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Cancer vulvar

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https://www.readbyqxmd.com/read/28930828/18f-fdg-pet-ct-in-preoperative-staging-of-vulvar-cancer-patients-is-it-really-effective
#1
Cinzia Crivellaro, Priscilla Guglielmo, Elena De Ponti, Federica Elisei, Luca Guerra, Sonia Magni, Maria La Manna, Giampaolo Di Martino, Claudio Landoni, Alessandro Buda
The aim of this study was to assess the role of 18F-FDG PET/CT in preoperative staging of vulvar cancer patients.29 pts (69 years, range 51-88) with vulvar cancer (clinical apparent stage I-II), underwent preoperative FDG-PET/CT scan followed by radical vulvectomy and bilateral (or monolateral in case of tumor >2 cm from midline) inguinal lymphadenectomy ± sentinel node biopsy. PET/CT images were analyzed in consensus and correlated to histological findings according to a pt-based and a groin-based analyses...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28929201/pelvic-floor-disorders-in-women-with-gynecologic-malignancies-a-systematic-review
#2
REVIEW
Aparna S Ramaseshan, Jessica Felton, Dana Roque, Gautam Rao, Andrea G Shipper, Tatiana V D Sanses
INTRODUCTION AND HYPOTHESIS: Pelvic floor disorders (PFDs) negatively affect quality of life in the general population, and their prevalence in gynecologic cancer survivors has not been systematically described. This study aimed to determine the prevalence of PFDs in cancer survivors. We hypothesized that the prevalence of PFDs in the gynecologic cancer population would be higher than in the general female population. METHODS: We searched PubMed (1809 to present), EMBASE (1974 to present), and the Cochrane Central Register of Controlled Trials (CENTRAL) through May 2017...
September 19, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28928886/vulvar-cancer-in-china-epidemiological-features-and-risk-analysis
#3
Xue Xiao, Yi-Bo Meng, Peng Bai, Juan Zou, Ya Zhang, Tri M Bui Nguyen, Jian-Guo Xiao, Xue-Mei Gao, Bang-Fen Wen
Objective: Describe for the first time the clinical, epidemiological features of vulvar cancer in southwest China. Identify risk factors and provide reference for the prevention of vulvar cancer. Method: We retrospectively analyzed 885 patients admitted to the West China Second University Hospital for vulvar diseases between 2006 and 2016. Vulvar cancer patients with previously diagnosed vulvar nonneoplastic epithelial disorders (n=132) were analyzed and compared to those without prior history of vulvar nonneoplastic epithelial disorders (n=219)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28918994/meaningful-methods-for-increasing-human-papillomavirus-vaccination-rates-an%C3%A2-integrative-literature-review
#4
Kristin Vollrath, Susan Thul, Jenny Holcombe
Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States and is a well-known cause of oropharyngeal, cervical, vaginal, vulvar, penile, and anal cancers. Despite the proven efficacy of the HPV vaccine, vaccination rates remain persistently low. Much literature has focused on attitudes toward the HPV vaccine; however, researchers have also investigated strategies clinicians can use to improve vaccination attitudes and acceptance. Such strategies include provider education, vaccine reminder/recall, and chart audit and feedback...
September 14, 2017: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/28913152/early-vulvar-and-umbilical-incisional-scar-recurrence-of-cervical-squamous-cell-carcinoma-earlier-than-usually-expected
#5
Hüseyin Çağlayan Özcan, Aynur Mustafa, Zehra Bozdağ, Seyhun Sucu, Mete Gürol Uğur, Özcan Balat
Cutaneous metastasis is considered as a hazardous condition depending on the mean survival around 9 months, which usually originates from cancers of the breast, lung, ovary, colon, and rarely from the cervix. The crucial prognostic factor of cutaneous metastasis depends on the period between the primary malignancy and cutaneous metastasis. We report two cases of the unusual presentation of squamous cell cancer of the cervix that developed vulvar and umbilical metastasis in the 5(th) month of primary treatment...
June 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28899974/genomic-characterisation-of-vulvar-pre-cancers-identifies-distinct-molecular-subtypes-with-prognostic-significance
#6
Linda Nooij, Natalja Ter Haar, Dina Ruano, Natalia Rakislova, Vincent T H B M Smit, J Baptist M Z Trimbos, Jaume Ordi, Mariette Ie van Poelgeest, Tjalling Bosse, Tom van Wezel
Background Vulvar cancer (VC) can be sub-classified by human papilloma virus (HPV) status. HPV negative VCs frequently harbour TP53 mutations, however in-depth analysis of other potential molecular genetic alterations is lacking. We comprehensively assessed somatic mutations in a large series of vulvar (pre)cancers. Methods We performed targeted next generation sequencing (17 genes), p53 immunohistochemistry and HPV-testing on 36 VC and 82 precursors (sequencing cohort). Subsequently, the prognostic significance of the three subtypes identified in the sequencing cohort was assessed in a series of 236 VC-patients (follow-up cohort)...
September 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28899625/cost-effectiveness-of-hpv-vaccination-in-the-context-of-high-cervical-cancer-incidence-and-low-screening-coverage
#7
Triin Võrno, Katrin Lutsar, Anneli Uusküla, Lee Padrik, Terje Raud, Rainer Reile, Oliver Nahkur, Raul-Allan Kiivet
BACKGROUND: Estonia has high cervical cancer incidence and low screening coverage. We modelled the impact of population-based bivalent, quadrivalent or nonavalent HPV vaccination alongside cervical cancer screening. METHODS: A Markov cohort model of the natural history of HPV infection was used to assess the cost-effectiveness of vaccinating a cohort of 12-year-old girls with bivalent, quadrivalent or nonavalent vaccine in two doses in a national, school-based vaccination programme...
September 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28886907/final-efficacy-immunogenicity-and-safety-analyses-of-a-nine-valent-human-papillomavirus-vaccine-in-women-aged-16-26-years-a-randomised-double-blind-trial
#8
Warner K Huh, Elmar A Joura, Anna R Giuliano, Ole-Erik Iversen, Rosires Pereira de Andrade, Kevin A Ault, Deborah Bartholomew, Ramon M Cestero, Edison N Fedrizzi, Angelica L Hirschberg, Marie-Hélène Mayrand, Angela Maria Ruiz-Sternberg, Jack T Stapleton, Dorothy J Wiley, Alex Ferenczy, Robert Kurman, Brigitte M Ronnett, Mark H Stoler, Jack Cuzick, Suzanne M Garland, Susanne K Kjaer, Oliver M Bautista, Richard Haupt, Erin Moeller, Michael Ritter, Christine C Roberts, Christine Shields, Alain Luxembourg
BACKGROUND: Primary analyses of a study in young women aged 16-26 years showed efficacy of the nine-valent human papillomavirus (9vHPV; HPV 6, 11, 16, 18, 31, 33, 45, 52, and 58) vaccine against infections and disease related to HPV 31, 33, 45, 52, and 58, and non-inferior HPV 6, 11, 16, and 18 antibody responses when compared with quadrivalent HPV (qHPV; HPV 6, 11, 16, and 18) vaccine. We aimed to report efficacy of the 9vHPV vaccine for up to 6 years following first administration and antibody responses over 5 years...
September 5, 2017: Lancet
https://www.readbyqxmd.com/read/28885273/a-comparative-study-of-video-endoscopic-inguinal-lymphadenectomy-and-conventional-open-inguinal-lymphadenectomy-for-treating-vulvar-cancer
#9
Menglei Zhang, Limei Chen, Xuyin Zhang, Jingxin Ding, Keqin Hua
OBJECTIVE: This study aims to compare the complications, oncological outcomes, cosmetic satisfaction, and quality of life experienced by women with vulvar cancer undergoing video endoscopic inguinal lymphadenectomy (VEIL) versus conventional open inguinal lymphadenectomy (COIL). PATIENTS AND METHODS: Forty-eight consecutive patients with vulvar cancer who underwent COIL (n = 27) or VEIL (n = 21) at the Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China between 2003 and 2016 were included in this retrospective cohort study...
September 6, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28884278/hpv-prevalence-in-vulvar-cancer-in-austria
#10
Sophie Pils, Lisa Gensthaler, Laia Alemany, Reinhard Horvat, Silvia de Sanjosé, Elmar A Joura
BACKGROUND: Even if vulvar cancer is not common, over one hundred women are affected in Austria per year. There is strong evidence that basaloid and warty variants are associated with types of human papillomavirus (HPV). METHODS: The aim of this study is to analyze the types of HPV in vulvar cancer in Austria. This cross-sectional period-prevalence international collaborative study on archival specimens was performed in cooperation with the Institut Catalan di Oncologia in Barcelona, Spain...
September 7, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28881312/lc-ms-ms-assay-for-the-quantitation-of-the-ribonucleotide-reductase-inhibitor-triapine-in-human-plasma
#11
Julia Matsumoto, Brian F Kiesel, Robert A Parise, Jianxia Guo, Sarah Taylor, Marilyn Huang, Julie L Eiseman, S Percy Ivy, Charles Kunos, Edward Chu, Jan H Beumer
The ribonucleotide reductase inhibitor and radiosensitizer triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP), NSC 663249) is clinically being evaluated via the intravenous (IV) route for the treatment of cervical and vulvar cancer in combination with primary cisplatin chemoradiation. The need for a 2-h infusion and frequent administration of triapine is logistically challenging, prompting us to pursue oral (PO) administration. In support of the clinical trial investigating oral triapine in combination with chemoradiation, we developed and validated a novel LC-MS/MS assay for the quantification of triapine in 50μL human plasma...
August 31, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28877932/detection-and-genomic-characterization-of-a-mammary-like-adenocarcinoma
#12
Jasleen K Grewal, Peter Eirew, Martin Jones, Kenrry Chiu, Basile Tessier-Cloutier, Anthony N Karnezis, Aly Karsan, Andy Mungall, Chen Zhou, Stephen Yip, Anna V Tinker, Janessa Laskin, Marco Marra, Steven J M Jones
Whole-genome and transcriptome sequencing were performed to identify potential therapeutic strategies in the absence of viable treatment options for a patient initially diagnosed with vulvar adenocarcinoma. Genomic events were prioritized by comparison against variant distributions in the TCGA pan-cancer dataset, and complemented with detailed transcriptome sequencing and copy number analysis. These findings were considered against published scientific literature in order to evaluate the functional effects of potentially relevant genomic events...
September 6, 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/28862603/-the-activity-of-redox-regulatory-systems-in-the-primary-and-recurrence-tumors-in-vulvar-cancer
#13
E I Surikova, I A Goroshinskaya, E M Frantsiyants, E V Shalashnaja, G A Nerodo, I V Neskubina, P S Kachesova, L A Nemashkalova, A V Chudilova
The activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione reductase (GR), glutathione transferase (GST), the content of reduced glutathione (GSH) and malondialdehyde (MDA) were investigated in the samples of the tumor, peritumoral zone and healthy tissue, taken at the line of resection, were obtained from 14 patients with primary squamous cell carcinoma of the vulva, and 13 patients with local recurrence appeared in the period from 3 months to 7 years. by conventional spectrophotometric methods...
July 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/28843233/increasing-awareness-of-gynecologic-cancer-risks-and-symptoms-among-asian-native-hawaiian-and-pacific-islander-women-in-the-us-associated-pacific-island-jurisdictions
#14
Daniel Novinson, Mary Puckett, Julie Townsend, Martina Reichhardt, Aileen Tareg, Jennifer Palemar, Ritchie Wichilib, Sherri L Stewart
Background: Gynecologic cancers are common among Asian/Native Hawaiian/Pacific Islander (A/NH/PI) women. Prevention is important in United States associated Pacific Island jurisdictions (USAPIJ) because there are limited resources to treat cancer. The objective of this study was to educate A/NH/PI women and providers about evidence-based interventions to prevent and control gynecologic cancers in Yap, one of four major islands comprising the Federated States of Micronesia (FSM). This was done through a partnership between Inside Knowledge: Get The Facts About Gynecologic Cancer national campaign and the Yap comprehensive cancer control program, both funded by the Center for Disease Control and Prevention (CDC)...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28807366/prospective-screening-with-the-validated-opioid-risk-tool-demonstrates-gynecologic-oncology-patients-are-at-low-risk-for-opioid-misuse
#15
Christine Garcia, Carolyn Lefkowits, Elizabeth Pelkofski, Leslie Blackhall, Linda R Duska
OBJECTIVE: To characterize risk for opioid misuse among gynecologic oncology patients. METHODS: The Opioid Risk Tool (ORT), a validated screen for opioid misuse risk, was administered to a convenience sample of patients with gynecologic cancer receiving opioid prescriptions in gynecologic oncology or palliative care clinics from January 2012-June 2016. Demographic and clinical information was abstracted on chart review. The primary outcome was ORT risk level (low vs...
August 11, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28803217/accurate-model-based-segmentation-of-gynecologic-brachytherapy-catheter-collections-in-mri-images
#16
Andre Mastmeyer, Guillaume Pernelle, Ruibin Ma, Lauren Barber, Tina Kapur
The gynecological cancer mortality rate, including cervical, ovarian, vaginal and vulvar cancers, is more than 20,000 annually in the US alone. In many countries, including the US, external-beam radiotherapy followed by high dose rate brachytherapy is the standard-of-care. The superior ability of MR to visualize soft tissue has led to an increase in its usage in planning and delivering brachytherapy treatment. A technical challenge associated with the use of MRI imaging for brachytherapy, in contrast to that of CT imaging, is the visualization of catheters that are used to place radiation sources into cancerous tissue...
July 18, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28799431/vulvar-cancer-in-germany-increase-in-incidence-and-change-in-tumour-biological-characteristics-from-1974-to-2013
#17
Bernd Holleczek, Jalid Sehouli, Jana Barinoff
BACKGROUND: The incidence of vulvar cancer in Germany is increasing. Moreover, gynaecological oncologists reported observing increasing numbers of women presenting with small tumours. The aim of the present study is to validate this observation on a population level and to extend available incidence data. MATERIAL AND METHODS: Data from the population-based Saarland Cancer Registry were used and included 1136 women diagnosed with invasive vulvar cancer (ICD-9 codes: 181...
August 11, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28797698/prognostic-value-of-lymph-node-ratio-and-number-of-positive-inguinal-nodes-in-patients-with-vulvar-cancer
#18
Stephan Polterauer, Richard Schwameis, Christoph Grimm, Ronalds Macuks, Sara Iacoponi, Kamil Zalewski, Ignacio Zapardiel
OBJECTIVE: To estimate the prognostic significance of lymph node ratio and number of positive nodes in vulvar cancer patients. METHODS: This international multicenter retrospective study included patients diagnosed with vulvar cancer treated with inguinal lymphadenectomy. Lymph node ratio (LNR) is the ratio of the number of positive lymph nodes (LN) to the number of removed LN. Patients were stratified into risk groups according to LNR. LNR was correlated with clinical-pathological parameters...
August 7, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28789851/antibody-persistence-and-evidence-of-immune-memory-at-5years-following-administration-of-the-9-valent-hpv-vaccine
#19
Ana Guevara, Robinson Cabello, Linn Woelber, Edson Duarte Moreira, Elmar Joura, Olaf Reich, Christine Shields, Misoo C Ellison, Amita Joshi, Alain Luxembourg
BACKGROUND: The 9-valent HPV (9vHPV) vaccine was developed to prevent infection and disease related to 9 HPV types (HPV6/11/16/18/31/33/45/52/58) which cause approximately 90% of cervical cancers, HPV-related vulvar, vaginal and anal cancers, and genital warts worldwide. In a pivotal efficacy study, the 9vHPV vaccine prevented infection and disease due to the 9 vaccine types. Duration of protection remains to be determined. Vaccines that induce long-term protection are generally characterized by the generation of immune memory...
August 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28763369/sentinel-lymph-node-biopsy-in-the-management-of-vulvar-carcinoma-an-evidence-based-insight
#20
Mark R Brincat, Yves Muscat Baron
OBJECTIVE: Lymph node metastasis has been shown to represent the most significant prognostic factor in vulvar carcinoma. Because only 25% to 35% of patients with early stage disease have lymph node metastases, a significant 65% to 75% possibly do not benefit from elective inguinofemoral lymphadenectomy considering the related morbidities of wound infection, breakdown, and lower limb lymphedema. This review article aims to present and summarize the evidence available with regard to sentinel lymph node (SLN)-guided management of vulvar carcinoma...
August 1, 2017: International Journal of Gynecological Cancer
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