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Edward Ofori, Xue Y Zhu, Jagan R Etukala, Barbara A Bricker, Seth Y Ablordeppey
Diseases of the CNS are often complex and involve multiple receptor systems and thus, the treatment options for these diseases must focus on targeting the multiple receptors implicated in the various disorders. Schizophrenia and depression are examples of such diseases and their pharmacotherapy thus depends on agents which target multiple receptors including the dopamine, serotonin and even cholinergic receptors at the same time. In our previous campaign to find multi-receptor ligands, we have identified the benzothiazole 1a as an initial lead molecule...
September 10, 2016: Bioorganic & Medicinal Chemistry
Inyoung Song, Jeong Geun Yi, Jeong Hee Park, Sung Min Ko
OBJECTIVE: To evaluate the image quality and radiation dose of indirect computed tomographic venography (CTV) using 80 kVp with sinogram-affirmed iterative reconstruction (SAFIRE) and 120 kVp with filtered back projection (FBP). MATERIALS AND METHODS: This retrospective study was approved by our institution and informed consent was waived. Sixty-one consecutive patients (M: F = 27: 34, mean age 60 ± 16, mean BMI 23.6 ± 3.6 kg/m2) underwent pelvic and lower extremity CTVs [group A (n = 31, 120 kVp, reconstructed with FBP) vs...
2016: PloS One
Antonio Pavarani, Chiara Martini, Veronica Gafa', Paola Bini, Mario Silva, Caterina Ghetti, Nicola Sverzellati
AIM: To assess quality and radiologists' preference of low-dose computed tomography (LDCT) reconstructed with filtered back projection (FBP) or Iterative Reconstruction. METHODS: Thin-section LDCTs (1-mm thick contiguous images; 120 kVp; 30 mAs) of 38 consecutive unselected patients, evaluated for various clinical indications, were reconstructed by four different reconstruction algorithms: FBP and Sinogram-AFfirmed Iterative Reconstruction (SAFIRE) with three different strengths, from 2 to 4 (i...
September 13, 2016: Acta Bio-medica: Atenei Parmensis
Azeez Omotayo, Idris Elbakri
OBJECTIVE: Iterative algorithms are gaining clinical acceptance in CT. We performed objective phantom-based image quality evaluation of five commercial iterative reconstruction algorithms available on four different multi-detector CT (MDCT) scanners at different dose levels as well as the conventional filtered back-projection (FBP) reconstruction. METHODS: Using the Catphan500 phantom, we evaluated image noise, contrast-to-noise ratio (CNR), modulation transfer function (MTF) and noise-power spectrum (NPS)...
September 9, 2016: Journal of X-ray Science and Technology
Ilan J Safir, Christopher P Filson
No abstract text is available yet for this article.
August 20, 2016: Urology
Diomidis Botsikas, Isabelle Barnaure, Sylvain Terraz, Christoph D Becker, Anastasia Kalovidouri, Xavier Montet
AIM: To evaluate the image quality of hepatic multidetector computed tomography (MDCT) with dynamic contrast enhancement. METHODS: It uses iodixanol 270 mg/mL (Visipaque 270) and 80 kVp acquisitions reconstructed with sinogram affirmed iterative reconstruction (SAFIRE(®)) in comparison with a standard MDCT protocol. Fifty-three consecutive patients with known or suspected hepatocellular carcinoma underwent 55 CT examinations, with two different four-phase CT protocols...
July 28, 2016: World Journal of Radiology
Fabian Morsbach, Lotus Desbiolles, Rainer Raupach, Sebastian Leschka, Bernhard Schmidt, Hatem Alkadhi
OBJECTIVES: The aims of this study were to introduce the measure noise texture deviation as quantitative parameter for evaluating iterative reconstruction (IR)-specific artifacts in computed tomography (CT) images and to test whether IR-specific artifacts, quantified through this measure, are reduced in advanced modeled IR (ADMIRE) as compared with sinogram-affirmed IR (SAFIRE) images of the liver ex vivo and in patients with hypodense liver lesions. MATERIALS AND METHODS: In the ex vivo study part, an abdominal phantom was used...
August 19, 2016: Investigative Radiology
Zofia F Bielecka, Kamila Maliszewska-Olejniczak, Ilan J Safir, Cezary Szczylik, Anna M Czarnecka
Three-dimensional (3D) cell culture models are becoming increasingly popular in contemporary cancer research and drug resistance studies. Recently, scientists have begun incorporating cancer stem cells (CSCs) into 3D models and modifying culture components in order to mimic in vivo conditions better. Currently, the global cell culture market is primarily focused on either 3D cancer cell cultures or stem cell cultures, with less focus on CSCs. This is evident in the low product availability officially indicated for 3D CSC model research...
August 22, 2016: Biological Reviews of the Cambridge Philosophical Society
Andrea I Schmid, Michael Uder, Michael M Lell
OBJECTIVES: Aim of this study was to evaluate image quality and radiation dose in low dose head neck computed tomography (CT) comparing two different commercially available iterative reconstruction algorithms SAFIRE and ADMIRE with fixed and automated tube voltage adaptation (TVA). METHODS: CT examinations of 103 patients were analysed. 58 patients were examined on a single-source CT at fixed tube voltage of 120 kV and reconstructed with FBP and sinogram affirmed iterative reconstruction (SAFIRE, strength level 3)...
August 19, 2016: Dento Maxillo Facial Radiology
Francesco Macri, Joel Greffier, Fabricio Pereira, Alina Chica Rosa, Elina Khasanova, Pierre-Geraut Claret, Ahmed Larbi, Gianfranco Gualdi, Jean Paul Beregi
OBJECTIVE: To compare the diagnostic confidence between low-dose computed-tomography (LDCT) and ultra-low-dose CT (ULDCT) of the chest on a single source CT system (SSCT) for patients with acute dyspnoea. MATERIALS AND METHODS: One hundred thirty-three consecutive dyspnoeic patients referred from the emergency room (ER) were selected to undergo two sequential non-enhanced chest CT acquisitions: LDCT first acquisition (100kVp and 60mAs), followed by ULDCT (100kVp±20 and 10mAs)...
September 2016: European Journal of Radiology
Stephan Ellmann, Ferdinand Kammerer, Thomas Allmendinger, Michael Brand, Rolf Janka, Matthias Hammon, Michael M Lell, Michael Uder, Manuel Kramer
OBJECTIVES: This study aimed to determine the degree of radiation dose reduction in neck computed tomography angiography (CTA) achievable with Sinogram-affirmed iterative reconstruction (SAFIRE) algorithms. METHODS: Ten consecutive patients scheduled for neck CTA were included in this study. CTA images of the external carotid arteries were reconstructed with either filtered back projection at full radiation dose level or underwent simulated dose-reduction by a proprietary reconstruction software...
July 27, 2016: Dento Maxillo Facial Radiology
F Macri, J Greffier, F R Pereira, C Mandoul, E Khasanova, G Gualdi, J P Beregi
PURPOSE: To evaluate the effect of dose reduction with iterative reconstruction (IR) on image quality of chest CT scan. MATERIALS AND METHODS: Eighteen human cadavers had chest CT with one reference CT protocol (RP-CT; 120kVp/200mAs) and two protocols with dose reduction: low-dose-CT (LD-CT; 120kVp/40mAs) and ultra-low-dose CT (ULD-CT; 120kVp/10mAs). Data were reconstructed with filter-back-projection (FBP) for RP-CT and with FBP and IR (sinogram affirmed iterative reconstruction [SAFIRE(®)]) algorithm for LD-CT and ULD-CT...
July 20, 2016: Diagnostic and Interventional Imaging
Ilan J Safir, Salil Gabale, Samuel A David, Jonathan H Huang, Robert S Gerhard, Jeffrey Pearl, Charles A Lorentz, James Baumgardner, Christopher P Filson, Muta M Issa
OBJECTIVES: To report on results from a new tele-urology pathway for managing hematuria consults, including a survey of patient attitudes and satisfaction with such a program. Recent guideline changes have relaxed the definition of microscopic hematuria and may have significantly increased the number of hematuria evaluations. METHODS: Patients referred to the Atlanta Veterans Administration Medical Center with hematuria were scheduled for a tele-urology clinic encounter utilizing a telephone call to obtain hematuria-related clinical information via a standardized algorithm...
July 19, 2016: Urology
Wael A Rahman, Tomás Amenábar, Bandar M Hetaimish, Oleg A Safir, Paul R Kuzyk, Allan E Gross
BACKGROUND: This is a retrospective review of the functional outcomes and complications of revision total hip arthroplasty (THA) of failed metal-on-metal (MoM) hip arthroplasty. METHODS: A total of 20 revision THAs were performed in 19 patients. Of them, 2 cases were failed hip resurfacing, and 18 cases were failed (MoM) THA. The mean age at revision (THA) was 59.35 years (standard deviation [SD] 9.83). RESULTS: The mean follow-up was 45 months (SD 13...
May 6, 2016: Journal of Arthroplasty
Christian D Peters, Krista D Kjaergaard, Claus H Nielsen, Kent L Christensen, Bo M Bibby, Jens D Jensen, Bente Jespersen
Introduction Low-grade chronic inflammation is common in hemodialysis (HD) patients. Previous studies suggest an anti-inflammatory effect of angiotensin II receptor blocker (ARB) treatment. The aim of this study was to compare the effect of ARB vs. placebo on plasma concentrations of inflammatory markers in HD patients. Methods Adult HD patients were randomized for double-blind treatment with the ARB irbesartan 150-300 mg/day or placebo. At baseline, 1 week, 3, 6, 9, and 12 months plasma high sensitivity C-reactive protein (hsCRP), interleukin (IL)-1β, IL-6, IL-8, IL-18, and transforming growth factor-β (TGF-β) were measured using Luminex and enzyme-linked immunosorbent assay (ELISA) technology...
June 27, 2016: Hemodialysis International
Olivier Soenen, Christophe Balliauw, Raymond Oyen, Federica Zanca
The aim of this study was to compare dose and image quality (IQ) of a baseline low-dose computed tomography (CT) (fix mAs) vs. an ultra-low-dose CT (automatic tube current modulation, ATCM) in patients with suspected urinary stone disease and to assess the added value of iterative reconstruction. CT examination was performed on 193 patients (103 baseline low-dose, 90 ultra-low-dose). Filtered back projection (FBP) was used for both protocols, and Sinogram Affirmed Iterative Reconstruction (SAFIRE) was used for the ultra-low-dose protocol only...
May 31, 2016: Radiation Protection Dosimetry
Michael Drexler, Paul R T Kuzyk, Kevin Koo, Allan E Gross, Yona Kosashvili, Nickola Reischl, Tal Frenkel Rutenberg, Oleg Safir
BACKGROUND: Antibiotic-loaded cement spacers in first-stage revision total hip arthroplasty (THA) for managing infection are associated with high dislocation and fracture rates. The aim of this study was to report the use of an antibiotic-loaded cemented supra-acetabular roof augmentation to reinforce hip stability after cement spacer insertion for first-stage total hip revision in the treatment of infected THA. METHODS: We retrospectively reviewed a consecutive series of 50 THAs involving 47 patients with an infected hip requiring staged revisions of THA...
April 30, 2016: Journal of Arthroplasty
Namita S Gandhi, Mark E Baker, Ajit H Goenka, Jennifer A Bullen, Nancy A Obuchowski, Erick M Remer, Christopher P Coppa, David Einstein, Myra K Feldman, Devaraju Kanmaniraja, Andrei S Purysko, Noushin Vahdat, Andrew N Primak, Wadih Karim, Brian R Herts
Purpose To compare the diagnostic accuracy and image quality of computed tomographic (CT) enterographic images obtained at half dose and reconstructed with filtered back projection (FBP) and sinogram-affirmed iterative reconstruction (SAFIRE) with those of full-dose CT enterographic images reconstructed with FBP for active inflammatory terminal or neoterminal ileal Crohn disease. Materials and Methods This retrospective study was compliant with HIPAA and approved by the institutional review board. The requirement to obtain informed consent was waived...
August 2016: Radiology
Robert Becker, Chiara Casella, Gunther Dissertori, Jannis Fischer, Alexander Howard, Astrik Jeitler, Werner Lustermann, Ulf Roeser, Qiulin Wang, Bruno Weber
No abstract text is available yet for this article.
December 2015: EJNMMI Physics
Tatu J Mäkinen, Paul Kuzyk, Oleg A Safir, David Backstein, Allan E Gross
➤ The outcome of acetabular revision is heavily influenced by the degree of associated bone loss.➤ Uncemented hemispherical acetabular components can be used in the majority of acetabular revisions, although occasionally the degree of bone loss precludes the stability of the hemispherical component at the correct anatomic level or there is minimal bleeding host bone left for biologic fixation.➤ Massive acetabular bone loss resulting in the need for bone grafts or highly porous augments involving more than half of the acetabulum is one of the main indications for the use of cages...
February 3, 2016: Journal of Bone and Joint Surgery. American Volume
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