keyword
MENU ▼
Read by QxMD icon Read
search

Lucas

keyword
https://www.readbyqxmd.com/read/29232671/predicting-trajectories-of-functional-decline-in-60-to-70-year-old-people
#1
Nini H Jonkman, Vieri Del Panta, Trynke Hoekstra, Marco Colpo, Natasja M van Schoor, Stefania Bandinelli, Luca Cattelani, Jorunn L Helbostad, Beatrix Vereijken, Mirjam Pijnappels, Andrea B Maier
BACKGROUND: Early identification of people at risk of functional decline is essential for delivering targeted preventive interventions. OBJECTIVE: The aim of this study is to identify and predict trajectories of functional decline over 9 years in males and females aged 60-70 years. METHODS: We included 403 community-dwelling participants from the InCHIANTI study and 395 from the LASA study aged 60-70 years at baseline, of whom the majority reported no functional decline at baseline (median 0, interquartile range 0-1)...
December 13, 2017: Gerontology
https://www.readbyqxmd.com/read/29232662/a-multicenter-clinical-evaluation-of-data-logging-in-cochlear-implant-recipients-using-automated-scene-classification-technologies
#2
Eliana Cristofari, Domenico Cuda, Alessandro Martini, Francesca Forli, Diego Zanetti, Diego Di Lisi, Pasquale Marsella, Daniele Marchioni, Vincenzo Vincenti, Claudia Aimoni, Gaetano Paludetti, Maria Grazia Barezzani, Carlo Antonio Leone, Nicola Quaranta, Marco Bianchedi, Livio Presutti, Antonio Della Volpe, Luca Oscar Redaelli de Zinis, Italo Cantore, Giuseppe Nicolò Frau, Eva Orzan, Francesco Galletti, Silvano Vitale, Ferdinando Raso, Maurizio Negri, Franco Trabalzini, Walter Livi, Lucia Oriella Piccioni, Giampietro Ricci, Paolo Malerba
Currently, there are no studies assessing everyday use of cochlear implant (CI) processors by recipients by means of objective tools. The Nucleus 6 sound processor features a data logging system capable of real-time recording of CI use in different acoustic environments and under various categories of loudness levels. In this study, we report data logged for the different scenes and different loudness levels of 1,366 CI patients, as recorded by SCAN. Monitoring device use in cochlear implant recipients of all ages provides important information about the listening conditions encountered in recipients' daily lives that may support counseling and assist in the further management of their device settings...
December 13, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/29232597/evaporation-effect-on-two-dimensional-wicking-in-porous-media
#3
Eric M Benner, Dimiter N Petsev
We analyze the effect of evaporation on expanding capillary flow for losses normal to the plane of a two-dimensional porous medium using the potential flow theory formulation of the Lucas-Washburn method. Evaporation induces a finite steady state liquid flux on capillary flows into fan-shaped domains which is significantly greater than the flux into media of constant cross section. We introduce the evaporation-capillary number, a new dimensionless quantity, which governs the frontal motion when multiplied by the scaled time...
December 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29232494/reconstructing-relational-information
#4
Kevin M Horecka, Michael Dulas, Hillary Schwarb, Heather Lucas, Melissa Duff, Neal J Cohen
Hippocampal involvement in learning and remembering relational information has an extensive history, often focusing specifically on spatial information. In humans, spatial reconstruction (SR) paradigms are a powerful tool for evaluating an individuals' spatial-relational memory. In SR tasks, participants study locations of items in space and subsequently reconstruct the studied display after a short delay. Previous work has revealed that patients with hippocampal damage are impaired both in overall placement accuracy as well as on a specific measure of relational memory efficacy, "swaps" (i...
December 12, 2017: Hippocampus
https://www.readbyqxmd.com/read/29232119/catalytic-mechanism-of-fungal-lytic-polysaccharide-monooxygenases-investigated-by-first-principles-calculations
#5
Luca Bertini, Raffaella Breglia, Matteo Lambrughi, Piercarlo Fantucci, Luca De Gioia, Marco Borsari, Marco Sola, Carlo Augusto Bortolotti, Maurizio Bruschi
Lytic polysaccharide monooxygenases (LPMOs) are Cu-containing enzymes that facilitate the degradation of recalcitrant polysaccharides by the oxidative cleavage of glycosidic bonds. They are gaining rapidly increasing attention as key players in biomass conversion, especially for the production of second-generation biofuels. Elucidation of the detailed mechanism of the LPMO reaction is a major step toward the assessment and optimization of LPMO efficacy in industrial biotechnology, paving the way to utilization of sustainable fuel sources...
December 12, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29231753/rates-of-insufficiency-and-deficiency-of-vitamin-d-levels-in-elite-professional-male-and-female-skiers-a-chronobiologic-approach
#6
Jacopo Antonino Vitale, Giovanni Lombardi, Luca Cavaleri, Rosa Graziani, Herbert Schoenhuber, Antonio La Torre, Giuseppe Banfi
Vitamin D is essential for the maintenance and promotion of musculoskeletal health, for the functioning of the immune, cardiovascular and reproductive systems, and its main action is to keep calcium and phosphate plasmatic physiological concentrations at intestinal, renal and bony level. Vitamin D affects several parameters related to physical performance too and a particularly high percentage of vitamin D insufficiency and deficiency in professional athletes has been observed. Several variables are able to impair the synthesis of 25(OH)D in athletes, specifically both genetic and environmental factors, but the most probable explanation for the deficient/insufficient vitamin D levels is the insufficient ultraviolet B light (UVB) exposure during winter...
December 12, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29231174/the-influence-of-substrate-roughness-patterning-curvature-and-compliance-in-peeling-problems
#7
Lucas Brely, Federico Bosia, Nicola M Pugno
Biological adhesion, in particular the mechanisms by which animals and plants "stick" to surfaces has been widely studied in recent years, and some of the structural principles have been successfully applied to bioinspired adhesives. However, modelling of adhesion such as in single or multiple peeling theories, have in most cases been limited to ideal cases and due consideration of the role of substrate geometry and mechanical properties has been limited. In this paper, we propose a numerical model to evaluate these effects, including substrate roughness, patterning, curvature and deformability...
December 12, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/29230946/direct-hplc-separation-of-carnosine-enantiomers-with-two-chiral-stationaryn-phases-based-on-penicillamine-and-teicoplanin-derivatives
#8
Laura Fumagalli, Lucia Pucciarini, Luca Regazzoni, Ettore Gilardoni, Marina Carini, Giulio Vistoli, Giancarlo Aldini, Roccardo Sardella
Carnosine is present in high concentrations in specific human tissues such as the skeletal muscle, and among its biological functions, the remarkable scavenging activity towards reactive carbonyl species is noteworthy. Although the two enantiomers show almost identical scavenging reactivity towards reactive carbonyl species, only d-carnosine is poorly adsorbed at the gastrointestinal level and is stable in human plasma. Direct methods for the enantioselective analysis of carnosine are still missing even though they could find more effective applications in the analysis of complex matrices...
December 12, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29230678/fractal-based-radiomic-approach-to-predict-complete-pathological-response-after-chemo-radiotherapy-in-rectal-cancer
#9
Davide Cusumano, Nicola Dinapoli, Luca Boldrini, Giuditta Chiloiro, Roberto Gatta, Carlotta Masciocchi, Jacopo Lenkowicz, Calogero Casà, Andrea Damiani, Luigi Azario, Johan Van Soest, Andre Dekker, Philippe Lambin, Marco De Spirito, Vincenzo Valentini
The aim of this study was to propose a methodology to investigate the tumour heterogeneity and evaluate its ability to predict pathologically complete response (pCR) after chemo-radiotherapy (CRT) in locally advanced rectal cancer (LARC). This approach consisted in normalising the pixel intensities of the tumour and identifying the different sub-regions using an intensity-based thresholding. The spatial organisation of these subpopulations was quantified using the fractal dimension (FD). This approach was implemented in a radiomic workflow and applied to 198 T2-weighted pre-treatment magnetic resonance (MR) images of LARC patients...
December 11, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/29230359/genetic-differentiation-and-phylogeography-of-mediterranean-north-eastern-atlantic-blue-shark-prionace-glauca-l-1758-using-mitochondrial-dna-panmixia-or-complex-stock-structure
#10
Agostino Leone, Ilenia Urso, Dimitrios Damalas, Jann Martinsohn, Antonella Zanzi, Stefano Mariani, Emilio Sperone, Primo Micarelli, Fulvio Garibaldi, Persefoni Megalofonou, Luca Bargelloni, Rafaella Franch, David Macias, Paulo Prodöhl, Séan Fitzpatrick, Marco Stagioni, Fausto Tinti, Alessia Cariani
Background: The blue shark (Prionace glauca, Linnaeus 1758) is one of the most abundant epipelagic shark inhabiting all the oceans except the poles, including the Mediterranean Sea, but its genetic structure has not been confirmed at basin and interoceanic distances. Past tagging programs in the Atlantic Ocean failed to find evidence of migration of blue sharks between the Mediterranean and the adjacent Atlantic, despite the extreme vagility of the species. Although the high rate of by-catch in the Mediterranean basin, to date no genetic study on Mediterranean blue shark was carried out, which constitutes a significant knowledge gap, considering that this population is classified as "Critically Endangered", unlike its open-ocean counterpart...
2017: PeerJ
https://www.readbyqxmd.com/read/29230087/nest-design-in-a-changing-world-great-tit-parus-major-nests-from-a-mediterranean-city-environment-as-a-case-study
#11
Marcel M Lambrechts, Anne Charmantier, Virginie Demeyrier, Annick Lucas, Samuel Perret, Matthieu Abouladzé, Michel Bonnet, Coline Canonne, Virginie Faucon, Stéphanie Grosset, Gaëlle le Prado, Frédéric Lidon, Thierry Noell, Pascal Pagano, Vincent Perret, Stéphane Pouplard, Rémy Spitaliéry, Cyril Bernard, Philippe Perret, Jacques Blondel, Arnaud Grégoire
Investigations of urbanization effects on birds have focused mainly on breeding traits expressed after the nest-building stage (e.g. first-egg date, clutch size, breeding success, and offspring characteristics). Urban studies largely ignored how and why the aspects of nest building might be associated with the degree of urbanization. As urban environments are expected to present novel environmental changes relative to rural environments, it is important to evaluate how nest-building behavior is impacted by vegetation modifications associated with urbanization...
December 2017: Urban Ecosystems
https://www.readbyqxmd.com/read/29230054/single-cell-analysis-of-experience-dependent-transcriptomic-states-in-the-mouse-visual-cortex
#12
Sinisa Hrvatin, Daniel R Hochbaum, M Aurel Nagy, Marcelo Cicconet, Keiramarie Robertson, Lucas Cheadle, Rapolas Zilionis, Alex Ratner, Rebeca Borges-Monroy, Allon M Klein, Bernardo L Sabatini, Michael E Greenberg
Activity-dependent transcriptional responses shape cortical function. However, a comprehensive understanding of the diversity of these responses across the full range of cortical cell types, and how these changes contribute to neuronal plasticity and disease, is lacking. To investigate the breadth of transcriptional changes that occur across cell types in the mouse visual cortex after exposure to light, we applied high-throughput single-cell RNA sequencing. We identified significant and divergent transcriptional responses to stimulation in each of the 30 cell types characterized, thus revealing 611 stimulus-responsive genes...
December 11, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/29229999/heme-accumulation-in-endothelial-cells-impairs-angiogenesis-by-triggering-paraptosis
#13
Sara Petrillo, Deborah Chiabrando, Tullio Genova, Veronica Fiorito, Giada Ingoglia, Francesca Vinchi, Federico Mussano, Stefano Carossa, Lorenzo Silengo, Fiorella Altruda, Giorgio Roberto Merlo, Luca Munaron, Emanuela Tolosano
Heme is required for cell respiration and survival. Nevertheless, its intracellular levels need to be finely regulated to avoid heme excess, which may catalyze the production of reactive oxygen species (ROS) and promote cell death. Here, we show that alteration of heme homeostasis in endothelial cells due to the loss of the heme exporter FLVCR1a, results in impaired angiogenesis. In vitro, FLVCR1a silencing in endothelial cells causes defective tubulogenesis and poor viability due to intracellular heme accumulation...
December 11, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29229997/splics-a-split-green-fluorescent-protein-based-contact-site-sensor-for-narrow-and-wide-heterotypic-organelle-juxtaposition
#14
Domenico Cieri, Mattia Vicario, Marta Giacomello, Francesca Vallese, Riccardo Filadi, Tina Wagner, Tullio Pozzan, Paola Pizzo, Luca Scorrano, Marisa Brini, Tito Calì
Contact sites are discrete areas of organelle proximity that coordinate essential physiological processes across membranes, including Ca2+ signaling, lipid biosynthesis, apoptosis, and autophagy. However, tools to easily image inter-organelle proximity over a range of distances in living cells and in vivo are lacking. Here we report a split-GFP-based contact site sensor (SPLICS) engineered to fluoresce when organelles are in proximity. Two SPLICS versions efficiently measured narrow (8-10 nm) and wide (40-50 nm) juxtapositions between endoplasmic reticulum and mitochondria, documenting the existence of at least two types of contact sites in human cells...
December 11, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29229919/migratory-dendritic-cells-acquire-and-present-lymphatic-endothelial-cell-archived-antigens-during-lymph-node-contraction
#15
Ross M Kedl, Robin S Lindsay, Jeffrey M Finlon, Erin D Lucas, Rachel S Friedman, Beth A Jirón Tamburini
Antigens derived from viral infection or vaccination can persist within a host for many weeks after resolution of the infection or vaccine responses. We previously identified lymphatic endothelial cells (LEC) as the repository for this antigen archival, yet LECs are unable to present their archived antigens to CD8+ T cells, and instead transfer their antigens to CD11c+ antigen-presenting cells (APC). Here we show that the exchange of archived antigens between LECs and APCs is mediated by migratory dendritic cells (DC)...
December 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29229824/molecular-mechanism-for-the-subversion-of-the-retromer-coat-by-the-legionella-effector-ridl
#16
Miguel Romano-Moreno, Adriana L Rojas, Chad D Williamson, David C Gershlick, María Lucas, Michail N Isupov, Juan S Bonifacino, Matthias P Machner, Aitor Hierro
Microbial pathogens employ sophisticated virulence strategies to cause infections in humans. The intracellular pathogen Legionella pneumophila encodes RidL to hijack the host scaffold protein VPS29, a component of retromer and retriever complexes critical for endosomal cargo recycling. Here, we determined the crystal structure of L. pneumophila RidL in complex with the human VPS29-VPS35 retromer subcomplex. A hairpin loop protruding from RidL inserts into a conserved pocket on VPS29 that is also used by cellular ligands, such as Tre-2/Bub2/Cdc16 domain family member 5 (TBC1D5) and VPS9-ankyrin repeat protein for VPS29 binding...
December 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29229744/three-reportedly-unrelated-families-with-liddle-syndrome-inherited-from-a-common-ancestor
#17
Luca Pagani, Yoan Diekmann, Marco Sazzini, Sara De Fanti, Maurizio Rondinelli, Enrico Farnetti, Bruno Casali, Amelia Caretto, Francesca Novara, Orsetta Zuffardi, Paolo Garagnani, Franco Mantero, Mark G Thomas, Donata Luiselli, Ermanno Rossi
Liddle syndrome is considered a rare Mendelian hypertension. We have previously described 3 reportedly unrelated families, native of an Italian area around the Strait of Messina, carrying the same mutation (βP617L) of the epithelial sodium channel. The aims of our study were (1) to evaluate whether a close genomic relationship exists between the 3 families through the analysis of mitochondrial DNA and Y chromosome; and (2) to quantify the genomic relatedness between the patients with Liddle syndrome belonging to the 3 families and assess the hypothesis of a mutation shared through identity by descent...
December 11, 2017: Hypertension
https://www.readbyqxmd.com/read/29229599/downregulating-neuropilin-2-triggers-a-novel-mechanism-enabling-egfr-dependent-resistance-to-oncogene-targeted-therapies
#18
Sabrina Rizzolio, Chiara Battistini, Gabriella Cagnoni, Maria Apicella, Viviana Vella, Silvia Giordano, Luca Tamagnone
Neuropilins are a class of cell surface proteins implicated in cell migration and angiogenesis, with aberrant expression in human tumors. Here we show that the expression of Neuropilin-2 (NRP2) controls EGFR protein levels, thereby impinging on intracellular signaling, viability and response to targeted therapies of oncogene-addicted cells. Notably, increased NRP2 expression in EGFR-addicted tumor cells led to downregulation of EGFR protein and tumor cell growth inhibition. Nrp2 also blunted upregulation of an EGFR "rescue" pathway induced by targeted therapy in Met-addicted carcinoma cells...
December 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/29229582/survival-after-cytoreductive-nephrectomy-in-metastatic-non-clear-cell-renal-cell-carcinoma-patients-a-population-based-study
#19
Michele Marchioni, Marco Bandini, Felix Preisser, Zhe Tian, Anil Kapoor, Luca Cindolo, Giulia Primiceri, Francesco Berardinelli, Alberto Briganti, Shahrokh F Shariat, Luigi Schips, Pierre I Karakiewicz
BACKGROUND: The benefit of cytoreductive nephrectomy (CNT) for cancer-specific mortality (CSM)-free survival is unclear in contemporary metastatic non-clear cell renal cell carcinoma (non-ccmRCC) patients. OBJECTIVE: To assess the role of CNT in non-ccmRCC patients. DESIGN, SETTING, AND PARTICIPANTS: Within Surveillance, Epidemiology, and End Results registry (2001-2014), we identified patients with non-ccmRCC. INTERVENTION: CNT versus no CNT in non-ccmRCC patients...
December 8, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29229491/could-cannabis-liberalisation-lead-to-wider-changes-in-drug-policies-and-outcomes
#20
Brendan Hughes, Lucas Wiessing, Don Des Jarlais, Paul Griffiths
Cannabis policies are changing in some countries. This may have consequences that extend beyond cannabis-specific outcomes, such as an impact on the consumption patterns of other substances. Changes in cannabis policies may also influence policy responses to other drugs, as countries re-assess the balance between law enforcement and public health objectives. If this happens, it could have important health and social consequences, especially in those countries where a 'war on drugs' policy perspective has inhibited investment in evidence based responses in areas such as treatment and harm reduction...
December 8, 2017: International Journal on Drug Policy
keyword
keyword
63759
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"