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https://www.readbyqxmd.com/read/28170300/effect-of-radiation-dose-reduction-and-reconstruction-algorithm-on-image-noise-contrast-resolution-and-detectability-of-subtle-hypoattenuating-liver-lesions-at-multidetector-ct-filtered-back-projection-versus-a-commercial-model-based-iterative-reconstruction
#1
Justin Solomon, Daniele Marin, Kingshuk Roy Choudhury, Bhavik Patel, Ehsan Samei
Purpose To determine the effect of radiation dose and iterative reconstruction (IR) on noise, contrast, resolution, and observer-based detectability of subtle hypoattenuating liver lesions and to estimate the dose reduction potential of the IR algorithm in question. Materials and Methods This prospective, single-center, HIPAA-compliant study was approved by the institutional review board. A dual-source computed tomography (CT) system was used to reconstruct CT projection data from 21 patients into six radiation dose levels (12...
February 7, 2017: Radiology
https://www.readbyqxmd.com/read/28125231/improved-fluorescent-protein-contrast-and-discrimination-by-optically-controlling-dark-state-lifetimes
#2
Yen-Cheng Chen, Robert M Dickson
Modulation and optical control of photoswitchable fluorescent protein (PS-FP) dark state lifetimes drastically improves sensitivity and selectivity in fluorescence imaging. The dark state population of PS-FPs generates an out-of-phase fluorescence component relative to the sinusoidally modulated 488 nm laser excitation. Because this apparent phase advanced emission results from slow recovery to the fluorescent manifold, we hasten recovery and, therefore, modulation frequency by varying coillumination intensity at 405 nm...
February 16, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28050639/cerebral-bone-subtraction-ct-angiography-using-80%C3%A2-kvp-and-sinogram-affirmed-iterative-reconstruction-contrast-medium-and-radiation-dose-reduction-with-improvement-of-image-quality
#3
Yasunori Nagayama, Takeshi Nakaura, Akinori Tsuji, Joji Urata, Mitsuhiro Furusawa, Hideaki Yuki, Kenichiro Hirarta, Seitaro Oda, Masafumi Kidoh, Daisuke Utsunomiya, Yasuyuki Yamashita
INTRODUCTION: The purpose of this study was to evaluate the feasibility of a contrast medium (CM), radiation dose reduction protocol for cerebral bone-subtraction CT angiography (BSCTA) using 80-kVp and sinogram-affirmed iterative reconstruction (SAFIRE). METHODS: Seventy-five patients who had undergone BSCTA under the 120- (n = 37) or the 80-kVp protocol (n = 38) were included. CM was 370 mgI/kg for the 120-kVp and 296 mgI/kg for the 80-kVp protocol; the 120- and the 80-kVp images were reconstructed with filtered back-projection (FBP) and SAFIRE, respectively...
January 3, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28048150/th-cd-207b-04-is-ttf-a-true-representation-of-the-sharpness-property-of-a-non-linear-ct-system
#4
M Robins, J Solomon, E Samei
PURPOSE: To investigate if the task-transfer-function (TTF) accurately models the transfer properties of a CT system for lung nodule imaging. METHODS: An anthropomorphic lung phantom was imaged using a standard chest protocol on a clinical CT scanner with and without 24 physically inserted synthetic lesions (nominal diameter: 8 - 10 mm). Images were reconstructed using FBP and iterative algorithm (SAFIRE, Siemens Healthcare). 3D TTF was measured using an established technique...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048039/su-f-i-74-dose-evaluation-based-on-monte-carlo-simulation-of-three-dimensional-rotational-angiography-during-hepatic-transarterial-chemoembolization-procedures
#5
Y Hwang, K Lui, Y Lin, H Tsai
PURPOSE: This study was aimed to investigate the dose with patient performing three-dimensional (3D) angiography imaging during hepatic transarterial chemoembolization (TACE) procedures. METHODS: Organ doses and effective doses calculations were retrospectively performed in 88 patients (61 males and 27 females with averaged age of 65.4±12.6 years old) referred for hepatic TACE on a digital flat-panel angiography system (Bransist safire; Shimadzu) using software (PCXMC; Helsinki, Finland) based on Monte Carlo technique...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047530/su-f-p-45-clinical-experience-with-radiation-dose-reduction-of-ct-examinations-using-iterative-reconstruction-algorithms
#6
V Weir, J Zhang
PURPOSE: Iterative reconstruction (IR) algorithms have been adopted by medical centers in the past several years. IR has a potential to substantially reduce patient dose while maintaining or improving image quality. This study characterizes dose reductions in clinical settings for CT examinations using IR. METHODS: We retrospectively analyzed dose information from patients who underwent abdomen/pelvis CT examinations with and without contrast media in multiple locations of our Healthcare system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27935766/dual-source-single-energy-multidetector-ct-used-to-obtain-multiple-radiation-exposure-levels-within-the-same-patient-phantom-development-and-clinical-validation
#7
Davide Bellini, Juan Carlos Ramirez-Giraldo, Alex Bibbey, Justin Solomon, Lynne M Hurwitz, Alfredo Farjat, Achille Mileto, Ehsan Samei, Daniele Marin
Purpose To develop, in a phantom environment, a method to obtain multidetector computed tomographic (CT) data sets at multiple radiation exposure levels within the same patient and to validate its use for potential dose reduction by using different image reconstruction algorithms for the detection of liver metastases. Materials and Methods The American College of Radiology CT accreditation phantom was scanned by using a dual-source multidetector CT platform. By adjusting the radiation output of each tube, data sets at six radiation exposure levels (100%, 75%, 50%, 37...
December 5, 2016: Radiology
https://www.readbyqxmd.com/read/27924781/development-of-sns2-rgo-nanosheet-composite-for-cost-effective-aqueous-hybrid-supercapacitors
#8
Himani Chauhan, Manoj K Singh, Praveen Kumar, Safir Ahmad Hashmi, Sasanka Deka
The development of low cost supercapacitor cells with unique capacitive properties is essential for many domestic and industrial purposes. Here we report the first ever application of SnS2-reduced graphene oxide (SnS2/RGO) layered nanocomposite as a superior electrode material for symmetric aqueous hybrid supercapacitors. We synthesized SnS2/RGO nanocomposite comprised of nanosheets of SnS2 and graphene oxide via a one-pot hydrothermal approach. in situ as-synthesized SnS2/RGO is devised for the first time to give high specific capacitance 500 Fg(-1), energy density 16...
January 13, 2017: Nanotechnology
https://www.readbyqxmd.com/read/27908164/comparison-of-low-contrast-detectability-between-two-ct-reconstruction-algorithms-using-voxel-based-3d-printed-textured-phantoms
#9
Justin Solomon, Alexandre Ba, François Bochud, Ehsan Samei
PURPOSE: To use novel voxel-based 3D printed textured phantoms in order to compare low-contrast detectability between two reconstruction algorithms, FBP (filtered-backprojection) and SAFIRE (sinogram affirmed iterative reconstruction) and determine what impact background texture (i.e., anatomical noise) has on estimating the dose reduction potential of SAFIRE. METHODS: Liver volumes were segmented from 23 abdominal CT cases. The volumes were characterized in terms of texture features from gray-level co-occurrence and run-length matrices...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27891546/ct-image-quality-in-sinogram-affirmed-iterative-reconstruction-phantom-study-is-there-a-point-of-diminishing-returns
#10
Juan C Infante, Yu Liu, Cynthia K Rigsby
BACKGROUND: In our pediatric practice, we have observed qualitatively limited improvement in the image quality of images generated with sinogram affirmed iterative reconstruction (SAFIRE) compared to series generated with filtered back projection (FBP), particularly in cases near or below a CT dose index volume (CTDIvol) of 1-mGy. OBJECTIVE: To determine whether the image quality advantage of SAFIRE remains constant across clinically used CT dose levels in an American College of Radiology (ACR) CT accreditation phantom including the lower dose range used in pediatric imaging...
November 28, 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27804233/quality-of-life-development-during-initial-hemodialysis-therapy-and-association-with-loss-of-residual-renal-function
#11
Christina G Poulsen, Krista D Kjaergaard, Christian D Peters, Bente Jespersen, Jens D Jensen
Introduction Health related quality of life (HRQOL) is markedly reduced in hemodialysis patients compared to the general population. We investigated the course of self-reported HRQOL over time and the association with selected factors, focusing on changes in glomerular filtration rate (GFR). Methods Eighty-two newly started hemodialysis patients from the SAFIR cohort filled out the Kidney Disease Quality of Life Short Form Version 1.3 (KDQOL-SF(TM) ) questionnaire at baseline, 6 and 12 months. The SAFIR study was a randomized, placebo-controlled, double-blind intervention study, examining the effects of the angiotensin II receptor blocker irbesartan...
November 1, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27791237/preoperative-planning-of-total-hip-arthroplasty-on-dysplastic-acetabuli
#12
Dror Lakstein, Zachary Tan, Nugzar Oren, Tatu Johannes Mäkinen, Allan E Gross, Oleg Safir
BACKGROUND: When performing total hip arthroplasty (THA) on a dysplastic hip, proper positioning of the acetabular component may not allow for more than 70% coverage. Structural support in the form of an autograft or a high porosity metal augment may be necessary. The purpose of the study was to investigate the value of preoperative templating and deformity classification in predicting cup coverage and the need for structural support. METHODS: 65 cases of THA for DDH were retrospectively analysed...
October 24, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/27717652/synthesis-and-evaluation-of-the-structural-elements-in-alkylated-tetrahydroisoquinolines-for-binding-to-cns-receptors
#13
Edward Ofori, Xue Y Zhu, Jagan R Etukala, Barbara A Bricker, Seth Y Ablordeppey
Diseases of the CNS are often complex and involve multiple receptor systems and thus, the treatment options for these diseases must focus on targeting the multiple receptors implicated in the various disorders. Schizophrenia and depression are examples of such diseases and their pharmacotherapy thus depends on agents which target multiple receptors including the dopamine, serotonin and even cholinergic receptors at the same time. In our previous campaign to find multi-receptor ligands, we have identified the benzothiazole 1a as an initial lead molecule...
November 15, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27662618/indirect-ct-venography-at-80-kvp-with-sinogram-affirmed-iterative-reconstruction-compared-to-120-kvp-with-filtered-back-projection-assessment-of-image-quality-and-radiation-dose
#14
Inyoung Song, Jeong Geun Yi, Jeong Hee Park, Sung Min Ko
OBJECTIVE: To evaluate the image quality and radiation dose of indirect computed tomographic venography (CTV) using 80 kVp with sinogram-affirmed iterative reconstruction (SAFIRE) and 120 kVp with filtered back projection (FBP). MATERIALS AND METHODS: This retrospective study was approved by our institution and informed consent was waived. Sixty-one consecutive patients (M: F = 27: 34, mean age 60 ± 16, mean BMI 23.6 ± 3.6 kg/m2) underwent pelvic and lower extremity CTVs [group A (n = 31, 120 kVp, reconstructed with FBP) vs...
2016: PloS One
https://www.readbyqxmd.com/read/27648999/effect-of-iterative-reconstruction-on-image-quality-of-low-dose-chest-computed-tomography
#15
Antonio Pavarani, Chiara Martini, Veronica Gafa', Paola Bini, Mario Silva, Caterina Ghetti, Nicola Sverzellati
AIM: To assess quality and radiologists' preference of low-dose computed tomography (LDCT) reconstructed with filtered back projection (FBP) or Iterative Reconstruction. METHODS: Thin-section LDCTs (1-mm thick contiguous images; 120 kVp; 30 mAs) of 38 consecutive unselected patients, evaluated for various clinical indications, were reconstructed by four different reconstruction algorithms: FBP and Sinogram-AFfirmed Iterative Reconstruction (SAFIRE) with three different strengths, from 2 to 4 (i...
September 13, 2016: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/27612054/objective-performance-assessment-of-five-computed-tomography-iterative-reconstruction-algorithms
#16
Azeez Omotayo, Idris Elbakri
OBJECTIVE: Iterative algorithms are gaining clinical acceptance in CT. We performed objective phantom-based image quality evaluation of five commercial iterative reconstruction algorithms available on four different multi-detector CT (MDCT) scanners at different dose levels as well as the conventional filtered back-projection (FBP) reconstruction. METHODS: Using the Catphan500 phantom, we evaluated image noise, contrast-to-noise ratio (CNR), modulation transfer function (MTF) and noise-power spectrum (NPS)...
November 22, 2016: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/27555358/author-reply
#17
Ilan J Safir, Christopher P Filson
No abstract text is available yet for this article.
November 2016: Urology
https://www.readbyqxmd.com/read/27551339/value-of-liver-computed-tomography-with-iodixanol-270-80-kvp-and-iterative-reconstruction
#18
Diomidis Botsikas, Isabelle Barnaure, Sylvain Terraz, Christoph D Becker, Anastasia Kalovidouri, Xavier Montet
AIM: To evaluate the image quality of hepatic multidetector computed tomography (MDCT) with dynamic contrast enhancement. METHODS: It uses iodixanol 270 mg/mL (Visipaque 270) and 80 kVp acquisitions reconstructed with sinogram affirmed iterative reconstruction (SAFIRE(®)) in comparison with a standard MDCT protocol. Fifty-three consecutive patients with known or suspected hepatocellular carcinoma underwent 55 CT examinations, with two different four-phase CT protocols...
July 28, 2016: World Journal of Radiology
https://www.readbyqxmd.com/read/27548343/noise-texture-deviation-a-measure-for-quantifying-artifacts-in-computed-tomography-images-with-iterative-reconstructions
#19
Fabian Morsbach, Lotus Desbiolles, Rainer Raupach, Sebastian Leschka, Bernhard Schmidt, Hatem Alkadhi
OBJECTIVES: The aims of this study were to introduce the measure noise texture deviation as quantitative parameter for evaluating iterative reconstruction (IR)-specific artifacts in computed tomography (CT) images and to test whether IR-specific artifacts, quantified through this measure, are reduced in advanced modeled IR (ADMIRE) as compared with sinogram-affirmed IR (SAFIRE) images of the liver ex vivo and in patients with hypodense liver lesions. MATERIALS AND METHODS: In the ex vivo study part, an abdominal phantom was used...
February 2017: Investigative Radiology
https://www.readbyqxmd.com/read/27545872/three-dimensional-cell-culture-model-utilization-in-cancer-stem-cell-research
#20
Zofia F Bielecka, Kamila Maliszewska-Olejniczak, Ilan J Safir, Cezary Szczylik, Anna M Czarnecka
Three-dimensional (3D) cell culture models are becoming increasingly popular in contemporary cancer research and drug resistance studies. Recently, scientists have begun incorporating cancer stem cells (CSCs) into 3D models and modifying culture components in order to mimic in vivo conditions better. Currently, the global cell culture market is primarily focused on either 3D cancer cell cultures or stem cell cultures, with less focus on CSCs. This is evident in the low product availability officially indicated for 3D CSC model research...
August 22, 2016: Biological Reviews of the Cambridge Philosophical Society
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