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https://www.readbyqxmd.com/read/29774897/development-of-highly-sensitive-fluorescent-probes-for-the-detection-of-%C3%AE-galactosidase-activity-application-to-the-real-time-monitoring-of-senescence-in-live-cells
#1
Mauro Safir Filho, Pascal Dao, Maéva Gesson, Anthony R Martin, Rachid Benhida
We report the development of four novel fluorescent probes to monitor the activity of the β-galactosidase enzyme (β-gal), in vitro and in living cells. The fluorophores are based on a 6-amino-styryl-benzothiazole push-pull core and display a strong ICT emission. The probes encompass the fluorescent motif that is connected to a β-d-galactopyranoside moiety through a self-immolative benzyl carbamate linker (βGal-1-4). The screening of four different fluorophores enabled us to access new light-up and two-band ratiometric reporters...
May 18, 2018: Analyst
https://www.readbyqxmd.com/read/29762055/evaluating-the-effect-of-increased-pitch-iterative-reconstruction-and-dual-source-ct-on-dose-reduction-and-image-quality
#2
Joanna Gariani, Steve P Martin, Diomidis Botsikas, Christoph D Becker, Xavier Montet
OBJECTIVE: to compare radiation dose and image quality of thoraco-abdominal scans obtained with a high-pitch protocol (pitch 3.2) and iterative reconstruction (SAFIRE) in comparison to standard pitch reconstructed with FBP using dual-source CT. METHODS: 114 CT scans (Somatom Definition Flash, Siemens), 39 thoracic scans, 54 thoraco-abdominal scans and 21 abdominal scans were performed. Analysis of three protocols was undertaken; pitch of 1 reconstructed with FBP, pitch of 3...
May 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29728223/effects-of-various-generations-of-iterative-ct-reconstruction-algorithms-on-low-contrast-detectability-as-a-function-of-the-effective-abdominal-diameter-a-quantitative-task-based-phantom-study
#3
Anais Viry, Christoph Aberle, Damien Racine, Jean-François Knebel, Sebastian T Schindera, Sabine Schmidt, Fabio Becce, Francis R Verdun
PURPOSE: To investigate how various generations of iterative reconstruction (IR) algorithms impact low-contrast detectability (LCD) in abdominal computed tomography (CT) for different patient effective diameters, using a quantitative task-based approach. METHODS: Investigations were performed using an anthropomorphic abdominal phantom with two optional additional rings to simulate varying patient effective diameters (25, 30, and 35 cm), and containing multiple spherical targets (5, 6, and 8 mm in diameter) with a 20-HU contrast difference...
April 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29690714/-comparative-study-on-image-quality-of-third-generation-dual-source-ct-pulmonary-angiography-combined-with-advanced-modeled-iterative-reconstruction
#4
X X Liang, L D Liang, Y Y Zhang, J B Gao, Y G Zhang, X Liu, Q Chi
Objective: To quantitatively evaluate the quality of advanced modeled iterative reconstruction (ADMIRE) combined with 70 kVp and linear blending images in low dose dual energy (70 kVp/sn150 kVp) pulmonary angiography. Methods: A total of 74 cases with normal BMI underwent dual-source CT dual-energy pulmonary angiography with small amount of contrast medium (30 ml) from 2015 to 2017 from the First Affiliated Hospital of Zhengzhou University were randomly assigned to protocol Ⅰ(100 kVp/sn140 kVp) or protocol Ⅱ(70 kVp/sn150 kVp)...
April 3, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29657441/percutaneous-upper-extremity-fracture-fixation-using-a-novel-glass-based-adhesive
#5
Paul Zalzal, Oleg Safir, Adel Alhalawani, Marcello Papini, Mark Towler
Objective: To develop a surgical technique for percutaneous upper extremity fracture fixation using a novel glass-based adhesive. Methods: Three intact upper extremity cadaveric specimens with undisturbed soft tissues were obtained. Two were used to model a wrist fracture, and the third to model a proximal humerus fracture. Fractures were produced using a small osteotome in a percutaneous fashion. Banna Bone Adhesive (BBA) was delivered to the fracture site percutaneously using a 16 gauge needle under bi-planar fluoroscopic guidance...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29573913/fresh-osteochondral-allograft-transplantation-for-treatment-of-large-cartilage-defects-of-the-femoral-head-a-minimum-two-year-follow-up-study-of-twenty-two-patients
#6
Xin Y Mei, Ibrahim S Alshaygy, Oleg A Safir, Allan E Gross, Paul R Kuzyk
BACKGROUND: Controversy remains over the surgical management of large osteochondral lesions of the femoral head in young, active patients. The purpose of this study is to assess midterm clinical and radiographic outcomes after fresh osteochondral allograft transplantation (OAT) for large femoral head lesions at minimum 2-year follow-up. METHODS: A retrospective review of prospectively collected data was performed for 22 patients under the age of 50 years with defined femoral head osteochondral lesions who underwent fresh OAT between 2008 and 2015...
February 9, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29549075/medication-adherence-apps-review-and-content-analysis
#7
REVIEW
Imran Ahmed, Niall Safir Ahmad, Shahnaz Ali, Shair Ali, Anju George, Hiba Saleem Danish, Encarl Uppal, James Soo, Mohammad H Mobasheri, Dominic King, Benita Cox, Ara Darzi
BACKGROUND: Medication adherence is an expensive and damaging problem for patients and health care providers. Patients adhere to only 50% of drugs prescribed for chronic diseases in developed nations. Digital health has paved the way for innovative smartphone solutions to tackle this challenge. However, despite numerous apps available claiming to improve adherence, a thorough review of adherence apps has not been carried out to date. OBJECTIVE: The aims of this study were to (1) review medication adherence apps available in app repositories in terms of their evidence base, medical professional involvement in development, and strategies used to facilitate behavior change and improve adherence and (2) provide a system of classification for these apps...
March 16, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29475151/ct-angiography-of-the-aorta-in-patients-with-marfan-disease-high-pitch-mdct-at-different-levels-of-tube-voltage-combined-with-sinogram-affirmed-iterative-reconstruction
#8
P Freyhardt, N Solowjowa, G Böning, J Kahn, B Aufmesser, P Haage, F Streitparth
OBJECTIVES: Aim of the study was the comparison of high-pitch dual-source CTA of the aorta acquired with different tube currents and methods of image reconstruction in patients with Marfan Disease (MFS). BACKGROUND: Patients with MFS receive repeatedly CT examinations of the entire aorta what leads to high cumulative lifetime radiation doses. Routine clinical use of low-kV-protocols in combination with iterative reconstruction for imaging of the aorta is still limited although this approach may be of great benefit for patients in need of serial follow-up scans...
February 15, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29470108/application-of-80-kvp-scan-and-raw-data-based-iterative-reconstruction-for-reduced-iodine-load-abdominal-pelvic-ct-in-patients-at-risk-of-contrast-induced-nephropathy-referred-for-oncological-assessment-effects-on-radiation-dose-image-quality-and-renal-function
#9
Yasunori Nagayama, Shota Tanoue, Akinori Tsuji, Joji Urata, Mitsuhiro Furusawa, Seitaro Oda, Takeshi Nakaura, Daisuke Utsunomiya, Eri Yoshida, Morikatsu Yoshida, Masafumi Kidoh, Machiko Tateishi, Yasuyuki Yamashita
OBJECTIVE: To evaluate the image quality, radiation dose, and renal safety of contrast medium (CM)-reduced abdominal-pelvic CT combining 80-kVp and sinogram-affirmed iterative reconstruction (SAFIRE) in patients with renal dysfunction for oncological assessment. METHODS: We included 45 patients with renal dysfunction (estimated glomerular filtration rate  <45 ml per min per 1.73 m2 ) who underwent reduced-CM abdominal-pelvic CT (360 mgI kg-1 , 80-kVp, SAFIRE) for oncological assessment...
May 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29306386/optimal-abdominal-ct-protocol-for-obese-patients
#10
A Qurashi, L Rainford, A Ajlan, K Khashoggi, L Ashkar, M Al-Raddadi, M Al-Ghamdi, M Al-Thobaiti, S Foley
INTRODUCTION: This study investigated the impact of different protocols on radiation dose and image quality for obese patients undergoing abdominal CT examinations. METHODS: Five abdominal/pelvis CT protocols employed across three scanners from a single manufacturer in a single centre used a variety of parameters (kV: 100/120, reference mAs: 150/190/218/250/300, image reconstruction: filtered back projection (FBP)/iterative (IR)). The routine protocol employed 300 reference mAs and 120 kV...
February 2018: Radiography
https://www.readbyqxmd.com/read/29178957/triple-combination-antibiotic-therapy-for-carbapenemase-producing-klebsiella-pneumoniae-a-systematic-review
#11
REVIEW
David M Jacobs, M Courtney Safir, Dennis Huang, Faisal Minhaj, Adam Parker, Gauri G Rao
BACKGROUND: The spread of carbapenemase-producing K. pneumoniae (CPKP) has become a significant problem worldwide. Combination therapy for CPKP is encouraging, but polymyxin resistance to many antibiotics is hampering effective treatment. Combination therapy with three or more antibiotics is being increasingly reported, therefore we performed a systematic review of triple combination cases in an effort to evaluate their clinical effectiveness for CPKP infections. METHODS: The PubMed database was searched to identify all published clinical outcomes of CPKP infections treated with triple combination therapy...
November 25, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/29135034/implementation-and-performance-of-the-artificial-force-induced-reaction-method-in-the-grrm17-program
#12
Satoshi Maeda, Yu Harabuchi, Makito Takagi, Kenichiro Saita, Kimichi Suzuki, Tomoya Ichino, Yosuke Sumiya, Kanami Sugiyama, Yuriko Ono
This article reports implementation and performance of the artificial force induced reaction (AFIR) method in the upcoming 2017 version of GRRM program (GRRM17). The AFIR method, which is one of automated reaction path search methods, induces geometrical deformations in a system by pushing or pulling fragments defined in the system by an artificial force. In GRRM17, three different algorithms, that is, multicomponent algorithm (MC-AFIR), single-component algorithm (SC-AFIR), and double-sphere algorithm (DS-AFIR), are available, where the MC-AFIR was the only algorithm which has been available in the previous 2014 version...
November 14, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29114620/reducing-radiation-dose-and-enhancing-imaging-quality-of-4dct-for-radiation-therapy-using-iterative-reconstruction-algorithms
#13
George Noid, An Tai, Guang-Pei Chen, Jared Robbins, X Allen Li
Purpose: Four-dimensional computed tomography (CT) images are typically used to quantify the necessary internal target volumes for thoracic and abdominal tumors. However, 4-dimensional CT is typically associated with excessive imaging dose to patients and the situation is exacerbated when using repeat 4-dimensional CT imaging on a weekly or daily basis throughout fractionated therapy. The aim of this work is to evaluate an iterative reconstruction (IR) algorithm that helps reduce the imaging dose to the patient while maintaining imaging quality as quantified by point spread function and contrast-to-noise ratios (CNRs)...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29066126/diagnostic-performance-of-a-low-dose-triple-rule-out-ct-angiography-using-safire-in-emergency-department
#14
S Si-Mohamed, J Greffier, X Bobbia, A Larbi, J Delicque, E Khasanova, J-P Beregi, F Macri
OBJECTIVES: To compare the diagnostic performance of "triple rule out" CT angiography (TRO-CTA) at 100kVp using sinogram affirmed iterative reconstruction (SAFIRE) with TRO-CTA at 120kVp using filtered back projection (FBP) in patients with acute chest pain. METHODS: Consecutive non-prepared patients from a single radiological emergency department, referred for acute chest pain evaluation with TRO-CTA, were randomly assigned to two different TRO-CTA protocols...
December 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29042698/evaluating-low-kv-dual-source-ct-angiography-by-high-pitch-spiral-acquisition-and-iterative-reconstruction-in-pediatric-congenital-heart-disease-patients
#15
Yohei Marukawa, Shuhei Sato, Takashi Tanaka, Akihiro Tada, Yuichiro Kanie, Susumu Kanazawa
We retrospectively evaluated the qualities of pediatric cardiovascular dual-source computed tomography (DSCT) images reconstructed by sinogram-affirmed iterative reconstruction (SAFIRE) and filtered back projection (FBP). We analyzed the cases of 287 congenital heart disease (CHD) patients < 5 years old, referred to our department in August 2013-March 2015. We divided them into two groups according to tube voltage (70 kVp, n=147; 80 kVp, n=140). All images were acquired by a CARE kV system and reconstructed by FBP and SAFIRE...
October 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29029768/value-of-100-kvp-scan-with-sinogram-affirmed-iterative-reconstruction-algorithm-on-a-single-source-ct-system-during-whole-body-ct-for-radiation-and-contrast-medium-dose-reduction-an-intra-individual-feasibility-study
#16
Y Nagayama, T Nakaura, S Oda, A Tsuji, J Urata, M Furusawa, S Tanoue, D Utsunomiya, Y Yamashita
AIM: To perform an intra-individual investigation of the usefulness of a contrast medium (CM) and radiation dose-reduction protocol using single-source computed tomography (CT) combined with 100 kVp and sinogram-affirmed iterative reconstruction (SAFIRE) for whole-body CT (WBCT; chest-abdomen-pelvis CT) in oncology patients. MATERIALS AND METHODS: Forty-three oncology patients who had undergone WBCT under both 120 and 100 kVp protocols at different time points (mean interscan intervals: 98 days) were included retrospectively...
February 2018: Clinical Radiology
https://www.readbyqxmd.com/read/28842662/low-tube-voltage-liver-mdct-with-sinogram-affirmed-iterative-reconstructions-for-the-detection-of-hepatocellular-carcinoma
#17
B Pregler, L P Beyer, A Teufel, C Niessen, C Stroszczynski, H Brodoefel, P Wiggermann
Aim of this study was to compare low tube voltage computed tomography (80 kV) of the liver using iterative image reconstruction (SAFIRE) with standard computed tomography (120 kV) using filtered back-projection (FBP) for the detection of hepatocellular carcinoma (HCC). 46 patients (43 men) with 93 HCC confirmed by 3 T MRI with Gd-EOB-DPTA, in inconclusive cases combined with contrast-enhanced ultrasound, underwent dual-energy CT. The raw data of the 80 kV tube was reconstructed using the iterative reconstruction algorithm SAFIRE with two strengths (I3 and I5)...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807365/-the-breakthrough-of-personalized-medicine-new-hopes-and-new-challenges
#18
REVIEW
Ronan Flippot, Christophe Massard, Edouard Auclin, David Azria, Héloïse Bourien, Philippe Rochigneux, Antoine Schernberg, Loïc Verlingue, Lara Zafrani, Stéphane Vignot
The development of personalized medicine in oncology is based on biomarkers that help select populations for more efficient and less toxic therapies. The onset of molecular biology led to new paradigms in drug development, with efficacy data reported in early clinical trials and accelerated approvals. Multiple clinical trials, including SHIVA, SAFIR-01 and MOSCATO-01, have been developed to evaluate the interest of treatment decision-making based on tumor molecular profiling, with the ambition to replace historical clinical and pathological classifications...
September 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28780298/comparative-cost-analysis-teleurology-vs-conventional-face-to-face-clinics
#19
Vitaly Zholudev, Ilan J Safir, Mark N Painter, John A Petros, Christopher P Filson, Muta M Issa
OBJECTIVE: To compare costs associated with teleurology vs face-to-face clinic visits for initial outpatient hematuria evaluation. MATERIALS AND METHODS: The analysis included 3 cost domains: transportation, clinic operations, and patient time. Transportation cost was based on standard government travel reimbursement. Clinic staff cost was based on hourly salary plus fringe benefits. For a face-to-face clinic encounter, patient time included time spent for travel, parking, walking to and from clinic, checking in and checking out, nursing evaluation, urologic evaluation, laboratory, and waiting...
March 2018: Urology
https://www.readbyqxmd.com/read/28764856/image-quality-of-ct-angiography-in-young-children-with-congenital-heart-disease-a-comparison-between-the-sinogram-affirmed-iterative-reconstruction-safire-and-advanced-modelled-iterative-reconstruction-admire-algorithms
#20
COMPARATIVE STUDY
S B Nam, D W Jeong, K S Choo, K J Nam, J-Y Hwang, J W Lee, J Y Kim, S J Lim
AIM: To compare the image quality of computed tomography angiography (CTA) reconstructed by sinogram-affirmed iterative reconstruction (SAFIRE) with that of advanced modelled iterative reconstruction (ADMIRE) in children with congenital heart disease (CHD). MATERIAL AND METHODS: Thirty-one children (8.23±13.92 months) with CHD who underwent CTA were enrolled. Images were reconstructed using SAFIRE (strength 5) and ADMIRE (strength 5). Objective image qualities (attenuation, noise) were measured in the great vessels and heart chambers...
December 2017: Clinical Radiology
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