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JOURNAL ARTICLE
Alexandre Mendes de Almeida Junior, André Satoshi Ferreira, Sabrina Aléssio Camacho, Lucas Gontijo Moreira, Karina Alves de Toledo, Osvaldo N Oliveira, Pedro Henrique Benites Aoki
Phototherapies are promising for noninvasive treatment of aggressive tumors, especially when combining heat induction and oxidative processes. Herein, we show enhanced phototoxicity of gold shell-isolated nanorods conjugated with toluidine blue-O (AuSHINRs@TBO) against human colorectal tumor cells (Caco-2) with synergic effects of photothermal (PTT) and photodynamic therapies (PDT). Mitochondrial metabolic activity tests (MTT) performed on Caco-2 cell cultures indicated a photothermal effect from AuSHINRs owing to enhanced light absorption from the localized surface plasmon resonance (LSPR)...
April 23, 2024: ACS Applied Materials & Interfaces
#2
JOURNAL ARTICLE
Peilong Wang, Jun Gao, Boqi Xiao, Gongbo Long, Qian Zheng, Dahua Shou
Capillary flow has garnered significant attention due to its unique dynamic characteristics that require no external force. Creating a quantitative analytical model to evaluate capillary flow behaviors in root-like networks is essential for enhancing fluid control properties in functional textiles. In this study, we explore the capillary dynamics within root-like networks under the influence of gravity and derive the most rapid capillary flow via structural optimization. The flow time in a capillary is dominated by the capillary pressure, viscous pressure loss, and gravity, each of which exhibits diverse sensitivities to the structures of root-like networks...
April 23, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
#3
JOURNAL ARTICLE
Kevin Pacheco-Barrios, Paulo E P Teixeira, Daniela Martinez-Magallanes, Moacir Silva Neto, Elly Angelica Pichardo, Lucas Camargo, Daniel Lima, Alejandra Cardenas-Rojas, Felipe Fregni
BACKGROUND: The different clinical presentations of fibromyalgia (FMS) may play independent roles in the unclear etiology of cognitive impairments and depressive symptoms seen in this population. Understanding how these clinical presentations are associated with FMS's clinical and neurophysiological aspects is important when developing effective treatments. AIM: To explore the relationship between memory complaints and depressive symptoms, and the different clinical and neurophysiological characteristics of FMS...
April 23, 2024: Pain Medicine
#4
JOURNAL ARTICLE
Giovanni Corso, Elena Marino, Cristina Zanzottera, Carla Oliveira, Loris Bernard, Debora Macis, Joana Figueiredo, Joana Pereira, Patrícia Carneiro, Giulia Massari, Massimo Barberis, Alessandra Margherita De Scalzi, Sergio Vincenzo Taormina, Elham Sajjadi, Claudia Sangalli, Sara Gandini, Oriana D'Ecclesiis, Cristina Maria Trovato, Anna Rotili, Filippo Pesapane, Luca Nicosia, Carlo La Vecchia, Viviana Galimberti, Elena Guerini-Rocco, Bernardo Bonanni, Paolo Veronesi
IMPORTANCE: Pathogenic or likely pathogenic (P/LP) germline CDH1 variants are associated with risk for diffuse gastric cancer and lobular breast cancer (LBC) in the so-called hereditary diffuse gastric cancer (HDGC) syndrome. However, in some circumstances, LBC can be the first manifestation of this syndrome in the absence of diffuse gastric cancer manifestation. OBJECTIVES: To evaluate the frequency of germline CDH1 variants in women with the hereditary LBC (HLBC) phenotype, somatic CDH1 gene inactivation in germline CDH1 variant carriers' tumor samples, and the association of genetic profiles with clinical-pathological data and survival...
April 1, 2024: JAMA Network Open
#5
JOURNAL ARTICLE
Gabrielle Damasceno Costa Dos Santos, Carlos Drielson da Silva Pereira, Camila Caetano da Silva, Marcos Andrade Silva, Lucas Dos Santos Silva, Brenda da Silva Cutrim, Simeone Júlio Dos Santos Castelo Branco, Patrícia Maria Guedes Paiva, Maria Tereza Dos Santos Correia, Rita de Cássia Mendonça de Miranda, Adrielle Zagmignan, Luís Cláudio Nascimento da Silva
Probiotic-containing foods are among the most appreciated functional foods; however, probiotic-based dairy products cannot be consumed by people who are lactose intolerant, allergic to milk, or vegetarian or vegan individuals. Thus, new non-dairy matrices have been tested for probiotics delivery. This study evaluated the growth and viability of Limosilactobacillus fermentum ATCC 23271 and Lacticaseibacillus rhamnosus ATCC 9595 in Pitanga juice (Eugenia uniflora L.). The effects of the fermentation on the antioxidant and anti-infective properties of the juice were also analyzed...
April 23, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
#6
JOURNAL ARTICLE
Luca Kiss, Bence Szikora, Karina J Linnell
Although background music listening during attention-demanding tasks is common, there is little research on how it affects fluctuations in attentional state and how these fluctuations are linked to physiological arousal. The present study built on Kiss and Linnell (2021) - showing a decrease in mind-wandering and increase in task-focus states with background music - to explore the link between attentional state and arousal with and without background music. 39 students between the ages of 19-32 completed a variation of the Psychomotor Vigilance Task in silence and with their self-selected background music (music they would normally listen to during attention-demanding tasks)...
April 23, 2024: Psychological Research
#7
REVIEW
Kelsey Caetano-Anollés, M Fayez Aziz, Fizza Mughal, Gustavo Caetano-Anollés
The principle of continuity demands the existence of prior molecular states and common ancestors responsible for extant macromolecular structure. Here, we focus on the emergence and evolution of loop prototypes - the elemental architects of protein domain structure. Phylogenomic reconstruction spanning superkingdoms and viruses generated an evolutionary chronology of prototypes with six distinct evolutionary phases defining a most parsimonious evolutionary progression of cellular life. Each phase was marked by strategic prototype accumulation shaping the structures and functions of common ancestors...
April 23, 2024: Journal of Molecular Evolution
#8
JOURNAL ARTICLE
Aniket Bhattacharya, Paola Parlanti, Luca Cavallo, Edward Farrow, Tyler Spivey, Alessandra Renieri, Francesca Mari, M Chiara Manzini
Intellectual disability (ID) and autism spectrum disorder (ASD) are genetically heterogeneous with hundreds of identified risk genes, most affecting only a few patients. Novel missense variants in these genes are being discovered as clinical exome sequencing is now routinely integrated into diagnosis, yet most of them are annotated as variants of uncertain significance (VUS). VUSs are a major roadblock in using patient genetics to inform clinical action. We developed a framework to characterize VUSs in Coiled-coil and C2 domain containing 1A (CC2D1A), a gene causing autosomal recessive ID with comorbid ASD in 40% of cases...
April 23, 2024: Human Molecular Genetics
#9
JOURNAL ARTICLE
Marco Zuin, Roberto Ferrari, Gabriele Guardigli, Michele Malagù, Francesco Vitali, Ottavio Zucchetti, Emanuele D'Aniello, Luca Di Ienno, Federico Gibiino, Paolo Cimaglia, Daniele Grosseto, Alessandro Corzani, Marcello Galvani, Paolo Ortolani, Andrea Rubboli, Gianfranco Tortorici, Gianni Casella, Biagio Sassone, Alessandro Navazio, Luca Rossi, Daniela Aschieri, Roberto Mezzanotte, Marco Manfrini, Matteo Bertini
We aimed to develop and validate a COVID-19 specific scoring system, also including some ECG features, to predict all-cause in-hospital mortality at admission. Patients were retrieved from the ELCOVID study (ClinicalTrials.gov identifier: NCT04367129), a prospective, multicenter Italian study enrolling COVID-19 patients between May to September 2020. For the model validation, we randomly selected two-thirds of participants to create a derivation dataset and we used the remaining one-third of participants as the validation set...
April 23, 2024: Internal and Emergency Medicine
#10
JOURNAL ARTICLE
Giuseppe Lapadula, Luca Mezzadri, Giustina Lo Cascio, Laura Antolini, Sergio Malandrin, Alice Ranzani, Silvia Limonta, Annalisa Cavallero, Paolo Bonfanti
PURPOSE: Antibodies against SARS-CoV-2 spike (anti-S) may confer protection against symptomatic COVID-19. Whether their level predicts progression among those with COVID-19 pneumonia remains unclear. METHODS: We conducted a retrospective cohort study to assess predictors of anti-S levels and whether anti-S titer is associated with death or mechanical ventilation (MV). Adults hospitalized for COVID-19 pneumonia between July 2021 and July 2022 were enrolled if anti-S had been measured within 72 h of admission...
April 23, 2024: Infection
#11
JOURNAL ARTICLE
Yongrong Liao, Leonid Andronov, Xiaotian Liu, Junyan Lin, Lucile Guerber, Linjie Lu, Arantxa Agote-Arán, Evanthia Pangou, Li Ran, Charlotte Kleiss, Mengdi Qu, Stephane Schmucker, Luca Cirillo, Zhirong Zhang, Daniel Riveline, Monica Gotta, Bruno P Klaholz, Izabela Sumara
Assembly of macromolecular complexes at correct cellular sites is crucial for cell function. Nuclear pore complexes (NPCs) are large cylindrical assemblies with eightfold rotational symmetry, built through hierarchical binding of nucleoporins (Nups) forming distinct subcomplexes. Here, we uncover a role of ubiquitin-associated protein 2-like (UBAP2L) in the assembly and stability of properly organized and functional NPCs at the intact nuclear envelope (NE) in human cells. UBAP2L localizes to the nuclear pores and facilitates the formation of the Y-complex, an essential scaffold component of the NPC, and its localization to the NE...
July 1, 2024: Journal of Cell Biology
#12
JOURNAL ARTICLE
Katerina Deike, Andreas Decker, Paul Scheyhing, Julia Harten, Nadine Zimmermann, Daniel Paech, Oliver Peters, Silka D Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Okka Kimmich, Jens Wiltfang, Claudia Bartels, Niels Hansen, Frank Jessen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H Munk, Annika Spottke, Nina Roy, Michael Wagner, Sandra Roeske, Michael T Heneka, Frederic Brosseron, Alfredo Ramirez, Laura Dobisch, Steffen Wolfsgruber, Luca Kleineidam, Renat Yakupov, Melina Stark, Matthias C Schmid, Moritz Berger, Stefan Hetzer, Peter Dechent, Klaus Scheffler, Gabor C Petzold, Anja Schneider, Alexander Effland, Alexander Radbruch
OBJECTIVES: Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when the anatomy of the perivascular space (PVS) is altered during AD progression. Therefore, this study investigates the association between PVS volume and AD progression in cognitively unimpaired (CU) individuals, both with and without subjective cognitive decline (SCD), and in those clinically diagnosed with mild cognitive impairment (MCI) or mild AD...
April 23, 2024: Investigative Radiology
#13
JOURNAL ARTICLE
Olujolagbe Layinka, Luca D Hargitai, Punit Shah, Lucy H Waldren, Florence Y N Leung
Improving our understanding of autism, ADHD, dyslexia and other neurodevelopmental conditions requires collaborations between genetics, psychiatry, the social sciences and other fields of research.
April 23, 2024: ELife
#14
JOURNAL ARTICLE
Matthew A Greenwald, Suzanne L Meinig, Lucas M Plott, Cristian Roca, Matthew G Higgs, Nicholas P Vitko, Matthew R Markovetz, Kaitlyn R Rouillard, Jerome Carpenter, Mehmet Kesimer, David B Hill, Jonathan C Schisler, Matthew C Wolfgang
UNLABELLED: The airway milieu of individuals with muco-obstructive airway diseases (MADs) is defined by the accumulation of dehydrated mucus due to hyperabsorption of airway surface liquid and defective mucociliary clearance. Pathological mucus becomes progressively more viscous with age and disease severity due to the concentration and overproduction of mucin and accumulation of host-derived extracellular DNA (eDNA). Respiratory mucus of MADs provides a niche for recurrent and persistent colonization by respiratory pathogens, including Pseudomonas aeruginosa , which is responsible for the majority of morbidity and mortality in MADs...
April 23, 2024: MBio
#15
JOURNAL ARTICLE
Mehdi Khaleghi, Lucas P Carlstrom, Claudio Andres Callejas, Peter Kobalka, Ricardo Carrau, Daniel M Prevedello
BACKGROUND AND IMPORTANCE: Various invasive oculoplastic procedures are commonly utilized to control the rectus muscles and widen the surgical corridor through the endoscopic endonasal removal of large orbital apex cavernous hemangiomas (OACHs). They require additional transconjunctival incision, rectus muscle insertional retraction, or muscle deinsertion at the globe that might not be safe and lead to prolonged postoperative extraocular muscle dysfunction. In this article, the authors described a modified 3-handed extracapsular technique for the resection of a large OACH without an additional procedure for rectus muscle control...
April 23, 2024: Operative Neurosurgery (Hagerstown, Md.)
#16
JOURNAL ARTICLE
Marek Niedoszytko, Aleksandra Gorska, Knut Brockow, Patrizia Bonadonna, Magdalena Lange, Hanneke Kluin-Nelemans, Hanneke Oude-Elberink, Vito Sabato, Khalid Shoumariyeh, Dagmar von Bubnoff, Sabine Müller, Anja Illerhaus, Michael Doubek, Irena Angelova-Fischer, Olivier Hermine, Michel Arock, Chiara Elena, Luca Malcovati, Akif Selim Yavuz, Tanja Daniela Schug, Anna Belloni Fortina, Várkonyi Judit, Jason Gotlib, Jens Panse, Vladan Vucinic, Andreas Reiter, Juliana Schwaab, Massimo Triggiani, Mattias Mattsson, Christine Breynaert, Jan Romantowski, Roberta Zanotti, Elisa Olivieri, Alexander Zink, Annick van de Ven, Alex Stefan, Stephane Barete, Francesca Caroppo, Cecelia Perkins, Vanessa Kennedy, Deborah Christen, Mohamad Jawhar, Johannes Luebke, Roberta Parente, Kerstin Levedahl, Emir Hadzijusufovic, Karin Hartmann, Boguslaw Nedoszytko, Wolfgang R Sperr, Peter Valent
BACKGROUND: Hypersensitivity reactions (HR) are common in mastocytosis. However, little is known about triggers and risk factors. The registry of the European Competence Network on Mastocytosis (ECNM) enables reliable studies in a larger cohort of mastocytosis patients. We assessed prevalence, triggers and risk factors of HR in adults with mastocytosis in the ECNM registry. METHODS: Data were collected in 27 ECNM centers. We analyzed potential triggers (Hymenoptera venoms, food, drug, inhalant and others) and risk factors at diagnosis and during follow-up...
April 23, 2024: Allergy
#17
JOURNAL ARTICLE
Luca Andriolo, Theodorakys Marín Fermín, Giulia Marcella Maryse Chiari Gaggia, Andreas Serner, Elizaveta Kon, Emmanuel Papakostas, Andrew Massey, Peter Verdonk, Giuseppe Filardo
OBJECTIVE: To systematically review the literature and analyze clinical outcomes and return-to-sport after surgical management of cartilage injuries in football players. DESIGN: A systematic literature review was performed in August 2023 on PubMed, WebOfScience, and Cochrane Library to collect studies on surgical strategies for cartilage lesions in football players. Methodological quality and risk of bias were assessed with the modified Coleman Methodology score and RoB2 and RoBANS2 tools...
April 23, 2024: Cartilage
#18
JOURNAL ARTICLE
João Pedro Rueda Furlan, Rafael da Silva Rosa, Micaela Santana Ramos, Lucas David Rodrigues Dos Santos, Eduardo Angelino Savazzi, Eliana Guedes Stehling
BACKGROUND: Klebsiella pneumoniae species complex (KpSC) is an important disseminator of carbapenemase-encoding genes, mainly blaKPC-2 and blaNDM-1 , from hospitals to the environment. Consequently, carbapenem-resistant strains can be spread through the agrifood system, raising concerns about food safety. Therefore, this study aimed to isolate carbapenem-resistant KpSC strains from agricultural and environmental sectors and characterize them by phenotypic, molecular, and genomic analyses...
April 23, 2024: Journal of the Science of Food and Agriculture
#19
JOURNAL ARTICLE
David Shaholli, Chiara Bellenzier, Corrado Colaprico, Francesca Vezza, Giovanna Carluccio, Luca Moretti, Maria Vittoria Manai, Vanessa India Barletta, Alice Mannocci, Giuseppe La Torre
BACKGROUND: The Mini-Z is a questionnaire created to evaluate the levels of burnout in healthcare workers. It consists of 10 items rated using a 5-point Likert scale and one open question. It explores three outcomes (burnout, stress and satisfaction) and seven drivers of burnout (work control, work chaos, teamwork, values alignment with leadership, documentation time pressure, EMR use at home, and EMR proficiency). The aim of this study is to validate the Italian version of the Mini-Z, comparing it with the other most used scales...
2024: Rivista di Psichiatria
#20
Delcroix Luca, Tamburello Sara, Innocenti Marco, Campanacci Domenico Andrea
BACKGROUND: Post-oncologic surgical reconstruction of lower limbs in pediatrics remains a challenging topic. Microsurgical techniques allow reconstructions of large bony defects. The use of vascularized fibular flap with allograft has proven to be an ideal biologic construct. We aim to assess the success rate of this operation, including flap survival, bony union, weight-bearing ambulation, and complications in a long-term follow-up in our case series compared to the literature. PATIENTS AND METHODS: Our case-series includes 18 femoral resections (9 osteosarcomas, 8 Ewing sarcoma, and 1 desmoid tumor) and 15 tibial resections (10 osteosarcoma, 4 Ewing sarcoma, and 1 Malignant Fibrous Histiocytoma)...
May 2024: Microsurgery
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