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https://www.readbyqxmd.com/read/29475177/impact-of-pre-procedural-dual-antiplatelet-therapy-on-periprocedural-myocardial-infarction-in-patients-undergoing-percutaneous-coronary-interventions-with-adjunctive-tirofiban
#1
Monica Verdoia, Patrizia Pergolini, Lucia Barbieri, Roberta Rolla, Matteo Nardin, Federica Negro, Harry Suryapranata, Giuseppe De Luca
BACKGROUND: Recent trials have failed to demonstrate any clinical benefit from pre-treatment with dual antiplatelet therapy (DAPT) in patients undergoing percutaneous coronary interventions, (PCI), even in the setting of acute coronary syndrome. However, suboptimal platelet inhibition during (PCI) has been shown to enhance the risk of acute ischemic complications, such as stent thrombosis and periprocedural myocardial infarction (PMI), thus raising the attention on the potential advantages of adjunctive glycoprotein IIbIIIa inhibitors to obviate to the delayed onset of action of oral antiplatelet drugs...
February 15, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29474830/erythema-nodosum-leprosum-update-and-challenges-on-the-treatment-of-a-neglected-condition
#2
REVIEW
Perpétua do Socorro Silva Costa, Lucas Rosa Fraga, Thayne Woycinck Kowalski, Egon Luiz Rodrigues Daxbacher, Lavínia Schuler-Faccini, Fernanda Sales Luiz Vianna
Erythema Nodosum Leprosum (ENL) occurs due to the immunological complication of multibacillary leprosy and is characterized by painful nodules and systemic compromising. It is usually recurrent and/or chronic and has both physical and economic impact on the patient, being a very important cause of disability. In addition, ENL is a major health problem in countries where leprosy is endemic. Therefore, adequate control of this condition is important. The management of ENL aims to control acute inflammation and neuritis and prevent the onset of new episodes...
February 20, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29474668/real-time-left-ventricular-pressure-volume-loops-during-percutaneous-central-arteriovenous-anastomosis
#3
Sebastian Ewen, Lucas Lauder, Michael Böhm, Felix Mahfoud
No abstract text is available yet for this article.
February 20, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29474318/fibroblastic-malignant-peripheral-nerve-sheath-tumour-of-the-uterine-cervix-report-of-a-case-and-literature-review-with-emphasis-on-possible-differential-diagnosis
#4
Valentina Sangiorgio, Vanna Zanagnolo, Giovanni Aletti, Luca Bocciolone, Simone Bruni, Fabio Landoni, Nicoletta Colombo, Angelo Maggioni, Enzo Ricciardi
Cervical sarcomas are rare neoplasms, accounting for <1% of all cervical malignancies and characterized by an aggressive course despite radical excision. We report the clinical and microscopic features of a spindle cell sarcoma arising as a polypoid endocervical mass in a 45-yr-old woman. The neoplasm was characterized by a monotonous, mildly atypical proliferation of spindle cells, displaying a fibrosarcoma-like parallel pattern of highly dense fascicles, growing under the cervical epithelium. Mitotic activity was conspicuous, with up to 40 mitoses per 10 HPF...
February 22, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29474110/chronic-azithromycin-use-in-cystic-fibrosis-and-risk-of-treatment-emergent-respiratory-pathogens
#5
Jonathan D Cogen, Frankline Onchiri, Julia Emerson, Ronald L Gibson, Lucas R Hoffman, David P Nichols, Margaret Rosenfeld
RATIONALE: Azithromycin has been shown to improve lung function and reduce the number of pulmonary exacerbations in cystic fibrosis patients. Concerns remain, however, regarding the potential emergence of treatment-related respiratory pathogens. OBJECTIVES: To determine if chronic azithromycin use (defined as thrice weekly administration) is associated with increased rates of detection of eight specific respiratory pathogens. METHODS: We performed a new-user, propensity-score matched retrospective cohort study utilizing data from the Cystic Fibrosis Foundation Patient Registry...
February 23, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29474062/heating-rate-of-light-absorbing-aerosols-time-resolved-measurements-the-role-of-clouds-and-source-identification
#6
Luca Ferrero, Grisa Mocnik, Sergio Cogliati, Asta Gregoric, Roberto Colombo, Ezio Bolzacchini
Light Absorbing Aerosols (LAA) absorb sunlight and heat the atmosphere. This work presents a novel methodology to experimentally quantify the heating rate (HR) induced by LAA into an atmospheric layer. Multi-wavelength aerosol absorption measurements were coupled with spectral measurements of the direct, diffuse and surface reflected radiation to obtain highly-time resolved measurements of HR apportioned in the context of LAA species (Black Carbon, BC; Brown Carbon, BrC; dust), sources (fossil fuel, FF; and biomass burning, BB), and as a function of cloudiness...
February 23, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29473778/assessment-of-the-praxis-circuit-in-glioma-surgery-to-reduce-the-incidence-of-postoperative-and-long-term-apraxia-a-new-intraoperative-test
#7
Marco Rossi, Luca Fornia, Guglielmo Puglisi, Antonella Leonetti, Gianmarco Zuccon, Enrica Fava, Daniela Milani, Alessandra Casarotti, Marco Riva, Federico Pessina, Gabriella Cerri, Lorenzo Bello
OBJECTIVE Apraxia is a cognitive-motor deficit affecting the execution of skilled movements, termed praxis gestures, in the absence of primary sensory or motor disorders. In patients affected by stroke, apraxia is associated with lesions of the lateral parietofrontal stream, connecting the posterior parietal areas with the ventrolateral premotor area and subserving sensory-motor integration for the hand movements. In the neurosurgical literature to date, there are few reports regarding the incidence of apraxia after glioma surgery...
February 23, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29473467/checkpoint-inhibitors-raising-the-bar-also-in-brain-metastases-from-non-small-cell-lung-cancer
#8
Sabrina Rossi, Giovanna Finocchiaro, Silvia Marchetti, Luca Toschi, Armando Santoro
Despite efforts, brain metastases (BM) remain a critical issue in the management of patients affected by non-small-cell lung cancer (NSCLC). To date, radiotherapy is still considered the gold standard treatment; on the other hand, systemic chemotherapeutical agents are not so often an effective therapy for BM, whereas targeted agents in oncogene-addicted disease have shown a good activity also on BM. Anti-programmed death-1/programmed death ligand-1 agents represent a new valid therapeutic strategy for NSCLC as well as for several tumor types, but their efficacy on patients with BM is still unclear mainly due to the strict selection criteria adopted in clinical trials...
April 2018: Immunotherapy
https://www.readbyqxmd.com/read/29473430/lymphomatoid-granulomatosis-and-large-granular-lymphocyte-leukemia-a-rare-association-of-two-lymphoproliferative-disorders
#9
Giulia De Luca, Stefania Trasarti, Luisa Bizzoni, Ilaria Del Giudice, Irene Della Starza, Maria Stefania De Propris, Giuseppe Gentile, Francesca Mancini, Sara Mantovani, Luigi Petrucci, Valentina Tabanelli, Anna Guarini, Marco Vignetti, Robin Foà
No abstract text is available yet for this article.
February 23, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29473425/characterisation-of-nutraceutical-compounds-from-different-parts-of-particular-species-of-citrus-sinensis-ovale-calabrese-by-uhplc-uv-esi-hrms
#10
Rita Celano, Luca Campone, Imma Pagano, Sonia Carabetta, Rosa Di Sanzo, Luca Rastrelli, Anna Lisa Piccinelli, Mariateresa Russo
Consumers are aware of diet causing health problems and therefore there is an increased demand for natural ingredients that are expected to be safe and health-promoting. Many of these compounds belong to the class of flavonoids and can be divided into these five groups: flavanones, flavones, flavonols, flavanols, isoflavones and anthocyanidins. Extracts from citrus fruits are usually used as functional ingredients for several products. The aim of this paper was to develop an UHPLC-UV-ESI-HRMS method to define the metabolite profile of different parts of citrus fruit, of a particular cultivar called 'Ovale Calabrese', and in its main by-products...
February 23, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29473383/prevalence-of-phimosis-and-foreskin-sliding-abnormalities-in-male-adolescents-and-their-correlation-with-later-onset-of-first-sexual-intercourse
#11
Giuseppe La Pera, Francesco De Luca, Attilio Guerani, Alessandro Palmieri, Giorgio Franco
INTRODUCTION AND OBJECTIVES: The aim of the study is to evaluate the prevalence of andrological abnormalities, such as phimosis and foreskin sliding abnormalities among male adolescents, and if these might interfere with sexuality, leading to a later onset of sexual experiences. MATERIAL AND METHODS: Between April and May 2015 a prevention campaign in andrology was conducted in an area surrounding Rome, Ostia and the Ladispoli area, among 15-19 year-old students...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473376/can-re-cturbt-be-useful-in-pt1hg-disease-as-a-risk-indicator-of-recurrence-and-progression-a-single-centre-experience
#12
Roberto Giulianelli, Barbara Cristina Gentile, Gabriella Mirabile, Luca Albanesi, Paola Tariciotti, Giorgio Rizzo, Maurizio Buscarini, Mauro Vermiglio
INTRODUCTION: Understaging after initial transurethral resection is common in patients with high-risk non muscle infiltrating bladder cancer (NMIBC) and can delay accurate diagnosis and definitive treatment. The rate of upstaging from T1 to T2 disease after repeated transurethral resection ranges from 0 to 28%, although the rate of upstaging may be even higher up to 49% when muscularis propria is absent in the first specimen. A restaging classic transurethral resection of bladder tumour (re-cTURBT) is the better predictor of early stage progression...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473372/risk-factors-for-benign-prostatic-enlargement-the-role-of-lifestyle-habits-at-younger-age-the-controllati2017-initiative-study-group
#13
Vincenzo Mirone, Giuseppe Carrieri, Giuseppe Morgia, Luca Carmignani, Giuseppe Vespasiani, Fabio Parazzini, Walter Artibani
OBJECTIVE: The risk factors for benign prostatic enlargement (BPE) are not well understood and particularly few data are available from Italian population. MATERIALS AND METHODS: This was an observational cross sectional study aimed to examine the association between several risk factors and BPE. During the "#Controllati2017" initiative, men aged 18 years or more were invited to attend participating urologic centers for a free of charge visit for counseling about urologic or andrologic conditions...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29472933/leucine-rich-repeat-kinase-2-controls-the-ca-2-nuclear-factor-of-activated-t-cells-il-2-pathway-during-aspergillus-non-canonical-autophagy-in-dendritic-cells
#14
Alicia Yoke Wei Wong, Vasilis Oikonomou, Giuseppe Paolicelli, Antonella De Luca, Marilena Pariano, Jan Fric, Hock Soon Tay, Paola Ricciardi-Castagnoli, Teresa Zelante
The Parkinson's disease-associated protein, Leucine-rich repeat kinase 2 (LRRK2), a known negative regulator of nuclear factor of activated T cells (NFAT), is expressed in myeloid cells such as macrophages and dendritic cells (DCs) and is involved in the host immune response against pathogens. Since, the Ca2+ /NFAT/IL-2 axis has been previously found to regulate DC response to the fungus Aspergillus , we have investigated the role played by the kinase LRRK2 during fungal infection. Mechanistically, we found that in the early stages of the non-canonical autophagic response of DCs to the germinated spores of Aspergillus , LRRK2 undergoes progressive degradation and regulates NFAT translocation from the cytoplasm to the nucleus...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29472837/spike-timing-dependent-plasticity-in-unipolar-silicon-oxide-rram-devices
#15
Konstantin Zarudnyi, Adnan Mehonic, Luca Montesi, Mark Buckwell, Stephen Hudziak, Anthony J Kenyon
Resistance switching, or Resistive RAM (RRAM) devices show considerable potential for application in hardware spiking neural networks (neuro-inspired computing) by mimicking some of the behavior of biological synapses, and hence enabling non-von Neumann computer architectures. Spike-timing dependent plasticity (STDP) is one such behavior, and one example of several classes of plasticity that are being examined with the aim of finding suitable algorithms for application in many computing tasks such as coincidence detection, classification and image recognition...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29472740/physiological-and-performance-changes-in-national-and-international-judo-athletes-during-block-periodization-training
#16
Lucas Marques, Emerson Franchini, Gustavo Drago, Marcelo S Aoki, Alexandre Moreira
Block periodization (BP) has been proposed as an alternative approach for application in the context of high-level sports. Despite its growing acceptance, there is no empirical evidence of BP adoption in high-level judo athletes. Therefore, this study aimed to compare the maximal strength, muscle power, judo-specific performances, and hormonal concentration changes of state/national level (NG) and international level (IG) judo athletes subjected to BP. Twenty-one elite judo athletes (international level = 10; 21...
December 2017: Biology of Sport
https://www.readbyqxmd.com/read/29472719/epigenetic-heterogeneity-affects-the-risk-of-relapse-in-children-with-t-8-21-runx1-runx1t1-rearranged-aml
#17
Matteo Zampini, Claudia Tregnago, Valeria Bisio, Luca Simula, Giulia Borella, Elena Manara, Carlo Zanon, Francesca Zonta, Valentina Serafin, Benedetta Accordi, Silvia Campello, Barbara Buldini, Andrea Pession, Franco Locatelli, Giuseppe Basso, Martina Pigazzi
The somatic translocation t(8;21)(q22;q22)/RUNX1-RUNX1T1 is one of the most frequent rearrangements found in children with standard-risk acute myeloid leukemia (AML). Despite the favorable prognostic role of this aberration, we recently observed a higher than expected frequency of relapse. Here, we employed an integrated high-throughput approach aimed at identifying new biological features predicting relapse among 34 t(8;21)-rearranged patients. We found that the DNA methylation status of patients who suffered from relapse was peculiarly different from that of children maintaining complete remission...
February 2, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29472629/indication-to-pelvic-lymph-nodes-dissection-for-prostate-cancer-the-role-of-multiparametric-magnetic-resonance-imaging-when-the-risk-of-lymph-nodes-invasion-according-to-briganti-updated-nomogram-is-5
#18
Francesco Porpiglia, Matteo Manfredi, Fabrizio Mele, Riccardo Bertolo, Enrico Bollito, Dario Gned, Agostino De Pascale, Filippo Russo, Roberto Passera, Cristian Fiori, Stefano De Luca
BACKGROUND: The Briganti updated nomogram (BN) is the most popular predictive model aiming to predict the presence of lymph node invasion (LNI) in patients with prostate cancer (PCa), but it lacks information obtained by preoperative imaging. The primary aim of the study was to evaluate the role of multiparametric prostate magnetic resonance imaging (mp-MRI) in the indication to perform pelvic lymph nodes dissection (PLND) or not in patients with risk of LNI according to BN below 5%. METHODS: Since March 2012 and September 2016, 310 patients who underwent a preoperative mp-MRI for staging purpose and subsequent robot-assisted extended PLND (RAEPLND) were retrospectively evaluated...
February 22, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29472554/reshaping-the-phonon-energy-landscape-of-nanocrystals-inside-a-terahertz-plasmonic-nanocavity
#19
Xin Jin, Andrea Cerea, Gabriele C Messina, Andrea Rovere, Riccardo Piccoli, Francesco De Donato, Francisco Palazon, Andrea Perucchi, Paola Di Pietro, Roberto Morandotti, Stefano Lupi, Francesco De Angelis, Mirko Prato, Andrea Toma, Luca Razzari
Phonons (quanta of collective vibrations) are a major source of energy dissipation and drive some of the most relevant properties of materials. In nanotechnology, phonons severely affect light emission and charge transport of nanodevices. While the phonon response is conventionally considered an inherent property of a nanomaterial, here we show that the dipole-active phonon resonance of semiconducting (CdS) nanocrystals can be drastically reshaped inside a terahertz plasmonic nanocavity, via the phonon strong coupling with the cavity vacuum electric field...
February 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29472527/hints-on-atgl-implications-in-cancer-beyond-bioenergetic-clues
#20
REVIEW
Rolando Vegliante, Luca Di Leo, Fabio Ciccarone, Maria Rosa Ciriolo
Among metabolic rearrangements occurring in cancer cells, lipid metabolism alteration has become a hallmark, aimed at sustaining accelerated proliferation. In particular, fatty acids (FAs) are dramatically required by cancer cells as signalling molecules and membrane building blocks, beyond bioenergetics. Along with de novo biosynthesis, free FAs derive from dietary sources or from intracellular lipid droplets, which represent the storage of triacylglycerols (TAGs). Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme of lipolysis, catalysing the first step of intracellular TAGs hydrolysis in several tissues...
February 22, 2018: Cell Death & Disease
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