, the large scale tensor-valued information and relatively low imaging resolution in diffusion MRI (dMRI) have created huge challenges for analysis...
2017: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
https://www.readbyqxmd.com/read/28934923/discriminative-sparse-features-for-alzheimer-s-disease-diagnosis-using-multimodal-image-data
#3
A Ortiz, F Lozano, J M Gorriz, J Ramírez, F J Martinez-Murci, For The Alzheimer S Disease Neuroimaging Initiative
BACKGROUND: Feature extraction in medical image processing still remains a challenge, especially in high-dimensionality datasets, where the expected number of available samples is considerably lower than the dimension of the feature space. This is a common problem in real-world data, and, specifically, in medical image pro- cessing as, while images are composed of hundreds of thousands voxels, only a reduced number of patients are available. OBJECTIVE: Extracting descriptive and discriminative features to represent each sample (image) by a small number of features, which is particularly important in classification task, due to the curse of dimensionality problem...
September 21, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28934374/the-effect-of-white-matter-hyperintensities-on-statistical-analysis-of-diffusion-tensor-imaging-in-cognitively-healthy-elderly-and-prodromal-alzheimer-s-disease
#4
Daniel Svärd, Markus Nilsson, Björn Lampinen, Jimmy Lätt, Pia C Sundgren, Erik Stomrud, Lennart Minthon, Oskar Hansson, Danielle van Westen
Diffusion tensor imaging (DTI) has been used to study microstructural white matter alterations in a variety of conditions including normal aging and Alzheimer's disease (AD). White matter hyperintensities (WMH) are common in cognitively healthy elderly as well as in AD and exhibit elevated mean diffusivity (MD) and reduced fractional anisotropy (FA). However, the effect of WMH on statistical analysis of DTI estimates has not been thoroughly studied. In the present study we address this in two ways. First, we investigate the effect of WMH on MD and FA in the dorsal and ventral cingulum, the superior longitudinal fasciculus, and the corticospinal tract, by comparing two matched groups of cognitively healthy elderly (n = 21 + 21) with unequal WMH load...
2017: PloS One
https://www.readbyqxmd.com/read/28932758/iterative-image-processing-for-early-diagnostic-of-beta-amyloid-plaque-deposition-in-pre-clinical-alzheimer-s-disease-studies
#5
Nikolai V Slavine, Padmakar V Kulkarni, Roderick W McColl
PURPOSE: To test and evaluate an efficient iterative image processing strategy to improve the quality of sub-optimal pre-clinical PET images. A novel iterative resolution subsets-based method to reduce noise and enhance resolution (RSEMD) has been demonstrated on examples of PET imaging studies of Alzheimer's disease (AD) plaques deposition in mice brains. MATERIALS AND METHODS: The RSEMD method was applied to imaging studies of non-invasive detection of beta-amyloid plaque in transgenic mouse models of AD...
August 2017: Journal of Applied Bioinformatics & Computational Biology
https://www.readbyqxmd.com/read/28931770/comparison-of-arterial-spin-labeling-perfusion-images-at-different-spatial-normalization-methods-based-on-voxel-based-statistical-analysis
#6
Kazuki Tani, Motohira Mio, Tatsuo Toyofuku, Shinichi Kato, Tomoya Masumoto, Tetsuya Ijichi, Masatoshi Matsushima, Shoichi Morimoto, Takumi Hirata
PURPOSE: Spatial normalization is a significant image pre-processing operation in statistical parametric mapping (SPM) analysis. The purpose of this study was to clarify the optimal method of spatial normalization for improving diagnostic accuracy in SPM analysis of arterial spin-labeling (ASL) perfusion images. METHODS: We evaluated the SPM results of five spatial normalization methods obtained by comparing patients with Alzheimer's disease or normal pressure hydrocephalus complicated with dementia and cognitively healthy subjects...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28930979/analysis-of-18fdg-pet-ct-imaging-as-a-tool-for-studying-mycobacterium-tuberculosis-infection-and-treatment-in-non-human-primates
#7
Alexander G White, Pauline Maiello, M Teresa Coleman, Jaime A Tomko, L James Frye, Charles A Scanga, Philana Ling Lin, JoAnne L Flynn
Mycobacterium tuberculosis remains the number one infectious agent in the world today. With the emergence of antibiotic resistant strains, new clinically relevant methods are needed that evaluate the disease process and screen for potential antibiotic and vaccine treatments. Positron Emission Tomography/Computed Tomography (PET/CT) has been established as a valuable tool for studying a number of afflictions such as cancer, Alzheimer's disease, and inflammation/infection. Outlined here are a number of strategies that have been employed to evaluate PET/CT images in cynomolgus macaques that are infected intrabronchially with low doses of M...
September 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28930568/medical-imaging-diagnosis-of-early-alzheimer-s-disease
#8
Fatma El-Zahraa A El-Gamal, Mohammed M Elmogy, Mohammed Ghazal, Ahmed Atwan, Manual F Casanova, Gregory N Barnes, Ayman El-Baz, Hassan Hajjdiab
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases that influences the central nervous system, often leading to dire consequences for quality of life. The disease goes through some stages mainly divided into early, moderate, and severe. Among them, the early stage is the most important as medical intervention has the potential to alter the natural progression of the condition. In practice, the early diagnosis is a challenge since the neurodegenerative changes can precede the onset of clinical symptoms by 10-15 years...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930562/alzheimer-s-disease-diagnostics-by-a-3d-deeply-supervised-adaptable-convolutional-network
#9
Ehsan Hosseini-Asl, Mohammed Ghazal, Ali Mahmoud, Ali Aslantas, Ahmed M Shalaby, Manual F Casanova, Gregory N Barnes, Georgy Gimel'farb, Robert Keynton, Ayman El-Baz
Early diagnosis is playing an important role in preventing progress of the Alzheimer's disease (AD). This paper proposes to improve the prediction of AD with a deep 3D Convolutional Neural Network (3D-CNN), which can show generic features capturing AD biomarkers extracted from brain images, adapt to different domain datasets, and accurately classify subjects with improved fine-tuning method. The 3D-CNN is built upon a convolutional autoencoder, which is pre-trained to capture anatomical shape variations in structural brain MRI scans for source domain...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930516/new-targeted-therapies-and-diagnostic-methods-for-iron-overload-diseases
#10
Annita Kolnagou, Christina N Kontoghiorghe, George John Kontoghiorghes
Millions of people worldwide suffer from iron overload toxicity diseases such as transfusional iron overload in thalassaemia and hereditary haemochromatosis. The accumulation and presence of toxic focal iron deposits causing tissue damage can also be identified in Friedreich's ataxia, Alzheimer's, Parkinson's, renal and other diseases. Different diagnostic criteria of toxicity and therapeutic interventions apply to each disease of excess or misplaced iron. Magnetic resonance imaging relaxation times T2 and T2* for monitoring iron deposits in organs and iron biomarkers such as serum ferritin and transferrin iron saturation have contributed in the elucidation of iron toxicity mechanisms and pathways, and also the evaluation of the efficacy and mode of action of chelating drugs in the treatment of diseases related to iron overload, toxicity and metabolism...
January 1, 2018: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28928740/microbiome-derived-lipopolysaccharide-enriched-in-the-perinuclear-region-of-alzheimer-s-disease-brain
#11
Yuhai Zhao, Lin Cong, Vivian Jaber, Walter J Lukiw
Abundant clinical, epidemiological, imaging, genetic, molecular, and pathophysiological data together indicate that there occur an unusual inflammatory reaction and a disruption of the innate-immune signaling system in Alzheimer's disease (AD) brain. Despite many years of intense study, the origin and molecular mechanics of these AD-relevant pathogenic signals are still not well understood. Here, we provide evidence that an intensely pro-inflammatory bacterial lipopolysaccharide (LPS), part of a complex mixture of pro-inflammatory neurotoxins arising from abundant Gram-negative bacilli of the human gastrointestinal (GI) tract, are abundant in AD-affected brain neocortex and hippocampus...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28928704/prediction-of-cognitive-decline-from-white-matter-hyperintensity-and-single-photon-emission-computed-tomography-in-alzheimer-s-disease
#12
Ken-Ichi Tabei, Hirotaka Kida, Tetsuo Hosoya, Masayuki Satoh, Hidekazu Tomimoto
BACKGROUND: While several studies support an association of white matter hyperintensity (WMH) volume and regional cerebral blood flow (rCBF) with cognitive decline in Alzheimer's disease (AD), no reports have simultaneously considered the effects of both factors on cognitive decline. OBJECTIVE: The purpose of the present study was to compare WMH volume and rCBF in relation to cognitive function by developing a new software program to fuse magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) data...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28927833/modulation-of-hippocampal-activity-with-fornix-deep-brain-stimulation
#13
Paul H Stypulkowski, Scott R Stanslaski, Jonathon E Giftakis
BACKGROUND: Deep Brain Stimulation (DBS) within the Papez circuit is under investigation as a treatment for epilepsy and Alzheimer's disease. We previously reported the effects of stimulation at nodes within this network (anterior thalamic nucleus and hippocampus) on hippocampal activity in a large animal model, using a chronic implantable, clinical-grade system that permits concurrent stimulation and recording. OBJECTIVE: In this study we extended earlier work to compare the effects of fornix DBS on evoked potentials (EPs) and local field potential (LFP) activity within the hippocampus, and to assess closed-loop stimulation...
September 6, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28926133/synthesis-of-thiophene-based-optical-ligands-that-selectively-detect-tau-pathology-in-alzheimer%C3%A2-s-disease
#14
Peter Nilsson, Hamid Shirani, Hanna Appelqvist, Marcus Bäck, Therese Klingstedt, Nigel Cairns
The accumulation of protein aggregates is associated with many devastating neurodegenerative diseases and the development of molecular ligands able to detect these pathological hallmarks is essential. Here, we report the synthesis of thiophene based optical ligands, denoted bi-thiophene-vinyl-benzothiazoles (bTVBTs) that can be utilized for selective assignment of tau aggregates in brain tissue with Alzheimer´s disease (AD) pathology. The ability of the ligands to selectively distinguish tau deposits from the other AD associated pathological hallmark, senile plaques consisting of aggregated amyloid-β (Aβ) peptide, were reduced when the chemical composition of the ligands were altered, verifying that specific molecular interactions between the ligands and the aggregates are necessary for the selective detection of tau deposits...
September 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28925253/novel-trimodal-maldi-imaging-mass-spectrometry-ims3-at-10-%C3%AE-m-reveals-spatial-lipid-and-peptide-correlates-implicated-in-a%C3%AE-plaque-pathology-in-alzheimer-s-disease
#15
Ibrahim Kaya, Dimitri Brinet, Wojciech Michno, Mehmet Baskurt, Henrik Zetterberg, Kaj Blennow, Jörg Hanrieder
Multimodal chemical imaging using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) can provide comprehensive molecular information in situ within the same tissue sections. This is of relevance for studying different brain pathologies such as Alzheimer's Disease (AD), where recent data suggest a critical relevance of co-localizing Aβ peptides and neuronal lipids. We here developed a novel trimodal, high-resolution (10µm) MALDI imaging MS (IMS) paradigm for negative- and positive ion mode lipid analysis and subsequent protein ion imaging on the same tissue section...
September 19, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28922157/longer-term-investigation-of-the-value-of-18f-fdg-pet-and-magnetic-resonance-imaging-for-predicting-the-conversion-of-mild-cognitive-impairment-to-alzheimer-s-disease-a-multicenter-study
#16
Yoshitaka Inui, Kengo Ito, Takashi Kato
BACKGROUND: The value of fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) and magnetic resonance imaging (MRI) for predicting conversion of mild cognitive impairment (MCI) to Alzheimer's disease (AD) in longer-term is unclear. OBJECTIVE: To evaluate longer-term prediction of MCI to AD conversion using 18F-FDG-PET and MRI in a multicenter study. METHODS: One-hundred and fourteen patients with MCI were followed for 5 years...
September 11, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28922150/synthesis-radiosynthesis-and-preliminary-in-vitro-and-in-vivo-evaluation-of-the-fluorinated-ceramide-trafficking-inhibitor-hpa-12-for-brain-applications
#17
Simone M Crivelli, Andreas Paulus, Jozef Markus, Matthias Bauwens, Dusan Berkes, Helga E De Vries, Monique T Mulder, Jochen Walter, Felix M Mottaghy, Mario Losen, Pilar Martinez-Martinez
Ceramide levels are increased in blood and brain tissue of Alzheimer's disease (AD) patients. Since the ceramide transporter protein (CERT) is the only known protein able to mediate non-vesicular transfer of ceramide between organelle membranes, the modulation of CERT function may impact on ceramide accumulation. The competitive CERT inhibitor N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl) dodecanamide (HPA-12) interferes with ceramide trafficking. To understand the role of ceramide/CERT in AD, HPA-12 can be a useful tool to modulate ceramide trafficking...
September 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28922067/conceptual-elaboration-versus-direct-lexical-access-in-wais-similarities-differential-effects-of-white-matter-lesions-and-gray-matter-volumes
#18
Sven-Erik Fernaeus, Åke Hellström
Wechsler Adult Intelligence Scale (WAIS) subscale Similarities have been classified as a test of either verbal comprehension or of inductive reasoning. The reason may be that items divide into two categories. We tested the hypothesis of heterogeneity of items in WAIS-Similarities. Consecutive patients at a memory clinic and healthy controls participated in the study. White-matter hyperintensities (WMHs) and normalized temporal lobe volumes were measured based on Magnetic resonance Imaging (MRI), and tests of verbal memory and attention were used in addition to WAIS-Similarities to collect behavioural data...
September 18, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/28921611/dendritic-spines-provide-cognitive-resilience-against-alzheimer-s-disease
#19
Benjamin D Boros, Kelsey M Greathouse, Erik G Gentry, Kendall A Curtis, Elizabeth L Birchall, Marla Gearing, Jeremy H Herskowitz
OBJECTIVE: Neuroimaging and other biomarker assays suggest that the pathological processes of Alzheimer's disease (AD) initiate years prior to clinical dementia onset. However some 30%-50% of older individuals that harbor AD pathology do not become symptomatic in their lifetime. It is hypothesized that such individuals exhibit cognitive resilience that protects against AD dementia. We hypothesized that in cases with AD pathology structural changes in dendritic spines would distinguish individuals that had or did not have clinical dementia...
September 16, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28919280/soluble-gamma-secretase-modulators-attenuate-alzheimer-s-%C3%AE-amyloid-pathology-and-induce-conformational-changes-in-presenilin-1
#20
Frank Raven, Joseph F Ward, Katarzyna M Zoltowska, Yu Wan, Enjana Bylykbashi, Sean J Miller, Xunuo Shen, Se Hoon Choi, Kevin D Rynearson, Oksana Berezovska, Steven L Wagner, Rudolph E Tanzi, Can Zhang
A central pathogenic event of Alzheimer's disease (AD) is the accumulation of the Aβ42 peptide, which is generated from amyloid-β precursor protein (APP) via cleavages by β- and γ-secretase. We have developed a class of soluble 2-aminothiazole γ-secretase modulators (SGSMs) that preferentially decreases Aβ42 levels. However, the effects of SGSMs in AD animals and cells expressing familial AD mutations, as well as the mechanism of γ-secretase modulation remain largely unknown. Here, a representative of this SGSM scaffold, SGSM-36, was investigated using animals and cells expressing FAD mutations...
September 4, 2017: EBioMedicine
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