keyword
https://read.qxmd.com/read/38493450/aglycemia-induces-apoptosis-under-hypoxic-conditions-in-a549-cells
#1
JOURNAL ARTICLE
Yüksel Öğünç Keçeci, Zerrin İncesu
Many of the cancer cells produce energy with accelerated glycolysis and perform lactic acid production even under normoxic conditions called the "Warburg effect". Metabolism can directly or indirectly regulate the apoptotic mechanism so that cancer cells take advantage of reprogrammed metabolism to avoid apoptosis. The aim of this study is to examine the mechanism of apoptosis by incubating human lung carcinoma cells (A549) under different metabolic conditions in hypoxia or normoxia environments. A549 cells were incubated in the normoxic or hypoxic condition that contained 5 mM glucose (Glc 5), 25 mM glucose (Glc 25), or 10 mM galactose (OXPHOS/aglycemic), and the mechanism of apoptosis was investigated...
March 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38493408/a-novel-mitochondrial-unfolded-protein-response-related-risk-signature-to-predict-prognosis-immunotherapy-and-sorafenib-sensitivity-in-hepatocellular-carcinoma
#2
JOURNAL ARTICLE
Sidi Zhang, Hanyao Guo, Hongyu Wang, Xiaopeng Liu, Meixia Wang, Xiaoyu Liu, Yumei Fan, Ke Tan
Hepatocellular carcinoma (HCC) is a common cause of cancer-associated death worldwide. The mitochondrial unfolded protein response (UPRmt ) not only maintains mitochondrial integrity but also regulates cancer progression and drug resistance. However, no study has used the UPRmt to construct a prognostic signature for HCC. This work aimed to establish a novel signature for predicting patient prognosis, immune cell infiltration, immunotherapy, and chemotherapy response based on UPRmt -related genes (MRGs). Transcriptional profiles and clinical information were obtained from the TCGA and ICGC databases...
March 17, 2024: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/38492796/armcx1-reduces-neurological-damage-via-a-mitochondrial-transport-pathway-involving-miro1-after-traumatic-brain-injury
#3
JOURNAL ARTICLE
Qiuying Li, Haibo Ni, Qin Rui, Jiasheng Ding, Xianghu Kong, Xugang Kan, Rong Gao, Hongbo Shen
Armcx1 is a member of the ARMadillo repeat-Containing protein on the X chromosome (ARMCX) family, which is recognized to have evolutionary conserved roles in regulating mitochondrial transport and dynamics. Previous research has shown that Armcx1 is expressed at higher levels in mice after axotomy and in adult retinal ganglion cells after crush injury, and this protein increases neuronal survival and axonal regeneration. However, its role in traumatic brain injury (TBI) is unclear. Therefore, the aim of this study was to assess the expression of Armcx1 after TBI and to explore possible related mechanisms by which Armcx1 is involved in TBI...
March 14, 2024: Neuroscience
https://read.qxmd.com/read/38492782/inhibition-of-cisd1-attenuates-cisplatin-induced-hearing-loss-in-mice-via-the-pi3k-and-mapk-pathways
#4
JOURNAL ARTICLE
Wenqi Dong, Yumeng Jiang, Qinxiu Yao, Maoxiang Xu, Yuchen Jin, Lingkang Dong, Zhuangzhuang Li, Dongzhen Yu
Cisplatin is an effective chemotherapeutic drug for different cancers, but it also causes severe and permanent hearing loss. Oxidative stress and mitochondrial dysfunction in cochlear hair cells (HCs) have been shown to be important in the pathogenesis of cisplatin-induced hearing loss (CIHL). CDGSH iron sulfur domain 1 (CISD1, also termed mitoNEET) plays a critical role in mitochondrial oxidative capacity and cellular bioenergetics. Targeting CISD1 may improve mitochondrial function in various diseases. However, the role of CISD1 in cisplatin-induced ototoxicity is unclear...
March 14, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38492518/human-parainfluenza-virus-type-2-v-protein-inhibits-mitochondrial-apoptosis-pathway-through-two-ways
#5
JOURNAL ARTICLE
Naoki Saka, Machiko Nishio, Keisuke Ohta
Paramyxoviruses are reported to block apoptosis for their replication, but the mechanisms remain unclear. Furthermore, regulation of mitochondrial apoptosis by paramyxoviruses has been hardly reported. We investigated whether and how human parainfluenza virus type 2 (hPIV-2) counteracts apoptosis. Infection of recombinant hPIV-2 carrying mutated V protein showed higher caspase 3/7 activity and higher cytochrome c release from mitochondria than wild type hPIV-2 infection. This indicates that V protein controls mitochondrial apoptosis pathway...
March 11, 2024: Virology
https://read.qxmd.com/read/38492416/a-novel-homozygous-nonsense-variant-of-ak7-is-associated-with-multiple-morphological-abnormalities-of-the-sperm-flagella
#6
JOURNAL ARTICLE
Tianli Chang, Hongying Tang, Xu Zhou, Jingliang He, Nenghui Liu, Yanping Li, Wenpei Xiang, Zhongyuan Yao
RESEARCH QUESTION: Is the novel homozygous nonsense variant of AK7 associated with multiple morphological abnormalities of the sperm flagella (MMAF), a specific type of oligoasthenoteratozoospermia leading to male infertility? DESIGN: Whole-exome sequencing and Sanger sequencing were performed to identify potential gene variants. Immunoblotting and immunofluorescence were applied to confirm the relationship between mutated genes and disease phenotypes. The concentration of reactive oxygen species and the rate of apoptosis were measured to evaluate the mitochondrial function of spermatozoa...
December 8, 2023: Reproductive Biomedicine Online
https://read.qxmd.com/read/38492365/total-paeony-glycoside-relieves-neuroinflammation-to-exert-antidepressant-effect-via-the-interplay-between-nlrp3-inflammasome-pyroptosis-and-autophagy
#7
JOURNAL ARTICLE
Lili Su, Haoyu Lu, Dongxue Zhang, Xiaoying Zhu, Jianming Li, Ying Zong, Yan Zhao, Zhongmei He, Weijia Chen, Rui Du
BACKGROUND: Depression is a common mental illness characterised by abnormal and depressed emotions. Total paeony glycoside (TPG) is a naturally active saponin extracted from the traditional Chinese medicine Radix Paeoniae rubra. However, the antidepressant and neuroinflammatory effects of TPG have not been thoroughly studied. PURPOSE: To study the therapeutic potential of TGP in depression caused by neuronal injury and neuroinflammation and to explore the mechanism of TGP and the relationship between the NLRP3 inflammasome, pyroptosis, and autophagy...
March 8, 2024: Phytomedicine
https://read.qxmd.com/read/38491972/platycodin-d-ameliorates-cognitive-impairment-in-type-2-diabetes-mellitus-mice-via-regulating-pi3k-akt-gsk3%C3%AE-signaling-pathway
#8
JOURNAL ARTICLE
Ya-Wei Lu, Li-Ya Xie, Meng-Han Qi, Shen Ren, Yue-Qi Wang, Jun-Nan Hu, Zi Wang, Shan Tang, Jing-Tian Zhang, Wei Li
Objectives: The aim of this study was to investigate the ameliorative effect of platycodin D (PD) on cognitive dysfunction in type 2 diabetes mellitus (T2DM) and its potential molecular mechanisms of action in vivo and in vitro. Materials and methods: An animal model of cognitive impairment in T2DM was established using a single intraperitoneal injection of streptozotocin (100 mg/kg) after 8 weeks of feeding a high-fat diet to C57BL/6 mice. In vitro, immunofluorescence staining and Western blot were employed to analyze the effects of PD on glucose-induced neurotoxicity in mouse hippocampal neuronal cells (HT22)...
March 16, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38490981/plekhm2-deficiency-induces-impaired-mitochondrial-clearance-and-elevated-ros-levels-in-human-ipsc-derived-cardiomyocytes
#9
JOURNAL ARTICLE
Jianchao Zhang, Ying Peng, Wanrong Fu, Ruifei Wang, Jinhua Cao, Shuang Li, Xiaoxu Tian, Zhonggen Li, Chongpei Hua, Yafei Zhai, Yangyang Liu, Mengduan Liu, Jihong Sun, Xiaowei Li, Xiaoyan Zhao, Jianzeng Dong
Pleckstrin homology domain-containing family M member 2 (PLEKHM2) is an essential adaptor for lysosomal trafficking and its homozygous truncation have been reported to cause early onset dilated cardiomyopathy (DCM). However, the molecular mechanism of PLEKHM2 deficiency in DCM pathogenesis and progression is poorly understood. Here, we generated an in vitro model of PLEKHM2 knockout (KO) induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to elucidate the potential pathogenic mechanism of PLEKHM2-deficient cardiomyopathy...
March 15, 2024: Cell Death Discovery
https://read.qxmd.com/read/38490643/quercetin-attenuates-cisplatin-induced-mitochondrial-apoptosis-via-pi3k-akt-mediated-inhibition-of-oxidative-stress-in-pericytes-and-improves-the-blood-labyrinth-barrier-permeability
#10
JOURNAL ARTICLE
Tian-Lan Huang, Wen-Jun Jiang, Zan Zhou, Tian-Feng Shi, Miao Yu, Meng Yu, Jun-Qiang Si, Yan-Ping Wang, Li Li
Cisplatin (CDDP) is broadly employed to treat different cancers, whereas there are no drugs approved by the Food and Drug Administration (FDA) for preventing its side effects, including ototoxicity. Quercetin (QU) is a widely available natural flavonoid compound with anti-tumor and antioxidant properties. The research was designed to explore the protective effects of QU on CDDP-induced ototoxicity and its underlying mechanisms in male C57BL/6 J mice and primary cultured pericytes (PCs). Hearing changes, morphological changes of stria vascularis, blood labyrinth barrier (BLB) permeability and expression of apoptotic proteins were observed in vivo by using the auditory brainstem response (ABR) test, HE staining, Evans blue staining, immunohistochemistry, western blotting, etc...
March 13, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38490045/platinum-iv-drugs-with-cannabidiol-inducing-mitochondrial-dysfunction-and-synergistically-enhancing-anti-tumor-effects
#11
JOURNAL ARTICLE
Tangli Wei, Lihua Chen, Pengmin Shi, Changli Wang, Yusheng Peng, Jing Yang, Xiali Liao, Bo Yang, Chuanzhu Gao
Chemotherapy resistance is an insurmountable problem in clinical anticancer therapy. Although Oxaliplatin is an effective chemotherapeutic agent for the treatment of colorectal cancer (CRC), it still suffers from serious toxicities as well as drug resistance. In this work, three Oxaliplatin tetravalent platinum prodrugs(O1-O3) and three novel mixed ammine/amine analogs(C1-C3) were constructed, introducing cannabidiol with anti-tumor activity in their axial position. All Pt(IV) prodrugs exhibited potent antitumor effects in a variety of tumor cell lines, especially in HCT-116 cells, where complex O3 showed strong inhibitory effects with the half maximal inhibitory concentrations (IC50 ) value of 6...
March 1, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38488992/interference-with-mthfd2-induces-ferroptosis-in-ovarian-cancer-cells-through-erk-signaling-to-suppress-tumor-malignant-progression
#12
JOURNAL ARTICLE
Xiaoliang Mo, Qianqian Liu, Kunling Liang, Yingxin Song
Ovarian cancer (OC) is a deadliest gynecological cancer with the highest mortality rate. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a crucial tumor-promoting factor, is over-expressed in several malignancies including OC. The present study aimed to explore the role and mechanisms of MTHFD2 in OC malignant progression. Thus, cell proliferation, cycling, apoptosis, migration, and invasion were evaluated by CCK-8 assay, EdU assay, flow cytometry, wound healing, transwell assay and western blotting. Additionally, glycolysis was assessed by measuring the level of glucose and lactate production, as well as the expressions of GLUT1, HK2 and PKM2...
March 15, 2024: Journal of Bioenergetics and Biomembranes
https://read.qxmd.com/read/38488434/improving-therapeutic-potential-in-breast-cancer-via-histone-deacetylase-inhibitor-loaded-nanofibrils
#13
JOURNAL ARTICLE
Praveetha Senthilkumar, Bhaskar Gogoi, Swati Smita Dhan, Ramesh Subramani, Charumathi Pushparaj, Ayyavu Mahesh
Epigenetic modifications play a significant role in cancer progression, making them potential targets for therapy. Histone deacetylase inhibitors have shown promise in inhibiting cancer cell growth, including in breast cancer (BC). In this research, we examined the potential of using suberoyl anilide hydroxamic acid (SAHA)-loaded β-lg nanofibrils as a drug delivery system for triple-negative BC cell lines. We assessed their impact on cell cycle progression, apoptosis, levels of reactive oxygen species, and mitochondrial membrane potential in cancer cells...
April 2024: Drug Development Research
https://read.qxmd.com/read/38488029/role-and-molecular-mechanisms-of-sglt2-inhibitors-in-pathological-cardiac-remodeling-review
#14
REVIEW
Bixian Chen, Jing Guo, Hongmei Ye, Xinyu Wang, Yufei Feng
Cardiovascular diseases are caused by pathological cardiac remodeling, which involves fibrosis, inflammation and cell dysfunction. This includes autophagy, apoptosis, oxidative stress, mitochondrial dysfunction, changes in energy metabolism, angiogenesis and dysregulation of signaling pathways. These changes in heart structure and/or function ultimately result in heart failure. In an effort to prevent this, multiple cardiovascular outcome trials have demonstrated the cardiac benefits of sodium‑glucose cotransporter type 2 inhibitors (SGLT2is), hypoglycemic drugs initially designed to treat type 2 diabetes mellitus...
May 2024: Molecular Medicine Reports
https://read.qxmd.com/read/38486744/intraventricular-dimethyl-sulfoxide-dmso-induces-hydrocephalus-in-a-dose-dependent-pattern
#15
JOURNAL ARTICLE
Leandro Castaneyra-Ruiz, Jenna Ledbetter, Seunghyun Lee, Anthony Rangel, Evelyn Torres, Bianca Romero, Michael Muhonen
INTRODUCTION: Dimethyl sulfoxide (DMSO), a widely utilized solvent in the medical industry, has been associated with various adverse effects, even at low concentrations, including damage to mitochondrial integrity, altered membrane potentials, caspase activation, and apoptosis. Notably, therapeutic molecules for central nervous system treatments, such as embolic agents or some chemotherapy drugs that are dissolved in DMSO, have been associated with hydrocephalus as a secondary complication...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38486493/role-of-pten-induced-protein-kinase-1-as-a-mitochondrial-dysfunction-regulator-in-cardiovascular-disease-pathogenesis
#16
REVIEW
Jun Gyo Gwon, Seung Min Lee
Cardiovascular disease (CVD) remains a global health challenge, primarily due to atherosclerosis, which leads to conditions such as coronary artery disease, cerebrovascular disease, and peripheral arterial disease. Mitochondrial dysfunction initiates endothelial dysfunction, a key contributor to CVD pathogenesis, as well as triggers the accumulation of reactive oxygen species (ROS), energy stress, and cell death in endothelial cells, which are crucial for atherosclerosis development. This review explores the role of PTEN-induced protein kinase 1 (PINK1) in mitochondrial quality control, focusing on its significance in cardiovascular health...
March 15, 2024: Vascular Specialist International
https://read.qxmd.com/read/38486414/modulating-oxidative-stress-apoptosis-and-mitochondrial-dysfunctions-on-cardiotoxicity-induced-by-aluminum-phosphide-pesticide-using-resveratrol
#17
JOURNAL ARTICLE
Deema K Sabir, Abeer Al-Masri, Munirah F Aldayel, Abeer A Sharaf
The agricultural fumigant pesticide aluminum phosphide (AlP) is cardiotoxic. Water causes AlP to emit phosphine gas, a cardiac toxin that affects heart function and causes cardiogenic shock. AlP poisoning's high fatality rate is due to cardiotoxicity. This study examines how resveratrol reduces oxidative stress, mitochondrial activity, and apoptosis in human cardiac myocyte (HCM) cells. After determining the optimal doses of resveratrol using the MTT test, HCM cells were subjected to a 24-hour treatment of resveratrol following exposure to AlP (2...
March 14, 2024: Toxicology Mechanisms and Methods
https://read.qxmd.com/read/38486411/novel-furan-chalcone-modulates-phd-2-induction-to-impart-antineoplastic-effect-in-mammary-gland-carcinoma
#18
JOURNAL ARTICLE
Shubham Rastogi, Mohd Nazam Ansari, Abdulaziz S Saeedan, Sunil Kumar Singh, Alok Mukerjee, Gaurav Kaithwas
Normoxic inactivation of prolyl hydroxylase-2 (PHD-2) in tumour microenvironment paves the way for cancer cells to thrive under the influence of HIF-1α and NF-κB. Henceforth, the present study is aimed to identify small molecule activators of PHD-2. A virtual screening was conducted on a library consisting of 265,242 chemical compounds, with the objective of identifying molecules that exhibit structural similarities to the furan chalcone scaffold. Further, PHD-2 activation potential of screened compound was determined using in vitro 2-oxoglutarate assay...
April 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38485921/network-pharmacology-prediction-molecular-docking-and-in-vitro-experiment-explored-the-potential-mechanism-of-gaoyuan-an-capsule-in-improving-hypoxia-tolerance
#19
JOURNAL ARTICLE
Tianbo Jin, Xiaoli Liu, Yuhe Wang, Yijin Qi, Xuemei Li, Li Wang, Xue He
BACKGROUND: Tibetan medicine Gaoyuan'an capsule (GYAC) is widely used to prevent pulmonary edema at high altitude, but the specific mechanism has not been explored. In this study, we analyzed the mechanism of GYAC in hypoxia tolerance, and provided a new idea for the prevention and treatment of altitude disease. METHODS: The effective components and corresponding targets of GYAC were screened out by the Chinese herbal medicine network database, and the key targets of hypoxia tolerance were retrieved by Genecards, OMIM and PubMed database...
March 14, 2024: Pharmacogenomics Journal
https://read.qxmd.com/read/38485716/imeglimin-mitigates-the-accumulation-of-dysfunctional-mitochondria-to-restore-insulin-secretion-and-suppress-apoptosis-of-pancreatic-%C3%AE-cells-from-db-db-mice
#20
JOURNAL ARTICLE
Kyota Aoyagi, Chiyono Nishiwaki, Yoko Nakamichi, Shun-Ichi Yamashita, Tomotake Kanki, Mica Ohara-Imaizumi
Mitochondrial dysfunction in pancreatic β-cells leads to impaired glucose-stimulated insulin secretion (GSIS) and type 2 diabetes (T2D), highlighting the importance of autophagic elimination of dysfunctional mitochondria (mitophagy) in mitochondrial quality control (mQC). Imeglimin, a new oral anti-diabetic drug that improves hyperglycemia and GSIS, may enhance mitochondrial activity. However, chronic imeglimin treatment's effects on mQC in diabetic β-cells are unknown. Here, we compared imeglimin, structurally similar anti-diabetic drug metformin, and insulin for their effects on clearance of dysfunctional mitochondria through mitophagy in pancreatic β-cells from diabetic model db/db mice and mitophagy reporter (CMMR) mice...
March 14, 2024: Scientific Reports
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