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https://www.readbyqxmd.com/read/28713667/absent-congenital-cervical-pedicle-nearly-misdiagnosed-as-a-facet-dislocation-a-case-report
#1
Scott Safir, Jonathan Rasouli, Jeremy Steinberger, Branko Skovrlj, Amish Doshi, Konstantinos Margetis, Saadi Ghatan
BACKGROUND: Cervical spinal injury encompasses up to 1.5% of all pediatric injuries. Children, and more specifically infants, are a difficult subset of patients to obtain neurological exam in the setting of trauma, thus necessitating the use of cervical X-rays, CT scans, and MRI imaging. CASE DESCRIPTION: A healthy, 15-month-old boy had an unwitnessed fall down a flight of stairs and received a CT scan of the head and cervical spine in the emergency department due to cephalohematoma and mechanism of injury...
September 2017: Interdisciplinary Neurosurgery: Advanced Techniques and Case Management
https://www.readbyqxmd.com/read/28693049/hybrid-repair-techniques-for-complex-aneurysms-and-dissections-involving-the-aortic-arch-and-thoracic-aorta
#2
Rami Tadros, Scott R Safir, Peter L Faries, Daniel K Han, Rajiv K Chander, James F McKinsey, Michael L Marin, Allan S Stewart, Sharif Ellozy
Aortic aneurysms involving the ascending aorta, aortic arch, and descending thoracic aorta have been a challenging entity to surgically treat for over 60 years. Despite the mortality of the disease, early open surgical procedures also had significant morbidity and mortality. The inherent risk in treating multiple anatomic segments simultaneously led to the innovation of the staged elephant trunk (ET) approach by Borst in 1983. To avoid the thoracotomy and associated complications related to the second stage of the procedure, an endovascular completion paradigm was begun by Volodos in 1991...
July 11, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28693048/the-use-of-branched-endografts-for-the-aortic-arch-in-the-endovascular-era
#3
Rami O Tadros, Scott R Safir, Peter L Faries, Daniel K Han, Rajiv K Chander, Cherrie Z Abraham, Michael L Marin, Allan S Stewart
The endovascular realm has steadily increased its footing in the treatment of the aorta and all of its territories since the foundational case in 1990 by Parodi. The aortic arch, however, continues to be one of the last bastions for treatment via open surgery, which remains the gold standard. Significant comorbidity and prior cardiac surgery prevent open surgery from being the only preferred option, allowing novel endovascular procedures to be considered. Since 1999, more advanced endovascular systems have been created by companies such as Cook Medical, Bolton Medical, Medtronic, Endospan, Gore Medical, and, recently, Kawasumi...
July 11, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28678818/image-quality-diagnostic-accuracy-and-potential-for-radiation-dose-reduction-in-thoracoabdominal-ct-using-sinogram-affirmed-iterative-reconstruction-safire-technique-in-a-longitudinal-study
#4
Michael Scharf, Stephanie Brendel, Katja Melzer, Christian Hentschke, Matthias May, Michael Uder, Michael M Lell
OBJECTIVE: To step-wise evaluate image quality of sinogram-affirmed iterative reconstruction (SAFIRE) in reduced-dose (RD) thoracoabdominal computed tomography (CT) compared to full-dose (FD) and RD filtered back projection (FBP) in a longitudinal study. MATERIALS AND METHODS: 122 patients were included in this prospective study. 49 patients (14 men: mean age ± SD, 56±0.4 years; 35 women: 58±1.3 years) completed FD, RD1 (80%-dose) and RD2 (60%-dose) thoracoabdominal CT...
2017: PloS One
https://www.readbyqxmd.com/read/28608697/perspectives-of-cannabinoid-type-2-receptor-cb2r-ligands-in-neurodegenerative-disorders-structure-affinity-relationship-safir-and-structure-activity-relationship-sar-studies
#5
Francesco Spinelli, Elena Capparelli, Carmen Abate, Nicola A Colabufo, Marialessandra Contino
Up-regulation of CB2R on activated microglial cells, the first step in neurodegeneration, has been widely demonstrated, and this finding makes the receptor a promising target in the early diagnosis and treatment of several neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and multiple sclerosis (MS). The development of CB2R PET ligands could help demonstrate the neurodegenerative pathogenesis, thus providing useful tools for characterizing the role of neuroinflammation in the progression of these disorders...
June 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28455469/management-of-massive-acetabular-bone-defects-in-revision-arthroplasty-of-the-hip-using-a-reconstruction-cage-and-porous-metal-augment
#6
T J Mäkinen, M Abolghasemian, E Watts, S G Fichman, P Kuzyk, O A Safir, A E Gross
AIMS: It may not be possible to undertake revision total hip arthroplasty (THA) in the presence of massive loss of acetabular bone stock using standard cementless hemispherical acetabular components and metal augments, as satisfactory stability cannot always be achieved. We aimed to study the outcome using a reconstruction cage and a porous metal augment in these patients. PATIENTS AND METHODS: A total of 22 acetabular revisions in 19 patients were performed using a combination of a reconstruction cage and porous metal augments...
May 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28296730/image-quality-evaluation-for-care-kv-technique-combined-with-iterative-reconstruction-for-chest-computed-tomography-scanning
#7
RANDOMIZED CONTROLLED TRIAL
Bin Yang, Zheng-Liang Li, Yi Gao, Ya-Ying Yang, Wei Zhao
BACKGROUND: To investigate the radiation dose and image quality for iterative reconstruction combined with the CARE kV technique in chest computed tomography (CT) scanning for physical examination. METHODS: A total of 130 patients who underwent chest CT scanning were randomly chosen and the quality reference value was set as 80 mAs. The scanning scheme was set and the patients were randomly divided into groups according to the scanning scheme. Sixty patients underwent a chest scan with 100 kV using the CARE kV technique and SAFIRE reconstruction (value=3) (experimental group) and the other 70 patients underwent chest scanning with 120 kV (control group)...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28274634/assessment-of-new-triplet-forming-artificial-nucleobases-as-rna-ligands-directed-towards-hcv-ires-iiid-loop
#8
Mauro Safir Filho, Anthony R Martin, Rachid Benhida
We report the synthesis of two new artificial nucleobase scaffolds, 1 and 2, featuring adequate hydrogen bonding donors and acceptors for the molecular recognition of U:A and C:G base pairs, respectively. The tethering of these structures to various amino acids and the assessment of these artificial nucleobase-amino acid conjugates as RNA ligands against a model of HCV IRES IIId domain are also reported. Compound 1e displayed the highest affinity (Kd twice lower than neomycin - control). Moreover, it appears that this interaction is enthalpically and entropically favored...
April 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28170300/effect-of-radiation-dose-reduction-and-reconstruction-algorithm-on-image-noise-contrast-resolution-and-detectability-of-subtle-hypoattenuating-liver-lesions-at-multidetector-ct-filtered-back-projection-versus-a-commercial-model-based-iterative-reconstruction
#9
Justin Solomon, Daniele Marin, Kingshuk Roy Choudhury, Bhavik Patel, Ehsan Samei
Purpose To determine the effect of radiation dose and iterative reconstruction (IR) on noise, contrast, resolution, and observer-based detectability of subtle hypoattenuating liver lesions and to estimate the dose reduction potential of the IR algorithm in question. Materials and Methods This prospective, single-center, HIPAA-compliant study was approved by the institutional review board. A dual-source computed tomography (CT) system was used to reconstruct CT projection data from 21 patients into six radiation dose levels (12...
February 7, 2017: Radiology
https://www.readbyqxmd.com/read/28125231/improved-fluorescent-protein-contrast-and-discrimination-by-optically-controlling-dark-state-lifetimes
#10
Yen-Cheng Chen, Robert M Dickson
Modulation and optical control of photoswitchable fluorescent protein (PS-FP) dark state lifetimes drastically improves sensitivity and selectivity in fluorescence imaging. The dark state population of PS-FPs generates an out-of-phase fluorescence component relative to the sinusoidally modulated 488 nm laser excitation. Because this apparent phase advanced emission results from slow recovery to the fluorescent manifold, we hasten recovery and, therefore, modulation frequency by varying coillumination intensity at 405 nm...
February 16, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28050639/cerebral-bone-subtraction-ct-angiography-using-80%C3%A2-kvp-and-sinogram-affirmed-iterative-reconstruction-contrast-medium-and-radiation-dose-reduction-with-improvement-of-image-quality
#11
Yasunori Nagayama, Takeshi Nakaura, Akinori Tsuji, Joji Urata, Mitsuhiro Furusawa, Hideaki Yuki, Kenichiro Hirarta, Seitaro Oda, Masafumi Kidoh, Daisuke Utsunomiya, Yasuyuki Yamashita
INTRODUCTION: The purpose of this study was to evaluate the feasibility of a contrast medium (CM), radiation dose reduction protocol for cerebral bone-subtraction CT angiography (BSCTA) using 80-kVp and sinogram-affirmed iterative reconstruction (SAFIRE). METHODS: Seventy-five patients who had undergone BSCTA under the 120- (n = 37) or the 80-kVp protocol (n = 38) were included. CM was 370 mgI/kg for the 120-kVp and 296 mgI/kg for the 80-kVp protocol; the 120- and the 80-kVp images were reconstructed with filtered back-projection (FBP) and SAFIRE, respectively...
January 3, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28048150/th-cd-207b-04-is-ttf-a-true-representation-of-the-sharpness-property-of-a-non-linear-ct-system
#12
M Robins, J Solomon, E Samei
PURPOSE: To investigate if the task-transfer-function (TTF) accurately models the transfer properties of a CT system for lung nodule imaging. METHODS: An anthropomorphic lung phantom was imaged using a standard chest protocol on a clinical CT scanner with and without 24 physically inserted synthetic lesions (nominal diameter: 8 - 10 mm). Images were reconstructed using FBP and iterative algorithm (SAFIRE, Siemens Healthcare). 3D TTF was measured using an established technique...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048039/su-f-i-74-dose-evaluation-based-on-monte-carlo-simulation-of-three-dimensional-rotational-angiography-during-hepatic-transarterial-chemoembolization-procedures
#13
Y Hwang, K Lui, Y Lin, H Tsai
PURPOSE: This study was aimed to investigate the dose with patient performing three-dimensional (3D) angiography imaging during hepatic transarterial chemoembolization (TACE) procedures. METHODS: Organ doses and effective doses calculations were retrospectively performed in 88 patients (61 males and 27 females with averaged age of 65.4±12.6 years old) referred for hepatic TACE on a digital flat-panel angiography system (Bransist safire; Shimadzu) using software (PCXMC; Helsinki, Finland) based on Monte Carlo technique...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047530/su-f-p-45-clinical-experience-with-radiation-dose-reduction-of-ct-examinations-using-iterative-reconstruction-algorithms
#14
V Weir, J Zhang
PURPOSE: Iterative reconstruction (IR) algorithms have been adopted by medical centers in the past several years. IR has a potential to substantially reduce patient dose while maintaining or improving image quality. This study characterizes dose reductions in clinical settings for CT examinations using IR. METHODS: We retrospectively analyzed dose information from patients who underwent abdomen/pelvis CT examinations with and without contrast media in multiple locations of our Healthcare system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27935766/dual-source-single-energy-multidetector-ct-used-to-obtain-multiple-radiation-exposure-levels-within-the-same-patient-phantom-development-and-clinical-validation
#15
Davide Bellini, Juan Carlos Ramirez-Giraldo, Alex Bibbey, Justin Solomon, Lynne M Hurwitz, Alfredo Farjat, Achille Mileto, Ehsan Samei, Daniele Marin
Purpose To develop, in a phantom environment, a method to obtain multidetector computed tomographic (CT) data sets at multiple radiation exposure levels within the same patient and to validate its use for potential dose reduction by using different image reconstruction algorithms for the detection of liver metastases. Materials and Methods The American College of Radiology CT accreditation phantom was scanned by using a dual-source multidetector CT platform. By adjusting the radiation output of each tube, data sets at six radiation exposure levels (100%, 75%, 50%, 37...
May 2017: Radiology
https://www.readbyqxmd.com/read/27924781/development-of-sns2-rgo-nanosheet-composite-for-cost-effective-aqueous-hybrid-supercapacitors
#16
Himani Chauhan, Manoj K Singh, Praveen Kumar, Safir Ahmad Hashmi, Sasanka Deka
The development of low cost supercapacitor cells with unique capacitive properties is essential for many domestic and industrial purposes. Here we report the first ever application of SnS2-reduced graphene oxide (SnS2/RGO) layered nanocomposite as a superior electrode material for symmetric aqueous hybrid supercapacitors. We synthesized SnS2/RGO nanocomposite comprised of nanosheets of SnS2 and graphene oxide via a one-pot hydrothermal approach. in situ as-synthesized SnS2/RGO is devised for the first time to give high specific capacitance 500 Fg(-1), energy density 16...
January 13, 2017: Nanotechnology
https://www.readbyqxmd.com/read/27908164/comparison-of-low-contrast-detectability-between-two-ct-reconstruction-algorithms-using-voxel-based-3d-printed-textured-phantoms
#17
COMPARATIVE STUDY
Justin Solomon, Alexandre Ba, François Bochud, Ehsan Samei
PURPOSE: To use novel voxel-based 3D printed textured phantoms in order to compare low-contrast detectability between two reconstruction algorithms, FBP (filtered-backprojection) and SAFIRE (sinogram affirmed iterative reconstruction) and determine what impact background texture (i.e., anatomical noise) has on estimating the dose reduction potential of SAFIRE. METHODS: Liver volumes were segmented from 23 abdominal CT cases. The volumes were characterized in terms of texture features from gray-level co-occurrence and run-length matrices...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27891546/ct-image-quality-in-sinogram-affirmed-iterative-reconstruction-phantom-study-is-there-a-point-of-diminishing-returns
#18
Juan C Infante, Yu Liu, Cynthia K Rigsby
BACKGROUND: In our pediatric practice, we have observed qualitatively limited improvement in the image quality of images generated with sinogram affirmed iterative reconstruction (SAFIRE) compared to series generated with filtered back projection (FBP), particularly in cases near or below a CT dose index volume (CTDIvol) of 1-mGy. OBJECTIVE: To determine whether the image quality advantage of SAFIRE remains constant across clinically used CT dose levels in an American College of Radiology (ACR) CT accreditation phantom including the lower dose range used in pediatric imaging...
November 28, 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27804233/quality-of-life-development-during-initial-hemodialysis-therapy-and-association-with-loss-of-residual-renal-function
#19
Christina G Poulsen, Krista D Kjaergaard, Christian D Peters, Bente Jespersen, Jens D Jensen
INTRODUCTION: Health related quality of life (HRQOL) is markedly reduced in hemodialysis patients compared to the general population. We investigated the course of self-reported HRQOL over time and the association with selected factors, focusing on changes in glomerular filtration rate (GFR). METHODS: Eighty-two newly started hemodialysis patients from the SAFIR cohort filled out the Kidney Disease Quality of Life Short Form Version 1.3 (KDQOL-SF(TM) ) questionnaire at baseline, 6 and 12 months...
July 2017: Hemodialysis International
https://www.readbyqxmd.com/read/27791237/preoperative-planning-of-total-hip-arthroplasty-on-dysplastic-acetabuli
#20
Dror Lakstein, Zachary Tan, Nugzar Oren, Tatu Johannes Mäkinen, Allan E Gross, Oleg Safir
BACKGROUND: When performing total hip arthroplasty (THA) on a dysplastic hip, proper positioning of the acetabular component may not allow for more than 70% coverage. Structural support in the form of an autograft or a high porosity metal augment may be necessary. The purpose of the study was to investigate the value of preoperative templating and deformity classification in predicting cup coverage and the need for structural support. METHODS: 65 cases of THA for DDH were retrospectively analysed...
October 24, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
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