keyword
https://read.qxmd.com/read/38485683/quercetin-enhances-5-fluorouracil-sensitivity-by-regulating-the-autophagic-flux-and-inducing-drp-1-mediated-mitochondrial-fragmentation-in-colorectal-cancer-cells
#21
JOURNAL ARTICLE
Mei Li, Jiaoxiu Fan, Min Hu, Junyu Xu, Ziyue He, Jun Zeng
BACKGROUND: While chemotherapy treatment demonstrates its initial effectiveness in eliminating the majority of the tumor cell population, nevertheless, most patients relapse and eventually succumb to the disease upon its recurrence. One promising approach is to explore novel, effective chemotherapeutic adjuvants to enhance the sensitivity of cancer cells to conventional chemotherapeutic agents. In the present study, we explored the effect of quercetin on the sensitivity of colorectal cancer (CRC) cells to conventional chemotherapeutic agent 5-fluorouracil (5-FU) and the molecular mechanisms...
February 27, 2024: Current Molecular Pharmacology
https://read.qxmd.com/read/38485345/effects-of-d-allose-on-atp-production-and-cell-viability-in-neonatal-rat-cardiomyocytes
#22
JOURNAL ARTICLE
Xi Chen, Asadur Rahman, Steeve Akumwami, Asahiro Morishita, Kento Kitada, Yasumasa Ikeda, Masafumi Funamoto, Akira Nishiyama
2-Deoxy-d-glucose (2DG) induces anticancer effects through glycolytic inhibition but it may raise the risk of arrhythmia. The rare monosaccharide d-allose also has anticancer properties, but its cardiac effects are unknown. We examined the effects of d-allose on adenosine triphosphate (ATP) production in neonatal rat cardiomyocytes. We showed that 25 mM d-allose selectively reduced glycolytic ATP, but had minimal impact on mitochondrial ATP, while 1 mM 2DG strongly inhibited both. Furthermore, d-allose had less impact on cell viability and was less cytotoxic than 2DG; neither compound caused apoptosis...
April 2024: Journal of Pharmacological Sciences
https://read.qxmd.com/read/38485001/perfluorooctane-sulfonate-pfos-and-its-selected-analogs-induce-various-cell-death-types-in-peripheral-blood-mononuclear-cells
#23
JOURNAL ARTICLE
Katarzyna Mokra, Izabela Kaczmarska, Bożena Bukowska
The perfluoalkyl substance (PFASs) perfluorooctane sulfonate (PFOS) has been widely used in industry. However, PFOS is a persistent organic pollutant and has been gradually replaced by its short-chain analogs, perfluorohexane sulfonate (PFHxS) and perfluorobutane sulfonate (PFBS). PFASs are extremely persistent and are very frequently detected among the general population. The aim of the study was to determine the effect of selected PFASs on peripheral blood mononuclear cells (PBMCs) and the mechanisms of their action...
March 12, 2024: Chemosphere
https://read.qxmd.com/read/38484831/ph-responsive-size-adjustable-liposomes-induce-apoptosis-of-fibroblasts-and-macrophages-for-rheumatoid-arthritis-treatment
#24
JOURNAL ARTICLE
Xiu Zheng, Hong Yang, Zongquan Zhang, Xiaoya Liang, Yan Liu, Chenglong Wang, Xi Yang, Jun Tang, Jingying Mao, Yu Nie, Xiangyu Zhou, Chunhong Li
In rheumatoid arthritis (RA), macrophages infiltrate joints, while fibroblast-like synovial cells proliferate abnormally, forming a barrier against drug delivery, which hinders effective drug delivery to joint focus. Here we firstly designed a pH-responsive size-adjustable nanoparticle, composed by methotrexate (MTX)-human serum albumin (HSA) complex coating with pH-responsive liposome (Lipo/MTX-HSA) for delivering drugs specifically to inflamed joints in acidic environments. We showed in vitro that the nanoparticles can induce mitochondrial dysfunction, promote apoptosis of fibroblast-like synoviocytes and macrophages, further reduce the secretion of inflammatory factors (TNF-α, IL-1β, MMP-9), and regulate the inflammatory microenvironment...
March 12, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38484665/a-novel-hdac6-inhibitor-attenuate-apap-induced-liver-injury-by-regulating-mdh1-mediated-oxidative-stress
#25
JOURNAL ARTICLE
Guo-Dong Zhang, Li-Li Wang, Ling Zheng, Shi-Qi Wang, Rong-Quan Yang, Yu-Ting He, Jun-Wei Wang, Ming-Yu Zhao, Yi Ding, Mei Liu, Tian-Yu Yang, Bao-Ming Wu, Hao Cui, Lei Zhang
Glutathione (GSH) depletion, mitochondrial damage, and oxidative stress have been implicated in the pathogenesis of acetaminophen (APAP) hepatotoxicity. Here, we demonstrated that the expression of histone deacetylase 6 (HDAC6) is highly elevated, whereas malate dehydrogenase 1 (MDH1) is downregulated in liver tissues and AML-12 cells induced by APAP. The therapeutic benefits of LT-630, a novel HDAC6 inhibitor on APAP-induced liver injury, were also substantiated. On this basis, we demonstrated that LT-630 improved the protein expression and acetylation level of MDH1...
March 13, 2024: International Immunopharmacology
https://read.qxmd.com/read/38483766/investigation-of-the-mutual-crosstalk-between-er-stress-and-pi3k-akt-mtor-signaling-pathway-in-iron-overload-induced-liver-injury-in-chicks
#26
JOURNAL ARTICLE
Xiang-Long Lv, Wen-Lei Li, Feng-Jiao Sun, Yu-Zhi An, Ning Sun, Xiao-Ping Lv, Xue-Li Gao
Iron is an essential element for the normal functioning of living organisms, but excessive iron deposition can lead to organ damage. This study aims to investigate the interaction between the endoplasmic reticulum stress signaling pathway and the PI3K/AKT/mTOR signaling pathway in liver injury induced by iron overload in chicks. Rspectively, 150 one-day-old broilers were divided into three groups and supplemented with 50 (C), 500 (E1), and 1000 (E2) mg ferrous sulfate monohydrate/kg in the basal diet. Samples were taken after continuous feeding for 14 days...
March 14, 2024: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/38483755/pharmacological-insights-mitochondrial-ros-generation-by-fnc-azvudine-in-dalton-s-lymphoma-cells-revealed-by-super-resolution-imaging
#27
JOURNAL ARTICLE
Naveen Kumar, Vikram Delu, Ilya Ulasov, Sanjay Kumar, Rishi Kant Singh, Sandeep Kumar, Alok Shukla, Anand Kumar Patel, Lokesh Yadav, Ruchi Tiwari, Kumari Rachana, Shivashish Priyadarshi Mohanta, Varsha Singh, Anuradha Yadav, Kaushalendra Kaushalendra, Arbind Acharya
Nucleoside analogs are a common form of chemotherapy that disrupts DNA replication and repair, leading to cell cycle arrest and apoptosis. Reactive oxygen species (ROS) production is a significant mechanism through which these drugs exert their anticancer effects. This study investigated a new nucleoside analog called FNC or Azvudine, and its impact on ROS production and cell viability in Dalton's lymphoma (DL) cells. The study found that FNC treatment resulted in a time- and dose-dependent increase in ROS levels in DL cells...
March 14, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38482171/sodium-butyrate-impedes-the-lymphoma-caused-by-marek-s-disease-virus-via-regulating-the-mitochondrial-apoptosis-pathway
#28
JOURNAL ARTICLE
Qiaoer Lin, Jun Zhou, Fan Yang, Congsen Zheng, Meiting Chen, Chuanzhe Chang, Shikai Cai, Feng Wen, Nina Wang, Yanfeng Chen, Limei Qin
Sodium butyrate (NaB) has garnered attention in recent years for its ability to impede the malignant progression of tumors. In order to explore the potential inhibitory effects of NaB on the replication of Marek's disease virus (MDV) and subsequent lymphoma formation, newly hatched chickens were infected with the vvMDV Md5 strain and administered NaB prior to (prevention group) or following (treatment group) Md5 inoculation. The results revealed that NaB played a pivotal role in diminishing both the incidence and fatality rates in chickens afflicted with Md5 infection...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38481810/the-fto-cmpk2-pathway-in-fibroblast-like-synoviocytes-modulates-rheumatoid-arthritis-synovial-inflammation-and-cartilage-homeostasis-via-mtdna-regulation
#29
JOURNAL ARTICLE
Li Jin, Qiyue Chen, Ke Hu, Dandan Fan, Heping Zhang, Jiaxin Deng, Weizhong Qi, Qinghong Yu
In rheumatoid arthritis (RA), a debilitating autoimmune disorder marked by chronic synovial inflammation and progressive cartilage degradation, fibroblast-like synoviocytes (FLS) are key pathogenic players. Current treatments targeting these cells are limited. Our study focused on the Fat Mass and Obesity-associated protein (FTO), known for its roles in cell proliferation and inflammatory response modulation, and its involvement in RA. We specifically examined the inflammatory regulatory roles of FTO and CMPK2, a mitochondrial DNA synthesis protein, in FLS...
2024: International Journal of Biological Sciences
https://read.qxmd.com/read/38481287/global-gene-expression-profiling-of-perirenal-brown-adipose-tissue-whitening-in-goat-kids-reveals-novel-genes-linked-to-adipose-remodeling
#30
JOURNAL ARTICLE
Le Zhao, Haili Yang, Minhao Li, Min Xiao, Xingchun Li, Lei Cheng, Wenqiang Cheng, Meixi Chen, Yongju Zhao
BACKGROUND: Brown adipose tissue (BAT) is known to be capable of non-shivering thermogenesis under cold stimulation, which is related to the mortality of animals. In the previous study, we observed that goat BAT is mainly located around the kidney at birth, and changes to white adipose tissue (WAT) in the perirenal adipose tissue of goats within one month after birth. However, the regulatory factors underlying this change is remain unclear. In this study, we systematically studied the perirenal adipose tissue of goat kids in histological, cytological, and accompanying molecular level changes from 0 to 28 d after birth...
March 14, 2024: Journal of Animal Science and Biotechnology
https://read.qxmd.com/read/38480845/prodh-safeguards-human-naive-pluripotency-by-limiting-mitochondrial-oxidative-phosphorylation-and-reactive-oxygen-species-production
#31
JOURNAL ARTICLE
Cheng Chen, Qianyu Liu, Wenjie Chen, Zhiyuan Gong, Bo Kang, Meihua Sui, Liming Huang, Ying-Jie Wang
Naive human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-localized proline metabolism enzyme, is dramatically upregulated in naive hESCs compared to their primed counterparts. The upregulation of PRODH is induced by a reduction in c-Myc expression that is dependent on PD0325901, a MEK inhibitor routinely present in naive hESC culture media...
March 13, 2024: EMBO Reports
https://read.qxmd.com/read/38480798/nortriptyline-hydrochloride-a-potential-candidate-for-drug-repurposing-inhibits-gastric-cancer-by-inducing-oxidative-stress-by-triggering-the-keap1-nrf2-pathway
#32
JOURNAL ARTICLE
Chunyang Zhu, Yangyang Lu, Shasha Wang, Jialin Song, Yixin Ding, Yan Wang, Chen Dong, Jiani Liu, Wensheng Qiu, Weiwei Qi
Effective drugs for the treatment of gastric cancer (GC) are still lacking. Nortriptyline Hydrochloride (NTP), a commonly used antidepressant medication, has been demonstrated by numerous studies to have antitumor effects. This study first validated the ability of NTP to inhibit GC and preliminarily explored its underlying mechanism. To begin with, NTP inhibits the activity of AGS and HGC27 cells (Human-derived GC cells) in a dose-dependent manner, as well as proliferation, cell cycle, and migration. Moreover, NTP induces cell apoptosis by upregulating BAX, BAD, and c-PARP and downregulating PARP and Bcl-2 expression...
March 13, 2024: Scientific Reports
https://read.qxmd.com/read/38479556/early-b-cell-factor-3-ebf3-attenuates-parkinson-s-disease-through-directly-regulating-contactin-associated-protein-like-4-cntnap4-transcription-an-experimental-study
#33
JOURNAL ARTICLE
Wentao Hu, Menghan Wang, Guifang Sun, Limin Zhang, Hong Lu
Parkinson's disease (PD) is a gradually debilitating neurodegenerative syndrome. Here, we analyzed GSE7621 chip data obtained from the Gene Expression Omnibus (GEO) database to explore the pathogenesis of PD. Early B Cell Factor 3 (EBF3), a member of the highly evolutionarily conserved EBF-transcription factor family, is involved in neuronal development. EBF3 expression is low in the substantia nigra of patients with PD. However, whether EBF3 is implicated in dopaminergic neuron death during PD has not yet been investigated...
March 11, 2024: Cellular Signalling
https://read.qxmd.com/read/38479314/polystyrene-microplastics-impair-the-functions-of-cultured-mouse-leydig-tm3-and-sertoli-tm4-cells-by-inducing-mitochondrial-endoplasmic-reticulum-damage
#34
JOURNAL ARTICLE
Giulia Grillo, Sara Falvo, Debora Latino, Gabriella Chieffi Baccari, Massimo Venditti, Maria Maddalena Di Fiore, Sergio Minucci, Alessandra Santillo
Many laboratory studies demonstrated that the exposure to microplastics causes testosterone deficiency and spermatogenic impairment in mammals; however, the mechanism underlying this process remains still unclear. In this study, we investigated the effects of polystyrene microplastics (PS-MP) on the proliferation and functionality of cultured Leydig (TM3) and Sertoli (TM4) cells, focusing on the mitochondrial compartment and its association with the endoplasmic reticulum (ER). The in vitro exposure to PS-MP caused a substantial reduction in cellular viability in TM3 and TM4 cells...
March 12, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38479243/nobiletin-enhances-mitochondrial-function-by-regulating-sirt1-pgc-1%C3%AE-signaling-in-porcine-oocytes-during-in-vitro-maturation
#35
JOURNAL ARTICLE
Song-Hee Lee, Xiao-Han Li, Qin-Yue Lu, Cheng-Lin Zhan, Ji-Dam Kim, Gyu-Hyun Lee, Jae-Min Sim, Xiang-Shun Cui
Nobiletin is a natural flavonoid found in citrus fruits with beneficial effects, including anti-inflammatory, anti-cancer and anti-oxidation effects. The aim of this study was to investigate whether nobiletin improves mitochondrial function in porcine oocytes and examine the underlying mechanism. Oocytes enclosed by cumulus cells were cultured in TCM-199 for 44 h with 0.1% dimethyl sulfoxide (control), or supplemented with 5, 10, 25, and 50 μM of nobiletin (Nob5, Nob10, Nob25, and Nob50, respectively)...
March 5, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38478195/effects-of-the-glucocorticoid-mediated-mitochondrial-translocation-of-glucocorticoid-receptors-on-oxidative-stress-and-pyroptosis-in-bv-2-microglia
#36
JOURNAL ARTICLE
Ruonan Dang, Xuyang Hou, Xinglan Huang, Caifeng Huang, Xiaoqing Zhao, Xingrong Wang, Ning Zhang, Yuqi Yang, Nan Li, Sheng Liu, Peng Yan, Ping Fan, Xinghua Song, Suiying Zhang, Yuqiong Deng, Xiping Cheng, Xinhua Xia
Microglia are resident macrophages within the central nervous system, serving as the first responders to neuroinflammation. Glucocorticoids (GCs) may cause damage to brain tissue, but the specific mechanism remains unclear. This study was divided into two parts: a glucocorticoid receptor (GR) mitochondrial translocation intervention experiment and a mitochondrial oxidative stress inhibition experiment. BV-2 microglia were stimulated with dexamethasone (DEX) and treated with either tubastatin-A or mitoquinone (MitoQ) for 24 h...
March 13, 2024: Journal of Molecular Neuroscience: MN
https://read.qxmd.com/read/38478170/fam83b-regulates-mitochondrial-metabolism-and-anti-apoptotic-activity-in-pulmonary-adenocarcinoma
#37
JOURNAL ARTICLE
Jiajia Wang, Panpan Li, Limin Sun, Jing Zhang, Ke Yue, Yan Wang, Xiaojuan Wu
Chemotherapy is an effective therapeutic modality; nevertheless, a significant proportion of patients diagnosed with lung adenocarcinoma (LUAD) demonstrate resistance to chemotherapy. Therefore, it is crucial to understand the potential regulatory mechanisms to develop novel treatment strategies. This study aims to understand how increased FAM83B expression impacts mitochondrial activity, cell apoptosis, and chemotherapy effectiveness in LUAD. Multiple assays, such as CCK8, wound healing, EdU, and transwell assays, were employed to confirm the augmented chemotherapy resistance, heightened cell proliferation, migration, and invasion caused by FAM83B overexpression in LUAD cells...
March 13, 2024: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/38477698/erythrocyte-membrane-camouflaged-nanotheranostics-for-optical-molecular-imaging-escorted-self-oxygenation-photodynamic-therapy
#38
JOURNAL ARTICLE
Yilin Wan, Chunying Li, Lian-Hua Fu, Ting Feng, Yifan Zhang, Youyan Li, Jing Lin, Peng Huang, Da-Xiang Cui
Hypoxic tumor microenvironment (TME) hampers the application of oxygen (O2 )-dependent photodynamic therapy (PDT) in solid tumors. To address this problem, a biomimetic nanotheranostics (named MMCC@EM) is developed for optical molecular imaging-escorted self-oxygenation PDT. MMCC@EM is synthesized by encapsulating chlorin e6 (Ce6) and catalase (CAT) in metal-organic framework (MOF) nanoparticles with erythrocyte membrane (EM) camouflage. Based on the biomimetic properties of EM, MMCC@EM efficiently accumulates in tumor tissues...
March 13, 2024: Small
https://read.qxmd.com/read/38476912/erratum-corrigendum-relationship-between-changes-in-mitochondrial-function-and-hippocampal-neuronal-apoptosis-after-recurrent-convulsion-during-developmental-stage
#39
Yueying Liu, Jieru Chen, Meifang Jin, Zhenhong Li, Tian Tian, Lili Li, Hong Ni
[This corrects the article DOI: 10.3892/etm.2018.6147.].
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38476170/the-characterization-of-cellrox%C3%A2-probes-could-be-a-crucial-factor-in-ram-sperm-quality-assessment
#40
JOURNAL ARTICLE
Cristina Palacin-Martinez, Luis Anel-Lopez, Mercedes Alvarez, Marta Neila-Montero, Rafael Montes-Garrido, Cristina Soriano-Úbeda, Paulino de Paz, Luis Anel, Marta F Riesco
Several authors have demonstrated that low levels of reactive oxygen species (ROS) are necessary for the physiological functions of sperm, such as capacitation, hyperactivation, acrosomal reaction and fertilization. However, high levels of ROS are associated with oxidative stress and detrimental effects on fertility. Consequently, deep characterization of ROS presence using different fluorescent probes could be crucial. In this sense, the study of intracellular ROS localization and the relationships between ROS and other conventional parameters could improve the characterization of sperm quality for semen preservation protocols in rams...
2024: Frontiers in Veterinary Science
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